ACTL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.88900328
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.80723110
3regulation of retinoic acid receptor signaling pathway (GO:0048385)8.39111826
4multicellular organism reproduction (GO:0032504)7.72802982
5piRNA metabolic process (GO:0034587)7.56707752
6oocyte development (GO:0048599)7.54714484
7meiotic cell cycle (GO:0051321)7.44775438
8regulation of meiosis I (GO:0060631)7.23776959
9protein kinase C signaling (GO:0070528)6.51437826
10positive regulation of histone H3-K4 methylation (GO:0051571)6.48137668
11regulation of histone H3-K9 methylation (GO:0051570)6.36772158
12negative regulation of reproductive process (GO:2000242)6.34381345
13DNA methylation involved in gamete generation (GO:0043046)6.10779874
14female gamete generation (GO:0007292)6.03222400
15retinal cone cell development (GO:0046549)6.00949736
16positive regulation of humoral immune response (GO:0002922)5.86873697
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.69780119
18mitotic chromosome condensation (GO:0007076)5.67933424
19regulation of steroid hormone secretion (GO:2000831)5.42560279
20glycine transport (GO:0015816)5.41499025
21negative regulation of histone methylation (GO:0031061)5.41364270
22regulation of cell maturation (GO:1903429)5.22772646
23reproduction (GO:0000003)5.18217236
24protein localization to chromosome, centromeric region (GO:0071459)4.83973289
25mitotic metaphase plate congression (GO:0007080)4.81479512
26positive regulation of mitotic sister chromatid separation (GO:1901970)4.76276840
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.76276840
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.76276840
29positive regulation of gastrulation (GO:2000543)4.74552172
30protein localization to kinetochore (GO:0034501)4.68249899
31gene silencing by RNA (GO:0031047)4.66929807
32binding of sperm to zona pellucida (GO:0007339)4.64544835
33positive regulation of chromosome segregation (GO:0051984)4.57013222
34citrulline biosynthetic process (GO:0019240)4.37145867
35regulation of spindle organization (GO:0090224)4.31059501
36establishment of chromosome localization (GO:0051303)4.27489896
37primitive streak formation (GO:0090009)4.24127802
38positive regulation of reproductive process (GO:2000243)4.20870784
39male meiosis I (GO:0007141)4.09968198
40regulation of meiosis (GO:0040020)4.04567186
41fertilization (GO:0009566)4.01241843
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94996589
43positive regulation of histone methylation (GO:0031062)3.94688868
44positive regulation of uterine smooth muscle contraction (GO:0070474)3.90617467
45metaphase plate congression (GO:0051310)3.89559352
46regulation of histone H3-K4 methylation (GO:0051569)3.88701557
47synapsis (GO:0007129)3.87084955
48centriole replication (GO:0007099)3.87083354
49attachment of spindle microtubules to kinetochore (GO:0008608)3.85347225
50single fertilization (GO:0007338)3.81834621
51regulation of steroid hormone biosynthetic process (GO:0090030)3.81609695
52L-amino acid import (GO:0043092)3.79578592
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74647480
54synaptonemal complex assembly (GO:0007130)3.66446795
55regulation of reproductive process (GO:2000241)3.64623797
56CENP-A containing nucleosome assembly (GO:0034080)3.62131492
57protein localization to chromosome (GO:0034502)3.60495483
58sperm-egg recognition (GO:0035036)3.56234372
59DNA alkylation (GO:0006305)3.56131854
60DNA methylation (GO:0006306)3.56131854
61meiosis I (GO:0007127)3.54293824
62phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.52402689
63male meiosis (GO:0007140)3.49578556
64regulation of histone methylation (GO:0031060)3.48277856
65N-terminal protein amino acid acetylation (GO:0006474)3.45431439
66phosphorelay signal transduction system (GO:0000160)3.44195297
67regulation of calcium ion-dependent exocytosis (GO:0017158)3.43811626
68chromosome organization involved in meiosis (GO:0070192)3.42700058
69DNA replication checkpoint (GO:0000076)3.42089242
70negative regulation of execution phase of apoptosis (GO:1900118)3.33553136
71regulation of meiotic cell cycle (GO:0051445)3.32829299
72oogenesis (GO:0048477)3.32643053
73DNA replication-dependent nucleosome organization (GO:0034723)3.31821413
74DNA replication-dependent nucleosome assembly (GO:0006335)3.31821413
75synaptonemal complex organization (GO:0070193)3.31779661
76meiotic cell cycle process (GO:1903046)3.25318631
77meiotic nuclear division (GO:0007126)3.25136262
78gene silencing (GO:0016458)3.24190429
79chromatin remodeling at centromere (GO:0031055)3.24033357
80regulation of spindle checkpoint (GO:0090231)3.21705432
81negative regulation of hormone biosynthetic process (GO:0032353)3.17930966
82regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.12695166
83hyperosmotic salinity response (GO:0042538)3.12631689
84negative regulation of hormone metabolic process (GO:0032351)3.08743031
85nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.08343355
86regulation of hypersensitivity (GO:0002883)3.07830880
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.07769787
88histone phosphorylation (GO:0016572)3.06488372
89positive regulation of DNA-dependent DNA replication (GO:2000105)3.06396831
90neuron fate determination (GO:0048664)3.05812765
91histone H3-K9 demethylation (GO:0033169)3.05046404
92translesion synthesis (GO:0019985)3.03896365
93regulation of corticosteroid hormone secretion (GO:2000846)3.02981256
94aggressive behavior (GO:0002118)3.02139061
95negative regulation of histone modification (GO:0031057)3.01407919
96labyrinthine layer development (GO:0060711)2.99932219
97DNA damage induced protein phosphorylation (GO:0006975)2.96599865
98regulation of uterine smooth muscle contraction (GO:0070472)2.93400280
99regulation of female gonad development (GO:2000194)10.4729375
100regulation of DNA methylation (GO:0044030)10.2213879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.22882293
2E2F7_22180533_ChIP-Seq_HELA_Human4.84601159
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.68443684
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.20818822
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.67217015
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38908766
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38908766
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38908766
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95114836
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.93482316
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89915627
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71254009
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.49180977
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34655508
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20938136
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01962987
17EZH2_22144423_ChIP-Seq_EOC_Human14.7809064
18AR_21909140_ChIP-Seq_LNCAP_Human1.98519801
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82321996
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.79247434
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74653280
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71190014
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.69742811
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.61986539
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59893068
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51891927
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48450036
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25070580
29GBX2_23144817_ChIP-Seq_PC3_Human1.24122657
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22363760
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21127368
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19955722
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09764087
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.07673523
35NANOG_20526341_ChIP-Seq_ESCs_Human1.06948206
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04341608
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00991168
38IRF1_19129219_ChIP-ChIP_H3396_Human1.00384135
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96310380
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94131476
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88973029
42FOXP3_21729870_ChIP-Seq_TREG_Human0.88524430
43PRDM14_20953172_ChIP-Seq_ESCs_Human0.87631352
44GF1_26923725_Chip-Seq_HPCs_Mouse0.84768473
45EST1_17652178_ChIP-ChIP_JURKAT_Human0.84500574
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83869117
47TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83743636
48YY1_21170310_ChIP-Seq_MESCs_Mouse0.82575347
49THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81795416
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81754603
51TCF4_23295773_ChIP-Seq_U87_Human0.81096936
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79907933
53CBP_20019798_ChIP-Seq_JUKART_Human0.79869653
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79869653
55CBP_21632823_ChIP-Seq_H3396_Human0.79069208
56HTT_18923047_ChIP-ChIP_STHdh_Human0.77274442
57NELFA_20434984_ChIP-Seq_ESCs_Mouse0.76340069
58FOXH1_21741376_ChIP-Seq_EPCs_Human0.76294340
59GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76221266
60SMAD4_21741376_ChIP-Seq_EPCs_Human0.75440704
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75229301
62FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74953544
63LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74110764
64MYC_18940864_ChIP-ChIP_HL60_Human0.73397072
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72440527
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71267529
67PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71073773
68PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70368232
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69872096
70RUNX2_22187159_ChIP-Seq_PCA_Human0.69461082
71SALL4_22934838_ChIP-ChIP_CD34+_Human0.67255176
72MYC_19079543_ChIP-ChIP_MESCs_Mouse0.64718096
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.64612264
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.63900161
75TP53_22573176_ChIP-Seq_HFKS_Human0.61938343
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.61695710
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.61608280
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.61608280
79* AR_25329375_ChIP-Seq_VCAP_Human0.61384335
80SMRT_27268052_Chip-Seq_Bcells_Human0.60192473
81GABP_17652178_ChIP-ChIP_JURKAT_Human0.60117357
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.57910274
83* KLF4_19829295_ChIP-Seq_ESCs_Human0.56854151
84STAT3_23295773_ChIP-Seq_U87_Human0.56599635
85* SMAD4_21799915_ChIP-Seq_A2780_Human0.56376088
86BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.55606500
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.55470453
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.54726802
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.52971116
90AHR_22903824_ChIP-Seq_MCF-7_Human0.51270133
91GATA3_26560356_Chip-Seq_TH1_Human0.51089499
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.49726534
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.49139830
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.48946610
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.48842758
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.48359178
97SOX2_21211035_ChIP-Seq_LN229_Human0.48021432
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.47561856
99VDR_23849224_ChIP-Seq_CD4+_Human0.47365204
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.46935867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.60805173
2MP0006292_abnormal_olfactory_placode4.96287434
3MP0008789_abnormal_olfactory_epithelium4.14247647
4MP0008877_abnormal_DNA_methylation4.11030518
5MP0005499_abnormal_olfactory_system3.78423011
6MP0005394_taste/olfaction_phenotype3.78423011
7MP0005395_other_phenotype3.40775132
8MP0003693_abnormal_embryo_hatching3.26822681
9MP0008057_abnormal_DNA_replication2.99403035
10MP0010030_abnormal_orbit_morphology2.86905440
11MP0002139_abnormal_hepatobiliary_system2.83376086
12MP0003890_abnormal_embryonic-extraembry2.82569078
13MP0003699_abnormal_female_reproductive2.61877676
14MP0010234_abnormal_vibrissa_follicle2.47697566
15MP0002234_abnormal_pharynx_morphology2.43354909
16MP0003077_abnormal_cell_cycle2.39354264
17MP0005360_urolithiasis2.37315359
18MP0002138_abnormal_hepatobiliary_system2.30143650
19MP0001929_abnormal_gametogenesis2.29645603
20MP0003879_abnormal_hair_cell2.18482454
21MP0008058_abnormal_DNA_repair2.14196340
22MP0002210_abnormal_sex_determination2.10419288
23MP0010094_abnormal_chromosome_stability2.10308948
24MP0003111_abnormal_nucleus_morphology2.00201226
25MP0005410_abnormal_fertilization1.76450141
26MP0010307_abnormal_tumor_latency1.75804127
27MP0003950_abnormal_plasma_membrane1.72882952
28MP0002161_abnormal_fertility/fecundity1.69893399
29MP0000653_abnormal_sex_gland1.69877189
30MP0000566_synostosis1.62187331
31MP0008932_abnormal_embryonic_tissue1.57257881
32MP0002160_abnormal_reproductive_system1.53992567
33MP0001730_embryonic_growth_arrest1.53321776
34MP0003183_abnormal_peptide_metabolism1.47579136
35MP0009840_abnormal_foam_cell1.43533400
36MP0001119_abnormal_female_reproductive1.41742871
37MP0001293_anophthalmia1.37561315
38MP0005646_abnormal_pituitary_gland1.33684772
39MP0003121_genomic_imprinting1.30017954
40MP0001145_abnormal_male_reproductive1.26857084
41MP0000762_abnormal_tongue_morphology1.26814999
42MP0005647_abnormal_sex_gland1.15018795
43MP0005389_reproductive_system_phenotype1.14808804
44MP0000631_abnormal_neuroendocrine_gland1.14286211
45MP0002233_abnormal_nose_morphology1.14149725
46MP0001672_abnormal_embryogenesis/_devel1.12835044
47MP0005380_embryogenesis_phenotype1.12835044
48MP0010368_abnormal_lymphatic_system1.11306438
49MP0004957_abnormal_blastocyst_morpholog1.10210545
50MP0001986_abnormal_taste_sensitivity1.09589805
51MP0003698_abnormal_male_reproductive1.06298161
52MP0000350_abnormal_cell_proliferation1.06291881
53MP0009379_abnormal_foot_pigmentation1.03620471
54MP0000427_abnormal_hair_cycle1.01708653
55MP0003252_abnormal_bile_duct1.00213208
56MP0001984_abnormal_olfaction0.94165909
57MP0004142_abnormal_muscle_tone0.89614202
58MP0000678_abnormal_parathyroid_gland0.85453433
59MP0003119_abnormal_digestive_system0.84312715
60MP0001666_abnormal_nutrient_absorption0.83111785
61MP0006276_abnormal_autonomic_nervous0.80169965
62MP0000049_abnormal_middle_ear0.79702426
63MP0010678_abnormal_skin_adnexa0.78078593
64MP0003941_abnormal_skin_development0.75182748
65MP0001664_abnormal_digestion0.74587623
66MP0002796_impaired_skin_barrier0.74585483
67MP0005085_abnormal_gallbladder_physiolo0.73856814
68MP0002272_abnormal_nervous_system0.71719146
69MP0005501_abnormal_skin_physiology0.69740207
70MP0002127_abnormal_cardiovascular_syste0.64268417
71MP0001324_abnormal_eye_pigmentation0.64030136
72MP0002084_abnormal_developmental_patter0.63486012
73MP0003136_yellow_coat_color0.62609304
74MP0005551_abnormal_eye_electrophysiolog0.56350932
75MP0001502_abnormal_circadian_rhythm0.56342800
76MP0003984_embryonic_growth_retardation0.56164662
77MP0001881_abnormal_mammary_gland0.55854059
78MP0001697_abnormal_embryo_size0.55396371
79MP0002085_abnormal_embryonic_tissue0.51855001
80MP0002088_abnormal_embryonic_growth/wei0.51836470
81MP0003868_abnormal_feces_composition0.51541883
82MP0003935_abnormal_craniofacial_develop0.49124617
83MP0005075_abnormal_melanosome_morpholog0.46051940
84MP0000313_abnormal_cell_death0.45737598
85MP0003786_premature_aging0.44474993
86MP0000015_abnormal_ear_pigmentation0.43020461
87MP0005076_abnormal_cell_differentiation0.42913218
88MP0000377_abnormal_hair_follicle0.41121842
89MP0000733_abnormal_muscle_development0.40870238
90MP0002873_normal_phenotype0.40800878
91MP0000428_abnormal_craniofacial_morphol0.40722033
92MP0001919_abnormal_reproductive_system0.40671374
93MP0001963_abnormal_hearing_physiology0.40393627
94MP0002169_no_abnormal_phenotype0.40391790
95MP0002089_abnormal_postnatal_growth/wei0.40184238
96MP0003755_abnormal_palate_morphology0.40016602
97MP0002080_prenatal_lethality0.39396306
98MP0002751_abnormal_autonomic_nervous0.39092578
99MP0000627_abnormal_mammary_gland0.39027473
100MP0005319_abnormal_enzyme/_coenzyme0.38094290

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.93044442
2Supernumerary spleens (HP:0009799)5.35213975
3Abdominal situs inversus (HP:0003363)5.21254466
4Abnormality of abdominal situs (HP:0011620)5.21254466
5Hypoplasia of the fovea (HP:0007750)4.92947098
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.92947098
7Cholecystitis (HP:0001082)4.92168961
8Abnormal gallbladder physiology (HP:0012438)4.92168961
9Impulsivity (HP:0100710)4.79624820
10Male infertility (HP:0003251)4.79079179
11Anterior segment dysgenesis (HP:0007700)4.59085581
12Facial hemangioma (HP:0000329)4.58428932
13Osteomalacia (HP:0002749)4.48682768
14Lip pit (HP:0100267)4.43996188
15Septo-optic dysplasia (HP:0100842)4.17956227
16Abnormality of the fovea (HP:0000493)4.10594968
17Hypophosphatemic rickets (HP:0004912)4.05586457
18Papillary thyroid carcinoma (HP:0002895)4.03025025
19Hypokinesia (HP:0002375)4.01617641
20Premature ovarian failure (HP:0008209)3.95916880
21Oligodactyly (hands) (HP:0001180)3.94996828
22Infertility (HP:0000789)3.80629967
23Chromsome breakage (HP:0040012)3.74833310
24Malnutrition (HP:0004395)3.73949552
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72755704
26Apathy (HP:0000741)3.64389797
27Median cleft lip (HP:0000161)3.57107473
28Absent septum pellucidum (HP:0001331)3.56781718
29Diminished motivation (HP:0000745)3.49399875
30Azoospermia (HP:0000027)3.45857064
31Abnormality of the septum pellucidum (HP:0007375)3.11605156
32Aplasia/Hypoplasia of the macula (HP:0008059)3.11005407
33Short tibia (HP:0005736)3.09873416
34Gonadotropin excess (HP:0000837)3.07987848
35Oligodactyly (HP:0012165)3.02076674
36Abnormality of the labia minora (HP:0012880)2.92805247
37Aplasia/Hypoplasia affecting the retina (HP:0008061)2.85052805
38Muscle stiffness (HP:0003552)2.77305351
39Lower limb hyperreflexia (HP:0002395)2.74537493
40Abnormal spermatogenesis (HP:0008669)2.72156222
41Spinal cord compression (HP:0002176)2.69789910
42Capillary hemangiomas (HP:0005306)2.69383725
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.68951087
44Aplasia of the musculature (HP:0100854)2.66437975
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63826772
46Hypergonadotropic hypogonadism (HP:0000815)2.61009287
47Urethral obstruction (HP:0000796)2.59411781
48Skin pits (HP:0100276)2.40001023
49Myokymia (HP:0002411)2.38882120
50Enlarged penis (HP:0000040)2.38136924
51Maternal diabetes (HP:0009800)2.37736596
52Wrist flexion contracture (HP:0001239)2.37385462
53Sensory axonal neuropathy (HP:0003390)2.29613033
54Conjunctival telangiectasia (HP:0000524)2.28632603
55Intrahepatic cholestasis (HP:0001406)2.28042106
56Truncal obesity (HP:0001956)2.27554435
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24451904
58Metaphyseal irregularity (HP:0003025)2.23830238
59Stillbirth (HP:0003826)2.23813750
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.23363455
61Generalized aminoaciduria (HP:0002909)2.21125739
62Proximal tubulopathy (HP:0000114)2.19002482
63Loss of speech (HP:0002371)2.18115360
64Striae distensae (HP:0001065)2.16288563
65Posterior subcapsular cataract (HP:0007787)2.16129418
66Thyroid carcinoma (HP:0002890)2.14609350
67Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.13886805
68Anhidrosis (HP:0000970)2.11566242
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09648644
70Abnormal lung lobation (HP:0002101)2.07343467
71Bundle branch block (HP:0011710)2.06045317
72Fair hair (HP:0002286)2.05007620
73Secondary amenorrhea (HP:0000869)2.04109149
74Abnormality of the preputium (HP:0100587)2.00289012
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.98775695
76Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98191724
77Dysdiadochokinesis (HP:0002075)1.96769309
78Abnormality of the phalanges of the hallux (HP:0010057)1.94733430
79Abnormality of chromosome stability (HP:0003220)1.93423676
80Cleft eyelid (HP:0000625)1.93197547
81Hydroureter (HP:0000072)1.93188149
82Ankle contracture (HP:0006466)1.93092281
83Meckel diverticulum (HP:0002245)1.92812919
84Congenital sensorineural hearing impairment (HP:0008527)1.90703835
85Abnormality of the anterior chamber (HP:0000593)1.89693850
86Increased circulating renin level (HP:0000848)1.89268489
87Limb hypertonia (HP:0002509)1.88986698
88Subcapsular cataract (HP:0000523)1.86778707
89Hypercortisolism (HP:0001578)1.85895224
90Duodenal stenosis (HP:0100867)1.83758462
91Small intestinal stenosis (HP:0012848)1.83758462
92Nephroblastoma (Wilms tumor) (HP:0002667)1.83663837
93Abnormality of the ileum (HP:0001549)1.81979064
94Microglossia (HP:0000171)1.81644289
95Abnormal ciliary motility (HP:0012262)1.75618019
96Absent radius (HP:0003974)1.74777144
97Diminished movement (HP:0002374)1.74575077
98Abnormal biliary tract physiology (HP:0012439)1.74273476
99Bile duct proliferation (HP:0001408)1.74273476
100Hypohidrosis (HP:0000966)1.73242390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.15420742
2ARAF5.58529148
3MAP3K135.25784139
4NEK63.26863725
5TTK3.13122129
6STK242.81728175
7BRAF2.78122661
8CDK122.65587658
9TAOK32.55408233
10MET2.54683524
11BUB12.52172165
12CDK92.44225579
13AURKA2.42261395
14MOS2.26039180
15CDC72.17753897
16KSR22.04206467
17RAF11.96988207
18PRKCI1.71064073
19TRIM281.68506326
20CDK71.60755967
21EIF2AK31.55179518
22MELK1.54026338
23PLK11.52790040
24NTRK21.41408155
25BRSK11.40008277
26STK31.22763257
27KSR11.22316256
28SRPK11.08253192
29MAP3K81.07892450
30ZAK1.06238313
31TNIK1.03261262
32NEK21.02796881
33PBK0.99648103
34CHEK10.98094345
35CDK190.97344582
36PTK20.95186527
37CDK80.94076646
38TESK20.93780197
39AURKB0.93525150
40PIM10.91350454
41PLK30.89004660
42CSNK1G10.80209125
43CHEK20.79920663
44CDK20.76470481
45NME10.75115185
46MST40.74497855
47MAPKAPK30.74224302
48MARK30.74020947
49BRSK20.72982834
50WNK10.70403704
51PAK10.70167208
52DMPK0.66399153
53NUAK10.63601273
54NEK90.63307520
55EEF2K0.62828039
56LATS20.61734561
57NTRK30.60660715
58CSNK1G30.57902579
59CDK10.57447528
60ATM0.56808377
61TIE10.55189613
62ATR0.55070701
63MTOR0.54327568
64CSNK1D0.54183022
65LRRK20.51403212
66TNK20.49928817
67CSNK1E0.46457686
68BMPR1B0.46245631
69TGFBR10.43820025
70PRKG10.43094905
71STK390.42491694
72MAP3K50.41861465
73CSNK1A1L0.41650509
74FLT30.39938158
75PKN10.39643769
76VRK10.37577426
77MAPK130.35646558
78RPS6KB20.34066801
79PRKCZ0.32073429
80CAMK1D0.29719025
81TLK10.28803711
82AKT20.28232569
83STK40.28013078
84CAMK2A0.27980318
85CSNK1G20.27338671
86CLK10.26583705
87GSK3B0.25215796
88CDK50.23795011
89PRKACB0.22906015
90MAPK10.21234700
91PDK10.20115877
92MAPK110.19650420
93PRKACA0.18007818
94CHUK0.16885452
95MAPK100.16387114
96STK160.15955600
97BRD40.15189531
98CSNK2A20.12829709
99MAP3K10.12533075
100PLK40.12416137

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.23994899
2Cell cycle_Homo sapiens_hsa041104.66393833
3Mismatch repair_Homo sapiens_hsa034304.07197779
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.65550040
5Oocyte meiosis_Homo sapiens_hsa041143.45515861
6Ovarian steroidogenesis_Homo sapiens_hsa049133.42685689
7Base excision repair_Homo sapiens_hsa034103.13717546
8DNA replication_Homo sapiens_hsa030302.85984451
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.61660933
10RNA degradation_Homo sapiens_hsa030182.61226624
11Caffeine metabolism_Homo sapiens_hsa002322.49915200
12Nucleotide excision repair_Homo sapiens_hsa034202.45941700
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32177904
14Homologous recombination_Homo sapiens_hsa034402.31292302
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.28963149
16Fanconi anemia pathway_Homo sapiens_hsa034602.26999809
17RNA transport_Homo sapiens_hsa030132.20058680
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16083690
19Folate biosynthesis_Homo sapiens_hsa007902.13091522
20Dorso-ventral axis formation_Homo sapiens_hsa043202.07716417
21p53 signaling pathway_Homo sapiens_hsa041151.92408707
22RNA polymerase_Homo sapiens_hsa030201.72033233
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61805699
24Olfactory transduction_Homo sapiens_hsa047401.58492006
25Circadian rhythm_Homo sapiens_hsa047101.49064672
26mRNA surveillance pathway_Homo sapiens_hsa030151.42615901
27Thyroid cancer_Homo sapiens_hsa052161.41023427
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38870589
29Gap junction_Homo sapiens_hsa045401.38172879
30Fatty acid elongation_Homo sapiens_hsa000621.24283369
31Proteasome_Homo sapiens_hsa030500.95829875
32Inositol phosphate metabolism_Homo sapiens_hsa005620.93256925
33Phototransduction_Homo sapiens_hsa047440.87173703
34ABC transporters_Homo sapiens_hsa020100.83261334
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78429553
36Purine metabolism_Homo sapiens_hsa002300.75884668
37Spliceosome_Homo sapiens_hsa030400.73767885
38Taste transduction_Homo sapiens_hsa047420.69264596
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66427295
40TGF-beta signaling pathway_Homo sapiens_hsa043500.65385444
41Bile secretion_Homo sapiens_hsa049760.62074436
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61528270
43Pyrimidine metabolism_Homo sapiens_hsa002400.60768900
44mTOR signaling pathway_Homo sapiens_hsa041500.60559778
45Huntingtons disease_Homo sapiens_hsa050160.58923936
46MicroRNAs in cancer_Homo sapiens_hsa052060.57363084
47Viral carcinogenesis_Homo sapiens_hsa052030.56475039
48Synaptic vesicle cycle_Homo sapiens_hsa047210.55443362
49Adherens junction_Homo sapiens_hsa045200.52559146
50Vitamin digestion and absorption_Homo sapiens_hsa049770.51705580
51Nicotine addiction_Homo sapiens_hsa050330.51134759
52Morphine addiction_Homo sapiens_hsa050320.49027767
53GABAergic synapse_Homo sapiens_hsa047270.48108870
54FoxO signaling pathway_Homo sapiens_hsa040680.46727210
55Arginine biosynthesis_Homo sapiens_hsa002200.45916513
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45775199
57Regulation of autophagy_Homo sapiens_hsa041400.45205020
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.43569628
59Small cell lung cancer_Homo sapiens_hsa052220.40773214
60Herpes simplex infection_Homo sapiens_hsa051680.38414232
61HTLV-I infection_Homo sapiens_hsa051660.31618050
62Wnt signaling pathway_Homo sapiens_hsa043100.31437350
63Long-term depression_Homo sapiens_hsa047300.29436190
64Hippo signaling pathway_Homo sapiens_hsa043900.27138521
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26171209
66Serotonergic synapse_Homo sapiens_hsa047260.25799388
67Arginine and proline metabolism_Homo sapiens_hsa003300.25232399
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22503345
69Non-homologous end-joining_Homo sapiens_hsa034500.22290062
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21826065
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21421008
72ErbB signaling pathway_Homo sapiens_hsa040120.21164724
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.20792735
74Ribosome_Homo sapiens_hsa030100.19369111
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19144542
76Epstein-Barr virus infection_Homo sapiens_hsa051690.15725218
77Renal cell carcinoma_Homo sapiens_hsa052110.10570038
78Endometrial cancer_Homo sapiens_hsa052130.10005334
79Phagosome_Homo sapiens_hsa041450.09583904
80Pyruvate metabolism_Homo sapiens_hsa006200.08654160
81Lysine degradation_Homo sapiens_hsa003100.08418156
82Ras signaling pathway_Homo sapiens_hsa040140.08199426
83Notch signaling pathway_Homo sapiens_hsa043300.08149580
84Metabolic pathways_Homo sapiens_hsa011000.07320184
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05227632
86Hepatitis B_Homo sapiens_hsa051610.04994318
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04788023
88Propanoate metabolism_Homo sapiens_hsa006400.04556049
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.04175134
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04126176
91Insulin signaling pathway_Homo sapiens_hsa049100.02696787
92Pathways in cancer_Homo sapiens_hsa052000.02023878
93HIF-1 signaling pathway_Homo sapiens_hsa040660.01947313
94Prostate cancer_Homo sapiens_hsa052150.01545324
95Tight junction_Homo sapiens_hsa045300.01348595
96Oxytocin signaling pathway_Homo sapiens_hsa049210.01246646
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.00566510
98Cardiac muscle contraction_Homo sapiens_hsa042600.00341104
99Protein digestion and absorption_Homo sapiens_hsa04974-2.2377468
100Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0021516

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