ACTL7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.75043493
2spermatid development (GO:0007286)9.60443201
3epithelial cilium movement (GO:0003351)9.45317383
4cilium or flagellum-dependent cell motility (GO:0001539)9.34237673
5motile cilium assembly (GO:0044458)9.22743119
6reproduction (GO:0000003)8.72830312
7response to pheromone (GO:0019236)8.60395620
8regulation of cilium movement (GO:0003352)8.12643240
9cilium movement (GO:0003341)7.76629736
10piRNA metabolic process (GO:0034587)7.53549865
11synaptonemal complex organization (GO:0070193)7.42586056
12male meiosis (GO:0007140)7.29233295
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.27321444
14synaptonemal complex assembly (GO:0007130)7.26230014
15single fertilization (GO:0007338)7.14935634
16rRNA methylation (GO:0031167)7.06961429
17phosphatidylethanolamine biosynthetic process (GO:0006646)6.85603256
18spermatogenesis (GO:0007283)6.73155492
19sperm capacitation (GO:0048240)6.72565997
20organic cation transport (GO:0015695)6.71194805
21male gamete generation (GO:0048232)6.70719939
22negative regulation of inclusion body assembly (GO:0090084)6.45723149
23phosphatidylethanolamine metabolic process (GO:0046337)6.32333648
24fertilization (GO:0009566)6.27518636
25gamete generation (GO:0007276)6.15622628
26protein targeting to Golgi (GO:0000042)6.09885296
27cellular ketone body metabolic process (GO:0046950)6.05766631
28rRNA modification (GO:0000154)5.94476028
29establishment of protein localization to Golgi (GO:0072600)5.85088854
30microtubule depolymerization (GO:0007019)5.76132372
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68369795
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.61777026
33regulation of inclusion body assembly (GO:0090083)5.55063392
34germ cell development (GO:0007281)5.46808353
35calcium ion-dependent exocytosis (GO:0017156)5.43537981
36seminiferous tubule development (GO:0072520)5.35352199
37ketone body metabolic process (GO:1902224)5.34665492
38ventricular system development (GO:0021591)5.23399364
39male meiosis I (GO:0007141)5.20151809
40sequestering of actin monomers (GO:0042989)5.15231594
41chromosome condensation (GO:0030261)5.12172217
42cell recognition (GO:0008037)5.08035093
43DNA packaging (GO:0006323)5.04007357
44microtubule severing (GO:0051013)4.96139676
45DNA methylation involved in gamete generation (GO:0043046)4.95777803
46positive regulation of Rab GTPase activity (GO:0032851)4.90784378
47regulation of Rab GTPase activity (GO:0032313)4.90784378
48chromosome organization involved in meiosis (GO:0070192)4.88970804
49centriole replication (GO:0007099)4.87877181
50regulation of microtubule-based movement (GO:0060632)4.82870135
51multicellular organismal reproductive process (GO:0048609)4.82648828
52chromatin silencing (GO:0006342)4.70051068
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69392371
54regulation of transcription involved in cell fate commitment (GO:0060850)4.51783431
55left/right pattern formation (GO:0060972)4.47270366
56meiotic nuclear division (GO:0007126)4.41705846
57centriole assembly (GO:0098534)4.41346244
58protein localization to Golgi apparatus (GO:0034067)4.35782217
59glycerol ether metabolic process (GO:0006662)4.22505036
60meiosis I (GO:0007127)4.18634518
61spermatid nucleus differentiation (GO:0007289)3.95418040
62genitalia morphogenesis (GO:0035112)3.91381606
63ether metabolic process (GO:0018904)3.89822040
64multicellular organismal development (GO:0007275)3.89167258
65chaperone-mediated protein complex assembly (GO:0051131)3.88093801
66coenzyme catabolic process (GO:0009109)3.88004490
67response to acidic pH (GO:0010447)3.83699277
68protein localization to cilium (GO:0061512)3.83662439
69regulation of centriole replication (GO:0046599)3.79332417
70protein polyglutamylation (GO:0018095)3.73983729
71monoubiquitinated protein deubiquitination (GO:0035520)3.63368876
72peptidyl-threonine dephosphorylation (GO:0035970)3.61975933
73negative regulation of Rho protein signal transduction (GO:0035024)3.59934391
74meiotic cell cycle (GO:0051321)3.59237003
75cellular response to pH (GO:0071467)3.52161894
76RNA localization (GO:0006403)3.48102888
77carnitine transport (GO:0015879)3.47712924
78amino-acid betaine transport (GO:0015838)3.47712924
79musculoskeletal movement (GO:0050881)3.44897581
80multicellular organismal movement (GO:0050879)3.44897581
81regulation of spindle checkpoint (GO:0090231)3.44654091
82interferon-gamma secretion (GO:0072643)3.40155967
83membrane protein intracellular domain proteolysis (GO:0031293)3.38555018
84cerebral cortex neuron differentiation (GO:0021895)3.35840907
85carnitine transmembrane transport (GO:1902603)3.35277385
86RNA destabilization (GO:0050779)3.33731659
87positive regulation of macrophage activation (GO:0043032)3.31848055
88regulation of interleukin-13 production (GO:0032656)3.25577289
89histone H3-K9 demethylation (GO:0033169)3.24015905
90homeostasis of number of cells within a tissue (GO:0048873)3.23610212
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22186081
92negative regulation of gene expression, epigenetic (GO:0045814)3.19796547
93regulation of T-helper 2 cell differentiation (GO:0045628)3.15455638
94protein depolymerization (GO:0051261)3.13990330
95axoneme assembly (GO:0035082)3.12653528
96negative regulation of organelle assembly (GO:1902116)3.12130009
97protein refolding (GO:0042026)3.11632906
98cranial nerve morphogenesis (GO:0021602)3.10849938
99sexual reproduction (GO:0019953)3.08897715
100single strand break repair (GO:0000012)3.04356642
101protein K11-linked deubiquitination (GO:0035871)3.02896003
102nucleus organization (GO:0006997)3.02294703
103DNA conformation change (GO:0071103)2.98247445
104mitotic sister chromatid cohesion (GO:0007064)2.97162257
105regulation of phosphoprotein phosphatase activity (GO:0043666)2.96690026
106lactate metabolic process (GO:0006089)2.95513715
107regulation of somitogenesis (GO:0014807)2.94497998
108intraciliary transport (GO:0042073)2.91659938
109microtubule polymerization or depolymerization (GO:0031109)2.90864140
110meiotic cell cycle process (GO:1903046)2.89000493
111mesenchymal cell differentiation involved in kidney development (GO:0072161)2.88958413
112mesenchymal cell differentiation involved in renal system development (GO:2001012)2.88958413
113nucleoside diphosphate phosphorylation (GO:0006165)2.87334519
114polyol catabolic process (GO:0046174)2.85560732
115negative regulation of histone methylation (GO:0031061)2.84173369
116glomerular visceral epithelial cell development (GO:0072015)2.81521351
117microtubule-based movement (GO:0007018)2.81145274
118synapsis (GO:0007129)2.79440106
119cilium organization (GO:0044782)2.79125580
120glomerular epithelial cell development (GO:0072310)2.77508402
121glycolytic process (GO:0006096)2.77288150
122cilium morphogenesis (GO:0060271)2.76732538
123mitochondrial fission (GO:0000266)2.75307196
124cell differentiation involved in metanephros development (GO:0072202)2.75014119
125microtubule nucleation (GO:0007020)2.74407702
126nucleosome disassembly (GO:0006337)2.73855075
127protein-DNA complex disassembly (GO:0032986)2.73855075
128alditol metabolic process (GO:0019400)2.73246798
129histone exchange (GO:0043486)2.73192000
130positive regulation of endothelial cell differentiation (GO:0045603)2.71348656
131peptidyl-glutamic acid modification (GO:0018200)2.70248866
132cellular component assembly involved in morphogenesis (GO:0010927)2.69686915
133polyamine biosynthetic process (GO:0006596)2.66441018
134regulation of cilium assembly (GO:1902017)2.64367634
135gene silencing by RNA (GO:0031047)2.64229596
136lipid translocation (GO:0034204)2.63999357
137phospholipid translocation (GO:0045332)2.63999357
138cilium assembly (GO:0042384)2.63316798
139fusion of sperm to egg plasma membrane (GO:0007342)13.3620073
140sperm motility (GO:0030317)13.0323740
141cell wall macromolecule metabolic process (GO:0044036)12.6410934
142cell wall macromolecule catabolic process (GO:0016998)12.6410934
143acrosome reaction (GO:0007340)12.1122465
144acrosome assembly (GO:0001675)11.8794551
145sperm-egg recognition (GO:0035036)11.7304448
146binding of sperm to zona pellucida (GO:0007339)10.8821165
147cell-cell recognition (GO:0009988)10.4938555
148multicellular organism reproduction (GO:0032504)10.3395391
149plasma membrane fusion (GO:0045026)10.1775622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56469159
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94752372
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.65478566
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47612583
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.09319648
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.05710018
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98535992
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41056835
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35325322
10ZNF274_21170338_ChIP-Seq_K562_Hela2.21486239
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.18492011
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.14175361
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07816658
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5082208
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97010878
16ERA_21632823_ChIP-Seq_H3396_Human1.94544097
17NANOG_20526341_ChIP-Seq_ESCs_Human1.91315025
18RAC3_21632823_ChIP-Seq_H3396_Human1.90170767
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89298984
20CTCF_27219007_Chip-Seq_Bcells_Human1.89292876
21DROSHA_22980978_ChIP-Seq_HELA_Human1.89197628
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87122456
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.86653255
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86399220
25VDR_22108803_ChIP-Seq_LS180_Human1.82023735
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.80329014
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79997748
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77102578
29BCL6_27268052_Chip-Seq_Bcells_Human1.75413642
30FUS_26573619_Chip-Seq_HEK293_Human1.71852121
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.71198194
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70551820
33E2F1_20622854_ChIP-Seq_HELA_Human1.66916473
34SMC4_20622854_ChIP-Seq_HELA_Human1.66780738
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66569422
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65211191
37STAT1_17558387_ChIP-Seq_HELA_Human1.63312454
38TAF2_19829295_ChIP-Seq_ESCs_Human1.62738109
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59981662
40P68_20966046_ChIP-Seq_HELA_Human1.59813939
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58375214
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.55722479
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53155609
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53036853
45TP63_22573176_ChIP-Seq_HFKS_Human1.52473410
46OCT4_20526341_ChIP-Seq_ESCs_Human1.51704939
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48895014
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.48806152
49* GATA3_21867929_ChIP-Seq_CD8_Mouse1.47260827
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46978418
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.46111241
52ER_23166858_ChIP-Seq_MCF-7_Human1.45436178
53CBP_20019798_ChIP-Seq_JUKART_Human1.44398518
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44398518
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42869756
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42702782
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42294263
58P300_27268052_Chip-Seq_Bcells_Human1.41795459
59* LXR_22292898_ChIP-Seq_THP-1_Human1.41393888
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.41010075
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39992146
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39814052
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38289070
64P53_21459846_ChIP-Seq_SAOS-2_Human1.36746152
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.35491461
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34880227
67RBPJ_21746931_ChIP-Seq_IB4_Human1.34867908
68P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.34837350
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34367009
70LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33806737
71CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33018798
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32927591
73CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32361177
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.31385561
75* AR_25329375_ChIP-Seq_VCAP_Human1.30788501
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30528941
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30459848
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.28915677
79ETV1_20927104_ChIP-Seq_GIST48_Human1.27081302
80REST_21632747_ChIP-Seq_MESCs_Mouse1.26907680
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26776200
82KDM2B_26808549_Chip-Seq_REH_Human1.25734051
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.24427369
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24334023
85CEBPB_22108803_ChIP-Seq_LS180_Human1.21333035
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.20531314
87RUNX_20019798_ChIP-Seq_JUKART_Human1.20427034
88SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19698907
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.19367180
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19343086
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19302154
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17578498
93NFYB_21822215_ChIP-Seq_K562_Human1.16968136
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16267914
95TBL1_22424771_ChIP-Seq_293T_Human1.15348189
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15137668
97SMRT_27268052_Chip-Seq_Bcells_Human1.14780949
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.14151404
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.13999598
100ERG_20517297_ChIP-Seq_VCAP_Human1.13325992
101GF1_26923725_Chip-Seq_HPCs_Mouse1.13270167
102P300_19829295_ChIP-Seq_ESCs_Human1.12897284
103CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12335585
104SA1_27219007_Chip-Seq_Bcells_Human1.12274864
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11536444
106GATA3_21867929_ChIP-Seq_TH1_Mouse1.11361436
107TAF15_26573619_Chip-Seq_HEK293_Human1.11027781
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10834861
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.10105757
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.09685114
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09272717
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08338141
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.08274485
114PHF8_20622853_ChIP-Seq_HELA_Human1.07963954
115GATA6_21074721_ChIP-Seq_CACO-2_Human1.07261595
116EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07188924
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07030588
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07030588
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06963706
120* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06864930
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06479722
122MYC_27129775_Chip-Seq_CORNEA_Mouse1.06427504
123RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06310757
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.06072915
125* TP53_18474530_ChIP-ChIP_U2OS_Human1.05919359
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05773087
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04919773
128OCT1_27270436_Chip-Seq_PROSTATE_Human1.04495389
129CTCF_20526341_ChIP-Seq_ESCs_Human1.04000018
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.03634365
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.03507472
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03479393
133CSB_26484114_Chip-Seq_FIBROBLAST_Human1.02639525
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02201817
135SPI1_26923725_Chip-Seq_HPCs_Mouse1.01413505
136SA1_27219007_Chip-Seq_ERYTHROID_Human1.00350348
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00349967
138ESET_19884257_ChIP-Seq_ESCs_Mouse1.00300666
139NFYA_21822215_ChIP-Seq_K562_Human0.99897666
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.99617368
141LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98788799
142RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98590396
143OCT4_19829295_ChIP-Seq_ESCs_Human0.97684543
144* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97531721
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97304462
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97225064
147KLF4_19829295_ChIP-Seq_ESCs_Human0.96915221
148SMAD4_21799915_ChIP-Seq_A2780_Human0.96561269
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.95668885
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95319627
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94928909
152SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94240746
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93224077
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93039982
155SOX2_21211035_ChIP-Seq_LN229_Human0.91766634
156FLI1_21867929_ChIP-Seq_CD8_Mouse0.90868809
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90588861
158RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90378837
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89702193
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89227069
161* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89123598
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87565927
163PHF8_20622854_ChIP-Seq_HELA_Human0.87087748
164BCOR_27268052_Chip-Seq_Bcells_Human0.85605667
165* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85541993
166TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83820944
167OCT4_18555785_Chip-Seq_ESCs_Mouse0.82404951
168MYC_19829295_ChIP-Seq_ESCs_Human0.81277815
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81054729
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80942196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.94308833
2MP0001929_abnormal_gametogenesis5.46503973
3MP0008877_abnormal_DNA_methylation4.00981926
4MP0002210_abnormal_sex_determination3.33892739
5MP0001348_abnormal_lacrimal_gland3.21588669
6MP0002161_abnormal_fertility/fecundity3.20179585
7MP0001145_abnormal_male_reproductive2.89861947
8MP0005670_abnormal_white_adipose2.57482612
9MP0000678_abnormal_parathyroid_gland2.54062325
10MP0000653_abnormal_sex_gland2.50632888
11MP0003718_maternal_effect2.37839696
12MP0002160_abnormal_reproductive_system2.37590917
13MP0003646_muscle_fatigue2.13527074
14MP0002653_abnormal_ependyma_morphology2.07280121
15MP0002132_abnormal_respiratory_system2.03504751
16MP0005410_abnormal_fertilization16.5565278
17MP0004233_abnormal_muscle_weight1.61877922
18MP0005423_abnormal_somatic_nervous1.61756454
19MP0002249_abnormal_larynx_morphology1.58375813
20MP0005379_endocrine/exocrine_gland_phen1.44186472
21MP0001485_abnormal_pinna_reflex1.36212149
22MP0009053_abnormal_anal_canal1.35363669
23MP0005310_abnormal_salivary_gland1.30259492
24MP0005623_abnormal_meninges_morphology1.29739416
25MP0001486_abnormal_startle_reflex1.28417299
26MP0002822_catalepsy1.26292279
27MP0004510_myositis1.23809814
28MP0002138_abnormal_hepatobiliary_system1.19623927
29MP0005389_reproductive_system_phenotype1.19066798
30MP0004859_abnormal_synaptic_plasticity1.17817460
31MP0002735_abnormal_chemical_nociception1.17262553
32MP0002127_abnormal_cardiovascular_syste1.09933886
33MP0005395_other_phenotype1.08594816
34MP0001968_abnormal_touch/_nociception1.07201607
35MP0004742_abnormal_vestibular_system1.06310096
36MP0001963_abnormal_hearing_physiology1.02072942
37MP0005248_abnormal_Harderian_gland1.01379280
38MP0002282_abnormal_trachea_morphology1.00440178
39MP0001765_abnormal_ion_homeostasis0.95146201
40MP0001984_abnormal_olfaction0.94346472
41MP0000026_abnormal_inner_ear0.91839295
42MP0005647_abnormal_sex_gland0.89601711
43MP0005451_abnormal_body_composition0.86016458
44MP0000681_abnormal_thyroid_gland0.82409147
45MP0000955_abnormal_spinal_cord0.81404881
46MP0008569_lethality_at_weaning0.80986400
47MP0003115_abnormal_respiratory_system0.78769625
48MP0000049_abnormal_middle_ear0.76925674
49MP0005083_abnormal_biliary_tract0.73796989
50MP0001879_abnormal_lymphatic_vessel0.72775018
51MP0002067_abnormal_sensory_capabilities0.72365587
52MP0008995_early_reproductive_senescence0.70728165
53MP0002234_abnormal_pharynx_morphology0.69041781
54MP0001905_abnormal_dopamine_level0.68122798
55MP0009046_muscle_twitch0.67883452
56MP0003011_delayed_dark_adaptation0.67825866
57MP0002557_abnormal_social/conspecific_i0.67728174
58MP0004085_abnormal_heartbeat0.66589465
59MP0002733_abnormal_thermal_nociception0.63136769
60MP0006036_abnormal_mitochondrial_physio0.61980128
61MP0000516_abnormal_urinary_system0.60987633
62MP0005367_renal/urinary_system_phenotyp0.60987633
63MP0003878_abnormal_ear_physiology0.60434463
64MP0005377_hearing/vestibular/ear_phenot0.60434463
65MP0008058_abnormal_DNA_repair0.60185698
66MP0005397_hematopoietic_system_phenotyp0.59727358
67MP0001545_abnormal_hematopoietic_system0.59727358
68MP0003329_amyloid_beta_deposits0.59276068
69MP0009278_abnormal_bone_marrow0.58636668
70MP0000358_abnormal_cell_content/0.57461806
71MP0001666_abnormal_nutrient_absorption0.55915881
72MP0004036_abnormal_muscle_relaxation0.55276232
73MP0005666_abnormal_adipose_tissue0.54163799
74MP0003077_abnormal_cell_cycle0.53584894
75MP0010094_abnormal_chromosome_stability0.53196153
76MP0004484_altered_response_of0.52378645
77MP0002272_abnormal_nervous_system0.51787941
78MP0002572_abnormal_emotion/affect_behav0.51427189
79MP0005636_abnormal_mineral_homeostasis0.50891679
80MP0003950_abnormal_plasma_membrane0.48744568
81MP0000003_abnormal_adipose_tissue0.47894983
82MP0003699_abnormal_female_reproductive0.47859203
83MP0001661_extended_life_span0.46988648
84MP0005167_abnormal_blood-brain_barrier0.46315736
85MP0002269_muscular_atrophy0.46300673
86MP0003119_abnormal_digestive_system0.45552774
87MP0001324_abnormal_eye_pigmentation0.44987374
88MP0008057_abnormal_DNA_replication0.44754433
89MP0009745_abnormal_behavioral_response0.44410561
90MP0000569_abnormal_digit_pigmentation0.43122792
91MP0001970_abnormal_pain_threshold0.43066172
92MP0001440_abnormal_grooming_behavior0.42760911
93MP0000613_abnormal_salivary_gland0.42523866
94MP0000534_abnormal_ureter_morphology0.42455244
95MP0002734_abnormal_mechanical_nocicepti0.42353141
96MP0008007_abnormal_cellular_replicative0.42100687
97MP0009697_abnormal_copulation0.41973333
98MP0000470_abnormal_stomach_morphology0.40878014
99MP0000249_abnormal_blood_vessel0.40737047
100MP0001293_anophthalmia0.39936906
101MP0006292_abnormal_olfactory_placode0.39907409
102MP0003137_abnormal_impulse_conducting0.39357720
103MP0005535_abnormal_body_temperature0.39195400
104MP0003091_abnormal_cell_migration0.38488145
105MP0000751_myopathy0.37671791
106MP0001501_abnormal_sleep_pattern0.37603789
107MP0002928_abnormal_bile_duct0.36820708
108MP0001270_distended_abdomen0.36396650
109MP0004811_abnormal_neuron_physiology0.36291784
110MP0003787_abnormal_imprinting0.36145625
111MP0003880_abnormal_central_pattern0.35864090
112MP0000566_synostosis0.35233406
113MP0001730_embryonic_growth_arrest0.34050392
114MP0003635_abnormal_synaptic_transmissio0.33602121
115MP0005253_abnormal_eye_physiology0.33137444
116MP0003786_premature_aging0.32916084
117MP0003111_abnormal_nucleus_morphology0.32797714
118MP0006035_abnormal_mitochondrial_morpho0.32659513
119MP0003632_abnormal_nervous_system0.32067412
120MP0003942_abnormal_urinary_system0.31544248
121MP0005551_abnormal_eye_electrophysiolog0.30813982
122MP0001764_abnormal_homeostasis0.29962732
123MP0009115_abnormal_fat_cell0.29703516
124MP0003879_abnormal_hair_cell0.29687300
125MP0000604_amyloidosis0.29593516
126MP0005391_vision/eye_phenotype0.28953685
127MP0002139_abnormal_hepatobiliary_system0.28694775
128MP0004133_heterotaxia0.28462818
129MP0001727_abnormal_embryo_implantation0.27884447
130MP0004019_abnormal_vitamin_homeostasis0.27851847
131MP0008961_abnormal_basal_metabolism0.27435855
132MP0004270_analgesia0.26444030
133MP0003861_abnormal_nervous_system0.26250020
134MP0003633_abnormal_nervous_system0.25407120
135MP0002152_abnormal_brain_morphology0.24651439
136MP0000749_muscle_degeneration0.24290522
137MP0004808_abnormal_hematopoietic_stem0.23722157
138MP0003948_abnormal_gas_homeostasis0.23576420
139MP0010307_abnormal_tumor_latency0.22903689
140MP0002295_abnormal_pulmonary_circulatio0.22685059
141MP0002971_abnormal_brown_adipose0.22647031
142MP0002909_abnormal_adrenal_gland0.22464636
143MP0002169_no_abnormal_phenotype0.21241442
144MP0002873_normal_phenotype0.21007960
145MP0002084_abnormal_developmental_patter0.20888021
146MP0000313_abnormal_cell_death0.20883908
147MP0003631_nervous_system_phenotype0.20837615
148MP0002736_abnormal_nociception_after0.20114448
149MP0003959_abnormal_lean_body0.20078497
150MP0003936_abnormal_reproductive_system0.19952191
151MP0001119_abnormal_female_reproductive0.19821460
152MP0002092_abnormal_eye_morphology0.19725199
153MP0003183_abnormal_peptide_metabolism0.19197343
154MP0001849_ear_inflammation0.18055439
155MP0005375_adipose_tissue_phenotype0.16802993
156MP0001697_abnormal_embryo_size0.15791248
157MP0003045_fibrosis0.15094922
158MP0002108_abnormal_muscle_morphology0.15032246
159MP0004087_abnormal_muscle_fiber0.14901768
160MP0008875_abnormal_xenobiotic_pharmacok0.13761563
161MP0000001_mammalian_phenotype0.13689221
162MP0002229_neurodegeneration0.13673919
163MP0004043_abnormal_pH_regulation0.13550006

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.24036189
2Abnormal respiratory motile cilium morphology (HP:0005938)8.94286685
3Abnormal respiratory epithelium morphology (HP:0012253)8.94286685
4Severe visual impairment (HP:0001141)8.62412386
5Rhinitis (HP:0012384)7.83678605
6Chronic bronchitis (HP:0004469)7.46245081
7Abnormal ciliary motility (HP:0012262)7.09225374
8Infertility (HP:0000789)7.03982094
9Nasal polyposis (HP:0100582)6.46173675
10Abnormality of the nasal mucosa (HP:0000433)5.32127562
11Bony spicule pigmentary retinopathy (HP:0007737)5.29269494
12Attenuation of retinal blood vessels (HP:0007843)5.22824459
13Resting tremor (HP:0002322)4.74027570
14Hyperkalemia (HP:0002153)4.64029193
15Nephronophthisis (HP:0000090)4.63665755
16Bronchitis (HP:0012387)4.52568710
17Bronchiectasis (HP:0002110)4.50031527
18Chronic hepatic failure (HP:0100626)4.45874146
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.36839602
20Abnormal rod and cone electroretinograms (HP:0008323)4.27790433
21Male infertility (HP:0003251)4.23463698
22Abnormality of macular pigmentation (HP:0008002)4.11148116
23Potter facies (HP:0002009)4.01541709
24Facial shape deformation (HP:0011334)4.01541709
25Hypoplastic ischia (HP:0003175)3.80986387
26Cone-rod dystrophy (HP:0000548)3.63222261
27Abnormal spermatogenesis (HP:0008669)3.54337551
28Enlarged epiphyses (HP:0010580)3.52704539
29Abnormality of the renal medulla (HP:0100957)3.46509279
30Abnormality of the ischium (HP:0003174)3.38994797
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.35244748
32Recurrent otitis media (HP:0000403)3.28631065
33Hypoplasia of the thymus (HP:0000778)3.23236203
34Unilateral renal agenesis (HP:0000122)3.17566928
35Recurrent sinusitis (HP:0011108)3.15489387
36Postural instability (HP:0002172)3.11569508
37Progressive sensorineural hearing impairment (HP:0000408)3.09287667
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.03651329
39Hypoalphalipoproteinemia (HP:0003233)2.99279074
40Tubular atrophy (HP:0000092)2.91321067
41Generalized aminoaciduria (HP:0002909)2.86797774
42Tubulointerstitial nephritis (HP:0001970)2.82216617
43Abnormality of the aortic arch (HP:0012303)2.81336306
44Abnormality of midbrain morphology (HP:0002418)2.74230295
45Molar tooth sign on MRI (HP:0002419)2.74230295
46Truncal obesity (HP:0001956)2.69050968
47Tubulointerstitial abnormality (HP:0001969)2.68372121
48Impulsivity (HP:0100710)2.68193168
49Gonadotropin excess (HP:0000837)2.67731827
50Abnormality of potassium homeostasis (HP:0011042)2.66078496
51Recurrent bronchitis (HP:0002837)2.56784462
52Azoospermia (HP:0000027)2.52216049
53Renovascular hypertension (HP:0100817)2.49398900
54Cholecystitis (HP:0001082)2.46412197
55Abnormal gallbladder physiology (HP:0012438)2.46412197
56Insulin-resistant diabetes mellitus (HP:0000831)2.46235126
57Menstrual irregularities (HP:0000858)2.46009124
58Progressive cerebellar ataxia (HP:0002073)2.41906206
59Tubulointerstitial fibrosis (HP:0005576)2.37838690
60Portal hypertension (HP:0001409)2.37379420
61Abnormality of the costochondral junction (HP:0000919)2.34834430
62Amelogenesis imperfecta (HP:0000705)2.33659659
63Medial flaring of the eyebrow (HP:0010747)2.31830730
64Flattened epiphyses (HP:0003071)2.30346116
65Abnormality of the parathyroid morphology (HP:0011766)2.29958912
66Abnormality of dental color (HP:0011073)2.20245760
67Epiphyseal dysplasia (HP:0002656)2.19293333
68Abnormality of the lower motor neuron (HP:0002366)2.18921232
69Osteomalacia (HP:0002749)2.18905113
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17757467
71Abnormality of the hepatic vasculature (HP:0006707)2.16861203
72Dyschromatopsia (HP:0007641)2.15227814
73Polydipsia (HP:0001959)2.08476406
74Abnormal drinking behavior (HP:0030082)2.08476406
75Ventricular tachycardia (HP:0004756)2.08427144
76Choroideremia (HP:0001139)2.08072395
77Myokymia (HP:0002411)2.07985047
78Tetany (HP:0001281)2.06234394
79Abnormality of the epiphysis of the femoral head (HP:0010574)2.03481166
80Stage 5 chronic kidney disease (HP:0003774)2.00396244
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0710025
82Dynein arm defect of respiratory motile cilia (HP:0012255)12.9221290
83Absent/shortened dynein arms (HP:0200106)12.9221290
84Hyponatremia (HP:0002902)1.99705890
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98450223
86Hypophosphatemic rickets (HP:0004912)1.98361200
87Widely patent fontanelles and sutures (HP:0004492)1.96076637
88Progressive hearing impairment (HP:0001730)1.95900024
89Recurrent pneumonia (HP:0006532)1.94663006
90Abnormality of the pubic bones (HP:0003172)1.92329103
91Increased purine levels (HP:0004368)1.91089328
92Hyperuricemia (HP:0002149)1.91089328
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89697159
94Abnormality of femoral epiphyses (HP:0006499)1.89697159
95Transposition of the great arteries (HP:0001669)1.89468718
96Abnormal connection of the cardiac segments (HP:0011545)1.89468718
97Abnormal ventriculo-arterial connection (HP:0011563)1.89468718
98Spastic tetraparesis (HP:0001285)1.87848081
99Optic nerve hypoplasia (HP:0000609)1.87497546
100Peripheral hypomyelination (HP:0007182)1.87074178
101Postaxial foot polydactyly (HP:0001830)1.86194770
102Flat capital femoral epiphysis (HP:0003370)1.84723002
103Abnormality of the renal cortex (HP:0011035)1.83433727
104Hyperthyroidism (HP:0000836)1.82399447
105Abnormality of renal excretion (HP:0011036)1.82088834
106Abnormality of the femoral head (HP:0003368)1.80256517
107Recurrent corneal erosions (HP:0000495)1.79134059
108Amyotrophic lateral sclerosis (HP:0007354)1.77633757
109Renal Fanconi syndrome (HP:0001994)1.76224838
110Hypoparathyroidism (HP:0000829)1.75918445
111Congenital hepatic fibrosis (HP:0002612)1.75144913
112Heterotopia (HP:0002282)1.73027352
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72097859
114Absent epiphyses (HP:0010577)1.72097859
115Fibular hypoplasia (HP:0003038)1.71479753
116Decreased central vision (HP:0007663)1.67089599
117Short ribs (HP:0000773)1.66883493
118Oculomotor apraxia (HP:0000657)1.66101518
119Hemorrhage of the eye (HP:0011885)1.63960572
120Congenital malformation of the right heart (HP:0011723)1.63704851
121Double outlet right ventricle (HP:0001719)1.63704851
122Renal dysplasia (HP:0000110)1.63056482
123Bell-shaped thorax (HP:0001591)1.60352360
124Neurofibrillary tangles (HP:0002185)1.59434566
125Abnormality of permanent molar morphology (HP:0011071)1.59023747
126Abnormality of the dental root (HP:0006486)1.59023747
127Taurodontia (HP:0000679)1.59023747
128Impaired proprioception (HP:0010831)1.58023028
129Abnormality of dentin (HP:0010299)1.54987346
130Absent frontal sinuses (HP:0002688)1.51176539
131Abnormal urine output (HP:0012590)1.51022199
132Abnormality of molar morphology (HP:0011070)1.46250383
133Abnormality of molar (HP:0011077)1.46250383
134Abnormality of the dental pulp (HP:0006479)1.45586565
135Postaxial hand polydactyly (HP:0001162)1.43083290
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.41689566
137J-shaped sella turcica (HP:0002680)1.40804200
138Deformed sella turcica (HP:0002681)1.38684911
139Short femoral neck (HP:0100864)1.38201408
140Broad distal phalanx of finger (HP:0009836)1.35153655
141Loss of speech (HP:0002371)1.32742732
142Aplasia/Hypoplasia of the lens (HP:0008063)1.32596983
143Cerebral inclusion bodies (HP:0100314)1.32045640
144Cerebellar dysplasia (HP:0007033)1.31205994
145Abnormal biliary tract physiology (HP:0012439)1.30703076
146Bile duct proliferation (HP:0001408)1.30703076
147Polyuria (HP:0000103)1.30689541
148Nephropathy (HP:0000112)1.30441871
149Facial cleft (HP:0002006)1.29193777
150Microglossia (HP:0000171)1.28939205
151Difficulty climbing stairs (HP:0003551)1.28221917
152Short thorax (HP:0010306)1.27614986
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27023516
154Asymmetric septal hypertrophy (HP:0001670)1.25472929
155Hemiparesis (HP:0001269)1.23969659
156Cystic liver disease (HP:0006706)1.23481134
157Exercise-induced myalgia (HP:0003738)1.22110669
158Chronic sinusitis (HP:0011109)1.21182375
159Myoglobinuria (HP:0002913)1.21178840
160Easy fatigability (HP:0003388)1.20929945
161Abnormality of the neuromuscular junction (HP:0003398)1.18849664
162Fatigable weakness (HP:0003473)1.18849664
163Delayed gross motor development (HP:0002194)1.17593171
164Short nail (HP:0001799)1.16511183
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.16146534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.72656354
2PDK37.40027450
3PDK47.40027450
4PRKD35.40621903
5DDR25.05761155
6PDK24.76529060
7ICK4.73551908
8MAP4K23.69136873
9INSRR3.18923817
10BRD42.77915936
11PLK22.75968847
12PTK2B2.66718263
13STK382.23144390
14WNK42.15055242
15STK392.07806907
16NEK22.03176385
17PNCK2.00393293
18MST1R1.93234543
19PIK3CG1.41095518
20CDK121.40363553
21DYRK1B1.36150118
22MAP3K91.30712932
23CDK71.29141597
24KSR21.20052863
25PDK11.19643914
26TYRO30.98239817
27AKT30.91563691
28DYRK30.87689123
29EEF2K0.86674277
30WNK10.85579927
31MAPK150.84128518
32LATS20.84053638
33PASK0.83394591
34CAMK1D0.82913000
35PDPK10.79509511
36SIK20.77995499
37UHMK10.76891248
38IRAK10.72561735
39MAP3K110.70515053
40STK30.70253065
41TESK20.69806656
42RPS6KA20.69218013
43MAP3K20.68307629
44PINK10.67790641
45TTK0.65297039
46MAP2K20.64154140
47MAP3K80.63807362
48CCNB10.61233643
49ROCK10.60665801
50PRKAA20.57217167
51CAMK10.56195220
52CAMK1G0.54196698
53CHEK20.53884222
54CDK30.51465558
55IRAK20.51452830
56RIPK40.50745727
57LATS10.50729182
58ARAF0.49899131
59SGK4940.49341076
60SGK2230.49341076
61BMPR1B0.43526659
62MAP3K10.42840069
63MAP2K60.41439507
64MUSK0.41284464
65MAPK10.40919685
66NTRK20.37831016
67PAK10.37673121
68PAK20.36483056
69RPS6KL10.35325188
70RPS6KC10.35325188
71CAMK40.34250994
72CHEK10.34170534
73MET0.34017748
74LMTK20.33783406
75RPS6KA60.33614845
76MTOR0.33517773
77PRKCG0.33145184
78MARK10.32272571
79CAMKK10.30974333
80ATR0.29492161
81SGK10.29377889
82ATM0.28852144
83MARK20.28410060
84NTRK30.28159097
85MAP3K100.27641668
86PAK40.27119719
87PRKAA10.26799157
88RPS6KB10.25670880
89STK38L0.25570793
90MAPK140.24393857
91MAPK100.24377415
92NEK60.22390950
93WEE10.20598346
94MAPKAPK50.19495661
95CSF1R0.18493862
96MAPK110.17672482
97TIE10.16847272
98CDC70.16807056
99AKT10.16291107
100MINK10.15640107
101PRKCZ0.13562292
102MAP3K130.12921460
103TNIK0.11999665
104OXSR10.11845159
105TLK10.11373995
106FER0.11363775
107RPS6KA10.11334773
108PRKCQ0.10881516
109PLK10.10664573
110PAK60.10541830
111BRAF0.09287537
112TRIB30.09112449
113CDK150.08711999
114ACVR1B0.07870083
115BLK0.07530310
116ZAK0.07331662
117MAPK90.07278774
118IKBKB0.06386606
119CDK180.06280514
120PRKACG0.05413677
121CDK11A0.04971674
122CSNK1D0.04849915
123GSK3B0.04476152
124CSNK2A10.04366960
125PLK40.03675429
126CLK10.03564435
127CAMK2A0.03316847
128STK100.03243659
129STK110.03218396
130CDK140.02778007
131MAPK80.02515557
132CDK20.02297219
133PRKG10.01935363
134PIM10.01240905
135CDK10.01232415
136PRKCB0.01189075
137PKN10.01153671
138PRKG20.00972285
139MARK30.00766861
140CDK60.00748277
141PRKACA-0.0393741
142CDK4-0.0375248
143WNK3-0.0349678
144AURKA-0.0323094
145PRKACB-0.0312783
146MAP3K5-0.0302938
147PRKDC-0.0281795
148EGFR-0.0261016
149CSNK2A2-0.0258302
150MAP3K4-0.0251605
151BRSK2-0.0204603
152PRKCA-0.0164908
153RPS6KA3-0.0153117
154PRKCD-0.0141826
155BRSK1-0.0071871
156EPHB1-0.0060142

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.33996642
2Fatty acid biosynthesis_Homo sapiens_hsa000614.28965872
3Vitamin B6 metabolism_Homo sapiens_hsa007504.27399407
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.09677436
5Pyruvate metabolism_Homo sapiens_hsa006203.77469498
6Olfactory transduction_Homo sapiens_hsa047403.37624626
7Propanoate metabolism_Homo sapiens_hsa006403.04341007
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95177189
9Linoleic acid metabolism_Homo sapiens_hsa005912.84070970
10Butanoate metabolism_Homo sapiens_hsa006502.81097782
11Glucagon signaling pathway_Homo sapiens_hsa049222.79981482
12Selenocompound metabolism_Homo sapiens_hsa004502.47271306
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23845385
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.18502516
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15123545
16Basal transcription factors_Homo sapiens_hsa030222.04851361
17Glycerolipid metabolism_Homo sapiens_hsa005612.03183352
18PPAR signaling pathway_Homo sapiens_hsa033201.91868344
19Amphetamine addiction_Homo sapiens_hsa050311.90478498
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83305063
21Oocyte meiosis_Homo sapiens_hsa041141.72937447
22Pentose phosphate pathway_Homo sapiens_hsa000301.67374081
23Type I diabetes mellitus_Homo sapiens_hsa049401.60596179
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.60489851
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58931444
26Allograft rejection_Homo sapiens_hsa053301.56295542
27Autoimmune thyroid disease_Homo sapiens_hsa053201.52008976
28Fat digestion and absorption_Homo sapiens_hsa049751.49665396
29Cardiac muscle contraction_Homo sapiens_hsa042601.48858879
30Dorso-ventral axis formation_Homo sapiens_hsa043201.47645266
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.47450903
32Fructose and mannose metabolism_Homo sapiens_hsa000511.44206073
33Graft-versus-host disease_Homo sapiens_hsa053321.42038486
34Phenylalanine metabolism_Homo sapiens_hsa003601.40017763
35Fanconi anemia pathway_Homo sapiens_hsa034601.38033506
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.36911121
37Fatty acid metabolism_Homo sapiens_hsa012121.36846351
38Fatty acid degradation_Homo sapiens_hsa000711.33309035
39Carbon metabolism_Homo sapiens_hsa012001.30172954
40Renin secretion_Homo sapiens_hsa049241.29283237
41Ether lipid metabolism_Homo sapiens_hsa005651.29027834
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26554051
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20836279
44Glutathione metabolism_Homo sapiens_hsa004801.19965524
45Arginine and proline metabolism_Homo sapiens_hsa003301.17915870
46Systemic lupus erythematosus_Homo sapiens_hsa053221.15211614
47Huntingtons disease_Homo sapiens_hsa050161.12868054
48Viral myocarditis_Homo sapiens_hsa054161.08498625
49Mineral absorption_Homo sapiens_hsa049781.07756970
50mRNA surveillance pathway_Homo sapiens_hsa030151.04165010
51Long-term potentiation_Homo sapiens_hsa047201.02932486
52Phototransduction_Homo sapiens_hsa047441.00984629
53Arginine biosynthesis_Homo sapiens_hsa002200.92926036
54Antigen processing and presentation_Homo sapiens_hsa046120.90377523
55Morphine addiction_Homo sapiens_hsa050320.89994400
56Collecting duct acid secretion_Homo sapiens_hsa049660.86683321
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86229716
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.86196806
59Purine metabolism_Homo sapiens_hsa002300.84261084
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84238581
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82960630
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82625358
63RNA transport_Homo sapiens_hsa030130.81268667
64Hedgehog signaling pathway_Homo sapiens_hsa043400.78316111
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78202987
66Estrogen signaling pathway_Homo sapiens_hsa049150.77374733
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76901873
68Alcoholism_Homo sapiens_hsa050340.76332380
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75097665
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73072754
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72926009
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72431613
73Insulin secretion_Homo sapiens_hsa049110.72350863
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.70624898
75Influenza A_Homo sapiens_hsa051640.70151698
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67433696
77Biosynthesis of amino acids_Homo sapiens_hsa012300.66701343
78Arachidonic acid metabolism_Homo sapiens_hsa005900.65295514
79Chemical carcinogenesis_Homo sapiens_hsa052040.64647579
80Thyroid hormone synthesis_Homo sapiens_hsa049180.62374257
81AMPK signaling pathway_Homo sapiens_hsa041520.60237800
82Nicotine addiction_Homo sapiens_hsa050330.59704184
83Tyrosine metabolism_Homo sapiens_hsa003500.59534785
84Bile secretion_Homo sapiens_hsa049760.59361706
85VEGF signaling pathway_Homo sapiens_hsa043700.56137966
86ABC transporters_Homo sapiens_hsa020100.55711389
87Calcium signaling pathway_Homo sapiens_hsa040200.53532201
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52872494
89Glutamatergic synapse_Homo sapiens_hsa047240.49160563
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.48517825
91Retinol metabolism_Homo sapiens_hsa008300.48106954
92MAPK signaling pathway_Homo sapiens_hsa040100.47834195
93Tight junction_Homo sapiens_hsa045300.47324105
94Synaptic vesicle cycle_Homo sapiens_hsa047210.44917559
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.43969269
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.43680666
97Endocytosis_Homo sapiens_hsa041440.43405835
98Legionellosis_Homo sapiens_hsa051340.41707618
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41214093
100Serotonergic synapse_Homo sapiens_hsa047260.38010919
101Acute myeloid leukemia_Homo sapiens_hsa052210.37983640
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37933247
103Cocaine addiction_Homo sapiens_hsa050300.37032311
104Circadian entrainment_Homo sapiens_hsa047130.36677886
105Cholinergic synapse_Homo sapiens_hsa047250.36504404
106Renin-angiotensin system_Homo sapiens_hsa046140.35915993
107Pancreatic secretion_Homo sapiens_hsa049720.35678944
108Inositol phosphate metabolism_Homo sapiens_hsa005620.35424184
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35266540
110Salivary secretion_Homo sapiens_hsa049700.34965976
111cAMP signaling pathway_Homo sapiens_hsa040240.34599885
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32368134
113Nitrogen metabolism_Homo sapiens_hsa009100.32133432
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31247813
115Metabolic pathways_Homo sapiens_hsa011000.30796729
116GABAergic synapse_Homo sapiens_hsa047270.30479950
117B cell receptor signaling pathway_Homo sapiens_hsa046620.28334405
118Protein digestion and absorption_Homo sapiens_hsa049740.27866592
119Viral carcinogenesis_Homo sapiens_hsa052030.27645683
120Taste transduction_Homo sapiens_hsa047420.27073364
121Gastric acid secretion_Homo sapiens_hsa049710.26808086
122Oxytocin signaling pathway_Homo sapiens_hsa049210.26703678
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.21466831
124Insulin resistance_Homo sapiens_hsa049310.21091058
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19894247
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19794219
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18186606
128Sulfur metabolism_Homo sapiens_hsa009200.17669696
129Type II diabetes mellitus_Homo sapiens_hsa049300.17337748
130ECM-receptor interaction_Homo sapiens_hsa045120.17046579
131Prolactin signaling pathway_Homo sapiens_hsa049170.16364690
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15546264
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15141646
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15093716
135N-Glycan biosynthesis_Homo sapiens_hsa005100.14937310
136HIF-1 signaling pathway_Homo sapiens_hsa040660.14751457
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14650456
138Herpes simplex infection_Homo sapiens_hsa051680.14074812
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13213521
140Adherens junction_Homo sapiens_hsa045200.10814086

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