ACTBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sleep (GO:0030431)8.14710289
2tolerance induction (GO:0002507)7.57113614
3cellular response to interleukin-15 (GO:0071350)6.84466870
4negative regulation of cell killing (GO:0031342)5.35024770
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35024770
6response to interleukin-15 (GO:0070672)5.33842972
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.08836984
8regulation of T cell mediated cytotoxicity (GO:0001914)4.76524566
9RNA destabilization (GO:0050779)4.61909280
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.50959022
11positive regulation of T cell mediated cytotoxicity (GO:0001916)4.49916572
12positive regulation of defense response to virus by host (GO:0002230)4.48537770
13regulation of germinal center formation (GO:0002634)4.43901700
14DNA deamination (GO:0045006)4.40903283
15response to gravity (GO:0009629)4.40123611
16negative thymic T cell selection (GO:0045060)4.29758604
17regulation of memory T cell differentiation (GO:0043380)4.28531184
18mast cell activation (GO:0045576)4.27225570
19response to muramyl dipeptide (GO:0032495)4.26065337
20negative T cell selection (GO:0043383)4.25247776
21mast cell activation involved in immune response (GO:0002279)4.23111696
22mast cell degranulation (GO:0043303)4.23111696
23regulation of defense response to virus by host (GO:0050691)4.15592804
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.81789412
25T-helper cell differentiation (GO:0042093)3.81789412
26regulation of leukocyte mediated cytotoxicity (GO:0001910)3.79424291
27negative regulation of interleukin-1 beta production (GO:0032691)3.79038878
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69226031
29regulation of B cell receptor signaling pathway (GO:0050855)3.67753939
30adenosine metabolic process (GO:0046085)3.64850793
31positive regulation of T-helper 1 type immune response (GO:0002827)3.63943324
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.63404144
33regulation of gamma-delta T cell differentiation (GO:0045586)3.63363895
34negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.58279685
35negative regulation of interleukin-1 production (GO:0032692)3.56927015
36tumor necrosis factor-mediated signaling pathway (GO:0033209)3.56318210
37regulation of chronic inflammatory response (GO:0002676)3.54160872
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54142606
39T cell differentiation involved in immune response (GO:0002292)3.52050297
40alpha-beta T cell differentiation involved in immune response (GO:0002293)3.52050297
41alpha-beta T cell activation involved in immune response (GO:0002287)3.52050297
42positive regulation of T cell mediated immunity (GO:0002711)3.51678371
43positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.50872137
44regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.50872137
45negative regulation of bone resorption (GO:0045779)3.50845317
46regulation of T cell receptor signaling pathway (GO:0050856)3.50177192
47positive regulation of osteoclast differentiation (GO:0045672)3.46563740
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.43747030
49actin nucleation (GO:0045010)3.42811274
50protein K11-linked deubiquitination (GO:0035871)3.41544227
51germ cell migration (GO:0008354)3.40826220
52negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.40051052
53regulation of cell killing (GO:0031341)3.39981961
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34011156
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29259944
56regulation of T cell mediated immunity (GO:0002709)3.24226923
57positive thymic T cell selection (GO:0045059)3.21529260
58negative regulation of T cell receptor signaling pathway (GO:0050860)3.20900165
59positive regulation of mRNA catabolic process (GO:0061014)3.19900351
60regulation of T-helper 1 type immune response (GO:0002825)3.19193522
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15228028
62cellular response to exogenous dsRNA (GO:0071360)3.14500845
63cytidine metabolic process (GO:0046087)3.12514830
64cytidine catabolic process (GO:0006216)3.12514830
65cytidine deamination (GO:0009972)3.12514830
66lymph node development (GO:0048535)3.11038002
67positive regulation of cell killing (GO:0031343)3.07163345
68negative regulation of T cell mediated immunity (GO:0002710)3.06272630
69negative regulation of bone remodeling (GO:0046851)3.05940975
70leukocyte degranulation (GO:0043299)3.05211481
71regulation of gamma-delta T cell activation (GO:0046643)3.04220568
72alpha-beta T cell differentiation (GO:0046632)3.03208955
73preassembly of GPI anchor in ER membrane (GO:0016254)3.01110826
74regulation of alpha-beta T cell proliferation (GO:0046640)3.00688811
75negative regulation of T cell apoptotic process (GO:0070233)3.00467094
76positive regulation of prostaglandin secretion (GO:0032308)2.99764136
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98420723
78lysosome localization (GO:0032418)2.95679514
79mitotic cell cycle arrest (GO:0071850)2.95079056
80positive regulation of T cell differentiation in thymus (GO:0033089)2.94081749
81natural killer cell activation (GO:0030101)2.93906396
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93473859
83regulation of activation of Janus kinase activity (GO:0010533)2.91573130
84negative regulation of DNA-templated transcription, elongation (GO:0032785)2.90115827
85regulation of regulatory T cell differentiation (GO:0045589)2.88966436
86positive regulation of T cell cytokine production (GO:0002726)2.88261555
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.87715408
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87038004
89positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.87019377
90regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.87019377
91natural killer cell activation involved in immune response (GO:0002323)2.86404935
92regulation of interleukin-8 secretion (GO:2000482)2.85365561
93antigen processing and presentation via MHC class Ib (GO:0002475)2.84157407
94endoderm formation (GO:0001706)2.83701357
95positive regulation of gamma-delta T cell activation (GO:0046645)2.83306518
96T cell differentiation (GO:0030217)2.81755262
97negative regulation of innate immune response (GO:0045824)2.81647474
98regulation of fibroblast apoptotic process (GO:2000269)2.80160079
99regulation of mitotic spindle checkpoint (GO:1903504)2.78146686
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78146686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.76551173
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.33454913
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.16760858
4RUNX_20019798_ChIP-Seq_JUKART_Human3.92565895
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.29385897
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98845608
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.96814646
8MYB_26560356_Chip-Seq_TH2_Human2.95831619
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70235734
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.69854464
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69670582
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58309296
13GATA3_26560356_Chip-Seq_TH2_Human2.54156924
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53162240
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50971265
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35423660
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.28149320
18GATA3_27048872_Chip-Seq_THYMUS_Human2.08584289
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06158732
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03113443
21IRF1_19129219_ChIP-ChIP_H3396_Human1.97184702
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85508776
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83107032
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75954284
25VDR_23849224_ChIP-Seq_CD4+_Human1.74374157
26MYB_26560356_Chip-Seq_TH1_Human1.74336955
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.69846337
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69252728
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67076346
30ZNF274_21170338_ChIP-Seq_K562_Hela1.64815128
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63085530
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.61813005
33MAF_26560356_Chip-Seq_TH1_Human1.51828954
34UTX_26944678_Chip-Seq_JUKART_Human1.49851053
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.42184901
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38014432
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35858971
38SPI1_23547873_ChIP-Seq_NB4_Human1.35473704
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33830827
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33660805
41BCL6_27268052_Chip-Seq_Bcells_Human1.29771467
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27590744
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.26739905
44TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.25455837
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22427112
46GATA3_26560356_Chip-Seq_TH1_Human1.21945624
47MAF_26560356_Chip-Seq_TH2_Human1.21945490
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.20900143
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20639980
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.20475187
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20359449
52IGF1R_20145208_ChIP-Seq_DFB_Human1.20313738
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19446397
54RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19128482
55AR_20517297_ChIP-Seq_VCAP_Human1.17346328
56STAT1_20625510_ChIP-Seq_HELA_Human1.17248727
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16459700
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15889223
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15636535
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14552653
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13639669
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13501890
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10744068
64VDR_22108803_ChIP-Seq_LS180_Human1.10711120
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08935870
66FOXP3_21729870_ChIP-Seq_TREG_Human1.08815650
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07224116
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06006665
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.05978752
70SCL_19346495_ChIP-Seq_HPC-7_Human1.05139698
71TP53_22573176_ChIP-Seq_HFKS_Human1.03959530
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.03522833
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03053530
74CIITA_25753668_ChIP-Seq_RAJI_Human1.01901362
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01596568
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01443354
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.99555509
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99555509
79P300_27268052_Chip-Seq_Bcells_Human0.97077998
80GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96724494
81HOXB7_26014856_ChIP-Seq_BT474_Human0.95839742
82NANOG_20526341_ChIP-Seq_ESCs_Human0.95612651
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95089343
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94831378
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.93161964
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92980361
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.92229208
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91573877
89GATA1_22025678_ChIP-Seq_K562_Human0.91404522
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87644525
91BCOR_27268052_Chip-Seq_Bcells_Human0.87009366
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86997965
93MYC_18940864_ChIP-ChIP_HL60_Human0.85617558
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85616725
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84245568
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.83966079
97ERA_21632823_ChIP-Seq_H3396_Human0.83798099
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83634912
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83462571
100MYC_19829295_ChIP-Seq_ESCs_Human0.80822815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.77659721
2MP0003724_increased_susceptibility_to4.48107322
3MP0003436_decreased_susceptibility_to4.03184063
4MP0002009_preneoplasia3.55540035
5MP0000465_gastrointestinal_hemorrhage3.23205491
6MP0002166_altered_tumor_susceptibility3.22821288
7MP0003763_abnormal_thymus_physiology3.13732605
8MP0005000_abnormal_immune_tolerance3.05499845
9MP0002933_joint_inflammation3.04610856
10MP0000685_abnormal_immune_system2.97762931
11MP0001835_abnormal_antigen_presentation2.96053880
12MP0006072_abnormal_retinal_apoptosis2.48091575
13MP0002006_tumorigenesis2.47908799
14MP0002723_abnormal_immune_serum2.44361700
15MP0009785_altered_susceptibility_to2.37730434
16MP0001533_abnormal_skeleton_physiology2.37213652
17MP0001800_abnormal_humoral_immune2.37007355
18MP0002148_abnormal_hypersensitivity_rea2.18184333
19MP0001819_abnormal_immune_cell2.17521649
20MP0002420_abnormal_adaptive_immunity2.12386574
21MP0002452_abnormal_antigen_presenting2.11593324
22MP0004947_skin_inflammation2.00111413
23MP0002419_abnormal_innate_immunity1.92434259
24MP0001853_heart_inflammation1.85690665
25MP0002405_respiratory_system_inflammati1.84211775
26MP0005387_immune_system_phenotype1.81797604
27MP0001790_abnormal_immune_system1.81797604
28MP0005025_abnormal_response_to1.79864778
29MP0001501_abnormal_sleep_pattern1.79813561
30MP0005075_abnormal_melanosome_morpholog1.61204559
31MP0002876_abnormal_thyroid_physiology1.59056558
32MP0000716_abnormal_immune_system1.57313974
33MP0005360_urolithiasis1.54952355
34MP0009764_decreased_sensitivity_to1.52867075
35MP0002398_abnormal_bone_marrow1.52403026
36MP0000689_abnormal_spleen_morphology1.49475189
37MP0001845_abnormal_inflammatory_respons1.46839688
38MP0010155_abnormal_intestine_physiology1.42613476
39MP0002722_abnormal_immune_system1.39817536
40MP0009333_abnormal_splenocyte_physiolog1.37250591
41MP0003866_abnormal_defecation1.35383011
42MP0005390_skeleton_phenotype1.35246510
43MP0000703_abnormal_thymus_morphology1.34450636
44MP0002102_abnormal_ear_morphology1.30221693
45MP0005365_abnormal_bile_salt1.26552752
46MP0002429_abnormal_blood_cell1.21103648
47MP0002254_reproductive_system_inflammat1.15774142
48MP0000858_altered_metastatic_potential1.14165609
49MP0003195_calcinosis1.14093900
50MP0002998_abnormal_bone_remodeling1.12075835
51MP0003828_pulmonary_edema1.11438969
52MP0008877_abnormal_DNA_methylation1.11339095
53MP0008875_abnormal_xenobiotic_pharmacok1.09777971
54MP0004147_increased_porphyrin_level1.09216003
55MP0010386_abnormal_urinary_bladder1.06632221
56MP0001919_abnormal_reproductive_system1.02894280
57MP0005253_abnormal_eye_physiology1.01258215
58MP0001542_abnormal_bone_strength1.01055857
59MP0003656_abnormal_erythrocyte_physiolo0.99686688
60MP0001879_abnormal_lymphatic_vessel0.96948947
61MP0001765_abnormal_ion_homeostasis0.96903367
62MP0001243_abnormal_dermal_layer0.95904474
63MP0001851_eye_inflammation0.95597320
64MP0002138_abnormal_hepatobiliary_system0.94766103
65MP0001986_abnormal_taste_sensitivity0.94188061
66MP0001873_stomach_inflammation0.93552064
67MP0003950_abnormal_plasma_membrane0.90393597
68MP0003011_delayed_dark_adaptation0.89658916
69MP0008872_abnormal_physiological_respon0.88645929
70MP0008469_abnormal_protein_level0.87858252
71MP0005464_abnormal_platelet_physiology0.87855275
72MP0003638_abnormal_response/metabolism_0.87624598
73MP0003795_abnormal_bone_structure0.86867345
74MP0008961_abnormal_basal_metabolism0.86853774
75MP0008775_abnormal_heart_ventricle0.84886712
76MP0009763_increased_sensitivity_to0.84463798
77MP0003045_fibrosis0.83263447
78MP0006082_CNS_inflammation0.79875194
79MP0000372_irregular_coat_pigmentation0.79182128
80MP0005377_hearing/vestibular/ear_phenot0.79032624
81MP0003878_abnormal_ear_physiology0.79032624
82MP0005084_abnormal_gallbladder_morpholo0.78155396
83MP0004885_abnormal_endolymph0.76839533
84MP0005389_reproductive_system_phenotype0.76026316
85MP0005551_abnormal_eye_electrophysiolog0.73766508
86MP0010329_abnormal_lipoprotein_level0.73629414
87MP0000013_abnormal_adipose_tissue0.70144022
88MP0003191_abnormal_cellular_cholesterol0.66902287
89MP0003252_abnormal_bile_duct0.66725887
90MP0000249_abnormal_blood_vessel0.66686487
91MP0010368_abnormal_lymphatic_system0.66617308
92MP0001958_emphysema0.66122836
93MP0009840_abnormal_foam_cell0.65723633
94MP0003279_aneurysm0.65540626
95MP0002136_abnormal_kidney_physiology0.65106517
96MP0009780_abnormal_chondrocyte_physiolo0.64481562
97MP0006054_spinal_hemorrhage0.63232652
98MP0005165_increased_susceptibility_to0.62632901
99MP0003879_abnormal_hair_cell0.61881657
100MP0002736_abnormal_nociception_after0.61279665

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)6.52725534
2Severe combined immunodeficiency (HP:0004430)5.85431164
3Elevated erythrocyte sedimentation rate (HP:0003565)4.80416910
4T lymphocytopenia (HP:0005403)4.69365075
5Combined immunodeficiency (HP:0005387)4.57886125
6Stomach cancer (HP:0012126)4.51591497
7Abnormality of eosinophils (HP:0001879)4.42371891
8Abnormality of T cell number (HP:0011839)4.40033198
9Stomatitis (HP:0010280)4.34314930
10Prostate neoplasm (HP:0100787)3.94262605
11Myositis (HP:0100614)3.88790668
12Conical tooth (HP:0000698)3.86109447
13Pustule (HP:0200039)3.77416159
14Thyroiditis (HP:0100646)3.66932833
15Abnormality of T cells (HP:0002843)3.62174172
16Anhidrosis (HP:0000970)3.47538020
17Renal cortical cysts (HP:0000803)3.38909374
18Abnormality of the prostate (HP:0008775)3.28303186
19Eosinophilia (HP:0001880)3.10662555
20Leukocytosis (HP:0001974)3.00001740
21Abnormality of T cell physiology (HP:0011840)2.94127452
22Abnormality of B cell number (HP:0010975)2.87833508
23Retrobulbar optic neuritis (HP:0100654)2.84569229
24Optic neuritis (HP:0100653)2.84569229
25Granulocytopenia (HP:0001913)2.83638433
26Panhypogammaglobulinemia (HP:0003139)2.71631136
27Brittle hair (HP:0002299)2.65855131
28Pulmonary infiltrates (HP:0002113)2.63320098
29B lymphocytopenia (HP:0010976)2.61745613
30Abnormality of the pons (HP:0007361)2.59818302
31Recurrent fungal infections (HP:0002841)2.58982137
32Recurrent bronchitis (HP:0002837)2.58718979
33Pulmonary fibrosis (HP:0002206)2.58212824
34Eczematoid dermatitis (HP:0000976)2.54470583
35Hypoplasia of the pons (HP:0012110)2.52455841
36Orchitis (HP:0100796)2.51391791
37Joint swelling (HP:0001386)2.49831902
38Type II lissencephaly (HP:0007260)2.47526558
39Congenital, generalized hypertrichosis (HP:0004540)2.44992602
40Congenital stationary night blindness (HP:0007642)2.44254582
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38798797
42Abnormal protein N-linked glycosylation (HP:0012347)2.38798797
43Abnormal protein glycosylation (HP:0012346)2.38798797
44Abnormal glycosylation (HP:0012345)2.38798797
45Abnormality of the renal cortex (HP:0011035)2.35445447
46IgA deficiency (HP:0002720)2.28124212
47Facial diplegia (HP:0001349)2.26831804
48Pancreatitis (HP:0001733)2.24563463
49Hypoplasia of the uterus (HP:0000013)2.22889282
50Type I transferrin isoform profile (HP:0003642)2.21357870
51Alveolar cell carcinoma (HP:0006519)2.18390102
52Abolished electroretinogram (ERG) (HP:0000550)2.17675062
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17532178
54Increased IgM level (HP:0003496)2.14250088
55IgM deficiency (HP:0002850)2.12211370
56Chronic diarrhea (HP:0002028)2.11412047
57Growth hormone excess (HP:0000845)2.08950037
58Vasculitis (HP:0002633)2.08272523
59Aplasia/hypoplasia of the uterus (HP:0008684)2.06636275
60Abnormality of male internal genitalia (HP:0000022)2.03298266
61Hypoproteinemia (HP:0003075)2.03290934
62Chronic mucocutaneous candidiasis (HP:0002728)2.01188086
63Recurrent cutaneous fungal infections (HP:0011370)2.01188086
64Neutropenia (HP:0001875)2.00492390
65Progressive microcephaly (HP:0000253)1.98493843
66Persistence of primary teeth (HP:0006335)1.98458547
67Keratoconjunctivitis (HP:0001096)1.98292253
68Hydroxyprolinuria (HP:0003080)1.98082440
69Abnormality of proline metabolism (HP:0010907)1.98082440
70Mediastinal lymphadenopathy (HP:0100721)1.95318421
71Gastrointestinal stroma tumor (HP:0100723)1.95070894
72Clumsiness (HP:0002312)1.94200090
73Dysostosis multiplex (HP:0000943)1.92061046
74Opisthotonus (HP:0002179)1.91178934
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90136005
76Abnormality of dental color (HP:0011073)1.87564933
77Bronchitis (HP:0012387)1.85008019
78Hypergammaglobulinemia (HP:0010702)1.83204890
79Lymphopenia (HP:0001888)1.80313752
80Neoplasm of the tracheobronchial system (HP:0100552)1.79413746
81Esophageal neoplasm (HP:0100751)1.79365120
82Neoplasm of head and neck (HP:0012288)1.79365120
83Hypotrichosis (HP:0001006)1.79253150
84Glomerulopathy (HP:0100820)1.79084833
85Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78699520
86Attenuation of retinal blood vessels (HP:0007843)1.78675822
87Progressive inability to walk (HP:0002505)1.74435777
88Recurrent sinusitis (HP:0011108)1.73675527
89Reduced antithrombin III activity (HP:0001976)1.73592353
90Hemoptysis (HP:0002105)1.73258431
91Gastrointestinal infarctions (HP:0005244)1.71871560
92Inability to walk (HP:0002540)1.71658130
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.71543438
943-Methylglutaconic aciduria (HP:0003535)1.70267107
95Keratitis (HP:0000491)1.69898356
96Abnormal rod and cone electroretinograms (HP:0008323)1.69718546
97Hyperglycinuria (HP:0003108)1.69518310
98Hematochezia (HP:0002573)1.68028591
99Thyroid-stimulating hormone excess (HP:0002925)1.66677987
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.66351673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.57816283
2TXK4.44186891
3GRK64.34318368
4MAP3K143.68968838
5MAP2K23.41437957
6TLK12.89189005
7TESK22.82751780
8JAK12.62013611
9TBK12.60023555
10ZAK2.57606120
11IKBKE2.42470964
12MAPKAPK32.40111110
13IKBKB2.31952521
14MAP4K12.17193646
15FES1.95422341
16ZAP701.81239025
17EPHA31.80912003
18MUSK1.75431144
19KIT1.72116802
20MATK1.57675465
21KDR1.50093707
22NUAK11.49936300
23BMPR21.46677920
24CAMKK21.46622614
25LIMK11.43406317
26MST41.37231637
27MYLK1.36574613
28ADRBK21.29760141
29MAP4K21.20599917
30SYK1.14636834
31GRK11.13744913
32EIF2AK21.07343377
33MAPK71.06683028
34LCK1.01418368
35CSF1R1.00968870
36TESK10.98400567
37PIM10.93978989
38VRK20.92973855
39WNK40.92005689
40ITK0.89980270
41BCKDK0.89457503
42JAK30.84591149
43PINK10.81962568
44BTK0.81547312
45TEC0.80138698
46LYN0.79724542
47DAPK10.75955557
48RPS6KA20.74135373
49CHUK0.72586965
50TRPM70.69380416
51SIK30.64307293
52PRKCQ0.64129506
53MAPKAPK20.62133390
54CDK40.60793357
55TYK20.60206586
56IGF1R0.60100311
57NTRK10.59669548
58PRKD20.59474963
59ERBB30.58800711
60PHKG10.58611884
61PHKG20.58611884
62MAPK40.56068893
63PIK3CG0.53164098
64HCK0.52594134
65MARK30.47893216
66CSK0.47125237
67VRK10.46868689
68OXSR10.46665835
69TRIM280.46625125
70PTK2B0.46254219
71STK390.46184232
72ABL10.46098881
73INSR0.45886166
74RPS6KA60.45799847
75MAPK110.44922964
76FLT30.43292313
77TIE10.39498078
78RPS6KC10.38427416
79RPS6KL10.38427416
80EPHB10.37979256
81CDK190.37424184
82MAP2K10.35441276
83MAP2K70.32961660
84MAPK30.31998735
85IRAK10.31736228
86NEK60.31684596
87PRKCD0.31658920
88FGFR40.29325471
89MAPK130.28490372
90MAP3K40.27438499
91GRK50.26824750
92MAP3K120.25306171
93RPS6KA10.22331807
94MAP2K60.21788923
95RPS6KA50.20341286
96FYN0.20240747
97BLK0.19394075
98FRK0.19002615
99SIK20.18841685
100CSNK1D0.18499817

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.55111034
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.47864816
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06365338
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.97224739
5Graft-versus-host disease_Homo sapiens_hsa053322.93554081
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82877995
7Allograft rejection_Homo sapiens_hsa053302.60642160
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.39321527
9Autoimmune thyroid disease_Homo sapiens_hsa053202.38338137
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23570589
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21718165
12Asthma_Homo sapiens_hsa053102.16370331
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15478773
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12794864
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.02636668
16T cell receptor signaling pathway_Homo sapiens_hsa046601.97475770
17Antigen processing and presentation_Homo sapiens_hsa046121.95625051
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85206503
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80755761
20Type I diabetes mellitus_Homo sapiens_hsa049401.80034949
21Rheumatoid arthritis_Homo sapiens_hsa053231.78868896
22Hematopoietic cell lineage_Homo sapiens_hsa046401.61558967
23TNF signaling pathway_Homo sapiens_hsa046681.60631059
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37609398
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.37011809
26Proteasome_Homo sapiens_hsa030501.33199547
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.30739789
28Regulation of autophagy_Homo sapiens_hsa041401.28795259
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27422678
30Sulfur metabolism_Homo sapiens_hsa009201.25379690
31Linoleic acid metabolism_Homo sapiens_hsa005911.23503748
32Leishmaniasis_Homo sapiens_hsa051401.19642989
33Measles_Homo sapiens_hsa051621.18860148
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.16294308
35Herpes simplex infection_Homo sapiens_hsa051681.14445012
36Tryptophan metabolism_Homo sapiens_hsa003801.08407739
37Malaria_Homo sapiens_hsa051441.08394641
38Phototransduction_Homo sapiens_hsa047441.08269738
39Selenocompound metabolism_Homo sapiens_hsa004501.07021502
40Viral myocarditis_Homo sapiens_hsa054161.04214729
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04203504
42Nitrogen metabolism_Homo sapiens_hsa009101.03826471
43Shigellosis_Homo sapiens_hsa051311.03359631
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03007834
45Arachidonic acid metabolism_Homo sapiens_hsa005901.00691984
46Protein export_Homo sapiens_hsa030601.00239800
47Osteoclast differentiation_Homo sapiens_hsa043800.95161137
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91354237
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85831546
50Apoptosis_Homo sapiens_hsa042100.83331006
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82622246
52RNA polymerase_Homo sapiens_hsa030200.80835429
53Pertussis_Homo sapiens_hsa051330.79382049
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.78050600
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75971760
56Other glycan degradation_Homo sapiens_hsa005110.72165026
57Lysosome_Homo sapiens_hsa041420.71208262
58B cell receptor signaling pathway_Homo sapiens_hsa046620.68789080
59Legionellosis_Homo sapiens_hsa051340.68084286
60Toxoplasmosis_Homo sapiens_hsa051450.65467840
61Caffeine metabolism_Homo sapiens_hsa002320.63231319
62One carbon pool by folate_Homo sapiens_hsa006700.61510675
63Fatty acid elongation_Homo sapiens_hsa000620.59704104
64Ether lipid metabolism_Homo sapiens_hsa005650.56424263
65Staphylococcus aureus infection_Homo sapiens_hsa051500.55339605
66Peroxisome_Homo sapiens_hsa041460.54870142
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54030112
68N-Glycan biosynthesis_Homo sapiens_hsa005100.52933022
69Epstein-Barr virus infection_Homo sapiens_hsa051690.51560617
70Non-homologous end-joining_Homo sapiens_hsa034500.49077535
71RNA degradation_Homo sapiens_hsa030180.49006395
72Taste transduction_Homo sapiens_hsa047420.48767524
73Basal transcription factors_Homo sapiens_hsa030220.46543820
74Collecting duct acid secretion_Homo sapiens_hsa049660.43565586
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42627342
76Chemical carcinogenesis_Homo sapiens_hsa052040.41861822
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41755406
78Sulfur relay system_Homo sapiens_hsa041220.35805139
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.34736631
80Propanoate metabolism_Homo sapiens_hsa006400.34698076
81Tuberculosis_Homo sapiens_hsa051520.34471341
82Fat digestion and absorption_Homo sapiens_hsa049750.30820680
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.30637674
84Vitamin digestion and absorption_Homo sapiens_hsa049770.30636202
85Chemokine signaling pathway_Homo sapiens_hsa040620.30178519
86Salivary secretion_Homo sapiens_hsa049700.28935127
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28860150
88Olfactory transduction_Homo sapiens_hsa047400.25787170
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25315429
90Influenza A_Homo sapiens_hsa051640.24627838
91Base excision repair_Homo sapiens_hsa034100.24449415
92Circadian rhythm_Homo sapiens_hsa047100.24052702
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22941736
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.22439044
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.22370634
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22191579
97Morphine addiction_Homo sapiens_hsa050320.19769641
98HTLV-I infection_Homo sapiens_hsa051660.19757354
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19543773
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18621972

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