ACTR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.16546363
2layer formation in cerebral cortex (GO:0021819)4.96787945
3negative regulation of microtubule polymerization (GO:0031115)4.90984150
4pyrimidine nucleobase catabolic process (GO:0006208)4.89645819
5Golgi transport vesicle coating (GO:0048200)4.33281712
6COPI coating of Golgi vesicle (GO:0048205)4.33281712
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31329056
8locomotory exploration behavior (GO:0035641)4.27188868
9regulation of synaptic vesicle exocytosis (GO:2000300)4.24931533
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22484964
11glutamate secretion (GO:0014047)4.14541840
12regulation of synapse structural plasticity (GO:0051823)4.14469844
13nucleobase catabolic process (GO:0046113)4.03092163
14synaptic vesicle exocytosis (GO:0016079)4.00086208
15cell migration in hindbrain (GO:0021535)3.96844869
16vocalization behavior (GO:0071625)3.80253459
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.74805402
18dendrite morphogenesis (GO:0048813)3.70256968
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.69883833
20barbed-end actin filament capping (GO:0051016)3.67071852
21postsynaptic membrane organization (GO:0001941)3.57381287
22regulation of synaptic vesicle transport (GO:1902803)3.56417136
23activation of protein kinase A activity (GO:0034199)3.55658023
24protein retention in ER lumen (GO:0006621)3.54695049
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.54056397
26cerebellar Purkinje cell layer development (GO:0021680)3.53332008
27establishment of nucleus localization (GO:0040023)3.48218105
28clathrin coat assembly (GO:0048268)3.45836489
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42260567
30exploration behavior (GO:0035640)3.41936667
31sodium ion export (GO:0071436)3.41527425
32proline transport (GO:0015824)3.39040835
33regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.38470367
34protein localization to synapse (GO:0035418)3.34703981
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32994023
36cell communication by electrical coupling (GO:0010644)3.28574589
37positive regulation of synapse maturation (GO:0090129)3.28385565
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26498780
39establishment of mitochondrion localization (GO:0051654)3.21212766
40axon extension (GO:0048675)3.20257778
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19685134
42neuron recognition (GO:0008038)3.18841519
43positive regulation of axon extension (GO:0045773)3.18353001
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17759195
45regulation of NFAT protein import into nucleus (GO:0051532)3.11168060
46neurotransmitter secretion (GO:0007269)3.10533568
47dendritic spine morphogenesis (GO:0060997)3.08986208
48neuron cell-cell adhesion (GO:0007158)3.07748767
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06397711
50mitochondrion transport along microtubule (GO:0047497)3.06397711
51axon cargo transport (GO:0008088)3.04007808
52neuromuscular process controlling balance (GO:0050885)3.03133490
53regulation of glutamate receptor signaling pathway (GO:1900449)3.03108390
54organelle transport along microtubule (GO:0072384)3.01100098
55axonal fasciculation (GO:0007413)2.98999059
56neuron projection extension (GO:1990138)2.95730328
57protein insertion into membrane (GO:0051205)2.94333288
58regulation of neuronal synaptic plasticity (GO:0048168)2.93982165
59regulation of ARF protein signal transduction (GO:0032012)2.90657621
60cell-cell junction maintenance (GO:0045217)2.89472025
61negative regulation of axonogenesis (GO:0050771)2.89138644
62actin filament depolymerization (GO:0030042)2.86690715
63dendritic spine organization (GO:0097061)2.85224527
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82994676
65protein targeting to plasma membrane (GO:0072661)2.82789644
66cellular potassium ion homeostasis (GO:0030007)2.80403745
67regulation of axon extension (GO:0030516)2.77895078
68plasma membrane repair (GO:0001778)2.76670462
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75440097
70response to pheromone (GO:0019236)2.75300432
71nerve growth factor signaling pathway (GO:0038180)2.74166354
72regulation of early endosome to late endosome transport (GO:2000641)2.73806718
73protein localization to endosome (GO:0036010)2.73418121
74positive regulation of axonogenesis (GO:0050772)2.73165118
75vesicle transport along microtubule (GO:0047496)2.72102645
76negative regulation of organelle assembly (GO:1902116)2.72050166
77dopamine receptor signaling pathway (GO:0007212)2.70020466
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67347799
79detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.66389613
80detection of temperature stimulus involved in sensory perception (GO:0050961)2.66389613
81cerebral cortex neuron differentiation (GO:0021895)2.65484154
82negative regulation of cell size (GO:0045792)2.64246827
83amino acid import (GO:0043090)2.63661963
84regulation of extent of cell growth (GO:0061387)2.63649630
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62803984
86regulation of vesicle fusion (GO:0031338)2.62510372
87semaphorin-plexin signaling pathway (GO:0071526)2.62202364
88central nervous system projection neuron axonogenesis (GO:0021952)2.61992639
89response to auditory stimulus (GO:0010996)2.61374860
90regulation of axonogenesis (GO:0050770)2.60491589
91negative regulation of protein polymerization (GO:0032272)2.59799360
92regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58581898
93L-serine transport (GO:0015825)2.56800636
94positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55572316
95positive regulation of fibroblast migration (GO:0010763)2.55209004
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55108005
97cell communication involved in cardiac conduction (GO:0086065)2.54414488
98stress fiber assembly (GO:0043149)2.54328693
99regulation of dendritic spine morphogenesis (GO:0061001)2.53923570
100vesicle coating (GO:0006901)2.53771910
101regulation of synapse maturation (GO:0090128)2.53440936
102cellular response to nerve growth factor stimulus (GO:1990090)2.52908120
103response to nerve growth factor (GO:1990089)2.52908120
104* antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.52735180
105peptidyl-arginine omega-N-methylation (GO:0035247)2.51340734
106* antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.50563172
107* antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.50563172
108cerebellar granule cell differentiation (GO:0021707)2.50515096
109ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50037669
110mating behavior (GO:0007617)2.49834381
111positive regulation of vesicle fusion (GO:0031340)2.49521093
112cellular response to catecholamine stimulus (GO:0071870)2.48271649
113cellular response to monoamine stimulus (GO:0071868)2.48271649
114cell junction maintenance (GO:0034331)2.47697499
115negative regulation of axon extension (GO:0030517)2.47588333
116gamma-aminobutyric acid transport (GO:0015812)2.45917935
117axon extension involved in axon guidance (GO:0048846)2.45340327
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.45340327
119neuronal ion channel clustering (GO:0045161)2.45008412
120synaptic vesicle endocytosis (GO:0048488)2.44916989
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.43573377
122synapse organization (GO:0050808)2.43044861
123prepulse inhibition (GO:0060134)2.42749250
124glial cell proliferation (GO:0014009)2.42704662
125neuron projection morphogenesis (GO:0048812)2.41962498
126glycine transport (GO:0015816)2.41928698
127regulation of ARF GTPase activity (GO:0032312)2.41748943
128neurotransmitter-gated ion channel clustering (GO:0072578)2.41445706
129cell adhesion mediated by integrin (GO:0033627)2.39632817
130developmental cell growth (GO:0048588)2.39522843
131serine transport (GO:0032329)2.39014234
132transferrin transport (GO:0033572)2.38663313
133membrane assembly (GO:0071709)2.38368045
134protein maturation by protein folding (GO:0022417)2.37210828
135mitotic nuclear envelope reassembly (GO:0007084)2.36316624
136nuclear envelope reassembly (GO:0031468)2.36316624
137positive regulation of dendritic spine development (GO:0060999)2.35602380
138synapse assembly (GO:0007416)2.34606021
139positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.33447114
140regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.33447114
141adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.32989900
142neuronal action potential propagation (GO:0019227)2.32869896
143ganglion development (GO:0061548)2.31956824
144lens morphogenesis in camera-type eye (GO:0002089)2.31027104
145positive regulation of mitochondrial fission (GO:0090141)2.30115161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82435350
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69678751
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62878125
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34543654
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.33396998
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32963547
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32536842
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32536842
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30828590
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27187364
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21494997
12DROSHA_22980978_ChIP-Seq_HELA_Human2.21362412
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18926777
14REST_21632747_ChIP-Seq_MESCs_Mouse2.09655430
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06756741
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03919610
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.03763865
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02753007
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.01867586
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98566778
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.97803354
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97028461
23KDM2B_26808549_Chip-Seq_K562_Human1.96430927
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88160960
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.86429050
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86057662
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.85978114
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84051686
29* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83055657
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.80766238
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80669636
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80186698
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72395019
34* TET1_21451524_ChIP-Seq_MESCs_Mouse1.68673614
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.68056528
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67135196
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.62200059
38ZNF274_21170338_ChIP-Seq_K562_Hela1.59607807
39KDM2B_26808549_Chip-Seq_DND41_Human1.59347405
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59145294
41* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58960529
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54229916
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53778860
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53420025
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51327982
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.49842648
47* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49094929
48AR_21572438_ChIP-Seq_LNCaP_Human1.48975023
49ZNF263_19887448_ChIP-Seq_K562_Human1.48221923
50LXR_22292898_ChIP-Seq_THP-1_Human1.48128652
51RACK7_27058665_Chip-Seq_MCF-7_Human1.46042343
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43810292
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43597412
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42221128
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38244927
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.37685980
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35648804
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33203011
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30516262
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30485159
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29927968
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29270475
63SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.28915337
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28880794
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.28562968
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28012359
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25487580
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25426945
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25177429
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.24603914
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23533046
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22471514
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22184024
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22137086
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21786125
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.21582145
77SMC4_20622854_ChIP-Seq_HELA_Human1.21411681
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21272802
79CTCF_27219007_Chip-Seq_Bcells_Human1.20691659
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20123621
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19510588
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19385722
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19186559
84ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19130739
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18937435
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18711338
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16993854
88GBX2_23144817_ChIP-Seq_PC3_Human1.13304455
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12549984
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.10693736
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09764861
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09067210
93* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08486460
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08243474
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07844746
96* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07485718
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06998519
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06596864
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02327884
100AR_19668381_ChIP-Seq_PC3_Human1.01491940
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00578732
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00409460
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.99906361
104EP300_21415370_ChIP-Seq_HL-1_Mouse0.99204344
105CLOCK_20551151_ChIP-Seq_293T_Human0.98550932
106* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98296295
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97995606
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97483764
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97118298
110* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97040207
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96280838
112KLF4_19829295_ChIP-Seq_ESCs_Human0.95628928
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95540651
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.95350251
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.94582250
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.93951656
117CREB1_26743006_Chip-Seq_LNCaP_Human0.93506233
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93159234
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92265926
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92260659
121OCT4_19829295_ChIP-Seq_ESCs_Human0.92074335
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90196464
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89400622
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89115194
125TP53_22127205_ChIP-Seq_IMR90_Human0.87630770
126* P68_20966046_ChIP-Seq_HELA_Human0.87087204
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.86358338
128TP63_22573176_ChIP-Seq_HFKS_Human0.86088032
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.85824788
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.84567963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42975017
2MP0004270_analgesia3.66733466
3MP0004858_abnormal_nervous_system3.48979878
4MP0003635_abnormal_synaptic_transmissio3.22097133
5MP0003329_amyloid_beta_deposits3.06664369
6MP0001968_abnormal_touch/_nociception2.75750309
7MP0003880_abnormal_central_pattern2.65940476
8MP0002063_abnormal_learning/memory/cond2.63268896
9MP0002734_abnormal_mechanical_nocicepti2.40583489
10MP0005423_abnormal_somatic_nervous2.34301983
11MP0000778_abnormal_nervous_system2.29696625
12MP0002735_abnormal_chemical_nociception2.24638386
13MP0004811_abnormal_neuron_physiology2.18916486
14MP0002733_abnormal_thermal_nociception2.18595027
15MP0005623_abnormal_meninges_morphology2.17462521
16MP0002064_seizures2.16593839
17MP0003705_abnormal_hypodermis_morpholog2.15723889
18MP0002736_abnormal_nociception_after2.11197032
19MP0009745_abnormal_behavioral_response2.04257738
20MP0008260_abnormal_autophagy2.01544483
21MP0000751_myopathy2.00296709
22MP0005257_abnormal_intraocular_pressure1.96146282
23MP0008438_abnormal_cutaneous_collagen1.86283778
24MP0002572_abnormal_emotion/affect_behav1.82478390
25MP0001970_abnormal_pain_threshold1.82010476
26MP0002184_abnormal_innervation1.80075469
27MP0000955_abnormal_spinal_cord1.78508761
28MP0009046_muscle_twitch1.78145405
29MP0000750_abnormal_muscle_regeneration1.76765029
30MP0000569_abnormal_digit_pigmentation1.75866079
31MP0003566_abnormal_cell_adhesion1.71020346
32MP0005410_abnormal_fertilization1.62859241
33MP0002653_abnormal_ependyma_morphology1.62790833
34MP0004885_abnormal_endolymph1.62006807
35MP0006276_abnormal_autonomic_nervous1.61806556
36MP0005058_abnormal_lysosome_morphology1.59963066
37MP0000604_amyloidosis1.59810926
38MP0002909_abnormal_adrenal_gland1.59792433
39MP0009840_abnormal_foam_cell1.58444516
40MP0002272_abnormal_nervous_system1.56932937
41MP0009780_abnormal_chondrocyte_physiolo1.53208485
42MP0004233_abnormal_muscle_weight1.52529925
43MP0004510_myositis1.50848813
44MP0000013_abnormal_adipose_tissue1.47566439
45MP0002882_abnormal_neuron_morphology1.47559458
46MP0001486_abnormal_startle_reflex1.47116016
47MP0008569_lethality_at_weaning1.46352212
48MP0003634_abnormal_glial_cell1.44041182
49MP0001348_abnormal_lacrimal_gland1.42218456
50MP0000749_muscle_degeneration1.42160615
51MP0004272_abnormal_basement_membrane1.40985839
52MP0005386_behavior/neurological_phenoty1.39950341
53MP0004924_abnormal_behavior1.39950341
54MP0001440_abnormal_grooming_behavior1.39508135
55MP0002332_abnormal_exercise_endurance1.39302535
56MP0002067_abnormal_sensory_capabilities1.37509308
57MP0005275_abnormal_skin_tensile1.35727388
58MP0004130_abnormal_muscle_cell1.33659276
59MP0002557_abnormal_social/conspecific_i1.31920516
60MP0002152_abnormal_brain_morphology1.27598908
61MP0002066_abnormal_motor_capabilities/c1.26987052
62MP0008961_abnormal_basal_metabolism1.26357846
63MP0001299_abnormal_eye_distance/1.25131841
64MP0000920_abnormal_myelination1.24398861
65MP0010368_abnormal_lymphatic_system1.21889083
66MP0000534_abnormal_ureter_morphology1.16881438
67MP0001542_abnormal_bone_strength1.15816688
68MP0000747_muscle_weakness1.14519672
69MP0001958_emphysema1.11771320
70MP0003633_abnormal_nervous_system1.08814100
71MP0003191_abnormal_cellular_cholesterol1.07306364
72MP0002822_catalepsy1.06400183
73MP0003631_nervous_system_phenotype1.04863401
74MP0002877_abnormal_melanocyte_morpholog1.00813731
75MP0003861_abnormal_nervous_system1.00323377
76MP0003091_abnormal_cell_migration1.00026445
77MP0002837_dystrophic_cardiac_calcinosis0.98672989
78MP0001529_abnormal_vocalization0.98404806
79MP0000767_abnormal_smooth_muscle0.97702502
80MP0000537_abnormal_urethra_morphology0.96965362
81MP0003632_abnormal_nervous_system0.95978590
82MP0010030_abnormal_orbit_morphology0.94817139
83MP0008874_decreased_physiological_sensi0.94231027
84MP0005187_abnormal_penis_morphology0.93017841
85MP0002234_abnormal_pharynx_morphology0.92227694
86MP0000343_altered_response_to0.91302001
87MP0005451_abnormal_body_composition0.91140519
88MP0005409_darkened_coat_color0.89568652
89MP0001849_ear_inflammation0.88884719
90MP0000003_abnormal_adipose_tissue0.86547918
91MP0002896_abnormal_bone_mineralization0.85945401
92MP0003075_altered_response_to0.83489600
93MP0003300_gastrointestinal_ulcer0.80242367
94MP0000759_abnormal_skeletal_muscle0.79823231
95MP0003123_paternal_imprinting0.79473788
96MP0002229_neurodegeneration0.79062827
97MP0002106_abnormal_muscle_physiology0.77869792
98MP0003303_peritoneal_inflammation0.77859606
99MP0003122_maternal_imprinting0.77248364
100MP0010234_abnormal_vibrissa_follicle0.77165047
101MP0003879_abnormal_hair_cell0.76989269
102MP0004087_abnormal_muscle_fiber0.76169626
103MP0002972_abnormal_cardiac_muscle0.75635739
104MP0002069_abnormal_eating/drinking_beha0.75159404
105MP0003690_abnormal_glial_cell0.74013415
106MP0001177_atelectasis0.72091057
107MP0001270_distended_abdomen0.71461068
108MP0001984_abnormal_olfaction0.71433566
109MP0004085_abnormal_heartbeat0.70803180
110MP0005620_abnormal_muscle_contractility0.70167117
111MP0005076_abnormal_cell_differentiation0.70146537
112MP0005499_abnormal_olfactory_system0.70074674
113MP0005394_taste/olfaction_phenotype0.70074674
114MP0001501_abnormal_sleep_pattern0.69857123
115MP0002089_abnormal_postnatal_growth/wei0.69853484
116MP0002090_abnormal_vision0.69591722
117MP0001502_abnormal_circadian_rhythm0.69504806
118MP0000733_abnormal_muscle_development0.68704109
119MP0002752_abnormal_somatic_nervous0.67877052
120MP0002269_muscular_atrophy0.67075488
121MP0003172_abnormal_lysosome_physiology0.66617603
122MP0003283_abnormal_digestive_organ0.65987827
123MP0001943_abnormal_respiration0.63433359
124MP0001905_abnormal_dopamine_level0.62926630
125MP0003279_aneurysm0.62830602
126MP0003221_abnormal_cardiomyocyte_apopto0.61851051
127MP0003385_abnormal_body_wall0.61343905
128MP0003137_abnormal_impulse_conducting0.61028230

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.41324100
2Supranuclear gaze palsy (HP:0000605)3.90634018
3Ankle clonus (HP:0011448)3.52079268
4Termporal pattern (HP:0011008)3.44541643
5Insidious onset (HP:0003587)3.44541643
6Neurofibrillary tangles (HP:0002185)3.20406990
7Abnormality of the lower motor neuron (HP:0002366)3.20011829
8Cerebral inclusion bodies (HP:0100314)3.19793356
9Amyotrophic lateral sclerosis (HP:0007354)3.16514533
10Visual hallucinations (HP:0002367)3.03397584
11Distal lower limb amyotrophy (HP:0008944)3.02835402
12Urinary urgency (HP:0000012)3.01124922
13Insomnia (HP:0100785)3.00564634
14Focal seizures (HP:0007359)2.99702957
15Pheochromocytoma (HP:0002666)2.94658418
16Hyperacusis (HP:0010780)2.89005628
17Spinal rigidity (HP:0003306)2.78412507
18Action tremor (HP:0002345)2.76564619
19Mutism (HP:0002300)2.74171592
20Abnormality of the corticospinal tract (HP:0002492)2.60213125
21Megalencephaly (HP:0001355)2.59691449
22Neuroendocrine neoplasm (HP:0100634)2.52227728
23Limb dystonia (HP:0002451)2.52163295
24Increased connective tissue (HP:0009025)2.47515875
25Shallow orbits (HP:0000586)2.41525267
26Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40807575
27Hypoplasia of the brainstem (HP:0002365)2.40807575
28Pointed chin (HP:0000307)2.40640396
29Apathy (HP:0000741)2.39863970
30Spastic gait (HP:0002064)2.39842678
31Peripheral hypomyelination (HP:0007182)2.39838930
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.38362654
33Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.36971604
34Depression (HP:0000716)2.36794554
35Distal upper limb amyotrophy (HP:0007149)2.36696303
36Upper limb amyotrophy (HP:0009129)2.36696303
37Papilledema (HP:0001085)2.36062798
38Torticollis (HP:0000473)2.35874467
39Shoulder girdle muscle weakness (HP:0003547)2.35009932
40Focal motor seizures (HP:0011153)2.33489737
41Vertebral compression fractures (HP:0002953)2.33411474
42Neoplasm of the peripheral nervous system (HP:0100007)2.33398955
43Atrophic scars (HP:0001075)2.31887125
44Overriding aorta (HP:0002623)2.25347569
45Abnormal eating behavior (HP:0100738)2.24589313
46Rapidly progressive (HP:0003678)2.24487731
47Diminished motivation (HP:0000745)2.24072267
48Lower limb muscle weakness (HP:0007340)2.24056307
49Type 1 muscle fiber predominance (HP:0003803)2.22991385
50Bladder diverticulum (HP:0000015)2.22857355
51Urinary bladder sphincter dysfunction (HP:0002839)2.20861776
52Impaired vibration sensation in the lower limbs (HP:0002166)2.20458048
53Progressive cerebellar ataxia (HP:0002073)2.18845780
54Limb-girdle muscle weakness (HP:0003325)2.18463381
55Difficulty running (HP:0009046)2.17832353
56Hypercortisolism (HP:0001578)2.16745732
57Polyphagia (HP:0002591)2.16700265
58Failure to thrive in infancy (HP:0001531)2.15438243
59Elfin facies (HP:0004428)2.14345456
60Bowel diverticulosis (HP:0005222)2.14137349
61Hand muscle atrophy (HP:0009130)2.12475803
62Upper limb muscle weakness (HP:0003484)2.11020994
63Distal lower limb muscle weakness (HP:0009053)2.10728856
64Abnormality of skeletal muscle fiber size (HP:0012084)2.10319568
65Hammertoe (HP:0001765)2.10077715
66Truncal ataxia (HP:0002078)2.09284155
67Mildly elevated creatine phosphokinase (HP:0008180)2.08912537
68Lissencephaly (HP:0001339)2.07969940
69Buphthalmos (HP:0000557)2.07814702
70Scapular winging (HP:0003691)2.06851924
71Hypoventilation (HP:0002791)2.06518440
72Cerebral aneurysm (HP:0004944)2.05119808
73Long palpebral fissure (HP:0000637)2.03457722
74Lower limb amyotrophy (HP:0007210)2.02382604
75Ankle contracture (HP:0006466)2.02228540
76Poor eye contact (HP:0000817)2.01205413
77Abnormal social behavior (HP:0012433)2.00909505
78Impaired social interactions (HP:0000735)2.00909505
79Increased variability in muscle fiber diameter (HP:0003557)1.99871461
80Onion bulb formation (HP:0003383)1.98707996
81Turricephaly (HP:0000262)1.97020234
82Focal dystonia (HP:0004373)1.96840963
83Premature rupture of membranes (HP:0001788)1.96501051
84Neoplasm of the heart (HP:0100544)1.95905030
85Akinesia (HP:0002304)1.95269712
86Back pain (HP:0003418)1.94934712
87Abnormal neuron morphology (HP:0012757)1.94717253
88Abnormality of the motor neurons (HP:0002450)1.94717253
89Cholecystitis (HP:0001082)1.94616286
90Abnormal gallbladder physiology (HP:0012438)1.94616286
91Epileptic encephalopathy (HP:0200134)1.93963222
92Achilles tendon contracture (HP:0001771)1.92896257
93Protrusio acetabuli (HP:0003179)1.92089422
94Renal duplication (HP:0000075)1.91506928
95Hyporeflexia of lower limbs (HP:0002600)1.91370993
96Abnormality of the Achilles tendon (HP:0005109)1.91097234
97Craniofacial dystonia (HP:0012179)1.90297122
98Pachygyria (HP:0001302)1.89552207
99Neuronal loss in central nervous system (HP:0002529)1.88425455
100Mitral regurgitation (HP:0001653)1.87797197
101Wrist flexion contracture (HP:0001239)1.87234051
102Difficulty climbing stairs (HP:0003551)1.86577103
103Renovascular hypertension (HP:0100817)1.85992325
104Generalized hypotonia (HP:0001290)1.85943575
105Wormian bones (HP:0002645)1.85723039
106Amblyopia (HP:0000646)1.84835841
107Steppage gait (HP:0003376)1.83640070
108Slender build (HP:0001533)1.83461488
109Abnormality of the hip-girdle musculature (HP:0001445)1.82750802
110Abnormality of the musculature of the pelvis (HP:0001469)1.82750802
111Aqueductal stenosis (HP:0002410)1.81009475
112Pelvic girdle muscle weakness (HP:0003749)1.80819948
113Foot dorsiflexor weakness (HP:0009027)1.80174388
114Postural instability (HP:0002172)1.80063398
115Upper motor neuron abnormality (HP:0002127)1.80006673
116Myopathic facies (HP:0002058)1.79481249
117Distal sensory impairment (HP:0002936)1.79144872
118Ulnar claw (HP:0001178)1.78547349
119Slow progression (HP:0003677)1.78219104
120Short nail (HP:0001799)1.76231178
121Clonus (HP:0002169)1.75064984
122Flat cornea (HP:0007720)1.75005122
123Cortical dysplasia (HP:0002539)1.74580053
124Atonic seizures (HP:0010819)1.74418540
125Limb-girdle muscle atrophy (HP:0003797)1.73163353
126Genu recurvatum (HP:0002816)1.72403467
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72353311
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72163130
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.72163130
130Abnormality of the foot musculature (HP:0001436)1.70683716
131Decreased motor nerve conduction velocity (HP:0003431)1.70124876
132Scanning speech (HP:0002168)1.69776254
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.69536133
134Abnormality of liposaccharide metabolism (HP:0010968)1.69521227
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.69521227
136Abnormality of glycolipid metabolism (HP:0010969)1.69521227
137Abnormality of dentin (HP:0010299)1.69405737
138Long toe (HP:0010511)1.68739646
139Open mouth (HP:0000194)1.68113998
140Fetal akinesia sequence (HP:0001989)1.66009547
141Abnormality of pain sensation (HP:0010832)1.63480082
142Impaired pain sensation (HP:0007328)1.63480082
143Spastic diplegia (HP:0001264)1.63237499
144Axonal loss (HP:0003447)1.61744017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.33392619
2MAP3K93.39105910
3TRIB32.96985999
4LIMK12.60233567
5PAK62.41930594
6MINK12.41766446
7TESK12.37018722
8KSR22.31978337
9PRKD32.24449474
10ICK2.04768757
11LATS21.94238163
12MAP3K41.92708177
13NTRK21.89588808
14TYRO31.78301033
15LMTK21.74651639
16EEF2K1.73811068
17NTRK11.69495431
18NTRK31.67781839
19PRPF4B1.66012162
20PKN21.65790437
21MAP3K111.62759207
22PHKG11.59794636
23PHKG21.59794636
24CAMKK11.57110023
25RET1.53782028
26PIM21.50028107
27DAPK21.44297706
28KSR11.43799307
29NEK11.33179638
30EPHA31.32526607
31PDK31.31988128
32PDK41.31988128
33IRAK31.29711585
34MAP3K61.28534826
35UHMK11.27861584
36DYRK21.27450861
37SCYL21.27126033
38DYRK1B1.26242817
39PDGFRA1.25874566
40CDK51.25810207
41TAOK11.23896040
42MAP2K41.19883743
43CDK141.17931025
44MAPK131.17473983
45CSNK1A1L1.15252267
46CDK181.14792728
47TTN1.14743490
48CDK151.13997527
49PAK31.13159091
50TESK21.10776386
51EPHA41.07476714
52FGFR21.06926840
53MAP3K21.02981276
54MAP2K71.01598465
55PAK41.00576691
56TAOK20.99091494
57CDK11A0.97904613
58ARAF0.97243461
59ALK0.94176525
60RIPK10.93960390
61STK380.90607715
62DDR20.90463718
63SIK30.89043458
64PRKCH0.88957373
65SMG10.84735417
66MOS0.84176384
67PRKD20.83498942
68CSNK1G20.79543329
69DMPK0.78665497
70PLK20.78556967
71SIK20.78438691
72CAMK2G0.78298714
73MARK20.77786152
74EPHB20.77717508
75ERBB30.77070067
76ROCK20.76562773
77CDK190.74761557
78RPS6KA20.74654028
79SIK10.74648034
80PTK2B0.74260628
81MAP2K10.74197319
82CAMK2B0.73878593
83CASK0.72961597
84WNK10.72442083
85FER0.71532445
86CCNB10.69644730
87SGK4940.66115985
88SGK2230.66115985
89CAMK1G0.65751051
90PTK20.65222549
91ROCK10.63849249
92ERN10.63001262
93MAP3K120.60421728
94GRK50.60129688
95PRKCG0.59541281
96ABL20.59036248
97CAMK1D0.57576716
98BCR0.57340582
99EPHB10.56506685
100ILK0.56312139
101DAPK10.56205137
102CAMK40.55712110
103BMX0.54360057
104CSNK1G10.53643575
105PTK60.53138550
106CSNK1G30.53028505
107PRKCZ0.52494114
108BCKDK0.52194310
109NME20.50782173
110MAP3K50.50722558
111BRAF0.48168698
112CAMKK20.47890791
113CDC42BPA0.47835529
114AURKA0.47572828
115PDPK10.47282080
116FYN0.44928522
117PAK20.44895983
118PAK10.44867951
119FGFR10.44762786
120DAPK30.44328716
121LRRK20.44085241
122TIE10.43921506
123BRSK10.43529133
124MAPK120.42507642
125PDGFRB0.42169348
126CAMK2D0.41176003
127PDK10.40361092
128STK390.40100131
129PRKD10.39896602
130DYRK1A0.39227803
131RAF10.39146623
132CAMK10.39117909
133STK110.39044953
134WNK40.38983298
135PNCK0.38979129
136MAPKAPK30.38804643
137AKT20.38572773
138MYLK0.36890766

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.78130550
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33991923
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07618619
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78123191
5Dopaminergic synapse_Homo sapiens_hsa047281.77454643
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73968950
7Axon guidance_Homo sapiens_hsa043601.70085895
8Olfactory transduction_Homo sapiens_hsa047401.68889170
9Circadian entrainment_Homo sapiens_hsa047131.67607767
10Long-term potentiation_Homo sapiens_hsa047201.64835174
11Gap junction_Homo sapiens_hsa045401.62621377
12GABAergic synapse_Homo sapiens_hsa047271.60429391
13Cholinergic synapse_Homo sapiens_hsa047251.59146209
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58340506
15Glioma_Homo sapiens_hsa052141.57262890
16Glutamatergic synapse_Homo sapiens_hsa047241.46813692
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39147422
18Gastric acid secretion_Homo sapiens_hsa049711.38523765
19Morphine addiction_Homo sapiens_hsa050321.36304543
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34504829
21Estrogen signaling pathway_Homo sapiens_hsa049151.33583264
22Nicotine addiction_Homo sapiens_hsa050331.32550742
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30896437
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.30057088
25VEGF signaling pathway_Homo sapiens_hsa043701.30018352
26GnRH signaling pathway_Homo sapiens_hsa049121.29973975
27Endometrial cancer_Homo sapiens_hsa052131.28715183
28Renal cell carcinoma_Homo sapiens_hsa052111.27371565
29Oxytocin signaling pathway_Homo sapiens_hsa049211.26845964
30Amphetamine addiction_Homo sapiens_hsa050311.24738415
31Endocytosis_Homo sapiens_hsa041441.23543877
32ErbB signaling pathway_Homo sapiens_hsa040121.23471690
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22465717
34Renin secretion_Homo sapiens_hsa049241.20336422
35Cocaine addiction_Homo sapiens_hsa050301.18170498
36Insulin secretion_Homo sapiens_hsa049111.16574547
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16306589
38Oocyte meiosis_Homo sapiens_hsa041141.15945793
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.15699943
40Salivary secretion_Homo sapiens_hsa049701.15640123
41Colorectal cancer_Homo sapiens_hsa052101.12380492
42Dorso-ventral axis formation_Homo sapiens_hsa043201.11613720
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10224753
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09712946
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08658073
46Long-term depression_Homo sapiens_hsa047301.07577027
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06614510
48Lysosome_Homo sapiens_hsa041421.04115185
49mTOR signaling pathway_Homo sapiens_hsa041501.01195177
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01050099
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00493061
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99453387
53Dilated cardiomyopathy_Homo sapiens_hsa054140.97898579
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.97867845
55Type II diabetes mellitus_Homo sapiens_hsa049300.97833163
56Non-small cell lung cancer_Homo sapiens_hsa052230.96263863
57Vibrio cholerae infection_Homo sapiens_hsa051100.94643645
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92356903
59Chronic myeloid leukemia_Homo sapiens_hsa052200.91549437
60Insulin signaling pathway_Homo sapiens_hsa049100.90682514
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90648273
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90037795
63Serotonergic synapse_Homo sapiens_hsa047260.89090264
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87892558
65Pancreatic cancer_Homo sapiens_hsa052120.87841866
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87225447
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.86920750
68Melanogenesis_Homo sapiens_hsa049160.86265950
69Fructose and mannose metabolism_Homo sapiens_hsa000510.84825940
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.83829880
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83753807
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80702046
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80332961
74Notch signaling pathway_Homo sapiens_hsa043300.79841030
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79022196
76Focal adhesion_Homo sapiens_hsa045100.78986643
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78688396
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77693613
79Tight junction_Homo sapiens_hsa045300.75843203
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75613278
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75159477
82Galactose metabolism_Homo sapiens_hsa000520.74775720
83cAMP signaling pathway_Homo sapiens_hsa040240.74432748
84Proteoglycans in cancer_Homo sapiens_hsa052050.74206086
85Viral myocarditis_Homo sapiens_hsa054160.73693082
86AMPK signaling pathway_Homo sapiens_hsa041520.73389767
87Cardiac muscle contraction_Homo sapiens_hsa042600.72404549
88ECM-receptor interaction_Homo sapiens_hsa045120.72003157
89Pentose phosphate pathway_Homo sapiens_hsa000300.71886518
90Choline metabolism in cancer_Homo sapiens_hsa052310.71502673
91Hippo signaling pathway_Homo sapiens_hsa043900.71358706
92Collecting duct acid secretion_Homo sapiens_hsa049660.71179376
93Steroid biosynthesis_Homo sapiens_hsa001000.71052483
94Rap1 signaling pathway_Homo sapiens_hsa040150.70935712
95Nitrogen metabolism_Homo sapiens_hsa009100.70844119
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70505722
97MAPK signaling pathway_Homo sapiens_hsa040100.69809211
98Alcoholism_Homo sapiens_hsa050340.67549557
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67439921
100Carbon metabolism_Homo sapiens_hsa012000.67356332
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66959230
102Adherens junction_Homo sapiens_hsa045200.66895964
103Calcium signaling pathway_Homo sapiens_hsa040200.66172676
104Fatty acid biosynthesis_Homo sapiens_hsa000610.65982502
105Amoebiasis_Homo sapiens_hsa051460.65789161
106Other glycan degradation_Homo sapiens_hsa005110.65608845
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65081032
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64630859
109Salmonella infection_Homo sapiens_hsa051320.63519043
110Glucagon signaling pathway_Homo sapiens_hsa049220.63162611
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63008590
112Ras signaling pathway_Homo sapiens_hsa040140.62640391
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.59594996
114Phagosome_Homo sapiens_hsa041450.59437643
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59412848
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58333569
117Shigellosis_Homo sapiens_hsa051310.57875196
118Prion diseases_Homo sapiens_hsa050200.56455131
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55319336
120Bladder cancer_Homo sapiens_hsa052190.54254729
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53754162
122Taste transduction_Homo sapiens_hsa047420.52761752
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52421475
124Inositol phosphate metabolism_Homo sapiens_hsa005620.51754591
125Prolactin signaling pathway_Homo sapiens_hsa049170.50689483

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