ADA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.71797999
2adhesion of symbiont to host cell (GO:0044650)6.65462196
3virion attachment to host cell (GO:0019062)6.65462196
4vitamin A metabolic process (GO:0006776)6.63150611
5positive regulation of triglyceride lipase activity (GO:0061365)6.54998675
6positive regulation of lipoprotein lipase activity (GO:0051006)6.54998675
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.02781493
8adhesion of symbiont to host (GO:0044406)5.75496509
9phospholipid efflux (GO:0033700)5.19763874
10positive regulation of gamma-delta T cell activation (GO:0046645)5.19359007
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07954032
12digestive system process (GO:0022600)4.81765758
13regulation of triglyceride catabolic process (GO:0010896)4.80132347
14regulation of T-helper 1 cell differentiation (GO:0045625)4.75576571
15cytidine deamination (GO:0009972)4.74894113
16cytidine metabolic process (GO:0046087)4.74894113
17cytidine catabolic process (GO:0006216)4.74894113
18immunoglobulin mediated immune response (GO:0016064)4.63722468
19regulation of cholesterol esterification (GO:0010872)4.60670961
20plasma lipoprotein particle assembly (GO:0034377)4.57005795
21protein-lipid complex assembly (GO:0065005)4.48210539
22modified amino acid transport (GO:0072337)4.48177445
23actin filament depolymerization (GO:0030042)4.46733665
24regulation of vitamin D biosynthetic process (GO:0060556)4.32872174
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.14433944
26flavonoid metabolic process (GO:0009812)4.11043828
27peptide catabolic process (GO:0043171)4.10825661
28cholesterol efflux (GO:0033344)4.04176594
29negative regulation of interleukin-12 production (GO:0032695)4.03582309
30* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91264786
31innate immune response in mucosa (GO:0002227)3.88367019
32lipoprotein metabolic process (GO:0042157)3.88361946
33hormone catabolic process (GO:0042447)3.86806382
34NIK/NF-kappaB signaling (GO:0038061)3.85077875
35B cell mediated immunity (GO:0019724)3.85013787
36drug catabolic process (GO:0042737)3.81846318
37protein kinase C signaling (GO:0070528)3.81789664
38type I interferon signaling pathway (GO:0060337)3.78683032
39cellular response to type I interferon (GO:0071357)3.78683032
40response to protozoan (GO:0001562)3.77365678
41response to peptidoglycan (GO:0032494)3.75602960
42response to type I interferon (GO:0034340)3.74484561
43regulation of interferon-alpha production (GO:0032647)3.69864448
44transcytosis (GO:0045056)3.69776386
45defense response to protozoan (GO:0042832)3.68949103
46drinking behavior (GO:0042756)3.67659739
47positive regulation of B cell differentiation (GO:0045579)3.64769928
48regulation of chronic inflammatory response (GO:0002676)3.62752383
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.62226988
50response to hepatocyte growth factor (GO:0035728)3.61722581
51cellular response to hepatocyte growth factor stimulus (GO:0035729)3.61722581
52UDP-N-acetylglucosamine metabolic process (GO:0006047)3.58651197
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.57675175
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.57675175
55T cell migration (GO:0072678)3.50282234
56regulation of gamma-delta T cell activation (GO:0046643)3.48861076
57phospholipid scrambling (GO:0017121)3.48556700
58glucose 6-phosphate metabolic process (GO:0051156)3.47209206
59regulation of vitamin metabolic process (GO:0030656)3.44787469
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43354135
61reverse cholesterol transport (GO:0043691)3.42969001
62diacylglycerol metabolic process (GO:0046339)3.42689962
63digestion (GO:0007586)3.39268450
64interferon-gamma-mediated signaling pathway (GO:0060333)3.37029974
65very-low-density lipoprotein particle assembly (GO:0034379)3.36326804
66cholesterol homeostasis (GO:0042632)3.32310721
67positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.32246925
68cholesterol transport (GO:0030301)3.31189735
69sterol transport (GO:0015918)3.31189735
70positive regulation of antigen processing and presentation (GO:0002579)3.30131953
71negative regulation of cholesterol transport (GO:0032375)3.29400086
72negative regulation of sterol transport (GO:0032372)3.29400086
73sulfation (GO:0051923)3.27936976
74regulation of cytokine secretion involved in immune response (GO:0002739)3.27146571
75response to hydroperoxide (GO:0033194)3.26657808
76activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.26288288
77negative regulation of nitric oxide biosynthetic process (GO:0045019)3.26175183
78sterol homeostasis (GO:0055092)3.25844963
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25535526
80peptide hormone processing (GO:0016486)3.23992456
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23865676
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23865676
83regulation of chemokine biosynthetic process (GO:0045073)3.23416190
84positive regulation of chemokine biosynthetic process (GO:0045080)3.22372097
85lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20821026
86Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20164525
87positive thymic T cell selection (GO:0045059)3.17829803
88positive regulation of interferon-alpha production (GO:0032727)3.16944134
89positive regulation of fatty acid biosynthetic process (GO:0045723)3.15916665
90thyroid hormone metabolic process (GO:0042403)3.15214866
91positive regulation of defense response to virus by host (GO:0002230)3.14884812
92negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.13969134
93negative regulation of myeloid cell apoptotic process (GO:0033033)3.13945820
94myeloid dendritic cell activation (GO:0001773)3.13937009
95regulation of antigen processing and presentation (GO:0002577)3.13924967
96mucosal immune response (GO:0002385)3.13135238
97bundle of His cell to Purkinje myocyte communication (GO:0086069)3.10508351
98antigen processing and presentation of endogenous antigen (GO:0019883)3.10028751
99negative regulation of viral genome replication (GO:0045071)3.09569886
100regulation of immunoglobulin secretion (GO:0051023)3.09282678
101negative T cell selection (GO:0043383)3.08565989
102response to interferon-beta (GO:0035456)3.07342754
103positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06765482
104hydrogen peroxide catabolic process (GO:0042744)3.04487953
105viral entry into host cell (GO:0046718)3.04080889
106cellular response to interferon-beta (GO:0035458)3.03653421
107regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00244125
108regulation of gamma-delta T cell differentiation (GO:0045586)2.99105766
109actin nucleation (GO:0045010)2.97759285
110positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.97756964
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.97231233
112hepatocyte apoptotic process (GO:0097284)2.96600271
113negative thymic T cell selection (GO:0045060)2.96596018
114sulfate transmembrane transport (GO:1902358)2.96379554
115positive regulation of triglyceride metabolic process (GO:0090208)2.95772007
116regulation of lipoprotein metabolic process (GO:0050746)2.94847056
117regulation of interleukin-12 production (GO:0032655)2.94604413
118negative regulation of cytokine production involved in immune response (GO:0002719)2.93995817
119positive regulation of type 2 immune response (GO:0002830)2.93763956
120neutrophil activation involved in immune response (GO:0002283)2.93710571
121regulation of alpha-beta T cell proliferation (GO:0046640)2.93265992
122regulation of interleukin-2 biosynthetic process (GO:0045076)2.92776922
123myeloid dendritic cell differentiation (GO:0043011)2.92639982
124lipoprotein transport (GO:0042953)2.92624574
125organ or tissue specific immune response (GO:0002251)2.91596145
126negative regulation of growth of symbiont in host (GO:0044130)2.90591462
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.90591462
128modulation of growth of symbiont involved in interaction with host (GO:0044144)2.90591462
129regulation of growth of symbiont in host (GO:0044126)2.90591462
130oligosaccharide catabolic process (GO:0009313)2.89507018
131positive regulation of T-helper cell differentiation (GO:0045624)2.86967431
132drug transport (GO:0015893)2.86082592
133regulation of digestive system process (GO:0044058)2.86010291
134positive T cell selection (GO:0043368)2.85195765
135response to muramyl dipeptide (GO:0032495)2.84893148
136negative regulation of digestive system process (GO:0060457)2.83792406
137positive regulation of interleukin-2 production (GO:0032743)2.83029438
138positive regulation of interferon-beta production (GO:0032728)2.82460374
139protein-lipid complex subunit organization (GO:0071825)2.80266716
140high-density lipoprotein particle remodeling (GO:0034375)2.80266396
141regulation of inflammatory response to antigenic stimulus (GO:0002861)2.78915741
142B cell receptor signaling pathway (GO:0050853)2.78314183
143positive regulation of natural killer cell differentiation (GO:0032825)2.78199144
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77092062
145regulation of T-helper cell differentiation (GO:0045622)2.76420415
146cellular response to interferon-gamma (GO:0071346)2.76095519
147T-helper 1 type immune response (GO:0042088)2.75797234
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.75754857
149negative regulation of T cell receptor signaling pathway (GO:0050860)2.74979961
150positive regulation of interleukin-10 production (GO:0032733)2.74205483
151NADH metabolic process (GO:0006734)2.73926699
152keratinization (GO:0031424)2.73758783
153plasma lipoprotein particle organization (GO:0071827)2.73536938
154regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.73375966
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72072488
156regulation of podosome assembly (GO:0071801)2.70914480
157* regulation of B cell apoptotic process (GO:0002902)2.69849549
158maintenance of gastrointestinal epithelium (GO:0030277)2.69526873
159regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69239662
160leukocyte aggregation (GO:0070486)2.68963291
161positive regulation of isotype switching (GO:0045830)2.68678095
162positive regulation of interleukin-12 production (GO:0032735)2.67470521
163thrombin receptor signaling pathway (GO:0070493)2.66846463
164negative regulation of type I interferon production (GO:0032480)2.66829213
165regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65645488
166ribosomal small subunit assembly (GO:0000028)2.65090857
167dendritic cell differentiation (GO:0097028)2.64067820
168positive regulation of heat generation (GO:0031652)2.63094445
169protein-lipid complex remodeling (GO:0034368)2.62894636
170macromolecular complex remodeling (GO:0034367)2.62894636
171plasma lipoprotein particle remodeling (GO:0034369)2.62894636
172regulation of actin nucleation (GO:0051125)2.62713374
173regulation of B cell differentiation (GO:0045577)2.61020822
174regulation of B cell receptor signaling pathway (GO:0050855)2.59391261
175sulfur compound transport (GO:0072348)2.59060102
176T cell selection (GO:0045058)2.59052176
177regulation of cholesterol transport (GO:0032374)2.58790171
178regulation of sterol transport (GO:0032371)2.58790171
179regulation of RIG-I signaling pathway (GO:0039535)2.57943952
180* positive regulation of B cell activation (GO:0050871)2.57735548
181folic acid transport (GO:0015884)2.57647284
182CD4-positive, alpha-beta T cell activation (GO:0035710)2.57277733
183cellular response to oxygen radical (GO:0071450)2.56846368
184removal of superoxide radicals (GO:0019430)2.56846368
185cellular response to superoxide (GO:0071451)2.56846368
186positive regulation of granulocyte differentiation (GO:0030854)2.56388659
187sphingomyelin metabolic process (GO:0006684)2.56312022
188positive regulation of NF-kappaB import into nucleus (GO:0042346)2.56234713
189cellular response to exogenous dsRNA (GO:0071360)2.56149021
190macrophage activation involved in immune response (GO:0002281)2.56081781
191positive regulation by symbiont of host defense response (GO:0052509)2.55429385
192modulation by symbiont of host defense response (GO:0052031)2.55429385
193modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55429385
194positive regulation by organism of defense response of other organism involved in symbiotic interact2.55429385
195modulation by symbiont of host immune response (GO:0052553)2.55429385
196sulfate transport (GO:0008272)2.54672103
197intestinal absorption (GO:0050892)11.3851043
198intestinal cholesterol absorption (GO:0030299)10.6038493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32393126
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.81814082
3* TP63_17297297_ChIP-ChIP_HaCaT_Human4.58826863
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.17429515
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.06736698
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64024853
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.48195365
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43042335
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38497095
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04799133
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95339858
12VDR_21846776_ChIP-Seq_THP-1_Human1.82498368
13GATA4_25053715_ChIP-Seq_YYC3_Human1.81960665
14SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79914829
15MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79855187
16RUNX_20019798_ChIP-Seq_JUKART_Human1.79162670
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77192032
18AR_21909140_ChIP-Seq_LNCAP_Human1.76953922
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.75406293
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74542770
21MYC_22102868_ChIP-Seq_BL_Human1.73324042
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73009736
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72463449
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65884097
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64397997
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64269757
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63868023
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61319972
29GATA6_25053715_ChIP-Seq_YYC3_Human1.60586151
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60480747
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.59967529
32GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59603809
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58041484
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56341669
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.55450434
36SCL_19346495_ChIP-Seq_HPC-7_Human1.53372768
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51912685
38MAF_26560356_Chip-Seq_TH2_Human1.51894930
39GATA3_27048872_Chip-Seq_THYMUS_Human1.51598142
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50562970
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50195631
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50071527
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46498341
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.44963991
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43584905
46GATA1_22025678_ChIP-Seq_K562_Human1.42535286
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.41252241
48SPI1_23547873_ChIP-Seq_NB4_Human1.40823627
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39603369
50* SOX2_20726797_ChIP-Seq_SW620_Human1.39291491
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39271064
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37786961
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.37130925
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36067459
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35363751
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34954129
57MAF_26560356_Chip-Seq_TH1_Human1.34837117
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33713282
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31783883
60* UTX_26944678_Chip-Seq_JUKART_Human1.30660555
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29409989
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28896653
63MYB_26560356_Chip-Seq_TH2_Human1.28676481
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25405735
65CIITA_25753668_ChIP-Seq_RAJI_Human1.24819368
66MYB_26560356_Chip-Seq_TH1_Human1.23642566
67* VDR_24763502_ChIP-Seq_THP-1_Human1.23199393
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21869119
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21570820
70BCL6_27268052_Chip-Seq_Bcells_Human1.21506115
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20639454
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20609968
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20269151
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20135783
75ATF3_27146783_Chip-Seq_COLON_Human1.20071213
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19846957
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19408598
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19134448
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18810859
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17728204
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17715575
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17407567
83VDR_23849224_ChIP-Seq_CD4+_Human1.17367177
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.16887176
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16551751
86GATA3_26560356_Chip-Seq_TH2_Human1.14874338
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14273540
88FOXP3_21729870_ChIP-Seq_TREG_Human1.13660371
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13391005
90RACK7_27058665_Chip-Seq_MCF-7_Human1.11991414
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.11186405
92* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10693671
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10359334
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09504961
95* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08806095
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08000150
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07957878
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07650239
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07393273
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07290741
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06979559
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06970890
103BCOR_27268052_Chip-Seq_Bcells_Human1.06542220
104VDR_24787735_ChIP-Seq_THP-1_Human1.06283042
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05620021
106KDM2B_26808549_Chip-Seq_DND41_Human1.05595130
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05553611
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05356686
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04794146
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.04521636
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03551994
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02621598
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01449635
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.01236876
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.01228226
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00347818
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99762358
118TCF7_22412390_ChIP-Seq_EML_Mouse0.99390381
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.99307751
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99220336
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97325627
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97304212
123* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97215023
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96787923
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96652529
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96544772
127CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96283611
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95947105
129GATA2_19941826_ChIP-Seq_K562_Human0.95621486
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95469058
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95003077
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94180858
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94159698
134MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93696156
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93308635
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93000144
137SPI1_23127762_ChIP-Seq_K562_Human0.92007302
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.91927715
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91696226
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.91635592
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91484299
142* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89034463
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88854197
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86839667
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86839667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.27314110
2MP0001666_abnormal_nutrient_absorption5.25795526
3MP0003303_peritoneal_inflammation4.40017861
4MP0006054_spinal_hemorrhage4.01888285
5MP0009840_abnormal_foam_cell3.74201400
6MP0003183_abnormal_peptide_metabolism3.35853899
7MP0004264_abnormal_extraembryonic_tissu3.05751588
8MP0010234_abnormal_vibrissa_follicle3.01390938
9MP0001790_abnormal_immune_system2.92404438
10MP0005387_immune_system_phenotype2.92404438
11MP0009278_abnormal_bone_marrow2.74695681
12MP0006082_CNS_inflammation2.66460439
13MP0003866_abnormal_defecation2.45149089
14MP0004147_increased_porphyrin_level2.37674542
15MP0005058_abnormal_lysosome_morphology2.36468622
16MP0010329_abnormal_lipoprotein_level2.28083441
17MP0009764_decreased_sensitivity_to2.22780121
18MP0000490_abnormal_crypts_of2.14805673
19MP0010155_abnormal_intestine_physiology2.11855595
20MP0002139_abnormal_hepatobiliary_system1.93391688
21MP0005085_abnormal_gallbladder_physiolo1.86615423
22MP0000462_abnormal_digestive_system1.85127218
23MP0001853_heart_inflammation1.84815971
24MP0003693_abnormal_embryo_hatching1.78478297
25MP0008875_abnormal_xenobiotic_pharmacok1.72967299
26MP0004510_myositis1.72581465
27MP0010352_gastrointestinal_tract_polyps1.71650498
28MP0001663_abnormal_digestive_system1.70889383
29MP0003075_altered_response_to1.68308148
30MP0001533_abnormal_skeleton_physiology1.66677399
31MP0001873_stomach_inflammation1.65489998
32MP0002396_abnormal_hematopoietic_system1.54253966
33MP0005451_abnormal_body_composition1.53590162
34MP0003705_abnormal_hypodermis_morpholog1.52938544
35MP0003300_gastrointestinal_ulcer1.52050904
36MP0000477_abnormal_intestine_morphology1.47004841
37MP0005381_digestive/alimentary_phenotyp1.45667532
38MP0002254_reproductive_system_inflammat1.38830144
39MP0005084_abnormal_gallbladder_morpholo1.37784250
40MP0004947_skin_inflammation1.36897446
41MP0003806_abnormal_nucleotide_metabolis1.34883045
42MP0005464_abnormal_platelet_physiology1.34740408
43MP0004808_abnormal_hematopoietic_stem1.34511895
44* MP0000703_abnormal_thymus_morphology1.34036924
45MP0003172_abnormal_lysosome_physiology1.33886666
46MP0001835_abnormal_antigen_presentation1.33236895
47MP0003191_abnormal_cellular_cholesterol1.31658774
48MP0002796_impaired_skin_barrier1.28430723
49MP0005075_abnormal_melanosome_morpholog1.25617020
50MP0009379_abnormal_foot_pigmentation1.25566298
51MP0009333_abnormal_splenocyte_physiolog1.24133525
52MP0008004_abnormal_stomach_pH1.23292671
53MP0003448_altered_tumor_morphology1.23256783
54MP0009785_altered_susceptibility_to1.17540046
55MP0005310_abnormal_salivary_gland1.17523570
56MP0005501_abnormal_skin_physiology1.16464749
57MP0000343_altered_response_to1.16155562
58MP0004019_abnormal_vitamin_homeostasis1.14447799
59MP0002148_abnormal_hypersensitivity_rea1.13244330
60* MP0003252_abnormal_bile_duct1.11313404
61MP0001800_abnormal_humoral_immune1.10945316
62MP0005166_decreased_susceptibility_to1.07647797
63MP0004957_abnormal_blastocyst_morpholog1.06775087
64MP0009763_increased_sensitivity_to1.06185902
65MP0002452_abnormal_antigen_presenting1.03427420
66MP0003567_abnormal_fetal_cardiomyocyte1.02612865
67MP0000537_abnormal_urethra_morphology1.02223847
68MP0004043_abnormal_pH_regulation1.01495911
69MP0001849_ear_inflammation1.00941389
70MP0003763_abnormal_thymus_physiology0.99102558
71MP0000465_gastrointestinal_hemorrhage0.97563976
72MP0008007_abnormal_cellular_replicative0.97332910
73MP0002398_abnormal_bone_marrow0.96897006
74MP0002166_altered_tumor_susceptibility0.96892329
75MP0002420_abnormal_adaptive_immunity0.96642272
76MP0001819_abnormal_immune_cell0.96183816
77MP0001879_abnormal_lymphatic_vessel0.96097536
78MP0005448_abnormal_energy_balance0.95569883
79MP0003724_increased_susceptibility_to0.95565078
80MP0002019_abnormal_tumor_incidence0.95534216
81MP0005025_abnormal_response_to0.94611881
82MP0000467_abnormal_esophagus_morphology0.92571758
83MP0002332_abnormal_exercise_endurance0.90507686
84MP0005023_abnormal_wound_healing0.90332784
85MP0002933_joint_inflammation0.90298473
86MP0003718_maternal_effect0.89706310
87* MP0005266_abnormal_metabolism0.88906032
88MP0002138_abnormal_hepatobiliary_system0.88441151
89MP0000604_amyloidosis0.88273990
90MP0002429_abnormal_blood_cell0.87634950
91MP0002723_abnormal_immune_serum0.87471888
92MP0000249_abnormal_blood_vessel0.85496202
93MP0003436_decreased_susceptibility_to0.85349524
94MP0001664_abnormal_digestion0.85276809
95MP0001764_abnormal_homeostasis0.85261904
96MP0000716_abnormal_immune_system0.84975529
97MP0003646_muscle_fatigue0.84783413
98MP0009643_abnormal_urine_homeostasis0.84520595
99MP0002089_abnormal_postnatal_growth/wei0.84419284
100* MP0000609_abnormal_liver_physiology0.84228387
101MP0002998_abnormal_bone_remodeling0.84173036
102MP0001191_abnormal_skin_condition0.84137054
103MP0000689_abnormal_spleen_morphology0.84011856
104MP0003878_abnormal_ear_physiology0.83492080
105MP0005377_hearing/vestibular/ear_phenot0.83492080
106MP0010307_abnormal_tumor_latency0.83303725
107MP0001845_abnormal_inflammatory_respons0.83019005
108MP0009765_abnormal_xenobiotic_induced0.81134290
109MP0000858_altered_metastatic_potential0.79085675
110MP0003566_abnormal_cell_adhesion0.77914705
111MP0010094_abnormal_chromosome_stability0.77401172
112* MP0002722_abnormal_immune_system0.76673745
113MP0005174_abnormal_tail_pigmentation0.75496573
114MP0005165_increased_susceptibility_to0.75058008
115MP0006036_abnormal_mitochondrial_physio0.75000278
116MP0005671_abnormal_response_to0.74617890
117MP0005000_abnormal_immune_tolerance0.73404268
118MP0003077_abnormal_cell_cycle0.72964232
119MP0000538_abnormal_urinary_bladder0.71544603
120MP0002419_abnormal_innate_immunity0.70035485
121MP0002095_abnormal_skin_pigmentation0.69607735
122MP0002136_abnormal_kidney_physiology0.69455500
123MP0001730_embryonic_growth_arrest0.69065966
124MP0003186_abnormal_redox_activity0.68627159
125MP0001216_abnormal_epidermal_layer0.68618677
126MP0005397_hematopoietic_system_phenotyp0.68307699
127MP0001545_abnormal_hematopoietic_system0.68307699
128MP0005390_skeleton_phenotype0.68073096
129MP0008469_abnormal_protein_level0.66848598
130MP0005167_abnormal_blood-brain_barrier0.66721258
131MP0002132_abnormal_respiratory_system0.66491333
132MP0003453_abnormal_keratinocyte_physiol0.66451870
133MP0002006_tumorigenesis0.66402100
134MP0002877_abnormal_melanocyte_morpholog0.65980238
135* MP0002405_respiratory_system_inflammati0.64188543
136MP0000685_abnormal_immune_system0.62473590
137MP0003111_abnormal_nucleus_morphology0.61483550
138MP0003656_abnormal_erythrocyte_physiolo0.60167855
139MP0004381_abnormal_hair_follicle0.57572941
140MP0005535_abnormal_body_temperature0.55254497
141* MP0000313_abnormal_cell_death0.54162286
142MP0002693_abnormal_pancreas_physiology0.51820441
143MP0006035_abnormal_mitochondrial_morpho0.49149899
144MP0002163_abnormal_gland_morphology0.48727947
145MP0003795_abnormal_bone_structure0.47870611
146MP0005647_abnormal_sex_gland0.47213843
147MP0001542_abnormal_bone_strength0.45841867
148MP0005164_abnormal_response_to0.45477593

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)6.24914224
2Acanthocytosis (HP:0001927)6.04686161
3Hypobetalipoproteinemia (HP:0003563)6.02090914
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.90056231
5Abnormality of proline metabolism (HP:0010907)4.83577908
6Hydroxyprolinuria (HP:0003080)4.83577908
7Agammaglobulinemia (HP:0004432)4.74634112
8Abnormality of liposaccharide metabolism (HP:0010968)4.61118703
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.61118703
10Abnormality of glycolipid metabolism (HP:0010969)4.61118703
11Stomatitis (HP:0010280)4.54249273
12Hypoproteinemia (HP:0003075)4.48568813
13Panhypogammaglobulinemia (HP:0003139)4.27512681
14Oral leukoplakia (HP:0002745)4.20104090
15Malnutrition (HP:0004395)4.05707822
16Mediastinal lymphadenopathy (HP:0100721)4.02068211
17Chronic diarrhea (HP:0002028)3.94627079
18Increased IgM level (HP:0003496)3.94178075
19Poikilocytosis (HP:0004447)3.92542577
20Right ventricular cardiomyopathy (HP:0011663)3.84007282
21Meningitis (HP:0001287)3.83594290
22Recurrent abscess formation (HP:0002722)3.78165959
23Increased mean platelet volume (HP:0011877)3.72471929
24Hypolipoproteinemia (HP:0010981)3.62221625
25Recurrent bacterial skin infections (HP:0005406)3.59404012
26Abnormal platelet volume (HP:0011876)3.58686628
27Orchitis (HP:0100796)3.45844159
28Conjugated hyperbilirubinemia (HP:0002908)3.44856634
29IgG deficiency (HP:0004315)3.44658543
30Retrobulbar optic neuritis (HP:0100654)3.43554347
31Optic neuritis (HP:0100653)3.43554347
32Abnormality of macrophages (HP:0004311)3.43072135
33Eczematoid dermatitis (HP:0000976)3.34622411
34Impaired platelet aggregation (HP:0003540)3.22643723
35Abnormal platelet function (HP:0011869)3.22643723
36Polycythemia (HP:0001901)3.22060197
37* Combined immunodeficiency (HP:0005387)3.21689176
38T lymphocytopenia (HP:0005403)3.16915342
39* Recurrent fungal infections (HP:0002841)3.16241697
40* Severe combined immunodeficiency (HP:0004430)3.14492671
41Pigmentary retinal degeneration (HP:0001146)3.12272572
42Chronic obstructive pulmonary disease (HP:0006510)3.08149896
43Obstructive lung disease (HP:0006536)3.08149896
44Increased cerebral lipofuscin (HP:0011813)3.07617486
45Loss of speech (HP:0002371)3.07538653
46Nonimmune hydrops fetalis (HP:0001790)3.01159479
47Abnormality of T cell number (HP:0011839)3.01021297
48Systemic lupus erythematosus (HP:0002725)3.00449489
49Vasculitis (HP:0002633)2.90730476
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.90084605
51Thrombocytosis (HP:0001894)2.88986381
52Abnormal glucose tolerance (HP:0001952)2.83079234
53Vacuolated lymphocytes (HP:0001922)2.80070196
54Myopathic facies (HP:0002058)2.80056954
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79043630
56Fat malabsorption (HP:0002630)2.78714310
57Colitis (HP:0002583)2.78363943
58Dysostosis multiplex (HP:0000943)2.77107190
59* Autoimmune thrombocytopenia (HP:0001973)2.75780047
60Reticulocytosis (HP:0001923)2.75347918
61Gastrointestinal dysmotility (HP:0002579)2.74367469
62Reduced antithrombin III activity (HP:0001976)2.68174997
63Keratoconjunctivitis sicca (HP:0001097)2.67211719
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.67036745
65Pustule (HP:0200039)2.65965180
66Abnormality of urine glucose concentration (HP:0011016)2.65751061
67Glycosuria (HP:0003076)2.65751061
68Acute lymphatic leukemia (HP:0006721)2.64358437
69Recurrent pneumonia (HP:0006532)2.58783287
70Abdominal distention (HP:0003270)2.56575052
71IgM deficiency (HP:0002850)2.50364281
72Dehydration (HP:0001944)2.48786741
73Abnormality of T cell physiology (HP:0011840)2.48458271
74Recurrent skin infections (HP:0001581)2.47442981
75* Autoimmune hemolytic anemia (HP:0001890)2.47291544
76Facial diplegia (HP:0001349)2.47044689
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46278536
78Pulmonary infiltrates (HP:0002113)2.46196882
79* Hypergammaglobulinemia (HP:0010702)2.45048730
80Petechiae (HP:0000967)2.44992477
81Keratoconjunctivitis (HP:0001096)2.44965483
82Abnormality of reticulocytes (HP:0004312)2.40278776
83Abnormality of the nasal mucosa (HP:0000433)2.39784967
84Elevated erythrocyte sedimentation rate (HP:0003565)2.38593187
85Hyperglycinuria (HP:0003108)2.37292580
86Increased serum ferritin (HP:0003281)2.37025109
87Inflammation of the large intestine (HP:0002037)2.35313827
88Abnormality of the prostate (HP:0008775)2.35031480
89Chronic mucocutaneous candidiasis (HP:0002728)2.34787211
90Recurrent cutaneous fungal infections (HP:0011370)2.34787211
91Recurrent gram-negative bacterial infections (HP:0005420)2.31222496
92Recurrent lower respiratory tract infections (HP:0002783)2.29888935
93Gastrointestinal inflammation (HP:0004386)2.27802936
94Woolly hair (HP:0002224)2.27604937
95* Sepsis (HP:0100806)2.27168764
96Urticaria (HP:0001025)2.25097438
97Disinhibition (HP:0000734)2.23275466
98* Granulocytopenia (HP:0001913)2.22653205
99Ragged-red muscle fibers (HP:0003200)2.22143052
100Hepatosplenomegaly (HP:0001433)2.21599637
101Mutism (HP:0002300)2.19420582
102Abnormality of the pleura (HP:0002103)2.18970488
103Abnormality of the gastric mucosa (HP:0004295)2.18750649
104Chronic otitis media (HP:0000389)2.18370906
105Prostate neoplasm (HP:0100787)2.17983999
106Hypertensive crisis (HP:0100735)2.17805076
107Purpura (HP:0000979)2.17313844
108Progressive neurologic deterioration (HP:0002344)2.15449772
109Encephalitis (HP:0002383)2.14845692
110Gangrene (HP:0100758)2.11056986
111Microretrognathia (HP:0000308)2.10949448
112* Leukocytosis (HP:0001974)2.10451099
113* Lymphoma (HP:0002665)2.09866577
114* Recurrent viral infections (HP:0004429)2.09481882
115Widely patent fontanelles and sutures (HP:0004492)2.09298385
116Cheilitis (HP:0100825)2.08940705
117Hypoplasia of the thymus (HP:0000778)2.08602687
118Hypercholesterolemia (HP:0003124)2.06535953
119Megaloblastic anemia (HP:0001889)2.06041566
120Pili torti (HP:0003777)2.05147122
121Nephrolithiasis (HP:0000787)2.04180024
122Polygenic inheritance (HP:0010982)2.02672011
123Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02601293
124Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00104673
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00104673
126Amaurosis fugax (HP:0100576)1.99758042
127Calcaneovalgus deformity (HP:0001848)1.98999656
128Basal ganglia calcification (HP:0002135)1.97862050
129Verrucae (HP:0200043)1.97236777
130Papilloma (HP:0012740)1.97236777
131Multiple enchondromatosis (HP:0005701)1.96976515
132* Lymphopenia (HP:0001888)1.96629915
133Hemoptysis (HP:0002105)1.96606654
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94777665
135Dicarboxylic aciduria (HP:0003215)1.94777665
136Nasal polyposis (HP:0100582)1.94491796
137Abnormality of lateral ventricle (HP:0030047)1.94459659
138Wide cranial sutures (HP:0010537)1.94283255
139Osteomyelitis (HP:0002754)1.93446852
1403-Methylglutaconic aciduria (HP:0003535)1.92891855
141Interstitial pulmonary disease (HP:0006530)1.92457240
142Rectal prolapse (HP:0002035)1.92128207
143Recurrent bronchitis (HP:0002837)1.91687320
144Xanthomatosis (HP:0000991)1.91354440
145Hypoalbuminemia (HP:0003073)1.90117852
146Abnormal albumin level (HP:0012116)1.90117852
147Gastrointestinal stroma tumor (HP:0100723)1.89030761
148Abnormality of T cells (HP:0002843)1.87134281
149Micronodular cirrhosis (HP:0001413)1.85584365
150Tongue fasciculations (HP:0001308)1.83171699
151Muscle fibrillation (HP:0010546)1.82825639
152Abnormality of the calcaneus (HP:0008364)1.82806543
153IgA deficiency (HP:0002720)1.82790217
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81647724
155Skin rash (HP:0000988)1.80845065
156Breast hypoplasia (HP:0003187)1.79484181
157Fatigue (HP:0012378)1.79044171
158Myositis (HP:0100614)1.78541592
159Increased connective tissue (HP:0009025)1.78489504
160Abnormal biliary tract morphology (HP:0012440)1.77936015
161Reticulocytopenia (HP:0001896)1.77933635
162Gingivitis (HP:0000230)1.77569884
163Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76902229
164* Abnormality of B cell number (HP:0010975)1.75344844
165* B lymphocytopenia (HP:0010976)1.75344844
166Villous atrophy (HP:0011473)1.74446332
167Abnormality of small intestinal villus morphology (HP:0011472)1.74446332
168Palpitations (HP:0001962)1.74299742
169Nausea (HP:0002018)1.74260507
170Spontaneous hematomas (HP:0007420)1.74075121
171Aplastic anemia (HP:0001915)1.71709477
172Cellulitis (HP:0100658)1.71415778
173Abnormality of the fingertips (HP:0001211)1.71158432
174Abnormality of purine metabolism (HP:0004352)1.70476078
175Macrocytic anemia (HP:0001972)1.69592308
176Alopecia of scalp (HP:0002293)1.68198418
177* Abnormality of eosinophils (HP:0001879)1.65862226
178Ulnar deviation of the wrist (HP:0003049)1.64973401
179Abnormality of nucleobase metabolism (HP:0010932)1.64729263
180Deformed tarsal bones (HP:0008119)1.64473168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.36523037
2MST44.06998835
3IRAK33.28857049
4GRK62.90193819
5MAP4K12.58482188
6VRK22.56468751
7ERN12.51039836
8MAP3K102.47118831
9TESK22.24982489
10TAOK22.22147271
11PRKG22.15497349
12STK102.14869521
13GRK72.14804870
14MST1R2.11528667
15LMTK22.02514708
16EPHA21.89164563
17IKBKB1.89014752
18AKT31.88268666
19RIPK41.80326854
20BCKDK1.79315074
21NME11.76184121
22PIM21.75570006
23PTK61.73842817
24TXK1.72119203
25SCYL21.70271257
26PDK21.66212143
27RIPK11.61206181
28BRSK21.58368427
29PRPF4B1.56431130
30TIE11.55119932
31TBK11.50850045
32PAK41.50374493
33BMPR21.43932194
34TEC1.42253625
35KDR1.40058385
36CDC71.39325935
37NUAK11.38334228
38TGFBR11.37002505
39MAP2K21.34984614
40TESK11.33891683
41LRRK21.30500609
42TGFBR21.30059467
43MAP3K111.29264366
44KIT1.26975788
45ARAF1.26800651
46WEE11.23745820
47MAP3K131.21813189
48MAP3K81.21181491
49BUB11.20029826
50MOS1.19421429
51NME21.18417162
52FES1.15780715
53PASK1.14400034
54EEF2K1.14249577
55TAOK31.13050344
56CSF1R1.12474429
57BTK1.07806617
58TTK1.06667528
59MATK1.05411357
60EIF2AK11.04835525
61ADRBK21.03841091
62FLT31.00909607
63RPS6KB21.00784753
64PKN20.98974185
65PRKCI0.93939609
66TTN0.93722521
67RPS6KA40.93124958
68VRK10.92159732
69DDR20.92005876
70SMG10.91049829
71ABL20.90411032
72CLK10.89758923
73CDK60.87609490
74IRAK40.87592992
75TYK20.86229856
76MAP2K30.84772243
77ACVR1B0.82615320
78AURKB0.81087342
79MAP3K60.79867052
80PIM10.78750324
81DAPK10.78694621
82EIF2AK30.76984636
83MAPKAPK30.76615882
84PIK3CG0.76520972
85BLK0.75417333
86HCK0.74368696
87FGR0.74247893
88MAP2K60.72331528
89NEK20.71738097
90TNK20.71284861
91TAOK10.70465243
92IKBKE0.69555933
93MAP3K50.66958646
94MAP3K30.66823802
95ITK0.66746812
96MAPK110.66431591
97CDK70.64251783
98SYK0.64063195
99ZAP700.63147714
100MAP3K70.62449696
101CSK0.60861741
102MAP3K10.59023803
103NEK10.57658733
104BRSK10.53959099
105TLK10.53014008
106IRAK20.52548218
107RPS6KA50.51808105
108EIF2AK20.51672337
109JAK30.51557154
110AKT20.51526210
111HIPK20.50950097
112MAPKAPK50.49781679
113MAPKAPK20.49497442
114DAPK30.48921506
115NEK90.48524920
116BRAF0.46491609
117EPHB20.46348179
118CDK120.46343356
119MAPK40.45617179
120PBK0.45586376
121IRAK10.44750148
122JAK10.44056645
123PRKCQ0.43728623
124LCK0.43556221
125CDC42BPA0.43335086
126ERBB20.43270587
127TAF10.43094847
128ATR0.43083987
129PLK10.42798289
130JAK20.42410079
131DYRK30.40871280
132ZAK0.40278338
133PLK40.38425023
134CCNB10.37916359
135FER0.37507345
136LYN0.36895079
137MAP3K20.36622552
138CDK40.36432662
139MAP3K140.35375916
140CHEK20.34695820
141NLK0.34483637
142STK40.34324215
143CDK90.33431608
144TRIB30.32997986
145BMX0.32966490
146CHUK0.32540980
147MARK30.29895680
148CSNK1G30.29675871
149AURKA0.28283428
150RPS6KL10.25749620
151RPS6KC10.25749620
152CDK140.24858917

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.36369770
2Renin-angiotensin system_Homo sapiens_hsa046144.39072699
3Vitamin digestion and absorption_Homo sapiens_hsa049774.25596148
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.09236196
5Mineral absorption_Homo sapiens_hsa049783.99686558
6Allograft rejection_Homo sapiens_hsa053303.35593848
7Asthma_Homo sapiens_hsa053103.27637518
8Caffeine metabolism_Homo sapiens_hsa002323.07098299
9Folate biosynthesis_Homo sapiens_hsa007903.05023139
10Graft-versus-host disease_Homo sapiens_hsa053323.02463105
11Galactose metabolism_Homo sapiens_hsa000522.96710067
12Autoimmune thyroid disease_Homo sapiens_hsa053202.79287264
13Starch and sucrose metabolism_Homo sapiens_hsa005002.52516293
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38275777
15Rheumatoid arthritis_Homo sapiens_hsa053232.23211785
16Protein digestion and absorption_Homo sapiens_hsa049742.22912848
17Type I diabetes mellitus_Homo sapiens_hsa049402.22789315
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18861627
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07461524
20Staphylococcus aureus infection_Homo sapiens_hsa051502.03979483
21DNA replication_Homo sapiens_hsa030302.03399433
22Osteoclast differentiation_Homo sapiens_hsa043802.02434563
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.74053907
24Malaria_Homo sapiens_hsa051441.73679555
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68869205
26Other glycan degradation_Homo sapiens_hsa005111.67185734
27Tuberculosis_Homo sapiens_hsa051521.61737698
28African trypanosomiasis_Homo sapiens_hsa051431.57585388
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53839860
30Viral myocarditis_Homo sapiens_hsa054161.52335364
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51008560
32TNF signaling pathway_Homo sapiens_hsa046681.49723698
33Systemic lupus erythematosus_Homo sapiens_hsa053221.45309777
34Fructose and mannose metabolism_Homo sapiens_hsa000511.43450590
35Bile secretion_Homo sapiens_hsa049761.36971534
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36698072
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34952820
38Glutathione metabolism_Homo sapiens_hsa004801.31430361
39Lysosome_Homo sapiens_hsa041421.28928614
40Mismatch repair_Homo sapiens_hsa034301.26468306
41Base excision repair_Homo sapiens_hsa034101.22420571
42T cell receptor signaling pathway_Homo sapiens_hsa046601.21746332
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19943233
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19172506
45Epstein-Barr virus infection_Homo sapiens_hsa051691.18768247
46Glycerolipid metabolism_Homo sapiens_hsa005611.18065190
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14272355
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13503580
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.11658500
50Histidine metabolism_Homo sapiens_hsa003401.06248391
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.05933757
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04155768
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04079669
54Sphingolipid metabolism_Homo sapiens_hsa006001.02231341
55* Primary immunodeficiency_Homo sapiens_hsa053400.97538978
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.96932679
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.96907275
58Acute myeloid leukemia_Homo sapiens_hsa052210.95916738
59Hematopoietic cell lineage_Homo sapiens_hsa046400.91917844
60Pentose phosphate pathway_Homo sapiens_hsa000300.91380135
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87660094
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85933151
63Ribosome_Homo sapiens_hsa030100.84929028
64Sulfur metabolism_Homo sapiens_hsa009200.84642153
65Thyroid cancer_Homo sapiens_hsa052160.84453510
66Pyrimidine metabolism_Homo sapiens_hsa002400.81327733
67Arachidonic acid metabolism_Homo sapiens_hsa005900.80955740
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.77318218
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76906234
70HTLV-I infection_Homo sapiens_hsa051660.76559723
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76545828
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76099116
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75168132
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73786529
75PPAR signaling pathway_Homo sapiens_hsa033200.72819830
76ABC transporters_Homo sapiens_hsa020100.71232206
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71148346
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68981104
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67208422
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66084845
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63919796
82Legionellosis_Homo sapiens_hsa051340.62346214
83Chemokine signaling pathway_Homo sapiens_hsa040620.62202155
84Phagosome_Homo sapiens_hsa041450.61525511
85* Purine metabolism_Homo sapiens_hsa002300.60069712
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59730744
87p53 signaling pathway_Homo sapiens_hsa041150.59129205
88Nucleotide excision repair_Homo sapiens_hsa034200.56259250
89Non-homologous end-joining_Homo sapiens_hsa034500.55270102
90Prion diseases_Homo sapiens_hsa050200.54620869
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54065613
92Homologous recombination_Homo sapiens_hsa034400.52814541
93Linoleic acid metabolism_Homo sapiens_hsa005910.50844657
94Cell cycle_Homo sapiens_hsa041100.49452991
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47209062
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46316808
97Carbon metabolism_Homo sapiens_hsa012000.45775988
98Leishmaniasis_Homo sapiens_hsa051400.45120294
99Thyroid hormone synthesis_Homo sapiens_hsa049180.44743265
100Parkinsons disease_Homo sapiens_hsa050120.44703022
101Oxidative phosphorylation_Homo sapiens_hsa001900.44000708
102Antigen processing and presentation_Homo sapiens_hsa046120.42184524
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41644218
104Apoptosis_Homo sapiens_hsa042100.41321787
105Arginine and proline metabolism_Homo sapiens_hsa003300.40939010
106B cell receptor signaling pathway_Homo sapiens_hsa046620.40787610
107Salmonella infection_Homo sapiens_hsa051320.36651561
108Fatty acid degradation_Homo sapiens_hsa000710.36631400
109Shigellosis_Homo sapiens_hsa051310.35959311
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.35437497
111RNA polymerase_Homo sapiens_hsa030200.35391030
112Pertussis_Homo sapiens_hsa051330.35197675
113Herpes simplex infection_Homo sapiens_hsa051680.34005522
114Influenza A_Homo sapiens_hsa051640.33506952
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33202585
116Fanconi anemia pathway_Homo sapiens_hsa034600.32317353
117Hepatitis C_Homo sapiens_hsa051600.31990592
118Biosynthesis of amino acids_Homo sapiens_hsa012300.31131760
119N-Glycan biosynthesis_Homo sapiens_hsa005100.30802524
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30494537
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30172631
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.30045256
123Arginine biosynthesis_Homo sapiens_hsa002200.29328007
124Pancreatic cancer_Homo sapiens_hsa052120.28596090
125Tryptophan metabolism_Homo sapiens_hsa003800.27875409
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27508422
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27508083
128Bladder cancer_Homo sapiens_hsa052190.26817861
129Chronic myeloid leukemia_Homo sapiens_hsa052200.25475908
130Toxoplasmosis_Homo sapiens_hsa051450.24330552
131Tight junction_Homo sapiens_hsa045300.23958800
132Spliceosome_Homo sapiens_hsa030400.23638872
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.22225198
134Platelet activation_Homo sapiens_hsa046110.21063356
135Adherens junction_Homo sapiens_hsa045200.20756515
136Proteasome_Homo sapiens_hsa030500.19998206
137Amoebiasis_Homo sapiens_hsa051460.19615334
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.19342664
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19190370
140Measles_Homo sapiens_hsa051620.18672197
141Hepatitis B_Homo sapiens_hsa051610.18412067
142Chemical carcinogenesis_Homo sapiens_hsa052040.18004627
143Viral carcinogenesis_Homo sapiens_hsa052030.17622231
144* Metabolic pathways_Homo sapiens_hsa011000.17112626
145VEGF signaling pathway_Homo sapiens_hsa043700.15494385
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14199630
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.12700051
148Non-small cell lung cancer_Homo sapiens_hsa052230.09511292
149Prolactin signaling pathway_Homo sapiens_hsa049170.09414971
150Alzheimers disease_Homo sapiens_hsa050100.08607532
151Collecting duct acid secretion_Homo sapiens_hsa049660.07468046

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