ACTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.81937385
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87669761
3neutrophil activation (GO:0042119)4.30369969
4positive regulation of interferon-alpha production (GO:0032727)4.28602140
5respiratory burst (GO:0045730)4.23240133
6granulocyte activation (GO:0036230)4.13286126
7response to peptidoglycan (GO:0032494)4.13032246
8regulation of interferon-alpha production (GO:0032647)4.07499677
9immunoglobulin mediated immune response (GO:0016064)3.97595065
10production of molecular mediator involved in inflammatory response (GO:0002532)3.85840527
11hydrogen peroxide biosynthetic process (GO:0050665)3.80102319
12superoxide anion generation (GO:0042554)3.78261410
13reactive oxygen species biosynthetic process (GO:1903409)3.77660877
14detection of molecule of bacterial origin (GO:0032490)3.75258142
15cellular extravasation (GO:0045123)3.74752335
16interferon-gamma-mediated signaling pathway (GO:0060333)3.73000578
17detection of other organism (GO:0098543)3.66046989
18regulation of B cell receptor signaling pathway (GO:0050855)3.61379255
19protein localization to endosome (GO:0036010)3.61359155
20negative regulation of erythrocyte differentiation (GO:0045647)3.59032536
21modulation by symbiont of host defense response (GO:0052031)3.57953108
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57953108
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57953108
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.57953108
25modulation by symbiont of host immune response (GO:0052553)3.57953108
26positive regulation by symbiont of host defense response (GO:0052509)3.57953108
27positive regulation of monocyte chemotaxis (GO:0090026)3.56774130
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53272769
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47373771
30myeloid dendritic cell activation (GO:0001773)3.47266346
31positive regulation of antigen processing and presentation (GO:0002579)3.47003606
32cellular response to type I interferon (GO:0071357)3.45727892
33type I interferon signaling pathway (GO:0060337)3.45727892
34regulation of gamma-delta T cell activation (GO:0046643)3.42428677
35response to type I interferon (GO:0034340)3.40525140
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.39771337
37B cell receptor signaling pathway (GO:0050853)3.37593164
38detection of external biotic stimulus (GO:0098581)3.35816493
39regulation of T-helper 1 cell differentiation (GO:0045625)3.35545831
40positive regulation of mast cell activation (GO:0033005)3.34240279
41natural killer cell mediated immunity (GO:0002228)3.34212948
42natural killer cell mediated cytotoxicity (GO:0042267)3.34212948
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34182733
44defense response to protozoan (GO:0042832)3.33496220
45myeloid cell activation involved in immune response (GO:0002275)3.32219953
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29488813
47negative regulation of viral genome replication (GO:0045071)3.28762436
48leukocyte aggregation (GO:0070486)3.27276580
49detection of bacterium (GO:0016045)3.25836947
50cellular response to exogenous dsRNA (GO:0071360)3.25620363
51positive regulation of interleukin-12 production (GO:0032735)3.25451755
52mast cell activation (GO:0045576)3.25292025
53response to host (GO:0075136)3.25253490
54response to host defenses (GO:0052200)3.25253490
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25253490
56regulation of RIG-I signaling pathway (GO:0039535)3.24840497
57B cell mediated immunity (GO:0019724)3.24448915
58sequestering of actin monomers (GO:0042989)3.24399117
59negative regulation of interleukin-12 production (GO:0032695)3.22984487
60cellular response to zinc ion (GO:0071294)3.22980396
61negative regulation of interleukin-17 production (GO:0032700)3.22865255
62positive regulation of B cell differentiation (GO:0045579)3.21261657
63positive regulation of cellular amide metabolic process (GO:0034250)3.20245123
64regulation of alpha-beta T cell proliferation (GO:0046640)3.19936120
65dendritic cell chemotaxis (GO:0002407)3.19595742
66antigen processing and presentation of endogenous antigen (GO:0019883)3.19455579
67cellular response to interferon-beta (GO:0035458)3.15266873
68regulation of gamma-delta T cell differentiation (GO:0045586)3.15157738
69myeloid dendritic cell differentiation (GO:0043011)3.13949242
70regulation of activation of Janus kinase activity (GO:0010533)3.13591673
71leukocyte mediated cytotoxicity (GO:0001909)3.13369317
72hypotonic response (GO:0006971)3.13002724
73regulation of mast cell activation (GO:0033003)3.11608439
74positive regulation of T cell chemotaxis (GO:0010820)3.10580669
75regulation of T cell chemotaxis (GO:0010819)3.10580669
76T cell migration (GO:0072678)3.10366552
77regulation of interferon-beta biosynthetic process (GO:0045357)3.10022327
78positive regulation of lymphocyte migration (GO:2000403)3.08735380
79negative regulation of cell killing (GO:0031342)3.08157084
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08157084
81positive regulation of interferon-beta production (GO:0032728)3.07747951
82positive regulation of mast cell degranulation (GO:0043306)3.07468411
83positive regulation of mast cell activation involved in immune response (GO:0033008)3.07468411
84positive regulation of T cell migration (GO:2000406)3.06446569
85regulation of antigen processing and presentation (GO:0002577)3.04446925
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03927473
87pinocytosis (GO:0006907)3.02997497
88macrophage activation involved in immune response (GO:0002281)3.02885153
89negative regulation of mast cell activation (GO:0033004)3.01891172
90myeloid leukocyte activation (GO:0002274)3.01056024
91dendritic cell migration (GO:0036336)2.99960903
92eosinophil chemotaxis (GO:0048245)2.99475369
93antigen processing and presentation via MHC class Ib (GO:0002475)2.98806246
94T-helper 1 type immune response (GO:0042088)2.98499836
95response to protozoan (GO:0001562)2.97518036
96detection of biotic stimulus (GO:0009595)2.97420863
97positive regulation of gamma-delta T cell activation (GO:0046645)2.95254164
98regulation of leukocyte degranulation (GO:0043300)2.93150176
99monocyte chemotaxis (GO:0002548)2.92854734
100negative thymic T cell selection (GO:0045060)2.92391652
101positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91905937
102positive regulation of type 2 immune response (GO:0002830)2.90300353
103regulation of mast cell degranulation (GO:0043304)2.90090944
104leukocyte degranulation (GO:0043299)2.89737412
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89534700
106interferon-gamma production (GO:0032609)2.87163251
107lymphocyte chemotaxis (GO:0048247)2.86518357
108response to muramyl dipeptide (GO:0032495)2.84917606
109cellular response to interferon-gamma (GO:0071346)2.84537506
110positive regulation of natural killer cell differentiation (GO:0032825)2.84278431
111regulation of lymphocyte chemotaxis (GO:1901623)2.84094039
112response to host immune response (GO:0052572)2.83885147
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83885147
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83688619
115germinal center formation (GO:0002467)2.83533034
116positive regulation of macrophage differentiation (GO:0045651)2.82972042
117phagosome maturation (GO:0090382)2.82745680
118regulation of B cell differentiation (GO:0045577)2.82223245
119positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80819999
120histamine secretion (GO:0001821)2.80407399
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80325884
122regulation of monocyte chemotaxis (GO:0090025)2.80280005
123regulation of hypersensitivity (GO:0002883)2.79252402
124positive thymic T cell selection (GO:0045059)2.77425477
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.77097475
126negative T cell selection (GO:0043383)2.76626354
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.76611878
128regulation of macrophage cytokine production (GO:0010935)2.74953105
129negative regulation of T cell mediated immunity (GO:0002710)2.73398947
130response to interleukin-15 (GO:0070672)2.72868998
131response to laminar fluid shear stress (GO:0034616)2.72602616
132embryonic process involved in female pregnancy (GO:0060136)2.69475029
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68668538
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67521042
135membrane raft organization (GO:0031579)2.66174740
136macrophage activation (GO:0042116)2.65557665
137microglial cell activation (GO:0001774)2.65066676
138stress fiber assembly (GO:0043149)2.62677560
139hepatocyte apoptotic process (GO:0097284)2.61222682
140cortical actin cytoskeleton organization (GO:0030866)2.60419621
141positive regulation of leukocyte degranulation (GO:0043302)2.59923248
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.58093444
143regulation of T-helper 2 cell differentiation (GO:0045628)2.57104358
144regulation of mast cell activation involved in immune response (GO:0033006)2.56111236
145Golgi transport vesicle coating (GO:0048200)2.52792003
146COPI coating of Golgi vesicle (GO:0048205)2.52792003
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51830083
148T cell selection (GO:0045058)2.50054178
149nuclear pore complex assembly (GO:0051292)2.46753616
150regulation of tolerance induction (GO:0002643)2.45669289
151megakaryocyte development (GO:0035855)2.42094502
152regulation of regulated secretory pathway (GO:1903305)2.41256837
153regulation of defense response to virus by virus (GO:0050690)2.40606480
154negative regulation of leukocyte mediated immunity (GO:0002704)2.40495612
155regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40119080
156positive regulation of macrophage cytokine production (GO:0060907)2.39565526
157thymic T cell selection (GO:0045061)2.39262231
158regulation of T cell tolerance induction (GO:0002664)2.38019800
159JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37129389
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37104429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.05984800
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.81330049
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.31757316
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15215950
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.84543483
6E2F7_22180533_ChIP-Seq_HELA_Human4.39625749
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05375025
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.96114637
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.78832493
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59792201
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.38397231
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22020094
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14222691
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.12055769
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00051963
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.96190083
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92181073
18MYC_22102868_ChIP-Seq_BL_Human2.83458374
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82731810
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22804202
21* SPI1_23547873_ChIP-Seq_NB4_Human2.17944870
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.11384606
23VDR_21846776_ChIP-Seq_THP-1_Human2.09397385
24RUNX_20019798_ChIP-Seq_JUKART_Human2.03554636
25MYB_26560356_Chip-Seq_TH2_Human2.00262061
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96764478
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95614116
28TCF7_22412390_ChIP-Seq_EML_Mouse1.95241944
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.90862061
30CLOCK_20551151_ChIP-Seq_293T_Human1.87057892
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79403890
32* PU_27001747_Chip-Seq_BMDM_Mouse1.72986000
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72319956
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62684312
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62475485
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62056823
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61811395
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.57409303
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56206328
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51943947
41ELK1_19687146_ChIP-ChIP_HELA_Human1.51296993
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49903663
43* MYB_26560356_Chip-Seq_TH1_Human1.49527349
44UTX_26944678_Chip-Seq_JUKART_Human1.48331035
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46993066
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46908334
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46658055
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46097370
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44883332
50GATA1_22025678_ChIP-Seq_K562_Human1.43166797
51VDR_24787735_ChIP-Seq_THP-1_Human1.42485452
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41226513
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.40867653
54KDM2B_26808549_Chip-Seq_DND41_Human1.39328530
55GATA3_26560356_Chip-Seq_TH2_Human1.38803880
56* RUNX1_22412390_ChIP-Seq_EML_Mouse1.37354738
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35626295
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33143189
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32669639
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32203123
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31499146
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31032019
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.30499193
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29007673
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26578311
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24978373
67* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24092180
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20709523
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20532873
70* SPI1_23127762_ChIP-Seq_K562_Human1.19904721
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19233647
72VDR_24763502_ChIP-Seq_THP-1_Human1.19147643
73* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18334607
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17860812
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17380470
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16341341
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16228362
78MAF_26560356_Chip-Seq_TH1_Human1.15774064
79GATA3_27048872_Chip-Seq_THYMUS_Human1.13160459
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11837104
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.11565977
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10517761
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.10200467
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.08599130
85NCOR1_26117541_ChIP-Seq_K562_Human1.08297421
86MAF_26560356_Chip-Seq_TH2_Human1.07635784
87GATA1_19941826_ChIP-Seq_K562_Human1.06093041
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04509856
89* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04375664
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.03731629
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02974563
92SCL_19346495_ChIP-Seq_HPC-7_Human1.02402422
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01302210
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99075869
95* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98771771
96* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98520303
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98457691
98* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98384204
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98119927
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97170518
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97109050
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96824304
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94981689
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94546779
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94458713
106GATA2_19941826_ChIP-Seq_K562_Human0.93786135
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91270122
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90931249
109* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90369378
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89398880
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88633221
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.88335988
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87323774
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86183067
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82568638
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81901436
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81630240
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81630240
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80928043
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.79198493
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79158432
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79158432
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.77441875
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76013825
125PU1_27457419_Chip-Seq_LIVER_Mouse0.75622659
126P53_22387025_ChIP-Seq_ESCs_Mouse0.75144592
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.74208002
128* SMRT_27268052_Chip-Seq_Bcells_Human0.73454797
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.73214041
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72696344
131EGR1_19032775_ChIP-ChIP_M12_Human0.72211858
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71604078
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.71286640
134* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.70129498
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.69968962
136SALL4_22934838_ChIP-ChIP_CD34+_Human0.69889033
137TFEB_21752829_ChIP-Seq_HELA_Human0.69470915
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.69097685
139* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67041383
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.66862767
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66677413
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66249070
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66097454
144SOX2_20726797_ChIP-Seq_SW620_Human0.65225120
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.64484540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.41329975
2MP0002148_abnormal_hypersensitivity_rea4.12964912
3MP0009785_altered_susceptibility_to3.98460619
4MP0005671_abnormal_response_to3.48556694
5MP0003436_decreased_susceptibility_to3.46127786
6MP0005000_abnormal_immune_tolerance3.25514908
7MP0003300_gastrointestinal_ulcer3.11401959
8MP0002419_abnormal_innate_immunity3.07579955
9MP0001790_abnormal_immune_system2.90831331
10MP0005387_immune_system_phenotype2.90831331
11MP0005025_abnormal_response_to2.88935108
12MP0002452_abnormal_antigen_presenting2.73604301
13MP0000685_abnormal_immune_system2.65061159
14MP0003724_increased_susceptibility_to2.64673860
15MP0001800_abnormal_humoral_immune2.62186715
16MP0006082_CNS_inflammation2.56106574
17MP0002723_abnormal_immune_serum2.53188609
18MP0003705_abnormal_hypodermis_morpholog2.49977986
19MP0001819_abnormal_immune_cell2.49074280
20MP0002420_abnormal_adaptive_immunity2.46385298
21MP0002006_tumorigenesis2.18765330
22MP0003303_peritoneal_inflammation2.17973470
23MP0008260_abnormal_autophagy2.15935464
24MP0005451_abnormal_body_composition2.07067949
25MP0005464_abnormal_platelet_physiology1.97605527
26MP0002405_respiratory_system_inflammati1.96063450
27MP0004782_abnormal_surfactant_physiolog1.93156667
28MP0002166_altered_tumor_susceptibility1.89393755
29MP0002398_abnormal_bone_marrow1.89251011
30MP0000716_abnormal_immune_system1.81928584
31MP0008438_abnormal_cutaneous_collagen1.80469570
32MP0001845_abnormal_inflammatory_respons1.78702380
33MP0003448_altered_tumor_morphology1.78475550
34MP0005310_abnormal_salivary_gland1.76263362
35MP0004510_myositis1.74815794
36MP0000858_altered_metastatic_potential1.72128101
37MP0001533_abnormal_skeleton_physiology1.71356041
38MP0010234_abnormal_vibrissa_follicle1.70313045
39MP0009333_abnormal_splenocyte_physiolog1.65515018
40MP0001853_heart_inflammation1.62390990
41MP0009764_decreased_sensitivity_to1.62361276
42MP0010155_abnormal_intestine_physiology1.61436092
43MP0003763_abnormal_thymus_physiology1.59988269
44MP0000343_altered_response_to1.47801987
45MP0000569_abnormal_digit_pigmentation1.44447975
46MP0002429_abnormal_blood_cell1.44374800
47MP0000689_abnormal_spleen_morphology1.43911547
48MP0005397_hematopoietic_system_phenotyp1.41933946
49MP0001545_abnormal_hematopoietic_system1.41933946
50MP0010307_abnormal_tumor_latency1.40072778
51MP0000015_abnormal_ear_pigmentation1.37665639
52MP0001958_emphysema1.37533189
53MP0005409_darkened_coat_color1.35435216
54MP0002722_abnormal_immune_system1.33659533
55MP0008469_abnormal_protein_level1.31182613
56MP0001851_eye_inflammation1.29701777
57MP0002396_abnormal_hematopoietic_system1.29449643
58MP0004947_skin_inflammation1.27072342
59MP0003075_altered_response_to1.26084511
60MP0003172_abnormal_lysosome_physiology1.26043281
61MP0005058_abnormal_lysosome_morphology1.25683922
62MP0006054_spinal_hemorrhage1.24375252
63MP0002277_abnormal_respiratory_mucosa1.23480159
64MP0002876_abnormal_thyroid_physiology1.19792091
65MP0002998_abnormal_bone_remodeling1.19201141
66MP0003221_abnormal_cardiomyocyte_apopto1.15434783
67MP0002877_abnormal_melanocyte_morpholog1.14800909
68MP0003186_abnormal_redox_activity1.13316947
69MP0003453_abnormal_keratinocyte_physiol1.11400649
70MP0009278_abnormal_bone_marrow1.10541234
71MP0004808_abnormal_hematopoietic_stem1.08859424
72MP0003656_abnormal_erythrocyte_physiolo1.07629178
73MP0005621_abnormal_cell_physiology1.07601192
74MP0005166_decreased_susceptibility_to1.04668099
75MP0004264_abnormal_extraembryonic_tissu1.02423937
76MP0003279_aneurysm1.02414161
77MP0008057_abnormal_DNA_replication0.97471018
78MP0002009_preneoplasia0.96789746
79MP0005174_abnormal_tail_pigmentation0.95232568
80MP0005023_abnormal_wound_healing0.95056005
81MP0003183_abnormal_peptide_metabolism0.93933268
82MP0000604_amyloidosis0.93400837
83MP0001986_abnormal_taste_sensitivity0.92873529
84MP0001849_ear_inflammation0.92624412
85MP0004185_abnormal_adipocyte_glucose0.90660818
86MP0003191_abnormal_cellular_cholesterol0.89597123
87MP0002163_abnormal_gland_morphology0.89486188
88MP0001348_abnormal_lacrimal_gland0.88781391
89MP0008007_abnormal_cellular_replicative0.87527301
90MP0003690_abnormal_glial_cell0.86987407
91MP0000703_abnormal_thymus_morphology0.85017394
92MP0005167_abnormal_blood-brain_barrier0.84741881
93MP0000767_abnormal_smooth_muscle0.84242154
94MP0002060_abnormal_skin_morphology0.83263253
95MP0005076_abnormal_cell_differentiation0.82343360
96MP0000490_abnormal_crypts_of0.82179636
97MP0008004_abnormal_stomach_pH0.79276654
98MP0005164_abnormal_response_to0.79029588
99MP0001873_stomach_inflammation0.78511373
100MP0002735_abnormal_chemical_nociception0.77261622
101MP0005390_skeleton_phenotype0.76171699
102MP0003795_abnormal_bone_structure0.73727111
103MP0002132_abnormal_respiratory_system0.73632151
104MP0003866_abnormal_defecation0.73052032
105MP0005384_cellular_phenotype0.72593854
106MP0005388_respiratory_system_phenotype0.71952892
107MP0002133_abnormal_respiratory_system0.71952892
108MP0004381_abnormal_hair_follicle0.71328883
109MP0004883_abnormal_blood_vessel0.69990955
110MP0009763_increased_sensitivity_to0.69324884
111MP0001542_abnormal_bone_strength0.69136135
112MP0000465_gastrointestinal_hemorrhage0.68232037
113MP0000371_diluted_coat_color0.67310786
114MP0003566_abnormal_cell_adhesion0.67044848
115MP0002019_abnormal_tumor_incidence0.66497142
116MP0001915_intracranial_hemorrhage0.65256750
117MP0000249_abnormal_blood_vessel0.64702716
118MP0010386_abnormal_urinary_bladder0.63788817
119MP0003787_abnormal_imprinting0.63147882
120MP0003828_pulmonary_edema0.60633875
121MP0005171_absent_coat_pigmentation0.60547774
122MP0003091_abnormal_cell_migration0.60546868
123MP0003943_abnormal_hepatobiliary_system0.59627345
124MP0009697_abnormal_copulation0.58521156
125MP0002138_abnormal_hepatobiliary_system0.57987939
126MP0002095_abnormal_skin_pigmentation0.56953620
127MP0001881_abnormal_mammary_gland0.56503037
128MP0010352_gastrointestinal_tract_polyps0.55397772
129MP0005084_abnormal_gallbladder_morpholo0.53711965
130MP0003693_abnormal_embryo_hatching0.53612685

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.71982737
2Eczematoid dermatitis (HP:0000976)6.19885013
3Recurrent bacterial skin infections (HP:0005406)6.06030810
4Recurrent gram-negative bacterial infections (HP:0005420)4.82026846
5Myositis (HP:0100614)4.61706501
6Mediastinal lymphadenopathy (HP:0100721)4.58726680
7Autoimmune thrombocytopenia (HP:0001973)4.53940783
8Retrobulbar optic neuritis (HP:0100654)4.46296184
9Optic neuritis (HP:0100653)4.46296184
10Orchitis (HP:0100796)4.16081990
11Chronic obstructive pulmonary disease (HP:0006510)4.11298853
12Obstructive lung disease (HP:0006536)4.11298853
13Increased IgM level (HP:0003496)3.96249776
14Abnormality of macrophages (HP:0004311)3.92955071
15Elevated erythrocyte sedimentation rate (HP:0003565)3.83770240
16Recurrent fungal infections (HP:0002841)3.54364251
17Vasculitis (HP:0002633)3.47719073
18Keratoconjunctivitis sicca (HP:0001097)3.46655144
19Recurrent skin infections (HP:0001581)3.45295507
20Gingivitis (HP:0000230)3.37980929
21Recurrent viral infections (HP:0004429)3.28391119
22Systemic lupus erythematosus (HP:0002725)3.25298598
23Keratoconjunctivitis (HP:0001096)3.21884759
24Meningitis (HP:0001287)3.19270294
25Spinal cord lesions (HP:0100561)3.10566300
26Syringomyelia (HP:0003396)3.10566300
27Periodontitis (HP:0000704)3.02661337
28Stomatitis (HP:0010280)3.00702905
29Basal ganglia calcification (HP:0002135)2.99078012
30Recurrent pneumonia (HP:0006532)2.98531902
31Pulmonary infiltrates (HP:0002113)2.95186969
32Cellulitis (HP:0100658)2.88628725
33Agnosia (HP:0010524)2.85917733
34Abnormality of T cell number (HP:0011839)2.85911787
35Arterial thrombosis (HP:0004420)2.83125660
36Prostate neoplasm (HP:0100787)2.81508550
37Hypergammaglobulinemia (HP:0010702)2.73653700
38Peritonitis (HP:0002586)2.71861338
39Vacuolated lymphocytes (HP:0001922)2.70950515
40Abnormality of the prostate (HP:0008775)2.60038657
41Osteomyelitis (HP:0002754)2.59893533
42Leukocytosis (HP:0001974)2.58533755
43Arterial tortuosity (HP:0005116)2.56346278
44Recurrent cutaneous fungal infections (HP:0011370)2.52532702
45Chronic mucocutaneous candidiasis (HP:0002728)2.52532702
46Thyroiditis (HP:0100646)2.52312444
47Eosinophilia (HP:0001880)2.50755391
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.48582780
49Recurrent lower respiratory tract infections (HP:0002783)2.44681685
50T lymphocytopenia (HP:0005403)2.43050172
51Thrombocytosis (HP:0001894)2.42226535
52Encephalitis (HP:0002383)2.40650829
53Gingival bleeding (HP:0000225)2.40487076
54Vascular tortuosity (HP:0004948)2.39381129
55Pustule (HP:0200039)2.38939570
56Gastrointestinal infarctions (HP:0005244)2.38806532
57Hemoptysis (HP:0002105)2.38701257
58Premature rupture of membranes (HP:0001788)2.37457263
59Osteolytic defects of the hand bones (HP:0009699)2.35606958
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.35606958
61Dilatation of the ascending aorta (HP:0005111)2.35256980
62Subacute progressive viral hepatitis (HP:0006572)2.33922576
63Cutaneous melanoma (HP:0012056)2.33305743
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32671841
65Petechiae (HP:0000967)2.32330748
66Abnormal platelet volume (HP:0011876)2.32280661
67Absent frontal sinuses (HP:0002688)2.32240531
68Abnormal hair whorl (HP:0010721)2.31259526
69Abnormality of T cells (HP:0002843)2.30301930
70Autoimmune hemolytic anemia (HP:0001890)2.29417727
71Increased cerebral lipofuscin (HP:0011813)2.26647214
72Viral hepatitis (HP:0006562)2.26414028
73Spondylolisthesis (HP:0003302)2.26015230
74Thick nail (HP:0001805)2.25188762
75Abnormality of the peritoneum (HP:0002585)2.25006335
76Interstitial pulmonary disease (HP:0006530)2.23557432
77Chromsome breakage (HP:0040012)2.23418595
78Protrusio acetabuli (HP:0003179)2.23305925
79IgG deficiency (HP:0004315)2.23183031
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22262165
81Glomerulopathy (HP:0100820)2.22107540
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.20016788
83Sepsis (HP:0100806)2.19231035
84Abnormality of glycolipid metabolism (HP:0010969)2.18903640
85Abnormality of liposaccharide metabolism (HP:0010968)2.18903640
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.18903640
87Poor head control (HP:0002421)2.17962882
88Granulocytopenia (HP:0001913)2.14779754
89Abnormality of eosinophils (HP:0001879)2.14706266
90Epistaxis (HP:0000421)2.14694359
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13753762
92Chronic otitis media (HP:0000389)2.13279936
93Chest pain (HP:0100749)2.12924699
94Ankyloglossia (HP:0010296)2.11395876
95Abnormality of the pleura (HP:0002103)2.11352704
96IgA deficiency (HP:0002720)2.11171443
97Gangrene (HP:0100758)2.11089141
98Cerebral aneurysm (HP:0004944)2.10649358
99Abnormality of T cell physiology (HP:0011840)2.10522072
100Disinhibition (HP:0000734)2.09249130
101Agammaglobulinemia (HP:0004432)2.09123563
102Fatigue (HP:0012378)2.08916028
103Glomerulonephritis (HP:0000099)2.08360817
104Prolonged bleeding time (HP:0003010)2.06089808
105Alveolar cell carcinoma (HP:0006519)2.05737997
106Myocardial infarction (HP:0001658)2.05281630
107Urticaria (HP:0001025)2.04068370
108Increased mean platelet volume (HP:0011877)2.03707321
109Vertebral compression fractures (HP:0002953)2.02893484
110Heterochromia iridis (HP:0001100)2.02525990
111Abnormality of oral frenula (HP:0000190)2.01556025
112Aortic dissection (HP:0002647)2.01072728
113Slow saccadic eye movements (HP:0000514)2.00390219
114Amyloidosis (HP:0011034)1.99612497
115Anorexia (HP:0002039)1.96737121
116Abnormality of the anterior horn cell (HP:0006802)1.96566087
117Degeneration of anterior horn cells (HP:0002398)1.96566087
118Keratitis (HP:0000491)1.95705188
119Severe combined immunodeficiency (HP:0004430)1.94927621
120Spontaneous hematomas (HP:0007420)1.93058569
121IgM deficiency (HP:0002850)1.93006964
122Bilateral sensorineural hearing impairment (HP:0008619)1.91758010
123Increased IgE level (HP:0003212)1.91752940
124Gastrointestinal inflammation (HP:0004386)1.91691266
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91567993
126Tetraparesis (HP:0002273)1.89709886
127Asymmetry of the thorax (HP:0001555)1.89589803
128Recurrent bronchitis (HP:0002837)1.89185667
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.89081254
130Inflammation of the large intestine (HP:0002037)1.87216130
131Skin ulcer (HP:0200042)1.87035895
132Aortic aneurysm (HP:0004942)1.83710347
133Insidious onset (HP:0003587)1.81154920
134Termporal pattern (HP:0011008)1.81154920
135Polycythemia (HP:0001901)1.79303118
136Loss of speech (HP:0002371)1.78444333
137Flat acetabular roof (HP:0003180)1.77719085
138Orthostatic hypotension (HP:0001278)1.77144322
139Amaurosis fugax (HP:0100576)1.75567810
140Mitral valve prolapse (HP:0001634)1.70920555
141Colitis (HP:0002583)1.70779753
142Dysostosis multiplex (HP:0000943)1.67517063
143Gastrointestinal stroma tumor (HP:0100723)1.63583791
144Papillary thyroid carcinoma (HP:0002895)1.63052985
145Abnormality of the common coagulation pathway (HP:0010990)1.62865295
146Aneurysm (HP:0002617)1.62109906
147Verrucae (HP:0200043)1.59206769
148Papilloma (HP:0012740)1.59206769
149Transitional cell carcinoma of the bladder (HP:0006740)1.58579210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.72088079
2IRAK43.32082040
3TXK3.19977719
4BMPR23.05831744
5SIK32.99130130
6* MAP3K142.85179949
7BLK2.82440232
8ERBB32.77112092
9MAP3K122.44567823
10JAK32.43158460
11CDK122.34667347
12IRAK32.31049909
13NEK92.23684471
14TBK12.15761761
15IKBKE2.14500986
16MST42.12503995
17ERN12.07566875
18MAP4K12.02342299
19TRIB32.02153001
20IKBKB2.00683507
21TYK21.98823022
22MAP2K31.93562739
23PBK1.85731184
24PIM21.83912938
25FGFR41.78955643
26KSR21.76741274
27PLK21.70166079
28JAK11.64346196
29SYK1.64227396
30SMG11.60941577
31PRPF4B1.60154410
32CLK11.56257131
33CHUK1.50015014
34MAP3K101.48090699
35TRPM71.44968842
36TEC1.43142755
37EPHB11.42468761
38FGR1.41786594
39KIT1.38862666
40CASK1.38088479
41PIM11.36650985
42PDGFRA1.36394489
43ZAP701.31748538
44MAP3K131.24867828
45BCR1.23331341
46SGK21.21219925
47KSR11.19070793
48TGFBR21.18975414
49ARAF1.18952523
50EIF2AK21.18265380
51YES11.17737285
52AKT31.13283028
53BTK1.12344247
54FGFR31.12096827
55MAP3K11.11216918
56EIF2AK11.09734481
57ZAK1.07866103
58MAP3K21.07341614
59BRD41.05348763
60LYN1.05076877
61RIPK11.03203399
62CSK1.00500664
63MAP3K31.00500330
64HCK1.00077249
65STK240.99766166
66MOS0.99686732
67LATS20.97497015
68TTN0.95521388
69PAK40.95394773
70MARK30.93972382
71MAP3K60.90757201
72LCK0.90494437
73ICK0.88633484
74STK40.88576328
75LRRK20.88506044
76SGK30.87144296
77TESK10.86036482
78MAP3K90.85562575
79PKN20.84221432
80FRK0.81768917
81PIK3CG0.79554957
82PTK60.79554250
83ALK0.78105211
84CDK40.76726130
85EEF2K0.76543766
86PRKCD0.76420482
87NEK60.76399170
88PLK30.74955607
89RET0.74192805
90ABL20.73956874
91CSF1R0.73404510
92MAP3K80.73290422
93PDPK10.73005671
94ADRBK20.71828957
95PDK10.71804335
96MATK0.71634371
97DAPK10.71259010
98PDGFRB0.70347747
99BRSK20.70268289
100NUAK10.69387454
101WNK10.69351810
102EIF2AK30.68122962
103TAOK20.67713953
104IRAK20.66902886
105RPS6KA60.66154139
106ITK0.64034873
107CDC42BPA0.63219249
108JAK20.62708895
109PRKCQ0.62359270
110FES0.61002974
111RPS6KC10.59292147
112RPS6KL10.59292147
113TSSK60.58784941
114MKNK10.52779062
115STK100.52231196
116BMPR1B0.51707056
117PLK40.50643126
118RPS6KB10.49789379
119IRAK10.49632813
120MAPKAPK20.49546814
121GRK70.47894845
122FYN0.47505645
123SCYL20.46831386
124MAP2K70.43534006
125SIK10.42751017
126MINK10.42431453
127GRK60.42186634
128MAP3K50.41351854
129NTRK10.41206556
130MELK0.40886989
131MAPK70.40277470
132ABL10.39664105
133RPS6KA20.37384181
134PAK20.36965650
135MAPK110.36716313
136ROCK20.36681831
137BRAF0.36144989
138RPS6KB20.36096987
139CDK90.35888734
140LATS10.35680276
141CAMKK20.35552168
142CDK60.34983015
143CAMKK10.34485410
144TAOK30.33596112
145MKNK20.33141506
146BMX0.32193171
147NME20.31181436
148RPS6KA40.31140605
149SGK4940.30031475
150SGK2230.30031475
151CCNB10.28647999
152EGFR0.26965245
153SRPK10.26519175
154RAF10.25639628
155SGK10.24044988

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.48122334
2Allograft rejection_Homo sapiens_hsa053303.26936847
3Leishmaniasis_Homo sapiens_hsa051402.85512159
4Type I diabetes mellitus_Homo sapiens_hsa049402.45858094
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38107999
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.36043118
7Legionellosis_Homo sapiens_hsa051342.28507912
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23708648
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.12294884
10Measles_Homo sapiens_hsa051622.09169100
11Rheumatoid arthritis_Homo sapiens_hsa053232.08194146
12Pertussis_Homo sapiens_hsa051331.98654830
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98591527
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96886105
15Staphylococcus aureus infection_Homo sapiens_hsa051501.96541981
16Autoimmune thyroid disease_Homo sapiens_hsa053201.95602047
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91221181
18Tuberculosis_Homo sapiens_hsa051521.89058643
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87891553
20Osteoclast differentiation_Homo sapiens_hsa043801.80533917
21Antigen processing and presentation_Homo sapiens_hsa046121.79516337
22Asthma_Homo sapiens_hsa053101.77091774
23Phagosome_Homo sapiens_hsa041451.76657620
24Influenza A_Homo sapiens_hsa051641.76545817
25Salmonella infection_Homo sapiens_hsa051321.75034071
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61000255
27Primary immunodeficiency_Homo sapiens_hsa053401.60050402
28Renal cell carcinoma_Homo sapiens_hsa052111.54156172
29Herpes simplex infection_Homo sapiens_hsa051681.46071717
30Shigellosis_Homo sapiens_hsa051311.43938218
31Malaria_Homo sapiens_hsa051441.42754429
32Chemokine signaling pathway_Homo sapiens_hsa040621.42325366
33Viral myocarditis_Homo sapiens_hsa054161.41510718
34African trypanosomiasis_Homo sapiens_hsa051431.39126734
35TNF signaling pathway_Homo sapiens_hsa046681.36148344
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36130287
37B cell receptor signaling pathway_Homo sapiens_hsa046621.33921324
38Toxoplasmosis_Homo sapiens_hsa051451.32107460
39Hematopoietic cell lineage_Homo sapiens_hsa046401.29665661
40Proteasome_Homo sapiens_hsa030501.24433132
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24370991
42Apoptosis_Homo sapiens_hsa042101.23289193
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21236816
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15648787
45VEGF signaling pathway_Homo sapiens_hsa043701.15542268
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.15148553
47Lysosome_Homo sapiens_hsa041421.09533804
48Hepatitis B_Homo sapiens_hsa051611.07530893
49Collecting duct acid secretion_Homo sapiens_hsa049661.06701221
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05344181
51Colorectal cancer_Homo sapiens_hsa052100.99453723
52Small cell lung cancer_Homo sapiens_hsa052220.98991260
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97295554
54Proteoglycans in cancer_Homo sapiens_hsa052050.96149073
55Focal adhesion_Homo sapiens_hsa045100.94252784
56T cell receptor signaling pathway_Homo sapiens_hsa046600.94067645
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.93290768
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92041374
59Bladder cancer_Homo sapiens_hsa052190.91385622
60Prostate cancer_Homo sapiens_hsa052150.90986985
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90551394
62ErbB signaling pathway_Homo sapiens_hsa040120.87335792
63mTOR signaling pathway_Homo sapiens_hsa041500.83089424
64Adherens junction_Homo sapiens_hsa045200.83070872
65Epstein-Barr virus infection_Homo sapiens_hsa051690.81634362
66Hepatitis C_Homo sapiens_hsa051600.81096293
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.80363233
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78125487
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77805706
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77533767
71MicroRNAs in cancer_Homo sapiens_hsa052060.75989618
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.75280829
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73472815
74Other glycan degradation_Homo sapiens_hsa005110.73246907
75Dorso-ventral axis formation_Homo sapiens_hsa043200.72975814
76GnRH signaling pathway_Homo sapiens_hsa049120.72928983
77Vibrio cholerae infection_Homo sapiens_hsa051100.72838583
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72259598
79Estrogen signaling pathway_Homo sapiens_hsa049150.70591272
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.70539953
81Inositol phosphate metabolism_Homo sapiens_hsa005620.70354516
82Choline metabolism in cancer_Homo sapiens_hsa052310.66467977
83Synaptic vesicle cycle_Homo sapiens_hsa047210.65254146
84Notch signaling pathway_Homo sapiens_hsa043300.63735815
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63256668
86Platelet activation_Homo sapiens_hsa046110.59778607
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58835740
88DNA replication_Homo sapiens_hsa030300.58109336
89Prolactin signaling pathway_Homo sapiens_hsa049170.55045501
90Acute myeloid leukemia_Homo sapiens_hsa052210.53024227
91Rap1 signaling pathway_Homo sapiens_hsa040150.52332143
92Insulin signaling pathway_Homo sapiens_hsa049100.52266963
93Base excision repair_Homo sapiens_hsa034100.51052932
94p53 signaling pathway_Homo sapiens_hsa041150.49805478
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49403776
96Pancreatic cancer_Homo sapiens_hsa052120.48519942
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44019404
98Viral carcinogenesis_Homo sapiens_hsa052030.43002145
99Amoebiasis_Homo sapiens_hsa051460.40392788
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38329265
101Prion diseases_Homo sapiens_hsa050200.37344135
102HIF-1 signaling pathway_Homo sapiens_hsa040660.37307657
103HTLV-I infection_Homo sapiens_hsa051660.35517796
104Thyroid cancer_Homo sapiens_hsa052160.34660395
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.33616938
106Homologous recombination_Homo sapiens_hsa034400.33491747
107Chronic myeloid leukemia_Homo sapiens_hsa052200.33251648
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30503046
109Olfactory transduction_Homo sapiens_hsa047400.29652586
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.28661319
111Mismatch repair_Homo sapiens_hsa034300.26337185
112FoxO signaling pathway_Homo sapiens_hsa040680.24277860
113Non-small cell lung cancer_Homo sapiens_hsa052230.24200933
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23211211
115MAPK signaling pathway_Homo sapiens_hsa040100.22019903
116Endometrial cancer_Homo sapiens_hsa052130.21451112
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21171816
118Long-term potentiation_Homo sapiens_hsa047200.20323833
119Melanoma_Homo sapiens_hsa052180.20105993
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20056543
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20029034
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19417386
123Glioma_Homo sapiens_hsa052140.18727419
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18295092
125Endocytosis_Homo sapiens_hsa041440.17622946

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