ADAM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)4.75152995
2cellular response to ethanol (GO:0071361)4.02658468
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97511117
4hepatocyte apoptotic process (GO:0097284)3.89484367
5negative regulation of phagocytosis (GO:0050765)3.87660275
6retina vasculature morphogenesis in camera-type eye (GO:0061299)3.71879606
7megakaryocyte development (GO:0035855)3.62306799
8nuclear pore complex assembly (GO:0051292)3.61823455
9positive regulation of gamma-delta T cell activation (GO:0046645)3.59007150
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58808563
11germ cell migration (GO:0008354)3.50199995
12protein localization to endosome (GO:0036010)3.48851097
13angiogenesis involved in wound healing (GO:0060055)3.31745611
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.19839234
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18383301
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18383301
17glycoprotein catabolic process (GO:0006516)3.16316655
18production of molecular mediator involved in inflammatory response (GO:0002532)3.15229756
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14955352
20Rap protein signal transduction (GO:0032486)3.14778926
21endothelium development (GO:0003158)3.13875348
22antigen processing and presentation of endogenous antigen (GO:0019883)3.12749815
23monoubiquitinated protein deubiquitination (GO:0035520)3.12552247
24regulation of transforming growth factor beta2 production (GO:0032909)3.12168815
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.09198986
26modulation by symbiont of host immune response (GO:0052553)3.09198986
27positive regulation by symbiont of host defense response (GO:0052509)3.09198986
28modulation by symbiont of host defense response (GO:0052031)3.09198986
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09198986
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09198986
31iron ion import (GO:0097286)3.05836394
32regulation of B cell receptor signaling pathway (GO:0050855)3.04049564
33embryonic foregut morphogenesis (GO:0048617)3.02169872
34regulation of interferon-beta biosynthetic process (GO:0045357)2.97375027
35genitalia morphogenesis (GO:0035112)2.96739201
36sprouting angiogenesis (GO:0002040)2.96694302
37bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94577532
38nuclear pore organization (GO:0006999)2.91483294
39hypotonic response (GO:0006971)2.91464248
40pathway-restricted SMAD protein phosphorylation (GO:0060389)2.87764568
41mitotic sister chromatid cohesion (GO:0007064)2.86735551
42interleukin-6-mediated signaling pathway (GO:0070102)2.86441081
43neutrophil activation involved in immune response (GO:0002283)2.86101083
44positive regulation of interferon-alpha production (GO:0032727)2.85608133
45melanin biosynthetic process (GO:0042438)2.82895328
46positive regulation of B cell differentiation (GO:0045579)2.81544318
47platelet-derived growth factor receptor signaling pathway (GO:0048008)2.80492652
48pericardium development (GO:0060039)2.80434558
49phagocytosis, engulfment (GO:0006911)2.79757663
50regulation of Rac protein signal transduction (GO:0035020)2.78683653
51wound healing, spreading of epidermal cells (GO:0035313)2.76385261
52keratinocyte development (GO:0003334)2.74757801
53regulation of interleukin-12 biosynthetic process (GO:0045075)2.72396680
54cellular response to vitamin (GO:0071295)2.71471708
55regulation of interferon-alpha production (GO:0032647)2.70867387
56regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.69566876
57positive regulation of cell junction assembly (GO:1901890)2.69113783
58positive regulation of focal adhesion assembly (GO:0051894)2.69113783
59embryonic hemopoiesis (GO:0035162)2.67903634
60COPII vesicle coating (GO:0048208)2.67856264
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66388820
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66367332
63negative regulation of complement activation (GO:0045916)2.64566639
64positive regulation of macrophage differentiation (GO:0045651)2.63529904
65melanin metabolic process (GO:0006582)2.63326878
66membrane raft organization (GO:0031579)2.63040466
673-UTR-mediated mRNA stabilization (GO:0070935)2.62524770
68regulation of protein polyubiquitination (GO:1902914)2.61516682
69regulation of DNA endoreduplication (GO:0032875)2.61166951
70regulation of erythrocyte differentiation (GO:0045646)2.59288238
71negative regulation of DNA repair (GO:0045738)2.58055713
72glucocorticoid receptor signaling pathway (GO:0042921)2.57468374
73erythrocyte maturation (GO:0043249)2.57195959
74osteoclast differentiation (GO:0030316)2.56443622
75pore complex assembly (GO:0046931)2.56333040
76negative regulation of erythrocyte differentiation (GO:0045647)2.56072892
77thrombin receptor signaling pathway (GO:0070493)2.56061252
78phospholipid translocation (GO:0045332)2.54917929
79lipid translocation (GO:0034204)2.54917929
80protein targeting to vacuole (GO:0006623)2.54875328
81protein targeting to lysosome (GO:0006622)2.54875328
82establishment of protein localization to vacuole (GO:0072666)2.54875328
83negative regulation of fibroblast apoptotic process (GO:2000270)2.53383033
84labyrinthine layer development (GO:0060711)2.53288771
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52414821
86detection of molecule of bacterial origin (GO:0032490)2.51788047
87cytoplasmic mRNA processing body assembly (GO:0033962)2.51638887
88regulation of gamma-delta T cell differentiation (GO:0045586)2.50569068
89lymph vessel development (GO:0001945)2.50228414
90positive regulation of natural killer cell differentiation (GO:0032825)2.48989255
91glomerular visceral epithelial cell development (GO:0072015)2.47886317
92myeloid dendritic cell activation (GO:0001773)2.47869799
93positive regulation of protein autophosphorylation (GO:0031954)2.47384926
94cell adhesion mediated by integrin (GO:0033627)2.46801552
95protein localization to cell surface (GO:0034394)2.46719055
96sequestering of extracellular ligand from receptor (GO:0035581)2.46345192
97regulation of gamma-delta T cell activation (GO:0046643)2.45581894
98response to host (GO:0075136)2.44936008
99response to host defenses (GO:0052200)2.44936008
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44936008
101cellular extravasation (GO:0045123)2.44544744
102mesodermal cell differentiation (GO:0048333)2.43442355
103endodermal cell differentiation (GO:0035987)2.42547938
104negative regulation of protein autophosphorylation (GO:0031953)2.41666722
105corticosteroid receptor signaling pathway (GO:0031958)2.41511246
106SMAD protein complex assembly (GO:0007183)2.40369241
107immunoglobulin mediated immune response (GO:0016064)2.40244755
108histone-serine phosphorylation (GO:0035404)2.37975377
109regulation of fibroblast apoptotic process (GO:2000269)2.37816761
110macrophage activation involved in immune response (GO:0002281)2.37784117
111negative regulation of protein activation cascade (GO:2000258)2.36992753
112substrate-dependent cell migration (GO:0006929)2.36938531
113heparin biosynthetic process (GO:0030210)2.36813542
114heparin metabolic process (GO:0030202)2.36813542
115positive regulation of adherens junction organization (GO:1903393)2.35782581
116positive regulation of erythrocyte differentiation (GO:0045648)2.35708427
117leukocyte tethering or rolling (GO:0050901)2.35381192
118positive regulation of glycoprotein biosynthetic process (GO:0010560)2.34337937
119response to type I interferon (GO:0034340)2.33731023
120positive regulation of protein import into nucleus, translocation (GO:0033160)2.33182444
121vascular endothelial growth factor signaling pathway (GO:0038084)2.32156998
122Golgi to endosome transport (GO:0006895)2.31979303
123response to interferon-alpha (GO:0035455)2.31946719
124regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.30704211
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30600056
126morphogenesis of an endothelium (GO:0003159)2.30163734
127endothelial tube morphogenesis (GO:0061154)2.30163734
128patterning of blood vessels (GO:0001569)2.30114173
129chondrocyte development (GO:0002063)2.29770530
130regulation of transforming growth factor beta production (GO:0071634)2.29637948
131secondary metabolite biosynthetic process (GO:0044550)2.29605818
132embryonic process involved in female pregnancy (GO:0060136)2.29489362
133regulation of necroptotic process (GO:0060544)2.29457178
134negative regulation of B cell proliferation (GO:0030889)2.29306867
135regulation of transforming growth factor beta1 production (GO:0032908)2.29250983
136histone mRNA catabolic process (GO:0071044)2.27737242
137neutrophil activation (GO:0042119)2.27411493
138substrate adhesion-dependent cell spreading (GO:0034446)2.27013442
139cellular response to type I interferon (GO:0071357)2.27001769
140type I interferon signaling pathway (GO:0060337)2.27001769
141cellular response to vitamin D (GO:0071305)2.26707946
142regulation of B cell differentiation (GO:0045577)2.26613233
143response to muramyl dipeptide (GO:0032495)2.26343942
144chondrocyte proliferation (GO:0035988)2.25147866
145membrane invagination (GO:0010324)2.24720130
146blood vessel maturation (GO:0001955)2.24696388
147platelet dense granule organization (GO:0060155)2.24618899
148leukocyte cell-cell adhesion (GO:0007159)2.24615715
149positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.24491586
150gap junction assembly (GO:0016264)2.24414621
151early endosome to late endosome transport (GO:0045022)2.24177838
152natural killer cell differentiation (GO:0001779)2.24127060
153negative regulation of keratinocyte proliferation (GO:0010839)2.23846293
154negative regulation of thymocyte apoptotic process (GO:0070244)2.23710835
155mast cell activation (GO:0045576)2.23613233
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23588220
157response to host immune response (GO:0052572)2.23588220
158T cell homeostasis (GO:0043029)2.22657390
159hippo signaling (GO:0035329)2.22443461
160leukocyte aggregation (GO:0070486)2.22291191
161positive regulation of glycoprotein metabolic process (GO:1903020)2.21926206
162lymphocyte homeostasis (GO:0002260)2.20877735
163B cell receptor signaling pathway (GO:0050853)2.20487577
164necroptotic process (GO:0070266)2.20411767
165desmosome organization (GO:0002934)2.20257172
166establishment of endothelial barrier (GO:0061028)2.19947695
167actin nucleation (GO:0045010)2.19607302
168positive regulation of receptor recycling (GO:0001921)2.19537840
169positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.19406025
170myeloid cell development (GO:0061515)2.19243171
171positive regulation of chemokine secretion (GO:0090197)2.19170767
172positive regulation of epithelial to mesenchymal transition (GO:0010718)2.17762547
173positive regulation of cardiac muscle hypertrophy (GO:0010613)2.17663407
174positive regulation of muscle hypertrophy (GO:0014742)2.17663407
175negative regulation of protein localization to plasma membrane (GO:1903077)2.16784394
176negative regulation of chondrocyte differentiation (GO:0032331)2.16563888
177histamine secretion (GO:0001821)2.16140947
178basement membrane organization (GO:0071711)2.15742407
179positive regulation of SMAD protein import into nucleus (GO:0060391)2.15528960
180interferon-gamma-mediated signaling pathway (GO:0060333)2.14883709
181negative regulation of viral genome replication (GO:0045071)2.14719281
182positive regulation of vasculogenesis (GO:2001214)2.14551094
183dendritic cell chemotaxis (GO:0002407)2.13273414
184dendritic cell migration (GO:0036336)2.13160114
185secretory granule organization (GO:0033363)2.12231939
186response to interferon-beta (GO:0035456)2.10833576
187myeloid cell activation involved in immune response (GO:0002275)2.08828264
188pinocytosis (GO:0006907)2.08278198
189positive regulation of interferon-beta production (GO:0032728)2.05834448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76829352
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.81797274
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.63763584
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.77247815
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56398118
6SCL_19346495_ChIP-Seq_HPC-7_Human3.32118398
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.27401290
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14488413
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.09797760
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09625535
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.98428690
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87541195
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.80437352
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69105608
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65212026
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64443642
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54198981
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53731187
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50906916
20MYC_22102868_ChIP-Seq_BL_Human2.32844793
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26514302
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23554008
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15194844
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07173465
25MYB_26560356_Chip-Seq_TH2_Human2.06849534
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06142969
27ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05100261
28RUNX_20019798_ChIP-Seq_JUKART_Human2.02894822
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.00649205
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.98202441
31* SPI1_23547873_ChIP-Seq_NB4_Human1.86083337
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85644342
33* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84155793
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82291745
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80839382
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78274816
37MAF_26560356_Chip-Seq_TH1_Human1.76951998
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.76900082
39VDR_24763502_ChIP-Seq_THP-1_Human1.76647248
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73263661
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73263661
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.70727693
43GATA1_22025678_ChIP-Seq_K562_Human1.70442967
44MYB_26560356_Chip-Seq_TH1_Human1.69501968
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68916036
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66221174
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.65996524
48CJUN_26792858_Chip-Seq_BT549_Human1.65649845
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65346414
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.65164207
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63836857
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63600361
53VDR_21846776_ChIP-Seq_THP-1_Human1.59305166
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57552295
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57138356
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55091916
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.54173253
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52873006
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52559871
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49382684
61PU_27001747_Chip-Seq_BMDM_Mouse1.48771420
62UTX_26944678_Chip-Seq_JUKART_Human1.48745444
63CLOCK_20551151_ChIP-Seq_293T_Human1.48340116
64SPI1_23127762_ChIP-Seq_K562_Human1.47198606
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46853375
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44484420
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44484420
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43513470
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43316478
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.43149851
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.41465354
72AR_21909140_ChIP-Seq_LNCAP_Human1.39824504
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39499692
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39383875
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39280240
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.37995578
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36653937
78TP53_16413492_ChIP-PET_HCT116_Human1.36045744
79* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35614556
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35213460
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33158018
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.32490220
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32150874
84TP63_23658742_ChIP-Seq_EP156T_Human1.30930565
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.30717788
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30477787
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.29449300
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27294916
89GATA1_19941826_ChIP-Seq_K562_Human1.25815939
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25769527
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25611762
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24955431
93P300_19829295_ChIP-Seq_ESCs_Human1.24710486
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24557326
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23077442
96* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22836752
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22365444
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.20749106
99AHR_22903824_ChIP-Seq_MCF-7_Human1.20570498
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20242770
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.20237944
102VDR_24787735_ChIP-Seq_THP-1_Human1.19899503
103* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19598064
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19154143
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18691852
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18265711
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17914915
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17900188
109GATA3_27048872_Chip-Seq_THYMUS_Human1.16542584
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.16035864
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.14263868
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13297113
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12526536
114CDX2_22108803_ChIP-Seq_LS180_Human1.12408428
115* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12091611
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11011050
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10643367
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.10308299
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10159729
120TP53_18474530_ChIP-ChIP_U2OS_Human1.10030291
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09787338
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09615251
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09272674
124BRD4_25478319_ChIP-Seq_HGPS_Human1.08745117
125GATA2_19941826_ChIP-Seq_K562_Human1.08416388
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08320647
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08124831
128NCOR1_26117541_ChIP-Seq_K562_Human1.08041430
129* SMAD4_21799915_ChIP-Seq_A2780_Human1.06947852
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.06526363
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06473076
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06417673
133EWS_26573619_Chip-Seq_HEK293_Human1.05216920
134ESR1_20079471_ChIP-ChIP_T-47D_Human1.04758308
135WT1_19549856_ChIP-ChIP_CCG9911_Human1.03630601
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.03290686
137GBX2_23144817_ChIP-Seq_PC3_Human1.03031070
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02921115
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02728040
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.01864458
141P53_22387025_ChIP-Seq_ESCs_Mouse1.01725290
142SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01545292
143KDM2B_26808549_Chip-Seq_DND41_Human1.00757828
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00456992
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.99254179
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99188167
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98767154
148FUS_26573619_Chip-Seq_HEK293_Human0.98744223
149* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98447594
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98203797
151* ELK1_19687146_ChIP-ChIP_HELA_Human0.97882756
152LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97427511
153FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97262148
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96968863
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96934663
156* STAT3_23295773_ChIP-Seq_U87_Human0.96789510
157TAF15_26573619_Chip-Seq_HEK293_Human0.96428842
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96102693
159* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95607911
160* SOX2_20726797_ChIP-Seq_SW620_Human0.95530076
161EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95284530
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.93792079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.86743879
2MP0003300_gastrointestinal_ulcer2.78927238
3MP0001835_abnormal_antigen_presentation2.60577971
4MP0005397_hematopoietic_system_phenotyp2.56742359
5MP0001545_abnormal_hematopoietic_system2.56742359
6MP0002396_abnormal_hematopoietic_system2.54310981
7MP0009278_abnormal_bone_marrow2.49207817
8MP0005408_hypopigmentation2.46697495
9MP0004808_abnormal_hematopoietic_stem2.45691634
10MP0008057_abnormal_DNA_replication2.41776797
11MP0002166_altered_tumor_susceptibility2.19534678
12MP0001879_abnormal_lymphatic_vessel2.17985669
13MP0000015_abnormal_ear_pigmentation2.14712624
14MP0000465_gastrointestinal_hemorrhage2.14579062
15MP0003172_abnormal_lysosome_physiology2.10490362
16MP0003950_abnormal_plasma_membrane1.96429434
17MP0000372_irregular_coat_pigmentation1.94097104
18MP0010368_abnormal_lymphatic_system1.93021228
19MP0005075_abnormal_melanosome_morpholog1.91512230
20MP0003436_decreased_susceptibility_to1.90016269
21MP0008438_abnormal_cutaneous_collagen1.85084802
22MP0005257_abnormal_intraocular_pressure1.80748116
23MP0010234_abnormal_vibrissa_follicle1.80690733
24MP0010352_gastrointestinal_tract_polyps1.80131796
25MP0000371_diluted_coat_color1.78218622
26MP0003303_peritoneal_inflammation1.77721887
27MP0005671_abnormal_response_to1.76041517
28MP0003724_increased_susceptibility_to1.74135388
29MP0002006_tumorigenesis1.73357447
30MP0002419_abnormal_innate_immunity1.72393876
31MP0002877_abnormal_melanocyte_morpholog1.71889652
32MP0003941_abnormal_skin_development1.70053630
33MP0002452_abnormal_antigen_presenting1.68528883
34* MP0005464_abnormal_platelet_physiology1.68129864
35MP0004147_increased_porphyrin_level1.67754776
36MP0003279_aneurysm1.66874386
37MP0000685_abnormal_immune_system1.66535256
38MP0003890_abnormal_embryonic-extraembry1.65774592
39MP0009785_altered_susceptibility_to1.64078438
40MP0005000_abnormal_immune_tolerance1.62871295
41* MP0002398_abnormal_bone_marrow1.58918258
42MP0002148_abnormal_hypersensitivity_rea1.56908837
43MP0002420_abnormal_adaptive_immunity1.56134533
44MP0001819_abnormal_immune_cell1.55821671
45MP0010155_abnormal_intestine_physiology1.53309057
46MP0001800_abnormal_humoral_immune1.50930859
47MP0005025_abnormal_response_to1.47719006
48MP0003566_abnormal_cell_adhesion1.47318607
49MP0008007_abnormal_cellular_replicative1.46389084
50MP0003195_calcinosis1.44561527
51MP0004272_abnormal_basement_membrane1.43462509
52MP0000490_abnormal_crypts_of1.43013694
53MP0003191_abnormal_cellular_cholesterol1.42272838
54MP0002009_preneoplasia1.42017011
55MP0004381_abnormal_hair_follicle1.40466266
56MP0002723_abnormal_immune_serum1.38752145
57MP0009333_abnormal_splenocyte_physiolog1.38172869
58MP0003943_abnormal_hepatobiliary_system1.37140145
59MP0003763_abnormal_thymus_physiology1.35471677
60MP0005174_abnormal_tail_pigmentation1.35101758
61MP0001790_abnormal_immune_system1.34184665
62MP0005387_immune_system_phenotype1.34184665
63MP0010307_abnormal_tumor_latency1.30869437
64MP0003705_abnormal_hypodermis_morpholog1.30839934
65MP0001533_abnormal_skeleton_physiology1.29949297
66MP0002405_respiratory_system_inflammati1.28073761
67* MP0000716_abnormal_immune_system1.27540834
68MP0000767_abnormal_smooth_muscle1.26935892
69* MP0001915_intracranial_hemorrhage1.26842823
70* MP0000689_abnormal_spleen_morphology1.25908440
71* MP0002722_abnormal_immune_system1.24708970
72* MP0002429_abnormal_blood_cell1.22087869
73MP0004264_abnormal_extraembryonic_tissu1.22024967
74MP0005171_absent_coat_pigmentation1.21256482
75MP0005623_abnormal_meninges_morphology1.19896555
76MP0003448_altered_tumor_morphology1.19735461
77MP0003828_pulmonary_edema1.17534480
78MP0005275_abnormal_skin_tensile1.16004023
79MP0001873_stomach_inflammation1.15857250
80MP0006082_CNS_inflammation1.13376156
81MP0004947_skin_inflammation1.11644030
82MP0000733_abnormal_muscle_development1.11147665
83MP0009697_abnormal_copulation1.10131195
84MP0001958_emphysema1.09926791
85MP0004084_abnormal_cardiac_muscle1.09785384
86MP0005197_abnormal_uvea_morphology1.09363749
87MP0005167_abnormal_blood-brain_barrier1.09035940
88MP0005058_abnormal_lysosome_morphology1.05072305
89MP0000858_altered_metastatic_potential1.04485066
90MP0000569_abnormal_digit_pigmentation1.04471872
91MP0001845_abnormal_inflammatory_respons1.02794490
92MP0005023_abnormal_wound_healing1.01826896
93MP0004883_abnormal_blood_vessel1.01540579
94* MP0000703_abnormal_thymus_morphology1.00140769
95MP0003567_abnormal_fetal_cardiomyocyte0.99619840
96MP0005409_darkened_coat_color0.98621386
97MP0004484_altered_response_of0.97621133
98MP0009384_cardiac_valve_regurgitation0.97579537
99MP0005076_abnormal_cell_differentiation0.96152186
100MP0000343_altered_response_to0.95645904
101MP0003091_abnormal_cell_migration0.95564954
102MP0001324_abnormal_eye_pigmentation0.93850456
103MP0001853_heart_inflammation0.92679239
104MP0002998_abnormal_bone_remodeling0.90650598
105MP0005164_abnormal_response_to0.90100647
106MP0003656_abnormal_erythrocyte_physiolo0.89920326
107MP0005390_skeleton_phenotype0.89457290
108MP0001186_pigmentation_phenotype0.88963487
109MP0002254_reproductive_system_inflammat0.88647527
110MP0002075_abnormal_coat/hair_pigmentati0.88411306
111MP0004782_abnormal_surfactant_physiolog0.87666910
112MP0001849_ear_inflammation0.86983522
113MP0005503_abnormal_tendon_morphology0.85287865
114MP0010678_abnormal_skin_adnexa0.84985664
115MP0003453_abnormal_keratinocyte_physiol0.84212934
116MP0002128_abnormal_blood_circulation0.82764240
117* MP0002925_abnormal_cardiovascular_devel0.82545983
118MP0010094_abnormal_chromosome_stability0.81693993
119MP0001851_eye_inflammation0.81358213
120MP0002168_other_aberrant_phenotype0.79935620
121* MP0002086_abnormal_extraembryonic_tissu0.79890633
122MP0008260_abnormal_autophagy0.79502830
123MP0002896_abnormal_bone_mineralization0.79488591
124MP0000516_abnormal_urinary_system0.79306340
125MP0005367_renal/urinary_system_phenotyp0.79306340
126MP0002102_abnormal_ear_morphology0.79212546
127MP0003077_abnormal_cell_cycle0.78975533
128MP0000428_abnormal_craniofacial_morphol0.77876501
129MP0002090_abnormal_vision0.76759681
130MP0002060_abnormal_skin_morphology0.76503760
131MP0003221_abnormal_cardiomyocyte_apopto0.75643033
132MP0004134_abnormal_chest_morphology0.75204050
133MP0003866_abnormal_defecation0.74615816
134MP0002088_abnormal_embryonic_growth/wei0.73772230
135MP0003045_fibrosis0.73480432
136MP0002928_abnormal_bile_duct0.73301282
137MP0002933_joint_inflammation0.73276293
138MP0005621_abnormal_cell_physiology0.72605300
139MP0000383_abnormal_hair_follicle0.72504817
140MP0003984_embryonic_growth_retardation0.72417209
141* MP0001614_abnormal_blood_vessel0.72266955
142MP0002019_abnormal_tumor_incidence0.71138472
143MP0000249_abnormal_blood_vessel0.70942220
144MP0001191_abnormal_skin_condition0.69619742
145MP0000427_abnormal_hair_cycle0.67170882
146MP0005248_abnormal_Harderian_gland0.67088937
147MP0000377_abnormal_hair_follicle0.66425910
148MP0002095_abnormal_skin_pigmentation0.65365469

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)3.68306391
2T lymphocytopenia (HP:0005403)3.53641070
3Asymmetry of the thorax (HP:0001555)3.45784303
4Syringomyelia (HP:0003396)3.24502507
5Spinal cord lesions (HP:0100561)3.24502507
6Recurrent abscess formation (HP:0002722)3.22038427
7Eczematoid dermatitis (HP:0000976)3.16743876
8Abnormality of T cell number (HP:0011839)3.13679046
9Thrombocytosis (HP:0001894)3.12772870
10Thyroiditis (HP:0100646)3.06652471
11Subacute progressive viral hepatitis (HP:0006572)3.02024595
12Myocardial infarction (HP:0001658)3.00519194
13Myositis (HP:0100614)2.97485705
14Hematochezia (HP:0002573)2.80426636
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.78261588
16Osteolytic defects of the hand bones (HP:0009699)2.78261588
17Recurrent bacterial skin infections (HP:0005406)2.78009118
18Papillary thyroid carcinoma (HP:0002895)2.75031079
19Aortic aneurysm (HP:0004942)2.70707702
20Arterial thrombosis (HP:0004420)2.70105261
21Cerebral aneurysm (HP:0004944)2.68810644
22Cellulitis (HP:0100658)2.65153675
23Aortic dissection (HP:0002647)2.58677766
24Volvulus (HP:0002580)2.57672267
25Spondylolisthesis (HP:0003302)2.57198670
26Spontaneous hematomas (HP:0007420)2.56077852
27Increased cerebral lipofuscin (HP:0011813)2.55138103
28Petechiae (HP:0000967)2.53839855
29Orchitis (HP:0100796)2.50761337
30Transitional cell carcinoma of the bladder (HP:0006740)2.48226933
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.48040306
32Prolonged bleeding time (HP:0003010)2.44372349
33Vascular tortuosity (HP:0004948)2.40213726
34Arterial tortuosity (HP:0005116)2.39259095
35Protrusio acetabuli (HP:0003179)2.37768237
36Bladder neoplasm (HP:0009725)2.36624682
37Bladder carcinoma (HP:0002862)2.36624682
38Absent frontal sinuses (HP:0002688)2.35689007
39Ocular albinism (HP:0001107)2.34468684
40Abnormal platelet volume (HP:0011876)2.33010383
41Abnormality of the nasal septum (HP:0000419)2.32798062
42Recurrent viral infections (HP:0004429)2.29852933
43Viral hepatitis (HP:0006562)2.28772699
44Neoplasm of the adrenal cortex (HP:0100641)2.28379130
45Thyroid carcinoma (HP:0002890)2.28061784
46Abnormal auditory evoked potentials (HP:0006958)2.27786170
47Autoimmune thrombocytopenia (HP:0001973)2.25983881
48Cardiovascular calcification (HP:0011915)2.25837167
49Cutaneous melanoma (HP:0012056)2.25252988
50Periodontitis (HP:0000704)2.23354580
51Abnormal foot bone ossification (HP:0010675)2.23003545
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22911305
53Short 4th metacarpal (HP:0010044)2.22911305
54Hypoplasia of the thymus (HP:0000778)2.21979281
55Acute myeloid leukemia (HP:0004808)2.21678005
56Inappropriate behavior (HP:0000719)2.20439116
57Elevated erythrocyte sedimentation rate (HP:0003565)2.20419769
58Abnormality of the fingertips (HP:0001211)2.20041098
59Tetraparesis (HP:0002273)2.19988424
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17957908
61Ankyloglossia (HP:0010296)2.17692955
62Aplasia/Hypoplasia of the macula (HP:0008059)2.16395974
63Recurrent fungal infections (HP:0002841)2.15528309
64Retrobulbar optic neuritis (HP:0100654)2.14925683
65Optic neuritis (HP:0100653)2.14925683
66Freckling (HP:0001480)2.14700180
67Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.13860999
68Bilateral sensorineural hearing impairment (HP:0008619)2.12422910
69Peritonitis (HP:0002586)2.12407953
70Abnormality of oral frenula (HP:0000190)2.11696549
71Chest pain (HP:0100749)2.09508453
72Increased mean platelet volume (HP:0011877)2.09483340
73Nonimmune hydrops fetalis (HP:0001790)2.08080135
74Aqueductal stenosis (HP:0002410)2.08010971
75Osteomyelitis (HP:0002754)2.06478541
76Gingival bleeding (HP:0000225)2.06429124
77Iris hypopigmentation (HP:0007730)2.06338295
78Thin bony cortex (HP:0002753)2.06001707
79Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05760631
80Enlarged penis (HP:0000040)2.04854026
81IgM deficiency (HP:0002850)2.04460759
82Hypoplasia of the iris (HP:0007676)2.03327432
83Albinism (HP:0001022)2.03204847
84Vasculitis (HP:0002633)2.03021264
85Vascular calcification (HP:0004934)2.01869966
86Severe combined immunodeficiency (HP:0004430)1.98621151
87Curly hair (HP:0002212)1.96686144
88Conjunctival telangiectasia (HP:0000524)1.96256416
89Leiomyosarcoma (HP:0100243)1.95842871
90Uterine leiomyosarcoma (HP:0002891)1.95842871
91Pustule (HP:0200039)1.94696076
92Thickened calvaria (HP:0002684)1.93471693
93Acanthocytosis (HP:0001927)1.92402388
94Cervical subluxation (HP:0003308)1.92165160
95Soft skin (HP:0000977)1.91865332
96Dilatation of the ascending aorta (HP:0005111)1.91474642
97Germ cell neoplasia (HP:0100728)1.90187181
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.89808825
99Bicuspid aortic valve (HP:0001647)1.88136103
100Mitral stenosis (HP:0001718)1.87748985
101Mitral valve prolapse (HP:0001634)1.85958583
102Overgrowth (HP:0001548)1.85721405
103Combined immunodeficiency (HP:0005387)1.85676346
104Gastrointestinal carcinoma (HP:0002672)1.85560043
105Malignant gastrointestinal tract tumors (HP:0006749)1.85560043
106Mediastinal lymphadenopathy (HP:0100721)1.85123654
107B lymphocytopenia (HP:0010976)1.83297396
108Thick nail (HP:0001805)1.82820269
109Impaired platelet aggregation (HP:0003540)1.82728456
110Abnormal platelet function (HP:0011869)1.82728456
111Macroorchidism (HP:0000053)1.82656465
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81773751
113Interstitial pulmonary disease (HP:0006530)1.81609526
114Meningitis (HP:0001287)1.81597122
115Eosinophilia (HP:0001880)1.81042983
116Abnormality of B cell number (HP:0010975)1.80139887
117Coarse hair (HP:0002208)1.79742306
118Keratoconjunctivitis sicca (HP:0001097)1.79281666
119Esophageal varix (HP:0002040)1.79177284
120Micronodular cirrhosis (HP:0001413)1.78944119
121Relative macrocephaly (HP:0004482)1.77507809
122Epistaxis (HP:0000421)1.76934682
123IgA deficiency (HP:0002720)1.76478604
124Chronic otitis media (HP:0000389)1.76377800
125Pulmonic stenosis (HP:0001642)1.76319033
126Ankle contracture (HP:0006466)1.73260675
127Submucous cleft hard palate (HP:0000176)1.72146920
128Premature rupture of membranes (HP:0001788)1.71825304
129Striae distensae (HP:0001065)1.71624956
130Persistence of primary teeth (HP:0006335)1.70938316
131Follicular hyperkeratosis (HP:0007502)1.70243349
132Abnormality of the prostate (HP:0008775)1.69484582
133Facial diplegia (HP:0001349)1.68976866
134Generalized hypopigmentation of hair (HP:0011358)1.68967950
135Bruising susceptibility (HP:0000978)1.68687261
136Blue irides (HP:0000635)1.68360552
137Mucopolysacchariduria (HP:0008155)1.67489564
138Urinary glycosaminoglycan excretion (HP:0003541)1.67489564
139Cutis marmorata (HP:0000965)1.67486315
140Flat acetabular roof (HP:0003180)1.66245777
141Shallow orbits (HP:0000586)1.65781866
142Thoracolumbar scoliosis (HP:0002944)1.65748119
143Abnormality of the frontal sinuses (HP:0002687)1.65336361
144Deviation of the thumb (HP:0009603)1.65298023
145Long eyelashes (HP:0000527)1.64729482
146Generalized hypopigmentation (HP:0007513)1.64690852
147Atrophic scars (HP:0001075)1.64561334
148Abnormality of liposaccharide metabolism (HP:0010968)1.64467885
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.64467885
150Abnormality of glycolipid metabolism (HP:0010969)1.64467885
151Deep philtrum (HP:0002002)1.64247282
152Increased density of long bones (HP:0006392)1.64171417
153Hypoproteinemia (HP:0003075)1.64104953
154Large earlobe (HP:0009748)1.63794647
155Recurrent skin infections (HP:0001581)1.63416689
156Mucosal telangiectasiae (HP:0100579)1.62683462
157Vertebral compression fractures (HP:0002953)1.62495295
158Keratoconjunctivitis (HP:0001096)1.62228200
159Vacuolated lymphocytes (HP:0001922)1.62121022
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.61170424
161Abnormality of the lumbar spine (HP:0100712)1.61160747
162Obstructive lung disease (HP:0006536)1.60877414
163Chronic obstructive pulmonary disease (HP:0006510)1.60877414
164Abnormality of macrophages (HP:0004311)1.60385815
165Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.60008596
166Leukocytosis (HP:0001974)1.59455580
167Abnormality of the anterior horn cell (HP:0006802)1.58440185
168Degeneration of anterior horn cells (HP:0002398)1.58440185
169Broad palm (HP:0001169)1.57174056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS12.97473933
2TGFBR22.87870668
3PKN22.77894713
4MAP4K12.51371731
5TRIM282.45149269
6EIF2AK32.39923999
7TRIB32.39067763
8MAP3K142.37450544
9TRPM72.15138962
10JAK32.13457650
11SIK32.09394871
12FER2.06644342
13STK102.03698645
14PLK22.00437536
15BMPR1B2.00388232
16RIPK11.99544485
17TIE11.98890207
18AKT31.98790404
19NEK91.92438624
20MKNK11.90123364
21ERBB31.82468754
22FGFR31.81074305
23TGFBR11.78925094
24CLK11.78857316
25FRK1.76501096
26MET1.75522741
27PTK61.71812956
28TXK1.66513715
29EEF2K1.65247204
30CDK61.63581307
31LRRK21.61087785
32KIT1.61004120
33BCR1.60279211
34BTK1.59646655
35TBK11.59622286
36BMPR21.56686604
37ZAP701.50890921
38CDC71.46926151
39ERN11.46299220
40KDR1.45087255
41IRAK41.43040378
42TYK21.40083013
43MAP3K101.39937647
44PAK41.39895161
45PIK3CG1.38454279
46ERBB41.37961003
47TEC1.37856707
48SCYL21.33150780
49CHUK1.28869512
50FGR1.28780491
51FGFR21.27515257
52IKBKE1.27304400
53RPS6KA41.26848794
54MAP2K31.26840532
55MST1R1.25431699
56MAP3K21.23053595
57STK38L1.22922685
58PIM11.22113772
59STK31.16189408
60CAMKK21.11149929
61PASK1.09570577
62KSR11.07592847
63CSF1R1.06952118
64MATK1.05978167
65BRD41.03989882
66CDK81.03405510
67ITK1.02007784
68TAF11.00640952
69JAK11.00474039
70MAP3K130.99520227
71SYK0.99407650
72STK40.98096558
73IKBKB0.96487167
74FES0.95902923
75EPHB10.95085473
76EIF2AK10.93814196
77BRSK20.93155709
78IRAK10.92566936
79WEE10.90639684
80MKNK20.87397215
81FGFR10.87137723
82ZAK0.86139496
83PDGFRA0.85053236
84CDK40.84866409
85STK390.83768202
86RPS6KA60.82765713
87PTK20.82619636
88PIM20.82252940
89PLK30.81603861
90HCK0.81482708
91NUAK10.80526217
92STK240.77154267
93TTN0.75348216
94LYN0.72476612
95LCK0.68943776
96PLK40.66755023
97WNK10.66340812
98JAK20.65495645
99CSK0.65036875
100BLK0.64590674
101PBK0.64341850
102NEK20.63239745
103MAP3K80.60016891
104MAPKAPK20.58824259
105PDGFRB0.58611895
106PTK2B0.56556469
107CAMK1G0.55667095
108MAP3K30.55119689
109DYRK1B0.54675826
110IRAK20.54592458
111RPS6KB10.53807114
112SGK30.53104920
113PRKCE0.52916096
114FLT30.52120766
115EIF2AK20.51022834
116RPS6KC10.50778746
117RPS6KL10.50778746
118MST40.50287606
119MOS0.50128874
120NLK0.49304624
121PAK20.48861711
122GRK70.48667160
123CAMK1D0.47665156
124ERBB20.47645746
125SGK20.47263668
126INSRR0.46958964
127MARK30.46449120
128EPHA30.45582339
129ROCK20.44958114
130CDK120.44867609
131CDK90.44722639
132ILK0.44223567
133ACVR1B0.43704093
134AURKB0.42415509
135RPS6KB20.41892725
136PRKCH0.41774694
137TNIK0.41464441
138MELK0.40913309
139IGF1R0.40883639
140GRK60.40825147
141PAK30.40720344
142ATR0.40118453
143YES10.39802016
144CAMKK10.39797776
145MAPK70.39774141
146HIPK20.38660380
147STK380.38237710
148PRKG20.37630986
149ABL10.37484024
150FGFR40.37359843
151EGFR0.37045978

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.26161340
2Chronic myeloid leukemia_Homo sapiens_hsa052201.78733212
3Toxoplasmosis_Homo sapiens_hsa051451.77135833
4Small cell lung cancer_Homo sapiens_hsa052221.75121274
5Osteoclast differentiation_Homo sapiens_hsa043801.75077502
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74815180
7Measles_Homo sapiens_hsa051621.73900067
8Non-homologous end-joining_Homo sapiens_hsa034501.72872231
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.72003010
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.68133577
11Antigen processing and presentation_Homo sapiens_hsa046121.67282722
12B cell receptor signaling pathway_Homo sapiens_hsa046621.64985053
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.64132925
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59723826
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54979497
16Legionellosis_Homo sapiens_hsa051341.53078315
17Hematopoietic cell lineage_Homo sapiens_hsa046401.52593982
18Shigellosis_Homo sapiens_hsa051311.50481580
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49688001
20Hepatitis B_Homo sapiens_hsa051611.47077656
21Pancreatic cancer_Homo sapiens_hsa052121.46660213
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45680826
23Platelet activation_Homo sapiens_hsa046111.43251670
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.40784968
25Viral myocarditis_Homo sapiens_hsa054161.39728305
26Malaria_Homo sapiens_hsa051441.37599744
27Herpes simplex infection_Homo sapiens_hsa051681.35521930
28TNF signaling pathway_Homo sapiens_hsa046681.34439443
29Dorso-ventral axis formation_Homo sapiens_hsa043201.32424583
30Influenza A_Homo sapiens_hsa051641.31956163
31Focal adhesion_Homo sapiens_hsa045101.30147514
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30097255
33Pertussis_Homo sapiens_hsa051331.29160828
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27736226
35Cell cycle_Homo sapiens_hsa041101.27489403
36ECM-receptor interaction_Homo sapiens_hsa045121.26280725
37Apoptosis_Homo sapiens_hsa042101.26067530
38DNA replication_Homo sapiens_hsa030301.24889230
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23867453
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23829297
41MicroRNAs in cancer_Homo sapiens_hsa052061.21888837
42Adherens junction_Homo sapiens_hsa045201.20954158
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20131485
44Primary immunodeficiency_Homo sapiens_hsa053401.20029068
45Salmonella infection_Homo sapiens_hsa051321.19873035
46Renal cell carcinoma_Homo sapiens_hsa052111.19804281
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.19743352
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19486922
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19474086
50Tuberculosis_Homo sapiens_hsa051521.16310189
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14255949
52Proteoglycans in cancer_Homo sapiens_hsa052051.08762693
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06431033
54Base excision repair_Homo sapiens_hsa034101.05761692
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.05584153
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04739719
57HTLV-I infection_Homo sapiens_hsa051661.04496047
58Chemokine signaling pathway_Homo sapiens_hsa040621.03352079
59Amoebiasis_Homo sapiens_hsa051460.99934993
60Non-small cell lung cancer_Homo sapiens_hsa052230.99604776
61Colorectal cancer_Homo sapiens_hsa052100.97240960
62p53 signaling pathway_Homo sapiens_hsa041150.96473135
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96338131
64Acute myeloid leukemia_Homo sapiens_hsa052210.95543003
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94560092
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.93660920
67Complement and coagulation cascades_Homo sapiens_hsa046100.92978035
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92828018
69Inositol phosphate metabolism_Homo sapiens_hsa005620.92418375
70Viral carcinogenesis_Homo sapiens_hsa052030.91342144
71Thyroid cancer_Homo sapiens_hsa052160.90036966
72Prostate cancer_Homo sapiens_hsa052150.89937601
73T cell receptor signaling pathway_Homo sapiens_hsa046600.89910907
74Sphingolipid metabolism_Homo sapiens_hsa006000.89816119
75Lysosome_Homo sapiens_hsa041420.89126023
76Prolactin signaling pathway_Homo sapiens_hsa049170.87858133
77Endometrial cancer_Homo sapiens_hsa052130.87798462
78N-Glycan biosynthesis_Homo sapiens_hsa005100.87538068
79mTOR signaling pathway_Homo sapiens_hsa041500.87430508
80Allograft rejection_Homo sapiens_hsa053300.86258950
81Sulfur metabolism_Homo sapiens_hsa009200.85822170
82Hepatitis C_Homo sapiens_hsa051600.85200487
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83678783
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82189022
85Notch signaling pathway_Homo sapiens_hsa043300.80684735
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80593866
87TGF-beta signaling pathway_Homo sapiens_hsa043500.78408994
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78154819
89Hippo signaling pathway_Homo sapiens_hsa043900.77691625
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77415206
91Staphylococcus aureus infection_Homo sapiens_hsa051500.77005499
92Selenocompound metabolism_Homo sapiens_hsa004500.75666526
93Asthma_Homo sapiens_hsa053100.75107154
94Other glycan degradation_Homo sapiens_hsa005110.74892197
95Pathways in cancer_Homo sapiens_hsa052000.74625555
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73544164
97HIF-1 signaling pathway_Homo sapiens_hsa040660.73086752
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73043360
99Graft-versus-host disease_Homo sapiens_hsa053320.71971878
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70597588
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69705040
102FoxO signaling pathway_Homo sapiens_hsa040680.69157961
103Tight junction_Homo sapiens_hsa045300.65845573
104Epstein-Barr virus infection_Homo sapiens_hsa051690.65449356
105Protein export_Homo sapiens_hsa030600.64556523
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63665676
107Phagosome_Homo sapiens_hsa041450.63573913
108Glioma_Homo sapiens_hsa052140.62642156
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.62412171
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62132745
111Steroid biosynthesis_Homo sapiens_hsa001000.61594501
112Rap1 signaling pathway_Homo sapiens_hsa040150.61549254
113Insulin resistance_Homo sapiens_hsa049310.61297654
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.60335382
115RNA degradation_Homo sapiens_hsa030180.59877170
116Renin-angiotensin system_Homo sapiens_hsa046140.57345934
117VEGF signaling pathway_Homo sapiens_hsa043700.56481686
118Bladder cancer_Homo sapiens_hsa052190.55546312
119Ras signaling pathway_Homo sapiens_hsa040140.54530966
120Wnt signaling pathway_Homo sapiens_hsa043100.54191593
121Mismatch repair_Homo sapiens_hsa034300.54171497
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.53797815
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53658736
124Melanoma_Homo sapiens_hsa052180.53288572
125Endocytosis_Homo sapiens_hsa041440.52120799
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50657975
127Rheumatoid arthritis_Homo sapiens_hsa053230.48459482
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47016217
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46973126

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