ADAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.85295747
2dosage compensation (GO:0007549)4.73516756
3DNA deamination (GO:0045006)4.51603908
4NIK/NF-kappaB signaling (GO:0038061)4.32845852
5somatic hypermutation of immunoglobulin genes (GO:0016446)4.27202990
6somatic diversification of immune receptors via somatic mutation (GO:0002566)4.27202990
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.26260843
8proteasome assembly (GO:0043248)4.18881243
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.08637724
10response to peptidoglycan (GO:0032494)3.92305653
11formation of translation preinitiation complex (GO:0001731)3.75164508
12pyrimidine nucleoside salvage (GO:0043097)3.73331177
13pyrimidine-containing compound salvage (GO:0008655)3.73331177
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.70043829
15transcription from mitochondrial promoter (GO:0006390)3.67835723
16maturation of SSU-rRNA (GO:0030490)3.67072263
17oxygen transport (GO:0015671)3.66251761
18regulation of transcription from RNA polymerase I promoter (GO:0006356)3.63415427
19spliceosomal snRNP assembly (GO:0000387)3.57195812
20folic acid metabolic process (GO:0046655)3.55013330
21ribosome biogenesis (GO:0042254)3.51943645
22amino acid salvage (GO:0043102)3.49689749
23L-methionine salvage (GO:0071267)3.49689749
24L-methionine biosynthetic process (GO:0071265)3.49689749
25positive thymic T cell selection (GO:0045059)3.49659741
26viral transcription (GO:0019083)3.47063854
27translational termination (GO:0006415)3.45562773
28peptidyl-arginine omega-N-methylation (GO:0035247)3.45470839
29mitotic nuclear envelope reassembly (GO:0007084)3.38104199
30nuclear envelope reassembly (GO:0031468)3.38104199
31translational elongation (GO:0006414)3.34591656
32apoptotic process involved in morphogenesis (GO:0060561)3.33688760
33meiotic chromosome segregation (GO:0045132)3.33562205
34rRNA processing (GO:0006364)3.32152108
35DNA strand elongation involved in DNA replication (GO:0006271)3.30458894
36rRNA metabolic process (GO:0016072)3.29979361
37positive regulation of gamma-delta T cell activation (GO:0046645)3.27714955
38ribosomal small subunit biogenesis (GO:0042274)3.27507658
39negative regulation of erythrocyte differentiation (GO:0045647)3.24008561
40viral mRNA export from host cell nucleus (GO:0046784)3.23690545
41L-serine metabolic process (GO:0006563)3.23338266
42regulation of gamma-delta T cell differentiation (GO:0045586)3.23014301
43ribonucleoprotein complex biogenesis (GO:0022613)3.22199655
44ribosome assembly (GO:0042255)3.20631668
45regulation of spindle organization (GO:0090224)3.19562308
46methionine biosynthetic process (GO:0009086)3.17041572
47resolution of meiotic recombination intermediates (GO:0000712)3.15676229
48cellular response to arsenic-containing substance (GO:0071243)3.15245735
49GDP-mannose metabolic process (GO:0019673)3.14647396
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14252760
51proline biosynthetic process (GO:0006561)3.14062599
52DNA damage response, signal transduction resulting in transcription (GO:0042772)3.13664776
53DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.13121384
54negative regulation of myeloid cell apoptotic process (GO:0033033)3.12658492
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12234374
56translational initiation (GO:0006413)3.11026902
57positive regulation of developmental pigmentation (GO:0048087)3.10406608
58DNA strand elongation (GO:0022616)3.10218246
59DNA replication initiation (GO:0006270)3.09199116
60metaphase plate congression (GO:0051310)3.07624704
61interferon-gamma secretion (GO:0072643)3.06296682
62folic acid transport (GO:0015884)3.06154384
63snRNA processing (GO:0016180)3.05035532
64leukocyte aggregation (GO:0070486)3.04629470
65regulation of chromatin binding (GO:0035561)3.03768413
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03375764
67UV protection (GO:0009650)3.03148643
68intracellular estrogen receptor signaling pathway (GO:0030520)3.01332745
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00616611
70histone H3-K4 trimethylation (GO:0080182)2.99409184
71histone arginine methylation (GO:0034969)2.98712822
72rRNA transcription (GO:0009303)2.97522628
73negative regulation of interleukin-12 production (GO:0032695)2.96323015
74ribosomal small subunit assembly (GO:0000028)2.96022113
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94341882
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91090205
77cotranslational protein targeting to membrane (GO:0006613)2.90483818
78pentose-phosphate shunt (GO:0006098)2.89885515
79modulation by symbiont of host defense response (GO:0052031)2.88616281
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88616281
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88616281
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.88616281
83modulation by symbiont of host immune response (GO:0052553)2.88616281
84positive regulation by symbiont of host defense response (GO:0052509)2.88616281
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.88369222
86termination of RNA polymerase III transcription (GO:0006386)2.88369222
87branching involved in mammary gland duct morphogenesis (GO:0060444)2.88044690
88protein targeting to ER (GO:0045047)2.88025318
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87133624
90snRNA metabolic process (GO:0016073)2.84922382
91DNA replication-dependent nucleosome assembly (GO:0006335)2.84590687
92DNA replication-dependent nucleosome organization (GO:0034723)2.84590687
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83738385
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83489535
95negative regulation of ligase activity (GO:0051352)2.83191992
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83191992
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81611228
98oxidative demethylation (GO:0070989)2.81273969
99cellular protein complex disassembly (GO:0043624)2.80771621
100regulation of mitotic spindle organization (GO:0060236)2.80523394
101lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79889889
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79393617
103nucleobase biosynthetic process (GO:0046112)2.78655040
1043-UTR-mediated mRNA stabilization (GO:0070935)2.78448593
105response to interleukin-4 (GO:0070670)2.77657710
106peptidyl-arginine methylation (GO:0018216)2.77142513
107peptidyl-arginine N-methylation (GO:0035246)2.77142513
108chaperone mediated protein folding requiring cofactor (GO:0051085)2.77122377
109telomere maintenance via semi-conservative replication (GO:0032201)2.77090317
110pseudouridine synthesis (GO:0001522)2.76676127
111ribosomal large subunit biogenesis (GO:0042273)2.76501944
112eosinophil chemotaxis (GO:0048245)2.75381289
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74946731
114regulation of translational termination (GO:0006449)2.74764483
115modulation by symbiont of host cellular process (GO:0044068)2.74477861
116regulation of apoptotic process involved in morphogenesis (GO:1902337)2.74458496
117regulation of chemokine biosynthetic process (GO:0045073)2.74423153
118protein complex disassembly (GO:0043241)2.72048218
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71101840
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71101840
121viral life cycle (GO:0019058)2.70961598
122negative regulation of stress fiber assembly (GO:0051497)2.70866622
123translation (GO:0006412)2.70726726
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70110112
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69535660
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69535660
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69535660
128regulation of gamma-delta T cell activation (GO:0046643)2.69384087
129* ncRNA processing (GO:0034470)2.69147951
130signal transduction involved in DNA damage checkpoint (GO:0072422)2.69078711
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69078711
132regulation of histone H3-K4 methylation (GO:0051569)2.69017382
133protein localization to endoplasmic reticulum (GO:0070972)2.68905661
134negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.68567129
135COPI coating of Golgi vesicle (GO:0048205)2.68564815
136Golgi transport vesicle coating (GO:0048200)2.68564815
137negative regulation by host of viral transcription (GO:0043922)2.68108347
138modulation by virus of host process (GO:0019054)2.67885594
139transcription elongation from RNA polymerase I promoter (GO:0006362)2.67797631
140negative regulation of mRNA processing (GO:0050686)2.66950833
141aspartate family amino acid biosynthetic process (GO:0009067)2.66939905
142nucleotide salvage (GO:0043173)2.66113111
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.65669661
144double-strand break repair via nonhomologous end joining (GO:0006303)2.65575702
145non-recombinational repair (GO:0000726)2.65575702
146myeloid dendritic cell differentiation (GO:0043011)2.65003241
147DNA unwinding involved in DNA replication (GO:0006268)2.61276509
148pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.61069560
149negative regulation of cell size (GO:0045792)2.55820486
150T cell apoptotic process (GO:0070231)2.55814093
151regulation of superoxide anion generation (GO:0032928)2.52832057
152pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51023531
153tRNA methylation (GO:0030488)2.49511597
154pinocytosis (GO:0006907)2.49470693
155glycosphingolipid catabolic process (GO:0046479)2.49022147
156amino sugar catabolic process (GO:0046348)2.48812214
157protein insertion into membrane (GO:0051205)2.48735810
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48310929
159pyrimidine nucleotide catabolic process (GO:0006244)2.48154089
160negative regulation of viral release from host cell (GO:1902187)2.48100662
161immunoglobulin mediated immune response (GO:0016064)2.47610445
162NADPH regeneration (GO:0006740)2.47430323
163adhesion of symbiont to host (GO:0044406)2.46541952
164glucose catabolic process (GO:0006007)2.43438381
165iron-sulfur cluster assembly (GO:0016226)2.43413655
166metallo-sulfur cluster assembly (GO:0031163)2.43413655
167protein localization to endosome (GO:0036010)2.41820306
168positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.41540075
169response to muramyl dipeptide (GO:0032495)2.41489132
170mitotic chromosome condensation (GO:0007076)2.38931660
171positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37577229
172pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.36991837
173negative regulation of B cell apoptotic process (GO:0002903)2.36757085
174mannose metabolic process (GO:0006013)2.35172135
175pentose metabolic process (GO:0019321)2.35007690
176positive regulation of Cdc42 GTPase activity (GO:0043089)2.34935021
177barbed-end actin filament capping (GO:0051016)2.34157462
178regulation of early endosome to late endosome transport (GO:2000641)2.33295262
179nucleoside salvage (GO:0043174)2.33255487
180positive regulation of chemokine biosynthetic process (GO:0045080)2.33092669
181base-excision repair, AP site formation (GO:0006285)2.32589682
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31017474
183myeloid dendritic cell activation (GO:0001773)2.29450371
184defense response to protozoan (GO:0042832)2.24555328
185adhesion of symbiont to host cell (GO:0044650)2.24303782
186virion attachment to host cell (GO:0019062)2.24303782
187leukocyte apoptotic process (GO:0071887)2.23969288
188response to protozoan (GO:0001562)2.23626938
189regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.23563587
190macrophage activation involved in immune response (GO:0002281)2.23160202
191deoxyribonucleotide catabolic process (GO:0009264)2.22321302
192regulation of NFAT protein import into nucleus (GO:0051532)2.22221370
193apoptotic process involved in development (GO:1902742)2.21535043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06457540
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06508235
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70188922
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19495237
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95372348
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87136984
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72533120
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.70127044
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.67767469
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60650385
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.56996882
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56027668
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.44616113
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36126470
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32403204
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31712606
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26434301
18XRN2_22483619_ChIP-Seq_HELA_Human2.24967295
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.22395820
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20930622
21MYC_22102868_ChIP-Seq_BL_Human2.20002776
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19965813
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.15470071
24VDR_23849224_ChIP-Seq_CD4+_Human2.09328561
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.09228161
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08423367
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96533113
28ZNF263_19887448_ChIP-Seq_K562_Human1.93125972
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86147909
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85491980
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84824406
32VDR_21846776_ChIP-Seq_THP-1_Human1.84386238
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84015758
34GABP_19822575_ChIP-Seq_HepG2_Human1.81043352
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79938671
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78413392
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77348299
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75513497
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75072185
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75072185
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75072185
42* RACK7_27058665_Chip-Seq_MCF-7_Human1.74623369
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71886929
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68802834
45FOXP3_21729870_ChIP-Seq_TREG_Human1.68764226
46KDM2B_26808549_Chip-Seq_DND41_Human1.68255079
47VDR_24763502_ChIP-Seq_THP-1_Human1.67712526
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67496807
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62237438
50TTF2_22483619_ChIP-Seq_HELA_Human1.60320084
51DCP1A_22483619_ChIP-Seq_HELA_Human1.60238782
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58968776
53AR_21909140_ChIP-Seq_LNCAP_Human1.58570814
54P68_20966046_ChIP-Seq_HELA_Human1.57748470
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54549285
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52822956
57CIITA_25753668_ChIP-Seq_RAJI_Human1.52588433
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.51743500
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51210436
60TCF7_22412390_ChIP-Seq_EML_Mouse1.48598794
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47090315
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46304779
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45652609
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45378664
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.44785265
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43570723
67KDM5A_27292631_Chip-Seq_BREAST_Human1.42870166
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42769176
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42168273
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39961743
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.39743469
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39151644
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38334239
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38167706
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37866044
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37016496
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.36917258
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34070887
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.32696738
80BCOR_27268052_Chip-Seq_Bcells_Human1.30956729
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.30490459
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29403175
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28331565
84BCL6_27268052_Chip-Seq_Bcells_Human1.26181918
85TFEB_21752829_ChIP-Seq_HELA_Human1.26022116
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.24495962
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24287476
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21167875
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20985665
90NCOR1_26117541_ChIP-Seq_K562_Human1.20961976
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20639008
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.19740336
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18504171
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18298738
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17565909
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16736402
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16374298
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16216485
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.16124866
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15642733
101MAF_26560356_Chip-Seq_TH2_Human1.15579111
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.15046577
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14482433
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13645897
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.13528305
106* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12652059
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.12337688
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12331617
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11624789
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.11458356
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11241494
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10289956
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08319636
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07862914
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.07526203
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07037202
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06880788
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06501137
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06227023
120KDM2B_26808549_Chip-Seq_K562_Human1.05757507
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05419698
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05199364
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04970079
124SMC4_20622854_ChIP-Seq_HELA_Human1.04151201
125PHF8_20622854_ChIP-Seq_HELA_Human1.03312685
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.03311395
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02824817
128CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02684681
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01761735
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01591313
131STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00725292
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00715137
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99307987
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99084469
135MAF_26560356_Chip-Seq_TH1_Human0.98909636
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98613100
137SPI1_23547873_ChIP-Seq_NB4_Human0.97798479
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97608722
139* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97089574
140* UTX_26944678_Chip-Seq_JUKART_Human0.96884946
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95606476
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94805521
143* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93617329
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93479858
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93242154
146STAT1_20625510_ChIP-Seq_HELA_Human0.91913585
147LXR_22292898_ChIP-Seq_THP-1_Human0.91385996
148* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90845942
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90460707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26368326
2MP0005058_abnormal_lysosome_morphology4.12140128
3MP0003111_abnormal_nucleus_morphology3.79667395
4MP0010094_abnormal_chromosome_stability3.48071386
5MP0002396_abnormal_hematopoietic_system3.39084429
6MP0005451_abnormal_body_composition3.18778742
7MP0004957_abnormal_blastocyst_morpholog3.15541260
8MP0003077_abnormal_cell_cycle3.07394470
9MP0003303_peritoneal_inflammation3.00817192
10MP0003172_abnormal_lysosome_physiology2.94660741
11MP0008057_abnormal_DNA_replication2.87677380
12MP0004264_abnormal_extraembryonic_tissu2.75293531
13MP0008058_abnormal_DNA_repair2.69286986
14MP0005671_abnormal_response_to2.62677544
15MP0003786_premature_aging2.58503077
16MP0008260_abnormal_autophagy2.44928726
17MP0000685_abnormal_immune_system2.41549755
18MP0010030_abnormal_orbit_morphology2.17894319
19MP0003705_abnormal_hypodermis_morpholog2.14825889
20MP0004858_abnormal_nervous_system2.09590445
21MP0008932_abnormal_embryonic_tissue2.07427825
22MP0005076_abnormal_cell_differentiation2.05092166
23MP0003763_abnormal_thymus_physiology2.01386699
24MP0003315_abnormal_perineum_morphology1.98966743
25MP0009333_abnormal_splenocyte_physiolog1.96907458
26MP0000350_abnormal_cell_proliferation1.91297771
27MP0001730_embryonic_growth_arrest1.88255392
28MP0000678_abnormal_parathyroid_gland1.85607828
29MP0008007_abnormal_cellular_replicative1.82408076
30MP0003453_abnormal_keratinocyte_physiol1.79564930
31MP0000490_abnormal_crypts_of1.79548174
32MP0005075_abnormal_melanosome_morpholog1.79405992
33MP0003191_abnormal_cellular_cholesterol1.75354743
34MP0004185_abnormal_adipocyte_glucose1.73427892
35MP0004233_abnormal_muscle_weight1.73404811
36MP0003300_gastrointestinal_ulcer1.69405799
37MP0002009_preneoplasia1.68164945
38MP0000465_gastrointestinal_hemorrhage1.67042406
39MP0002419_abnormal_innate_immunity1.65729851
40MP0002877_abnormal_melanocyte_morpholog1.65356976
41MP0002398_abnormal_bone_marrow1.65083842
42MP0005025_abnormal_response_to1.64937817
43MP0003567_abnormal_fetal_cardiomyocyte1.63688748
44MP0000537_abnormal_urethra_morphology1.60121247
45MP0000703_abnormal_thymus_morphology1.59083502
46MP0002166_altered_tumor_susceptibility1.57393450
47MP0004808_abnormal_hematopoietic_stem1.56929773
48MP0002722_abnormal_immune_system1.56667807
49MP0002254_reproductive_system_inflammat1.56174150
50MP0002148_abnormal_hypersensitivity_rea1.55139651
51MP0001849_ear_inflammation1.54432069
52MP0004133_heterotaxia1.53932710
53MP0001790_abnormal_immune_system1.51174063
54MP0005387_immune_system_phenotype1.51174063
55MP0001697_abnormal_embryo_size1.48864014
56MP0000689_abnormal_spleen_morphology1.48202331
57MP0001873_stomach_inflammation1.46420529
58MP0001835_abnormal_antigen_presentation1.46285112
59MP0004947_skin_inflammation1.44522588
60MP0009785_altered_susceptibility_to1.43211945
61MP0004510_myositis1.42620808
62MP0002019_abnormal_tumor_incidence1.40979660
63MP0000313_abnormal_cell_death1.36601132
64MP0001672_abnormal_embryogenesis/_devel1.35611609
65MP0005380_embryogenesis_phenotype1.35611609
66MP0002080_prenatal_lethality1.33403878
67MP0002429_abnormal_blood_cell1.31144652
68MP0000716_abnormal_immune_system1.30675959
69MP0005501_abnormal_skin_physiology1.29787786
70MP0002796_impaired_skin_barrier1.28661197
71MP0001533_abnormal_skeleton_physiology1.27122321
72MP0002998_abnormal_bone_remodeling1.25862060
73MP0006082_CNS_inflammation1.24702027
74MP0000343_altered_response_to1.23806273
75MP0001727_abnormal_embryo_implantation1.21276803
76MP0003075_altered_response_to1.21061207
77MP0003866_abnormal_defecation1.20827979
78MP0005023_abnormal_wound_healing1.18323722
79MP0001293_anophthalmia1.17795771
80MP0005623_abnormal_meninges_morphology1.17658658
81MP0006072_abnormal_retinal_apoptosis1.17293151
82MP0002405_respiratory_system_inflammati1.17213810
83MP0003436_decreased_susceptibility_to1.16836139
84MP0002088_abnormal_embryonic_growth/wei1.16673511
85MP0002085_abnormal_embryonic_tissue1.16635516
86MP0003718_maternal_effect1.16564230
87MP0000681_abnormal_thyroid_gland1.16445286
88MP0005666_abnormal_adipose_tissue1.15017975
89MP0003984_embryonic_growth_retardation1.14607873
90MP0001800_abnormal_humoral_immune1.14235187
91MP0001346_abnormal_lacrimal_gland1.11436361
92MP0009053_abnormal_anal_canal1.11108833
93MP0002086_abnormal_extraembryonic_tissu1.09955155
94MP0008789_abnormal_olfactory_epithelium1.07179955
95MP0001984_abnormal_olfaction1.05886528
96MP0002723_abnormal_immune_serum1.05500581
97MP0008995_early_reproductive_senescence1.04965691
98MP0005375_adipose_tissue_phenotype1.04063178
99MP0002277_abnormal_respiratory_mucosa1.03181376
100MP0008469_abnormal_protein_level1.02501157
101MP0002420_abnormal_adaptive_immunity1.02287046
102MP0004197_abnormal_fetal_growth/weight/1.01535676
103MP0002249_abnormal_larynx_morphology1.01390811
104MP0009840_abnormal_foam_cell1.00984327
105MP0001819_abnormal_immune_cell1.00601574
106MP0002084_abnormal_developmental_patter1.00141816
107MP0001853_heart_inflammation0.99041377
108MP0010307_abnormal_tumor_latency0.97090310
109MP0000003_abnormal_adipose_tissue0.96489890
110MP0008770_decreased_survivor_rate0.96041528
111MP0001845_abnormal_inflammatory_respons0.95865238
112MP0003122_maternal_imprinting0.94450373
113MP0002933_joint_inflammation0.93511652
114MP0002006_tumorigenesis0.92783910
115MP0005310_abnormal_salivary_gland0.92072798
116MP0002098_abnormal_vibrissa_morphology0.91930814
117MP0000358_abnormal_cell_content/0.91228402
118MP0003119_abnormal_digestive_system0.87324447
119MP0005621_abnormal_cell_physiology0.87184066
120MP0008877_abnormal_DNA_methylation0.86357714
121MP0000750_abnormal_muscle_regeneration0.85159665
122MP0005464_abnormal_platelet_physiology0.84047127
123MP0002452_abnormal_antigen_presenting0.82030805
124MP0005384_cellular_phenotype0.81879742
125MP0001243_abnormal_dermal_layer0.80690341
126MP0010155_abnormal_intestine_physiology0.80604024
127MP0003448_altered_tumor_morphology0.80441458
128MP0005390_skeleton_phenotype0.80132370
129MP0002653_abnormal_ependyma_morphology0.78965968
130MP0009931_abnormal_skin_appearance0.78757084
131MP0005397_hematopoietic_system_phenotyp0.78737814
132MP0001545_abnormal_hematopoietic_system0.78737814
133MP0002210_abnormal_sex_determination0.78391731
134MP0004381_abnormal_hair_follicle0.77991324
135MP0003121_genomic_imprinting0.77865006
136MP0003221_abnormal_cardiomyocyte_apopto0.75424022
137MP0000604_amyloidosis0.73882254
138MP0009764_decreased_sensitivity_to0.73746210
139MP0002132_abnormal_respiratory_system0.72848272
140MP0001929_abnormal_gametogenesis0.72417944
141MP0002092_abnormal_eye_morphology0.71684985
142MP0001145_abnormal_male_reproductive0.70113654
143MP0003566_abnormal_cell_adhesion0.69951191
144MP0000477_abnormal_intestine_morphology0.69941092
145MP0009278_abnormal_bone_marrow0.69855699
146MP0005266_abnormal_metabolism0.68505847
147MP0002089_abnormal_postnatal_growth/wei0.68053535
148MP0003115_abnormal_respiratory_system0.66030059
149MP0000858_altered_metastatic_potential0.64941462
150MP0005000_abnormal_immune_tolerance0.64669993
151MP0000733_abnormal_muscle_development0.63971519
152MP0002234_abnormal_pharynx_morphology0.62816313

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)5.14580726
2Abnormality of glycolipid metabolism (HP:0010969)4.63450344
3Abnormality of liposaccharide metabolism (HP:0010968)4.63450344
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.63450344
5Ependymoma (HP:0002888)4.51942842
6Cerebral hypomyelination (HP:0006808)4.42348846
7Broad distal phalanx of finger (HP:0009836)4.24584512
8Carpal bone hypoplasia (HP:0001498)3.62272723
9Urethral obstruction (HP:0000796)3.54475486
10Ulnar bowing (HP:0003031)3.53599737
11Loss of speech (HP:0002371)3.52807979
12Increased cerebral lipofuscin (HP:0011813)3.45226113
13Petechiae (HP:0000967)3.44890793
14Agnosia (HP:0010524)3.38994078
15Dysostosis multiplex (HP:0000943)3.33710470
16Abnormal number of erythroid precursors (HP:0012131)3.28679223
17Abnormality of cells of the erythroid lineage (HP:0012130)3.27198540
18Selective tooth agenesis (HP:0001592)3.19794107
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.19516033
20Basal cell carcinoma (HP:0002671)3.14040289
21Medulloblastoma (HP:0002885)3.13328404
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.03747168
23Birth length less than 3rd percentile (HP:0003561)2.99240745
24Abnormality of the phalanges of the hallux (HP:0010057)2.97969544
25Abnormality of the distal phalanges of the toes (HP:0010182)2.97325605
26Neoplasm of the oral cavity (HP:0100649)2.90918447
27Abnormality of the anterior horn cell (HP:0006802)2.87570951
28Degeneration of anterior horn cells (HP:0002398)2.87570951
29Patellar aplasia (HP:0006443)2.86706614
30Ragged-red muscle fibers (HP:0003200)2.84332351
31Pustule (HP:0200039)2.84193673
32Vacuolated lymphocytes (HP:0001922)2.76203654
33Increased serum ferritin (HP:0003281)2.76201960
34Abnormality of the preputium (HP:0100587)2.76187589
35Achilles tendon contracture (HP:0001771)2.72209374
36Aplasia/Hypoplasia of the patella (HP:0006498)2.71894572
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.69065001
38IgM deficiency (HP:0002850)2.66994808
39Abnormality of the astrocytes (HP:0100707)2.65286989
40Astrocytoma (HP:0009592)2.65286989
41Recurrent abscess formation (HP:0002722)2.64644027
42Abnormality of alanine metabolism (HP:0010916)2.64269175
43Hyperalaninemia (HP:0003348)2.64269175
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64269175
45Breast hypoplasia (HP:0003187)2.61308412
46Horseshoe kidney (HP:0000085)2.60822531
47Abnormality of the fetal cardiovascular system (HP:0010948)2.58592025
48Abnormal umbilical cord blood vessels (HP:0011403)2.58592025
49Single umbilical artery (HP:0001195)2.58592025
50Abnormal number of incisors (HP:0011064)2.58406996
51Recurrent bacterial skin infections (HP:0005406)2.58332459
52Abnormality of the fingertips (HP:0001211)2.57305948
53Hypoplastic pelvis (HP:0008839)2.55646899
54Abnormality of the ileum (HP:0001549)2.55387634
55Prominent nose (HP:0000448)2.53854537
56Meckel diverticulum (HP:0002245)2.53585978
57Abnormality of macrophages (HP:0004311)2.53316828
58Eczematoid dermatitis (HP:0000976)2.52794714
59Abnormality of the thoracic spine (HP:0100711)2.50844397
60Amaurosis fugax (HP:0100576)2.50665246
61Hypertensive crisis (HP:0100735)2.50432175
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48823445
63Abnormality of polysaccharide metabolism (HP:0011012)2.48823445
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48823445
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.48278981
66Abnormal gallbladder physiology (HP:0012438)2.47552442
67Cholecystitis (HP:0001082)2.47552442
68Stridor (HP:0010307)2.45284558
69Reticulocytopenia (HP:0001896)2.43412604
70Microvesicular hepatic steatosis (HP:0001414)2.41875172
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.37017851
72Mediastinal lymphadenopathy (HP:0100721)2.35535030
73Hyperacusis (HP:0010780)2.34803564
74Renal duplication (HP:0000075)2.31824423
75Insomnia (HP:0100785)2.30601645
76Abnormality of the labia minora (HP:0012880)2.29528494
77Abnormality of the Achilles tendon (HP:0005109)2.29234382
78Lymphoma (HP:0002665)2.27998678
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27735167
80Asplenia (HP:0001746)2.25798048
81Vertebral compression fractures (HP:0002953)2.25539875
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25028096
83Absent thumb (HP:0009777)2.23483306
84Cellulitis (HP:0100658)2.21715945
85Upper motor neuron abnormality (HP:0002127)2.21436634
86Chronic obstructive pulmonary disease (HP:0006510)2.21414286
87Obstructive lung disease (HP:0006536)2.21414286
88Nuclear cataract (HP:0100018)2.20364078
89Septate vagina (HP:0001153)2.19073259
90Thoracic kyphosis (HP:0002942)2.18754011
91Abnormality of glycolysis (HP:0004366)2.18192770
92Increased serum pyruvate (HP:0003542)2.18192770
93Abnormal trabecular bone morphology (HP:0100671)2.15180155
94Urinary glycosaminoglycan excretion (HP:0003541)2.15081948
95Mucopolysacchariduria (HP:0008155)2.15081948
96Vaginal fistula (HP:0004320)2.14528091
97Supernumerary spleens (HP:0009799)2.13218263
98Neuronal loss in central nervous system (HP:0002529)2.12991970
99Macrocytic anemia (HP:0001972)2.12547138
100Axonal loss (HP:0003447)2.11827676
101Long palpebral fissure (HP:0000637)2.10506202
102Myelodysplasia (HP:0002863)2.09527853
103Rhabdomyosarcoma (HP:0002859)2.09171099
104Sloping forehead (HP:0000340)2.08213402
105Glioma (HP:0009733)2.07900835
106Hepatosplenomegaly (HP:0001433)2.05544593
107Gastrointestinal stroma tumor (HP:0100723)2.05313928
108Adenoma sebaceum (HP:0009720)2.05217424
109Angiofibromas (HP:0010615)2.05217424
110Progressive muscle weakness (HP:0003323)2.05211843
111Bowel diverticulosis (HP:0005222)2.05008133
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04557178
113Prolonged neonatal jaundice (HP:0006579)2.04247820
114Absent radius (HP:0003974)2.04141925
115Pallor (HP:0000980)2.04073186
116Neoplasm of the pancreas (HP:0002894)2.01412503
117Purpura (HP:0000979)2.01330495
118Broad face (HP:0000283)2.01182207
119Aplasia/Hypoplasia of the spleen (HP:0010451)2.00734369
120Systemic lupus erythematosus (HP:0002725)2.00299119
121Colitis (HP:0002583)1.99959635
122Aplasia involving forearm bones (HP:0009822)1.99731552
123Absent forearm bone (HP:0003953)1.99731552
124Triphalangeal thumb (HP:0001199)1.99028552
125Nonimmune hydrops fetalis (HP:0001790)1.97789243
126Rough bone trabeculation (HP:0100670)1.95574984
127Abnormality of the umbilical cord (HP:0010881)1.93193015
128Alopecia of scalp (HP:0002293)1.92864902
129Multiple enchondromatosis (HP:0005701)1.92297764
130Short 5th finger (HP:0009237)1.91974903
131Abnormality of the carotid arteries (HP:0005344)1.91970572
132Testicular atrophy (HP:0000029)1.91451806
133Personality changes (HP:0000751)1.90695609
134CNS hypomyelination (HP:0003429)1.90452719
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.88220696
136Small intestinal stenosis (HP:0012848)1.88059291
137Duodenal stenosis (HP:0100867)1.88059291
138Abnormality of the nasal mucosa (HP:0000433)1.87894873
139Seborrheic dermatitis (HP:0001051)1.87812531
140Oral leukoplakia (HP:0002745)1.87212464
141Distal lower limb muscle weakness (HP:0009053)1.86949025
142Intestinal fistula (HP:0100819)1.86696083
143Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86317491
144Premature ovarian failure (HP:0008209)1.86222554
145Overriding aorta (HP:0002623)1.86148320
146Neoplasm of striated muscle (HP:0009728)1.85636093
147Recurrent viral infections (HP:0004429)1.84972822
148Abnormality of the columella (HP:0009929)1.83918142
149Abnormal sex determination (HP:0012244)1.83688317
150Sex reversal (HP:0012245)1.83688317
151Elbow flexion contracture (HP:0002987)1.83592125
152Increased IgE level (HP:0003212)1.83004272
153Prominent metopic ridge (HP:0005487)1.82608665
154Clubbing of toes (HP:0100760)1.81976742
155Distal upper limb amyotrophy (HP:0007149)1.81745573
156Upper limb amyotrophy (HP:0009129)1.81745573
157Microretrognathia (HP:0000308)1.81702836
158Severe combined immunodeficiency (HP:0004430)1.81229259
159Abnormality of the salivary glands (HP:0010286)1.80907439
160Ureteral stenosis (HP:0000071)1.80887396
161Myopathic facies (HP:0002058)1.79982124
162J-shaped sella turcica (HP:0002680)1.79630332
163Short clavicles (HP:0000894)1.79448117
164Leukopenia (HP:0001882)1.79176137
165Impulsivity (HP:0100710)1.78912605
166Trismus (HP:0000211)1.78481506
167Lymphopenia (HP:0001888)1.77407251
168Poikiloderma (HP:0001029)1.76543331
169Hypoplasia of the radius (HP:0002984)1.75884369
170Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74606854
171Absent epiphyses (HP:0010577)1.74606854
172Absent hand (HP:0004050)1.74379588
173Abnormality of cells of the lymphoid lineage (HP:0012140)1.73960917
174Distal lower limb amyotrophy (HP:0008944)1.72911461
175Tracheoesophageal fistula (HP:0002575)1.71899749
176Aplasia/hypoplasia of the humerus (HP:0006507)1.70680904
177Abnormality of iron homeostasis (HP:0011031)1.70397966
178Bone pain (HP:0002653)1.69826804
179Thrombocytosis (HP:0001894)1.69703474
180Aplasia/Hypoplasia of the clavicles (HP:0006710)1.69040555
181Bowed forearm bones (HP:0003956)1.67598382
182Bowing of the arm (HP:0006488)1.67598382
183Difficulty climbing stairs (HP:0003551)1.67101328
184Flat occiput (HP:0005469)1.66757620
185Fasciculations (HP:0002380)1.66606728
186Abnormality of the gallbladder (HP:0005264)1.66314266
187Gastrointestinal inflammation (HP:0004386)1.66149457
188Rectovaginal fistula (HP:0000143)1.65883532
189Rectal fistula (HP:0100590)1.65883532
190Emphysema (HP:0002097)1.62683710
191Flattened epiphyses (HP:0003071)1.61219521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.58980023
2MAP3K63.72070035
3IRAK33.68774150
4SMG13.34255545
5TESK23.27484998
6TRIB33.26948653
7STK102.99982572
8MAP2K62.99527306
9MAP2K32.80987434
10PRPF4B2.67577095
11EEF2K2.57962217
12STK162.43654955
13WEE12.33641733
14MAP3K102.30460039
15SIK12.26288778
16ZAP702.25282480
17RPS6KB22.16445410
18TAOK22.09251321
19EPHA21.89287302
20NME21.87739554
21TSSK61.79183369
22NME11.75296282
23TLK11.74701915
24MAP2K21.74077059
25KDR1.59420265
26TBK11.54394944
27NEK21.49066443
28BCKDK1.48075331
29EIF2AK11.47481757
30UHMK11.44318280
31SRPK11.44256959
32MAP4K11.44189670
33VRK11.40911929
34TAOK11.38047669
35SCYL21.36616509
36PIM21.34962962
37TESK11.32281720
38PASK1.30913447
39PLK11.28579596
40ABL21.28100952
41CLK11.27639759
42ICK1.27517691
43ERN11.24974019
44IRAK41.24542366
45MAP3K31.23343419
46TTK1.21662649
47MAP3K111.20628384
48CHEK21.17413853
49MAP3K131.16052465
50CDC71.15611510
51MAP3K141.13898430
52EIF2AK31.13801976
53PNCK1.13695076
54MKNK11.13383686
55ATR1.11653992
56DYRK31.11152770
57MAPKAPK31.09200775
58VRK21.07008364
59AURKA1.06247306
60CDK71.05218121
61PRKD21.04973338
62ARAF1.03362499
63RPS6KA40.96415933
64PAK20.94226383
65PRKD30.91745896
66BRD40.91673326
67BLK0.90676080
68PIM10.89898345
69AURKB0.89417267
70MAP3K50.88578202
71RPS6KC10.87636205
72RPS6KL10.87636205
73MST40.85559818
74MAP3K80.83365347
75CDC42BPA0.80860077
76LRRK20.80309019
77DYRK20.80212343
78PAK10.78768806
79TTN0.77315163
80MAP3K10.76724265
81MATK0.76440369
82CCNB10.76257567
83IKBKB0.74990445
84KIT0.73953948
85CDK11A0.73758356
86EIF2AK20.72622249
87RPS6KA20.72304413
88PTK60.71880442
89MAPK110.69396817
90RIPK40.69176192
91CDK150.68650515
92CHEK10.68562184
93RPS6KA60.67130409
94CDK180.66796798
95CHUK0.64040310
96SIK30.64026693
97BTK0.63740103
98GRK60.63572966
99IKBKE0.63343263
100MKNK20.62286795
101MAPK40.62112382
102EPHB20.61237944
103TGFBR10.61227330
104CAMK1D0.59123697
105PKN20.58886516
106BMX0.58717509
107CDK20.58597877
108DDR20.57188442
109RIPK10.56763301
110CDK120.56636684
111BRAF0.56391083
112CDK40.54111616
113PDPK10.53636690
114CDK140.52489417
115LIMK10.51703164
116LCK0.51363257
117AKT20.50680010
118HIPK20.50328246
119PAK40.49668204
120TYK20.48713538
121BRSK20.48472469
122RPS6KA50.48139794
123ILK0.47771386
124CAMK10.47317263
125MOS0.46680052
126FGFR40.46291413
127PLK40.46221496
128MTOR0.46131796
129CSNK1G30.46083202
130MAP2K40.44120129
131CSF1R0.43547507
132MARK20.43479028
133MARK30.43207548
134PAK60.43030200
135MAPK150.42701166
136CDK190.42660495
137TNK20.41297686
138SIK20.41288577
139JAK30.40815679
140ATM0.40480227
141STK40.40427491
142CDK60.39910231
143SYK0.39616083
144RPS6KA10.39337761
145IRAK20.38421710
146CSNK1A1L0.37994747
147PLK30.37890703
148MAPKAPK20.36630961
149CDK10.36346456
150PRKCI0.36234511
151DAPK10.35476376
152CSNK2A20.34319824
153ALK0.34233840
154DAPK30.34029382

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.74417811
2Ribosome_Homo sapiens_hsa030103.64795934
3RNA polymerase_Homo sapiens_hsa030203.62242928
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57961844
5Mismatch repair_Homo sapiens_hsa034303.53722589
6Spliceosome_Homo sapiens_hsa030403.47461347
7DNA replication_Homo sapiens_hsa030303.39602320
8Other glycan degradation_Homo sapiens_hsa005113.31777810
9RNA transport_Homo sapiens_hsa030132.93297834
10Sulfur relay system_Homo sapiens_hsa041222.87354784
11Fanconi anemia pathway_Homo sapiens_hsa034602.52060546
12Base excision repair_Homo sapiens_hsa034102.48596496
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.44935865
14Nucleotide excision repair_Homo sapiens_hsa034202.38708060
15Basal transcription factors_Homo sapiens_hsa030222.37520629
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.37188403
17One carbon pool by folate_Homo sapiens_hsa006702.27601854
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14486021
19Lysosome_Homo sapiens_hsa041422.07905399
20Bladder cancer_Homo sapiens_hsa052192.05056009
21Pyrimidine metabolism_Homo sapiens_hsa002402.04349446
22Asthma_Homo sapiens_hsa053101.96388981
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90471922
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88685828
25Cell cycle_Homo sapiens_hsa041101.74048005
26Fructose and mannose metabolism_Homo sapiens_hsa000511.71545236
27Homologous recombination_Homo sapiens_hsa034401.69256690
28Primary immunodeficiency_Homo sapiens_hsa053401.67275698
29Osteoclast differentiation_Homo sapiens_hsa043801.66452030
30Leishmaniasis_Homo sapiens_hsa051401.65730118
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60870970
32mRNA surveillance pathway_Homo sapiens_hsa030151.53422542
33Shigellosis_Homo sapiens_hsa051311.52261138
34RNA degradation_Homo sapiens_hsa030181.51775233
35Epstein-Barr virus infection_Homo sapiens_hsa051691.48695174
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36730544
37p53 signaling pathway_Homo sapiens_hsa041151.34510530
38Protein export_Homo sapiens_hsa030601.33297873
39Vitamin B6 metabolism_Homo sapiens_hsa007501.29799020
40Galactose metabolism_Homo sapiens_hsa000521.25151151
41Tuberculosis_Homo sapiens_hsa051521.23924506
42Toxoplasmosis_Homo sapiens_hsa051451.21639527
43Hepatitis C_Homo sapiens_hsa051601.21088084
44Non-homologous end-joining_Homo sapiens_hsa034501.20160443
45TNF signaling pathway_Homo sapiens_hsa046681.11189865
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.11016714
47Notch signaling pathway_Homo sapiens_hsa043301.07982170
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.02852737
49Allograft rejection_Homo sapiens_hsa053301.02475508
50Pertussis_Homo sapiens_hsa051331.01021148
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00734652
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00139462
53Prion diseases_Homo sapiens_hsa050200.98145101
54Folate biosynthesis_Homo sapiens_hsa007900.95919852
55Pancreatic cancer_Homo sapiens_hsa052120.95044120
56Non-small cell lung cancer_Homo sapiens_hsa052230.94682946
57Systemic lupus erythematosus_Homo sapiens_hsa053220.93181913
58Rheumatoid arthritis_Homo sapiens_hsa053230.92891439
59Hematopoietic cell lineage_Homo sapiens_hsa046400.92145412
60Herpes simplex infection_Homo sapiens_hsa051680.91604999
61Purine metabolism_Homo sapiens_hsa002300.90285635
62Viral myocarditis_Homo sapiens_hsa054160.89384538
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86688038
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86629332
65Biosynthesis of amino acids_Homo sapiens_hsa012300.81714809
66Vibrio cholerae infection_Homo sapiens_hsa051100.81136476
67Viral carcinogenesis_Homo sapiens_hsa052030.79655874
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79596406
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.79313627
70Autoimmune thyroid disease_Homo sapiens_hsa053200.79017626
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78068228
72Staphylococcus aureus infection_Homo sapiens_hsa051500.77726073
73HTLV-I infection_Homo sapiens_hsa051660.77171759
74Pentose phosphate pathway_Homo sapiens_hsa000300.75376526
75Antigen processing and presentation_Homo sapiens_hsa046120.75316841
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74953623
77T cell receptor signaling pathway_Homo sapiens_hsa046600.72358386
78Phagosome_Homo sapiens_hsa041450.71220378
79Basal cell carcinoma_Homo sapiens_hsa052170.70033641
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65265676
81Graft-versus-host disease_Homo sapiens_hsa053320.64636859
82Malaria_Homo sapiens_hsa051440.64342051
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64146635
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.64015211
85Glutathione metabolism_Homo sapiens_hsa004800.61700113
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59836588
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.58444856
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58135445
89N-Glycan biosynthesis_Homo sapiens_hsa005100.57631204
90Apoptosis_Homo sapiens_hsa042100.56312126
91Linoleic acid metabolism_Homo sapiens_hsa005910.55611329
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55334284
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55320041
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.54540784
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53764589
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52955855
97Huntingtons disease_Homo sapiens_hsa050160.52663725
98Sphingolipid metabolism_Homo sapiens_hsa006000.52323294
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52180593
100Measles_Homo sapiens_hsa051620.51732430
101mTOR signaling pathway_Homo sapiens_hsa041500.48038602
102Legionellosis_Homo sapiens_hsa051340.47271228
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46293808
104Colorectal cancer_Homo sapiens_hsa052100.45286409
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43044513
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42747943
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.42738149
108Alcoholism_Homo sapiens_hsa050340.42376980
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.42004212
110Hippo signaling pathway_Homo sapiens_hsa043900.41366218
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40689957
112VEGF signaling pathway_Homo sapiens_hsa043700.39380955
113Small cell lung cancer_Homo sapiens_hsa052220.37764127
114Hedgehog signaling pathway_Homo sapiens_hsa043400.37462453
115Acute myeloid leukemia_Homo sapiens_hsa052210.36779203
116Regulation of autophagy_Homo sapiens_hsa041400.34846283
117Parkinsons disease_Homo sapiens_hsa050120.34543414
118Chronic myeloid leukemia_Homo sapiens_hsa052200.34319030
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34186132
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34094183
121Influenza A_Homo sapiens_hsa051640.33116702
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32550347
123MicroRNAs in cancer_Homo sapiens_hsa052060.32122062
124B cell receptor signaling pathway_Homo sapiens_hsa046620.31871786
125Pathways in cancer_Homo sapiens_hsa052000.31436210
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31169446
127Salmonella infection_Homo sapiens_hsa051320.31100385
128Hepatitis B_Homo sapiens_hsa051610.30333594
129Ether lipid metabolism_Homo sapiens_hsa005650.29560519
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28010784
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26296960
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24434791
133Oocyte meiosis_Homo sapiens_hsa041140.24253984
134Wnt signaling pathway_Homo sapiens_hsa043100.23478239
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.22957728
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22763575
137Arachidonic acid metabolism_Homo sapiens_hsa005900.22654856
138Prolactin signaling pathway_Homo sapiens_hsa049170.22514505
139Metabolic pathways_Homo sapiens_hsa011000.22452302
140Oxidative phosphorylation_Homo sapiens_hsa001900.21518548
141Carbon metabolism_Homo sapiens_hsa012000.20199488
142Endocytosis_Homo sapiens_hsa041440.17964422
143Lysine degradation_Homo sapiens_hsa003100.15475699
144Sulfur metabolism_Homo sapiens_hsa009200.15324065

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