ADCY10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)5.58596370
2diol metabolic process (GO:0034311)5.06961083
3sphingoid metabolic process (GO:0046519)4.99656719
4DNA methylation involved in gamete generation (GO:0043046)4.80307336
5positive regulation of gamma-delta T cell activation (GO:0046645)4.24174640
6negative regulation of cell killing (GO:0031342)4.17090599
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17090599
8piRNA metabolic process (GO:0034587)4.15017839
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14449433
10regulation of B cell receptor signaling pathway (GO:0050855)4.12288548
11regulation of meiosis I (GO:0060631)3.98028019
12establishment of protein localization to Golgi (GO:0072600)3.84495227
13negative regulation of glycoprotein biosynthetic process (GO:0010561)3.83552199
14regulation of gamma-delta T cell activation (GO:0046643)3.61766863
15negative regulation of T cell mediated immunity (GO:0002710)3.60696381
16protein targeting to Golgi (GO:0000042)3.51000201
17centriole replication (GO:0007099)3.48796987
18regulation of gamma-delta T cell differentiation (GO:0045586)3.45546197
19negative regulation of cAMP-mediated signaling (GO:0043951)3.40809243
20protein-chromophore linkage (GO:0018298)3.36733819
21adaptation of signaling pathway (GO:0023058)3.32651795
22germinal center formation (GO:0002467)3.31941135
23neural tube formation (GO:0001841)3.27210470
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.23029349
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.21519338
26protein K11-linked deubiquitination (GO:0035871)3.17311955
27neutrophil activation involved in immune response (GO:0002283)3.14976177
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14942853
29sperm motility (GO:0030317)3.13726518
30tachykinin receptor signaling pathway (GO:0007217)3.13017380
31regulation of protein glycosylation (GO:0060049)3.08117254
32phosphatidylethanolamine metabolic process (GO:0046337)3.07196743
33positive regulation of developmental pigmentation (GO:0048087)3.04164046
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.99422395
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98827703
36B cell receptor signaling pathway (GO:0050853)2.98666952
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96723550
38negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91862512
39gamma-aminobutyric acid signaling pathway (GO:0007214)2.89014181
40response to interleukin-15 (GO:0070672)2.88558908
41mast cell degranulation (GO:0043303)2.88075800
42mast cell activation involved in immune response (GO:0002279)2.88075800
43cilium or flagellum-dependent cell motility (GO:0001539)2.87534080
44centriole assembly (GO:0098534)2.87443505
45regulation of pigment cell differentiation (GO:0050932)2.86593506
46cellular response to interleukin-15 (GO:0071350)2.84560241
47cellular response to ethanol (GO:0071361)2.81163342
48positive regulation of granulocyte differentiation (GO:0030854)2.76631767
49negative regulation of mast cell activation (GO:0033004)2.76487903
50neutrophil activation (GO:0042119)2.75993935
51phosphatidylethanolamine biosynthetic process (GO:0006646)2.74946795
52regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.74090333
53activated T cell proliferation (GO:0050798)2.72325949
54acrosome reaction (GO:0007340)2.72031822
55microglial cell activation (GO:0001774)2.71072876
56macrophage activation involved in immune response (GO:0002281)2.69804314
57regulation of mast cell activation (GO:0033003)2.69229482
58mast cell activation (GO:0045576)2.69091536
59negative regulation of inclusion body assembly (GO:0090084)2.67874719
60tyrosine phosphorylation of STAT protein (GO:0007260)2.67593357
61multicellular organism reproduction (GO:0032504)2.67002692
62L-fucose catabolic process (GO:0042355)2.66285012
63fucose catabolic process (GO:0019317)2.66285012
64L-fucose metabolic process (GO:0042354)2.66285012
65negative regulation of B cell mediated immunity (GO:0002713)2.65934167
66negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65934167
67histone mRNA catabolic process (GO:0071044)2.65372378
68epithelial cilium movement (GO:0003351)2.62017894
69positive T cell selection (GO:0043368)2.61863645
70negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.61414810
71positive regulation of mast cell activation (GO:0033005)2.61293909
72negative regulation of T-helper cell differentiation (GO:0045623)2.59796543
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59796543
74negative regulation of adaptive immune response (GO:0002820)2.58231934
75negative regulation of glycoprotein metabolic process (GO:1903019)2.57427648
76myeloid cell activation involved in immune response (GO:0002275)2.56027743
77leukocyte degranulation (GO:0043299)2.55706824
78spermatid development (GO:0007286)2.54808343
79protein K48-linked deubiquitination (GO:0071108)2.54073222
80modulation by symbiont of host defense response (GO:0052031)2.53589838
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53589838
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53589838
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.53589838
84modulation by symbiont of host immune response (GO:0052553)2.53589838
85positive regulation by symbiont of host defense response (GO:0052509)2.53589838
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53111026
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.53111026
88regulation of translation, ncRNA-mediated (GO:0045974)2.53111026
89RNA destabilization (GO:0050779)2.51952538
90interferon-gamma production (GO:0032609)2.51573573
91regulation of T cell mediated cytotoxicity (GO:0001914)2.50299660
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48392230
93cellular extravasation (GO:0045123)2.48023582
94protein K63-linked deubiquitination (GO:0070536)2.46282574
95regulation of alpha-beta T cell proliferation (GO:0046640)2.46123917
96tolerance induction (GO:0002507)2.45709259
97regulation of regulatory T cell differentiation (GO:0045589)2.44482700
98lipopolysaccharide metabolic process (GO:0008653)2.44036421
99positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.43840026
100negative regulation of leukocyte mediated immunity (GO:0002704)2.43259674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00368366
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.80484456
3IGF1R_20145208_ChIP-Seq_DFB_Human2.65144490
4GBX2_23144817_ChIP-Seq_PC3_Human2.48197432
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37361647
6ZNF274_21170338_ChIP-Seq_K562_Hela2.37270692
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34346637
8EZH2_22144423_ChIP-Seq_EOC_Human2.25772539
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.14815126
10AR_21572438_ChIP-Seq_LNCaP_Human2.13492931
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03701522
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99684357
13VDR_22108803_ChIP-Seq_LS180_Human1.98423952
14ER_23166858_ChIP-Seq_MCF-7_Human1.94946192
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85937738
16RUNX_20019798_ChIP-Seq_JUKART_Human1.85767001
17P300_19829295_ChIP-Seq_ESCs_Human1.82606612
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76689649
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76184332
20TAF15_26573619_Chip-Seq_HEK293_Human1.74756999
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70294701
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69629489
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69629489
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68474011
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66555121
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61865614
27STAT3_23295773_ChIP-Seq_U87_Human1.61561453
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58420053
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.56593645
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55818157
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.51215642
32PRDM14_20953172_ChIP-Seq_ESCs_Human1.49488990
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48960854
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.48717927
35TCF4_23295773_ChIP-Seq_U87_Human1.48295834
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47646527
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47497933
38CBP_20019798_ChIP-Seq_JUKART_Human1.47497933
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.47246880
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.46092309
41FUS_26573619_Chip-Seq_HEK293_Human1.44492303
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44303571
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43877731
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40527315
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40056737
46AR_25329375_ChIP-Seq_VCAP_Human1.38304942
47SOX2_19829295_ChIP-Seq_ESCs_Human1.34384176
48NANOG_19829295_ChIP-Seq_ESCs_Human1.34384176
49GATA3_26560356_Chip-Seq_TH2_Human1.34223259
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33831613
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32343112
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.28973993
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28662658
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28544243
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24979970
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24808368
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23227493
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22510006
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.20330004
60VDR_24787735_ChIP-Seq_THP-1_Human1.19998920
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.19802283
62BCAT_22108803_ChIP-Seq_LS180_Human1.18096755
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.16968202
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16902130
65RUNX2_22187159_ChIP-Seq_PCA_Human1.16614740
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.15788866
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15549570
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14499397
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12806729
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12628635
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11530648
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11216927
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10669354
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.10374400
75GATA3_27048872_Chip-Seq_THYMUS_Human1.10322262
76DROSHA_22980978_ChIP-Seq_HELA_Human1.10230043
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09701164
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.09065364
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.08803975
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08507909
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07363100
82SCL_19346495_ChIP-Seq_HPC-7_Human1.06468393
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04772550
84SMRT_27268052_Chip-Seq_Bcells_Human1.04722639
85CDX2_22108803_ChIP-Seq_LS180_Human1.04689193
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03594529
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03242336
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02870607
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.02696333
90EWS_26573619_Chip-Seq_HEK293_Human1.01816902
91TCF4_22108803_ChIP-Seq_LS180_Human1.01411214
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01225528
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.00993862
94P53_22387025_ChIP-Seq_ESCs_Mouse1.00414757
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99633391
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98341953
97MYB_26560356_Chip-Seq_TH2_Human0.98302429
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97886635
99IRF8_27001747_Chip-Seq_BMDM_Mouse0.96835086
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96271788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.24564772
2MP0000569_abnormal_digit_pigmentation4.32696104
3MP0003646_muscle_fatigue3.58746742
4MP0003136_yellow_coat_color3.56120442
5MP0005171_absent_coat_pigmentation3.06045744
6MP0003045_fibrosis2.83255934
7MP0004381_abnormal_hair_follicle2.71133639
8MP0002138_abnormal_hepatobiliary_system2.67801308
9MP0003724_increased_susceptibility_to2.55932865
10MP0002653_abnormal_ependyma_morphology2.47924474
11MP0005075_abnormal_melanosome_morpholog2.39528919
12MP0001835_abnormal_antigen_presentation2.24212593
13MP0005410_abnormal_fertilization2.17314198
14MP0005174_abnormal_tail_pigmentation2.05812505
15MP0001800_abnormal_humoral_immune1.98934925
16MP0003890_abnormal_embryonic-extraembry1.97297985
17MP0003879_abnormal_hair_cell1.95150201
18MP0008877_abnormal_DNA_methylation1.88428248
19MP0005377_hearing/vestibular/ear_phenot1.86980520
20MP0003878_abnormal_ear_physiology1.86980520
21MP0001986_abnormal_taste_sensitivity1.77140497
22MP0003763_abnormal_thymus_physiology1.65375331
23MP0001501_abnormal_sleep_pattern1.63685726
24MP0003787_abnormal_imprinting1.58709090
25MP0001486_abnormal_startle_reflex1.50775461
26MP0003195_calcinosis1.45402314
27MP0002723_abnormal_immune_serum1.43319195
28MP0000015_abnormal_ear_pigmentation1.41880375
29MP0000427_abnormal_hair_cycle1.41786575
30MP0004484_altered_response_of1.40080831
31MP0002452_abnormal_antigen_presenting1.39843609
32MP0005387_immune_system_phenotype1.38993855
33MP0001790_abnormal_immune_system1.38993855
34MP0005671_abnormal_response_to1.36164089
35MP0002420_abnormal_adaptive_immunity1.32430597
36MP0005310_abnormal_salivary_gland1.29152690
37MP0001819_abnormal_immune_cell1.28776988
38MP0000685_abnormal_immune_system1.27246845
39MP0002419_abnormal_innate_immunity1.26072633
40MP0003436_decreased_susceptibility_to1.23651735
41MP0009745_abnormal_behavioral_response1.21172068
42MP0005551_abnormal_eye_electrophysiolog1.21056399
43MP0003172_abnormal_lysosome_physiology1.21037168
44MP0005000_abnormal_immune_tolerance1.20320859
45MP0003698_abnormal_male_reproductive1.18910255
46MP0001485_abnormal_pinna_reflex1.14583884
47MP0002277_abnormal_respiratory_mucosa1.13920814
48MP0002095_abnormal_skin_pigmentation1.12202705
49MP0009764_decreased_sensitivity_to1.11989160
50MP0005025_abnormal_response_to1.11425210
51MP0001929_abnormal_gametogenesis1.10445697
52MP0005646_abnormal_pituitary_gland1.08457817
53MP0002332_abnormal_exercise_endurance1.06963747
54MP0002168_other_aberrant_phenotype1.04201889
55MP0001984_abnormal_olfaction1.03463126
56MP0000716_abnormal_immune_system1.02350869
57MP0004043_abnormal_pH_regulation1.00627490
58MP0008057_abnormal_DNA_replication1.00301788
59MP0002272_abnormal_nervous_system1.00105236
60MP0009785_altered_susceptibility_to0.99411741
61MP0004130_abnormal_muscle_cell0.97862831
62MP0000372_irregular_coat_pigmentation0.97714944
63MP0003303_peritoneal_inflammation0.96740485
64MP0002398_abnormal_bone_marrow0.95222172
65MP0003300_gastrointestinal_ulcer0.95194344
66MP0001968_abnormal_touch/_nociception0.95193810
67MP0004147_increased_porphyrin_level0.95034824
68MP0000689_abnormal_spleen_morphology0.93982417
69MP0002254_reproductive_system_inflammat0.93399722
70MP0009046_muscle_twitch0.92867222
71MP0002405_respiratory_system_inflammati0.91837742
72MP0002132_abnormal_respiratory_system0.90755370
73MP0005253_abnormal_eye_physiology0.90490943
74MP0002722_abnormal_immune_system0.90177458
75MP0006082_CNS_inflammation0.89208098
76MP0000749_muscle_degeneration0.89069907
77MP0002229_neurodegeneration0.89048654
78MP0000703_abnormal_thymus_morphology0.87996961
79MP0003635_abnormal_synaptic_transmissio0.81636549
80MP0002064_seizures0.81600044
81MP0004742_abnormal_vestibular_system0.80526162
82MP0002102_abnormal_ear_morphology0.78107685
83MP0002876_abnormal_thyroid_physiology0.77616881
84MP0005085_abnormal_gallbladder_physiolo0.77038891
85MP0002928_abnormal_bile_duct0.76616043
86MP0004142_abnormal_muscle_tone0.75218858
87MP0002396_abnormal_hematopoietic_system0.74016184
88MP0002735_abnormal_chemical_nociception0.73986410
89MP0003828_pulmonary_edema0.73956425
90MP0002148_abnormal_hypersensitivity_rea0.73911009
91MP0005670_abnormal_white_adipose0.73030392
92MP0001845_abnormal_inflammatory_respons0.71051833
93MP0002638_abnormal_pupillary_reflex0.69933171
94MP0008872_abnormal_physiological_respon0.69811052
95MP0005389_reproductive_system_phenotype0.68663848
96MP0001963_abnormal_hearing_physiology0.66798970
97MP0004885_abnormal_endolymph0.66723748
98MP0003633_abnormal_nervous_system0.66224847
99MP0003137_abnormal_impulse_conducting0.65965522
100MP0001970_abnormal_pain_threshold0.65234573

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.55332442
2Amelogenesis imperfecta (HP:0000705)3.54425029
3Stomatitis (HP:0010280)3.50335772
4Stomach cancer (HP:0012126)3.42864321
5Pancreatic cysts (HP:0001737)3.29955992
6Severe visual impairment (HP:0001141)3.22657381
7Attenuation of retinal blood vessels (HP:0007843)3.19541863
8Abnormality of the renal cortex (HP:0011035)3.11130373
9Acanthocytosis (HP:0001927)3.10898974
10Retrobulbar optic neuritis (HP:0100654)3.10101959
11Optic neuritis (HP:0100653)3.10101959
12Abnormality of the renal medulla (HP:0100957)3.07575449
13Chronic hepatic failure (HP:0100626)3.05064990
14Myositis (HP:0100614)3.02867664
15Absent/shortened dynein arms (HP:0200106)3.02693287
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.02693287
17Nephronophthisis (HP:0000090)3.00593391
18Elevated erythrocyte sedimentation rate (HP:0003565)2.98644959
19T lymphocytopenia (HP:0005403)2.89639902
20Recurrent bacterial skin infections (HP:0005406)2.89552077
21Spontaneous hematomas (HP:0007420)2.88156224
22Parakeratosis (HP:0001036)2.81918352
23Abnormality of T cell number (HP:0011839)2.81626533
24Hematochezia (HP:0002573)2.80440985
25Orchitis (HP:0100796)2.64987125
26Hyperventilation (HP:0002883)2.64938984
27Pancreatic fibrosis (HP:0100732)2.64488957
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58515002
29Recurrent abscess formation (HP:0002722)2.56802922
30Gaze-evoked nystagmus (HP:0000640)2.55465704
31Congenital stationary night blindness (HP:0007642)2.53110601
32Bony spicule pigmentary retinopathy (HP:0007737)2.52611278
33Dialeptic seizures (HP:0011146)2.52071886
34Progressive cerebellar ataxia (HP:0002073)2.48543660
35Genetic anticipation (HP:0003743)2.43813473
36Focal seizures (HP:0007359)2.35530248
37Hypochromic microcytic anemia (HP:0004840)2.33238773
38Neoplasm of the adrenal cortex (HP:0100641)2.32568543
39Keratoconjunctivitis (HP:0001096)2.31428569
40Macular degeneration (HP:0000608)2.29069013
41Abolished electroretinogram (ERG) (HP:0000550)2.28957424
42Postural instability (HP:0002172)2.27525581
43Polydipsia (HP:0001959)2.25349261
44Abnormal drinking behavior (HP:0030082)2.25349261
45Abnormal rod and cone electroretinograms (HP:0008323)2.22261160
46Abnormal ciliary motility (HP:0012262)2.20729789
47Poikilocytosis (HP:0004447)2.16939042
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.16845440
49Recurrent skin infections (HP:0001581)2.16137040
50Decreased circulating renin level (HP:0003351)2.13892658
51Abnormal respiratory epithelium morphology (HP:0012253)2.11774834
52Abnormal respiratory motile cilium morphology (HP:0005938)2.11774834
53Widely spaced teeth (HP:0000687)2.10664441
54Recurrent fungal infections (HP:0002841)2.10469572
55Abnormality of macular pigmentation (HP:0008002)2.10232459
56Gastrointestinal infarctions (HP:0005244)2.04273820
57Keratoconjunctivitis sicca (HP:0001097)2.03067502
58Abnormality of T cells (HP:0002843)1.99851516
59Type II lissencephaly (HP:0007260)1.99107269
60Microcytic anemia (HP:0001935)1.98346244
61Hemiplegia (HP:0002301)1.95690417
62Pendular nystagmus (HP:0012043)1.95398351
63Hyperkalemia (HP:0002153)1.95001057
64Autoimmune hemolytic anemia (HP:0001890)1.93596818
65Tubular atrophy (HP:0000092)1.93215968
66Decreased central vision (HP:0007663)1.92639785
67Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91668746
68Enlarged kidneys (HP:0000105)1.91659031
69Vasculitis (HP:0002633)1.91654429
70Papilledema (HP:0001085)1.91262600
71Pulmonary embolism (HP:0002204)1.90733696
72Recurrent cutaneous fungal infections (HP:0011370)1.90244378
73Chronic mucocutaneous candidiasis (HP:0002728)1.90244378
74Cerebellar dysplasia (HP:0007033)1.89828157
75Hypoplastic iliac wings (HP:0002866)1.89123283
76Potter facies (HP:0002009)1.88930930
77Facial shape deformation (HP:0011334)1.88930930
78IgM deficiency (HP:0002850)1.88179851
79Molar tooth sign on MRI (HP:0002419)1.87908008
80Abnormality of midbrain morphology (HP:0002418)1.87908008
81Hemoptysis (HP:0002105)1.87575460
82Thyroiditis (HP:0100646)1.85231211
83Portal hypertension (HP:0001409)1.84360616
84Febrile seizures (HP:0002373)1.83797661
85Progressive inability to walk (HP:0002505)1.83582544
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.83208045
87Broad-based gait (HP:0002136)1.83113451
88Cystic liver disease (HP:0006706)1.82451632
89Eczematoid dermatitis (HP:0000976)1.81534837
90Photophobia (HP:0000613)1.80555834
91Hypoplasia of the thymus (HP:0000778)1.79640249
92Tubulointerstitial nephritis (HP:0001970)1.79607393
93Polyuria (HP:0000103)1.78780328
94Hypochromic anemia (HP:0001931)1.78118162
95Volvulus (HP:0002580)1.77887941
96Recurrent sinusitis (HP:0011108)1.77212081
97Fair hair (HP:0002286)1.76495861
98Metaphyseal dysplasia (HP:0100255)1.76141412
99Encephalitis (HP:0002383)1.75822091
100Absent speech (HP:0001344)1.73989360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.84496110
2LATS15.37402006
3STK38L4.65307980
4TAOK33.00104739
5ACVR1B2.69176199
6STK382.64507221
7RIPK42.06174027
8ZAK1.92316763
9MAP4K11.91592888
10BMPR1B1.90378917
11TXK1.82137883
12PINK11.74530082
13NLK1.71553728
14TNK21.69121872
15LATS21.67176331
16PIK3CG1.62800998
17WNK31.59015104
18MARK31.36982369
19IRAK41.31060871
20PTK2B1.25436592
21GRK11.19523387
22GRK61.17503107
23BRD41.15731983
24BTK1.14581651
25MAP3K21.13327808
26FES1.12952028
27PRKD31.12707261
28FGFR21.09576914
29ADRBK21.09136584
30PLK21.08527484
31IKBKE1.07381714
32BLK1.04835421
33INSRR1.04049281
34SGK21.03251822
35ITK1.02373796
36TEC1.00027364
37SYK0.99456372
38CSK0.96860619
39PLK40.92912504
40MAP4K20.88196504
41MAPK130.87431542
42NTRK30.87236697
43MELK0.87059604
44HCK0.86598391
45KIT0.85950628
46TGFBR20.84647239
47IRAK10.82819733
48DAPK20.78781308
49CDK30.77269864
50CASK0.74575717
51STK110.73939436
52WNK10.73894743
53PRKAA20.71746628
54STK30.71040133
55LYN0.68612794
56JAK20.66328029
57YES10.65098414
58TYK20.64469564
59MAP3K40.63979830
60OXSR10.63298781
61LCK0.62865885
62ADRBK10.62366167
63PDPK10.61279465
64KSR20.60768527
65IKBKB0.59199034
66JAK30.59153447
67SGK4940.58754571
68SGK2230.58754571
69PDK10.57023443
70MAP2K30.56626742
71OBSCN0.55302385
72NUAK10.55259585
73BMPR20.54751970
74SIK20.54282602
75MAPK70.54122981
76MAP2K20.54044565
77MAP3K70.53603199
78PAK30.51445385
79GRK70.50587630
80GRK50.49526409
81PRKCQ0.48887541
82MAP3K10.48494406
83FGR0.48129442
84SGK30.46863490
85TGFBR10.46599053
86ZAP700.45616499
87PIM10.44857716
88TAOK10.43220350
89CSF1R0.42306180
90JAK10.39734337
91PRKD10.39333420
92SGK10.38758062
93MKNK20.37506667
94TLK10.36952620
95WNK40.36664119
96CAMK40.36167383
97CAMK10.35097347
98MATK0.34469076
99MAP3K130.33535360
100ABL10.31963803

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82950938
2Dorso-ventral axis formation_Homo sapiens_hsa043202.55577016
3Nicotine addiction_Homo sapiens_hsa050332.20608155
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05871049
5Taste transduction_Homo sapiens_hsa047421.88777742
6Allograft rejection_Homo sapiens_hsa053301.78232289
7Graft-versus-host disease_Homo sapiens_hsa053321.77342407
8Autoimmune thyroid disease_Homo sapiens_hsa053201.77053287
9Morphine addiction_Homo sapiens_hsa050321.76490537
10Osteoclast differentiation_Homo sapiens_hsa043801.67784952
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64815297
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62759183
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61939942
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.52482731
15Type I diabetes mellitus_Homo sapiens_hsa049401.51741686
16Leishmaniasis_Homo sapiens_hsa051401.50769788
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49693336
18Fatty acid biosynthesis_Homo sapiens_hsa000611.49688653
19Primary immunodeficiency_Homo sapiens_hsa053401.47477008
20Olfactory transduction_Homo sapiens_hsa047401.42556583
21T cell receptor signaling pathway_Homo sapiens_hsa046601.41526195
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39540189
23Staphylococcus aureus infection_Homo sapiens_hsa051501.38229024
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36827083
25Tuberculosis_Homo sapiens_hsa051521.35453464
26Asthma_Homo sapiens_hsa053101.33978294
27ABC transporters_Homo sapiens_hsa020101.33666295
28B cell receptor signaling pathway_Homo sapiens_hsa046621.32893013
29Nitrogen metabolism_Homo sapiens_hsa009101.30788816
30Sphingolipid metabolism_Homo sapiens_hsa006001.25670734
31Hematopoietic cell lineage_Homo sapiens_hsa046401.20703820
32GABAergic synapse_Homo sapiens_hsa047271.19579503
33Calcium signaling pathway_Homo sapiens_hsa040201.18276298
34Circadian entrainment_Homo sapiens_hsa047131.15575660
35Glutamatergic synapse_Homo sapiens_hsa047241.14417342
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.13302503
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12550323
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06319076
39Viral myocarditis_Homo sapiens_hsa054161.05427810
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.05413908
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04465651
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01188366
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00858545
44Serotonergic synapse_Homo sapiens_hsa047260.98092544
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97613900
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97152437
47Type II diabetes mellitus_Homo sapiens_hsa049300.93864639
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91567961
49Measles_Homo sapiens_hsa051620.89933874
50Basal transcription factors_Homo sapiens_hsa030220.87067479
51Platelet activation_Homo sapiens_hsa046110.86688421
52Salivary secretion_Homo sapiens_hsa049700.86370250
53Chemokine signaling pathway_Homo sapiens_hsa040620.85368045
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83688152
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.82679876
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81913791
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80604254
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80337629
59Glycerolipid metabolism_Homo sapiens_hsa005610.80158248
60Linoleic acid metabolism_Homo sapiens_hsa005910.79788677
61FoxO signaling pathway_Homo sapiens_hsa040680.79212927
62cAMP signaling pathway_Homo sapiens_hsa040240.77478527
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.76767282
64Renin secretion_Homo sapiens_hsa049240.76638740
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76107851
66Antigen processing and presentation_Homo sapiens_hsa046120.74695151
67Oxytocin signaling pathway_Homo sapiens_hsa049210.74421898
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.72651207
69Butanoate metabolism_Homo sapiens_hsa006500.72284208
70Regulation of autophagy_Homo sapiens_hsa041400.70615200
71Cholinergic synapse_Homo sapiens_hsa047250.69977776
72Inositol phosphate metabolism_Homo sapiens_hsa005620.69207597
73Circadian rhythm_Homo sapiens_hsa047100.68820161
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68715212
75Influenza A_Homo sapiens_hsa051640.68367833
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66287463
77Herpes simplex infection_Homo sapiens_hsa051680.65784577
78VEGF signaling pathway_Homo sapiens_hsa043700.65045982
79Ether lipid metabolism_Homo sapiens_hsa005650.64246616
80Toxoplasmosis_Homo sapiens_hsa051450.63765861
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62454163
82African trypanosomiasis_Homo sapiens_hsa051430.62421586
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61936102
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.60733379
85Insulin secretion_Homo sapiens_hsa049110.60469337
86Gastric acid secretion_Homo sapiens_hsa049710.59211492
87Long-term potentiation_Homo sapiens_hsa047200.58197173
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57267200
89MAPK signaling pathway_Homo sapiens_hsa040100.56841225
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56478191
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54963567
92Legionellosis_Homo sapiens_hsa051340.50964712
93Malaria_Homo sapiens_hsa051440.49794036
94Long-term depression_Homo sapiens_hsa047300.48885062
95Amphetamine addiction_Homo sapiens_hsa050310.48765120
96Acute myeloid leukemia_Homo sapiens_hsa052210.48123572
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47667769
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.46614560
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.45431351
100Ovarian steroidogenesis_Homo sapiens_hsa049130.44989929

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