ACVR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.95038544
2locomotory exploration behavior (GO:0035641)5.83577459
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79273533
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28776773
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18941325
6vocalization behavior (GO:0071625)5.11185385
7layer formation in cerebral cortex (GO:0021819)5.01119189
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81367938
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.78391879
10glutamate secretion (GO:0014047)4.78281463
11synaptic vesicle exocytosis (GO:0016079)4.69722556
12regulation of glutamate receptor signaling pathway (GO:1900449)4.56530869
13regulation of synaptic vesicle exocytosis (GO:2000300)4.48983498
14exploration behavior (GO:0035640)4.38115285
15sodium ion export (GO:0071436)4.24841253
16regulation of synapse structural plasticity (GO:0051823)4.23780812
17protein localization to synapse (GO:0035418)4.16063892
18dendritic spine morphogenesis (GO:0060997)4.11483343
19neurotransmitter secretion (GO:0007269)4.06559639
20cellular potassium ion homeostasis (GO:0030007)4.02579945
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00820623
22regulation of neuronal synaptic plasticity (GO:0048168)3.98905675
23proline transport (GO:0015824)3.96736957
24regulation of synaptic vesicle transport (GO:1902803)3.96642764
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.92503391
26regulation of NFAT protein import into nucleus (GO:0051532)3.78854074
27activation of protein kinase A activity (GO:0034199)3.75072956
28positive regulation of synapse maturation (GO:0090129)3.70204144
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54754687
30neurotransmitter-gated ion channel clustering (GO:0072578)3.54361306
31cell-cell junction maintenance (GO:0045217)3.52846179
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49823503
33neuron cell-cell adhesion (GO:0007158)3.49191242
34neuromuscular process controlling balance (GO:0050885)3.47026378
35cell communication by electrical coupling (GO:0010644)3.43983932
36long-term memory (GO:0007616)3.43025946
37synaptic transmission, glutamatergic (GO:0035249)3.41796364
38regulation of dendritic spine morphogenesis (GO:0061001)3.40937815
39gamma-aminobutyric acid transport (GO:0015812)3.39085549
40dendrite morphogenesis (GO:0048813)3.35663875
41glutamate receptor signaling pathway (GO:0007215)3.35458945
42neuronal action potential propagation (GO:0019227)3.33529462
43regulation of ARF protein signal transduction (GO:0032012)3.31042625
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31001906
45positive regulation of membrane potential (GO:0045838)3.30631779
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25427725
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.24134922
48synaptic vesicle endocytosis (GO:0048488)3.22812204
49apical protein localization (GO:0045176)3.21407731
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21325126
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20666276
52cerebellar Purkinje cell differentiation (GO:0021702)3.18454563
53neuron-neuron synaptic transmission (GO:0007270)3.15885414
54regulation of synaptic plasticity (GO:0048167)3.15402503
55cell migration in hindbrain (GO:0021535)3.14699604
56neuron recognition (GO:0008038)3.13956821
57cerebellar granule cell differentiation (GO:0021707)3.13083742
58regulation of postsynaptic membrane potential (GO:0060078)3.11482047
59regulation of clathrin-mediated endocytosis (GO:2000369)3.10856305
60neurotransmitter transport (GO:0006836)3.10566876
61axonal fasciculation (GO:0007413)3.10099488
62L-amino acid import (GO:0043092)3.09793564
63vesicle transport along microtubule (GO:0047496)3.09597004
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05231111
65auditory behavior (GO:0031223)3.04907440
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02758489
67cell communication involved in cardiac conduction (GO:0086065)3.02677583
68prepulse inhibition (GO:0060134)3.01447277
69cell junction maintenance (GO:0034331)3.00207410
70response to pheromone (GO:0019236)2.97219501
71dendritic spine organization (GO:0097061)2.96500315
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94679370
73response to auditory stimulus (GO:0010996)2.93844027
74establishment of nucleus localization (GO:0040023)2.93671064
75innervation (GO:0060384)2.90132436
76response to histamine (GO:0034776)2.89600555
77regulation of neurotransmitter levels (GO:0001505)2.89183459
78cerebellar Purkinje cell layer development (GO:0021680)2.86632425
79positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86089585
80regulation of early endosome to late endosome transport (GO:2000641)2.82808651
81mating behavior (GO:0007617)2.82658403
82amino acid import (GO:0043090)2.82123570
83regulation of neurotransmitter secretion (GO:0046928)2.81783987
84regulation of dendritic spine development (GO:0060998)2.81139590
85cellular sodium ion homeostasis (GO:0006883)2.80989880
86glycine transport (GO:0015816)2.80960994
87membrane hyperpolarization (GO:0060081)2.80624691
88potassium ion import (GO:0010107)2.79028689
89clathrin coat assembly (GO:0048268)2.77345698
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76163696
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75981572
92social behavior (GO:0035176)2.75504413
93intraspecies interaction between organisms (GO:0051703)2.75504413
94organelle transport along microtubule (GO:0072384)2.74431017
95positive regulation of neurotransmitter secretion (GO:0001956)2.74340982
96central nervous system projection neuron axonogenesis (GO:0021952)2.74334858
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.74327701
98membrane depolarization during action potential (GO:0086010)2.74210025
99dopamine receptor signaling pathway (GO:0007212)2.74017449
100long-term synaptic potentiation (GO:0060291)2.73626390
101regulation of vesicle fusion (GO:0031338)2.72620413
102positive regulation of neurotransmitter transport (GO:0051590)2.70320863
103neuron remodeling (GO:0016322)2.69434137
104neuronal ion channel clustering (GO:0045161)2.68014623
105membrane depolarization (GO:0051899)2.67569042
106neuromuscular process (GO:0050905)2.66554067
107synapse organization (GO:0050808)2.66097806
108synapse assembly (GO:0007416)2.65578079
109negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65533066
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.64084217
111postsynaptic membrane organization (GO:0001941)2.64071761
112epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62907271
113neuromuscular process controlling posture (GO:0050884)2.62227287
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61534796
115histone H3-K9 demethylation (GO:0033169)2.58962801
116epithelial cell-cell adhesion (GO:0090136)2.58836127
117regulation of water loss via skin (GO:0033561)2.57862403
118paraxial mesoderm development (GO:0048339)2.51598875
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.51321866
120regulation of cholesterol homeostasis (GO:2000188)2.48680458
121desmosome organization (GO:0002934)2.47651942
122asymmetric protein localization (GO:0008105)2.47385014
123camera-type eye morphogenesis (GO:0048593)2.38368283
124establishment of skin barrier (GO:0061436)2.37850437
125multicellular organismal water homeostasis (GO:0050891)2.37761714
126embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33415082
127phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.30767959
128semaphorin-plexin signaling pathway (GO:0071526)2.28392707
129developmental cell growth (GO:0048588)2.26206211
130peptidyl-tyrosine autophosphorylation (GO:0038083)2.23644411
131positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23451035
132protein localization to endosome (GO:0036010)2.16600493
133neuron projection extension (GO:1990138)2.16255517
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.13563122
135negative regulation of dendrite morphogenesis (GO:0050774)2.12675169
136signal complex assembly (GO:0007172)2.12011139
137establishment or maintenance of bipolar cell polarity (GO:0061245)2.11730265
138establishment or maintenance of apical/basal cell polarity (GO:0035088)2.11730265
139protein retention in ER lumen (GO:0006621)2.09401356
140cellular component maintenance (GO:0043954)2.09355161
141negative regulation of erythrocyte differentiation (GO:0045647)2.08760891
142regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.07018897
143cellular response to monoamine stimulus (GO:0071868)2.06951413
144cellular response to catecholamine stimulus (GO:0071870)2.06951413
145cellular response to prostaglandin stimulus (GO:0071379)2.03302280
146axon extension (GO:0048675)2.02617950
147adherens junction assembly (GO:0034333)2.02323795
148negative regulation of fatty acid transport (GO:2000192)2.02099620
149respiratory system process (GO:0003016)2.01853574
150water homeostasis (GO:0030104)2.00766033
151activation of MAPKKK activity (GO:0000185)2.00607445
152response to mercury ion (GO:0046689)2.00288385
153receptor recycling (GO:0001881)1.99692661
154skeletal muscle organ development (GO:0060538)1.98812726
155vitamin transmembrane transport (GO:0035461)1.98566711
156response to laminar fluid shear stress (GO:0034616)1.98094742
157maintenance of protein localization in endoplasmic reticulum (GO:0035437)1.97935453
158sodium ion homeostasis (GO:0055078)1.97899866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76820743
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.66024132
3DROSHA_22980978_ChIP-Seq_HELA_Human2.61130411
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60941629
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58778682
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52052017
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51921196
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43569868
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43569868
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.42765206
11REST_21632747_ChIP-Seq_MESCs_Mouse2.31500364
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29127281
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27124192
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27040223
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20254782
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15701213
17GBX2_23144817_ChIP-Seq_PC3_Human2.11040556
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09127326
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06924211
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.05385247
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05093104
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.03173117
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.01827622
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97717620
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90787047
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83474676
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79055434
28AR_21572438_ChIP-Seq_LNCaP_Human1.77880506
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77536376
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.73141285
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.72295791
32* KDM2B_26808549_Chip-Seq_K562_Human1.71848900
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69005104
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.68246478
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60801072
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59171871
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58440218
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.48362335
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48155290
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47417005
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45011730
42CLOCK_20551151_ChIP-Seq_293T_Human1.44892045
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44561503
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43669361
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43669361
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43669361
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43327234
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43314645
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40148989
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39836557
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.37529241
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33334700
53* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33265714
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29789115
55TCF7_22412390_ChIP-Seq_EML_Mouse1.29553492
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27802423
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27617636
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24468786
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.24045043
60AR_19668381_ChIP-Seq_PC3_Human1.23277774
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.22746738
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21888642
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21140003
64ZNF274_21170338_ChIP-Seq_K562_Hela1.21090460
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.20055538
66* CDX2_20551321_ChIP-Seq_CACO-2_Human1.19736612
67AHR_22903824_ChIP-Seq_MCF-7_Human1.18589778
68KDM2B_26808549_Chip-Seq_DND41_Human1.17128065
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16852178
70* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16607905
71* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16335540
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.15295762
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14505099
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.13335522
75LXR_22292898_ChIP-Seq_THP-1_Human1.13311761
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12713841
77SMAD4_21799915_ChIP-Seq_A2780_Human1.11610918
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11083179
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10963192
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10633645
81* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10402971
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.09862587
83* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09363515
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09092396
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08805144
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08282904
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07813357
88* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07491836
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07323376
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.06531554
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05962478
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05399597
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05291839
94ZNF263_19887448_ChIP-Seq_K562_Human1.04184371
95* CTCF_27219007_Chip-Seq_Bcells_Human1.04066039
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.03024485
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02454749
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.01731629
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01237738
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.01152487
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.00357233
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00200550
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00003706
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99851679
105RXR_22108803_ChIP-Seq_LS180_Human0.99545283
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99443526
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.98924079
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.98258435
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98062748
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.97869139
111TP53_16413492_ChIP-PET_HCT116_Human0.97729894
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97370928
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.96804085
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.94224543
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94089953
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93722162
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93112992
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93058417
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.93010041
120AR_25329375_ChIP-Seq_VCAP_Human0.92989817
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92753818
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.92349896
123CREB1_26743006_Chip-Seq_LNCaP_Human0.92133965
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.91783145
125KLF5_25053715_ChIP-Seq_YYC3_Human0.91255769
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90977959
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.90612934
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90532066
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89902041
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89023029
131STAT3_23295773_ChIP-Seq_U87_Human0.87832942
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85910745
133SMC4_20622854_ChIP-Seq_HELA_Human0.85604643
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.84973508
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84930361
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84303524
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83878065
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81630574
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80894858
140* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80595399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.15816210
2MP0003635_abnormal_synaptic_transmissio4.10360143
3MP0004270_analgesia3.77350225
4MP0003880_abnormal_central_pattern3.67972564
5MP0000566_synostosis3.45660641
6MP0005409_darkened_coat_color3.30731972
7MP0002063_abnormal_learning/memory/cond3.27183063
8MP0009745_abnormal_behavioral_response3.00222927
9MP0002822_catalepsy2.99036281
10MP0010234_abnormal_vibrissa_follicle2.88353283
11MP0002064_seizures2.76804256
12MP0009046_muscle_twitch2.66006641
13MP0004858_abnormal_nervous_system2.58773172
14MP0005423_abnormal_somatic_nervous2.58582026
15MP0002572_abnormal_emotion/affect_behav2.49710397
16MP0002139_abnormal_hepatobiliary_system2.30019322
17MP0002734_abnormal_mechanical_nocicepti2.26740048
18MP0009780_abnormal_chondrocyte_physiolo2.26135793
19MP0001968_abnormal_touch/_nociception2.24550786
20MP0001486_abnormal_startle_reflex2.18379247
21MP0001501_abnormal_sleep_pattern2.15526414
22MP0002909_abnormal_adrenal_gland2.08081637
23MP0008004_abnormal_stomach_pH2.00209251
24MP0003329_amyloid_beta_deposits1.99483698
25MP0003453_abnormal_keratinocyte_physiol1.99355851
26MP0002272_abnormal_nervous_system1.94247068
27MP0004811_abnormal_neuron_physiology1.92590052
28MP0003183_abnormal_peptide_metabolism1.91952446
29MP0001440_abnormal_grooming_behavior1.86860731
30MP0002249_abnormal_larynx_morphology1.86706205
31MP0000778_abnormal_nervous_system1.85662292
32MP0009379_abnormal_foot_pigmentation1.84906942
33MP0008569_lethality_at_weaning1.84273773
34MP0002733_abnormal_thermal_nociception1.82766699
35MP0004885_abnormal_endolymph1.76019991
36MP0009840_abnormal_foam_cell1.75468382
37MP0010352_gastrointestinal_tract_polyps1.74761266
38MP0008961_abnormal_basal_metabolism1.74119777
39MP0000569_abnormal_digit_pigmentation1.70145600
40MP0002184_abnormal_innervation1.64462148
41MP0000678_abnormal_parathyroid_gland1.63015177
42MP0001970_abnormal_pain_threshold1.61373741
43MP0002557_abnormal_social/conspecific_i1.61095830
44MP0004924_abnormal_behavior1.55314249
45MP0005386_behavior/neurological_phenoty1.55314249
46MP0003283_abnormal_digestive_organ1.54013212
47MP0000751_myopathy1.53259922
48MP0005666_abnormal_adipose_tissue1.52684476
49MP0000955_abnormal_spinal_cord1.52128973
50MP0005058_abnormal_lysosome_morphology1.51484597
51MP0002735_abnormal_chemical_nociception1.50315474
52MP0003890_abnormal_embryonic-extraembry1.48961163
53MP0002067_abnormal_sensory_capabilities1.48485167
54MP0002736_abnormal_nociception_after1.46276886
55MP0005451_abnormal_body_composition1.46131161
56* MP0005076_abnormal_cell_differentiation1.42499705
57MP0003879_abnormal_hair_cell1.41839326
58MP0003300_gastrointestinal_ulcer1.41518492
59MP0005365_abnormal_bile_salt1.39577216
60MP0002098_abnormal_vibrissa_morphology1.39043321
61MP0005167_abnormal_blood-brain_barrier1.37375653
62MP0004264_abnormal_extraembryonic_tissu1.36563472
63MP0003633_abnormal_nervous_system1.35062861
64MP0002882_abnormal_neuron_morphology1.32448538
65MP0010030_abnormal_orbit_morphology1.31170438
66MP0001188_hyperpigmentation1.30631682
67MP0002066_abnormal_motor_capabilities/c1.26369721
68MP0005248_abnormal_Harderian_gland1.25848887
69MP0003075_altered_response_to1.24806325
70MP0004130_abnormal_muscle_cell1.23326466
71MP0001666_abnormal_nutrient_absorption1.20239066
72MP0003787_abnormal_imprinting1.16807043
73MP0004233_abnormal_muscle_weight1.16646088
74MP0002896_abnormal_bone_mineralization1.15731692
75MP0003091_abnormal_cell_migration1.12914628
76MP0003868_abnormal_feces_composition1.12249173
77MP0004145_abnormal_muscle_electrophysio1.12004632
78MP0005501_abnormal_skin_physiology1.12000592
79MP0001346_abnormal_lacrimal_gland1.11467951
80MP0003123_paternal_imprinting1.10085406
81* MP0002152_abnormal_brain_morphology1.09423683
82MP0002653_abnormal_ependyma_morphology1.09410887
83MP0003122_maternal_imprinting1.09081111
84MP0001984_abnormal_olfaction1.08253018
85MP0001502_abnormal_circadian_rhythm1.07983421
86MP0003631_nervous_system_phenotype1.07036173
87MP0003705_abnormal_hypodermis_morpholog1.05850007
88MP0000462_abnormal_digestive_system1.04446523
89MP0005187_abnormal_penis_morphology1.03977424
90MP0000604_amyloidosis1.03614127
91MP0005360_urolithiasis1.03328521
92MP0003303_peritoneal_inflammation1.02082551
93MP0001177_atelectasis1.00488066
94MP0004043_abnormal_pH_regulation0.99071108
95MP0005085_abnormal_gallbladder_physiolo0.98869399
96MP0002069_abnormal_eating/drinking_beha0.93461750
97MP0004510_myositis0.92839028
98MP0008874_decreased_physiological_sensi0.92473269
99MP0005645_abnormal_hypothalamus_physiol0.90443581
100MP0006276_abnormal_autonomic_nervous0.88898791
101MP0003941_abnormal_skin_development0.88102512
102MP0005646_abnormal_pituitary_gland0.87421967
103MP0004019_abnormal_vitamin_homeostasis0.86227291
104MP0000920_abnormal_myelination0.85136799
105MP0005499_abnormal_olfactory_system0.82594187
106MP0005394_taste/olfaction_phenotype0.82594187
107MP0009672_abnormal_birth_weight0.81319022
108MP0008872_abnormal_physiological_respon0.80866905
109MP0003191_abnormal_cellular_cholesterol0.80302344
110MP0002796_impaired_skin_barrier0.79294915
111MP0005375_adipose_tissue_phenotype0.79084135
112MP0000537_abnormal_urethra_morphology0.78845977
113MP0004085_abnormal_heartbeat0.78524111
114MP0003566_abnormal_cell_adhesion0.78039460
115MP0004947_skin_inflammation0.77683167
116MP0002234_abnormal_pharynx_morphology0.77367131
117MP0003632_abnormal_nervous_system0.74973291
118MP0005257_abnormal_intraocular_pressure0.74836993
119MP0003634_abnormal_glial_cell0.74020289
120MP0003690_abnormal_glial_cell0.73568468
121MP0003938_abnormal_ear_development0.73254131
122MP0002229_neurodegeneration0.73131350
123MP0003172_abnormal_lysosome_physiology0.72708775
124MP0005535_abnormal_body_temperature0.71800823
125MP0003045_fibrosis0.71118951
126MP0002090_abnormal_vision0.70606164
127MP0004484_altered_response_of0.70456449
128MP0004782_abnormal_surfactant_physiolog0.69970952
129MP0009278_abnormal_bone_marrow0.68799311
130MP0000383_abnormal_hair_follicle0.68428866
131MP0001849_ear_inflammation0.68031490
132MP0000013_abnormal_adipose_tissue0.67577805
133MP0005623_abnormal_meninges_morphology0.65681577
134MP0000747_muscle_weakness0.64631393
135MP0002089_abnormal_postnatal_growth/wei0.64075393
136MP0005166_decreased_susceptibility_to0.63513180
137* MP0003861_abnormal_nervous_system0.63419428
138MP0001664_abnormal_digestion0.62887991
139MP0004215_abnormal_myocardial_fiber0.61612033
140MP0003646_muscle_fatigue0.61441657
141MP0000534_abnormal_ureter_morphology0.61334928
142MP0000579_abnormal_nail_morphology0.59725543
143MP0004185_abnormal_adipocyte_glucose0.58409592
144MP0005551_abnormal_eye_electrophysiolog0.57615207
145MP0001943_abnormal_respiration0.57270840
146MP0010769_abnormal_survival0.56504548
147MP0005620_abnormal_muscle_contractility0.55840464
148MP0010678_abnormal_skin_adnexa0.54999883

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.68245057
2Focal motor seizures (HP:0011153)5.36413346
3Visual hallucinations (HP:0002367)4.62679188
4Focal seizures (HP:0007359)4.59381153
5Supranuclear gaze palsy (HP:0000605)3.57279428
6Action tremor (HP:0002345)3.55476332
7Papilledema (HP:0001085)3.45140630
8Epileptic encephalopathy (HP:0200134)3.43746729
9Ankle clonus (HP:0011448)3.24807871
10Absence seizures (HP:0002121)3.18360668
11Poor eye contact (HP:0000817)3.10826287
12Abnormality of the lower motor neuron (HP:0002366)3.09621917
13Progressive cerebellar ataxia (HP:0002073)3.09602427
14Mutism (HP:0002300)3.06979783
15Impaired vibration sensation in the lower limbs (HP:0002166)3.06169452
16Impaired social interactions (HP:0000735)3.04726646
17Abnormal social behavior (HP:0012433)3.04726646
18Urinary bladder sphincter dysfunction (HP:0002839)3.02480670
19Generalized tonic-clonic seizures (HP:0002069)2.97801340
20Atonic seizures (HP:0010819)2.97190535
21Febrile seizures (HP:0002373)2.90908981
22Depression (HP:0000716)2.88000790
23Broad-based gait (HP:0002136)2.79586221
24Dysmetric saccades (HP:0000641)2.75921877
25Dialeptic seizures (HP:0011146)2.75457803
26Postural instability (HP:0002172)2.75127438
27Flat acetabular roof (HP:0003180)2.74245098
28Urinary urgency (HP:0000012)2.73677055
29Hyperparathyroidism (HP:0000843)2.73321086
30Ventricular fibrillation (HP:0001663)2.72584683
31Thin bony cortex (HP:0002753)2.70680487
32Genetic anticipation (HP:0003743)2.70522221
33Hyperactive renin-angiotensin system (HP:0000841)2.70129351
34Dysdiadochokinesis (HP:0002075)2.62638379
35Cerebral inclusion bodies (HP:0100314)2.60480935
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54852550
37Pointed chin (HP:0000307)2.54816322
38Abnormal eating behavior (HP:0100738)2.53694091
39Ankyloglossia (HP:0010296)2.49718501
40Torticollis (HP:0000473)2.47419609
41Insomnia (HP:0100785)2.45896008
42Amblyopia (HP:0000646)2.45766513
43Drooling (HP:0002307)2.44197861
44Excessive salivation (HP:0003781)2.44197861
45Hemiplegia (HP:0002301)2.41242141
46Stereotypic behavior (HP:0000733)2.41137936
47Truncal ataxia (HP:0002078)2.38752978
48Malnutrition (HP:0004395)2.38385084
49Hypercortisolism (HP:0001578)2.38114342
50Megalencephaly (HP:0001355)2.37671842
51Intention tremor (HP:0002080)2.37300384
52Obstructive sleep apnea (HP:0002870)2.36317957
53Exercise-induced myalgia (HP:0003738)2.35279828
54Hyperacusis (HP:0010780)2.33544106
55Impaired smooth pursuit (HP:0007772)2.33412744
56Dysmetria (HP:0001310)2.32436926
57Gaze-evoked nystagmus (HP:0000640)2.31466293
58Neurofibrillary tangles (HP:0002185)2.29498065
59Right ventricular cardiomyopathy (HP:0011663)2.28646416
60Amyotrophic lateral sclerosis (HP:0007354)2.28629441
61Termporal pattern (HP:0011008)2.27767427
62Insidious onset (HP:0003587)2.27767427
63Bundle branch block (HP:0011710)2.26292803
64Anxiety (HP:0000739)2.25899747
65Annular pancreas (HP:0001734)2.25840827
66Osteomalacia (HP:0002749)2.25808075
67Apathy (HP:0000741)2.24827424
68Bronchomalacia (HP:0002780)2.23781000
69Inappropriate behavior (HP:0000719)2.23075250
70Focal dystonia (HP:0004373)2.18191856
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.17532116
72Hemiparesis (HP:0001269)2.17297677
73Diplopia (HP:0000651)2.14232609
74Abnormality of binocular vision (HP:0011514)2.14232609
75Shallow orbits (HP:0000586)2.13380224
76Aplasia involving bones of the extremities (HP:0009825)2.10708044
77Aplasia involving bones of the upper limbs (HP:0009823)2.10708044
78Aplasia of the phalanges of the hand (HP:0009802)2.10708044
79Spastic gait (HP:0002064)2.10072598
80Abnormality of the corticospinal tract (HP:0002492)2.07960067
81Deep venous thrombosis (HP:0002625)2.05071761
82Lower limb amyotrophy (HP:0007210)2.04610921
83Rapidly progressive (HP:0003678)2.03444342
84Vertebral arch anomaly (HP:0008438)2.03437246
85Macroorchidism (HP:0000053)2.02751714
86Abnormality of ocular smooth pursuit (HP:0000617)2.02377605
87Abnormality of the salivary glands (HP:0010286)2.01446206
88Elfin facies (HP:0004428)2.01015595
89Bradykinesia (HP:0002067)2.00706772
90Lower limb muscle weakness (HP:0007340)1.99708802
91Adrenal overactivity (HP:0002717)1.99669236
92Diminished motivation (HP:0000745)1.98168518
93Turricephaly (HP:0000262)1.96236946
94Craniofacial dystonia (HP:0012179)1.95442144
95Status epilepticus (HP:0002133)1.94685110
96Neonatal short-limb short stature (HP:0008921)1.94107348
97Neuronal loss in central nervous system (HP:0002529)1.94043219
98Agitation (HP:0000713)1.93975778
99Intellectual disability, profound (HP:0002187)1.93681735
100Impaired vibratory sensation (HP:0002495)1.90985715
101Loss of speech (HP:0002371)1.89428615
102Neoplasm of the heart (HP:0100544)1.86992753
103Abnormality of oral frenula (HP:0000190)1.86212449
104Resting tremor (HP:0002322)1.86173521
105Difficulty running (HP:0009046)1.84986131
106Systemic lupus erythematosus (HP:0002725)1.84842604
107Polyphagia (HP:0002591)1.84433869
108Lower limb asymmetry (HP:0100559)1.83533448
109Partial duplication of thumb phalanx (HP:0009944)1.83435228
110Sudden death (HP:0001699)1.83375272
111Achilles tendon contracture (HP:0001771)1.82930223
112Epileptiform EEG discharges (HP:0011182)1.82688407
113Disinhibition (HP:0000734)1.82606727
114Scanning speech (HP:0002168)1.79312078
115EEG with generalized epileptiform discharges (HP:0011198)1.79225631
116Spinal cord compression (HP:0002176)1.79062864
117Hyperventilation (HP:0002883)1.78300673
118Arnold-Chiari malformation (HP:0002308)1.78116189
119Hammertoe (HP:0001765)1.76500224
120Broad metatarsal (HP:0001783)1.76160268
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75439235
122Hypsarrhythmia (HP:0002521)1.74975674
123Upper limb amyotrophy (HP:0009129)1.72292758
124Distal upper limb amyotrophy (HP:0007149)1.72292758
125Abnormal EKG (HP:0003115)1.71597762
126Syncope (HP:0001279)1.71534662
127Thickened helices (HP:0000391)1.71154981
128Clonus (HP:0002169)1.70786946
129Complement deficiency (HP:0004431)1.70781872
130Astrocytoma (HP:0009592)1.70715354
131Abnormality of the astrocytes (HP:0100707)1.70715354
132Visceral angiomatosis (HP:0100761)1.70188464
133Increased circulating renin level (HP:0000848)1.68192287
134Bowel incontinence (HP:0002607)1.67748653
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.67405201
136Germ cell neoplasia (HP:0100728)1.67217925
137Amyloidosis (HP:0011034)1.66869195
138Glomerulonephritis (HP:0000099)1.66762110
139Abnormality of permanent molar morphology (HP:0011071)1.65793717
140Abnormality of the dental root (HP:0006486)1.65793717
141Taurodontia (HP:0000679)1.65793717
142Hypercalciuria (HP:0002150)1.61955407
143Hypophosphatemia (HP:0002148)1.61447453
144Hyperaldosteronism (HP:0000859)1.61224130
145Abnormality of the aortic arch (HP:0012303)1.61004988
146Nuclear cataract (HP:0100018)1.60748051
147Axonal loss (HP:0003447)1.59596386
148Peripheral hypomyelination (HP:0007182)1.58447792
149Arterial tortuosity (HP:0005116)1.58004697
150Onion bulb formation (HP:0003383)1.57845129
151Segmental peripheral demyelination/remyelination (HP:0003481)1.55971674
152Bone pain (HP:0002653)1.54674038
153Abnormality of molar (HP:0011077)1.54022575
154Abnormality of molar morphology (HP:0011070)1.54022575
155Rickets (HP:0002748)1.53935007
156Abnormal large intestine physiology (HP:0012700)1.53423157
157Esophageal varix (HP:0002040)1.52422950
158Papillary thyroid carcinoma (HP:0002895)1.52338353
159Cerebral aneurysm (HP:0004944)1.52252128
160Sleep apnea (HP:0010535)1.52204897
161Vascular tortuosity (HP:0004948)1.52061566
162Hemorrhage of the eye (HP:0011885)1.52050238
163Neonatal death (HP:0003811)1.50863988
164Hemangiomatosis (HP:0007461)1.48976472
165Widely patent fontanelles and sutures (HP:0004492)1.48578096
166Dementia (HP:0000726)1.48492030
167Delayed epiphyseal ossification (HP:0002663)1.48309210
168Partial duplication of the phalanx of hand (HP:0009999)1.46633639
169Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.46459853
170Renovascular hypertension (HP:0100817)1.45876218
171Abnormality of complement system (HP:0005339)1.45164679
172Abnormality of chloride homeostasis (HP:0011422)1.44325129
173Hypercalcemia (HP:0003072)1.43514002
174Broad face (HP:0000283)1.43397768
175Ulnar bowing (HP:0003031)1.43333381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.48024882
2EPHA43.69095282
3MARK13.66044580
4NTRK33.45377211
5DAPK22.58087515
6KSR22.46543301
7MAP3K42.42246678
8MINK12.35567358
9CDK122.31448827
10PAK62.26249815
11PRKD32.23404018
12NTRK22.04427330
13CAMKK11.96789914
14TAOK11.79023704
15LATS11.74991846
16MAP2K41.69790829
17KSR11.66947139
18RIPK11.61100275
19MAP3K21.60864066
20SIK21.59890930
21TYRO31.59182623
22STK381.58293469
23NTRK11.56457932
24PHKG11.53270216
25PHKG21.53270216
26TRIB31.45591830
27DAPK11.42359059
28MAP2K71.41863070
29CDK51.41436968
30CASK1.41031941
31EPHA21.40436083
32LATS21.40199114
33IRAK31.40135175
34RIPK41.35355614
35SIK11.31835066
36ERN11.30365991
37ALK1.27037491
38LMTK21.25175443
39RET1.21302912
40NEK11.18466203
41NEK61.13209335
42FGFR41.12803505
43PKN21.08515096
44STK111.02645264
45PRKCH0.98072636
46EPHB10.96353659
47SMG10.93656104
48MAP3K130.92389598
49CAMK1G0.91726536
50MAP3K70.90569729
51MAP3K120.90240043
52WNK30.87431879
53MOS0.86719050
54STK240.86663285
55DYRK1B0.85861085
56MTOR0.85851684
57MAPK130.85459757
58ICK0.84561225
59MARK20.83491352
60MAPK150.83433679
61SGK30.82880354
62PTK20.82118902
63FES0.81867819
64UHMK10.80508391
65DMPK0.80460597
66PLK20.78002313
67TAOK20.77413290
68PRKCG0.76522450
69PDK10.75874137
70MET0.75572982
71FER0.75276799
72CAMK10.74241736
73MAP3K10.73908895
74GRK50.72761621
75IRAK20.71458703
76PDGFRA0.71455153
77PAK30.70880530
78BRAF0.70581257
79CAMKK20.70097257
80SGK10.70061438
81EEF2K0.69831354
82CDK150.69674319
83PDPK10.68485526
84EPHB20.68282227
85CDK180.68090022
86SCYL20.65980377
87CSNK1G20.65614136
88CDK140.63726762
89CAMK2A0.62485132
90PRPF4B0.61859549
91WNK10.61047906
92MAP3K60.60969985
93ACVR1B0.60897104
94CDK190.60766465
95PNCK0.59264633
96SGK4940.57935085
97SGK2230.57935085
98FGFR20.57316217
99RPS6KA20.56986577
100CDK11A0.56965628
101PRKCZ0.56566044
102RAF10.56406051
103STK38L0.55663300
104MST1R0.55637740
105FYN0.54424399
106MATK0.54255969
107SGK20.53713382
108MAP3K110.53703762
109EPHA30.53386709
110ERBB30.53000632
111FGFR30.52304758
112RPS6KA30.51961871
113MAP3K30.50684455
114DDR20.50376456
115FGR0.49421059
116CDC42BPA0.48034377
117ARAF0.47331797
118CAMK40.46433610
119PTK60.46401330
120BMX0.44488516
121DYRK1A0.44218792
122MELK0.43743778
123MAPK120.43320456
124MAP2K10.41971980
125MAP2K20.41950990
126PTK2B0.39900535
127MAPK100.38434662
128ERBB20.36709185
129CAMK1D0.34391193
130CAMK2B0.33666847
131FGFR10.33425388
132PDGFRB0.32820359
133MAP3K100.32656162

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65645615
2Nicotine addiction_Homo sapiens_hsa050332.59389804
3Synaptic vesicle cycle_Homo sapiens_hsa047212.56350219
4Olfactory transduction_Homo sapiens_hsa047402.37798657
5Long-term potentiation_Homo sapiens_hsa047202.32436864
6Circadian entrainment_Homo sapiens_hsa047132.26534293
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18472867
8GABAergic synapse_Homo sapiens_hsa047272.11122717
9Glutamatergic synapse_Homo sapiens_hsa047242.05204137
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00714929
11Salivary secretion_Homo sapiens_hsa049701.93032636
12Amphetamine addiction_Homo sapiens_hsa050311.92467914
13Morphine addiction_Homo sapiens_hsa050321.91445302
14Gastric acid secretion_Homo sapiens_hsa049711.87724683
15Dopaminergic synapse_Homo sapiens_hsa047281.83389526
16Cholinergic synapse_Homo sapiens_hsa047251.74988232
17Insulin secretion_Homo sapiens_hsa049111.73998700
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69180579
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68015723
20Prion diseases_Homo sapiens_hsa050201.62931514
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62092234
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60968261
23Renin secretion_Homo sapiens_hsa049241.59455747
24GnRH signaling pathway_Homo sapiens_hsa049121.48722086
25Nitrogen metabolism_Homo sapiens_hsa009101.45370668
26Type II diabetes mellitus_Homo sapiens_hsa049301.43603944
27Cocaine addiction_Homo sapiens_hsa050301.38365926
28Long-term depression_Homo sapiens_hsa047301.37615244
29Gap junction_Homo sapiens_hsa045401.33603519
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33186943
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32319610
32Glioma_Homo sapiens_hsa052141.31291220
33Estrogen signaling pathway_Homo sapiens_hsa049151.30131254
34Calcium signaling pathway_Homo sapiens_hsa040201.29009976
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.28551660
36Notch signaling pathway_Homo sapiens_hsa043301.28332339
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23087359
38Axon guidance_Homo sapiens_hsa043601.17556782
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15883621
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15500886
41Histidine metabolism_Homo sapiens_hsa003401.15106691
42Taste transduction_Homo sapiens_hsa047421.15004971
43cAMP signaling pathway_Homo sapiens_hsa040241.13479330
44Serotonergic synapse_Homo sapiens_hsa047261.13220095
45Dorso-ventral axis formation_Homo sapiens_hsa043201.11477859
46ErbB signaling pathway_Homo sapiens_hsa040121.11335516
47Amoebiasis_Homo sapiens_hsa051461.08363751
48Adherens junction_Homo sapiens_hsa045201.07464564
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06972598
50Melanogenesis_Homo sapiens_hsa049161.05051452
51mTOR signaling pathway_Homo sapiens_hsa041501.05030964
52Phenylalanine metabolism_Homo sapiens_hsa003601.04375000
53VEGF signaling pathway_Homo sapiens_hsa043700.98310322
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97039778
55Endometrial cancer_Homo sapiens_hsa052130.95785473
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.95539155
57Dilated cardiomyopathy_Homo sapiens_hsa054140.91050337
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.89769613
59Sphingolipid metabolism_Homo sapiens_hsa006000.89624361
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88859546
61Pancreatic secretion_Homo sapiens_hsa049720.88485786
62Thyroid cancer_Homo sapiens_hsa052160.84036568
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83812500
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83770459
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.83290281
66Choline metabolism in cancer_Homo sapiens_hsa052310.82558266
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81133258
68Acute myeloid leukemia_Homo sapiens_hsa052210.80746758
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79987327
70PPAR signaling pathway_Homo sapiens_hsa033200.79186151
71Ovarian steroidogenesis_Homo sapiens_hsa049130.78905735
72Non-small cell lung cancer_Homo sapiens_hsa052230.78429487
73Bile secretion_Homo sapiens_hsa049760.77919843
74Mineral absorption_Homo sapiens_hsa049780.77714568
75Oocyte meiosis_Homo sapiens_hsa041140.77548628
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77500948
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.77046904
78Thyroid hormone synthesis_Homo sapiens_hsa049180.76446622
79Bladder cancer_Homo sapiens_hsa052190.75665558
80MAPK signaling pathway_Homo sapiens_hsa040100.75330456
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.72866283
82Protein digestion and absorption_Homo sapiens_hsa049740.71904901
83Pancreatic cancer_Homo sapiens_hsa052120.71852121
84Glucagon signaling pathway_Homo sapiens_hsa049220.71576533
85Insulin signaling pathway_Homo sapiens_hsa049100.71430602
86Arginine biosynthesis_Homo sapiens_hsa002200.69901635
87Rap1 signaling pathway_Homo sapiens_hsa040150.69506818
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69328467
89Renal cell carcinoma_Homo sapiens_hsa052110.69234451
90Hepatitis C_Homo sapiens_hsa051600.67964588
91Other glycan degradation_Homo sapiens_hsa005110.67344919
92Vitamin digestion and absorption_Homo sapiens_hsa049770.66631076
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66130857
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65513863
95Complement and coagulation cascades_Homo sapiens_hsa046100.64919304
96Colorectal cancer_Homo sapiens_hsa052100.61430796
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.60145384
98Endocytosis_Homo sapiens_hsa041440.59914770
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.59092280
100Collecting duct acid secretion_Homo sapiens_hsa049660.58928814
101Phototransduction_Homo sapiens_hsa047440.58490711
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58019536
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57996317
104TNF signaling pathway_Homo sapiens_hsa046680.56829984
105Ras signaling pathway_Homo sapiens_hsa040140.56387958
106FoxO signaling pathway_Homo sapiens_hsa040680.54085732
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53696960
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52194470
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51719839
110Osteoclast differentiation_Homo sapiens_hsa043800.51463202
111Cardiac muscle contraction_Homo sapiens_hsa042600.51154470
112Inositol phosphate metabolism_Homo sapiens_hsa005620.50351003
113Tight junction_Homo sapiens_hsa045300.49960415
114Platelet activation_Homo sapiens_hsa046110.48966498
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48966225
116Insulin resistance_Homo sapiens_hsa049310.48647066
117Wnt signaling pathway_Homo sapiens_hsa043100.48100662
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47109385
119Prolactin signaling pathway_Homo sapiens_hsa049170.46245634
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43571428
121AMPK signaling pathway_Homo sapiens_hsa041520.43402459
122Chronic myeloid leukemia_Homo sapiens_hsa052200.43211930
123Chemokine signaling pathway_Homo sapiens_hsa040620.42705954
124Proteoglycans in cancer_Homo sapiens_hsa052050.42448634
125Fatty acid biosynthesis_Homo sapiens_hsa000610.41171105
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40774160
127Vibrio cholerae infection_Homo sapiens_hsa051100.40579615
128Circadian rhythm_Homo sapiens_hsa047100.40192591
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40171424

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