ADAM29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.89201205
2binding of sperm to zona pellucida (GO:0007339)9.74036539
3epithelial cilium movement (GO:0003351)9.63446409
4spermatid development (GO:0007286)8.67853795
5single fertilization (GO:0007338)8.02767815
6cilium movement (GO:0003341)8.01213579
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.96144701
8regulation of cilium movement (GO:0003352)7.34909565
9sperm capacitation (GO:0048240)7.00929007
10male meiosis (GO:0007140)6.97841101
11piRNA metabolic process (GO:0034587)6.63184722
12fertilization (GO:0009566)6.33224119
13synaptonemal complex organization (GO:0070193)6.26006793
14microtubule depolymerization (GO:0007019)6.17498577
15synaptonemal complex assembly (GO:0007130)6.00069017
16spermatid nucleus differentiation (GO:0007289)5.78045754
17calcium ion-dependent exocytosis (GO:0017156)5.57012141
18negative regulation of inclusion body assembly (GO:0090084)5.55578237
19* spermatogenesis (GO:0007283)5.51148288
20* male gamete generation (GO:0048232)5.48938237
21organic cation transport (GO:0015695)5.47956840
22cell recognition (GO:0008037)5.41738380
23ventricular system development (GO:0021591)5.30916537
24behavioral response to nicotine (GO:0035095)5.19173191
25* gamete generation (GO:0007276)5.06086995
26cellular process involved in reproduction in multicellular organism (GO:0022412)4.98702024
27germ cell development (GO:0007281)4.78179394
28DNA deamination (GO:0045006)4.76814835
29regulation of inclusion body assembly (GO:0090083)4.62410919
30L-fucose catabolic process (GO:0042355)4.50501125
31fucose catabolic process (GO:0019317)4.50501125
32L-fucose metabolic process (GO:0042354)4.50501125
33DNA methylation involved in gamete generation (GO:0043046)4.38208555
34regulation of microtubule-based movement (GO:0060632)4.37241137
35response to pheromone (GO:0019236)4.35064873
36glycerol ether metabolic process (GO:0006662)4.27263347
37chromosome organization involved in meiosis (GO:0070192)4.21654002
38tryptophan catabolic process (GO:0006569)4.18388894
39indole-containing compound catabolic process (GO:0042436)4.18388894
40indolalkylamine catabolic process (GO:0046218)4.18388894
41male meiosis I (GO:0007141)4.14527638
42* multicellular organismal reproductive process (GO:0048609)3.97243273
43meiotic nuclear division (GO:0007126)3.96971768
44ether metabolic process (GO:0018904)3.94800328
45microtubule severing (GO:0051013)3.86454106
46centriole assembly (GO:0098534)3.85689431
47cellular ketone body metabolic process (GO:0046950)3.80226700
48kynurenine metabolic process (GO:0070189)3.72975576
49indolalkylamine metabolic process (GO:0006586)3.72644102
50tryptophan metabolic process (GO:0006568)3.70928956
51chaperone-mediated protein complex assembly (GO:0051131)3.67747863
52monoubiquitinated protein deubiquitination (GO:0035520)3.65326377
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.59257483
54centriole replication (GO:0007099)3.55973439
55water-soluble vitamin biosynthetic process (GO:0042364)3.51681949
56microtubule polymerization or depolymerization (GO:0031109)3.51406689
57cytidine deamination (GO:0009972)3.51283778
58cytidine metabolic process (GO:0046087)3.51283778
59cytidine catabolic process (GO:0006216)3.51283778
60regulation of memory T cell differentiation (GO:0043380)3.49981520
61left/right pattern formation (GO:0060972)3.47343674
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37479405
63protein localization to cilium (GO:0061512)3.36827893
64ketone body metabolic process (GO:1902224)3.35656852
65protein K11-linked deubiquitination (GO:0035871)3.32079785
66multicellular organismal development (GO:0007275)3.29267641
67detection of light stimulus involved in visual perception (GO:0050908)3.29156637
68detection of light stimulus involved in sensory perception (GO:0050962)3.29156637
69regulation of action potential (GO:0098900)3.24166726
70meiosis I (GO:0007127)3.23569076
71single strand break repair (GO:0000012)3.14632685
72chromosome condensation (GO:0030261)3.10533661
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.08448090
74alditol metabolic process (GO:0019400)3.06977936
75polyol catabolic process (GO:0046174)3.06160005
76cilium organization (GO:0044782)3.03645563
77seminiferous tubule development (GO:0072520)3.02836099
78platelet dense granule organization (GO:0060155)3.01963711
79amine catabolic process (GO:0009310)3.01083972
80cellular biogenic amine catabolic process (GO:0042402)3.01083972
81cilium assembly (GO:0042384)2.97807782
82negative regulation of mast cell activation (GO:0033004)2.97473344
83genitalia morphogenesis (GO:0035112)2.97240380
84sexual reproduction (GO:0019953)2.95763574
85cellular component assembly involved in morphogenesis (GO:0010927)2.94411423
86indole-containing compound metabolic process (GO:0042430)2.93823265
87negative regulation of telomere maintenance (GO:0032205)2.93472552
88amino-acid betaine transport (GO:0015838)2.92710102
89carnitine transport (GO:0015879)2.92710102
90respiratory chain complex IV assembly (GO:0008535)2.92616297
91microtubule-based movement (GO:0007018)2.92265309
92DNA packaging (GO:0006323)2.91583201
93cilium morphogenesis (GO:0060271)2.91226423
94protein polyglutamylation (GO:0018095)2.90439730
95positive regulation of defense response to virus by host (GO:0002230)2.89458795
96peptidyl-threonine dephosphorylation (GO:0035970)2.87311309
97nucleoside diphosphate phosphorylation (GO:0006165)2.86553769
98gamma-aminobutyric acid transport (GO:0015812)2.85086478
99intraciliary transport (GO:0042073)2.84710839
100glycerol metabolic process (GO:0006071)2.84301631
101protein complex biogenesis (GO:0070271)2.80588886
102neuronal action potential (GO:0019228)2.77841387
103meiotic cell cycle (GO:0051321)2.76883157
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76164144
105mannosylation (GO:0097502)2.75307454
106carnitine transmembrane transport (GO:1902603)2.74327441
107dopamine transport (GO:0015872)2.73907407
108axoneme assembly (GO:0035082)2.73519751
109adaptation of signaling pathway (GO:0023058)2.72764232
110GTP biosynthetic process (GO:0006183)2.71835431
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69984376
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.69984376
113NADH dehydrogenase complex assembly (GO:0010257)2.69984376
114NAD biosynthetic process (GO:0009435)2.69691568
115primary amino compound metabolic process (GO:1901160)2.69673908
116synapsis (GO:0007129)2.68458809
117rRNA catabolic process (GO:0016075)2.68446138
118kidney morphogenesis (GO:0060993)2.67248609
119transmission of nerve impulse (GO:0019226)2.66992398
120synaptic transmission, cholinergic (GO:0007271)2.66681462
121auditory receptor cell stereocilium organization (GO:0060088)2.63864252
122mitochondrial respiratory chain complex assembly (GO:0033108)2.63415124
123single-organism membrane fusion (GO:0044801)2.62232048
124positive regulation of macrophage activation (GO:0043032)2.59588179
125preassembly of GPI anchor in ER membrane (GO:0016254)2.59550089
126negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59211725
127lactate metabolic process (GO:0006089)2.59132640
128regulation of spindle checkpoint (GO:0090231)2.59103288
129regulation of centriole replication (GO:0046599)2.58282928
130retinal cone cell development (GO:0046549)2.57909957
131positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.57592602
132nonmotile primary cilium assembly (GO:0035058)2.57558497
133regulation of meiosis I (GO:0060631)2.54043252
134cytochrome complex assembly (GO:0017004)2.51415760
135positive regulation of meiosis (GO:0045836)2.51244267
136regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51170011
137glycolytic process (GO:0006096)2.50106393
138neural tube formation (GO:0001841)2.49765618
139sex differentiation (GO:0007548)2.49331309
140reflex (GO:0060004)2.48601177
141nucleus organization (GO:0006997)2.48552271
142regulation of neurotransmitter uptake (GO:0051580)2.47379522
143photoreceptor cell maintenance (GO:0045494)2.46467397
144cAMP catabolic process (GO:0006198)2.46447004
145negative regulation of organelle assembly (GO:1902116)2.45034092
146establishment of protein localization to Golgi (GO:0072600)2.44427423
147macroautophagy (GO:0016236)2.43062246
148rhodopsin mediated signaling pathway (GO:0016056)2.41941562
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41628566
150aromatic amino acid family catabolic process (GO:0009074)2.41538362
151photoreceptor cell development (GO:0042461)2.41533063
152positive regulation of meiotic cell cycle (GO:0051446)2.37369785
153sulfation (GO:0051923)2.36889492
154UTP biosynthetic process (GO:0006228)2.36869233
155protein refolding (GO:0042026)2.36006522
156DNA double-strand break processing (GO:0000729)2.35870716
157DNA demethylation (GO:0080111)2.35281576
158regulation of cytokine production involved in inflammatory response (GO:1900015)2.34937241
159signal peptide processing (GO:0006465)2.34670252
160meiotic cell cycle process (GO:1903046)2.33521694
161left/right axis specification (GO:0070986)2.28907426
162gene silencing by RNA (GO:0031047)2.28695223
163cell wall macromolecule catabolic process (GO:0016998)17.3302075
164cell wall macromolecule metabolic process (GO:0044036)17.3302075
165fusion of sperm to egg plasma membrane (GO:0007342)16.3538985
166multicellular organism reproduction (GO:0032504)13.1624246
167plasma membrane fusion (GO:0045026)12.5073271
168acrosome assembly (GO:0001675)12.2698403
169cilium or flagellum-dependent cell motility (GO:0001539)12.2385448
170sperm-egg recognition (GO:0035036)11.7961464
171sperm motility (GO:0030317)11.6939459
172reproduction (GO:0000003)10.8946937
173acrosome reaction (GO:0007340)10.6396801
174cell-cell recognition (GO:0009988)10.5576092
175axonemal dynein complex assembly (GO:0070286)10.0297619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.30703691
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.21110794
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90815456
4EZH2_22144423_ChIP-Seq_EOC_Human3.42501813
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71818202
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69889197
7GBX2_23144817_ChIP-Seq_PC3_Human2.58288425
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.50098870
9* CBX2_27304074_Chip-Seq_ESCs_Mouse2.49417380
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45332386
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38212185
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29943616
13IGF1R_20145208_ChIP-Seq_DFB_Human2.26528641
14ZNF274_21170338_ChIP-Seq_K562_Hela2.21937503
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21904294
16VDR_22108803_ChIP-Seq_LS180_Human2.15454815
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.07836331
18P300_19829295_ChIP-Seq_ESCs_Human2.00450138
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96758749
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96334446
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.95073655
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92898841
23TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.92480151
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82966249
25* KDM2B_26808549_Chip-Seq_REH_Human1.80140024
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.79700776
27* TAL1_26923725_Chip-Seq_HPCs_Mouse1.79314789
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77085374
29EWS_26573619_Chip-Seq_HEK293_Human1.75185726
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73381408
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72058224
32* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70504241
33TAF15_26573619_Chip-Seq_HEK293_Human1.70422846
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69501778
35GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.68085947
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67935573
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67776664
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67586473
39BCAT_22108803_ChIP-Seq_LS180_Human1.66829665
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66068445
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.65838496
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.64091071
43STAT1_17558387_ChIP-Seq_HELA_Human1.62868062
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57205135
45TP53_22573176_ChIP-Seq_HFKS_Human1.56317135
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.55395657
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.52276841
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51952777
49FLI1_21867929_ChIP-Seq_TH2_Mouse1.51611102
50AR_25329375_ChIP-Seq_VCAP_Human1.48689924
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.47764323
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.47355226
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.46796101
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.45196971
55IRF1_19129219_ChIP-ChIP_H3396_Human1.44062169
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44010095
57* STAT3_23295773_ChIP-Seq_U87_Human1.42612409
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.42571448
59P53_22387025_ChIP-Seq_ESCs_Mouse1.42418094
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41739862
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.40975658
62NANOG_19829295_ChIP-Seq_ESCs_Human1.40887693
63SOX2_19829295_ChIP-Seq_ESCs_Human1.40887693
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40674808
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.40674808
66* REST_21632747_ChIP-Seq_MESCs_Mouse1.40443718
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40172373
68* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39502785
69P300_18555785_Chip-Seq_ESCs_Mouse1.39105817
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39088312
71CBP_20019798_ChIP-Seq_JUKART_Human1.37766911
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37766911
73* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36913691
74* TCF4_23295773_ChIP-Seq_U87_Human1.36863439
75RNF2_27304074_Chip-Seq_NSC_Mouse1.35053562
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.34444796
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33982984
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33479375
79KLF4_18555785_Chip-Seq_ESCs_Mouse1.33417196
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.32924487
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32728480
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.32511094
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32038849
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31963631
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.31790117
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31643170
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30353189
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.30177719
89TCF4_22108803_ChIP-Seq_LS180_Human1.30008261
90GATA3_21867929_ChIP-Seq_CD8_Mouse1.29922269
91FUS_26573619_Chip-Seq_HEK293_Human1.29744538
92NCOR_22424771_ChIP-Seq_293T_Human1.28757247
93ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28519904
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28023649
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.26840973
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26558127
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24967897
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23629076
99MYC_18940864_ChIP-ChIP_HL60_Human1.22861178
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.22848009
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22713572
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.22588909
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22528038
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.21974890
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21233536
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.21077137
107SOX2_22085726_ChIP-Seq_NPCs_Mouse1.20884207
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.19797779
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.19007383
110* GF1_26923725_Chip-Seq_HPCs_Mouse1.17022871
111AR_20517297_ChIP-Seq_VCAP_Human1.16524245
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16440860
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15749036
114PU1_27457419_Chip-Seq_LIVER_Mouse1.14094668
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13773663
116* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12984453
117MYC_19829295_ChIP-Seq_ESCs_Human1.12523563
118ERA_21632823_ChIP-Seq_H3396_Human1.11320501
119HOXB7_26014856_ChIP-Seq_BT474_Human1.11153432
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.10643686
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10390747
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09062986
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08213554
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07099802
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07099802
126NANOG_20526341_ChIP-Seq_ESCs_Human1.06851471
127CDX2_22108803_ChIP-Seq_LS180_Human1.06164965
128ZFX_18555785_Chip-Seq_ESCs_Mouse1.06063350
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05872638
130TAF2_19829295_ChIP-Seq_ESCs_Human1.05105842
131ER_23166858_ChIP-Seq_MCF-7_Human1.05053432
132SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04827087
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04470339
134AR_21572438_ChIP-Seq_LNCaP_Human1.03792972
135SOX9_26525672_Chip-Seq_HEART_Mouse1.03718162
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03015452
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02729547
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01145879
139RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01118355
140AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01037741
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00869246
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99917760
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.99912707
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99864605
145GATA3_26560356_Chip-Seq_TH2_Human0.99354926
146TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99168368
147ETV1_20927104_ChIP-Seq_GIST48_Human0.98167649
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97983828
149* GF1B_26923725_Chip-Seq_HPCs_Mouse0.97751815
150KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97194469
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97101935
152P53_21459846_ChIP-Seq_SAOS-2_Human0.96651772
153* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95936413
154SMAD4_21799915_ChIP-Seq_A2780_Human0.94559032
155NFYB_21822215_ChIP-Seq_K562_Human0.94206247
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93570504
157STAT3_18555785_ChIP-Seq_MESCs_Mouse0.93248319
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92508330
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91998354
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.91906769
161RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91763419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.95363008
2MP0001929_abnormal_gametogenesis5.27180419
3MP0008877_abnormal_DNA_methylation4.53065154
4MP0002210_abnormal_sex_determination3.39362476
5MP0002161_abnormal_fertility/fecundity3.18622271
6MP0002653_abnormal_ependyma_morphology3.17090667
7MP0000569_abnormal_digit_pigmentation2.89439727
8MP0001145_abnormal_male_reproductive2.87501302
9MP0003195_calcinosis2.79223322
10MP0000653_abnormal_sex_gland2.52217817
11MP0009046_muscle_twitch2.30639064
12MP0005623_abnormal_meninges_morphology2.26718223
13MP0005670_abnormal_white_adipose2.21728848
14MP0005646_abnormal_pituitary_gland2.20551593
15MP0002138_abnormal_hepatobiliary_system2.13903912
16MP0005410_abnormal_fertilization15.3785259
17MP0002876_abnormal_thyroid_physiology1.97171732
18MP0004233_abnormal_muscle_weight1.92183021
19MP0004885_abnormal_endolymph1.84537583
20MP0006292_abnormal_olfactory_placode1.83174157
21MP0001501_abnormal_sleep_pattern1.75127026
22MP0002102_abnormal_ear_morphology1.70145046
23MP0003136_yellow_coat_color1.68884358
24MP0001984_abnormal_olfaction1.63824828
25MP0004043_abnormal_pH_regulation1.61620660
26MP0005645_abnormal_hypothalamus_physiol1.57398102
27MP0000372_irregular_coat_pigmentation1.56940952
28MP0001986_abnormal_taste_sensitivity1.53828535
29MP0001485_abnormal_pinna_reflex1.50515770
30MP0002638_abnormal_pupillary_reflex1.47423207
31MP0005671_abnormal_response_to1.46453260
32MP0004147_increased_porphyrin_level1.45876469
33MP0005084_abnormal_gallbladder_morpholo1.43060369
34MP0005379_endocrine/exocrine_gland_phen1.40310161
35MP0002234_abnormal_pharynx_morphology1.39202011
36MP0005174_abnormal_tail_pigmentation1.37955225
37MP0002163_abnormal_gland_morphology1.37873097
38MP0003787_abnormal_imprinting1.37268727
39MP0000427_abnormal_hair_cycle1.31814730
40MP0002733_abnormal_thermal_nociception1.29719313
41MP0003718_maternal_effect1.25353332
42MP0002282_abnormal_trachea_morphology1.24130409
43MP0000631_abnormal_neuroendocrine_gland1.23849345
44MP0001873_stomach_inflammation1.18564094
45MP0001970_abnormal_pain_threshold1.16457546
46MP0002160_abnormal_reproductive_system1.16177422
47MP0001765_abnormal_ion_homeostasis1.15218548
48MP0001905_abnormal_dopamine_level1.13080569
49MP0002938_white_spotting1.12911099
50MP0001919_abnormal_reproductive_system1.09433176
51MP0002277_abnormal_respiratory_mucosa1.07965527
52MP0006276_abnormal_autonomic_nervous1.07266461
53MP0002693_abnormal_pancreas_physiology0.99291621
54MP0010386_abnormal_urinary_bladder0.99062377
55MP0005085_abnormal_gallbladder_physiolo0.97534685
56MP0005075_abnormal_melanosome_morpholog0.94479080
57MP0005551_abnormal_eye_electrophysiolog0.92237336
58MP0003646_muscle_fatigue0.91883927
59MP0003252_abnormal_bile_duct0.88757120
60MP0002095_abnormal_skin_pigmentation0.87859858
61MP0005310_abnormal_salivary_gland0.87674026
62MP0000685_abnormal_immune_system0.87284151
63MP0005647_abnormal_sex_gland0.86627070
64MP0008058_abnormal_DNA_repair0.85147735
65MP0000230_abnormal_systemic_arterial0.82504432
66MP0000383_abnormal_hair_follicle0.82312826
67MP0004924_abnormal_behavior0.78729321
68MP0005386_behavior/neurological_phenoty0.78729321
69MP0003137_abnormal_impulse_conducting0.78302789
70MP0005167_abnormal_blood-brain_barrier0.77813781
71MP0002751_abnormal_autonomic_nervous0.77522763
72MP0005409_darkened_coat_color0.77134121
73MP0005332_abnormal_amino_acid0.75913115
74MP0003880_abnormal_central_pattern0.75324631
75MP0002837_dystrophic_cardiac_calcinosis0.75077434
76MP0008995_early_reproductive_senescence0.72481195
77MP0002928_abnormal_bile_duct0.67865552
78MP0001968_abnormal_touch/_nociception0.66449845
79MP0002736_abnormal_nociception_after0.62387630
80MP0002269_muscular_atrophy0.61956799
81MP0005535_abnormal_body_temperature0.60597733
82MP0001529_abnormal_vocalization0.60596293
83MP0002971_abnormal_brown_adipose0.60585480
84MP0003635_abnormal_synaptic_transmissio0.60149999
85MP0005636_abnormal_mineral_homeostasis0.58058256
86MP0003329_amyloid_beta_deposits0.57567606
87MP0004742_abnormal_vestibular_system0.56509141
88MP0001324_abnormal_eye_pigmentation0.55640920
89MP0001440_abnormal_grooming_behavior0.54509088
90MP0004145_abnormal_muscle_electrophysio0.53940793
91MP0003950_abnormal_plasma_membrane0.53033353
92MP0002572_abnormal_emotion/affect_behav0.52869095
93MP0002064_seizures0.52792359
94MP0003011_delayed_dark_adaptation0.52617751
95MP0005253_abnormal_eye_physiology0.52493750
96MP0002557_abnormal_social/conspecific_i0.52381432
97MP0004270_analgesia0.52376068
98MP0008057_abnormal_DNA_replication0.51285451
99MP0009745_abnormal_behavioral_response0.51123752
100MP0004036_abnormal_muscle_relaxation0.51021893
101MP0003633_abnormal_nervous_system0.50129761
102MP0005389_reproductive_system_phenotype0.48449109
103MP0003890_abnormal_embryonic-extraembry0.47599422
104MP0004133_heterotaxia0.45878727
105MP0002272_abnormal_nervous_system0.44740729
106MP0003699_abnormal_female_reproductive0.44364401
107MP0001486_abnormal_startle_reflex0.43575123
108MP0002152_abnormal_brain_morphology0.43430555
109MP0002063_abnormal_learning/memory/cond0.43233857
110MP0008569_lethality_at_weaning0.41169728
111MP0003115_abnormal_respiratory_system0.40018106
112MP0002752_abnormal_somatic_nervous0.39789939
113MP0003959_abnormal_lean_body0.39732793
114MP0005451_abnormal_body_composition0.38882756
115MP0003631_nervous_system_phenotype0.38146022
116MP0002735_abnormal_chemical_nociception0.37217647
117MP0000026_abnormal_inner_ear0.36937400
118MP0003283_abnormal_digestive_organ0.36113908
119MP0002229_neurodegeneration0.35828642
120MP0003861_abnormal_nervous_system0.34352607
121MP0002734_abnormal_mechanical_nocicepti0.34136612
122MP0005195_abnormal_posterior_eye0.34019906
123MP0002882_abnormal_neuron_morphology0.33965402
124MP0008872_abnormal_physiological_respon0.33957095
125MP0008961_abnormal_basal_metabolism0.33885498
126MP0004811_abnormal_neuron_physiology0.33775684
127MP0001963_abnormal_hearing_physiology0.33387570
128MP0001119_abnormal_female_reproductive0.32792906
129MP0000955_abnormal_spinal_cord0.32237333
130MP0000920_abnormal_myelination0.31769794
131MP0005377_hearing/vestibular/ear_phenot0.30885389
132MP0003878_abnormal_ear_physiology0.30885389
133MP0000604_amyloidosis0.30510121
134MP0002139_abnormal_hepatobiliary_system0.30317283
135MP0005423_abnormal_somatic_nervous0.28964297
136MP0009115_abnormal_fat_cell0.28560066
137MP0005391_vision/eye_phenotype0.28469311
138MP0002067_abnormal_sensory_capabilities0.28184165
139MP0002066_abnormal_motor_capabilities/c0.27058249
140MP0004019_abnormal_vitamin_homeostasis0.26892931
141MP0004859_abnormal_synaptic_plasticity0.26533192
142MP0000778_abnormal_nervous_system0.26173523
143MP0008875_abnormal_xenobiotic_pharmacok0.24969703
144MP0004134_abnormal_chest_morphology0.24652468
145MP0006072_abnormal_retinal_apoptosis0.24427384
146MP0001293_anophthalmia0.24190840
147MP0010094_abnormal_chromosome_stability0.24005931
148MP0004142_abnormal_muscle_tone0.23770093
149MP0006036_abnormal_mitochondrial_physio0.23077673

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.46035014
2Abnormal respiratory motile cilium morphology (HP:0005938)9.44219005
3Abnormal respiratory epithelium morphology (HP:0012253)9.44219005
4Abnormal ciliary motility (HP:0012262)8.10636522
5Rhinitis (HP:0012384)7.79849453
6Chronic bronchitis (HP:0004469)6.85338551
7Nasal polyposis (HP:0100582)6.07051824
8Infertility (HP:0000789)5.66841011
9Abnormality of the nasal mucosa (HP:0000433)4.94906189
10Bronchiectasis (HP:0002110)4.44555690
11Congenital stationary night blindness (HP:0007642)4.35823228
12Bronchitis (HP:0012387)4.20055455
13Pancreatic cysts (HP:0001737)4.09136958
14Medial flaring of the eyebrow (HP:0010747)3.88756560
15Nephronophthisis (HP:0000090)3.56647101
16Recurrent sinusitis (HP:0011108)3.50931678
17Male infertility (HP:0003251)3.47087880
18True hermaphroditism (HP:0010459)3.30234567
19Gait imbalance (HP:0002141)3.25001842
20Attenuation of retinal blood vessels (HP:0007843)3.22035722
21Congenital primary aphakia (HP:0007707)3.20441122
22Pendular nystagmus (HP:0012043)3.17887248
23Abnormal spermatogenesis (HP:0008669)3.12779246
24Recurrent otitis media (HP:0000403)3.00978274
25Abnormal rod and cone electroretinograms (HP:0008323)2.99634022
26Abnormality of the renal medulla (HP:0100957)2.77802382
27Nephrogenic diabetes insipidus (HP:0009806)2.76517276
28Abolished electroretinogram (ERG) (HP:0000550)2.75889280
29Progressive cerebellar ataxia (HP:0002073)2.67350049
30Chronic hepatic failure (HP:0100626)2.66590136
31Chronic sinusitis (HP:0011109)2.62607097
32Gaze-evoked nystagmus (HP:0000640)2.55476984
33Vaginal atresia (HP:0000148)2.53044214
34Genital tract atresia (HP:0001827)2.50640573
35Azoospermia (HP:0000027)2.50402712
36Hyperventilation (HP:0002883)2.49137008
37Genetic anticipation (HP:0003743)2.47362891
38Inability to walk (HP:0002540)2.43592051
39Recurrent bronchitis (HP:0002837)2.43200057
40Severe visual impairment (HP:0001141)2.42480712
41Tongue fasciculations (HP:0001308)2.40443563
42Abnormality of midbrain morphology (HP:0002418)2.38328802
43Molar tooth sign on MRI (HP:0002419)2.38328802
44Poor coordination (HP:0002370)2.37472786
45Large for gestational age (HP:0001520)2.37104063
46Tubulointerstitial nephritis (HP:0001970)2.37060751
47Aplasia/hypoplasia of the uterus (HP:0008684)2.36787108
48Increased corneal curvature (HP:0100692)2.31915009
49Keratoconus (HP:0000563)2.31915009
50Lissencephaly (HP:0001339)2.31557575
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29913585
52Cystic liver disease (HP:0006706)2.28926131
53Congenital, generalized hypertrichosis (HP:0004540)2.28571116
54Muscle fibrillation (HP:0010546)2.25669748
553-Methylglutaconic aciduria (HP:0003535)2.23993181
56Polyuria (HP:0000103)2.22943322
57Tubulointerstitial abnormality (HP:0001969)2.19900050
58Bony spicule pigmentary retinopathy (HP:0007737)2.16893473
59Stomatitis (HP:0010280)2.16209122
60Congenital sensorineural hearing impairment (HP:0008527)2.15799464
61Aplasia/Hypoplasia of the lens (HP:0008063)2.15679717
62Febrile seizures (HP:0002373)2.15188605
63Methylmalonic acidemia (HP:0002912)2.13571407
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12389457
65Tubular atrophy (HP:0000092)2.12136048
66Progressive inability to walk (HP:0002505)2.09947670
67Mitochondrial inheritance (HP:0001427)2.09362593
68Hypothermia (HP:0002045)2.08265725
69Abnormality of alanine metabolism (HP:0010916)2.08016747
70Hyperalaninemia (HP:0003348)2.08016747
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08016747
72Sclerocornea (HP:0000647)2.07624251
73Acute necrotizing encephalopathy (HP:0006965)2.07061618
74Abnormality of macular pigmentation (HP:0008002)2.05856355
75Renal cortical cysts (HP:0000803)2.04269019
76Impulsivity (HP:0100710)2.02397551
77Bile duct proliferation (HP:0001408)2.02070209
78Abnormal biliary tract physiology (HP:0012439)2.02070209
79Increased CSF lactate (HP:0002490)2.00649729
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1933478
81Dynein arm defect of respiratory motile cilia (HP:0012255)12.8918991
82Absent/shortened dynein arms (HP:0200106)12.8918991
83Decreased circulating renin level (HP:0003351)1.99072899
84Hypoproteinemia (HP:0003075)1.98884822
85Ketosis (HP:0001946)1.97474915
86Concave nail (HP:0001598)1.97348854
87Abnormality of saccadic eye movements (HP:0000570)1.97233136
88Hypoplasia of the uterus (HP:0000013)1.95350239
89Optic disc pallor (HP:0000543)1.94090651
90Furrowed tongue (HP:0000221)1.93524382
91Ketoacidosis (HP:0001993)1.91944571
92Acute encephalopathy (HP:0006846)1.91743652
93Methylmalonic aciduria (HP:0012120)1.91031103
94Focal motor seizures (HP:0011153)1.91020382
95Stomach cancer (HP:0012126)1.90376645
96IgG deficiency (HP:0004315)1.90057159
97Chorioretinal atrophy (HP:0000533)1.89556029
98Tubulointerstitial fibrosis (HP:0005576)1.88960919
99Lipid accumulation in hepatocytes (HP:0006561)1.87961969
100Severe muscular hypotonia (HP:0006829)1.86974279
101Thyroiditis (HP:0100646)1.85219142
102Progressive macrocephaly (HP:0004481)1.84443037
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.84239940
104Hypoplasia of the fovea (HP:0007750)1.84239940
105Abnormal urine output (HP:0012590)1.83235292
106Pachygyria (HP:0001302)1.82644873
107Male pseudohermaphroditism (HP:0000037)1.82269275
108Cerebellar dysplasia (HP:0007033)1.81986583
109Postaxial hand polydactyly (HP:0001162)1.81783594
110Agitation (HP:0000713)1.80342457
111Gonadotropin excess (HP:0000837)1.77782041
112Anencephaly (HP:0002323)1.77102458
113Postaxial foot polydactyly (HP:0001830)1.76831287
114Absent speech (HP:0001344)1.76407242
115Focal seizures (HP:0007359)1.75966603
116Facial cleft (HP:0002006)1.72792560
117Dialeptic seizures (HP:0011146)1.72207041
118Impaired smooth pursuit (HP:0007772)1.71669655
119Slow saccadic eye movements (HP:0000514)1.70990111
120Abnormality of the prostate (HP:0008775)1.70461299
121Prostate neoplasm (HP:0100787)1.69810641
122Stage 5 chronic kidney disease (HP:0003774)1.67347857
123Optic nerve hypoplasia (HP:0000609)1.67336095
124Congenital hepatic fibrosis (HP:0002612)1.67224292
125Abnormality of ocular smooth pursuit (HP:0000617)1.59980305
126Decreased central vision (HP:0007663)1.57573536
127Microglossia (HP:0000171)1.55553081
128Renal dysplasia (HP:0000110)1.52103166
129Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.50498722
130Heterotopia (HP:0002282)1.49913849
131Abnormality of the renal cortex (HP:0011035)1.48664307
132Supernumerary spleens (HP:0009799)1.48268837
133Spastic tetraparesis (HP:0001285)1.47522172
134Broad foot (HP:0001769)1.46877550
135Neurofibrillary tangles (HP:0002185)1.45757589
136Short ribs (HP:0000773)1.44536435
137Type II lissencephaly (HP:0007260)1.43951240
138Pancreatic fibrosis (HP:0100732)1.43505682
139Sensory axonal neuropathy (HP:0003390)1.40934396
140Abnormality of renal excretion (HP:0011036)1.39375167
141Easy fatigability (HP:0003388)1.38749498
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.38481770
143Fatigable weakness (HP:0003473)1.37522572
144Abnormality of the neuromuscular junction (HP:0003398)1.37522572
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.36257116
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.36199890
147Absent eyebrow (HP:0002223)1.36069218
148Type 2 muscle fiber atrophy (HP:0003554)1.35698421
149Toxemia of pregnancy (HP:0100603)1.35566322
150Renovascular hypertension (HP:0100817)1.35104242
151Chronic otitis media (HP:0000389)1.34425302
152Limb ataxia (HP:0002070)1.32803165
153Retinal dysplasia (HP:0007973)1.32646780
154Bundle branch block (HP:0011710)1.32199962
155Retinal atrophy (HP:0001105)1.32118109
156Papillary thyroid carcinoma (HP:0002895)1.30267549
157Dental crowding (HP:0000678)1.29848159
158Abnormal drinking behavior (HP:0030082)1.29396706
159Polydipsia (HP:0001959)1.29396706
160Hemiparesis (HP:0001269)1.28945892
161Nonprogressive disorder (HP:0003680)1.28438114
162Dyschromatopsia (HP:0007641)1.28055876
163Abnormality of permanent molar morphology (HP:0011071)1.27954459
164Abnormality of the dental root (HP:0006486)1.27954459
165Taurodontia (HP:0000679)1.27954459
166Median cleft lip (HP:0000161)1.24855882
167Poor suck (HP:0002033)1.24393585
168Specific learning disability (HP:0001328)1.24355523
169Cholecystitis (HP:0001082)1.23605805
170Abnormal gallbladder physiology (HP:0012438)1.23605805
171Hyporeflexia of lower limbs (HP:0002600)1.22886291
172Oculomotor apraxia (HP:0000657)1.22731993
173Abnormality of molar (HP:0011077)1.22592265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.83991417
2PDK48.83991417
3PDK25.72526257
4FRK4.78732932
5TESK14.10442690
6BMPR1B3.63545966
7PRKD33.45568648
8ICK3.32837498
9ADRBK23.25770918
10ZAK2.85060312
11STK392.84210187
12TXK2.72210126
13INSRR2.65167477
14NUAK12.50697471
15WNK42.48237973
16MAP4K22.47219013
17ACVR1B2.46911372
18PNCK2.43353614
19TLK12.40169154
20PTK2B2.20181505
21TAOK32.13187143
22WNK32.07014503
23TRIM281.43591013
24TGFBR11.32982568
25MAPK131.31523541
26PLK21.29566003
27DAPK21.28187744
28STK381.26667595
29RIPK41.26516663
30LMTK21.26146430
31PLK41.24512136
32DYRK21.11847523
33MKNK21.11779898
34PDK11.10122936
35IRAK11.08601645
36DYRK1B1.07106268
37BCKDK1.04847964
38CDK121.02826367
39VRK11.01461884
40ADRBK11.01095689
41PAK30.98348647
42WNK10.98138039
43TYRO30.94849718
44NEK20.94559939
45MST40.93402508
46PRKCE0.91221320
47PHKG10.86126626
48PHKG20.86126626
49IKBKB0.84830064
50MUSK0.84508122
51CDK190.83348652
52ITK0.82931775
53CAMKK20.82393205
54CSNK1G20.82325579
55CHEK20.78341433
56TEC0.74829202
57MAP2K70.73969375
58TNK20.72255374
59CSNK1G30.69818464
60PKN10.69673348
61RPS6KA50.69621765
62VRK20.69134626
63BCR0.68814097
64MAPKAPK30.68109370
65CSNK1G10.67485266
66NTRK30.67337815
67YES10.63177520
68CAMK1G0.60737005
69CCNB10.60619997
70PDPK10.58792163
71PIK3CA0.58720816
72SIK20.58631798
73MAPK150.58395788
74WEE10.58280962
75KIT0.55908428
76MAP3K40.54071624
77BRSK20.51312201
78SYK0.50379624
79CAMK10.49243705
80CSNK1A10.49029048
81FGFR20.48582359
82ERBB30.48565748
83STK38L0.47552690
84CSNK1A1L0.47076391
85TESK20.46781505
86TIE10.45017903
87STK30.42808156
88RIPK10.42323350
89MAP2K60.41732223
90NLK0.40253033
91EIF2AK30.40197800
92NME10.40181741
93CHEK10.40006959
94PLK30.39957014
95DYRK30.39269696
96CHUK0.36861226
97OXSR10.36753030
98PASK0.36082723
99PRKCG0.36011223
100LYN0.35269725
101GRK50.35072251
102NTRK20.35071089
103MKNK10.34588098
104EPHA40.34234500
105FLT30.33654076
106NEK60.33127424
107MAP4K10.32794041
108STK160.32083631
109TTK0.31527317
110PIK3CG0.30400758
111PRKCQ0.28585001
112PAK10.27618328
113MAPKAPK50.27381377
114AKT30.26891071
115IRAK20.25360474
116MARK10.25274461
117ATM0.25248561
118MARK30.25099050
119PBK0.24555505
120EPHB10.24533683
121PRKG10.24432182
122CAMK2A0.22316813
123TNIK0.19216272
124BRSK10.17172512
125CASK0.16012145
126CDK150.15277866
127STK110.13493011
128PAK20.12800725
129CSNK1D0.12735044
130EGFR0.12412381
131PRKCZ0.12296129
132CDK180.12230082
133PLK10.11793696
134BRAF0.10991946
135PDGFRB0.10770255
136FES0.10652118
137MINK10.10493108
138PRKG20.10048137
139PRKACG0.09969573
140CSNK2A20.09929654
141ATR0.09557307
142MAP2K40.09552910
143CDK30.09529871
144MARK20.09221049
145CDK11A0.09192261
146PRKACA0.08875081
147MAP3K60.08718746
148GSK3B0.08033544
149CDK140.07829676
150PRKCB0.07681652
151PRKAA10.07320955
152CAMKK10.07309334
153MTOR0.07070376
154PRKCA0.06456593
155CDK50.06252257
156CSNK2A10.06228829
157GRK70.05814419
158BMPR20.04927342
159FER0.04426491
160PINK10.04412720
161RPS6KB10.04121000
162PRKACB0.02963077
163GRK10.02258611

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.88645942
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.84565945
3Fatty acid biosynthesis_Homo sapiens_hsa000613.51306138
4Pyruvate metabolism_Homo sapiens_hsa006203.36082034
5Propanoate metabolism_Homo sapiens_hsa006403.26173255
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.97243144
7Phototransduction_Homo sapiens_hsa047442.69946715
8Butanoate metabolism_Homo sapiens_hsa006502.64327648
9Basal transcription factors_Homo sapiens_hsa030222.56851390
10Nitrogen metabolism_Homo sapiens_hsa009102.45558203
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.40417097
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40276878
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38119963
14Linoleic acid metabolism_Homo sapiens_hsa005912.35578151
15Pentose phosphate pathway_Homo sapiens_hsa000302.33509505
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33466999
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.27691186
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25679712
19Glucagon signaling pathway_Homo sapiens_hsa049222.24689140
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18139992
21Selenocompound metabolism_Homo sapiens_hsa004502.17477193
22Glycerolipid metabolism_Homo sapiens_hsa005612.07459989
23Huntingtons disease_Homo sapiens_hsa050161.99718921
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.96188798
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96081876
26Cardiac muscle contraction_Homo sapiens_hsa042601.79925932
27Oocyte meiosis_Homo sapiens_hsa041141.79389940
28Caffeine metabolism_Homo sapiens_hsa002321.78185454
29Asthma_Homo sapiens_hsa053101.77418406
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76098630
31Protein export_Homo sapiens_hsa030601.73711082
32PPAR signaling pathway_Homo sapiens_hsa033201.71010463
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67414746
34Autoimmune thyroid disease_Homo sapiens_hsa053201.65987604
35Tryptophan metabolism_Homo sapiens_hsa003801.64883425
36Allograft rejection_Homo sapiens_hsa053301.64195361
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63287159
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.58324190
39Primary immunodeficiency_Homo sapiens_hsa053401.56811036
40RNA polymerase_Homo sapiens_hsa030201.55929903
41Type I diabetes mellitus_Homo sapiens_hsa049401.53876320
42Fanconi anemia pathway_Homo sapiens_hsa034601.49795298
43Amphetamine addiction_Homo sapiens_hsa050311.45249575
44Homologous recombination_Homo sapiens_hsa034401.44255105
45Ether lipid metabolism_Homo sapiens_hsa005651.43506606
46Mineral absorption_Homo sapiens_hsa049781.42481608
47Parkinsons disease_Homo sapiens_hsa050121.41313835
48Graft-versus-host disease_Homo sapiens_hsa053321.41119684
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38981761
50Dorso-ventral axis formation_Homo sapiens_hsa043201.38527535
51Carbon metabolism_Homo sapiens_hsa012001.35901767
52Collecting duct acid secretion_Homo sapiens_hsa049661.32743612
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32065057
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30179505
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29440633
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28906140
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28635074
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.26063204
59Renin secretion_Homo sapiens_hsa049241.25986159
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18012664
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17824684
62Fatty acid metabolism_Homo sapiens_hsa012121.12452420
63Synaptic vesicle cycle_Homo sapiens_hsa047211.09871762
64Peroxisome_Homo sapiens_hsa041461.08192613
65Retinol metabolism_Homo sapiens_hsa008301.05070896
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04666562
67Renin-angiotensin system_Homo sapiens_hsa046141.03219494
68N-Glycan biosynthesis_Homo sapiens_hsa005101.00289032
69Proteasome_Homo sapiens_hsa030501.00010228
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.99504161
71Taste transduction_Homo sapiens_hsa047420.98909273
72Calcium signaling pathway_Homo sapiens_hsa040200.98541250
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95892781
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95735143
75Insulin secretion_Homo sapiens_hsa049110.94791454
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94558749
77Regulation of autophagy_Homo sapiens_hsa041400.91687876
78Purine metabolism_Homo sapiens_hsa002300.90698068
79Fat digestion and absorption_Homo sapiens_hsa049750.90009324
80Long-term potentiation_Homo sapiens_hsa047200.87489247
81Fatty acid degradation_Homo sapiens_hsa000710.87436028
82RNA degradation_Homo sapiens_hsa030180.87145314
83Biosynthesis of amino acids_Homo sapiens_hsa012300.86584469
84Glutathione metabolism_Homo sapiens_hsa004800.86300660
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83097335
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82710450
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79812793
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79514331
89Serotonergic synapse_Homo sapiens_hsa047260.78631776
90Estrogen signaling pathway_Homo sapiens_hsa049150.77339779
91GABAergic synapse_Homo sapiens_hsa047270.77232356
92Rheumatoid arthritis_Homo sapiens_hsa053230.77056239
93Fructose and mannose metabolism_Homo sapiens_hsa000510.76412046
94Bile secretion_Homo sapiens_hsa049760.72607518
95ABC transporters_Homo sapiens_hsa020100.72322936
96Circadian entrainment_Homo sapiens_hsa047130.71951949
97Nicotine addiction_Homo sapiens_hsa050330.71646594
98Salivary secretion_Homo sapiens_hsa049700.70761412
99One carbon pool by folate_Homo sapiens_hsa006700.70492707
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70373579
101Ovarian steroidogenesis_Homo sapiens_hsa049130.70329077
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68857033
103Thyroid hormone synthesis_Homo sapiens_hsa049180.68770055
104Chemical carcinogenesis_Homo sapiens_hsa052040.67992314
105Inositol phosphate metabolism_Homo sapiens_hsa005620.67120477
106Sulfur metabolism_Homo sapiens_hsa009200.66079132
107beta-Alanine metabolism_Homo sapiens_hsa004100.63608157
108Hematopoietic cell lineage_Homo sapiens_hsa046400.63565452
109Glutamatergic synapse_Homo sapiens_hsa047240.63389899
110Gastric acid secretion_Homo sapiens_hsa049710.62775804
111Protein digestion and absorption_Homo sapiens_hsa049740.62162802
112Pancreatic secretion_Homo sapiens_hsa049720.58683078
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58546384
114Antigen processing and presentation_Homo sapiens_hsa046120.55358789
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55021333
116mRNA surveillance pathway_Homo sapiens_hsa030150.51891106
117* Metabolic pathways_Homo sapiens_hsa011000.51877683
118Arachidonic acid metabolism_Homo sapiens_hsa005900.49609913
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49424894
120cAMP signaling pathway_Homo sapiens_hsa040240.48315182
121Pyrimidine metabolism_Homo sapiens_hsa002400.44855079
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44754504
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44044227
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42048689
125Hedgehog signaling pathway_Homo sapiens_hsa043400.41924325
126Oxidative phosphorylation_Homo sapiens_hsa001900.41449028
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.41231882
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40783828
129Morphine addiction_Homo sapiens_hsa050320.40335654
130Systemic lupus erythematosus_Homo sapiens_hsa053220.39713765
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.39108825
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39006187
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38690653
134Histidine metabolism_Homo sapiens_hsa003400.38623905
135RNA transport_Homo sapiens_hsa030130.38424715
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36389595
137Circadian rhythm_Homo sapiens_hsa047100.34377543
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34212428
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.33805577
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.33750057
141Cocaine addiction_Homo sapiens_hsa050300.33603422
142Vitamin digestion and absorption_Homo sapiens_hsa049770.33052035
143Olfactory transduction_Homo sapiens_hsa047400.32388357
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30173724
145Alzheimers disease_Homo sapiens_hsa050100.30134994
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25936028
147Steroid biosynthesis_Homo sapiens_hsa001000.25017821
148Dopaminergic synapse_Homo sapiens_hsa047280.24338094
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23815663
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22478555
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21884271
152Endocytosis_Homo sapiens_hsa041440.20208584
153Fatty acid elongation_Homo sapiens_hsa000620.15412724

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