ACTR10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.82684159
2neuron cell-cell adhesion (GO:0007158)5.69293273
3presynaptic membrane organization (GO:0097090)5.41166491
4postsynaptic membrane organization (GO:0001941)4.48856891
5negative regulation of synaptic transmission, GABAergic (GO:0032229)4.28032075
6protein localization to synapse (GO:0035418)4.26059981
7neurotransmitter-gated ion channel clustering (GO:0072578)4.25230613
8vocalization behavior (GO:0071625)4.24531152
9synaptic vesicle exocytosis (GO:0016079)4.22936337
10pyrimidine nucleobase catabolic process (GO:0006208)4.17609455
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13888644
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03807366
13neuronal action potential propagation (GO:0019227)3.86090556
14regulation of synaptic vesicle exocytosis (GO:2000300)3.77727046
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77704635
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.72676305
17ATP hydrolysis coupled proton transport (GO:0015991)3.72676305
18transferrin transport (GO:0033572)3.64470299
19nucleobase catabolic process (GO:0046113)3.64308988
20chaperone-mediated protein transport (GO:0072321)3.63927129
21behavioral response to nicotine (GO:0035095)3.63556798
22positive regulation of synapse assembly (GO:0051965)3.63395423
23startle response (GO:0001964)3.62238470
24neuron-neuron synaptic transmission (GO:0007270)3.62181096
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60956567
26protein neddylation (GO:0045116)3.58656254
27platelet dense granule organization (GO:0060155)3.56605578
28gamma-aminobutyric acid signaling pathway (GO:0007214)3.56338328
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.51375945
30negative regulation of response to food (GO:0032096)3.47161592
31negative regulation of appetite (GO:0032099)3.47161592
32protein localization to cilium (GO:0061512)3.42659579
33glutamate secretion (GO:0014047)3.40824088
34trivalent inorganic cation transport (GO:0072512)3.38757023
35ferric iron transport (GO:0015682)3.38757023
36positive regulation of mitochondrial fission (GO:0090141)3.37269552
37synaptic transmission, glutamatergic (GO:0035249)3.37069747
38negative regulation of dendrite morphogenesis (GO:0050774)3.36698330
39regulation of glutamate receptor signaling pathway (GO:1900449)3.36235879
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.33176653
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31794183
42negative regulation of neurotransmitter transport (GO:0051589)3.31014590
43cellular ketone body metabolic process (GO:0046950)3.29690333
44neuron recognition (GO:0008038)3.25806520
45glutamate receptor signaling pathway (GO:0007215)3.25293291
46ATP synthesis coupled proton transport (GO:0015986)3.24114992
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24114992
48regulation of cilium movement (GO:0003352)3.21269427
49regulation of synaptic vesicle transport (GO:1902803)3.21027218
50regulation of glutamate secretion (GO:0014048)3.20374022
51regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17643411
52long-term synaptic potentiation (GO:0060291)3.16902278
53mechanosensory behavior (GO:0007638)3.16856846
54regulation of feeding behavior (GO:0060259)3.15609299
55sequestering of actin monomers (GO:0042989)3.12759143
56dendrite development (GO:0016358)3.12630057
57protein complex biogenesis (GO:0070271)3.12077660
58cerebellar granule cell differentiation (GO:0021707)3.10824930
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10091558
60gamma-aminobutyric acid transport (GO:0015812)3.09334426
61positive regulation of protein homodimerization activity (GO:0090073)3.07205140
62long-chain fatty acid biosynthetic process (GO:0042759)3.06040167
63cullin deneddylation (GO:0010388)3.04020114
64inositol phosphate catabolic process (GO:0071545)3.01164932
65positive regulation of amino acid transport (GO:0051957)3.01054536
66neurotransmitter uptake (GO:0001504)2.98598621
67ketone body metabolic process (GO:1902224)2.98516609
68positive regulation of actin filament depolymerization (GO:0030836)2.98308348
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95924564
70behavioral response to cocaine (GO:0048148)2.95857204
71epithelial cilium movement (GO:0003351)2.95045717
72water-soluble vitamin biosynthetic process (GO:0042364)2.95021002
73response to histamine (GO:0034776)2.94864834
74glycosphingolipid biosynthetic process (GO:0006688)2.93553192
75female mating behavior (GO:0060180)2.92826462
76neurotransmitter secretion (GO:0007269)2.92008279
77regulation of synapse assembly (GO:0051963)2.91098293
78proteasome assembly (GO:0043248)2.89948773
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89891416
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.89891416
81NADH dehydrogenase complex assembly (GO:0010257)2.89891416
82synapse assembly (GO:0007416)2.87459905
83regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85010051
84cilium morphogenesis (GO:0060271)2.84174294
85response to cocaine (GO:0042220)2.83436411
86positive regulation of membrane potential (GO:0045838)2.83077043
87respiratory electron transport chain (GO:0022904)2.82914939
88regulation of synaptic transmission, glutamatergic (GO:0051966)2.82618379
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81414617
90response to pheromone (GO:0019236)2.80524532
91retinal ganglion cell axon guidance (GO:0031290)2.78629735
92transmission of nerve impulse (GO:0019226)2.78096814
93regulation of synaptic transmission, GABAergic (GO:0032228)2.77828090
94electron transport chain (GO:0022900)2.77291549
95phosphorylated carbohydrate dephosphorylation (GO:0046838)2.77182492
96inositol phosphate dephosphorylation (GO:0046855)2.77182492
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77061386
98viral protein processing (GO:0019082)2.75919421
99regulation of postsynaptic membrane potential (GO:0060078)2.75572121
100calcium ion-dependent exocytosis (GO:0017156)2.75506557
101nonmotile primary cilium assembly (GO:0035058)2.75252134
102phagosome maturation (GO:0090382)2.74498117
103regulation of protein kinase A signaling (GO:0010738)2.73489557
104axon ensheathment in central nervous system (GO:0032291)2.72161742
105central nervous system myelination (GO:0022010)2.72161742
106dopamine transport (GO:0015872)2.70495505
107membrane assembly (GO:0071709)2.70468667
108cerebral cortex radially oriented cell migration (GO:0021799)2.70363739
109anterograde synaptic vesicle transport (GO:0048490)2.70148074
110regulation of neurotransmitter secretion (GO:0046928)2.68709529
111positive regulation of neurotransmitter transport (GO:0051590)2.68066169
112protein-cofactor linkage (GO:0018065)2.68018834
113auditory behavior (GO:0031223)2.67582620
114regulation of respiratory system process (GO:0044065)2.67055198
115regulation of hexokinase activity (GO:1903299)2.66785143
116regulation of glucokinase activity (GO:0033131)2.66785143
117protein polyglutamylation (GO:0018095)2.66616072
118regulation of female receptivity (GO:0045924)2.66296812
119mitochondrial respiratory chain complex assembly (GO:0033108)2.65983776
120protein deneddylation (GO:0000338)2.65705634
121negative regulation of dendrite development (GO:2000171)2.65051369
122neurotransmitter transport (GO:0006836)2.63857619
123axonal fasciculation (GO:0007413)2.63462097
124preassembly of GPI anchor in ER membrane (GO:0016254)2.63254838
125dendritic spine morphogenesis (GO:0060997)2.63211487
126regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.63196481
127intraciliary transport (GO:0042073)2.62155170
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60474887
129respiratory chain complex IV assembly (GO:0008535)2.60107398
130positive regulation of neurotransmitter secretion (GO:0001956)2.59868417
131negative regulation of heart rate (GO:0010459)2.59273349
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.58450190
133negative regulation of neurotransmitter secretion (GO:0046929)2.58017150
134GPI anchor metabolic process (GO:0006505)2.57028157
135fatty acid elongation (GO:0030497)2.56937958
136neuronal action potential (GO:0019228)2.56255977
137negative regulation of membrane potential (GO:0045837)2.56242364
138peptidyl-cysteine modification (GO:0018198)2.54586193
139regulation of acyl-CoA biosynthetic process (GO:0050812)2.52769536
140mannosylation (GO:0097502)2.51702447
141positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51536002
142regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.50011397
143detection of light stimulus involved in visual perception (GO:0050908)2.49052314
144detection of light stimulus involved in sensory perception (GO:0050962)2.49052314
145neurofilament cytoskeleton organization (GO:0060052)2.48801182
146aldehyde catabolic process (GO:0046185)2.48800421
147regulation of appetite (GO:0032098)2.48201067
148ribonucleoprotein complex disassembly (GO:0032988)2.45929296
149negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.45456517
150synaptic transmission, cholinergic (GO:0007271)2.45160310
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.44799769
152C-terminal protein lipidation (GO:0006501)2.44399462
153reflex (GO:0060004)2.44073111
154behavioral response to ethanol (GO:0048149)2.42095334
155organelle disassembly (GO:1903008)2.41653325
156cilium organization (GO:0044782)2.41161389
157C-terminal protein amino acid modification (GO:0018410)2.41112695
158regulation of action potential (GO:0098900)2.40960177
159regulation of microtubule-based movement (GO:0060632)2.40300686
160glycerophospholipid catabolic process (GO:0046475)2.40201660
161neural tube formation (GO:0001841)2.40132275
162cilium assembly (GO:0042384)2.38844270
163retinal cone cell development (GO:0046549)2.37863064
164regulation of cofactor metabolic process (GO:0051193)2.36131324
165regulation of coenzyme metabolic process (GO:0051196)2.36131324
166proton transport (GO:0015992)2.35939278
167hydrogen transport (GO:0006818)2.34301821
168glycolipid biosynthetic process (GO:0009247)2.32612231
169synaptic vesicle maturation (GO:0016188)2.32521481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.60014142
2GBX2_23144817_ChIP-Seq_PC3_Human4.42188590
3TAF15_26573619_Chip-Seq_HEK293_Human3.02856313
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86860595
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65718742
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52693050
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36743953
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32100386
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31016017
10VDR_22108803_ChIP-Seq_LS180_Human2.30497126
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30077521
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26182053
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22728198
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.21868852
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20321885
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14116429
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.10997453
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09327820
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.03380041
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.03051036
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02352655
22P300_19829295_ChIP-Seq_ESCs_Human2.00937484
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00935949
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00580628
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98628090
26FUS_26573619_Chip-Seq_HEK293_Human1.98533033
27REST_21632747_ChIP-Seq_MESCs_Mouse1.94112619
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91615863
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85931685
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85931685
31RNF2_27304074_Chip-Seq_NSC_Mouse1.75819802
32SMAD4_21799915_ChIP-Seq_A2780_Human1.73462749
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71777009
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70852057
35IGF1R_20145208_ChIP-Seq_DFB_Human1.66748324
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64995868
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64832736
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.64285972
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63771564
40ER_23166858_ChIP-Seq_MCF-7_Human1.62566811
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62522879
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60722808
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.58563893
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58527588
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57482167
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.57381547
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.57361891
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57327117
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53374570
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.52783092
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.52242199
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52202488
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.51837697
54ELK1_19687146_ChIP-ChIP_HELA_Human1.43789110
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43512665
56TP53_22573176_ChIP-Seq_HFKS_Human1.42961800
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42935134
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42680240
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.41345838
60CBP_20019798_ChIP-Seq_JUKART_Human1.41323010
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41323010
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38479903
63AR_21572438_ChIP-Seq_LNCaP_Human1.36739299
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.36190382
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35824223
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35602274
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.32840106
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32126561
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32015751
70BCAT_22108803_ChIP-Seq_LS180_Human1.30245351
71AR_25329375_ChIP-Seq_VCAP_Human1.29318844
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26271031
73P53_22387025_ChIP-Seq_ESCs_Mouse1.25806012
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25654524
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.24667015
76ZNF274_21170338_ChIP-Seq_K562_Hela1.24389152
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.23867145
78NANOG_19829295_ChIP-Seq_ESCs_Human1.23848568
79SOX2_19829295_ChIP-Seq_ESCs_Human1.23848568
80HTT_18923047_ChIP-ChIP_STHdh_Human1.23703399
81EWS_26573619_Chip-Seq_HEK293_Human1.23146386
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21513562
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21039760
84JUN_21703547_ChIP-Seq_K562_Human1.20899476
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.20503354
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.18498180
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18349902
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18020277
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16115785
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15900595
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15465233
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15078165
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15033994
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.14979266
95RUNX2_22187159_ChIP-Seq_PCA_Human1.14387914
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14091846
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13209758
98TCF4_23295773_ChIP-Seq_U87_Human1.12834499
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.12585968
100P300_18555785_Chip-Seq_ESCs_Mouse1.12202753
101SOX9_26525672_Chip-Seq_HEART_Mouse1.11958127
102* FOXA1_25329375_ChIP-Seq_VCAP_Human1.11315431
103* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11315431
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.10815327
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.10732026
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10682119
107STAT3_23295773_ChIP-Seq_U87_Human1.10301197
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09986183
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.08458621
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07625894
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07481254
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.07346233
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.06960905
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06793759
115POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06277957
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05922581
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05846504
118TP53_18474530_ChIP-ChIP_U2OS_Human1.05575868
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05040539
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.04942892
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04378508
122MYC_18940864_ChIP-ChIP_HL60_Human1.04106492
123TCF4_22108803_ChIP-Seq_LS180_Human1.03977433
124IRF1_19129219_ChIP-ChIP_H3396_Human1.02065222
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.01402708
126* VDR_23849224_ChIP-Seq_CD4+_Human1.01262877
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01042209
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00922221
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00754458
130KDM2B_26808549_Chip-Seq_REH_Human1.00460478
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99973269
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99861772
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.98830020
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98654111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.28049122
2MP0004859_abnormal_synaptic_plasticity2.96669535
3MP0001968_abnormal_touch/_nociception2.92302596
4MP0004270_analgesia2.92246359
5MP0003635_abnormal_synaptic_transmissio2.91911936
6MP0009046_muscle_twitch2.87443128
7MP0009745_abnormal_behavioral_response2.87438722
8MP0002736_abnormal_nociception_after2.81253386
9MP0001188_hyperpigmentation2.73831760
10MP0002064_seizures2.73064739
11MP0006276_abnormal_autonomic_nervous2.58049996
12MP0001529_abnormal_vocalization2.55985991
13MP0002063_abnormal_learning/memory/cond2.50756507
14MP0002272_abnormal_nervous_system2.49937003
15MP0002572_abnormal_emotion/affect_behav2.48727584
16MP0002734_abnormal_mechanical_nocicepti2.45524678
17MP0002735_abnormal_chemical_nociception2.44165889
18MP0001905_abnormal_dopamine_level2.23312696
19MP0001486_abnormal_startle_reflex2.22619653
20MP0005423_abnormal_somatic_nervous2.15966066
21MP0003011_delayed_dark_adaptation2.08639786
22MP0001984_abnormal_olfaction2.05994988
23MP0003195_calcinosis2.04230137
24MP0005646_abnormal_pituitary_gland2.03830523
25MP0002067_abnormal_sensory_capabilities2.03519888
26MP0003787_abnormal_imprinting2.01427413
27MP0000778_abnormal_nervous_system1.98469123
28MP0001440_abnormal_grooming_behavior1.96300409
29MP0005171_absent_coat_pigmentation1.90694037
30MP0000569_abnormal_digit_pigmentation1.90157211
31MP0001501_abnormal_sleep_pattern1.87254194
32MP0002184_abnormal_innervation1.79660796
33MP0004142_abnormal_muscle_tone1.79641474
34MP0002876_abnormal_thyroid_physiology1.77459174
35MP0005084_abnormal_gallbladder_morpholo1.77225476
36MP0003122_maternal_imprinting1.77125128
37MP0001970_abnormal_pain_threshold1.72395560
38MP0002822_catalepsy1.70267248
39MP0005645_abnormal_hypothalamus_physiol1.67460392
40MP0001986_abnormal_taste_sensitivity1.65868725
41MP0003136_yellow_coat_color1.61551357
42MP0002733_abnormal_thermal_nociception1.61179230
43MP0002557_abnormal_social/conspecific_i1.59557946
44MP0002653_abnormal_ependyma_morphology1.54089221
45MP0004924_abnormal_behavior1.47045328
46MP0005386_behavior/neurological_phenoty1.47045328
47MP0002909_abnormal_adrenal_gland1.45845763
48MP0005551_abnormal_eye_electrophysiolog1.39573979
49MP0003879_abnormal_hair_cell1.38066931
50MP0005394_taste/olfaction_phenotype1.36160380
51MP0005499_abnormal_olfactory_system1.36160380
52MP0004742_abnormal_vestibular_system1.35905906
53MP0005410_abnormal_fertilization1.35418638
54MP0004133_heterotaxia1.35384267
55MP0004215_abnormal_myocardial_fiber1.35383710
56MP0002882_abnormal_neuron_morphology1.28849576
57MP0002938_white_spotting1.28717807
58MP0008877_abnormal_DNA_methylation1.26902848
59MP0000516_abnormal_urinary_system1.25158724
60MP0005367_renal/urinary_system_phenotyp1.25158724
61MP0008569_lethality_at_weaning1.25020215
62MP0010386_abnormal_urinary_bladder1.22754594
63MP0005409_darkened_coat_color1.21347771
64MP0004147_increased_porphyrin_level1.19832463
65MP0008789_abnormal_olfactory_epithelium1.19209637
66MP0001963_abnormal_hearing_physiology1.16663045
67MP0002066_abnormal_motor_capabilities/c1.16472736
68MP0000955_abnormal_spinal_cord1.16149933
69MP0004811_abnormal_neuron_physiology1.15147252
70MP0006292_abnormal_olfactory_placode1.15096177
71MP0000372_irregular_coat_pigmentation1.14497017
72MP0000631_abnormal_neuroendocrine_gland1.13914479
73MP0002102_abnormal_ear_morphology1.13041683
74MP0002751_abnormal_autonomic_nervous1.10510077
75MP0002234_abnormal_pharynx_morphology1.09501227
76MP0009780_abnormal_chondrocyte_physiolo1.07806503
77MP0001485_abnormal_pinna_reflex1.07339655
78MP0002090_abnormal_vision1.06263455
79MP0001502_abnormal_circadian_rhythm1.05066546
80MP0002752_abnormal_somatic_nervous1.03987041
81MP0000427_abnormal_hair_cycle1.02482404
82MP0003186_abnormal_redox_activity1.02341774
83MP0009379_abnormal_foot_pigmentation1.01866118
84MP0002837_dystrophic_cardiac_calcinosis1.01108394
85MP0000026_abnormal_inner_ear1.00179083
86MP0002638_abnormal_pupillary_reflex0.97846470
87MP0002229_neurodegeneration0.94098672
88MP0006036_abnormal_mitochondrial_physio0.93589219
89MP0000015_abnormal_ear_pigmentation0.92543289
90MP0006054_spinal_hemorrhage0.90486233
91MP0002152_abnormal_brain_morphology0.89453995
92MP0003121_genomic_imprinting0.86772274
93MP0009697_abnormal_copulation0.84285151
94MP0005379_endocrine/exocrine_gland_phen0.83793065
95MP0006072_abnormal_retinal_apoptosis0.83313261
96MP0002928_abnormal_bile_duct0.83210336
97MP0003137_abnormal_impulse_conducting0.83192143
98MP0001664_abnormal_digestion0.82527787
99MP0002163_abnormal_gland_morphology0.82176074
100MP0000566_synostosis0.82040733
101MP0002160_abnormal_reproductive_system0.79862899
102MP0000920_abnormal_myelination0.79341258
103MP0005195_abnormal_posterior_eye0.78657516
104MP0000647_abnormal_sebaceous_gland0.78253736
105MP0003890_abnormal_embryonic-extraembry0.78001238
106MP0008775_abnormal_heart_ventricle0.77211213
107MP0004145_abnormal_muscle_electrophysio0.76644259
108MP0003698_abnormal_male_reproductive0.75687712
109MP0003634_abnormal_glial_cell0.75297086
110MP0004085_abnormal_heartbeat0.74741535
111MP0008995_early_reproductive_senescence0.74028411
112MP0001756_abnormal_urination0.73952140
113MP0006035_abnormal_mitochondrial_morpho0.73386889
114MP0002069_abnormal_eating/drinking_beha0.73241798
115MP0008260_abnormal_autophagy0.72436458
116MP0003631_nervous_system_phenotype0.72395764
117MP0005253_abnormal_eye_physiology0.72343366
118MP0004885_abnormal_endolymph0.69728213
119MP0008004_abnormal_stomach_pH0.68425068
120MP0000751_myopathy0.68176082
121MP0003329_amyloid_beta_deposits0.68126913
122MP0003938_abnormal_ear_development0.65982975
123MP0003633_abnormal_nervous_system0.65505100
124MP0000013_abnormal_adipose_tissue0.64691210
125MP0008872_abnormal_physiological_respon0.64561115
126MP0004043_abnormal_pH_regulation0.64351504
127MP0004134_abnormal_chest_morphology0.59832607

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.67097427
2Atonic seizures (HP:0010819)4.94723628
3Acute necrotizing encephalopathy (HP:0006965)4.61473435
4Hyperventilation (HP:0002883)4.43608858
5Epileptic encephalopathy (HP:0200134)4.40155415
6Abnormal mitochondria in muscle tissue (HP:0008316)4.19434252
7Febrile seizures (HP:0002373)4.15816620
8Medial flaring of the eyebrow (HP:0010747)4.04714907
9Progressive macrocephaly (HP:0004481)4.03666176
10Gait imbalance (HP:0002141)3.94202769
11Congenital primary aphakia (HP:0007707)3.77339238
12Abnormal hair whorl (HP:0010721)3.63705102
13Nephrogenic diabetes insipidus (HP:0009806)3.62670941
14Mitochondrial inheritance (HP:0001427)3.62081487
15Hypothermia (HP:0002045)3.61433380
16Acute encephalopathy (HP:0006846)3.42228944
17Focal seizures (HP:0007359)3.38800584
18Pancreatic cysts (HP:0001737)3.30093764
19Genital tract atresia (HP:0001827)3.10115733
20Vaginal atresia (HP:0000148)3.08906000
21Increased CSF lactate (HP:0002490)3.08075673
22Absence seizures (HP:0002121)2.99359188
23Myokymia (HP:0002411)2.93004877
24Optic disc pallor (HP:0000543)2.92995555
25Increased serum pyruvate (HP:0003542)2.89857148
26Abnormality of glycolysis (HP:0004366)2.89857148
27Dialeptic seizures (HP:0011146)2.88050056
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.86260982
29Absent/shortened dynein arms (HP:0200106)2.86260982
30Hepatocellular necrosis (HP:0001404)2.85530619
31Poor coordination (HP:0002370)2.80181514
32Broad-based gait (HP:0002136)2.78682377
33Progressive cerebellar ataxia (HP:0002073)2.78236990
34Renal cortical cysts (HP:0000803)2.74659209
35Generalized aminoaciduria (HP:0002909)2.73193734
36Methylmalonic acidemia (HP:0002912)2.69282635
37Pheochromocytoma (HP:0002666)2.63601077
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62658398
39Abnormality of alanine metabolism (HP:0010916)2.62658398
40Hyperalaninemia (HP:0003348)2.62658398
41Limb dystonia (HP:0002451)2.51333717
42Polyphagia (HP:0002591)2.50388561
43Sensory axonal neuropathy (HP:0003390)2.50262091
44Neuroendocrine neoplasm (HP:0100634)2.47999046
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.47992280
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47992280
47Abnormal ciliary motility (HP:0012262)2.47678484
48Generalized tonic-clonic seizures (HP:0002069)2.44183290
49Leukodystrophy (HP:0002415)2.42531204
50Aplasia/Hypoplasia of the lens (HP:0008063)2.39303945
51Abnormality of the renal cortex (HP:0011035)2.37305079
52Poor suck (HP:0002033)2.36503153
53Pancreatic fibrosis (HP:0100732)2.35593825
54Type II lissencephaly (HP:0007260)2.35222367
55Abnormal respiratory epithelium morphology (HP:0012253)2.32115399
56Abnormal respiratory motile cilium morphology (HP:0005938)2.32115399
57Amblyopia (HP:0000646)2.30525150
58Gaze-evoked nystagmus (HP:0000640)2.30518787
59Progressive inability to walk (HP:0002505)2.29712672
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29525526
61Lissencephaly (HP:0001339)2.27616196
62Abnormal respiratory motile cilium physiology (HP:0012261)2.27155028
63Abnormality of renal resorption (HP:0011038)2.25430804
64Abnormal drinking behavior (HP:0030082)2.24348409
65Polydipsia (HP:0001959)2.24348409
66Specific learning disability (HP:0001328)2.19834444
67Abnormality of macular pigmentation (HP:0008002)2.19425023
68Intestinal atresia (HP:0011100)2.16084010
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15842947
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15842947
71True hermaphroditism (HP:0010459)2.15593183
72Protruding tongue (HP:0010808)2.12755197
73Esotropia (HP:0000565)2.12669779
74Lipid accumulation in hepatocytes (HP:0006561)2.12418825
75Abolished electroretinogram (ERG) (HP:0000550)2.11391049
76Abnormality of the renal medulla (HP:0100957)2.11378111
77Hemiparesis (HP:0001269)2.11113022
78Hypoglycemic coma (HP:0001325)2.09951924
79Methylmalonic aciduria (HP:0012120)2.09893728
80Short tibia (HP:0005736)2.09719152
81Inability to walk (HP:0002540)2.08332974
823-Methylglutaconic aciduria (HP:0003535)2.08103178
83Visual hallucinations (HP:0002367)2.07551539
84Abnormality of urine glucose concentration (HP:0011016)2.07272506
85Glycosuria (HP:0003076)2.07272506
86Pachygyria (HP:0001302)2.06854403
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06844976
88Ketoacidosis (HP:0001993)2.06843627
89Hypsarrhythmia (HP:0002521)2.06286932
90Aplasia/Hypoplasia of the tibia (HP:0005772)2.06178952
91Exercise intolerance (HP:0003546)2.05997209
92Abnormal eating behavior (HP:0100738)2.04560201
93Parakeratosis (HP:0001036)2.03859605
94Renal Fanconi syndrome (HP:0001994)2.01918062
95Agitation (HP:0000713)1.98886370
96Epileptiform EEG discharges (HP:0011182)1.98065624
97Muscular hypotonia of the trunk (HP:0008936)1.97452403
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97376874
99Hepatic necrosis (HP:0002605)1.97359530
100Increased hepatocellular lipid droplets (HP:0006565)1.97140618
101Respiratory failure (HP:0002878)1.96445206
102Abnormality of the corticospinal tract (HP:0002492)1.96401197
103Hypoglycemic seizures (HP:0002173)1.96382390
104Delayed gross motor development (HP:0002194)1.95897143
105Fetal akinesia sequence (HP:0001989)1.95055185
106Nephronophthisis (HP:0000090)1.93745325
107Abnormality of the labia minora (HP:0012880)1.91680431
108Congenital stationary night blindness (HP:0007642)1.90646044
109Decreased testicular size (HP:0008734)1.89793867
110Lactic acidosis (HP:0003128)1.89454529
111Retinal dysplasia (HP:0007973)1.87011209
112Absent speech (HP:0001344)1.86520511
113Hyperthyroidism (HP:0000836)1.85908917
114X-linked dominant inheritance (HP:0001423)1.85546285
115Sclerocornea (HP:0000647)1.85508485
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.85049767
117Failure to thrive in infancy (HP:0001531)1.84449362
118Thyroid-stimulating hormone excess (HP:0002925)1.84378870
119Blue irides (HP:0000635)1.84135995
120Truncal ataxia (HP:0002078)1.83734354
121Left ventricular hypertrophy (HP:0001712)1.83666219
122Cerebral edema (HP:0002181)1.82465344
123Optic nerve hypoplasia (HP:0000609)1.82384454
124Hyperinsulinemic hypoglycemia (HP:0000825)1.80583993
125Thickened helices (HP:0000391)1.80369048
126Abnormality of midbrain morphology (HP:0002418)1.80165845
127Molar tooth sign on MRI (HP:0002419)1.80165845
128Broad foot (HP:0001769)1.80105121
129Postaxial hand polydactyly (HP:0001162)1.79503734
130Decreased muscle mass (HP:0003199)1.79242155
131Drooling (HP:0002307)1.78359413
132Excessive salivation (HP:0003781)1.78359413
133Occipital encephalocele (HP:0002085)1.76322283
134Large for gestational age (HP:0001520)1.76255675
135Amyotrophic lateral sclerosis (HP:0007354)1.75270226
136Hypomagnesemia (HP:0002917)1.75177181
137Adrenal hypoplasia (HP:0000835)1.73575793
138Narrow nasal bridge (HP:0000446)1.73050895
139Increased serum lactate (HP:0002151)1.71749338
140Asthma (HP:0002099)1.70689691
141EEG with generalized epileptiform discharges (HP:0011198)1.69849333
142Impaired vibration sensation in the lower limbs (HP:0002166)1.69281956
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.64110365
144Autoamputation (HP:0001218)1.63069613
145Anxiety (HP:0000739)1.61723102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.78837603
2FRK3.54734113
3MAP2K73.27566178
4TRIM283.24214246
5MAP4K22.92710577
6MAP3K122.77825652
7AKT32.52239918
8MAP3K42.50965342
9PLK22.43586053
10NTRK32.40838914
11CDK192.39742695
12OXSR12.08090287
13MARK12.05049110
14EPHA41.97450953
15MAPK131.85925140
16PRPF4B1.85616082
17PINK11.82177579
18PAK31.67071074
19BCR1.63973418
20CCNB11.63533418
21BMPR21.62318978
22TNIK1.62228412
23STK161.58099312
24MINK11.56286674
25SIK31.55271391
26TSSK61.52021057
27STK391.49398224
28BCKDK1.39681279
29NME11.39010665
30MAP2K41.34873653
31BMPR1B1.33238134
32CSNK1G11.33123269
33DAPK21.31894917
34DAPK11.28364852
35EPHA31.26667854
36SGK4941.25643256
37SGK2231.25643256
38BRAF1.24859901
39PHKG11.23691927
40PHKG21.23691927
41PNCK1.21013652
42CAMK2B1.18694277
43ADRBK21.15070162
44GRK51.14385870
45EIF2AK31.11037979
46YES11.10356986
47ARAF1.09616387
48SGK21.09406540
49TESK11.08298462
50CAMK2A1.05252361
51PRKCG1.04937791
52ERBB31.03498117
53PDK41.03241427
54PDK31.03241427
55ZAK1.03018763
56NTRK21.02400302
57ACVR1B0.98835485
58MUSK0.98801929
59FLT30.97791957
60GRK70.95844306
61CSNK1A1L0.95032039
62MST40.94275676
63MYLK0.90704501
64PRKCE0.90272858
65NUAK10.89349253
66DYRK20.88149667
67UHMK10.85542555
68CDK50.85410808
69WNK40.81749888
70WNK30.81139776
71MAPKAPK50.79516913
72EIF2AK10.79447557
73PDK20.79344489
74NEK60.76322506
75CAMK2D0.75253897
76FGFR20.75101958
77PKN10.75016538
78CDK30.74707601
79PTK2B0.74051355
80NEK10.73007253
81MKNK20.72398728
82ADRBK10.71616923
83FES0.70861245
84TIE10.70413034
85CDK180.69328096
86DYRK1A0.66532824
87CDK140.66104211
88CSNK1G30.64716941
89CAMKK20.64191812
90TLK10.63574932
91KIT0.63249033
92VRK10.63132878
93CDK80.60963773
94PLK30.60490650
95CSNK1G20.59530268
96CDK150.58217197
97STK38L0.57857208
98CAMK2G0.57815406
99ROCK20.57442026
100OBSCN0.56313575
101RIPK40.54631026
102PLK40.54386680
103LIMK10.54301873
104TAOK30.53712715
105SRPK10.52595519
106KSR10.50380784
107CDK11A0.50361778
108TNK20.48274590
109ERBB40.47642133
110INSRR0.47291321
111PRKACA0.43267207
112DYRK30.43097886
113FGR0.41420604
114FER0.40970609
115EPHB20.39742678
116PRKG10.39610628
117MAP3K50.39575049
118PRKACB0.39481919
119RPS6KA40.38977600
120IRAK20.38398825
121GRK10.37578025
122CSNK1A10.37282418
123PBK0.36650202
124MKNK10.36197117
125BUB10.35541159
126SGK10.35467863
127IRAK10.34983186
128PRKCA0.34161274
129SCYL20.33237055
130ABL20.32809158
131PRKCI0.32562789
132DAPK30.32561264
133WNK10.32027615
134PAK60.31039206
135SGK30.31023178
136MAP3K60.30081057

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.88952489
2Nicotine addiction_Homo sapiens_hsa050333.87095189
3Collecting duct acid secretion_Homo sapiens_hsa049663.63006038
4Synaptic vesicle cycle_Homo sapiens_hsa047213.48393545
5Parkinsons disease_Homo sapiens_hsa050122.89325512
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61152419
7Alzheimers disease_Homo sapiens_hsa050102.42131106
8Vibrio cholerae infection_Homo sapiens_hsa051102.30899684
9GABAergic synapse_Homo sapiens_hsa047272.24252463
10Butanoate metabolism_Homo sapiens_hsa006502.18298119
11Huntingtons disease_Homo sapiens_hsa050162.16349245
12Morphine addiction_Homo sapiens_hsa050322.15729988
13Amphetamine addiction_Homo sapiens_hsa050312.05379158
14Circadian entrainment_Homo sapiens_hsa047132.03217362
15Serotonergic synapse_Homo sapiens_hsa047262.02878495
16Phototransduction_Homo sapiens_hsa047442.00464346
17Olfactory transduction_Homo sapiens_hsa047402.00367659
18Taste transduction_Homo sapiens_hsa047421.99690091
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.98616105
20Glutamatergic synapse_Homo sapiens_hsa047241.93568391
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91216623
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86440981
23Dopaminergic synapse_Homo sapiens_hsa047281.85600303
24Proteasome_Homo sapiens_hsa030501.85522467
25Propanoate metabolism_Homo sapiens_hsa006401.79865768
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74531035
27Protein export_Homo sapiens_hsa030601.70877212
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67469289
29Long-term potentiation_Homo sapiens_hsa047201.64470982
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.61760076
31Long-term depression_Homo sapiens_hsa047301.51306402
32Cardiac muscle contraction_Homo sapiens_hsa042601.42922527
33Rheumatoid arthritis_Homo sapiens_hsa053231.42617289
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41149315
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39093368
36Cocaine addiction_Homo sapiens_hsa050301.32098605
37Insulin secretion_Homo sapiens_hsa049111.30459154
38Peroxisome_Homo sapiens_hsa041461.27191818
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26644139
40Nitrogen metabolism_Homo sapiens_hsa009101.25557830
41Salivary secretion_Homo sapiens_hsa049701.23160165
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21288986
43Cholinergic synapse_Homo sapiens_hsa047251.18848610
44Fatty acid elongation_Homo sapiens_hsa000621.16536585
45Calcium signaling pathway_Homo sapiens_hsa040201.16217720
46Renin secretion_Homo sapiens_hsa049241.16137136
47Axon guidance_Homo sapiens_hsa043601.15367744
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.14838973
49Tryptophan metabolism_Homo sapiens_hsa003801.12016694
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08873028
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08520570
52Phagosome_Homo sapiens_hsa041451.00848045
53Caffeine metabolism_Homo sapiens_hsa002320.97056061
54Folate biosynthesis_Homo sapiens_hsa007900.95863426
55RNA polymerase_Homo sapiens_hsa030200.94290822
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94098150
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89112472
58Gastric acid secretion_Homo sapiens_hsa049710.86803246
59beta-Alanine metabolism_Homo sapiens_hsa004100.86535570
60Ether lipid metabolism_Homo sapiens_hsa005650.85919093
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83776476
62Selenocompound metabolism_Homo sapiens_hsa004500.83727900
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83512862
64Oxytocin signaling pathway_Homo sapiens_hsa049210.82102439
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78400326
66Sphingolipid metabolism_Homo sapiens_hsa006000.76052426
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75359038
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74754655
69Regulation of autophagy_Homo sapiens_hsa041400.72971461
70Pyruvate metabolism_Homo sapiens_hsa006200.72915760
71RNA degradation_Homo sapiens_hsa030180.71398859
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68522887
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66787305
74Alcoholism_Homo sapiens_hsa050340.66729640
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66723454
76Gap junction_Homo sapiens_hsa045400.66231561
77Fatty acid metabolism_Homo sapiens_hsa012120.64913956
78Type I diabetes mellitus_Homo sapiens_hsa049400.64484982
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63418516
80Basal transcription factors_Homo sapiens_hsa030220.63307069
81cAMP signaling pathway_Homo sapiens_hsa040240.61571043
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.61243083
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58356679
84Chemical carcinogenesis_Homo sapiens_hsa052040.57659639
85Glutathione metabolism_Homo sapiens_hsa004800.57419274
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56590527
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55060343
88Melanogenesis_Homo sapiens_hsa049160.53211400
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52107105
90Sulfur metabolism_Homo sapiens_hsa009200.50589724
91ErbB signaling pathway_Homo sapiens_hsa040120.50399072
92Vitamin B6 metabolism_Homo sapiens_hsa007500.48868983
93Steroid biosynthesis_Homo sapiens_hsa001000.48583379
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48488224
95Retinol metabolism_Homo sapiens_hsa008300.47749354
96Non-homologous end-joining_Homo sapiens_hsa034500.47139631
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46772345
98Purine metabolism_Homo sapiens_hsa002300.46091703
99Ras signaling pathway_Homo sapiens_hsa040140.46074377
100GnRH signaling pathway_Homo sapiens_hsa049120.45558281
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45406939
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.43294401
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42282118
104Fat digestion and absorption_Homo sapiens_hsa049750.41654452
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41338348
106Autoimmune thyroid disease_Homo sapiens_hsa053200.40721375
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38586146
108Oocyte meiosis_Homo sapiens_hsa041140.37467276
109MAPK signaling pathway_Homo sapiens_hsa040100.35060043
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34737871
111Fatty acid degradation_Homo sapiens_hsa000710.32596573
112Circadian rhythm_Homo sapiens_hsa047100.32310964
113Metabolic pathways_Homo sapiens_hsa011000.31248554
114Wnt signaling pathway_Homo sapiens_hsa043100.30117380
115Mineral absorption_Homo sapiens_hsa049780.29710294
116N-Glycan biosynthesis_Homo sapiens_hsa005100.29591607
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29505715
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28662263
119Pyrimidine metabolism_Homo sapiens_hsa002400.28270791
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27707350
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26572450
122Arachidonic acid metabolism_Homo sapiens_hsa005900.25607715
123Pancreatic secretion_Homo sapiens_hsa049720.23355335
124Melanoma_Homo sapiens_hsa052180.22741645
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22617914
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21614220
127Hedgehog signaling pathway_Homo sapiens_hsa043400.21220919
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.20079981
129Ovarian steroidogenesis_Homo sapiens_hsa049130.19558254
130Linoleic acid metabolism_Homo sapiens_hsa005910.19542502
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18606304
132Estrogen signaling pathway_Homo sapiens_hsa049150.17774108
133African trypanosomiasis_Homo sapiens_hsa051430.16813965
134Tyrosine metabolism_Homo sapiens_hsa003500.16518041
135Phenylalanine metabolism_Homo sapiens_hsa003600.14927583
136Ribosome_Homo sapiens_hsa030100.11196589
137Dilated cardiomyopathy_Homo sapiens_hsa054140.09618388
138Thyroid hormone synthesis_Homo sapiens_hsa049180.08211521

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