ADAM17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.27637978
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.27637978
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.27637978
4modulation by symbiont of host immune response (GO:0052553)6.27637978
5positive regulation by symbiont of host defense response (GO:0052509)6.27637978
6modulation by symbiont of host defense response (GO:0052031)6.27637978
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21054617
8neutrophil activation involved in immune response (GO:0002283)4.74432727
9response to peptidoglycan (GO:0032494)4.74382716
10regulation of interferon-beta biosynthetic process (GO:0045357)4.68653933
11positive regulation of interferon-alpha production (GO:0032727)4.37359410
12macrophage activation involved in immune response (GO:0002281)4.29569848
13regulation of interferon-alpha production (GO:0032647)4.17507960
14response to host immune response (GO:0052572)3.99424039
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99424039
16microglial cell activation (GO:0001774)3.98361869
17immunoglobulin mediated immune response (GO:0016064)3.93672902
18response to muramyl dipeptide (GO:0032495)3.87576675
19regulation of vitamin D biosynthetic process (GO:0060556)3.72725892
20positive regulation of gamma-delta T cell activation (GO:0046645)3.65955765
21positive regulation of antigen processing and presentation (GO:0002579)3.65735178
22response to host (GO:0075136)3.65682945
23response to host defenses (GO:0052200)3.65682945
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65682945
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63531820
26neutrophil activation (GO:0042119)3.57935340
27* response to lipoprotein particle (GO:0055094)3.56083381
28respiratory burst (GO:0045730)3.53520460
29granulocyte activation (GO:0036230)3.48201518
30positive regulation of interferon-beta production (GO:0032728)3.44088499
31natural killer cell mediated cytotoxicity (GO:0042267)3.36412959
32natural killer cell mediated immunity (GO:0002228)3.36412959
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35709293
34cellular response to ethanol (GO:0071361)3.28844909
35regulation of antigen processing and presentation (GO:0002577)3.22280250
36pinocytosis (GO:0006907)3.19728090
37myeloid cell activation involved in immune response (GO:0002275)3.16572006
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15918431
39macrophage activation (GO:0042116)3.13708455
40* cell adhesion mediated by integrin (GO:0033627)3.10626999
41I-kappaB phosphorylation (GO:0007252)3.09700834
42osteoclast differentiation (GO:0030316)3.09349071
43regulation of B cell receptor signaling pathway (GO:0050855)3.07151831
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06954657
45positive regulation of cellular amide metabolic process (GO:0034250)3.05962648
46negative regulation of interleukin-12 production (GO:0032695)3.04568001
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03479591
48regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.99181831
49superoxide anion generation (GO:0042554)2.96176059
50antigen processing and presentation of endogenous antigen (GO:0019883)2.94515941
51B cell mediated immunity (GO:0019724)2.93967636
52positive regulation of chemokine biosynthetic process (GO:0045080)2.89575774
53NIK/NF-kappaB signaling (GO:0038061)2.89494845
54cytokine secretion (GO:0050663)2.88821804
55detection of molecule of bacterial origin (GO:0032490)2.88642719
56regulation of mononuclear cell migration (GO:0071675)2.88379118
57response to type I interferon (GO:0034340)2.86959145
58cellular response to type I interferon (GO:0071357)2.86279044
59type I interferon signaling pathway (GO:0060337)2.86279044
60regulation of mast cell degranulation (GO:0043304)2.81574382
61positive regulation of interleukin-1 beta secretion (GO:0050718)2.81045112
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.80355368
63branching involved in labyrinthine layer morphogenesis (GO:0060670)2.79401441
64leukocyte aggregation (GO:0070486)2.79105606
65interferon-gamma-mediated signaling pathway (GO:0060333)2.78827083
66positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77527412
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75957675
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75957675
69leukocyte mediated cytotoxicity (GO:0001909)2.72288641
70cellular extravasation (GO:0045123)2.72261849
71regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70140596
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69711480
73regulation of interferon-beta production (GO:0032648)2.69086649
74interleukin-6-mediated signaling pathway (GO:0070102)2.67758603
75positive regulation of interleukin-12 production (GO:0032735)2.66822814
76protein localization to endosome (GO:0036010)2.66779942
77regulation of mast cell activation involved in immune response (GO:0033006)2.65522067
78positive regulation of B cell differentiation (GO:0045579)2.63986868
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.63694682
80negative regulation of interleukin-17 production (GO:0032700)2.62767055
81cellular response to interferon-beta (GO:0035458)2.62468557
82hydrogen peroxide biosynthetic process (GO:0050665)2.60861519
83regulation of interleukin-8 biosynthetic process (GO:0045414)2.60749863
84regulation of chronic inflammatory response (GO:0002676)2.60501369
85positive regulation of interleukin-1 secretion (GO:0050716)2.59715660
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58546881
87cellular response to interferon-alpha (GO:0035457)2.57784175
88myeloid leukocyte activation (GO:0002274)2.57437199
89positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.57026741
90response to interferon-alpha (GO:0035455)2.56967005
91regulation of vitamin metabolic process (GO:0030656)2.56074718
92regulation of mast cell activation (GO:0033003)2.55996946
93negative regulation of lipid storage (GO:0010888)2.53817220
94positive regulation of NF-kappaB import into nucleus (GO:0042346)2.53667406
95positive regulation of heat generation (GO:0031652)2.53275926
96modulation by symbiont of host cellular process (GO:0044068)2.52933706
97* neutrophil mediated immunity (GO:0002446)2.49429103
98negative regulation of mast cell activation (GO:0033004)2.49328519
99positive regulation vascular endothelial growth factor production (GO:0010575)2.49172378
100regulation of interleukin-1 beta secretion (GO:0050706)2.47146957
101lymphocyte mediated immunity (GO:0002449)2.46798270
102positive regulation of mast cell activation (GO:0033005)2.46509645
103positive regulation of leukocyte degranulation (GO:0043302)2.46192487
104leukocyte cell-cell adhesion (GO:0007159)2.45860106
105regulation of fever generation (GO:0031620)2.45715916
106myeloid dendritic cell activation (GO:0001773)2.45474425
107T cell migration (GO:0072678)2.45189146
108cellular response to exogenous dsRNA (GO:0071360)2.44814572
109regulation of interleukin-12 production (GO:0032655)2.44663148
110B cell homeostasis (GO:0001782)2.44454398
111regulation of cholesterol storage (GO:0010885)2.43318004
112regulation of vascular endothelial growth factor production (GO:0010574)2.43075455
113cellular response to virus (GO:0098586)2.42897561
114negative regulation of B cell proliferation (GO:0030889)2.42257769
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41775813
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41767747
117nuclear pore complex assembly (GO:0051292)2.41452561
118regulation of RIG-I signaling pathway (GO:0039535)2.41084638
119pore complex assembly (GO:0046931)2.40641606
120production of molecular mediator involved in inflammatory response (GO:0002532)2.40451262
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39803025
122regulation of NF-kappaB import into nucleus (GO:0042345)2.38695393
123positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.38038624
124positive regulation of interleukin-6 production (GO:0032755)2.37773153
125necroptotic process (GO:0070266)2.36948027
126platelet-derived growth factor receptor signaling pathway (GO:0048008)2.33951215
127nuclear pore organization (GO:0006999)2.32320520
128regulation of T-helper 1 cell differentiation (GO:0045625)2.31124386
129iron ion import (GO:0097286)2.30817311
130mRNA transcription (GO:0009299)2.30578282
131negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.24859894
132positive regulation of interleukin-1 production (GO:0032732)2.23506166
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.23307714
134cytoplasmic mRNA processing body assembly (GO:0033962)2.22134020
135* regulation of lymphocyte chemotaxis (GO:1901623)2.22055618
136eosinophil chemotaxis (GO:0048245)2.21631032
137interferon-gamma secretion (GO:0072643)2.21047358
138nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.20970699
139positive regulation of macrophage differentiation (GO:0045651)2.20297022
140positive regulation of interleukin-1 beta production (GO:0032731)2.17899191
141positive regulation of monocyte chemotaxis (GO:0090026)2.17552005
142substrate-dependent cell migration (GO:0006929)2.15897870
143hemidesmosome assembly (GO:0031581)2.15240313
144cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.15054939
145hepatocyte apoptotic process (GO:0097284)2.15019485
146regulation of heat generation (GO:0031650)2.13744548
147cellular response to molecule of bacterial origin (GO:0071219)2.13497908
148regulation of membrane protein ectodomain proteolysis (GO:0051043)2.13099424
149regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.12681859
150positive regulation of nitric oxide biosynthetic process (GO:0045429)2.12455461
151mammary gland epithelial cell proliferation (GO:0033598)2.11159885
152sphingosine metabolic process (GO:0006670)2.10032534
153nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.09775017
154positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.09568860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.02426860
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.59810105
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.72571629
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14313767
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.03859480
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75726624
7E2F7_22180533_ChIP-Seq_HELA_Human3.57389652
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49740164
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33734989
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.29912531
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16063885
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13957049
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94618545
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87616975
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78791408
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74347883
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73036764
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.71932009
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63696204
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.59840242
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57794564
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.24718484
23SPI1_23547873_ChIP-Seq_NB4_Human2.20723953
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17747204
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09227040
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01637902
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93086958
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92231588
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.90282964
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86327176
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84553392
32SCL_19346495_ChIP-Seq_HPC-7_Human1.81227280
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79912340
34MYB_26560356_Chip-Seq_TH2_Human1.77186856
35PU_27001747_Chip-Seq_BMDM_Mouse1.74186111
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.70758445
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67742946
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67593698
39RUNX_20019798_ChIP-Seq_JUKART_Human1.66199413
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65322667
41VDR_24763502_ChIP-Seq_THP-1_Human1.64713507
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64539936
43TP53_16413492_ChIP-PET_HCT116_Human1.60554994
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60046335
45MYB_26560356_Chip-Seq_TH1_Human1.58485881
46* RUNX1_22412390_ChIP-Seq_EML_Mouse1.58145051
47VDR_24787735_ChIP-Seq_THP-1_Human1.53713401
48* MAF_26560356_Chip-Seq_TH1_Human1.48652275
49AHR_22903824_ChIP-Seq_MCF-7_Human1.47449645
50SPI1_23127762_ChIP-Seq_K562_Human1.46882013
51VDR_21846776_ChIP-Seq_THP-1_Human1.45878879
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44796965
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42674930
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42674930
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41337633
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39576584
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34262324
58TP63_23658742_ChIP-Seq_EP156T_Human1.32507378
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32463602
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30222724
61GATA1_22025678_ChIP-Seq_K562_Human1.28751310
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28680726
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.28538829
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26168496
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21863269
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21540270
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21540270
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20892780
69TP53_18474530_ChIP-ChIP_U2OS_Human1.20767954
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19149536
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17686482
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16555292
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15525086
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14985216
75TAF15_26573619_Chip-Seq_HEK293_Human1.14139492
76IGF1R_20145208_ChIP-Seq_DFB_Human1.13634473
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13609164
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.13366940
79GATA3_27048872_Chip-Seq_THYMUS_Human1.12887240
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12530421
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12157564
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12126981
83GATA3_26560356_Chip-Seq_TH2_Human1.09655418
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09413134
85UTX_26944678_Chip-Seq_JUKART_Human1.08665770
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.08546963
87TFEB_21752829_ChIP-Seq_HELA_Human1.08518375
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08117068
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07768604
90* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07396481
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05734205
92* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05423208
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05111059
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04384160
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.04270976
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03975745
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.03922799
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03076851
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02671824
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.01983905
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01149128
102* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00686063
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99371039
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98821868
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98755843
106* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98017074
107* ELK1_19687146_ChIP-ChIP_HELA_Human0.97717964
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.96464835
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96047991
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95737105
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95686951
112ER_23166858_ChIP-Seq_MCF-7_Human0.95392953
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.95296855
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94012095
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.93996763
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.93915707
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93698023
118GBX2_23144817_ChIP-Seq_PC3_Human0.93091514
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91118526
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89269583
121TCF7_22412390_ChIP-Seq_EML_Mouse0.88130969
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.88029765
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87804977
124* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87573135
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.86301033
126AR_21909140_ChIP-Seq_LNCAP_Human0.85929154
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.84751563
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.82905800
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80903382
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79977573
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79657960
132* CJUN_26792858_Chip-Seq_BT549_Human0.79353484
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78397182
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77850946
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77727350
136CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77370178
137MYC_22102868_ChIP-Seq_BL_Human0.76859088
138MAF_26560356_Chip-Seq_TH2_Human0.76545270
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75953185
140* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75700135
141BRD4_25478319_ChIP-Seq_HGPS_Human0.75699746
142* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74105910
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73694814
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71440412
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71409203
146ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71125841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.78972412
2MP0003436_decreased_susceptibility_to2.98454747
3MP0002877_abnormal_melanocyte_morpholog2.85897108
4* MP0002419_abnormal_innate_immunity2.72680889
5MP0009785_altered_susceptibility_to2.71049396
6MP0005000_abnormal_immune_tolerance2.67459173
7MP0005058_abnormal_lysosome_morphology2.66944063
8MP0006082_CNS_inflammation2.66402800
9MP0002148_abnormal_hypersensitivity_rea2.63698652
10MP0003303_peritoneal_inflammation2.57467085
11MP0001790_abnormal_immune_system2.46121313
12MP0005387_immune_system_phenotype2.46121313
13* MP0002452_abnormal_antigen_presenting2.40439019
14MP0005025_abnormal_response_to2.35077471
15MP0001800_abnormal_humoral_immune2.34173195
16MP0000685_abnormal_immune_system2.33157638
17MP0002009_preneoplasia2.32126747
18MP0010234_abnormal_vibrissa_follicle2.26014720
19MP0003724_increased_susceptibility_to2.22302997
20MP0005671_abnormal_response_to2.18502507
21* MP0002723_abnormal_immune_serum2.17853607
22* MP0001819_abnormal_immune_cell2.00065240
23* MP0002420_abnormal_adaptive_immunity1.98180341
24MP0000569_abnormal_digit_pigmentation1.93609384
25MP0009278_abnormal_bone_marrow1.91268228
26* MP0010678_abnormal_skin_adnexa1.90030623
27MP0003448_altered_tumor_morphology1.89108516
28MP0003656_abnormal_erythrocyte_physiolo1.83308952
29MP0001533_abnormal_skeleton_physiology1.77111717
30* MP0004947_skin_inflammation1.75843279
31MP0008438_abnormal_cutaneous_collagen1.72997606
32MP0002405_respiratory_system_inflammati1.69998912
33MP0003300_gastrointestinal_ulcer1.68999172
34MP0001853_heart_inflammation1.68362857
35MP0003172_abnormal_lysosome_physiology1.65096783
36* MP0005464_abnormal_platelet_physiology1.63539457
37MP0001545_abnormal_hematopoietic_system1.55783176
38MP0005397_hematopoietic_system_phenotyp1.55783176
39* MP0000383_abnormal_hair_follicle1.54303367
40MP0002006_tumorigenesis1.50809056
41* MP0001845_abnormal_inflammatory_respons1.49843675
42MP0010307_abnormal_tumor_latency1.49740330
43* MP0000716_abnormal_immune_system1.48457249
44MP0002166_altered_tumor_susceptibility1.45716187
45MP0004510_myositis1.45542658
46* MP0002398_abnormal_bone_marrow1.44055848
47MP0009333_abnormal_splenocyte_physiolog1.41914196
48MP0003221_abnormal_cardiomyocyte_apopto1.37679932
49MP0002396_abnormal_hematopoietic_system1.36026781
50MP0000343_altered_response_to1.35675408
51MP0003566_abnormal_cell_adhesion1.35033539
52* MP0010155_abnormal_intestine_physiology1.32115380
53MP0005076_abnormal_cell_differentiation1.31161912
54MP0000858_altered_metastatic_potential1.31032112
55* MP0000689_abnormal_spleen_morphology1.30602350
56MP0009764_decreased_sensitivity_to1.28054316
57MP0004883_abnormal_blood_vessel1.26610589
58MP0009840_abnormal_foam_cell1.25623609
59* MP0008469_abnormal_protein_level1.25620911
60MP0003453_abnormal_keratinocyte_physiol1.24538709
61MP0003828_pulmonary_edema1.23785802
62MP0000465_gastrointestinal_hemorrhage1.22885573
63* MP0002429_abnormal_blood_cell1.21418005
64MP0003191_abnormal_cellular_cholesterol1.20163252
65MP0002933_joint_inflammation1.19480528
66MP0002277_abnormal_respiratory_mucosa1.19411967
67* MP0002998_abnormal_bone_remodeling1.19151982
68MP0005248_abnormal_Harderian_gland1.18949517
69MP0005257_abnormal_intraocular_pressure1.18855891
70MP0005451_abnormal_body_composition1.18677788
71MP0001958_emphysema1.17670889
72MP0004272_abnormal_basement_membrane1.17614007
73* MP0002722_abnormal_immune_system1.17369522
74MP0005310_abnormal_salivary_gland1.17356580
75MP0010352_gastrointestinal_tract_polyps1.17264554
76MP0002332_abnormal_exercise_endurance1.17219577
77MP0004808_abnormal_hematopoietic_stem1.15502076
78MP0008260_abnormal_autophagy1.14788665
79MP0002138_abnormal_hepatobiliary_system1.14714295
80MP0001851_eye_inflammation1.10737069
81MP0001216_abnormal_epidermal_layer1.10704841
82MP0003763_abnormal_thymus_physiology1.08633042
83MP0000537_abnormal_urethra_morphology1.07217262
84MP0005174_abnormal_tail_pigmentation1.07176887
85MP0005390_skeleton_phenotype1.06565548
86MP0005023_abnormal_wound_healing1.05577114
87MP0003091_abnormal_cell_migration1.00465348
88MP0004782_abnormal_surfactant_physiolog0.99442153
89MP0008057_abnormal_DNA_replication0.98613461
90MP0002254_reproductive_system_inflammat0.97422051
91MP0002896_abnormal_bone_mineralization0.96954108
92MP0008004_abnormal_stomach_pH0.96832433
93MP0009765_abnormal_xenobiotic_induced0.94314403
94MP0003690_abnormal_glial_cell0.94077060
95MP0000427_abnormal_hair_cycle0.93799652
96MP0000767_abnormal_smooth_muscle0.91321088
97MP0005171_absent_coat_pigmentation0.91048703
98MP0000490_abnormal_crypts_of0.89324796
99MP0001727_abnormal_embryo_implantation0.88621214
100MP0003705_abnormal_hypodermis_morpholog0.86214466
101MP0000371_diluted_coat_color0.85720590
102MP0003136_yellow_coat_color0.85423217
103MP0000015_abnormal_ear_pigmentation0.85385297
104MP0005167_abnormal_blood-brain_barrier0.85357930
105MP0005409_darkened_coat_color0.85096209
106MP0001915_intracranial_hemorrhage0.84932939
107MP0009053_abnormal_anal_canal0.84899490
108MP0003075_altered_response_to0.84141147
109MP0002060_abnormal_skin_morphology0.83688001
110MP0001873_stomach_inflammation0.82740752
111MP0004185_abnormal_adipocyte_glucose0.81943841
112MP0005164_abnormal_response_to0.80188197
113MP0004381_abnormal_hair_follicle0.79943894
114MP0000604_amyloidosis0.79463963
115MP0005647_abnormal_sex_gland0.77451814
116MP0001849_ear_inflammation0.76668981
117MP0000703_abnormal_thymus_morphology0.76334154
118MP0003279_aneurysm0.75917399
119* MP0009763_increased_sensitivity_to0.75700992
120MP0008007_abnormal_cellular_replicative0.75487059
121MP0003950_abnormal_plasma_membrane0.74671597
122MP0003632_abnormal_nervous_system0.74333325
123MP0006054_spinal_hemorrhage0.73777320
124MP0003183_abnormal_peptide_metabolism0.73195358
125MP0000249_abnormal_blood_vessel0.73063968
126MP0000733_abnormal_muscle_development0.72610369
127MP0005166_decreased_susceptibility_to0.72033636
128MP0003329_amyloid_beta_deposits0.70008961
129MP0000516_abnormal_urinary_system0.69935432
130MP0005367_renal/urinary_system_phenotyp0.69935432
131MP0000428_abnormal_craniofacial_morphol0.68054162

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.49165694
2Recurrent bacterial skin infections (HP:0005406)5.87752397
3Eczematoid dermatitis (HP:0000976)5.64204854
4Abnormality of macrophages (HP:0004311)4.59215350
5Recurrent gram-negative bacterial infections (HP:0005420)4.33307104
6Mediastinal lymphadenopathy (HP:0100721)3.94831519
7Vacuolated lymphocytes (HP:0001922)3.90735144
8Elevated erythrocyte sedimentation rate (HP:0003565)3.89764535
9Increased cerebral lipofuscin (HP:0011813)3.80994493
10Autoimmune thrombocytopenia (HP:0001973)3.76021956
11Prostate neoplasm (HP:0100787)3.67673604
12Recurrent skin infections (HP:0001581)3.61964036
13Myositis (HP:0100614)3.61936352
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.59040680
15Chronic obstructive pulmonary disease (HP:0006510)3.58337692
16Obstructive lung disease (HP:0006536)3.58337692
17Subacute progressive viral hepatitis (HP:0006572)3.51148608
18Gingivitis (HP:0000230)3.50748314
19Stomatitis (HP:0010280)3.43632140
20Orchitis (HP:0100796)3.38544214
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.35232822
22Osteolytic defects of the hand bones (HP:0009699)3.35232822
23Recurrent fungal infections (HP:0002841)3.30569509
24Systemic lupus erythematosus (HP:0002725)3.26608513
25Optic neuritis (HP:0100653)3.25849425
26Retrobulbar optic neuritis (HP:0100654)3.25849425
27Abnormality of glycolipid metabolism (HP:0010969)2.99643089
28Abnormality of liposaccharide metabolism (HP:0010968)2.99643089
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.99643089
30Recurrent viral infections (HP:0004429)2.99387179
31Periodontitis (HP:0000704)2.97125805
32Vasculitis (HP:0002633)2.91195409
33Cellulitis (HP:0100658)2.91165301
34Bilateral sensorineural hearing impairment (HP:0008619)2.72436070
35Basal ganglia calcification (HP:0002135)2.65674914
36Osteomyelitis (HP:0002754)2.64068644
37Abnormality of the nasal septum (HP:0000419)2.62164692
38Disinhibition (HP:0000734)2.57275208
39Chronic otitis media (HP:0000389)2.54062842
40Recurrent pneumonia (HP:0006532)2.53934701
41Absent frontal sinuses (HP:0002688)2.52498129
42Myocardial infarction (HP:0001658)2.51096906
43Chronic mucocutaneous candidiasis (HP:0002728)2.45661435
44Recurrent cutaneous fungal infections (HP:0011370)2.45661435
45Axonal loss (HP:0003447)2.43749724
46Fused cervical vertebrae (HP:0002949)2.42744655
47Glomerulonephritis (HP:0000099)2.42727241
48Curly hair (HP:0002212)2.41724228
49Stenosis of the external auditory canal (HP:0000402)2.41214256
50Meningitis (HP:0001287)2.41023892
51Abnormality of the frontal sinuses (HP:0002687)2.40796517
52* Thick nail (HP:0001805)2.36489646
53Papillary thyroid carcinoma (HP:0002895)2.36404426
54Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.33993472
55Interstitial pulmonary disease (HP:0006530)2.33489161
56Abnormality of the distal phalanges of the toes (HP:0010182)2.32329753
57Pulmonary infiltrates (HP:0002113)2.32183789
58Dysostosis multiplex (HP:0000943)2.31696932
59Thyroid carcinoma (HP:0002890)2.30247230
60Agnosia (HP:0010524)2.26849174
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.26492467
62* Leukocytosis (HP:0001974)2.26356711
63* Pustule (HP:0200039)2.25419046
64Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.25285597
65Short 1st metacarpal (HP:0010034)2.25285597
66Recurrent lower respiratory tract infections (HP:0002783)2.21431941
67Premature loss of primary teeth (HP:0006323)2.21097207
68Abnormality of the prostate (HP:0008775)2.20547197
69Hepatosplenomegaly (HP:0001433)2.19453074
70Urticaria (HP:0001025)2.18931665
71Spontaneous hematomas (HP:0007420)2.18337930
72Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14744108
73Thyroiditis (HP:0100646)2.12751344
74Arterial thrombosis (HP:0004420)2.12495255
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11050680
76Transitional cell carcinoma of the bladder (HP:0006740)2.06946519
77Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.00957487
78Nephritis (HP:0000123)2.00418120
79Skin ulcer (HP:0200042)2.00252609
80Tetraparesis (HP:0002273)1.99833963
81Bladder neoplasm (HP:0009725)1.96914493
82Bladder carcinoma (HP:0002862)1.96914493
83Hemoptysis (HP:0002105)1.95066657
84Coarse hair (HP:0002208)1.94257393
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94222884
86Keratoconjunctivitis sicca (HP:0001097)1.94219282
87Neoplasm of the tracheobronchial system (HP:0100552)1.94132098
88Petechiae (HP:0000967)1.93932592
89Gingival bleeding (HP:0000225)1.92325725
90Keratitis (HP:0000491)1.91890534
91Neurofibrillary tangles (HP:0002185)1.91863004
92Emphysema (HP:0002097)1.91302988
93Cutaneous melanoma (HP:0012056)1.90418819
94Keratoconjunctivitis (HP:0001096)1.87674121
95Abnormality of oral frenula (HP:0000190)1.87341353
96Short humerus (HP:0005792)1.86462754
97Bone pain (HP:0002653)1.85601957
98Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84906866
99Abnormality of the 1st metacarpal (HP:0010009)1.82836691
100Viral hepatitis (HP:0006562)1.82662986
101Alveolar cell carcinoma (HP:0006519)1.82207249
102Restrictive lung disease (HP:0002091)1.82159163
103Abnormality of T cell number (HP:0011839)1.81187604
104Vertebral compression fractures (HP:0002953)1.79624953
105Aplasia/hypoplasia of the humerus (HP:0006507)1.78746907
106Stomach cancer (HP:0012126)1.78604269
107Colitis (HP:0002583)1.78480708
108Loss of speech (HP:0002371)1.77008250
109Inflammation of the large intestine (HP:0002037)1.73973900
110Premature rupture of membranes (HP:0001788)1.73951752
111Abnormality of B cell number (HP:0010975)1.72974074
112Spastic diplegia (HP:0001264)1.72703617
113Autoimmune hemolytic anemia (HP:0001890)1.72480054
114Dislocated radial head (HP:0003083)1.72215516
115Cheilitis (HP:0100825)1.71828247
116Increased IgM level (HP:0003496)1.71827474
117Pathologic fracture (HP:0002756)1.70930591
118Tibial bowing (HP:0002982)1.69839642
119Cone-rod dystrophy (HP:0000548)1.69505497
120Submucous cleft hard palate (HP:0000176)1.69379806
121Alopecia of scalp (HP:0002293)1.68957417
122Abnormality of the pleura (HP:0002103)1.68870818
123T lymphocytopenia (HP:0005403)1.68328062
124Leukopenia (HP:0001882)1.67978210
125Persistence of primary teeth (HP:0006335)1.67792496
126Spondylolisthesis (HP:0003302)1.67726138
127Urinary glycosaminoglycan excretion (HP:0003541)1.67642497
128Mucopolysacchariduria (HP:0008155)1.67642497
129Milia (HP:0001056)1.67362943
130Vitreoretinal degeneration (HP:0000655)1.67235853
131Poor head control (HP:0002421)1.66530424
132Albinism (HP:0001022)1.66518090
133Sepsis (HP:0100806)1.66341422
134Hypergammaglobulinemia (HP:0010702)1.65800321
135Amaurosis fugax (HP:0100576)1.65073705
136* Hematochezia (HP:0002573)1.64721057
137B lymphocytopenia (HP:0010976)1.64462336
138Syringomyelia (HP:0003396)1.64266308
139Spinal cord lesions (HP:0100561)1.64266308
140Adactyly (HP:0009776)1.64204358
141Chromsome breakage (HP:0040012)1.63469051
142Anhidrosis (HP:0000970)1.63428639
143Agammaglobulinemia (HP:0004432)1.63320060
144Peritonitis (HP:0002586)1.62990561
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62936662
146Somatic mutation (HP:0001428)1.61863602
147Chest pain (HP:0100749)1.61546916
148Arterial tortuosity (HP:0005116)1.61185240
149Ectopic kidney (HP:0000086)1.60696254
150Ankyloglossia (HP:0010296)1.60095273
151Ectropion (HP:0000656)1.59315576
152Abnormality of the radial head (HP:0003995)1.58635909
153Increased CSF protein (HP:0002922)1.58433008
154Cubitus valgus (HP:0002967)1.57189654
155Hypoalphalipoproteinemia (HP:0003233)1.56604093
156Deep philtrum (HP:0002002)1.54242574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.04690978
2IRAK43.57918514
3MAP3K143.53479227
4BLK3.20403344
5TYK22.84533942
6EIF2AK32.76639820
7TBK12.61173124
8MAP4K12.43159428
9BRD42.27014255
10TGFBR22.23123398
11ERBB32.21035518
12STK102.20735362
13KIT2.17822596
14JAK32.17712075
15IKBKB2.14155117
16RIPK42.13041580
17IKBKE2.03008067
18PBK1.93090848
19NEK91.92622993
20FER1.83564827
21ERBB41.82868408
22JAK11.70939124
23FRK1.70063897
24TXK1.69228811
25BCR1.57926945
26CSF1R1.52842049
27STK38L1.51504276
28KSR11.47935147
29RPS6KA41.46654977
30MARK31.42121677
31FLT31.40641230
32CHUK1.40584976
33SIK31.39135200
34STK31.36110321
35CSK1.34445898
36NTRK11.32740091
37ZAK1.32411936
38EPHB11.31628995
39CLK11.28784624
40ZAP701.24599902
41HCK1.20799982
42PIM11.18882208
43STK41.18389014
44PIM21.17266739
45TEC1.16712243
46PLK41.15839142
47TRPM71.15256726
48TAOK31.14657842
49MAP3K131.14489942
50TTN1.08387564
51BTK1.07815834
52ERN11.05946944
53EIF2AK21.05542178
54LYN1.04955612
55CDK121.04227990
56ITK0.95303382
57SYK0.95236796
58* LCK0.94145306
59NUAK10.93850355
60IRAK10.91440609
61BMPR1B0.90432037
62FGR0.85974919
63LRRK20.85418117
64CAMK1D0.85075363
65TIE10.84771516
66CSNK1A1L0.83765616
67STK390.83399818
68FGFR30.83252782
69NME20.82648644
70MAP2K30.81375096
71PDGFRA0.81208233
72MAP3K30.80888095
73MST40.79654513
74TRIM280.79653905
75IRAK20.77527872
76TGFBR10.77119948
77MET0.76573052
78MAP4K20.76560366
79SGK30.74668288
80MKNK10.74468090
81JAK20.74439744
82MELK0.72709235
83GRK70.71941374
84ABL10.71936995
85CDK60.71747132
86KDR0.69984002
87ERBB20.69970407
88PKN20.69856499
89FGFR40.66610030
90ACVR1B0.66434456
91AKT30.66343712
92TNIK0.66218918
93MATK0.63245645
94CAMKK20.62579358
95ADRBK20.62092360
96MKNK20.58469951
97LATS10.57683604
98PTK2B0.57483288
99BMX0.57435787
100INSR0.57097775
101MAP3K80.55900082
102YES10.54812232
103PDGFRB0.53907879
104MAP3K20.53693607
105MOS0.52795351
106NEK60.52739657
107EGFR0.52348322
108PAK40.52042089
109NEK20.51790488
110MAPKAPK20.51484714
111EPHA30.50514502
112CSNK1G20.50462076
113BRSK20.50250799
114LATS20.49075722
115RPS6KA50.48757325
116DDR20.48606182
117PTK60.48122835
118MAP3K100.47356079
119TTK0.47126704
120RIPK10.46906143
121CDK40.46444716
122CSNK1G10.45413102
123FES0.43270143
124SGK20.43015435
125MAP3K10.42419220
126STK240.41758105
127NLK0.41000876
128PRKCQ0.39595303
129EPHA20.39105387
130BMPR20.38503798
131ABL20.36899761
132* PRKCD0.35627081
133MST1R0.35421280
134ATR0.33398699
135CDK90.29804813
136IGF1R0.29427727
137MAP3K50.29302234
138BUB10.27890806
139CAMK1G0.27309069

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85999222
2Staphylococcus aureus infection_Homo sapiens_hsa051502.67395113
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.64005906
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39003958
5Osteoclast differentiation_Homo sapiens_hsa043802.23012335
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16004001
7Malaria_Homo sapiens_hsa051442.13455765
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11901096
9Graft-versus-host disease_Homo sapiens_hsa053322.06021932
10Measles_Homo sapiens_hsa051622.02195009
11Legionellosis_Homo sapiens_hsa051341.98107782
12Pertussis_Homo sapiens_hsa051331.94944017
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93001272
14Lysosome_Homo sapiens_hsa041421.90469527
15B cell receptor signaling pathway_Homo sapiens_hsa046621.79070272
16Tuberculosis_Homo sapiens_hsa051521.78424598
17Allograft rejection_Homo sapiens_hsa053301.76862258
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75734695
19Antigen processing and presentation_Homo sapiens_hsa046121.75134935
20Influenza A_Homo sapiens_hsa051641.68256631
21Hematopoietic cell lineage_Homo sapiens_hsa046401.67050846
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.65753525
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.64124698
24Toxoplasmosis_Homo sapiens_hsa051451.63492017
25Other glycan degradation_Homo sapiens_hsa005111.62467695
26Herpes simplex infection_Homo sapiens_hsa051681.62241924
27TNF signaling pathway_Homo sapiens_hsa046681.61407343
28Asthma_Homo sapiens_hsa053101.51458739
29Apoptosis_Homo sapiens_hsa042101.49840668
30Rheumatoid arthritis_Homo sapiens_hsa053231.47460171
31Phagosome_Homo sapiens_hsa041451.40698346
32Primary immunodeficiency_Homo sapiens_hsa053401.37284590
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34450594
34Dorso-ventral axis formation_Homo sapiens_hsa043201.33200194
35Salmonella infection_Homo sapiens_hsa051321.29654162
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29653551
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.26174853
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.25293327
39Shigellosis_Homo sapiens_hsa051311.25168703
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24435666
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23607136
42Viral myocarditis_Homo sapiens_hsa054161.23045533
43Hepatitis B_Homo sapiens_hsa051611.20940668
44Small cell lung cancer_Homo sapiens_hsa052221.20402051
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19470666
46Thyroid cancer_Homo sapiens_hsa052161.12337365
47Chemokine signaling pathway_Homo sapiens_hsa040621.09976626
48* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08920385
49Hepatitis C_Homo sapiens_hsa051601.06481389
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02932437
51Autoimmune thyroid disease_Homo sapiens_hsa053201.00380264
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99782591
53Epstein-Barr virus infection_Homo sapiens_hsa051690.98140250
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95982550
55Chronic myeloid leukemia_Homo sapiens_hsa052200.94054788
56Bladder cancer_Homo sapiens_hsa052190.93695829
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93579931
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92007473
59T cell receptor signaling pathway_Homo sapiens_hsa046600.91205505
60p53 signaling pathway_Homo sapiens_hsa041150.90024202
61Pancreatic cancer_Homo sapiens_hsa052120.88092673
62African trypanosomiasis_Homo sapiens_hsa051430.87343242
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86355298
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85896133
65Amoebiasis_Homo sapiens_hsa051460.84611675
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83651585
67Viral carcinogenesis_Homo sapiens_hsa052030.83206479
68Sphingolipid metabolism_Homo sapiens_hsa006000.81979738
69Acute myeloid leukemia_Homo sapiens_hsa052210.81435141
70MicroRNAs in cancer_Homo sapiens_hsa052060.79592249
71mTOR signaling pathway_Homo sapiens_hsa041500.70826769
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70022466
73ECM-receptor interaction_Homo sapiens_hsa045120.69539957
74HTLV-I infection_Homo sapiens_hsa051660.68313974
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65608033
76Proteoglycans in cancer_Homo sapiens_hsa052050.65287529
77Platelet activation_Homo sapiens_hsa046110.64384616
78Non-small cell lung cancer_Homo sapiens_hsa052230.61151198
79Sulfur metabolism_Homo sapiens_hsa009200.60529338
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60378962
81Endometrial cancer_Homo sapiens_hsa052130.59179671
82Type II diabetes mellitus_Homo sapiens_hsa049300.57729836
83Prostate cancer_Homo sapiens_hsa052150.56258465
84Adherens junction_Homo sapiens_hsa045200.55806702
85Melanoma_Homo sapiens_hsa052180.55507851
86Colorectal cancer_Homo sapiens_hsa052100.55316654
87Cell cycle_Homo sapiens_hsa041100.54975531
88Focal adhesion_Homo sapiens_hsa045100.53582906
89Type I diabetes mellitus_Homo sapiens_hsa049400.53375669
90ErbB signaling pathway_Homo sapiens_hsa040120.53078805
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51635304
92DNA replication_Homo sapiens_hsa030300.50451447
93Rap1 signaling pathway_Homo sapiens_hsa040150.50144320
94Steroid biosynthesis_Homo sapiens_hsa001000.49322757
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.49127198
96Complement and coagulation cascades_Homo sapiens_hsa046100.48935372
97Fanconi anemia pathway_Homo sapiens_hsa034600.48219296
98HIF-1 signaling pathway_Homo sapiens_hsa040660.48175092
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.47847931
100Glioma_Homo sapiens_hsa052140.47228223
101Systemic lupus erythematosus_Homo sapiens_hsa053220.45897972
102* Notch signaling pathway_Homo sapiens_hsa043300.44365474
103Renal cell carcinoma_Homo sapiens_hsa052110.41796327
104Prolactin signaling pathway_Homo sapiens_hsa049170.41701181
105FoxO signaling pathway_Homo sapiens_hsa040680.41574318
106Homologous recombination_Homo sapiens_hsa034400.41067160
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.40892827
108Pathways in cancer_Homo sapiens_hsa052000.38774905
109Endocytosis_Homo sapiens_hsa041440.37916672
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35521496
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35233311
112TGF-beta signaling pathway_Homo sapiens_hsa043500.35064825
113Renin-angiotensin system_Homo sapiens_hsa046140.34268729
114Base excision repair_Homo sapiens_hsa034100.34117952
115Non-homologous end-joining_Homo sapiens_hsa034500.33987056
116Arachidonic acid metabolism_Homo sapiens_hsa005900.33458452
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32302599
118Caffeine metabolism_Homo sapiens_hsa002320.32076744
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.32029472

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