ACY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74955926
2L-phenylalanine metabolic process (GO:0006558)6.74955926
3L-phenylalanine catabolic process (GO:0006559)6.72422791
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.72422791
5lysine catabolic process (GO:0006554)6.50915469
6lysine metabolic process (GO:0006553)6.50915469
7glyoxylate metabolic process (GO:0046487)6.46559114
8cysteine metabolic process (GO:0006534)6.27687571
9aromatic amino acid family catabolic process (GO:0009074)6.24380662
10epoxygenase P450 pathway (GO:0019373)6.11681350
11urate metabolic process (GO:0046415)5.78476759
12tryptophan catabolic process (GO:0006569)5.77910665
13indole-containing compound catabolic process (GO:0042436)5.77910665
14indolalkylamine catabolic process (GO:0046218)5.77910665
15drug transmembrane transport (GO:0006855)5.72718943
16kynurenine metabolic process (GO:0070189)5.53285369
17serine family amino acid biosynthetic process (GO:0009070)5.43362883
18tryptophan metabolic process (GO:0006568)5.39759319
19very-low-density lipoprotein particle assembly (GO:0034379)5.36038914
20drug transport (GO:0015893)5.17388464
21serine family amino acid metabolic process (GO:0009069)5.17125807
22serine family amino acid catabolic process (GO:0009071)5.09449276
23aspartate family amino acid catabolic process (GO:0009068)5.05607288
24sulfur amino acid catabolic process (GO:0000098)5.02251602
25phospholipid efflux (GO:0033700)4.97913830
26NADH metabolic process (GO:0006734)4.81810330
27regulation of fibrinolysis (GO:0051917)4.76733915
28negative regulation of fibrinolysis (GO:0051918)4.72434543
29plasma lipoprotein particle assembly (GO:0034377)4.71582450
30aromatic amino acid family metabolic process (GO:0009072)4.60264860
31amino-acid betaine metabolic process (GO:0006577)4.59591863
32regulation of protein activation cascade (GO:2000257)4.56484324
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55735362
34glycine metabolic process (GO:0006544)4.52936488
35homocysteine metabolic process (GO:0050667)4.52096995
36short-chain fatty acid metabolic process (GO:0046459)4.44230675
37bile acid biosynthetic process (GO:0006699)4.43674919
38alpha-amino acid catabolic process (GO:1901606)4.43534154
39omega-hydroxylase P450 pathway (GO:0097267)4.41706415
40cellular modified amino acid catabolic process (GO:0042219)4.41439331
41protein-lipid complex remodeling (GO:0034368)4.38739340
42macromolecular complex remodeling (GO:0034367)4.38739340
43plasma lipoprotein particle remodeling (GO:0034369)4.38739340
44proline metabolic process (GO:0006560)4.34773734
45cellular ketone body metabolic process (GO:0046950)4.34177350
46cellular amino acid catabolic process (GO:0009063)4.31292799
47acetyl-CoA metabolic process (GO:0006084)4.29651851
48complement activation, alternative pathway (GO:0006957)4.29351320
49glutamate metabolic process (GO:0006536)4.28529779
50drug catabolic process (GO:0042737)4.27985976
51regulation of complement activation (GO:0030449)4.24886112
52positive regulation of lipoprotein lipase activity (GO:0051006)4.23959004
53positive regulation of triglyceride lipase activity (GO:0061365)4.23959004
54response to mercury ion (GO:0046689)4.22321788
552-oxoglutarate metabolic process (GO:0006103)4.20783947
56fat-soluble vitamin biosynthetic process (GO:0042362)4.19452084
57cholesterol efflux (GO:0033344)4.18755665
58protein-lipid complex assembly (GO:0065005)4.15812529
59L-serine metabolic process (GO:0006563)4.13702223
60oxaloacetate metabolic process (GO:0006107)4.11978782
61intestinal absorption (GO:0050892)4.11110318
62alpha-linolenic acid metabolic process (GO:0036109)4.09132449
63amine catabolic process (GO:0009310)4.06838051
64cellular biogenic amine catabolic process (GO:0042402)4.06838051
65branched-chain amino acid metabolic process (GO:0009081)4.04619460
66organic cation transport (GO:0015695)4.03777849
67bile acid and bile salt transport (GO:0015721)4.03270717
68aldehyde catabolic process (GO:0046185)4.02798784
69arginine metabolic process (GO:0006525)4.01417630
70indolalkylamine metabolic process (GO:0006586)4.00170636
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96796423
72branched-chain amino acid catabolic process (GO:0009083)3.95317955
73intestinal cholesterol absorption (GO:0030299)3.95280924
74fibrinolysis (GO:0042730)3.94320637
75valine metabolic process (GO:0006573)3.94124582
76proline biosynthetic process (GO:0006561)3.88355277
77heme transport (GO:0015886)3.87456713
78reverse cholesterol transport (GO:0043691)3.87026692
79phosphate ion transport (GO:0006817)3.86278428
80fatty acid beta-oxidation (GO:0006635)3.85988927
81angiotensin maturation (GO:0002003)3.83511034
82carnitine metabolic process (GO:0009437)3.81813584
83glutamine family amino acid biosynthetic process (GO:0009084)3.81137143
84organic acid catabolic process (GO:0016054)3.80712408
85carboxylic acid catabolic process (GO:0046395)3.80712408
86bile acid metabolic process (GO:0008206)3.78920738
87phosphate ion transmembrane transport (GO:0035435)3.76491192
88ketone body metabolic process (GO:1902224)3.73013221
89benzene-containing compound metabolic process (GO:0042537)3.72151645
90plasma lipoprotein particle organization (GO:0071827)3.71427962
91fatty acid oxidation (GO:0019395)3.70517353
92urea metabolic process (GO:0019627)3.69675873
93urea cycle (GO:0000050)3.69675873
94blood coagulation, intrinsic pathway (GO:0007597)3.69438942
95triglyceride homeostasis (GO:0070328)3.68133761
96acylglycerol homeostasis (GO:0055090)3.68133761
97exogenous drug catabolic process (GO:0042738)3.67495621
98tricarboxylic acid metabolic process (GO:0072350)3.66067865
99phenylpropanoid metabolic process (GO:0009698)3.65453801
100regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.64938659
101ethanol oxidation (GO:0006069)3.63984496
102lipid oxidation (GO:0034440)3.63760937
103nonribosomal peptide biosynthetic process (GO:0019184)3.62406082
104alkaloid metabolic process (GO:0009820)3.61699315
105ethanol metabolic process (GO:0006067)3.61222676
106nitrogen cycle metabolic process (GO:0071941)3.59745178
107tyrosine metabolic process (GO:0006570)3.58642965
108regulation of bile acid biosynthetic process (GO:0070857)3.57158152
109negative regulation of lipase activity (GO:0060192)3.56451048
110hormone catabolic process (GO:0042447)3.54567559
111coenzyme catabolic process (GO:0009109)3.53669428
112oxidative demethylation (GO:0070989)3.53092178
113fatty acid catabolic process (GO:0009062)3.52146148
114plasma lipoprotein particle clearance (GO:0034381)3.51795555
115glutathione biosynthetic process (GO:0006750)3.50797718
116regulation of plasminogen activation (GO:0010755)3.50053961
117protein-lipid complex subunit organization (GO:0071825)3.47077974
118drug metabolic process (GO:0017144)3.46776479
119cellular glucuronidation (GO:0052695)3.46697605
120very long-chain fatty acid metabolic process (GO:0000038)3.45682023
121monocarboxylic acid catabolic process (GO:0072329)3.45336842
122aminoglycoside antibiotic metabolic process (GO:0030647)3.43379493
123negative regulation of hemostasis (GO:1900047)3.43186868
124negative regulation of blood coagulation (GO:0030195)3.43186868
125regulation of cholesterol esterification (GO:0010872)3.42929334
126negative regulation of cholesterol transport (GO:0032375)3.41554843
127negative regulation of sterol transport (GO:0032372)3.41554843
128lipoprotein metabolic process (GO:0042157)3.41295508
129cholesterol homeostasis (GO:0042632)3.38897776
130sulfur amino acid metabolic process (GO:0000096)3.38227385
131L-ascorbic acid metabolic process (GO:0019852)3.37978159
132dicarboxylic acid metabolic process (GO:0043648)3.36883707
133flavonoid metabolic process (GO:0009812)3.33091433
134sterol homeostasis (GO:0055092)3.32614184
135quaternary ammonium group transport (GO:0015697)3.30595192
136response to phenylpropanoid (GO:0080184)3.30531510
137glutathione derivative metabolic process (GO:1901685)3.29037853
138glutathione derivative biosynthetic process (GO:1901687)3.29037853
139small molecule catabolic process (GO:0044282)3.28298689
140high-density lipoprotein particle remodeling (GO:0034375)3.28137094
141aspartate family amino acid metabolic process (GO:0009066)3.24393022
142uronic acid metabolic process (GO:0006063)3.23650890
143glucuronate metabolic process (GO:0019585)3.23650890
144negative regulation of coagulation (GO:0050819)3.21767190
145positive regulation of fatty acid biosynthetic process (GO:0045723)3.20055116
146fructose metabolic process (GO:0006000)3.19942184
147acyl-CoA metabolic process (GO:0006637)3.18811828
148thioester metabolic process (GO:0035383)3.18811828
149positive regulation of lipid catabolic process (GO:0050996)3.18312335
150protein carboxylation (GO:0018214)3.15820322
151peptidyl-glutamic acid carboxylation (GO:0017187)3.15820322
152vitamin biosynthetic process (GO:0009110)3.15134827
153regulation of triglyceride catabolic process (GO:0010896)3.13673892
154glutathione metabolic process (GO:0006749)3.13331939
155low-density lipoprotein particle remodeling (GO:0034374)3.10151428
156doxorubicin metabolic process (GO:0044598)3.08497128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.89906444
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.58403660
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.92108148
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.18655550
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15663123
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.97237906
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.67638858
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.49307799
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91430806
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.78004469
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45036399
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.37355594
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.34649362
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24164346
15E2F7_22180533_ChIP-Seq_HELA_Human2.12619928
16AR_21909140_ChIP-Seq_LNCAP_Human1.96500948
17ZNF263_19887448_ChIP-Seq_K562_Human1.95510810
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95060067
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93756062
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93671678
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93071413
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88150734
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86672663
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77411144
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.73497516
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68882993
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64080212
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61764420
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53163211
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50907064
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.50720042
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50602297
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.48876744
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45646468
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.39905482
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39455148
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33494508
38* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32425451
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31640050
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30935878
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30141778
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29794272
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.28338609
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27618606
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27397397
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27254075
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.23257829
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22552650
49XRN2_22483619_ChIP-Seq_HELA_Human1.19206576
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18283073
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16171927
52CLOCK_20551151_ChIP-Seq_293T_Human1.15177765
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15072567
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14295503
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13952369
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11105793
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10288086
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10197877
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.09670936
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07705801
61P68_20966046_ChIP-Seq_HELA_Human1.07397232
62BCL6_27268052_Chip-Seq_Bcells_Human1.07183042
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06791711
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05897969
65DCP1A_22483619_ChIP-Seq_HELA_Human1.05734040
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.05729841
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04224434
68E2F1_20622854_ChIP-Seq_HELA_Human1.02034382
69SA1_27219007_Chip-Seq_Bcells_Human1.01273477
70PHF8_20622854_ChIP-Seq_HELA_Human0.99930110
71GABP_19822575_ChIP-Seq_HepG2_Human0.99607196
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99095189
73THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95297903
74OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94704613
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94085577
76YY1_21170310_ChIP-Seq_MESCs_Mouse0.93681968
77FOXA2_19822575_ChIP-Seq_HepG2_Human0.92780198
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92686288
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92094833
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91557045
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90903927
82* LXR_22292898_ChIP-Seq_THP-1_Human0.89838045
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89367825
84CTCF_20526341_ChIP-Seq_ESCs_Human0.88689972
85GATA4_25053715_ChIP-Seq_YYC3_Human0.87530661
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87210806
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86799218
88FOXP3_21729870_ChIP-Seq_TREG_Human0.86503569
89SOX2_20726797_ChIP-Seq_SW620_Human0.86448847
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86427982
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86284516
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86078603
93NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85774406
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85519765
95KDM5A_27292631_Chip-Seq_BREAST_Human0.84976924
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84672182
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84570728
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84264379
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84024798
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83407848
101* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83158557
102* VDR_21846776_ChIP-Seq_THP-1_Human0.82974964
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82949667
104* TET1_21451524_ChIP-Seq_MESCs_Mouse0.82460240
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82426236
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81721836
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.81410616
108* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81351927
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81117362
110BCOR_27268052_Chip-Seq_Bcells_Human0.80894706
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80140716
112P53_21459846_ChIP-Seq_SAOS-2_Human0.79810708
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79586093
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77961704
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77602085
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77092262
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76361552
118VDR_23849224_ChIP-Seq_CD4+_Human0.75850988
119* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75668856
120RACK7_27058665_Chip-Seq_MCF-7_Human0.74475999
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74302189
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.72768046
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.72341669
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72292484
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.72287727
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71877080
127GATA6_25053715_ChIP-Seq_YYC3_Human0.71655965
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71573233
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.71246647
130SOX2_18692474_ChIP-Seq_MESCs_Mouse0.71136977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.50530326
2MP0002139_abnormal_hepatobiliary_system6.65438884
3MP0003806_abnormal_nucleotide_metabolis5.03837884
4MP0005085_abnormal_gallbladder_physiolo4.68814323
5MP0005365_abnormal_bile_salt4.54103902
6MP0008875_abnormal_xenobiotic_pharmacok4.32060077
7MP0005332_abnormal_amino_acid4.03153067
8MP0003195_calcinosis3.33714587
9MP0004043_abnormal_pH_regulation3.25460615
10MP0004019_abnormal_vitamin_homeostasis3.24355353
11MP0003252_abnormal_bile_duct2.92837062
12MP0009840_abnormal_foam_cell2.85964549
13MP0009643_abnormal_urine_homeostasis2.56349081
14MP0001666_abnormal_nutrient_absorption2.46090817
15MP0010329_abnormal_lipoprotein_level2.38855633
16MP0003186_abnormal_redox_activity2.21376186
17MP0003191_abnormal_cellular_cholesterol2.02857321
18MP0002138_abnormal_hepatobiliary_system1.95601974
19MP0005636_abnormal_mineral_homeostasis1.88544806
20MP0001764_abnormal_homeostasis1.88438324
21MP0005584_abnormal_enzyme/coenzyme_acti1.81084460
22MP0005319_abnormal_enzyme/_coenzyme1.79612465
23MP0005083_abnormal_biliary_tract1.75159082
24MP0006036_abnormal_mitochondrial_physio1.70080337
25MP0002118_abnormal_lipid_homeostasis1.67925846
26MP0000609_abnormal_liver_physiology1.64061167
27MP0005451_abnormal_body_composition1.59388292
28MP0001756_abnormal_urination1.56838684
29MP0002136_abnormal_kidney_physiology1.46830278
30MP0001765_abnormal_ion_homeostasis1.38764905
31MP0005058_abnormal_lysosome_morphology1.37451373
32MP0003656_abnormal_erythrocyte_physiolo1.20512316
33MP0003183_abnormal_peptide_metabolism1.19903500
34MP0000372_irregular_coat_pigmentation1.16076693
35MP0005377_hearing/vestibular/ear_phenot1.11775716
36MP0003878_abnormal_ear_physiology1.11775716
37MP0004147_increased_porphyrin_level1.10518881
38MP0000598_abnormal_liver_morphology1.09445687
39MP0006035_abnormal_mitochondrial_morpho1.05742238
40MP0010234_abnormal_vibrissa_follicle1.04371596
41MP0003868_abnormal_feces_composition1.02042310
42MP0005266_abnormal_metabolism0.92941079
43MP0004264_abnormal_extraembryonic_tissu0.92296652
44MP0003718_maternal_effect0.92052951
45MP0002132_abnormal_respiratory_system0.91065152
46MP0001661_extended_life_span0.89264624
47MP0005376_homeostasis/metabolism_phenot0.86332126
48MP0009379_abnormal_foot_pigmentation0.86197310
49MP0003638_abnormal_response/metabolism_0.86011689
50MP0009642_abnormal_blood_homeostasis0.84947828
51MP0008469_abnormal_protein_level0.83723652
52MP0002876_abnormal_thyroid_physiology0.82979684
53MP0005084_abnormal_gallbladder_morpholo0.82654445
54MP0009765_abnormal_xenobiotic_induced0.82154553
55MP0000604_amyloidosis0.81936491
56MP0003693_abnormal_embryo_hatching0.81313564
57MP0003011_delayed_dark_adaptation0.75707935
58MP0009763_increased_sensitivity_to0.75233232
59MP0003879_abnormal_hair_cell0.73938067
60MP0003329_amyloid_beta_deposits0.72573844
61MP0003690_abnormal_glial_cell0.71624533
62MP0000678_abnormal_parathyroid_gland0.69035397
63MP0000920_abnormal_myelination0.68791283
64MP0009697_abnormal_copulation0.66848467
65MP0010155_abnormal_intestine_physiology0.66597080
66MP0005670_abnormal_white_adipose0.66419667
67MP0000538_abnormal_urinary_bladder0.65734574
68MP0008873_increased_physiological_sensi0.64255630
69MP0005408_hypopigmentation0.64135314
70MP0005220_abnormal_exocrine_pancreas0.62655929
71MP0003941_abnormal_skin_development0.62603231
72MP0005395_other_phenotype0.61784616
73MP0004782_abnormal_surfactant_physiolog0.60107974
74MP0005448_abnormal_energy_balance0.59615922
75MP0004885_abnormal_endolymph0.57025641
76MP0002135_abnormal_kidney_morphology0.56650598
77MP0004858_abnormal_nervous_system0.56423500
78MP0005075_abnormal_melanosome_morpholog0.55567874
79MP0009764_decreased_sensitivity_to0.54632375
80MP0005501_abnormal_skin_physiology0.54309827
81MP0001881_abnormal_mammary_gland0.53376368
82MP0005647_abnormal_sex_gland0.53339321
83MP0005535_abnormal_body_temperature0.52577936
84MP0005166_decreased_susceptibility_to0.51862314
85MP0004133_heterotaxia0.51745722
86MP0009115_abnormal_fat_cell0.51547328
87MP0001664_abnormal_digestion0.51304559
88MP0002796_impaired_skin_barrier0.51242905
89MP0000566_synostosis0.50181029
90MP0005334_abnormal_fat_pad0.49247508
91MP0005330_cardiomyopathy0.49166627
92MP0002078_abnormal_glucose_homeostasis0.47903408
93MP0003315_abnormal_perineum_morphology0.47776895
94MP0000230_abnormal_systemic_arterial0.47260439
95MP0002970_abnormal_white_adipose0.46918418
96MP0005666_abnormal_adipose_tissue0.46622891
97MP0004957_abnormal_blastocyst_morpholog0.45714375
98MP0004142_abnormal_muscle_tone0.45117295
99MP0009053_abnormal_anal_canal0.45034921
100MP0009672_abnormal_birth_weight0.44120932
101MP0006082_CNS_inflammation0.42726223
102MP0000490_abnormal_crypts_of0.42626103
103MP0003172_abnormal_lysosome_physiology0.42466147
104MP0002938_white_spotting0.41872718
105MP0000371_diluted_coat_color0.39260261
106MP0000747_muscle_weakness0.39213566
107MP0002089_abnormal_postnatal_growth/wei0.39047490
108MP0004272_abnormal_basement_membrane0.38474487
109MP0000467_abnormal_esophagus_morphology0.37539877
110MP0001663_abnormal_digestive_system0.37075641
111MP0001873_stomach_inflammation0.36827946
112MP0005023_abnormal_wound_healing0.36625060
113MP0002254_reproductive_system_inflammat0.36184469
114MP0001730_embryonic_growth_arrest0.33911557
115MP0001845_abnormal_inflammatory_respons0.33402421
116MP0001958_emphysema0.33368006
117MP0002396_abnormal_hematopoietic_system0.32992401
118MP0003075_altered_response_to0.32719677
119MP0003221_abnormal_cardiomyocyte_apopto0.30068442
120MP0000358_abnormal_cell_content/0.29876229
121MP0003724_increased_susceptibility_to0.29677210
122MP0005464_abnormal_platelet_physiology0.29656578
123MP0008872_abnormal_physiological_respon0.28402971
124MP0002971_abnormal_brown_adipose0.27643829
125MP0001293_anophthalmia0.27191931
126MP0002168_other_aberrant_phenotype0.26817732
127MP0000477_abnormal_intestine_morphology0.26577054
128MP0002269_muscular_atrophy0.26485130
129MP0003953_abnormal_hormone_level0.26155056
130MP0010094_abnormal_chromosome_stability0.25231405
131MP0003959_abnormal_lean_body0.24491972
132MP0000462_abnormal_digestive_system0.24008595

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.67884141
2Hyperglycinuria (HP:0003108)5.28457467
3Abnormality of glutamine family amino acid metabolism (HP:0010902)4.99432006
4Abnormality of glycine metabolism (HP:0010895)4.96706019
5Abnormality of serine family amino acid metabolism (HP:0010894)4.96706019
6Gout (HP:0001997)4.75512099
7Intrahepatic cholestasis (HP:0001406)4.65741841
8Systemic lupus erythematosus (HP:0002725)4.59248915
9Abnormality of aspartate family amino acid metabolism (HP:0010899)4.37853834
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.32585630
11Ketosis (HP:0001946)4.30525646
12Hyperammonemia (HP:0001987)4.23148984
13Xanthomatosis (HP:0000991)4.05525741
14Abnormality of fatty-acid metabolism (HP:0004359)4.03462168
15Abnormality of complement system (HP:0005339)3.99299306
16Hyperglycinemia (HP:0002154)3.97438488
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.97352940
18Proximal tubulopathy (HP:0000114)3.83968188
19Hypobetalipoproteinemia (HP:0003563)3.83891791
20Ketoacidosis (HP:0001993)3.79274927
21Abnormality of purine metabolism (HP:0004352)3.72356914
22Metabolic alkalosis (HP:0200114)3.71644027
23Hypomagnesemia (HP:0002917)3.69037561
24Increased circulating renin level (HP:0000848)3.66000353
25Hypokalemic alkalosis (HP:0001949)3.64440291
26Deep venous thrombosis (HP:0002625)3.59988355
27Abnormality of nucleobase metabolism (HP:0010932)3.55566626
28Hyperuricemia (HP:0002149)3.55471175
29Increased purine levels (HP:0004368)3.55471175
30Generalized aminoaciduria (HP:0002909)3.45779007
31Glomerulonephritis (HP:0000099)3.38101917
32Alkalosis (HP:0001948)3.36449498
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.33056946
34Dicarboxylic aciduria (HP:0003215)3.33056946
35Abnormal urine output (HP:0012590)3.32860966
36Polyuria (HP:0000103)3.23485152
37Prolonged partial thromboplastin time (HP:0003645)3.22158867
38Abnormality of pyrimidine metabolism (HP:0004353)3.21986049
39Abnormality of magnesium homeostasis (HP:0004921)3.19694146
40Hyperactive renin-angiotensin system (HP:0000841)3.18247813
41Glycosuria (HP:0003076)3.17285130
42Abnormality of urine glucose concentration (HP:0011016)3.17285130
43Abnormality of methionine metabolism (HP:0010901)3.13651044
44Lethargy (HP:0001254)3.11704135
45Metabolic acidosis (HP:0001942)3.06840634
46Hyperlipoproteinemia (HP:0010980)3.02414787
47Abnormality of renal excretion (HP:0011036)3.00822809
48Abnormality of chloride homeostasis (HP:0011422)2.94466722
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93519886
50Spontaneous abortion (HP:0005268)2.90837035
51Cholecystitis (HP:0001082)2.89950690
52Abnormal gallbladder physiology (HP:0012438)2.89950690
53Reduced antithrombin III activity (HP:0001976)2.88308914
54Fat malabsorption (HP:0002630)2.87094207
55Hypoglycemic coma (HP:0001325)2.82341196
56Cerebral edema (HP:0002181)2.78000142
57Abnormality of serum amino acid levels (HP:0003112)2.77543995
58Hemorrhage of the eye (HP:0011885)2.73895973
59Vomiting (HP:0002013)2.72064461
60Joint hemorrhage (HP:0005261)2.69616777
61* Delayed CNS myelination (HP:0002188)2.69061045
62Malnutrition (HP:0004395)2.63994244
63Vascular calcification (HP:0004934)2.62753474
64Increased serum pyruvate (HP:0003542)2.62513806
65Abnormality of glycolysis (HP:0004366)2.62513806
66Ileus (HP:0002595)2.59794515
67Abnormality of vitamin metabolism (HP:0100508)2.59607516
68Hyperphosphaturia (HP:0003109)2.59271696
69Hypolipoproteinemia (HP:0010981)2.57652762
70Renal salt wasting (HP:0000127)2.57487075
71Hyperbilirubinemia (HP:0002904)2.56686213
72Hypoalphalipoproteinemia (HP:0003233)2.52452506
73Irritability (HP:0000737)2.50819593
74Hydroxyprolinuria (HP:0003080)2.49355537
75Abnormality of proline metabolism (HP:0010907)2.49355537
76Spastic diplegia (HP:0001264)2.49093006
77Acanthocytosis (HP:0001927)2.48325496
78Abnormal drinking behavior (HP:0030082)2.47561529
79Polydipsia (HP:0001959)2.47561529
80Opisthotonus (HP:0002179)2.43097738
81Cerebral palsy (HP:0100021)2.40531236
82Confusion (HP:0001289)2.40200061
83Abnormality of the intrinsic pathway (HP:0010989)2.38840541
84Nephritis (HP:0000123)2.38481348
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38074079
86Abnormal urine phosphate concentration (HP:0012599)2.36433663
87Rickets (HP:0002748)2.32570502
88Hepatic necrosis (HP:0002605)2.32074791
89Abnormal enzyme/coenzyme activity (HP:0012379)2.31775161
90Methylmalonic aciduria (HP:0012120)2.30946874
91Nephrolithiasis (HP:0000787)2.26934960
92Megaloblastic anemia (HP:0001889)2.25482195
93Steatorrhea (HP:0002570)2.24313859
94Renal tubular acidosis (HP:0001947)2.23935872
95Cardiovascular calcification (HP:0011915)2.23010380
96Nausea (HP:0002018)2.22086553
97Epidermoid cyst (HP:0200040)2.20798057
98Tetany (HP:0001281)2.20440093
99Abnormality of the vitamin B12 metabolism (HP:0004341)2.18633497
100Abnormality of the common coagulation pathway (HP:0010990)2.17766229
101Abnormality of alkaline phosphatase activity (HP:0004379)2.16917230
102Hyperaldosteronism (HP:0000859)2.12645449
103Cholelithiasis (HP:0001081)2.07224077
104Enlarged kidneys (HP:0000105)2.06347568
105Hypercholesterolemia (HP:0003124)2.05082429
106Widely patent fontanelles and sutures (HP:0004492)2.04496317
107Hepatocellular carcinoma (HP:0001402)2.04446824
108Late onset (HP:0003584)2.04043341
109Abnormality of vitamin B metabolism (HP:0004340)2.03507846
110Abnormality of renin-angiotensin system (HP:0000847)2.02026381
111Spastic paraparesis (HP:0002313)2.01589416
112Hypophosphatemic rickets (HP:0004912)1.99728849
113Hepatocellular necrosis (HP:0001404)1.98650505
114Conjugated hyperbilirubinemia (HP:0002908)1.96964388
115Hypercalciuria (HP:0002150)1.96476590
116Neonatal onset (HP:0003623)1.95450833
117Elevated alkaline phosphatase (HP:0003155)1.94027217
118Abnormal gallbladder morphology (HP:0012437)1.93194828
119* Acute encephalopathy (HP:0006846)1.91667548
120Complement deficiency (HP:0004431)1.91358654
121Vacuolated lymphocytes (HP:0001922)1.91331287
122Renal tubular dysfunction (HP:0000124)1.90486249
123Abnormal tarsal ossification (HP:0008369)1.89264198
124Rhabdomyolysis (HP:0003201)1.88979517
125Hypophosphatemia (HP:0002148)1.87458842
126Type I transferrin isoform profile (HP:0003642)1.82562317
127Abnormal mitochondria in muscle tissue (HP:0008316)1.82103703
128CNS demyelination (HP:0007305)1.81162103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.54595434
2WNK35.36935829
3OXSR15.01359645
4WNK44.91880444
5EPHA23.33321271
6VRK23.14567665
7STK392.69534796
8NEK12.28663745
9STK161.98956321
10MAPKAPK31.97368999
11EPHB11.94554637
12ERN11.91813790
13PBK1.83770301
14TESK21.81447101
15BUB11.77788842
16NME11.75462666
17MET1.66406454
18NME21.63241986
19MAP3K121.59894071
20WEE11.57839608
21SMG11.54370428
22RIPK11.52086312
23GRK61.50263346
24FGFR41.48154645
25AKT31.46241425
26FLT31.41432205
27PINK11.41309369
28PRKG21.41048153
29EIF2AK11.40569198
30MAPK111.36082356
31LMTK21.34379574
32MUSK1.34344164
33MST41.26912989
34INSRR1.22710301
35ABL21.20429397
36EIF2AK31.20051204
37SIK11.12091149
38STK101.11647956
39MAP3K111.11477513
40LRRK21.08100909
41EEF2K1.08005772
42MST1R1.00545437
43TTK0.96948077
44MAP3K80.96851433
45ICK0.94288060
46TLK10.94049105
47MYLK0.92405878
48DAPK10.90132356
49MAP2K20.89909395
50MAP3K20.89714398
51TESK10.88688888
52PDK40.88245362
53PDK30.88245362
54PIM20.87047824
55MAP3K30.86944961
56PAK40.84312328
57MAPK150.84138549
58KDR0.82730819
59ARAF0.80879291
60FER0.78695245
61ILK0.77480119
62ACVR1B0.77151291
63GSK3A0.76521008
64STK38L0.76137479
65CDK70.72946475
66ERBB40.69294188
67CSF1R0.68244259
68MAP2K30.68148964
69SGK2230.66368780
70SGK4940.66368780
71SCYL20.65191043
72DYRK30.65029196
73PDK20.65008198
74TBK10.64703273
75WNK10.64231048
76GRK10.62560357
77STK40.62163920
78VRK10.61780044
79MAP4K10.61298526
80AURKA0.61297049
81MAP2K60.61143583
82PRKCI0.60128290
83DAPK30.59364737
84ZAK0.59046279
85PIK3CA0.58672033
86BRSK20.57882374
87RPS6KB20.56595720
88CSNK1G30.55794410
89MATK0.55232852
90CDC70.54715712
91DYRK1B0.53269255
92PIM10.53095225
93NUAK10.53003620
94MAPK40.52125838
95CSNK1G10.51425915
96PKN20.50840851
97BRSK10.50764572
98KIT0.50018708
99MAPKAPK50.49987151
100TYK20.49242756
101CSK0.48094711
102CDK40.47653129
103AKT20.47407356
104BRAF0.43973964
105BTK0.43029878
106CSNK2A20.41997034
107PLK10.41811775
108CAMK2G0.40938004
109PIK3CG0.40221035
110CDK80.39572885
111ERBB20.39402930
112TRIB30.38920855
113PTK60.38332025
114MAP3K10.37388947
115MAP3K100.37319577
116BMX0.35304977
117PRKACG0.33864506
118CSNK2A10.33682698
119IRAK30.33654437
120SRPK10.33175155
121CSNK1A10.32028608
122AURKB0.31124660
123PRKCD0.30881993
124PAK10.30799069
125MKNK10.30589157
126PRKAA20.30426741
127PTK20.29190666
128PRKCA0.29024566
129CLK10.29001839
130PDPK10.28878710
131MTOR0.27102964
132PRKAA10.25236444
133JAK20.25167242
134CSNK1E0.25012902
135TSSK60.24516829
136ATR0.23674526
137NEK20.23656982
138TAOK20.23612082
139UHMK10.23028354
140IGF1R0.22786514
141CSNK1A1L0.22586043

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08137800
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.02326537
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78135136
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.76695721
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.72756345
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64228334
7Butanoate metabolism_Homo sapiens_hsa006502.57837573
8Nitrogen metabolism_Homo sapiens_hsa009102.54511358
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45430755
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.44735926
11Tryptophan metabolism_Homo sapiens_hsa003802.42795693
12Propanoate metabolism_Homo sapiens_hsa006402.38257586
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33187488
14Fatty acid degradation_Homo sapiens_hsa000712.31624038
15* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30172122
16Peroxisome_Homo sapiens_hsa041462.28599448
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15420128
18* Arginine biosynthesis_Homo sapiens_hsa002201.89736998
19Folate biosynthesis_Homo sapiens_hsa007901.88094109
20Pyruvate metabolism_Homo sapiens_hsa006201.81515156
21Fatty acid metabolism_Homo sapiens_hsa012121.80194219
22Fatty acid elongation_Homo sapiens_hsa000621.75139192
23beta-Alanine metabolism_Homo sapiens_hsa004101.74109448
24Histidine metabolism_Homo sapiens_hsa003401.71400505
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63359190
26Selenocompound metabolism_Homo sapiens_hsa004501.63255947
27Carbon metabolism_Homo sapiens_hsa012001.61676715
28* Biosynthesis of amino acids_Homo sapiens_hsa012301.61165012
29Vitamin digestion and absorption_Homo sapiens_hsa049771.59168259
30Arginine and proline metabolism_Homo sapiens_hsa003301.58017340
31Sulfur metabolism_Homo sapiens_hsa009201.57806431
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.54827643
33Glutathione metabolism_Homo sapiens_hsa004801.52515554
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52034069
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.47614231
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46896685
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46351885
38Chemical carcinogenesis_Homo sapiens_hsa052041.43875167
39Steroid biosynthesis_Homo sapiens_hsa001001.43470983
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43333502
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40645842
42PPAR signaling pathway_Homo sapiens_hsa033201.38061515
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35857195
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.32799463
45Sulfur relay system_Homo sapiens_hsa041221.32290619
46Bile secretion_Homo sapiens_hsa049761.31323123
47One carbon pool by folate_Homo sapiens_hsa006701.20469498
48Complement and coagulation cascades_Homo sapiens_hsa046101.20312206
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16798004
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15341347
51Starch and sucrose metabolism_Homo sapiens_hsa005001.11852649
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11484348
53Retinol metabolism_Homo sapiens_hsa008301.08181332
54Pentose phosphate pathway_Homo sapiens_hsa000301.03477882
55Phenylalanine metabolism_Homo sapiens_hsa003600.99547421
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98517470
57Lysine degradation_Homo sapiens_hsa003100.96083734
58Fat digestion and absorption_Homo sapiens_hsa049750.95073745
59Vitamin B6 metabolism_Homo sapiens_hsa007500.90495338
60Tyrosine metabolism_Homo sapiens_hsa003500.89043941
61Caffeine metabolism_Homo sapiens_hsa002320.84178579
62Fructose and mannose metabolism_Homo sapiens_hsa000510.80223908
63* Metabolic pathways_Homo sapiens_hsa011000.75057925
64Glycerolipid metabolism_Homo sapiens_hsa005610.71622920
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70777248
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.70347014
67ABC transporters_Homo sapiens_hsa020100.67408833
68DNA replication_Homo sapiens_hsa030300.65956375
69Oxidative phosphorylation_Homo sapiens_hsa001900.55508079
70Staphylococcus aureus infection_Homo sapiens_hsa051500.53394143
71Mismatch repair_Homo sapiens_hsa034300.46911014
72Parkinsons disease_Homo sapiens_hsa050120.46559539
73Renin-angiotensin system_Homo sapiens_hsa046140.45187516
74Galactose metabolism_Homo sapiens_hsa000520.42723710
75Other glycan degradation_Homo sapiens_hsa005110.42613657
76Pyrimidine metabolism_Homo sapiens_hsa002400.41937191
77Proteasome_Homo sapiens_hsa030500.38776100
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32697428
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31023213
80N-Glycan biosynthesis_Homo sapiens_hsa005100.30361438
81Ribosome_Homo sapiens_hsa030100.29965950
82Prion diseases_Homo sapiens_hsa050200.29386559
83Arachidonic acid metabolism_Homo sapiens_hsa005900.29198906
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28123912
85Sphingolipid metabolism_Homo sapiens_hsa006000.27867489
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27035106
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26841741
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26719378
89Mineral absorption_Homo sapiens_hsa049780.26477554
90Linoleic acid metabolism_Homo sapiens_hsa005910.24840341
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20786949
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20540547
93Fatty acid biosynthesis_Homo sapiens_hsa000610.20299434
94Base excision repair_Homo sapiens_hsa034100.20005924
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19646316
96RNA polymerase_Homo sapiens_hsa030200.19496854
97Protein digestion and absorption_Homo sapiens_hsa049740.16904469
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.16602306
99Protein export_Homo sapiens_hsa030600.16546132
100Homologous recombination_Homo sapiens_hsa034400.13029501
101Insulin resistance_Homo sapiens_hsa049310.12780793
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.12065012
103Alzheimers disease_Homo sapiens_hsa050100.10329230
104Nucleotide excision repair_Homo sapiens_hsa034200.08706755
105Ether lipid metabolism_Homo sapiens_hsa005650.08624783
106Huntingtons disease_Homo sapiens_hsa050160.07619953
107Lysosome_Homo sapiens_hsa041420.05598060

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