ADAMTS20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.77612871
2central nervous system myelination (GO:0022010)5.77612871
3cilium movement (GO:0003341)5.72009395
4neuronal action potential propagation (GO:0019227)5.71144454
5paraxial mesoderm development (GO:0048339)5.70534465
6axoneme assembly (GO:0035082)5.20611281
7axonemal dynein complex assembly (GO:0070286)4.86590712
8sphingosine metabolic process (GO:0006670)4.71139495
9axon ensheathment (GO:0008366)4.54494396
10ensheathment of neurons (GO:0007272)4.54494396
11peripheral nervous system axon ensheathment (GO:0032292)4.47952055
12myelination in peripheral nervous system (GO:0022011)4.47952055
13centriole replication (GO:0007099)4.40932536
14diol metabolic process (GO:0034311)4.31713413
15myelination (GO:0042552)4.31162956
16sphingoid metabolic process (GO:0046519)4.21801811
17regulation of posttranscriptional gene silencing (GO:0060147)4.13639715
18regulation of gene silencing by miRNA (GO:0060964)4.13639715
19regulation of gene silencing by RNA (GO:0060966)4.13639715
20ventricular system development (GO:0021591)4.13144687
21epithelial cilium movement (GO:0003351)4.08386751
22cilium or flagellum-dependent cell motility (GO:0001539)4.04565003
23chromatin remodeling at centromere (GO:0031055)3.95912981
24notochord development (GO:0030903)3.92660215
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.87524025
26regulation of meiosis I (GO:0060631)3.83580148
27neuron cell-cell adhesion (GO:0007158)3.76470364
28CENP-A containing nucleosome assembly (GO:0034080)3.76336197
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.75196543
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.73791667
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.67981615
32presynaptic membrane assembly (GO:0097105)3.66200304
33pre-miRNA processing (GO:0031054)3.65417242
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60694178
35presynaptic membrane organization (GO:0097090)3.59829901
36lateral sprouting from an epithelium (GO:0060601)3.59317438
37L-amino acid import (GO:0043092)3.53677867
38protein localization to synapse (GO:0035418)3.53493404
39glutamate receptor signaling pathway (GO:0007215)3.51968293
40meiotic chromosome segregation (GO:0045132)3.50109192
41translational termination (GO:0006415)3.46638476
42neuron recognition (GO:0008038)3.46054718
43regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.45091759
44axonal fasciculation (GO:0007413)3.41668166
45generation of neurons (GO:0048699)3.36270506
46negative regulation of chromosome segregation (GO:0051985)3.33729240
47positive regulation of SMAD protein import into nucleus (GO:0060391)3.31075676
48oligodendrocyte differentiation (GO:0048709)3.29134116
49viral transcription (GO:0019083)3.27839303
50vocalization behavior (GO:0071625)3.27656418
51neuronal ion channel clustering (GO:0045161)3.27479187
52negative regulation of cell cycle G2/M phase transition (GO:1902750)3.26619074
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.26059149
54negative regulation of sister chromatid segregation (GO:0033046)3.26059149
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26059149
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26059149
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26059149
58mitotic spindle checkpoint (GO:0071174)3.24960597
59histone exchange (GO:0043486)3.24726678
60startle response (GO:0001964)3.23123685
61spindle checkpoint (GO:0031577)3.21600359
62cell-cell junction maintenance (GO:0045217)3.18991039
63eye photoreceptor cell differentiation (GO:0001754)3.17533965
64photoreceptor cell differentiation (GO:0046530)3.17533965
65ribosomal small subunit assembly (GO:0000028)3.15279411
66establishment of integrated proviral latency (GO:0075713)3.14462302
67cerebellar granule cell differentiation (GO:0021707)3.13000117
68DNA methylation involved in gamete generation (GO:0043046)3.11332159
69regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09570875
70protein localization to kinetochore (GO:0034501)3.06909017
71mitotic spindle assembly checkpoint (GO:0007094)3.06592593
72heterochromatin organization (GO:0070828)3.06417000
73motile cilium assembly (GO:0044458)3.05800472
74lysine metabolic process (GO:0006553)3.04618373
75lysine catabolic process (GO:0006554)3.04618373
76centriole assembly (GO:0098534)3.03808406
77nuclear pore organization (GO:0006999)3.03140109
78spindle assembly checkpoint (GO:0071173)3.02541386
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.02475258
80microtubule bundle formation (GO:0001578)3.02335442
81synaptic transmission, glutamatergic (GO:0035249)3.02271022
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01780303
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01392883
84asymmetric protein localization (GO:0008105)3.00403588
85mechanosensory behavior (GO:0007638)2.99865251
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97916010
87nodal signaling pathway (GO:0038092)2.97469136
88prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.95779366
89DNA replication-independent nucleosome organization (GO:0034724)2.95563038
90DNA replication-independent nucleosome assembly (GO:0006336)2.95563038
91regulation of centriole replication (GO:0046599)2.95511866
92cerebral cortex radially oriented cell migration (GO:0021799)2.95031090
93auditory behavior (GO:0031223)2.93085363
94regulation of sister chromatid segregation (GO:0033045)2.92334179
95regulation of mitotic sister chromatid separation (GO:0010965)2.92334179
96regulation of mitotic sister chromatid segregation (GO:0033047)2.92334179
97dendritic spine morphogenesis (GO:0060997)2.91993036
98negative regulation of neurotransmitter transport (GO:0051589)2.91817188
99transmission of nerve impulse (GO:0019226)2.90489443
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90285486
101intraciliary transport (GO:0042073)2.90133524
102negative regulation of mitosis (GO:0045839)2.89999347
103positive regulation of cell cycle G2/M phase transition (GO:1902751)2.89508117
104positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.89508117
105negative regulation of DNA repair (GO:0045738)2.87995776
106nuclear pore complex assembly (GO:0051292)2.87444689
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87440194
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87440194
109mitotic sister chromatid segregation (GO:0000070)2.87180000
110peptidyl-tyrosine autophosphorylation (GO:0038083)2.86706746
111epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.86493379
112sister chromatid segregation (GO:0000819)2.85324312
113protein-chromophore linkage (GO:0018298)2.83360203
114otic vesicle formation (GO:0030916)2.82691438
115dorsal/ventral axis specification (GO:0009950)2.82537171
116limb bud formation (GO:0060174)2.81554093
117DNA double-strand break processing (GO:0000729)2.81062665
118neurotransmitter-gated ion channel clustering (GO:0072578)2.81018689
119neuron-neuron synaptic transmission (GO:0007270)2.80971592
120layer formation in cerebral cortex (GO:0021819)2.80160801
121apical protein localization (GO:0045176)2.79631273
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.79154187
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79154187
124regulation of neuronal synaptic plasticity (GO:0048168)2.79060535
125ribonucleoprotein complex disassembly (GO:0032988)2.78314505
126regulation of helicase activity (GO:0051095)2.77758864
127negative regulation of cell division (GO:0051782)2.77145979
128nerve growth factor signaling pathway (GO:0038180)2.75704877
129innervation (GO:0060384)2.73674372
130L-serine metabolic process (GO:0006563)2.73432063
131genitalia morphogenesis (GO:0035112)2.73389792
132maturation of SSU-rRNA (GO:0030490)2.73153781
133regulation of glutamate receptor signaling pathway (GO:1900449)2.72497324
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71663046
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69311835
136regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.68968713
137reciprocal meiotic recombination (GO:0007131)2.67638429
138reciprocal DNA recombination (GO:0035825)2.67638429
139regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.67569955
140SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67238656
141negative regulation of protein localization to cell surface (GO:2000009)2.67011732
142gamma-aminobutyric acid signaling pathway (GO:0007214)2.66444648
143regulation of chromosome segregation (GO:0051983)2.66041208
144regulation of dendritic spine morphogenesis (GO:0061001)2.65873477
145amino acid import (GO:0043090)2.65360723
146DNA ligation (GO:0006266)2.65230110
147neurotransmitter uptake (GO:0001504)2.65049289
148replication fork processing (GO:0031297)2.64525867
149double-strand break repair via nonhomologous end joining (GO:0006303)2.64178243
150non-recombinational repair (GO:0000726)2.64178243
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64144564
152cotranslational protein targeting to membrane (GO:0006613)2.63563658
153cellular protein complex disassembly (GO:0043624)2.63443981
154glutamate secretion (GO:0014047)2.61363309
155positive regulation of meiosis (GO:0045836)2.61219826
156long-term synaptic potentiation (GO:0060291)2.60250190
157postsynaptic membrane organization (GO:0001941)2.60171664
158midbrain development (GO:0030901)2.59091548
159locomotory exploration behavior (GO:0035641)2.58772328
160DNA replication checkpoint (GO:0000076)2.58369123
161regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58021736
162camera-type eye morphogenesis (GO:0048593)2.57929897
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57734082
164regulation of mitotic spindle checkpoint (GO:1903504)2.57734082
165nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57059668
166long-chain fatty acid biosynthetic process (GO:0042759)2.56586716
167cilium morphogenesis (GO:0060271)2.56578975
168protein targeting to ER (GO:0045047)2.54529213
169cilium organization (GO:0044782)2.54285321
170lung-associated mesenchyme development (GO:0060484)2.54269419
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53848764
172DNA strand elongation involved in DNA replication (GO:0006271)2.53734481
173translational elongation (GO:0006414)2.53315777
174positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52865709
175dendrite morphogenesis (GO:0048813)2.52625651
176cell junction maintenance (GO:0034331)2.52521932
177adult walking behavior (GO:0007628)2.52494288
178regulation of centrosome cycle (GO:0046605)2.52299732
179negative regulation of neurotransmitter secretion (GO:0046929)2.52145961
180regulation of centrosome duplication (GO:0010824)2.51649118
181regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51206775
182cytoskeletal anchoring at plasma membrane (GO:0007016)2.50911927
183regulation of DNA endoreduplication (GO:0032875)2.50204422
184DNA replication-dependent nucleosome assembly (GO:0006335)2.49961326
185synaptic vesicle docking involved in exocytosis (GO:0016081)2.48430307
186establishment of mitochondrion localization (GO:0051654)2.48192344
187central nervous system projection neuron axonogenesis (GO:0021952)2.47302664
188exploration behavior (GO:0035640)2.46383881
189import into cell (GO:0098657)2.45981227
190gamma-aminobutyric acid transport (GO:0015812)2.45509006
191peripheral nervous system development (GO:0007422)2.44698222
192synaptic vesicle exocytosis (GO:0016079)2.43815340
193long-term memory (GO:0007616)2.43425022
194response to auditory stimulus (GO:0010996)2.42238823
195cilium assembly (GO:0042384)2.41497045
196neuron remodeling (GO:0016322)2.40483277
197positive regulation of dendritic spine development (GO:0060999)2.38509072
198cochlea development (GO:0090102)2.36606696
199establishment of nucleus localization (GO:0040023)2.36409513
200fatty acid elongation (GO:0030497)2.36294903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.68292740
2EZH2_22144423_ChIP-Seq_EOC_Human4.09752943
3GBX2_23144817_ChIP-Seq_PC3_Human3.44852691
4IGF1R_20145208_ChIP-Seq_DFB_Human3.28224316
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04012295
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91136617
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75092383
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64610234
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54354324
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.53647569
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53151065
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51882801
13AR_21572438_ChIP-Seq_LNCaP_Human2.39238011
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35507327
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35507327
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35310266
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33566535
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.28673480
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.25415782
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23330827
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22203933
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21483977
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15625083
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14181523
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11759967
26DROSHA_22980978_ChIP-Seq_HELA_Human2.03639493
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02926776
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96655293
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.96055693
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91586999
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.88780116
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.84617030
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.84513308
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84372243
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82721729
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.82654894
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81114397
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80995454
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.80535123
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80058956
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.79981393
42SMAD4_21799915_ChIP-Seq_A2780_Human1.78473419
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77543307
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76354960
45* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72468816
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70859974
47VDR_22108803_ChIP-Seq_LS180_Human1.70823975
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69831096
49* P300_19829295_ChIP-Seq_ESCs_Human1.69416180
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67609533
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.66497788
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66295051
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.65008207
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63500920
55TAF15_26573619_Chip-Seq_HEK293_Human1.62300170
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60765816
57ELK1_19687146_ChIP-ChIP_HELA_Human1.60334394
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.59412402
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59366160
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59238327
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55547941
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.53639406
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53115162
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51838068
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51307753
66TP53_16413492_ChIP-PET_HCT116_Human1.51088873
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50023149
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.47437294
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45896679
70REST_21632747_ChIP-Seq_MESCs_Mouse1.45864875
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43068632
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.42940235
73* STAT3_23295773_ChIP-Seq_U87_Human1.42064606
74AHR_22903824_ChIP-Seq_MCF-7_Human1.40312984
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40172467
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36524414
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36429464
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36173292
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.35625111
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.34719460
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32697717
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.32323532
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32229541
84* FUS_26573619_Chip-Seq_HEK293_Human1.31446226
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29718732
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27697977
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26833043
88MYC_18940864_ChIP-ChIP_HL60_Human1.26064971
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.25966217
90* RARB_27405468_Chip-Seq_BRAIN_Mouse1.25670652
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.24465960
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.23944216
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23603563
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22653198
95ER_23166858_ChIP-Seq_MCF-7_Human1.21895418
96* TP53_18474530_ChIP-ChIP_U2OS_Human1.21793034
97AR_25329375_ChIP-Seq_VCAP_Human1.21648414
98* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21589215
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21145324
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20682075
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19496827
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19305509
103TCF4_23295773_ChIP-Seq_U87_Human1.17277200
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16701407
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16354460
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15714774
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15714774
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15714774
109TTF2_22483619_ChIP-Seq_HELA_Human1.15672703
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15466454
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.14888768
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.13314144
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12480893
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12379948
115MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11426141
116* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10601903
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10396528
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10365521
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10358133
120AR_21909140_ChIP-Seq_LNCAP_Human1.09828982
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.09803786
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.09377453
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08541248
124* AR_19668381_ChIP-Seq_PC3_Human1.08402918
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08225756
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08225756
127BCAT_22108803_ChIP-Seq_LS180_Human1.07477256
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05782100
129RNF2_27304074_Chip-Seq_NSC_Mouse1.05291995
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04895591
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04854703
132NANOG_19829295_ChIP-Seq_ESCs_Human1.04410879
133SOX2_19829295_ChIP-Seq_ESCs_Human1.04410879
134NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04211552
135RUNX2_22187159_ChIP-Seq_PCA_Human1.03992669
136* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03342982
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.03264632
138* SOX9_26525672_Chip-Seq_HEART_Mouse1.02634765
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.02064454
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01922548
141TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01416657
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01300290
143* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00429240
144EWS_26573619_Chip-Seq_HEK293_Human1.00383644
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00291628
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99900183
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99771373
148ZNF274_21170338_ChIP-Seq_K562_Hela0.97492071
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96822638
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96822638
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96725690
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96512392
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.96469663
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.96264335
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94754244
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.94238047
157CBP_20019798_ChIP-Seq_JUKART_Human0.94166963
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94166963
159FOXP3_21729870_ChIP-Seq_TREG_Human0.93574718
160TCF4_22108803_ChIP-Seq_LS180_Human0.93566124
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90654929
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90627584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry4.24233137
2MP0002837_dystrophic_cardiac_calcinosis4.21750254
3MP0004859_abnormal_synaptic_plasticity4.02336242
4MP0003880_abnormal_central_pattern3.81885548
5MP0002653_abnormal_ependyma_morphology3.49124226
6MP0004270_analgesia3.21731493
7MP0000920_abnormal_myelination3.16494379
8MP0010030_abnormal_orbit_morphology2.96069293
9MP0004272_abnormal_basement_membrane2.87174577
10MP0001968_abnormal_touch/_nociception2.64156135
11MP0003635_abnormal_synaptic_transmissio2.60986344
12MP0002272_abnormal_nervous_system2.60187271
13MP0003941_abnormal_skin_development2.59551187
14MP0009046_muscle_twitch2.43556984
15MP0000537_abnormal_urethra_morphology2.41655198
16MP0010094_abnormal_chromosome_stability2.41401026
17MP0005623_abnormal_meninges_morphology2.39705633
18MP0001486_abnormal_startle_reflex2.28445346
19MP0002064_seizures2.26740410
20MP0008438_abnormal_cutaneous_collagen2.24358124
21MP0004145_abnormal_muscle_electrophysio2.23790486
22MP0009745_abnormal_behavioral_response2.20165865
23MP0000778_abnormal_nervous_system2.18912887
24MP0003634_abnormal_glial_cell2.16061469
25MP0002734_abnormal_mechanical_nocicepti2.15089965
26MP0001293_anophthalmia2.12282500
27MP0003950_abnormal_plasma_membrane2.11344738
28MP0004957_abnormal_blastocyst_morpholog2.10801872
29MP0006292_abnormal_olfactory_placode2.09660367
30MP0005171_absent_coat_pigmentation2.03664065
31MP0001501_abnormal_sleep_pattern2.01009606
32* MP0002938_white_spotting1.98593007
33MP0002063_abnormal_learning/memory/cond1.98361214
34MP0003646_muscle_fatigue1.98138800
35MP0000751_myopathy1.96387982
36MP0002572_abnormal_emotion/affect_behav1.90214075
37MP0008057_abnormal_DNA_replication1.89236311
38MP0001346_abnormal_lacrimal_gland1.87712091
39MP0002736_abnormal_nociception_after1.86283518
40MP0002067_abnormal_sensory_capabilities1.85253228
41MP0003693_abnormal_embryo_hatching1.85226281
42MP0008058_abnormal_DNA_repair1.82675884
43MP0002697_abnormal_eye_size1.80330756
44MP0005503_abnormal_tendon_morphology1.73774000
45MP0003119_abnormal_digestive_system1.69229766
46MP0003111_abnormal_nucleus_morphology1.64135124
47MP0008569_lethality_at_weaning1.62530729
48MP0004858_abnormal_nervous_system1.62488272
49MP0005409_darkened_coat_color1.56928005
50MP0004142_abnormal_muscle_tone1.55945269
51MP0005423_abnormal_somatic_nervous1.54415050
52MP0004885_abnormal_endolymph1.52576643
53MP0003690_abnormal_glial_cell1.49123243
54MP0002638_abnormal_pupillary_reflex1.48244659
55MP0001286_abnormal_eye_development1.46012100
56MP0000747_muscle_weakness1.45560316
57MP0003632_abnormal_nervous_system1.44798554
58MP0004742_abnormal_vestibular_system1.43720230
59MP0001299_abnormal_eye_distance/1.42780245
60MP0002084_abnormal_developmental_patter1.42579519
61MP0001440_abnormal_grooming_behavior1.42069927
62MP0002557_abnormal_social/conspecific_i1.41237688
63MP0002751_abnormal_autonomic_nervous1.40733357
64MP0009672_abnormal_birth_weight1.40655519
65MP0003077_abnormal_cell_cycle1.40140258
66* MP0008932_abnormal_embryonic_tissue1.39566059
67MP0001984_abnormal_olfaction1.38880463
68MP0002233_abnormal_nose_morphology1.38280602
69MP0002184_abnormal_innervation1.37433053
70MP0000579_abnormal_nail_morphology1.36747432
71MP0000955_abnormal_spinal_cord1.36343624
72MP0002882_abnormal_neuron_morphology1.34618393
73MP0003718_maternal_effect1.34270599
74* MP0003136_yellow_coat_color1.34006560
75MP0004133_heterotaxia1.33106300
76MP0002735_abnormal_chemical_nociception1.32298833
77MP0003122_maternal_imprinting1.29063597
78MP0003329_amyloid_beta_deposits1.29005466
79MP0002254_reproductive_system_inflammat1.28759180
80MP0001188_hyperpigmentation1.28257811
81MP0009379_abnormal_foot_pigmentation1.27577654
82MP0003878_abnormal_ear_physiology1.27382977
83MP0005377_hearing/vestibular/ear_phenot1.27382977
84MP0002102_abnormal_ear_morphology1.27121804
85MP0003045_fibrosis1.26967481
86MP0002108_abnormal_muscle_morphology1.26825114
87MP0000569_abnormal_digit_pigmentation1.23075902
88MP0002733_abnormal_thermal_nociception1.22193686
89MP0001970_abnormal_pain_threshold1.22103863
90MP0003631_nervous_system_phenotype1.20995825
91MP0008789_abnormal_olfactory_epithelium1.20016469
92MP0002249_abnormal_larynx_morphology1.19249831
93MP0001661_extended_life_span1.18661201
94MP0008877_abnormal_DNA_methylation1.17667152
95MP0000383_abnormal_hair_follicle1.14801440
96MP0001177_atelectasis1.14681759
97MP0010678_abnormal_skin_adnexa1.12824405
98MP0000566_synostosis1.10522842
99MP0002066_abnormal_motor_capabilities/c1.09775043
100MP0003938_abnormal_ear_development1.09511558
101* MP0002085_abnormal_embryonic_tissue1.09422687
102MP0002111_abnormal_tail_morphology1.08979115
103MP0005275_abnormal_skin_tensile1.08938408
104MP0010352_gastrointestinal_tract_polyps1.06428570
105MP0006072_abnormal_retinal_apoptosis1.06200233
106MP0001502_abnormal_circadian_rhythm1.05909588
107MP0009697_abnormal_copulation1.05318069
108MP0009250_abnormal_appendicular_skeleto1.04919095
109MP0003633_abnormal_nervous_system1.04825462
110MP0001324_abnormal_eye_pigmentation1.04744261
111MP0001485_abnormal_pinna_reflex1.04742032
112MP0005646_abnormal_pituitary_gland1.04514474
113MP0005386_behavior/neurological_phenoty1.04464231
114MP0004924_abnormal_behavior1.04464231
115MP0003567_abnormal_fetal_cardiomyocyte1.01706130
116MP0002752_abnormal_somatic_nervous1.01027488
117MP0002152_abnormal_brain_morphology1.00577217
118MP0001963_abnormal_hearing_physiology1.00470496
119MP0002160_abnormal_reproductive_system1.00008602
120MP0004811_abnormal_neuron_physiology0.99799144
121MP0009053_abnormal_anal_canal0.98183517
122MP0005551_abnormal_eye_electrophysiolog0.97968821
123MP0000749_muscle_degeneration0.97830508
124MP0005253_abnormal_eye_physiology0.97627512
125MP0003121_genomic_imprinting0.96343526
126MP0002229_neurodegeneration0.95704375
127MP0003283_abnormal_digestive_organ0.94541936
128MP0001672_abnormal_embryogenesis/_devel0.93691707
129MP0005380_embryogenesis_phenotype0.93691707
130MP0002210_abnormal_sex_determination0.92734070
131MP0009703_decreased_birth_body0.92167471
132MP0003755_abnormal_palate_morphology0.90991770
133MP0006276_abnormal_autonomic_nervous0.90812125
134MP0000432_abnormal_head_morphology0.90796332
135MP0003942_abnormal_urinary_system0.90005639
136MP0005391_vision/eye_phenotype0.89394810
137MP0000462_abnormal_digestive_system0.89113301
138MP0000026_abnormal_inner_ear0.88279363
139MP0008260_abnormal_autophagy0.87635175
140MP0000427_abnormal_hair_cycle0.86395491
141MP0003195_calcinosis0.86332618
142MP0010307_abnormal_tumor_latency0.85971027
143* MP0003937_abnormal_limbs/digits/tail_de0.85888116
144MP0001697_abnormal_embryo_size0.85744211
145MP0001905_abnormal_dopamine_level0.85649840
146MP0005248_abnormal_Harderian_gland0.85123837
147MP0000631_abnormal_neuroendocrine_gland0.84543671
148MP0001145_abnormal_male_reproductive0.84503177
149MP0003315_abnormal_perineum_morphology0.83853659
150MP0005395_other_phenotype0.83130803
151MP0000049_abnormal_middle_ear0.82820512
152MP0000762_abnormal_tongue_morphology0.82535973
153MP0005187_abnormal_penis_morphology0.82390639
154MP0001529_abnormal_vocalization0.82188570
155MP0000428_abnormal_craniofacial_morphol0.81926921
156* MP0003861_abnormal_nervous_system0.81911985
157MP0005499_abnormal_olfactory_system0.80968957
158MP0005394_taste/olfaction_phenotype0.80968957
159MP0004233_abnormal_muscle_weight0.80149627
160MP0003935_abnormal_craniofacial_develop0.79940176
161MP0000653_abnormal_sex_gland0.79037264
162MP0005367_renal/urinary_system_phenotyp0.78699866
163MP0000516_abnormal_urinary_system0.78699866
164MP0004197_abnormal_fetal_growth/weight/0.78514642
165MP0000534_abnormal_ureter_morphology0.78331801
166MP0004484_altered_response_of0.77069254
167MP0003385_abnormal_body_wall0.75893361
168MP0001929_abnormal_gametogenesis0.75100477
169MP0002822_catalepsy0.74947083
170MP0003879_abnormal_hair_cell0.74854413
171MP0005085_abnormal_gallbladder_physiolo0.74812032
172MP0002116_abnormal_craniofacial_bone0.73680325
173MP0004134_abnormal_chest_morphology0.72505882
174MP0009780_abnormal_chondrocyte_physiolo0.71119007
175MP0001943_abnormal_respiration0.70136206

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.53012325
2Abnormal ciliary motility (HP:0012262)6.83663999
3Insidious onset (HP:0003587)6.63085426
4Termporal pattern (HP:0011008)6.63085426
5Abnormal respiratory motile cilium physiology (HP:0012261)6.38155638
6Segmental peripheral demyelination/remyelination (HP:0003481)5.98654475
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.63641106
8Action tremor (HP:0002345)5.26576164
9Impaired proprioception (HP:0010831)4.66209074
10Peripheral hypomyelination (HP:0007182)4.50880542
11Abnormal respiratory motile cilium morphology (HP:0005938)4.47734456
12Abnormal respiratory epithelium morphology (HP:0012253)4.47734456
13Colon cancer (HP:0003003)4.44600080
14Rhinitis (HP:0012384)4.42760244
15Onion bulb formation (HP:0003383)4.10345813
16Absent/shortened dynein arms (HP:0200106)4.08525216
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.08525216
18Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00737954
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.85216530
20Chromsome breakage (HP:0040012)3.74747060
21Steppage gait (HP:0003376)3.67030797
22Reticulocytopenia (HP:0001896)3.50812493
23Hammertoe (HP:0001765)3.45423794
24Increased CSF protein (HP:0002922)3.39248574
25Pancreatic cysts (HP:0001737)3.26846236
26Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.26376183
27Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.21255796
28Focal motor seizures (HP:0011153)3.14676326
29Decreased motor nerve conduction velocity (HP:0003431)3.09006025
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08334395
31Degeneration of the lateral corticospinal tracts (HP:0002314)3.08334395
32Meckel diverticulum (HP:0002245)2.87609870
33Abnormality of chromosome stability (HP:0003220)2.86479028
34Foot dorsiflexor weakness (HP:0009027)2.83753006
35Upper limb muscle weakness (HP:0003484)2.83062073
36Abnormality of the ileum (HP:0001549)2.82153424
37Acanthocytosis (HP:0001927)2.81190216
38Amelogenesis imperfecta (HP:0000705)2.79541759
39Septo-optic dysplasia (HP:0100842)2.70812068
40Abnormality of the foot musculature (HP:0001436)2.70750963
41Abnormality of the corticospinal tract (HP:0002492)2.65694994
42Abnormality of the labia minora (HP:0012880)2.65427354
43Occipital encephalocele (HP:0002085)2.64444222
44Postural tremor (HP:0002174)2.60789476
45True hermaphroditism (HP:0010459)2.58702560
46Triphalangeal thumb (HP:0001199)2.58692364
47Abnormal sex determination (HP:0012244)2.57468226
48Sex reversal (HP:0012245)2.57468226
49Pancreatic fibrosis (HP:0100732)2.57235976
50Stenosis of the external auditory canal (HP:0000402)2.52326293
51Peripheral demyelination (HP:0011096)2.46804708
52Ectopic kidney (HP:0000086)2.45851688
53Volvulus (HP:0002580)2.44904435
54Cutaneous finger syndactyly (HP:0010554)2.43676404
55Myokymia (HP:0002411)2.40180499
56Absent radius (HP:0003974)2.39206224
57Focal seizures (HP:0007359)2.38565147
58Neurofibrillary tangles (HP:0002185)2.35128427
59Birth length less than 3rd percentile (HP:0003561)2.32540125
60Abnormality of the preputium (HP:0100587)2.31598602
61Bifid tongue (HP:0010297)2.27999051
62Bilateral microphthalmos (HP:0007633)2.27753763
63Absent forearm bone (HP:0003953)2.25336204
64Aplasia involving forearm bones (HP:0009822)2.25336204
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22845430
66Gastrointestinal atresia (HP:0002589)2.20588406
67Short hallux (HP:0010109)2.20361680
68Bronchiectasis (HP:0002110)2.17299447
69Embryonal renal neoplasm (HP:0011794)2.15847456
70Synostosis of carpal bones (HP:0005048)2.15416246
71Preaxial foot polydactyly (HP:0001841)2.14813208
72Abnormal lung lobation (HP:0002101)2.13482317
73Cutaneous syndactyly (HP:0012725)2.13364120
74Nephroblastoma (Wilms tumor) (HP:0002667)2.13300848
75Duplication of thumb phalanx (HP:0009942)2.12697672
76Dialeptic seizures (HP:0011146)2.12596120
77Anencephaly (HP:0002323)2.12341280
78Epileptic encephalopathy (HP:0200134)2.11794462
79Anophthalmia (HP:0000528)2.11022734
80Enlarged kidneys (HP:0000105)2.06312585
81Small intestinal stenosis (HP:0012848)2.06144626
82Duodenal stenosis (HP:0100867)2.06144626
83Sloping forehead (HP:0000340)2.05596753
84Aplasia/Hypoplasia of the hallux (HP:0008362)2.05565342
85Myelomeningocele (HP:0002475)2.05092424
86Intestinal atresia (HP:0011100)2.04440832
87Hyperglycinemia (HP:0002154)2.04110050
88Coronal craniosynostosis (HP:0004440)2.04081921
89Hyperglycinuria (HP:0003108)2.03260590
90Abnormal number of erythroid precursors (HP:0012131)2.02379910
91Spastic gait (HP:0002064)2.01771230
92Chronic bronchitis (HP:0004469)2.00604337
93Abnormality of cells of the erythroid lineage (HP:0012130)2.00035620
94Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00035586
95Abnormality of the renal medulla (HP:0100957)1.99051555
962-3 toe syndactyly (HP:0004691)1.96960435
97Abnormal auditory evoked potentials (HP:0006958)1.96672221
98Midline defect of the nose (HP:0004122)1.96264306
99Alacrima (HP:0000522)1.95978970
100Medulloblastoma (HP:0002885)1.95878085
101Abnormality of the duodenum (HP:0002246)1.95147596
102Partial duplication of thumb phalanx (HP:0009944)1.94076432
103Cystic liver disease (HP:0006706)1.93872190
104Absent septum pellucidum (HP:0001331)1.92977329
105Abnormality of the vocal cords (HP:0008777)1.92227387
106Cerebral inclusion bodies (HP:0100314)1.90786996
107Duplicated collecting system (HP:0000081)1.90427806
108Preaxial hand polydactyly (HP:0001177)1.89103344
109Partial duplication of the phalanx of hand (HP:0009999)1.88663376
110Bell-shaped thorax (HP:0001591)1.87513180
111Aqueductal stenosis (HP:0002410)1.87067930
112Bronchomalacia (HP:0002780)1.85850414
113Neoplasm of the colon (HP:0100273)1.85703005
114Split foot (HP:0001839)1.85672221
115Aplasia involving bones of the extremities (HP:0009825)1.84937879
116Aplasia involving bones of the upper limbs (HP:0009823)1.84937879
117Aplasia of the phalanges of the hand (HP:0009802)1.84937879
118Abnormality of the parietal bone (HP:0002696)1.83923499
119Proximal amyotrophy (HP:0007126)1.83879114
120Shallow orbits (HP:0000586)1.83244809
121Supernumerary spleens (HP:0009799)1.82274717
122Hypoplasia of the pons (HP:0012110)1.82128786
123Hyperventilation (HP:0002883)1.81256684
124Severe Myopia (HP:0011003)1.81043284
125Neonatal short-limb short stature (HP:0008921)1.80876136
126Aplastic anemia (HP:0001915)1.80465476
127Broad metatarsal (HP:0001783)1.80456321
128Dysmetria (HP:0001310)1.79900418
129Abnormality of the pons (HP:0007361)1.79514971
130Lower limb muscle weakness (HP:0007340)1.78821783
131Short thumb (HP:0009778)1.78596352
132Hypoplastic labia majora (HP:0000059)1.78343293
133Decreased lacrimation (HP:0000633)1.77785711
134Abnormality of the septum pellucidum (HP:0007375)1.77263028
135Oligodactyly (hands) (HP:0001180)1.77141112
136Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.77002996
137Hyperinsulinemic hypoglycemia (HP:0000825)1.76096405
138Macrocytic anemia (HP:0001972)1.74682045
139Gait imbalance (HP:0002141)1.74527976
140Absent eyebrow (HP:0002223)1.73863811
141Clubbing of toes (HP:0100760)1.72984721
142Fibular hypoplasia (HP:0003038)1.72912371
143Urinary bladder sphincter dysfunction (HP:0002839)1.72692049
144Megalencephaly (HP:0001355)1.71378728
145Hepatoblastoma (HP:0002884)1.70384632
146Genital tract atresia (HP:0001827)1.70360980
147Hypomagnesemia (HP:0002917)1.70150755
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.70032322
149Progressive cerebellar ataxia (HP:0002073)1.68400855
150Impulsivity (HP:0100710)1.67053738
151Abnormality of the carotid arteries (HP:0005344)1.65376948
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.65285779
153Abnormality of the middle phalanges of the toes (HP:0010183)1.64729278
154Atonic seizures (HP:0010819)1.64424794
155Esophageal atresia (HP:0002032)1.64278715
156Dandy-Walker malformation (HP:0001305)1.63764947
157Sclerocornea (HP:0000647)1.63409786
158Distal sensory impairment (HP:0002936)1.63329553
159Excessive salivation (HP:0003781)1.63108713
160Drooling (HP:0002307)1.63108713
161Cortical dysplasia (HP:0002539)1.62947342
162Abnormality of dentin (HP:0010299)1.62819287
163Type I transferrin isoform profile (HP:0003642)1.62619161
164Cerebellar dysplasia (HP:0007033)1.62505190
165Thickened helices (HP:0000391)1.61977009
166Cupped ear (HP:0000378)1.61529110
167Postaxial foot polydactyly (HP:0001830)1.60579850
168Urinary urgency (HP:0000012)1.60307619
169Ankle clonus (HP:0011448)1.60073070
170Dysdiadochokinesis (HP:0002075)1.59994984
171Premature rupture of membranes (HP:0001788)1.59894589
172Abnormality of the renal collecting system (HP:0004742)1.59542822
173Abnormal pupillary function (HP:0007686)1.59269466
174Anteriorly placed anus (HP:0001545)1.58726138
175Medial flaring of the eyebrow (HP:0010747)1.56561510
176Chronic sinusitis (HP:0011109)1.55419478
177Vaginal atresia (HP:0000148)1.54187547
178Nephronophthisis (HP:0000090)1.53891707
179Genetic anticipation (HP:0003743)1.53543577
180Congenital primary aphakia (HP:0007707)1.53087814
181Omphalocele (HP:0001539)1.52743738
182Humeroradial synostosis (HP:0003041)1.52517327
183Synostosis involving the elbow (HP:0003938)1.52517327
184Gaze-evoked nystagmus (HP:0000640)1.52067768
185Retinal dysplasia (HP:0007973)1.51998067
186Broad-based gait (HP:0002136)1.50470387
187Abnormal biliary tract physiology (HP:0012439)1.49608679
188Bile duct proliferation (HP:0001408)1.49608679
189Clumsiness (HP:0002312)1.48770493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.67805052
2STK38L5.10212518
3PNCK4.50855310
4LATS23.96873412
5ZAK3.77292458
6STK393.35458025
7NTRK33.22802206
8CASK2.92399534
9EPHA42.86874629
10TNIK2.86756696
11NTRK22.59452647
12MKNK22.49503658
13BUB12.47054950
14ACVR1B2.43449550
15BMPR1B2.39655493
16MKNK12.35197622
17TTK2.32868151
18TAF12.32464971
19FRK2.25775091
20MAPK152.20276670
21CDC72.15617288
22STK32.08910607
23NLK2.06453437
24OXSR11.95795130
25IRAK21.93826765
26MAP3K41.89589791
27NTRK11.84872396
28WNK31.82177493
29VRK21.79963414
30MARK11.68522338
31PLK41.66977432
32SRPK11.62141614
33NEK21.61709806
34FGFR21.59833294
35PASK1.56631083
36PRKD31.54378626
37WNK11.54055771
38CAMK1G1.52045730
39WNK41.48816639
40MAP2K71.44431351
41TGFBR11.42216921
42DMPK1.41338210
43PLK31.40432840
44MAPK131.38229384
45IRAK11.37820155
46BCR1.37495193
47UHMK11.33752945
48MARK21.33720970
49NME11.33330707
50PKN11.30333179
51NUAK11.28737721
52PAK61.26585708
53FGR1.26107552
54CAMK2B1.20609615
55CDK51.19789308
56EPHB11.18587199
57PLK21.17971383
58MELK1.17811646
59CSNK1A1L1.16718534
60PTK2B1.15984087
61VRK11.15287104
62PLK11.14670447
63SGK2231.14052514
64SGK4941.14052514
65ROCK21.12203443
66TSSK61.11828663
67NEK61.11139617
68ICK1.09478183
69MINK11.09055147
70CHEK21.05544246
71CSNK1G21.04032002
72PAK31.03368093
73CAMK2A1.02555897
74WEE11.01446965
75STK161.00738415
76ATR0.96953813
77CSNK1G10.96750002
78RIPK40.96640449
79BRSK20.94974739
80KSR10.94303476
81CSNK1G30.94122547
82PHKG10.93333292
83PHKG20.93333292
84PRPF4B0.90777712
85STK380.90512572
86BMPR20.90230551
87DAPK20.89386876
88MAPKAPK50.88458939
89MET0.83538026
90PRKCG0.82764507
91BRD40.82429088
92TRIM280.81812216
93MAP2K20.81444709
94CAMK2D0.81138533
95NEK10.80755066
96PRKCE0.77727835
97DYRK20.76203938
98FER0.75793132
99STK240.75784220
100EIF2AK30.74618637
101INSRR0.72544827
102TYRO30.70463296
103GRK50.67673095
104EPHB20.67261884
105PBK0.67244626
106FGFR10.66260322
107AURKB0.66010604
108PRKCQ0.65707841
109STK110.65260876
110ROCK10.64944426
111MAP3K70.64013614
112ATM0.63627047
113MAP2K40.62882514
114CAMK2G0.62568418
115DDR20.60931673
116ADRBK20.60738378
117PRKCH0.60243316
118CDK140.59473593
119CDK150.59106392
120CDK180.58787380
121TLK10.56905040
122FYN0.55189239
123CDK190.54537764
124SGK10.54103986
125DYRK1A0.53150405
126CDK30.51424393
127CAMKK10.50879444
128CDC42BPA0.50856642
129SIK10.49613603
130MAPK100.49209723
131ERBB20.49057435
132GSK3A0.48804577
133DYRK30.48509217
134LIMK10.48406134
135CDK11A0.48342634
136PRKG10.47251786
137SGK20.47166530
138RET0.45382797
139FES0.45062675
140MAP3K60.44909350
141PINK10.44825791
142CHEK10.44490938
143PRKD10.43082798
144MAP3K20.42625800
145RPS6KA30.41469579
146PTK60.40842316
147EIF2AK20.40431857
148CLK10.40420882
149CAMK10.40166339
150MAP3K100.39990437
151KSR20.38791230
152PIK3CA0.38029686
153PRKAA20.36656715
154PRKDC0.36454780
155CAMK1D0.35259208
156CDK10.34139205
157ADRBK10.33841178
158CDK20.33423616
159GRK10.29617066
160BRSK10.28800734
161CSNK1D0.28650997
162PIM10.27889887
163GRK70.27472093
164CSNK1E0.27343706
165CDK40.26698405
166STK40.24231027
167CSNK2A10.23996502
168CDK70.23500394
169AURKA0.23220877
170CSNK2A20.21777007
171ALK0.21555870
172PRKACB0.21385313
173PIK3CG0.20292980
174ERBB40.19097441
175CSNK1A10.17252440

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.26031719
2Nicotine addiction_Homo sapiens_hsa050333.16181259
3Ribosome_Homo sapiens_hsa030103.09781288
4Mismatch repair_Homo sapiens_hsa034303.02856731
5Homologous recombination_Homo sapiens_hsa034402.92537555
6DNA replication_Homo sapiens_hsa030302.61740734
7Glutamatergic synapse_Homo sapiens_hsa047242.49950048
8Circadian entrainment_Homo sapiens_hsa047132.49568781
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48258707
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31663394
11Fanconi anemia pathway_Homo sapiens_hsa034602.24390334
12GABAergic synapse_Homo sapiens_hsa047272.24007441
13Amphetamine addiction_Homo sapiens_hsa050312.19556339
14Axon guidance_Homo sapiens_hsa043602.12072626
15One carbon pool by folate_Homo sapiens_hsa006702.11327450
16Long-term potentiation_Homo sapiens_hsa047202.08882387
17Morphine addiction_Homo sapiens_hsa050322.00518991
18Cell cycle_Homo sapiens_hsa041101.98201043
19Basal transcription factors_Homo sapiens_hsa030221.90583087
20Salivary secretion_Homo sapiens_hsa049701.89601918
21RNA polymerase_Homo sapiens_hsa030201.86609545
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.81306538
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79247992
24Serotonergic synapse_Homo sapiens_hsa047261.77617896
25Long-term depression_Homo sapiens_hsa047301.76978901
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73999213
27Dopaminergic synapse_Homo sapiens_hsa047281.70604076
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69317862
29Renin secretion_Homo sapiens_hsa049241.68573003
30Dorso-ventral axis formation_Homo sapiens_hsa043201.67140386
31RNA transport_Homo sapiens_hsa030131.67099474
32Gastric acid secretion_Homo sapiens_hsa049711.65417126
33Taste transduction_Homo sapiens_hsa047421.61721760
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61494348
35Spliceosome_Homo sapiens_hsa030401.61069773
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60765255
37Insulin secretion_Homo sapiens_hsa049111.60182440
38Cocaine addiction_Homo sapiens_hsa050301.57659157
39Hedgehog signaling pathway_Homo sapiens_hsa043401.55579447
40Olfactory transduction_Homo sapiens_hsa047401.55347597
41Calcium signaling pathway_Homo sapiens_hsa040201.53217552
42Cholinergic synapse_Homo sapiens_hsa047251.51804943
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46874899
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40629052
45Oxidative phosphorylation_Homo sapiens_hsa001901.37021834
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36944233
47Dilated cardiomyopathy_Homo sapiens_hsa054141.35884861
48ECM-receptor interaction_Homo sapiens_hsa045121.35661474
49Selenocompound metabolism_Homo sapiens_hsa004501.35319023
50RNA degradation_Homo sapiens_hsa030181.35131477
51cAMP signaling pathway_Homo sapiens_hsa040241.33417702
52Oxytocin signaling pathway_Homo sapiens_hsa049211.31922814
53Gap junction_Homo sapiens_hsa045401.31872726
54Nucleotide excision repair_Homo sapiens_hsa034201.31448318
55Huntingtons disease_Homo sapiens_hsa050161.28500780
56Steroid biosynthesis_Homo sapiens_hsa001001.25632939
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25328278
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24210881
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21986351
60TGF-beta signaling pathway_Homo sapiens_hsa043501.21193260
61Propanoate metabolism_Homo sapiens_hsa006401.21088063
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20631769
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20501361
64GnRH signaling pathway_Homo sapiens_hsa049121.20302101
65Synaptic vesicle cycle_Homo sapiens_hsa047211.17698968
66Nitrogen metabolism_Homo sapiens_hsa009101.15580650
67Ether lipid metabolism_Homo sapiens_hsa005651.15123410
68N-Glycan biosynthesis_Homo sapiens_hsa005101.14903603
69Base excision repair_Homo sapiens_hsa034101.14530579
70Estrogen signaling pathway_Homo sapiens_hsa049151.11145867
71Parkinsons disease_Homo sapiens_hsa050121.10548728
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09515519
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08834497
74Melanogenesis_Homo sapiens_hsa049161.08412835
75cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08035107
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07489467
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07099682
78Vascular smooth muscle contraction_Homo sapiens_hsa042701.06358071
79ErbB signaling pathway_Homo sapiens_hsa040121.05419208
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04413889
81Purine metabolism_Homo sapiens_hsa002301.03636041
82Pyruvate metabolism_Homo sapiens_hsa006201.03608944
83Protein export_Homo sapiens_hsa030601.00892291
84mRNA surveillance pathway_Homo sapiens_hsa030151.00593367
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00171225
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98420460
87Lysine degradation_Homo sapiens_hsa003100.98236846
88Fatty acid elongation_Homo sapiens_hsa000620.97198626
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96390463
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95943722
91Adherens junction_Homo sapiens_hsa045200.94073043
92Basal cell carcinoma_Homo sapiens_hsa052170.93181568
93Biosynthesis of amino acids_Homo sapiens_hsa012300.90604417
94Tryptophan metabolism_Homo sapiens_hsa003800.90457298
95Ras signaling pathway_Homo sapiens_hsa040140.90377817
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89657535
97Proteasome_Homo sapiens_hsa030500.89325411
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89212071
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.88019784
100Pancreatic secretion_Homo sapiens_hsa049720.87460262
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87282937
102Wnt signaling pathway_Homo sapiens_hsa043100.86838935
103Pyrimidine metabolism_Homo sapiens_hsa002400.86079263
104Vitamin digestion and absorption_Homo sapiens_hsa049770.85202579
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.84788522
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84199933
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83707058
108Thyroid cancer_Homo sapiens_hsa052160.80963316
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78917200
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77984261
111Tight junction_Homo sapiens_hsa045300.77545817
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76629194
113Focal adhesion_Homo sapiens_hsa045100.76309987
114MAPK signaling pathway_Homo sapiens_hsa040100.75838920
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75766852
116Protein digestion and absorption_Homo sapiens_hsa049740.73079107
117Phototransduction_Homo sapiens_hsa047440.72782057
118Rap1 signaling pathway_Homo sapiens_hsa040150.72141276
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71586985
120Alcoholism_Homo sapiens_hsa050340.71523508
121Thyroid hormone synthesis_Homo sapiens_hsa049180.71097921
122Glioma_Homo sapiens_hsa052140.70144029
123Ovarian steroidogenesis_Homo sapiens_hsa049130.69916301
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69569013
125Choline metabolism in cancer_Homo sapiens_hsa052310.68680935
126Colorectal cancer_Homo sapiens_hsa052100.68642649
127p53 signaling pathway_Homo sapiens_hsa041150.68102211
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64469082
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64073831
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.63476945
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62166881
132Renal cell carcinoma_Homo sapiens_hsa052110.60938441
133Cardiac muscle contraction_Homo sapiens_hsa042600.60737616
134beta-Alanine metabolism_Homo sapiens_hsa004100.60166470
135Circadian rhythm_Homo sapiens_hsa047100.60122630
136Alzheimers disease_Homo sapiens_hsa050100.60069564
137Amoebiasis_Homo sapiens_hsa051460.59601600
138Prion diseases_Homo sapiens_hsa050200.58336319
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58305171
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.57997147
141Hippo signaling pathway_Homo sapiens_hsa043900.56782811
142Glutathione metabolism_Homo sapiens_hsa004800.56546846
143African trypanosomiasis_Homo sapiens_hsa051430.56336589
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56128811
145Metabolic pathways_Homo sapiens_hsa011000.55305055
146Arginine and proline metabolism_Homo sapiens_hsa003300.55198767
147Type II diabetes mellitus_Homo sapiens_hsa049300.55154565
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53928636
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53726504
150Systemic lupus erythematosus_Homo sapiens_hsa053220.53416654
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51138812
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50947717
153Folate biosynthesis_Homo sapiens_hsa007900.49931714
154Butanoate metabolism_Homo sapiens_hsa006500.48034526
155Glycerolipid metabolism_Homo sapiens_hsa005610.47408957
156Mineral absorption_Homo sapiens_hsa049780.47217572
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46945785
158Collecting duct acid secretion_Homo sapiens_hsa049660.46072997
159Sphingolipid metabolism_Homo sapiens_hsa006000.44400384
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.43963421
161Vitamin B6 metabolism_Homo sapiens_hsa007500.43461484
162Oocyte meiosis_Homo sapiens_hsa041140.43004077
163Histidine metabolism_Homo sapiens_hsa003400.41543790
1642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41451089
165PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41207803
166Endocytosis_Homo sapiens_hsa041440.39574998
167Retinol metabolism_Homo sapiens_hsa008300.39244627
168Inositol phosphate metabolism_Homo sapiens_hsa005620.39064917
169Steroid hormone biosynthesis_Homo sapiens_hsa001400.38804877

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