ACVR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of integrin-mediated signaling pathway (GO:2001044)4.00777425
2hypotonic response (GO:0006971)3.55173545
3mesodermal cell differentiation (GO:0048333)3.46404966
4plasma membrane repair (GO:0001778)3.30916862
5positive regulation of receptor recycling (GO:0001921)3.23347748
6collagen fibril organization (GO:0030199)3.22882590
7cell-substrate junction assembly (GO:0007044)3.14085683
8negative regulation of protein localization to plasma membrane (GO:1903077)3.12071190
9positive regulation of extracellular matrix organization (GO:1903055)3.09983503
10protein heterotrimerization (GO:0070208)3.08655404
11fibril organization (GO:0097435)3.06986441
12blood vessel maturation (GO:0001955)3.05184003
13regulation of extracellular matrix disassembly (GO:0010715)3.04877868
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.02368985
15axon extension involved in axon guidance (GO:0048846)3.02368985
16regulation of early endosome to late endosome transport (GO:2000641)3.02229816
17adhesion of symbiont to host cell (GO:0044650)3.02068122
18virion attachment to host cell (GO:0019062)3.02068122
19chondrocyte proliferation (GO:0035988)3.01391340
20cell migration involved in heart development (GO:0060973)3.00923599
21cellular response to vitamin D (GO:0071305)2.95582151
22barbed-end actin filament capping (GO:0051016)2.94232562
23platelet degranulation (GO:0002576)2.93512553
24regulation of transforming growth factor beta1 production (GO:0032908)2.92434524
25cellular response to thyroid hormone stimulus (GO:0097067)2.89539159
26smooth muscle tissue development (GO:0048745)2.87294206
27extracellular matrix disassembly (GO:0022617)2.87107834
28positive regulation of osteoblast proliferation (GO:0033690)2.86440820
29hyaluronan catabolic process (GO:0030214)2.86273562
30extracellular matrix assembly (GO:0085029)2.85423324
31mannose metabolic process (GO:0006013)2.84077226
32negative regulation of homotypic cell-cell adhesion (GO:0034111)2.83540894
33cellular response to vitamin (GO:0071295)2.81164167
34positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80681439
35negative regulation of platelet activation (GO:0010544)2.79972871
36phospholipid scrambling (GO:0017121)2.79458611
37multicellular organismal catabolic process (GO:0044243)2.78027022
38endocytic recycling (GO:0032456)2.76490289
39multicellular organismal metabolic process (GO:0044236)2.75082421
40cell adhesion mediated by integrin (GO:0033627)2.72183069
41negative regulation of focal adhesion assembly (GO:0051895)2.71768490
42negative regulation of cell junction assembly (GO:1901889)2.71768490
43negative regulation of adherens junction organization (GO:1903392)2.71768490
44positive regulation of endothelial cell apoptotic process (GO:2000353)2.69591455
45mesenchymal-epithelial cell signaling (GO:0060638)2.67267979
46platelet aggregation (GO:0070527)2.65252200
47skin morphogenesis (GO:0043589)2.63462965
48wound healing, spreading of epidermal cells (GO:0035313)2.63093307
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.62740157
50sequestering of extracellular ligand from receptor (GO:0035581)2.61705277
51positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60138894
52regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59531295
53basement membrane organization (GO:0071711)2.59310774
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57680028
55regulation of transforming growth factor beta2 production (GO:0032909)2.55869209
56platelet-derived growth factor receptor signaling pathway (GO:0048008)2.53763011
57endodermal cell differentiation (GO:0035987)2.53682963
58dendrite morphogenesis (GO:0048813)2.52566327
59negative regulation of chondrocyte differentiation (GO:0032331)2.51040614
60cell-matrix adhesion (GO:0007160)2.50293910
61fibrinolysis (GO:0042730)2.48990806
62protein localization to endosome (GO:0036010)2.48946548
63adhesion of symbiont to host (GO:0044406)2.47782622
64stress fiber assembly (GO:0043149)2.45460514
65positive regulation of hemostasis (GO:1900048)2.45226173
66positive regulation of blood coagulation (GO:0030194)2.45226173
67extracellular matrix organization (GO:0030198)2.44089318
68negative regulation of neurotransmitter secretion (GO:0046929)2.43846429
69extracellular structure organization (GO:0043062)2.43365638
70glial cell migration (GO:0008347)2.43087205
71chondroitin sulfate biosynthetic process (GO:0030206)2.42867865
72axonal fasciculation (GO:0007413)2.41103775
73chondrocyte development (GO:0002063)2.40938167
74wound healing (GO:0042060)2.40743950
75negative regulation of smooth muscle cell migration (GO:0014912)2.40166552
76vocalization behavior (GO:0071625)2.39592581
77negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39029499
78positive regulation of coagulation (GO:0050820)2.38733148
79axon extension (GO:0048675)2.37644470
80type B pancreatic cell proliferation (GO:0044342)2.36931668
81hippo signaling (GO:0035329)2.36387419
82response to thyroid hormone (GO:0097066)2.36331346
83regulation of collagen metabolic process (GO:0010712)2.36067774
84negative regulation of catenin import into nucleus (GO:0035414)2.34589543
85decidualization (GO:0046697)2.34315515
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34058028
87vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33379365
88endothelial cell morphogenesis (GO:0001886)2.33187141
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32702085
90heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.32664778
91angiogenesis involved in wound healing (GO:0060055)2.32579416
92cell-substrate adhesion (GO:0031589)2.31210999
93layer formation in cerebral cortex (GO:0021819)2.30728374
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30629565
95cell migration involved in sprouting angiogenesis (GO:0002042)2.30531717
96regulation of dendritic spine morphogenesis (GO:0061001)2.30027561
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29098651
98bone trabecula formation (GO:0060346)2.25600491
99positive regulation of axon extension (GO:0045773)2.21101176
100protein targeting to plasma membrane (GO:0072661)2.20680980
101negative regulation of fatty acid transport (GO:2000192)2.20328643
102regulation of axon extension involved in axon guidance (GO:0048841)2.19123108
103apoptotic cell clearance (GO:0043277)2.17535608
104negative regulation of cartilage development (GO:0061037)2.16821315
105regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.16138284
106neuron recognition (GO:0008038)2.14597186
107desmosome organization (GO:0002934)2.13581851
108adherens junction assembly (GO:0034333)2.09470630
109metanephric mesenchyme development (GO:0072075)2.09231402
110dendritic spine morphogenesis (GO:0060997)2.08678535
111protein localization to cell surface (GO:0034394)2.08351805
112camera-type eye morphogenesis (GO:0048593)2.07708010
113vascular endothelial growth factor signaling pathway (GO:0038084)2.06542875
114positive regulation of fibroblast migration (GO:0010763)2.05962172
115semaphorin-plexin signaling pathway (GO:0071526)2.05365255
116regulation of tight junction assembly (GO:2000810)2.04593499
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.04489823
118regulation of glomerular filtration (GO:0003093)2.04344618
119ephrin receptor signaling pathway (GO:0048013)2.03357300
120inner ear receptor cell development (GO:0060119)2.03303327
121lymph vessel development (GO:0001945)2.03159730
122tooth mineralization (GO:0034505)2.03068166
123cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.01941199
124neuron projection extension (GO:1990138)2.01453188
125regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.01252910
126locomotory exploration behavior (GO:0035641)2.01059393
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.01035821
128kidney mesenchyme development (GO:0072074)2.00726911
129establishment of nucleus localization (GO:0040023)1.99434075
130dermatan sulfate biosynthetic process (GO:0030208)1.99371658
131cell communication by electrical coupling (GO:0010644)1.99251996
132positive regulation of p38MAPK cascade (GO:1900745)1.99031314
133regulation of p38MAPK cascade (GO:1900744)1.98289636
134collagen metabolic process (GO:0032963)1.97935945
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.97908546
136regulation of axon guidance (GO:1902667)1.97865887
137cytoskeletal anchoring at plasma membrane (GO:0007016)1.97408984
138dendritic spine organization (GO:0097061)1.96737688
139body morphogenesis (GO:0010171)1.94916567
140extracellular fibril organization (GO:0043206)1.94346670
141hemidesmosome assembly (GO:0031581)1.93987926
142negative chemotaxis (GO:0050919)1.92761732
143collagen catabolic process (GO:0030574)1.92409949
144substrate-dependent cell migration (GO:0006929)1.92364297
145multicellular organismal macromolecule metabolic process (GO:0044259)1.92362325
146regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.91782300
147cell migration in hindbrain (GO:0021535)1.91357862
148keratan sulfate catabolic process (GO:0042340)1.91034052
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.91008953
150epithelial cell-cell adhesion (GO:0090136)1.91008276
151blood vessel endothelial cell migration (GO:0043534)1.90844893
152substrate adhesion-dependent cell spreading (GO:0034446)1.90680904
153positive regulation of glycogen biosynthetic process (GO:0045725)1.90519322
154adherens junction organization (GO:0034332)1.90280612
155regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.89974485
156craniofacial suture morphogenesis (GO:0097094)1.89578145
157heparan sulfate proteoglycan metabolic process (GO:0030201)1.89418062
158peptidyl-proline hydroxylation (GO:0019511)1.89227940
159replacement ossification (GO:0036075)1.88950358
160endochondral ossification (GO:0001958)1.88950358
161cartilage morphogenesis (GO:0060536)1.88853233
162polarized epithelial cell differentiation (GO:0030859)1.88820257
163positive regulation of dendritic spine morphogenesis (GO:0061003)1.88750917
164regulation of dendritic spine development (GO:0060998)1.88388070
165regulation of cartilage development (GO:0061035)1.88123120
166lymphangiogenesis (GO:0001946)1.88106441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.49294663
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.90931394
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67510675
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56318565
5GATA2_21666600_ChIP-Seq_HMVEC_Human2.40146604
6EZH2_22144423_ChIP-Seq_EOC_Human2.33889899
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32519264
8* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.23776634
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23101109
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23101109
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20486866
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.16107965
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13477066
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11325477
15GBX2_23144817_ChIP-Seq_PC3_Human2.08826219
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07048410
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99921891
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99470426
19AR_21572438_ChIP-Seq_LNCaP_Human1.91747941
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91490429
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89400030
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.86972439
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82449785
24* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.79658724
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78334930
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72151312
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.70769586
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69717363
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68565450
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68565450
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.63563931
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59493153
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58446284
34TP53_18474530_ChIP-ChIP_U2OS_Human1.57442421
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55977435
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55361578
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.54471188
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.54397962
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53812896
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53812896
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53455652
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.53098481
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51051720
44* CJUN_26792858_Chip-Seq_BT549_Human1.49334688
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49004174
46CLOCK_20551151_ChIP-Seq_293T_Human1.47946676
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45845373
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44308397
49TP53_16413492_ChIP-PET_HCT116_Human1.44184175
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43496280
51AHR_22903824_ChIP-Seq_MCF-7_Human1.43133736
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41293638
53DROSHA_22980978_ChIP-Seq_HELA_Human1.40430517
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.38144670
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36992405
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.36373952
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.36372841
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34876428
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33701634
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30231190
61TP63_23658742_ChIP-Seq_EP156T_Human1.29114152
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28846067
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.28832949
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.28325756
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28160264
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27979488
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26780087
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26071519
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.24628441
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23634197
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23373046
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.23291507
73* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23140308
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.22207825
75* TBX20_22328084_ChIP-Seq_HEART_Mouse1.22104176
76* TBX20_22080862_ChIP-Seq_HEART_Mouse1.22104176
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.19990468
78KDM2B_26808549_Chip-Seq_K562_Human1.18988357
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.17808911
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.16515223
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14934885
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13522687
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.13209753
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11664335
85SMAD4_21799915_ChIP-Seq_A2780_Human1.11591919
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11195697
87* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10449087
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.10239242
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09699560
90ZNF274_21170338_ChIP-Seq_K562_Hela1.09665802
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08461514
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08264390
93RXR_22108803_ChIP-Seq_LS180_Human1.08227362
94VDR_24787735_ChIP-Seq_THP-1_Human1.07292892
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06789645
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06108727
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05071818
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03608291
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03464580
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03145456
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02255923
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02238352
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02009862
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01807500
105* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01669286
106GATA1_22025678_ChIP-Seq_K562_Human1.01346798
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.01119445
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00953932
109* RXR_22158963_ChIP-Seq_LIVER_Mouse1.00864535
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00719815
111* BCAT_22108803_ChIP-Seq_LS180_Human1.00704660
112* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00135233
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.98522649
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97634777
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97604317
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97573169
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97202628
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96713918
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96561828
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.96427932
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96378835
122BRD4_25478319_ChIP-Seq_HGPS_Human0.95887215
123* GATA1_19941826_ChIP-Seq_K562_Human0.95607713
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94578996
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93586252
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.93447992
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93319025
128LXR_22158963_ChIP-Seq_LIVER_Mouse0.93270164
129* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93178019
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93134569
131* SOX2_20726797_ChIP-Seq_SW620_Human0.93080624
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92972568
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92258085
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91237131
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.90863503
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90438420
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90265079
138P300_19829295_ChIP-Seq_ESCs_Human0.90167817
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90151580
140* GATA2_19941826_ChIP-Seq_K562_Human0.89856914
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.89231333
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89070620
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88967841
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88860923
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88823688
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88784252
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.88413648
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87933026
149* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87469837
150AR_19668381_ChIP-Seq_PC3_Human0.86592218
151AR_25329375_ChIP-Seq_VCAP_Human0.86287608
152TCF4_18268006_ChIP-ChIP_LS174T_Human0.86210106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.99295523
2MP0005275_abnormal_skin_tensile3.76058185
3MP0005503_abnormal_tendon_morphology3.40517410
4MP0006054_spinal_hemorrhage3.12089066
5MP0003705_abnormal_hypodermis_morpholog3.07860883
6MP0004272_abnormal_basement_membrane2.80671737
7MP0004859_abnormal_synaptic_plasticity2.50920924
8MP0005623_abnormal_meninges_morphology2.42967165
9MP0003950_abnormal_plasma_membrane2.39362306
10MP0009780_abnormal_chondrocyte_physiolo2.31030238
11MP0005058_abnormal_lysosome_morphology2.28724286
12MP0003279_aneurysm2.28326670
13MP0005464_abnormal_platelet_physiology2.18322135
14MP0008004_abnormal_stomach_pH2.07117452
15MP0010368_abnormal_lymphatic_system1.96208518
16MP0009384_cardiac_valve_regurgitation1.93510206
17MP0009840_abnormal_foam_cell1.92965663
18MP0004510_myositis1.88205451
19MP0010352_gastrointestinal_tract_polyps1.87437176
20MP0003300_gastrointestinal_ulcer1.83497984
21MP0010030_abnormal_orbit_morphology1.80873638
22MP0005248_abnormal_Harderian_gland1.77125276
23MP0003385_abnormal_body_wall1.74781322
24MP0004858_abnormal_nervous_system1.72281567
25MP0002108_abnormal_muscle_morphology1.69470796
26MP0005508_abnormal_skeleton_morphology1.68246858
27MP0002295_abnormal_pulmonary_circulatio1.66019720
28MP0009053_abnormal_anal_canal1.65494734
29MP0009250_abnormal_appendicular_skeleto1.65360755
30MP0002896_abnormal_bone_mineralization1.63878559
31MP0000751_myopathy1.63159123
32MP0005164_abnormal_response_to1.54780524
33MP0010234_abnormal_vibrissa_follicle1.54376311
34MP0001299_abnormal_eye_distance/1.53257513
35MP0000343_altered_response_to1.53145446
36MP0001958_emphysema1.51313594
37MP0002837_dystrophic_cardiac_calcinosis1.45495443
38MP0003566_abnormal_cell_adhesion1.43515269
39MP0003091_abnormal_cell_migration1.40788401
40MP0005171_absent_coat_pigmentation1.40740781
41MP0004270_analgesia1.38956632
42MP0003453_abnormal_keratinocyte_physiol1.37844068
43MP0002998_abnormal_bone_remodeling1.36634918
44MP0001879_abnormal_lymphatic_vessel1.36589222
45MP0003942_abnormal_urinary_system1.32667089
46MP0000013_abnormal_adipose_tissue1.32398195
47MP0002877_abnormal_melanocyte_morpholog1.32055904
48MP0003635_abnormal_synaptic_transmissio1.30704192
49MP0002060_abnormal_skin_morphology1.30692475
50MP0003283_abnormal_digestive_organ1.28842580
51MP0003191_abnormal_cellular_cholesterol1.24268677
52MP0004084_abnormal_cardiac_muscle1.23661516
53MP0005257_abnormal_intraocular_pressure1.23521205
54MP0001533_abnormal_skeleton_physiology1.21285015
55MP0000537_abnormal_urethra_morphology1.20489889
56MP0001849_ear_inflammation1.19137911
57MP0005409_darkened_coat_color1.18767677
58MP0003448_altered_tumor_morphology1.18502758
59MP0005076_abnormal_cell_differentiation1.17975844
60MP0002282_abnormal_trachea_morphology1.16577384
61MP0003045_fibrosis1.13320747
62MP0004145_abnormal_muscle_electrophysio1.13257423
63MP0005390_skeleton_phenotype1.12306370
64* MP0003755_abnormal_palate_morphology1.11228371
65MP0005367_renal/urinary_system_phenotyp1.09874558
66MP0000516_abnormal_urinary_system1.09874558
67MP0000762_abnormal_tongue_morphology1.09869595
68MP0002909_abnormal_adrenal_gland1.09318803
69MP0005165_increased_susceptibility_to1.08687176
70* MP0000163_abnormal_cartilage_morphology1.06800904
71MP0001243_abnormal_dermal_layer1.06485263
72MP0002063_abnormal_learning/memory/cond1.06298592
73MP0000534_abnormal_ureter_morphology1.05200054
74MP0003172_abnormal_lysosome_physiology1.03777764
75MP0004233_abnormal_muscle_weight1.03146525
76MP0004883_abnormal_blood_vessel1.02766155
77MP0000579_abnormal_nail_morphology1.02639271
78MP0004134_abnormal_chest_morphology1.01590284
79MP0003122_maternal_imprinting1.01025625
80MP0000462_abnormal_digestive_system0.99083176
81MP0003656_abnormal_erythrocyte_physiolo0.98200144
82MP0000733_abnormal_muscle_development0.97545473
83MP0006138_congestive_heart_failure0.96547637
84MP0002115_abnormal_skeleton_extremities0.96310207
85MP0002234_abnormal_pharynx_morphology0.95407127
86MP0000767_abnormal_smooth_muscle0.94725354
87MP0004036_abnormal_muscle_relaxation0.94541105
88MP0005187_abnormal_penis_morphology0.94464804
89MP0002249_abnormal_larynx_morphology0.93046282
90MP0000465_gastrointestinal_hemorrhage0.92490965
91MP0003115_abnormal_respiratory_system0.91250768
92MP0000003_abnormal_adipose_tissue0.90249826
93MP0001915_intracranial_hemorrhage0.89966744
94MP0003795_abnormal_bone_structure0.89649176
95MP0000858_altered_metastatic_potential0.87944140
96MP0001340_abnormal_eyelid_morphology0.87734893
97MP0002254_reproductive_system_inflammat0.87107875
98* MP0001614_abnormal_blood_vessel0.86361911
99MP0005595_abnormal_vascular_smooth0.86057138
100MP0003941_abnormal_skin_development0.85989442
101MP0005167_abnormal_blood-brain_barrier0.85886374
102MP0002168_other_aberrant_phenotype0.85480513
103MP0003828_pulmonary_edema0.85367375
104MP0004087_abnormal_muscle_fiber0.84939621
105MP0001542_abnormal_bone_strength0.84830252
106MP0010386_abnormal_urinary_bladder0.84087823
107MP0002932_abnormal_joint_morphology0.81548283
108MP0000749_muscle_degeneration0.81309004
109MP0000778_abnormal_nervous_system0.80868145
110MP0003075_altered_response_to0.80854115
111MP0005023_abnormal_wound_healing0.78564826
112MP0004484_altered_response_of0.78022618
113MP0005330_cardiomyopathy0.77285005
114MP0005620_abnormal_muscle_contractility0.77165519
115MP0001177_atelectasis0.77127946
116MP0009745_abnormal_behavioral_response0.77113001
117* MP0002116_abnormal_craniofacial_bone0.76255011
118* MP0003935_abnormal_craniofacial_develop0.75808683
119MP0003119_abnormal_digestive_system0.75330420
120MP0002113_abnormal_skeleton_development0.75318497
121MP0004185_abnormal_adipocyte_glucose0.75227817
122MP0004085_abnormal_heartbeat0.75215597
123MP0005369_muscle_phenotype0.75136276
124MP0003252_abnormal_bile_duct0.74931145
125MP0000759_abnormal_skeletal_muscle0.74580590
126MP0003880_abnormal_central_pattern0.74185791
127MP0003303_peritoneal_inflammation0.73492561
128MP0000249_abnormal_blood_vessel0.73354721
129MP0001348_abnormal_lacrimal_gland0.71921118
130MP0002128_abnormal_blood_circulation0.71220513
131MP0000750_abnormal_muscle_regeneration0.70829914
132MP0001346_abnormal_lacrimal_gland0.70534448
133MP0002572_abnormal_emotion/affect_behav0.70217647
134MP0000747_muscle_weakness0.69700693
135MP0005197_abnormal_uvea_morphology0.69182718
136MP0001216_abnormal_epidermal_layer0.68560950
137MP0000428_abnormal_craniofacial_morphol0.68139727
138MP0002064_seizures0.67910259
139MP0001501_abnormal_sleep_pattern0.67287824
140MP0002089_abnormal_postnatal_growth/wei0.67056521
141MP0003868_abnormal_feces_composition0.66755160
142MP0005166_decreased_susceptibility_to0.66496010
143MP0005388_respiratory_system_phenotype0.65418308
144MP0002133_abnormal_respiratory_system0.65418308
145MP0001851_eye_inflammation0.65210739
146MP0002796_impaired_skin_barrier0.63088944
147MP0002933_joint_inflammation0.61196724
148* MP0002925_abnormal_cardiovascular_devel0.60509304
149MP0006082_CNS_inflammation0.59754728
150MP0000467_abnormal_esophagus_morphology0.59615452
151* MP0000432_abnormal_head_morphology0.58964433

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.48585524
2Premature rupture of membranes (HP:0001788)5.25493389
3Menorrhagia (HP:0000132)3.96749092
4Shallow orbits (HP:0000586)3.93467285
5Increased mean platelet volume (HP:0011877)3.84182273
6Abnormal platelet volume (HP:0011876)3.41769733
7Atrophic scars (HP:0001075)3.31617150
8Overgrowth (HP:0001548)3.20721284
9Spondylolisthesis (HP:0003302)3.19836183
10Cerebral aneurysm (HP:0004944)3.19713756
11Mitral stenosis (HP:0001718)3.10833999
12Broad metatarsal (HP:0001783)3.00163837
13Coronal craniosynostosis (HP:0004440)2.93386321
14Osteolytic defects of the hand bones (HP:0009699)2.91329879
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.91329879
16Aortic dissection (HP:0002647)2.88313458
17Abnormality of liposaccharide metabolism (HP:0010968)2.81062665
18Abnormality of glycosphingolipid metabolism (HP:0004343)2.81062665
19Abnormality of glycolipid metabolism (HP:0010969)2.81062665
20Urinary glycosaminoglycan excretion (HP:0003541)2.79386095
21Mucopolysacchariduria (HP:0008155)2.79386095
22Dysostosis multiplex (HP:0000943)2.76408715
23Fragile skin (HP:0001030)2.75823521
24Purpura (HP:0000979)2.67901889
25Abnormality of polysaccharide metabolism (HP:0011012)2.64456893
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64456893
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64456893
28Hyperextensible skin (HP:0000974)2.64156381
29Aplasia involving bones of the upper limbs (HP:0009823)2.62098807
30Aplasia of the phalanges of the hand (HP:0009802)2.62098807
31Aplasia involving bones of the extremities (HP:0009825)2.62098807
32Prolonged bleeding time (HP:0003010)2.59198099
33Peritonitis (HP:0002586)2.57895225
34Soft skin (HP:0000977)2.57466870
35Mitral valve prolapse (HP:0001634)2.53755123
36Type 1 muscle fiber predominance (HP:0003803)2.49602887
37Buphthalmos (HP:0000557)2.48872144
38Abnormality of dentin (HP:0010299)2.48516867
39Genu recurvatum (HP:0002816)2.45244523
40Aortic aneurysm (HP:0004942)2.43575889
41Petechiae (HP:0000967)2.41439859
42Ankle contracture (HP:0006466)2.41237246
43Turricephaly (HP:0000262)2.40346983
44Dilatation of the ascending aorta (HP:0005111)2.39254060
45Increased connective tissue (HP:0009025)2.37973895
46Cardiovascular calcification (HP:0011915)2.37040948
47Mildly elevated creatine phosphokinase (HP:0008180)2.36662622
48Natal tooth (HP:0000695)2.36365863
49Vascular tortuosity (HP:0004948)2.34182015
50Gingival bleeding (HP:0000225)2.33717890
51Aortic regurgitation (HP:0001659)2.31739322
52Epistaxis (HP:0000421)2.31239509
53Morphological abnormality of the middle ear (HP:0008609)2.29586194
54Blue sclerae (HP:0000592)2.28821145
55Wormian bones (HP:0002645)2.28215713
56Abnormality of the acetabulum (HP:0003170)2.26919861
57Bladder diverticulum (HP:0000015)2.26106857
58Neonatal short-limb short stature (HP:0008921)2.25163022
59Follicular hyperkeratosis (HP:0007502)2.24281520
60* Spinal rigidity (HP:0003306)2.23302723
61Arterial tortuosity (HP:0005116)2.23113281
62Wide anterior fontanel (HP:0000260)2.22494478
63Thoracolumbar scoliosis (HP:0002944)2.21854645
64Conjunctival telangiectasia (HP:0000524)2.19597482
65Absent frontal sinuses (HP:0002688)2.17649598
66Achilles tendon contracture (HP:0001771)2.14495007
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13423149
68Bronchomalacia (HP:0002780)2.12450371
69Ovoid vertebral bodies (HP:0003300)2.11877440
70Cervical subluxation (HP:0003308)2.09638526
71Right ventricular cardiomyopathy (HP:0011663)2.06458326
72Congenital glaucoma (HP:0001087)2.05821333
73Abnormality of the Achilles tendon (HP:0005109)2.05132543
74Nuclear cataract (HP:0100018)2.05116078
75Abnormality of the common coagulation pathway (HP:0010990)2.05065033
76Vertebral arch anomaly (HP:0008438)2.05034831
77Distal lower limb amyotrophy (HP:0008944)2.04504914
78Aneurysm (HP:0002617)2.03722522
79Abnormality of the ischium (HP:0003174)2.01950673
80Hypoplastic ischia (HP:0003175)1.98512094
81Infantile muscular hypotonia (HP:0008947)1.96772572
82Lower limb amyotrophy (HP:0007210)1.96467822
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95712189
84Aortic valve stenosis (HP:0001650)1.95105830
85Difficulty climbing stairs (HP:0003551)1.94484862
86Hyperlipoproteinemia (HP:0010980)1.93924299
87Increased variability in muscle fiber diameter (HP:0003557)1.93852617
88J-shaped sella turcica (HP:0002680)1.93058787
89Joint stiffness (HP:0001387)1.92628832
90Asymmetric septal hypertrophy (HP:0001670)1.91775755
91Long toe (HP:0010511)1.91596935
92Distal lower limb muscle weakness (HP:0009053)1.91341675
93Round ear (HP:0100830)1.87398891
94Alopecia of scalp (HP:0002293)1.86902555
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86496344
96Vacuolated lymphocytes (HP:0001922)1.84844019
97Bruising susceptibility (HP:0000978)1.83946788
98Scapular winging (HP:0003691)1.83759869
99Spontaneous hematomas (HP:0007420)1.83268965
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83230641
101Vascular calcification (HP:0004934)1.81824966
102Venous abnormality (HP:0002624)1.81757841
103Elbow flexion contracture (HP:0002987)1.81411438
104Bowel diverticulosis (HP:0005222)1.81313608
105Slender build (HP:0001533)1.81064025
106Asymmetry of the thorax (HP:0001555)1.80796325
107Thin bony cortex (HP:0002753)1.79813403
108Biconcave vertebral bodies (HP:0004586)1.79540735
109Focal motor seizures (HP:0011153)1.78705491
110Vertebral compression fractures (HP:0002953)1.78654049
111Broad ribs (HP:0000885)1.76633842
112Focal seizures (HP:0007359)1.76556991
113Wrist flexion contracture (HP:0001239)1.74786211
114Cerebral inclusion bodies (HP:0100314)1.74547849
115Deep venous thrombosis (HP:0002625)1.74352541
116Abnormality of skull ossification (HP:0002703)1.73786508
117Genetic anticipation (HP:0003743)1.73663542
118Striae distensae (HP:0001065)1.69895758
119Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68743207
120Flared iliac wings (HP:0002869)1.68309974
121Abnormal delivery (HP:0001787)1.68279706
122Upper limb amyotrophy (HP:0009129)1.67837005
123Distal upper limb amyotrophy (HP:0007149)1.67837005
124Osteopenia (HP:0000938)1.67418795
125Hypercortisolism (HP:0001578)1.67063726
126Hypoplasia of the iris (HP:0007676)1.66518300
127Femoral bowing (HP:0002980)1.66036444
128Joint laxity (HP:0001388)1.66001857
129Venous insufficiency (HP:0005293)1.65951911
130Myocardial infarction (HP:0001658)1.65722928
131Hypoventilation (HP:0002791)1.64088096
132Choanal stenosis (HP:0000452)1.63666083
133Camptodactyly of toe (HP:0001836)1.63190964
134* Deviation of the hallux (HP:0010051)1.62792688
135Short nail (HP:0001799)1.62701596
136Abnormality of the calf musculature (HP:0001430)1.62634179
137Hepatoblastoma (HP:0002884)1.61314340
138Abnormality of skeletal muscle fiber size (HP:0012084)1.60532159
139Osteoarthritis (HP:0002758)1.59087295
140Lymphangioma (HP:0100764)1.56526726
141Enlarged penis (HP:0000040)1.54260730
142Abnormality of the nasal septum (HP:0000419)1.53381305
143Agitation (HP:0000713)1.53215163
144Atonic seizures (HP:0010819)1.52585314
145Ectopia lentis (HP:0001083)1.52449228
146* Hallux valgus (HP:0001822)1.52172405
147Ulnar bowing (HP:0003031)1.51559549
148Action tremor (HP:0002345)1.51488900
149Knee flexion contracture (HP:0006380)1.50776118
150Obstructive sleep apnea (HP:0002870)1.48818903
151Macroorchidism (HP:0000053)1.48742907
152Sudden death (HP:0001699)1.47932755
153Mesomelia (HP:0003027)1.47632725
154Protruding ear (HP:0000411)1.47024962
155Subacute progressive viral hepatitis (HP:0006572)1.45276998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.90534046
2DDR23.77462609
3BCKDK2.90978286
4PDGFRA2.62107400
5EPHA42.58966060
6LATS22.41277588
7TRIB32.34256986
8EPHB22.24741149
9FER2.16013193
10IRAK32.14361807
11NTRK32.06975136
12LATS12.03808166
13DMPK2.00191639
14PIK3CG1.97871630
15PRKD31.97377921
16PTK2B1.96312434
17NEK91.95720590
18SIK11.84768651
19PAK41.77105945
20LMTK21.73323499
21MST41.61105259
22ZAP701.60488619
23TTN1.59537022
24MAPK151.58160860
25RIPK11.55113193
26PTK21.48293436
27NTRK11.47646657
28STK241.43349965
29TESK11.42656065
30BMX1.41148506
31PAK31.38800639
32PLK21.38614877
33MAP3K91.38471267
34PAK61.36285157
35AKT31.30337594
36MOS1.29812132
37MARK11.20441815
38ERN11.19647933
39MINK11.19280675
40ICK1.16280772
41MAP3K61.15377167
42PKN21.14486010
43MAP2K41.11317180
44MAP3K41.09263445
45EPHA31.08670624
46KSR21.08170181
47GRK71.08088129
48MAP3K21.07525786
49FGR1.06902608
50PRKG21.05531972
51TGFBR11.04531868
52EPHB11.04319521
53PTK61.03395295
54ERBB31.03136026
55KSR11.02932261
56ABL21.00767731
57PAK20.99580206
58MAP2K10.98199358
59CAMKK10.97377437
60EIF2AK30.96169946
61TYRO30.94686074
62RET0.94576548
63SIK20.93529716
64CAMK2A0.91550387
65FGFR20.91405596
66MAP2K30.89214997
67PHKG10.88351049
68PHKG20.88351049
69ROCK20.87811893
70PIM20.87039072
71PDGFRB0.86119457
72MET0.85097584
73TGFBR20.83800565
74TAOK20.83165863
75FRK0.81832860
76PRKD20.80938026
77CAMK1G0.80827786
78BCR0.79971665
79FGFR10.79727281
80MAP3K120.79127219
81MAP3K30.78917418
82DAPK20.77619167
83CDK60.77504126
84CDC42BPA0.76168890
85MARK20.76040827
86PRKCE0.75966238
87ILK0.75789751
88PRKCH0.75114874
89FGFR30.73953035
90MAP3K70.73401765
91DYRK1B0.72940757
92GSK3A0.72800162
93SCYL20.72633512
94PIK3CA0.72544510
95CDK50.72457433
96CAMK2D0.72202093
97TRPM70.71905467
98ARAF0.68407792
99JAK10.68146157
100GRK50.67331971
101CAMK2B0.67271605
102TEC0.67253966
103EPHA20.67192169
104TBK10.66606042
105CAMK1D0.65854654
106TYK20.65426699
107MST1R0.65047223
108TIE10.64170288
109MAP3K10.63510248
110MAPKAPK30.62666527
111STK38L0.61990280
112CAMKK20.61008112
113PRKD10.60645020
114WNK10.59931353
115FLT30.57398003
116TAOK10.56847199
117BMPR20.56734482
118NTRK20.56575998
119MAP3K140.55838998
120INSRR0.55606218
121CDK140.53999231
122MAP3K130.53905902
123SGK10.53277888
124ROCK10.52324239
125CDK80.51742785
126INSR0.51463076
127STK380.50471631
128PRPF4B0.49949744
129UHMK10.49872036
130FGFR40.48754485
131MAPK120.48370283
132JAK30.48128788
133NLK0.46813325
134MATK0.46574520
135SIK30.46549044
136MELK0.46405391
137MTOR0.46399415
138KIT0.46170694
139ABL10.45972333
140STK30.45967521
141PRKCG0.45846135
142DAPK30.45655656
143ADRBK10.45252348
144LIMK10.44958436
145SRC0.44142694
146PNCK0.44119010
147ERBB40.43988638
148SGK20.43652498
149BMPR1B0.41212459
150CSK0.41076261
151PAK10.38056868
152RPS6KA20.36873398
153MAPK70.35137653

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.80307450
2Other glycan degradation_Homo sapiens_hsa005112.14157212
3ECM-receptor interaction_Homo sapiens_hsa045121.92733631
4Lysosome_Homo sapiens_hsa041421.89868557
5Sulfur metabolism_Homo sapiens_hsa009201.62338227
6Dilated cardiomyopathy_Homo sapiens_hsa054141.60599484
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59433273
8Focal adhesion_Homo sapiens_hsa045101.57634419
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54828637
10Adherens junction_Homo sapiens_hsa045201.52161526
11Malaria_Homo sapiens_hsa051441.49549783
12Circadian entrainment_Homo sapiens_hsa047131.48471393
13Long-term potentiation_Homo sapiens_hsa047201.44738090
14Small cell lung cancer_Homo sapiens_hsa052221.44670009
15Nicotine addiction_Homo sapiens_hsa050331.43521522
16Amphetamine addiction_Homo sapiens_hsa050311.43175881
17Axon guidance_Homo sapiens_hsa043601.41928817
18Nitrogen metabolism_Homo sapiens_hsa009101.37038675
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35352899
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33856156
21Glutamatergic synapse_Homo sapiens_hsa047241.32374176
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30606151
23Long-term depression_Homo sapiens_hsa047301.29799002
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28740706
25Sphingolipid metabolism_Homo sapiens_hsa006001.28555025
26GABAergic synapse_Homo sapiens_hsa047271.28109137
27Renin secretion_Homo sapiens_hsa049241.27535811
28Gap junction_Homo sapiens_hsa045401.24790273
29Salivary secretion_Homo sapiens_hsa049701.24640428
30Proteoglycans in cancer_Homo sapiens_hsa052051.24638863
31Insulin secretion_Homo sapiens_hsa049111.22873104
32Dopaminergic synapse_Homo sapiens_hsa047281.20538757
33GnRH signaling pathway_Homo sapiens_hsa049121.19581545
34Hippo signaling pathway_Homo sapiens_hsa043901.18614057
35Amoebiasis_Homo sapiens_hsa051461.18349124
36Melanogenesis_Homo sapiens_hsa049161.17324632
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17074222
38Glioma_Homo sapiens_hsa052141.16587773
39Oxytocin signaling pathway_Homo sapiens_hsa049211.15014254
40Estrogen signaling pathway_Homo sapiens_hsa049151.14022959
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13394829
42Cholinergic synapse_Homo sapiens_hsa047251.09210289
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.08898104
44Cocaine addiction_Homo sapiens_hsa050301.08443787
45TNF signaling pathway_Homo sapiens_hsa046681.06583560
46Pertussis_Homo sapiens_hsa051331.06359878
47Gastric acid secretion_Homo sapiens_hsa049711.05470878
48Morphine addiction_Homo sapiens_hsa050321.04194712
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03640692
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03275474
51Bladder cancer_Homo sapiens_hsa052191.02615302
52Dorso-ventral axis formation_Homo sapiens_hsa043200.98172947
53* TGF-beta signaling pathway_Homo sapiens_hsa043500.98062484
54Hedgehog signaling pathway_Homo sapiens_hsa043400.97165022
55Circadian rhythm_Homo sapiens_hsa047100.96969054
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96837087
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96228976
58Endocytosis_Homo sapiens_hsa041440.95834039
59Phagosome_Homo sapiens_hsa041450.95663768
60Serotonergic synapse_Homo sapiens_hsa047260.95594774
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95056607
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94844834
63Bile secretion_Homo sapiens_hsa049760.93793741
64Rap1 signaling pathway_Homo sapiens_hsa040150.93437248
65Shigellosis_Homo sapiens_hsa051310.92358942
66Wnt signaling pathway_Homo sapiens_hsa043100.92291162
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92128628
68Olfactory transduction_Homo sapiens_hsa047400.91813706
69cAMP signaling pathway_Homo sapiens_hsa040240.91662761
70Basal cell carcinoma_Homo sapiens_hsa052170.91416529
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90588320
72Osteoclast differentiation_Homo sapiens_hsa043800.90093496
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89957928
74Chronic myeloid leukemia_Homo sapiens_hsa052200.89550626
75Fatty acid biosynthesis_Homo sapiens_hsa000610.88717088
76Protein digestion and absorption_Homo sapiens_hsa049740.86060638
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85496622
78Prion diseases_Homo sapiens_hsa050200.85369841
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.85044854
80Arginine biosynthesis_Homo sapiens_hsa002200.84814364
81Melanoma_Homo sapiens_hsa052180.84534394
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84350417
83ErbB signaling pathway_Homo sapiens_hsa040120.82753134
84Synaptic vesicle cycle_Homo sapiens_hsa047210.81776288
85Type II diabetes mellitus_Homo sapiens_hsa049300.81580508
86Pathways in cancer_Homo sapiens_hsa052000.81575462
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80645724
88Calcium signaling pathway_Homo sapiens_hsa040200.79629309
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79540527
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.79025332
91Complement and coagulation cascades_Homo sapiens_hsa046100.78385097
92Thyroid hormone synthesis_Homo sapiens_hsa049180.76896704
93Ovarian steroidogenesis_Homo sapiens_hsa049130.76529992
94Pancreatic cancer_Homo sapiens_hsa052120.76440928
95Renal cell carcinoma_Homo sapiens_hsa052110.76082213
96Salmonella infection_Homo sapiens_hsa051320.76071952
97VEGF signaling pathway_Homo sapiens_hsa043700.75924377
98Tight junction_Homo sapiens_hsa045300.74958147
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71788994
100Mineral absorption_Homo sapiens_hsa049780.70656275
101Choline metabolism in cancer_Homo sapiens_hsa052310.70079518
102Ras signaling pathway_Homo sapiens_hsa040140.70053027
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69510059
104Toxoplasmosis_Homo sapiens_hsa051450.68746192
105Thyroid cancer_Homo sapiens_hsa052160.68152293
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.67940278
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67539688
108Taste transduction_Homo sapiens_hsa047420.67366388
109Galactose metabolism_Homo sapiens_hsa000520.66723921
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66431256
111MAPK signaling pathway_Homo sapiens_hsa040100.66273253
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66110646
113Hematopoietic cell lineage_Homo sapiens_hsa046400.65071047
114Prostate cancer_Homo sapiens_hsa052150.64436578
115mTOR signaling pathway_Homo sapiens_hsa041500.64347139
116Glucagon signaling pathway_Homo sapiens_hsa049220.64263379
117Starch and sucrose metabolism_Homo sapiens_hsa005000.63885275
118Rheumatoid arthritis_Homo sapiens_hsa053230.63284249
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.61332655
120MicroRNAs in cancer_Homo sapiens_hsa052060.60887777
121* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59221821
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59016293
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58431083
124Collecting duct acid secretion_Homo sapiens_hsa049660.57360500
125Caffeine metabolism_Homo sapiens_hsa002320.56098522
126* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56022866
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54824105
128Endometrial cancer_Homo sapiens_hsa052130.54437458
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53217902
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52899388
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52855101
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52769615
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52749331
134N-Glycan biosynthesis_Homo sapiens_hsa005100.51612998
135Vibrio cholerae infection_Homo sapiens_hsa051100.50917837
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.49789548
137Notch signaling pathway_Homo sapiens_hsa043300.49643804
138Insulin resistance_Homo sapiens_hsa049310.48677347
139Platelet activation_Homo sapiens_hsa046110.48165046
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47984618
141Pancreatic secretion_Homo sapiens_hsa049720.47462626
142Hepatitis C_Homo sapiens_hsa051600.46913673
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.45835387
144Inositol phosphate metabolism_Homo sapiens_hsa005620.43299974
145Chemokine signaling pathway_Homo sapiens_hsa040620.41910075
146Renin-angiotensin system_Homo sapiens_hsa046140.41311949
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.39718680
148Acute myeloid leukemia_Homo sapiens_hsa052210.39515084

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