ADAMTS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)8.83989449
2axon extension involved in axon guidance (GO:0048846)8.83989449
3lung epithelium development (GO:0060428)7.57872781
4epithelial cell fate commitment (GO:0072148)7.57236292
5endocardial cushion morphogenesis (GO:0003203)6.27460901
6chondrocyte proliferation (GO:0035988)6.18596876
7epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.96004645
8cell migration involved in heart development (GO:0060973)5.89180822
9lens fiber cell development (GO:0070307)5.82000706
10midgut development (GO:0007494)5.77444097
11heart valve formation (GO:0003188)5.76612345
12planar cell polarity pathway involved in neural tube closure (GO:0090179)5.54938241
13paraxial mesoderm development (GO:0048339)5.42872644
14negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.42420346
15mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.33558394
16Notch signaling involved in heart development (GO:0061314)5.32074640
17neuronal stem cell maintenance (GO:0097150)5.30263780
18venous blood vessel morphogenesis (GO:0048845)5.28742628
19atrioventricular valve morphogenesis (GO:0003181)5.24284483
20epithelial cell differentiation involved in prostate gland development (GO:0060742)5.22820137
21central nervous system myelination (GO:0022010)5.16820274
22axon ensheathment in central nervous system (GO:0032291)5.16820274
23negative regulation of oligodendrocyte differentiation (GO:0048715)5.15051690
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.14845355
25coronary vasculature morphogenesis (GO:0060977)5.07396954
26regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.94245421
27ventricular trabecula myocardium morphogenesis (GO:0003222)4.93162060
28mesenchyme morphogenesis (GO:0072132)4.83899319
29negative regulation of epidermis development (GO:0045683)4.79912918
30collecting duct development (GO:0072044)4.76072755
31regulation of somitogenesis (GO:0014807)4.61078082
32somite development (GO:0061053)4.50303867
33exocrine pancreas development (GO:0031017)4.45028240
34negative regulation of glial cell proliferation (GO:0060253)4.43287946
35convergent extension (GO:0060026)4.40825874
36regulation of extracellular matrix organization (GO:1903053)4.40737522
37regulation of endothelial cell chemotaxis (GO:2001026)4.38579989
38cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.33837670
39embryonic camera-type eye development (GO:0031076)4.32911661
40renal system development (GO:0072001)4.27455118
41heterochromatin organization (GO:0070828)4.25454625
42collagen fibril organization (GO:0030199)4.17649509
43negative regulation of astrocyte differentiation (GO:0048712)4.16948747
44cardiac muscle cell proliferation (GO:0060038)4.10888683
45regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.04027526
46endodermal cell differentiation (GO:0035987)4.03197634
47positive regulation of astrocyte differentiation (GO:0048711)4.02766413
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.01652779
49dorsal/ventral neural tube patterning (GO:0021904)3.99487520
50positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.99076934
51protein heterotrimerization (GO:0070208)3.98071514
52heart trabecula morphogenesis (GO:0061384)3.96710659
53bone trabecula formation (GO:0060346)3.95236881
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.94250468
55thalamus development (GO:0021794)3.87895072
56striated muscle cell proliferation (GO:0014855)3.87230120
57regulation of establishment of planar polarity (GO:0090175)3.76832527
58negative regulation of glial cell differentiation (GO:0045686)3.74296412
59basement membrane organization (GO:0071711)3.72339966
60regulation of astrocyte differentiation (GO:0048710)3.67375643
61apoptotic process involved in morphogenesis (GO:0060561)3.66630828
62positive regulation of BMP signaling pathway (GO:0030513)3.63952760
63muscle cell fate commitment (GO:0042693)3.61910768
64embryonic foregut morphogenesis (GO:0048617)3.61060035
65retina vasculature morphogenesis in camera-type eye (GO:0061299)3.58902691
66lymphangiogenesis (GO:0001946)3.54820672
67atrial septum morphogenesis (GO:0060413)3.51851702
68G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.48772617
69cardiac ventricle formation (GO:0003211)3.47601939
70endothelial cell morphogenesis (GO:0001886)3.47298184
71nephron tubule development (GO:0072080)3.46432465
72negative regulation of myotube differentiation (GO:0010832)3.46316903
73type B pancreatic cell development (GO:0003323)3.42856908
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39879888
75myoblast migration (GO:0051451)3.39735696
76embryonic viscerocranium morphogenesis (GO:0048703)3.38953011
77semaphorin-plexin signaling pathway (GO:0071526)3.37918781
78non-canonical Wnt signaling pathway (GO:0035567)3.37913488
79trabecula morphogenesis (GO:0061383)3.37616489
80outer ear morphogenesis (GO:0042473)3.35629457
81cell surface receptor signaling pathway involved in heart development (GO:0061311)3.35201933
82cardiac left ventricle morphogenesis (GO:0003214)3.34501659
83muscle cell proliferation (GO:0033002)3.33832878
84chaperone-mediated protein transport (GO:0072321)3.32179052
85collagen metabolic process (GO:0032963)3.30699510
86inner ear receptor cell differentiation (GO:0060113)3.30277179
87cochlea morphogenesis (GO:0090103)3.29796638
88lens morphogenesis in camera-type eye (GO:0002089)3.29595687
89regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.28464101
90apoptotic process involved in development (GO:1902742)3.27702332
91cardiac chamber formation (GO:0003207)3.23598344
92astrocyte differentiation (GO:0048708)3.22427586
93cell migration involved in sprouting angiogenesis (GO:0002042)3.21704664
94collagen catabolic process (GO:0030574)3.20888196
95endoderm development (GO:0007492)3.20315705
96left/right axis specification (GO:0070986)3.17536477
97forebrain morphogenesis (GO:0048853)3.17449417
98negative regulation of axon guidance (GO:1902668)3.16871069
99positive regulation of keratinocyte differentiation (GO:0045618)3.14147763
100positive regulation of epithelial to mesenchymal transition (GO:0010718)3.13393865
101negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.12505213
102vascular endothelial growth factor signaling pathway (GO:0038084)3.11582879
103multicellular organismal macromolecule metabolic process (GO:0044259)3.09719285
104response to follicle-stimulating hormone (GO:0032354)3.09672336
105notochord development (GO:0030903)3.07670455
106* negative regulation of chondrocyte differentiation (GO:0032331)3.05597515
107protein retention in ER lumen (GO:0006621)3.04917560
108chondrocyte development (GO:0002063)3.03814080
109cellular response to cholesterol (GO:0071397)3.03536166
110establishment of apical/basal cell polarity (GO:0035089)3.02665654
111vasculogenesis (GO:0001570)3.02383183
112adherens junction assembly (GO:0034333)2.98906504
113renal tubule development (GO:0061326)2.97733497
114positive regulation of extracellular matrix organization (GO:1903055)2.97019877
115metanephric mesenchyme development (GO:0072075)2.96878143
116negative regulation of catenin import into nucleus (GO:0035414)2.96153475
117blood vessel maturation (GO:0001955)2.95957432
118hippo signaling (GO:0035329)2.95301723
119ventricular septum morphogenesis (GO:0060412)2.95168322
120dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.94638505
121lung-associated mesenchyme development (GO:0060484)2.94222205
122negative regulation of blood vessel endothelial cell migration (GO:0043537)2.93308575
123multicellular organismal catabolic process (GO:0044243)2.92974206
124endothelium development (GO:0003158)2.92270101
125muscle cell migration (GO:0014812)2.91740167
126kidney mesenchyme development (GO:0072074)2.89684483
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88972299
128negative regulation of cell size (GO:0045792)2.87794243
129multicellular organismal metabolic process (GO:0044236)2.87754862
130axon extension (GO:0048675)2.86183545
131wound healing, spreading of epidermal cells (GO:0035313)2.86151737
132negative regulation of gliogenesis (GO:0014014)2.86014432
133establishment of tissue polarity (GO:0007164)2.85856033
134establishment of planar polarity (GO:0001736)2.85856033
135cardiac epithelial to mesenchymal transition (GO:0060317)2.84674789
136mammary gland epithelial cell differentiation (GO:0060644)2.83939411
137camera-type eye morphogenesis (GO:0048593)2.83731061
138extracellular matrix disassembly (GO:0022617)2.83727164
139establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.83444660
140neural tube development (GO:0021915)2.83306753
141skin morphogenesis (GO:0043589)2.82514188
142positive regulation of neuroblast proliferation (GO:0002052)2.81860730
143Notch receptor processing (GO:0007220)2.81853474
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81416298
145negative regulation of embryonic development (GO:0045992)2.81389995
146heart valve morphogenesis (GO:0003179)2.81310424
147respiratory tube development (GO:0030323)2.80379566
148regulation of cell fate specification (GO:0042659)2.79731233
149branching involved in salivary gland morphogenesis (GO:0060445)2.79230858
150nephron epithelium development (GO:0072009)2.79194612
151establishment or maintenance of monopolar cell polarity (GO:0061339)2.78410342
152establishment of monopolar cell polarity (GO:0061162)2.78410342
153glandular epithelial cell development (GO:0002068)2.77224153
154cell migration in hindbrain (GO:0021535)2.76518003
155digestive tract morphogenesis (GO:0048546)2.76348750
156establishment or maintenance of bipolar cell polarity (GO:0061245)2.76281775
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.76281775
158regulation of catenin import into nucleus (GO:0035412)2.76229180
159negative regulation of cell fate specification (GO:0009996)2.67977236
160substrate-dependent cell migration (GO:0006929)2.67681132
161ganglion development (GO:0061548)2.66962251
162artery development (GO:0060840)2.63709306
163cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61766751
164substrate adhesion-dependent cell spreading (GO:0034446)2.61113290
165positive regulation of SMAD protein import into nucleus (GO:0060391)2.58797900
166extracellular fibril organization (GO:0043206)2.58451484
167lymph vessel development (GO:0001945)2.57203188
168regulation of axon extension involved in axon guidance (GO:0048841)2.55842356
169tooth mineralization (GO:0034505)2.54595251
170negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.54380663
171focal adhesion assembly (GO:0048041)2.53476720
172cell-substrate adherens junction assembly (GO:0007045)2.53476720
173lateral sprouting from an epithelium (GO:0060601)2.52746595
174glomerular basement membrane development (GO:0032836)2.52649237
175cardiac myofibril assembly (GO:0055003)2.51954349
176regulation of posttranscriptional gene silencing (GO:0060147)2.51566310
177regulation of gene silencing by miRNA (GO:0060964)2.51566310
178regulation of gene silencing by RNA (GO:0060966)2.51566310
179sequestering of extracellular ligand from receptor (GO:0035581)2.50531927
180cell proliferation involved in metanephros development (GO:0072203)2.50495607
181heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.49787314
182positive regulation of catenin import into nucleus (GO:0035413)2.49765232
183negative regulation of axon extension involved in axon guidance (GO:0048843)2.49049299
184epithelial cell-cell adhesion (GO:0090136)2.47459644
185vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47282862
186blood vessel endothelial cell migration (GO:0043534)2.47264762
187cell-substrate junction assembly (GO:0007044)2.46758425
188eye morphogenesis (GO:0048592)2.46233706
189negative chemotaxis (GO:0050919)2.45623018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.57271281
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.14364795
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45720992
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.06500228
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.06306883
6EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.93088461
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92354876
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59790353
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48168062
10TP53_20018659_ChIP-ChIP_R1E_Mouse2.46185484
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.42664474
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17352161
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17172798
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17172798
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16546153
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.13186388
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11515602
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.06402778
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06254519
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.05769298
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.05557693
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02931040
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97765005
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96887824
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95555090
26EZH2_22144423_ChIP-Seq_EOC_Human1.87843862
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86496398
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85406110
29CLOCK_20551151_ChIP-Seq_293T_Human1.84977190
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81243414
31* LXR_22158963_ChIP-Seq_LIVER_Mouse1.78362044
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76420772
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74980749
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71128641
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.70539465
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69198381
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67855176
38ZNF263_19887448_ChIP-Seq_K562_Human1.63993520
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.61627828
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61208570
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60064583
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59210426
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.58754700
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.57694197
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57058047
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55865155
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54839384
48TP53_22127205_ChIP-Seq_IMR90_Human1.54631883
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54090046
50* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51316788
51LXR_22292898_ChIP-Seq_THP-1_Human1.50515590
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49975016
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.48978773
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47174026
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45726225
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.44969723
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44894440
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44391338
59KDM2B_26808549_Chip-Seq_K562_Human1.43992086
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41366802
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.39942353
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39271306
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38911149
64CTCF_27219007_Chip-Seq_Bcells_Human1.37819230
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34107519
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33963625
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33495826
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32714257
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30738340
70* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30384893
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27160430
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25721954
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.25599175
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.25567697
75* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21859433
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21375372
77* RNF2_27304074_Chip-Seq_ESCs_Mouse1.21321766
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21091824
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.20846459
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20602474
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.20297189
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.20297189
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18538400
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18324353
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17358878
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17189270
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15601608
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.15488905
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13922325
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11997876
91RACK7_27058665_Chip-Seq_MCF-7_Human1.11511240
92SA1_22415368_ChIP-Seq_MEFs_Mouse1.11108069
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.10677192
94SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09580176
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09475396
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.07349698
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.06880508
98VDR_21846776_ChIP-Seq_THP-1_Human1.06671306
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03580795
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02971293
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02565112
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02556376
103DROSHA_22980978_ChIP-Seq_HELA_Human1.02316601
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02197192
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02134204
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01869445
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.00600373
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00145332
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98856269
110* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98573866
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98387908
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98372104
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98201181
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97347410
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96659937
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95921811
117BRD4_25478319_ChIP-Seq_HGPS_Human0.95633544
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95122466
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.95086200
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95076656
121JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94829877
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94537952
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94433400
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93225433
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.92983593
126KDM2B_26808549_Chip-Seq_DND41_Human0.92139635
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91647723
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90738718
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90738718
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90738718
131AR_21909140_ChIP-Seq_LNCAP_Human0.90729798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.94611230
2MP0010030_abnormal_orbit_morphology6.22459604
3MP0009780_abnormal_chondrocyte_physiolo4.76981070
4MP0003880_abnormal_central_pattern3.34194959
5MP0005423_abnormal_somatic_nervous3.06986326
6MP0005257_abnormal_intraocular_pressure3.03484445
7MP0002249_abnormal_larynx_morphology2.68588388
8MP0004272_abnormal_basement_membrane2.41303445
9MP0003283_abnormal_digestive_organ2.37618521
10MP0003705_abnormal_hypodermis_morpholog2.35834115
11MP0002102_abnormal_ear_morphology2.30189828
12MP0001958_emphysema2.24821725
13MP0000049_abnormal_middle_ear2.22875349
14MP0004858_abnormal_nervous_system2.14926283
15MP0008438_abnormal_cutaneous_collagen2.13982891
16MP0003566_abnormal_cell_adhesion2.10273656
17MP0002254_reproductive_system_inflammat2.08497824
18MP0002089_abnormal_postnatal_growth/wei2.05103292
19MP0003115_abnormal_respiratory_system2.02787590
20MP0009384_cardiac_valve_regurgitation2.00103694
21MP0002282_abnormal_trachea_morphology1.89992358
22MP0001879_abnormal_lymphatic_vessel1.84992071
23MP0001849_ear_inflammation1.81988251
24MP0000428_abnormal_craniofacial_morphol1.75877546
25MP0009053_abnormal_anal_canal1.75457181
26MP0004381_abnormal_hair_follicle1.74346942
27MP0003941_abnormal_skin_development1.73963884
28MP0004133_heterotaxia1.68422833
29MP0003279_aneurysm1.54368455
30MP0010368_abnormal_lymphatic_system1.53999186
31MP0002139_abnormal_hepatobiliary_system1.53081339
32MP0000762_abnormal_tongue_morphology1.51170523
33MP0002751_abnormal_autonomic_nervous1.45720834
34MP0002653_abnormal_ependyma_morphology1.44274399
35MP0004134_abnormal_chest_morphology1.42587449
36MP0002837_dystrophic_cardiac_calcinosis1.39678052
37MP0005508_abnormal_skeleton_morphology1.38707599
38MP0000013_abnormal_adipose_tissue1.38286267
39MP0005503_abnormal_tendon_morphology1.36742387
40MP0001293_anophthalmia1.34380658
41MP0005360_urolithiasis1.33004068
42MP0009250_abnormal_appendicular_skeleto1.30659332
43MP0005085_abnormal_gallbladder_physiolo1.28744757
44MP0000467_abnormal_esophagus_morphology1.27313194
45MP0005623_abnormal_meninges_morphology1.22041890
46MP0001542_abnormal_bone_strength1.21816633
47MP0001299_abnormal_eye_distance/1.20962186
48MP0002932_abnormal_joint_morphology1.20651883
49MP0002234_abnormal_pharynx_morphology1.20535096
50MP0003938_abnormal_ear_development1.17893799
51MP0005275_abnormal_skin_tensile1.16484114
52MP0006276_abnormal_autonomic_nervous1.15184316
53MP0003755_abnormal_palate_morphology1.14712473
54MP0003937_abnormal_limbs/digits/tail_de1.12824445
55MP0002295_abnormal_pulmonary_circulatio1.12695018
56MP0000163_abnormal_cartilage_morphology1.11111724
57MP0002092_abnormal_eye_morphology1.10407114
58MP0000733_abnormal_muscle_development1.10157677
59MP0003119_abnormal_digestive_system1.08530682
60MP0004084_abnormal_cardiac_muscle1.08351896
61MP0000751_myopathy1.08101488
62MP0003935_abnormal_craniofacial_develop1.07883401
63MP0004233_abnormal_muscle_weight1.06184247
64MP0000647_abnormal_sebaceous_gland1.05374317
65MP0003385_abnormal_body_wall1.05298371
66MP0005365_abnormal_bile_salt1.04557324
67MP0001915_intracranial_hemorrhage1.04042465
68MP0005248_abnormal_Harderian_gland1.03965044
69MP0000537_abnormal_urethra_morphology1.02338465
70MP0005595_abnormal_vascular_smooth1.01233648
71MP0008961_abnormal_basal_metabolism1.01179776
72MP0000569_abnormal_digit_pigmentation1.01139505
73MP0000003_abnormal_adipose_tissue1.01089980
74MP0006138_congestive_heart_failure1.00058878
75MP0005220_abnormal_exocrine_pancreas0.98799668
76MP0004145_abnormal_muscle_electrophysio0.97712409
77MP0002114_abnormal_axial_skeleton0.96215141
78MP0005197_abnormal_uvea_morphology0.95423165
79MP0003122_maternal_imprinting0.94847524
80MP0002896_abnormal_bone_mineralization0.93838650
81MP0003890_abnormal_embryonic-extraembry0.93035876
82MP0003942_abnormal_urinary_system0.92284072
83MP0002060_abnormal_skin_morphology0.91108917
84MP0008932_abnormal_embryonic_tissue0.90450455
85MP0002233_abnormal_nose_morphology0.90413768
86MP0000383_abnormal_hair_follicle0.88632811
87MP0003091_abnormal_cell_migration0.88502422
88MP0005409_darkened_coat_color0.88134956
89MP0001348_abnormal_lacrimal_gland0.85929962
90MP0010630_abnormal_cardiac_muscle0.85417404
91MP0001286_abnormal_eye_development0.84913170
92MP0000462_abnormal_digestive_system0.84878746
93MP0000759_abnormal_skeletal_muscle0.84563430
94MP0002116_abnormal_craniofacial_bone0.84529613
95MP0009672_abnormal_birth_weight0.82592393
96MP0005076_abnormal_cell_differentiation0.80414692
97MP0003137_abnormal_impulse_conducting0.79543812
98MP0002127_abnormal_cardiovascular_syste0.78725297
99MP0002108_abnormal_muscle_morphology0.78070713
100MP0001243_abnormal_dermal_layer0.77464779
101MP0005023_abnormal_wound_healing0.76418254
102MP0001730_embryonic_growth_arrest0.75605586
103MP0002081_perinatal_lethality0.75200859
104MP0002933_joint_inflammation0.74880184
105MP0004859_abnormal_synaptic_plasticity0.74747041
106MP0000534_abnormal_ureter_morphology0.74742765
107MP0003453_abnormal_keratinocyte_physiol0.74351900
108MP0000750_abnormal_muscle_regeneration0.74331164
109MP0000266_abnormal_heart_morphology0.73994944
110MP0000579_abnormal_nail_morphology0.72977713
111MP0002111_abnormal_tail_morphology0.72890670
112MP0002925_abnormal_cardiovascular_devel0.72061341
113MP0008789_abnormal_olfactory_epithelium0.72049865
114MP0005193_abnormal_anterior_eye0.71869780
115MP0000778_abnormal_nervous_system0.71430402
116MP0001175_abnormal_lung_morphology0.70827737
117MP0002084_abnormal_developmental_patter0.70781545
118MP0003861_abnormal_nervous_system0.70538466
119MP0005171_absent_coat_pigmentation0.70329106
120MP0004087_abnormal_muscle_fiber0.70209236
121MP0000749_muscle_degeneration0.70183187
122MP0003984_embryonic_growth_retardation0.70096529
123MP0005377_hearing/vestibular/ear_phenot0.70018711
124MP0003878_abnormal_ear_physiology0.70018711
125MP0002088_abnormal_embryonic_growth/wei0.69652079
126MP0002085_abnormal_embryonic_tissue0.69108489
127MP0003252_abnormal_bile_duct0.67940161
128MP0003567_abnormal_fetal_cardiomyocyte0.67732703
129MP0000432_abnormal_head_morphology0.66779652
130MP0002128_abnormal_blood_circulation0.63085721
131MP0004197_abnormal_fetal_growth/weight/0.62808780
132MP0000767_abnormal_smooth_muscle0.62432813
133MP0006054_spinal_hemorrhage0.61269548
134MP0001614_abnormal_blood_vessel0.61173749
135MP0000377_abnormal_hair_follicle0.60335690
136MP0002697_abnormal_eye_size0.59825323

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)6.39393727
2Protrusio acetabuli (HP:0003179)6.07076615
3Coronal craniosynostosis (HP:0004440)4.84577744
4Partial duplication of thumb phalanx (HP:0009944)4.26930834
5Aplasia involving bones of the extremities (HP:0009825)4.13522081
6Aplasia involving bones of the upper limbs (HP:0009823)4.13522081
7Aplasia of the phalanges of the hand (HP:0009802)4.13522081
8Partial duplication of the phalanx of hand (HP:0009999)4.01947427
9Alacrima (HP:0000522)3.91037683
10Heterotopia (HP:0002282)3.89676161
11Infantile muscular hypotonia (HP:0008947)3.80490884
12Adactyly (HP:0009776)3.71924127
13Neonatal death (HP:0003811)3.68013560
14Bladder diverticulum (HP:0000015)3.53995350
15Skull defect (HP:0001362)3.53730067
16Abnormality of dentin (HP:0010299)3.48278772
17Soft skin (HP:0000977)3.43622257
18Abnormality of the right ventricle (HP:0001707)3.36683818
19Aplasia cutis congenita (HP:0001057)3.31617274
20Visceral angiomatosis (HP:0100761)3.26582607
21Vitreoretinal degeneration (HP:0000655)3.13527150
22Genu recurvatum (HP:0002816)3.11791331
23Atrophic scars (HP:0001075)3.08589779
24Megalencephaly (HP:0001355)3.04266947
25Decreased lacrimation (HP:0000633)3.02269638
26Thickened helices (HP:0000391)2.97949074
27Hemangiomatosis (HP:0007461)2.96747531
28Recurrent corneal erosions (HP:0000495)2.93224295
29Abnormality of the middle phalanges of the toes (HP:0010183)2.93204189
30Spinal rigidity (HP:0003306)2.91605596
31Wrist flexion contracture (HP:0001239)2.87406003
32Cervical subluxation (HP:0003308)2.86150669
33Camptodactyly of toe (HP:0001836)2.82153688
34Lymphangioma (HP:0100764)2.82016320
35Abnormality of the lumbar spine (HP:0100712)2.81892001
36Bowel diverticulosis (HP:0005222)2.76972757
37Fragile skin (HP:0001030)2.74939883
38Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.74294887
39Thin ribs (HP:0000883)2.73142406
40Esophageal varix (HP:0002040)2.70841588
41Abnormality of the costochondral junction (HP:0000919)2.70316894
42Joint contractures involving the joints of the feet (HP:0100492)2.68601398
43Flexion contracture of toe (HP:0005830)2.68601398
44Turricephaly (HP:0000262)2.66991168
45Abnormality of the salivary glands (HP:0010286)2.66485091
46Wide anterior fontanel (HP:0000260)2.65075582
47Blue sclerae (HP:0000592)2.61363128
48Aortic aneurysm (HP:0004942)2.61312578
49Bifid scrotum (HP:0000048)2.59242921
50Limited hip movement (HP:0008800)2.56605996
51Hallux valgus (HP:0001822)2.55613627
52Hypoplastic scapulae (HP:0000882)2.54919423
53Aplasia/Hypoplasia of the scapulae (HP:0006713)2.54919423
54Ectopia lentis (HP:0001083)2.53775765
55Biconcave vertebral bodies (HP:0004586)2.53388788
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.52110287
57Uterine leiomyosarcoma (HP:0002891)2.51665942
58Leiomyosarcoma (HP:0100243)2.51665942
59Absent hand (HP:0004050)2.50776767
60Ulnar bowing (HP:0003031)2.50475196
61Disproportionate tall stature (HP:0001519)2.49686958
62Xerostomia (HP:0000217)2.49401807
63Type 1 muscle fiber predominance (HP:0003803)2.48330140
64Deviation of the hallux (HP:0010051)2.48092998
65Duplication of thumb phalanx (HP:0009942)2.47210672
66Aortic dissection (HP:0002647)2.46166383
67Abnormality of incisor morphology (HP:0011063)2.45815183
68Nasolacrimal duct obstruction (HP:0000579)2.43933062
69Increased variability in muscle fiber diameter (HP:0003557)2.42728241
70Preaxial foot polydactyly (HP:0001841)2.42121719
71Aneurysm (HP:0002617)2.41962778
72Wormian bones (HP:0002645)2.41411698
73Joint laxity (HP:0001388)2.38232279
74Short 4th metacarpal (HP:0010044)2.38070899
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38070899
76Germ cell neoplasia (HP:0100728)2.37428879
77Broad long bones (HP:0005622)2.37182427
78Broad hallux (HP:0010055)2.36829235
79Mitral valve prolapse (HP:0001634)2.36400361
80Abnormality of the intervertebral disk (HP:0005108)2.35162144
81Hyperacusis (HP:0010780)2.33038398
82Conical tooth (HP:0000698)2.32524310
83Renal duplication (HP:0000075)2.29325844
84Striae distensae (HP:0001065)2.29323900
85Overfolded helix (HP:0000396)2.29104092
86Peritonitis (HP:0002586)2.27927557
87Broad toe (HP:0001837)2.27234954
88Hyperextensible skin (HP:0000974)2.24691156
89Osteoarthritis (HP:0002758)2.24144750
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23494928
91Mitral regurgitation (HP:0001653)2.23364595
92Abnormality of the calcaneus (HP:0008364)2.18360456
93Spondylolisthesis (HP:0003302)2.18229607
94Abnormality of the lacrimal duct (HP:0011481)2.18169316
95Hypoventilation (HP:0002791)2.18084683
96Cerebral aneurysm (HP:0004944)2.16890591
97Gonadal dysgenesis (HP:0000133)2.16290110
98Neoplasm of the heart (HP:0100544)2.15988469
99Deep venous thrombosis (HP:0002625)2.15583122
100Ankle contracture (HP:0006466)2.15555455
101Abnormally folded helix (HP:0008544)2.15456655
102Broad alveolar ridges (HP:0000187)2.14245139
103Dilatation of the ascending aorta (HP:0005111)2.13833417
104Limited elbow extension (HP:0001377)2.13361669
105Porencephaly (HP:0002132)2.11154859
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.09765814
107Mixed hearing impairment (HP:0000410)2.08194881
108Broad phalanx (HP:0006009)2.07670332
109Vertebral arch anomaly (HP:0008438)2.07426874
110Arterial tortuosity (HP:0005116)2.07046572
111Broad thumb (HP:0011304)2.05927388
112Renal cell carcinoma (HP:0005584)2.04257842
113Abnormality of the antihelix (HP:0009738)2.03473279
114Hip contracture (HP:0003273)2.02695088
115Bronchomalacia (HP:0002780)2.02510844
116Mildly elevated creatine phosphokinase (HP:0008180)2.02033561
117Broad finger (HP:0001500)2.00582384
118Broad phalanges of the hand (HP:0009768)1.99940146
119Premature rupture of membranes (HP:0001788)1.98778552
120Shallow orbits (HP:0000586)1.98771442
121Concave nail (HP:0001598)1.98627367
122Increased nuchal translucency (HP:0010880)1.98260134
123Morphological abnormality of the middle ear (HP:0008609)1.97094870
124Abnormality of the nasolacrimal system (HP:0000614)1.96996234
125Transitional cell carcinoma of the bladder (HP:0006740)1.96651371
126Tarsal synostosis (HP:0008368)1.96116515
127Abnormality of skeletal muscle fiber size (HP:0012084)1.95820654
128Vertebral clefting (HP:0008428)1.95582476
129Rhizomelia (HP:0008905)1.93783802
130Broad metatarsal (HP:0001783)1.93565188
131Calcaneovalgus deformity (HP:0001848)1.91052130
132Nonimmune hydrops fetalis (HP:0001790)1.90844664
133Inguinal hernia (HP:0000023)1.89640615
134Lumbar hyperlordosis (HP:0002938)1.89262523
135Arnold-Chiari malformation (HP:0002308)1.88724519
136Spinal canal stenosis (HP:0003416)1.88458038
137Vascular tortuosity (HP:0004948)1.88380439
138Follicular hyperkeratosis (HP:0007502)1.87500565
139Generalized amyotrophy (HP:0003700)1.86883133
140Overgrowth (HP:0001548)1.86870172
141Cutis marmorata (HP:0000965)1.86055059
142Aortic regurgitation (HP:0001659)1.85524348
143Ventricular tachycardia (HP:0004756)1.84723686
144Bladder neoplasm (HP:0009725)1.84659526
145Bladder carcinoma (HP:0002862)1.84659526
146Renovascular hypertension (HP:0100817)1.84589688
147Broad ribs (HP:0000885)1.84501167
148Synostosis of carpal bones (HP:0005048)1.84396733
149Split hand (HP:0001171)1.84323593
150Flat cornea (HP:0007720)1.83667522
151Aortic valve stenosis (HP:0001650)1.83103546
152Skin nodule (HP:0200036)1.82696616
153Round ear (HP:0100830)1.82644119
154Abnormality of the acetabulum (HP:0003170)1.79318994
155Broad palm (HP:0001169)1.79284334
156Abnormality of the 4th metacarpal (HP:0010012)1.78286976
157Abnormal delivery (HP:0001787)1.75716402
158Trigonocephaly (HP:0000243)1.75106362
159Deformed tarsal bones (HP:0008119)1.74395407
160Cutaneous syndactyly (HP:0012725)1.73990363
161Mild short stature (HP:0003502)1.73897220
162Overriding aorta (HP:0002623)1.72626524
163Venous insufficiency (HP:0005293)1.72487548
164Hypoplastic ischia (HP:0003175)1.72370793
165Cutaneous finger syndactyly (HP:0010554)1.71156777
166Breech presentation (HP:0001623)1.70661229
167Protruding ear (HP:0000411)1.69627295
168Abnormality of the ischium (HP:0003174)1.69224078
169Natal tooth (HP:0000695)1.68330179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.31398082
2FGFR34.56608872
3NTRK13.09203966
4FGFR12.75621728
5EIF2AK12.73644987
6TYRO32.58402474
7PDGFRA2.57592088
8FGFR22.55332445
9MELK2.52827609
10CDK82.47412240
11MAP3K102.37051799
12FGFR42.37022574
13EPHB22.30019552
14CDK122.22429842
15TAOK22.17633079
16TRIB32.07942173
17MYLK1.98785412
18TTN1.90259788
19PKN21.89660997
20BRSK11.86240299
21MAP3K71.84925071
22SMG11.84427922
23TGFBR11.75230210
24PAK41.73801460
25DDR21.70435310
26ICK1.69791248
27TIE11.66345996
28EPHB11.60863361
29BCKDK1.59593559
30MAP3K111.58762036
31TESK11.45840271
32ERN11.41104899
33BRD41.40752974
34SCYL21.40568559
35SIK11.39234258
36CDK91.37170847
37LIMK11.34519953
38DMPK1.30790576
39MET1.28371872
40PBK1.26075057
41PRKD31.20455538
42DYRK31.18907431
43FLT31.17637547
44UHMK11.17311181
45PTK61.15267567
46ERBB21.07811215
47MARK11.07166980
48ROCK21.06126516
49DYRK21.00750575
50ROCK10.99752364
51CDK40.99195264
52MOS0.96063695
53CDC42BPA0.93584065
54TLK10.91079579
55ACVR1B0.88696474
56CAMK1G0.88642759
57NEK20.88394503
58MARK20.86077585
59PRKCZ0.84387960
60MTOR0.83418831
61RPS6KA40.82352913
62SIK30.82167190
63PRKG20.80570712
64RPS6KC10.79453747
65RPS6KL10.79453747
66NEK90.79235490
67KSR10.78881848
68MAP3K60.78066658
69PTK2B0.76965127
70DYRK1B0.75883842
71EIF2AK30.73358067
72EEF2K0.73134534
73LATS10.72450804
74DAPK30.71770581
75INSRR0.69168883
76AKT20.66930195
77ERBB40.66609199
78LATS20.61813833
79MKNK10.61807141
80KDR0.60200766
81TAF10.59722395
82MUSK0.59011183
83CDK11A0.58962558
84RPS6KA60.58286760
85BMPR1B0.57415432
86STK30.57167767
87CDK150.55262639
88ILK0.54575210
89TGFBR20.53150991
90PTK20.52531880
91CDK180.51226838
92PAK30.50485372
93NTRK20.50408831
94ADRBK10.49762253
95AURKA0.49430872
96CDK190.48167427
97RIPK10.47203919
98CSK0.46313765
99SIK20.45674016
100CDK140.42984273
101SRC0.41525539
102BMX0.41359556
103CDK70.40904486
104CAMK1D0.40636360
105MAP3K50.38587792
106MAPK70.38326546
107BCR0.38231264
108RPS6KA10.38196485
109WNK10.37572602
110PDGFRB0.37262117
111STK38L0.36900565
112PRKD10.36893039
113MAPK110.36220154
114MAP2K60.35484767
115PLK10.35446612
116EPHA30.35443082
117MAP3K80.34458407
118FER0.33973849
119STK380.32381497
120DYRK1A0.31817999
121PAK20.31497786
122STK240.30494653
123EPHA40.29850374
124MAPKAPK20.27810506
125AKT10.27284677
126CASK0.27226303
127PIK3CG0.26042954
128BRAF0.25356039
129ARAF0.24953604
130RET0.24792768
131EPHA20.24588287
132AURKB0.24525986
133MAPK90.24162324
134CAMK40.22878982
135ATR0.22597255
136CHUK0.22459959
137IGF1R0.21803537
138RPS6KA20.20174549
139PRKD20.19829396
140LMTK20.19823719
141TTK0.17547479

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043304.57826854
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30402616
3Basal cell carcinoma_Homo sapiens_hsa052173.25690278
4Hedgehog signaling pathway_Homo sapiens_hsa043402.83732697
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.72502294
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.44259563
7Dorso-ventral axis formation_Homo sapiens_hsa043202.33486350
8Bladder cancer_Homo sapiens_hsa052192.32470393
9Nitrogen metabolism_Homo sapiens_hsa009102.04568347
10ECM-receptor interaction_Homo sapiens_hsa045122.03243227
11Arginine biosynthesis_Homo sapiens_hsa002202.03173962
12Fatty acid degradation_Homo sapiens_hsa000711.92255777
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88618186
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82669508
15Prion diseases_Homo sapiens_hsa050201.81667991
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.80878931
17MicroRNAs in cancer_Homo sapiens_hsa052061.76659936
18Tryptophan metabolism_Homo sapiens_hsa003801.75629065
19Complement and coagulation cascades_Homo sapiens_hsa046101.65046332
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62481329
21Hippo signaling pathway_Homo sapiens_hsa043901.59597688
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58702421
23Fatty acid metabolism_Homo sapiens_hsa012121.55485413
24Proteoglycans in cancer_Homo sapiens_hsa052051.55444749
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51134863
26Lysine degradation_Homo sapiens_hsa003101.47595017
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45131900
28PPAR signaling pathway_Homo sapiens_hsa033201.39234813
29Axon guidance_Homo sapiens_hsa043601.32256772
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32030415
31Butanoate metabolism_Homo sapiens_hsa006501.30930490
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.30012010
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29912634
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.29769714
35Adherens junction_Homo sapiens_hsa045201.26436063
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21607893
37Dilated cardiomyopathy_Homo sapiens_hsa054141.19340293
38Focal adhesion_Homo sapiens_hsa045101.16635679
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16607971
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13738785
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12284838
42beta-Alanine metabolism_Homo sapiens_hsa004101.08544203
43Small cell lung cancer_Homo sapiens_hsa052221.08213575
44Phenylalanine metabolism_Homo sapiens_hsa003601.05470420
45Propanoate metabolism_Homo sapiens_hsa006401.04507375
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.04472418
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03981780
48Melanoma_Homo sapiens_hsa052181.03638541
49Peroxisome_Homo sapiens_hsa041461.01259915
50Biosynthesis of amino acids_Homo sapiens_hsa012301.00830925
51Endometrial cancer_Homo sapiens_hsa052130.99775747
52Cell cycle_Homo sapiens_hsa041100.96502150
53Thyroid cancer_Homo sapiens_hsa052160.96274365
54TGF-beta signaling pathway_Homo sapiens_hsa043500.95862129
55Arginine and proline metabolism_Homo sapiens_hsa003300.94019481
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.93660818
57Carbon metabolism_Homo sapiens_hsa012000.90377534
58Prostate cancer_Homo sapiens_hsa052150.89689499
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89540704
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.87384096
61Pathways in cancer_Homo sapiens_hsa052000.86064182
62Glioma_Homo sapiens_hsa052140.85540763
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84375763
64Selenocompound metabolism_Homo sapiens_hsa004500.84007536
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83631435
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82501337
67Caffeine metabolism_Homo sapiens_hsa002320.81989784
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80930060
69Chemical carcinogenesis_Homo sapiens_hsa052040.80747341
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.80630903
71Gap junction_Homo sapiens_hsa045400.78766845
72Ras signaling pathway_Homo sapiens_hsa040140.78457090
73Wnt signaling pathway_Homo sapiens_hsa043100.77396352
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75359122
75Tyrosine metabolism_Homo sapiens_hsa003500.75255002
76VEGF signaling pathway_Homo sapiens_hsa043700.74609746
77Estrogen signaling pathway_Homo sapiens_hsa049150.71880660
78Bile secretion_Homo sapiens_hsa049760.70504085
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70247261
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69912366
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69670152
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68169913
83Retinol metabolism_Homo sapiens_hsa008300.67880467
84Viral myocarditis_Homo sapiens_hsa054160.66624192
85Cocaine addiction_Homo sapiens_hsa050300.66473912
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66121530
87Chronic myeloid leukemia_Homo sapiens_hsa052200.65422520
88Amoebiasis_Homo sapiens_hsa051460.65080560
89Starch and sucrose metabolism_Homo sapiens_hsa005000.64802333
90Rap1 signaling pathway_Homo sapiens_hsa040150.64508367
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.63929631
92Melanogenesis_Homo sapiens_hsa049160.63151325
93ErbB signaling pathway_Homo sapiens_hsa040120.62675769
94Spliceosome_Homo sapiens_hsa030400.62562271
95Renal cell carcinoma_Homo sapiens_hsa052110.62421692
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.62380261
97HTLV-I infection_Homo sapiens_hsa051660.61297663
98Base excision repair_Homo sapiens_hsa034100.61182845
99Tight junction_Homo sapiens_hsa045300.60699317
100Pyruvate metabolism_Homo sapiens_hsa006200.59391534
101MAPK signaling pathway_Homo sapiens_hsa040100.58015894
102Choline metabolism in cancer_Homo sapiens_hsa052310.57261689
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56159055
104Histidine metabolism_Homo sapiens_hsa003400.56084806
105Insulin signaling pathway_Homo sapiens_hsa049100.55986816
106GnRH signaling pathway_Homo sapiens_hsa049120.54320648
107AMPK signaling pathway_Homo sapiens_hsa041520.54279658
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53939705
109p53 signaling pathway_Homo sapiens_hsa041150.53763066
110cAMP signaling pathway_Homo sapiens_hsa040240.53515850
111Fat digestion and absorption_Homo sapiens_hsa049750.52925372
112Thyroid hormone synthesis_Homo sapiens_hsa049180.52383273
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51759629
114Cholinergic synapse_Homo sapiens_hsa047250.51648773
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50319306
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50155225
117Oxytocin signaling pathway_Homo sapiens_hsa049210.47421494
118Galactose metabolism_Homo sapiens_hsa000520.46891750
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46687376
120Colorectal cancer_Homo sapiens_hsa052100.46285149
121Staphylococcus aureus infection_Homo sapiens_hsa051500.45774896
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44983506
123Endocytosis_Homo sapiens_hsa041440.44580220
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44488730
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44197294
126Protein digestion and absorption_Homo sapiens_hsa049740.43558158
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42659358
128Steroid biosynthesis_Homo sapiens_hsa001000.42456439
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41448697
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.40930689
131Glutamatergic synapse_Homo sapiens_hsa047240.38966484
132Pancreatic cancer_Homo sapiens_hsa052120.38777230
133Vitamin B6 metabolism_Homo sapiens_hsa007500.37793561
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37720119
135Fatty acid elongation_Homo sapiens_hsa000620.37460498
136Glucagon signaling pathway_Homo sapiens_hsa049220.37188615
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.36700033
138Shigellosis_Homo sapiens_hsa051310.35754719
139N-Glycan biosynthesis_Homo sapiens_hsa005100.34413312
140mRNA surveillance pathway_Homo sapiens_hsa030150.33281454
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.32986741
142mTOR signaling pathway_Homo sapiens_hsa041500.32479317
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32396001
144Insulin resistance_Homo sapiens_hsa049310.31626025
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.30553981
146Inositol phosphate metabolism_Homo sapiens_hsa005620.29234939
147Vibrio cholerae infection_Homo sapiens_hsa051100.29178610
148Pentose phosphate pathway_Homo sapiens_hsa000300.28043469
149Prolactin signaling pathway_Homo sapiens_hsa049170.27722255
150Circadian entrainment_Homo sapiens_hsa047130.27174938

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