ACTBL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.24650785
2hair cycle (GO:0042633)8.24650785
3protein maturation by protein folding (GO:0022417)7.17441526
4extracellular fibril organization (GO:0043206)5.17774786
5response to gravity (GO:0009629)4.91403711
6protein retention in ER lumen (GO:0006621)4.87859125
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.79087009
8pattern specification involved in kidney development (GO:0061004)4.71226264
9actin filament depolymerization (GO:0030042)4.70551785
10regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.61255767
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.60239505
12regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.59181139
13mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.45524632
14Golgi transport vesicle coating (GO:0048200)4.40826468
15COPI coating of Golgi vesicle (GO:0048205)4.40826468
16fibril organization (GO:0097435)4.22175728
17protein neddylation (GO:0045116)4.19048690
18maturation of 5.8S rRNA (GO:0000460)4.07153808
19substrate-dependent cell migration (GO:0006929)4.01392430
20ATP synthesis coupled proton transport (GO:0015986)3.99434517
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99434517
22regulation of isotype switching to IgG isotypes (GO:0048302)3.97143534
23establishment of integrated proviral latency (GO:0075713)3.95176226
24virion assembly (GO:0019068)3.89192923
25positive regulation of actin filament depolymerization (GO:0030836)3.87155687
26positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.86110724
27nuclear envelope reassembly (GO:0031468)3.84925382
28mitotic nuclear envelope reassembly (GO:0007084)3.84925382
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82169373
30type B pancreatic cell proliferation (GO:0044342)3.66900245
31mesodermal cell differentiation (GO:0048333)3.63363731
32muscle cell migration (GO:0014812)3.58921379
33long-chain fatty acid biosynthetic process (GO:0042759)3.58251364
34positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.58080118
35regulation of MHC class II biosynthetic process (GO:0045346)3.57605031
36viral protein processing (GO:0019082)3.55600375
37cellular response to vitamin (GO:0071295)3.53399649
38SMAD protein complex assembly (GO:0007183)3.53379609
39activated T cell proliferation (GO:0050798)3.51741984
40cell adhesion mediated by integrin (GO:0033627)3.50340889
41galactose catabolic process (GO:0019388)3.49668985
42termination of RNA polymerase III transcription (GO:0006386)3.42777618
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.42777618
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38006343
45centriole replication (GO:0007099)3.35977806
46chaperone-mediated protein transport (GO:0072321)3.35594497
47cellular response to exogenous dsRNA (GO:0071360)3.35081493
48ganglion development (GO:0061548)3.32896161
49proteasome assembly (GO:0043248)3.30004558
50hemidesmosome assembly (GO:0031581)3.27734202
51anterograde synaptic vesicle transport (GO:0048490)3.27053348
52sequestering of actin monomers (GO:0042989)3.26009682
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19761127
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16410001
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16410001
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16410001
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14973415
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14973415
59negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.13343198
60regulation of mRNA splicing, via spliceosome (GO:0048024)3.09751999
61detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.09107872
62negative regulation of macroautophagy (GO:0016242)3.06041271
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.05679760
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04133207
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.04133207
66interferon-gamma production (GO:0032609)3.02825199
677-methylguanosine mRNA capping (GO:0006370)3.02413312
68nucleotide-sugar biosynthetic process (GO:0009226)3.02060488
69protein-cofactor linkage (GO:0018065)3.01638541
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00357098
71mesonephros development (GO:0001823)2.99720213
72RNA capping (GO:0036260)2.98516132
737-methylguanosine RNA capping (GO:0009452)2.98516132
74regulation of B cell receptor signaling pathway (GO:0050855)2.96120167
75skin morphogenesis (GO:0043589)2.95563803
76cellular response to zinc ion (GO:0071294)2.94591907
77regulation of metalloenzyme activity (GO:0048552)2.94118061
78defense response to protozoan (GO:0042832)2.94020375
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91976453
80adult feeding behavior (GO:0008343)2.90668569
81desmosome organization (GO:0002934)2.90473748
82nephron tubule formation (GO:0072079)2.90275436
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89516387
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89332287
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89214879
86negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.87260815
87barbed-end actin filament capping (GO:0051016)2.86260065
88regulation of apoptotic process involved in morphogenesis (GO:1902337)2.84930923
89negative regulation of kidney development (GO:0090185)2.83302330
90ribosome assembly (GO:0042255)2.82327909
91endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.81824741
92DNA double-strand break processing (GO:0000729)2.80217319
93mast cell activation (GO:0045576)2.76028574
94fusion of sperm to egg plasma membrane (GO:0007342)2.75504649
95establishment of viral latency (GO:0019043)2.74100603
96facial nerve structural organization (GO:0021612)2.73783379
97regulation of integrin-mediated signaling pathway (GO:2001044)2.73671401
98intermediate filament organization (GO:0045109)2.72651187
99positive regulation of ligase activity (GO:0051351)2.71979892
100cullin deneddylation (GO:0010388)2.71948578
101positive regulation of chemokine biosynthetic process (GO:0045080)2.71746495
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71742214
103regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.71448382
104regulation of cellular amino acid metabolic process (GO:0006521)2.71192338
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70882150
106galactose metabolic process (GO:0006012)2.70873110
107endothelial tube morphogenesis (GO:0061154)2.70305092
108morphogenesis of an endothelium (GO:0003159)2.70305092
109regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.70182723
110regulation of translational termination (GO:0006449)2.68824363
111protein localization to endosome (GO:0036010)2.68407320
112protein K6-linked ubiquitination (GO:0085020)2.66394291
113negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.65807598
114phosphatidylserine acyl-chain remodeling (GO:0036150)2.65015172
115negative regulation of chondrocyte differentiation (GO:0032331)2.64847499
116protein heterotetramerization (GO:0051290)2.63601792
117dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63577895
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63429239
119keratinocyte proliferation (GO:0043616)2.62944377
120UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61802908
121opioid receptor signaling pathway (GO:0038003)2.61469750
122response to testosterone (GO:0033574)2.61357251
123centriole assembly (GO:0098534)2.60771512
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60548958
125negative regulation of ligase activity (GO:0051352)2.60548958
126negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.58760865
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58588382
128platelet dense granule organization (GO:0060155)2.57910967
129polyamine biosynthetic process (GO:0006596)2.56803180
130mesenchymal cell differentiation involved in renal system development (GO:2001012)2.56674392
131mesenchymal cell differentiation involved in kidney development (GO:0072161)2.56674392
132protein hydroxylation (GO:0018126)2.56587204
133membrane raft organization (GO:0031579)2.56275484
134negative regulation of T cell receptor signaling pathway (GO:0050860)2.55682440
135T cell receptor signaling pathway (GO:0050852)2.54499997
136lymphocyte costimulation (GO:0031294)2.53553939
137regulation of spindle organization (GO:0090224)2.53486974
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.53399410
139lipopolysaccharide biosynthetic process (GO:0009103)2.52054462
140hypotonic response (GO:0006971)2.51541196
141positive regulation of epidermal cell differentiation (GO:0045606)2.51513237
142regulation of mitotic spindle organization (GO:0060236)2.51298032
143central nervous system myelination (GO:0022010)2.51193556
144axon ensheathment in central nervous system (GO:0032291)2.51193556
145regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.51112662
146keratinocyte development (GO:0003334)2.50104717
147glomerulus development (GO:0032835)2.49201681
148keratinization (GO:0031424)2.47519296
149negative regulation of metanephros development (GO:0072217)2.47332574
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46962690
151DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.44723764
152positive regulation of cell cycle arrest (GO:0071158)2.44601236
153regulation of axon regeneration (GO:0048679)2.43157225
154regulation of neuron projection regeneration (GO:0070570)2.43157225
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42895229
156positive regulation of chemokine secretion (GO:0090197)2.42321994
157termination of RNA polymerase I transcription (GO:0006363)2.42106689
158T cell costimulation (GO:0031295)2.41624725
159response to protozoan (GO:0001562)2.41514009
160leukocyte aggregation (GO:0070486)2.41450385
161regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41403527
162DNA dealkylation (GO:0035510)2.40503420
163antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.40492023
164transcription from RNA polymerase I promoter (GO:0006360)2.39726182
165ribosomal small subunit assembly (GO:0000028)2.39257116
166DNA deamination (GO:0045006)2.38478249
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37336400
168negative regulation of androgen receptor signaling pathway (GO:0060766)2.37328351
169peptidyl-arginine modification (GO:0018195)2.37147012
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.35570597
171melanosome organization (GO:0032438)2.35550668
172positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33950595
173regulation of T cell receptor signaling pathway (GO:0050856)2.33850767
174pigment granule organization (GO:0048753)2.33069542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.82130436
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.75161691
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.24913059
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.15987303
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.13220563
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46941450
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.41440114
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33335888
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29674025
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.14437378
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.96205745
12* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.85555629
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.69231912
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.67552531
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57235931
16E2F7_22180533_ChIP-Seq_HELA_Human2.48802368
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48408808
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.45564462
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.45564462
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.43427659
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22085144
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15220343
23JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13986617
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09315535
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02458533
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01543046
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00797532
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.96888018
29EZH2_22144423_ChIP-Seq_EOC_Human1.94680662
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94675576
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93541358
32JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93496770
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91114434
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87051780
35ATF3_27146783_Chip-Seq_COLON_Human1.81972238
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77937700
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76216396
38* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.75765014
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73680483
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.70617605
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70580800
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.70375017
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68550329
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.67692172
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67012169
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.64842797
47IRF1_19129219_ChIP-ChIP_H3396_Human1.64125985
48CIITA_25753668_ChIP-Seq_RAJI_Human1.64017030
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57853475
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57258413
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57003440
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55931533
53* CJUN_26792858_Chip-Seq_BT549_Human1.55841485
54GABP_19822575_ChIP-Seq_HepG2_Human1.53214416
55ZNF263_19887448_ChIP-Seq_K562_Human1.50918025
56ELK1_19687146_ChIP-ChIP_HELA_Human1.50549935
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50475810
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46466824
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.45673070
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45005809
61VDR_23849224_ChIP-Seq_CD4+_Human1.43928380
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.43122361
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43092687
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42384683
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42376751
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42027938
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41759624
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40748644
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40446247
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.39999411
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.39126709
72TAF15_26573619_Chip-Seq_HEK293_Human1.39040537
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38923077
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38922358
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38615845
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37769192
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36914425
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33564477
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33341563
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32521684
81AR_21909140_ChIP-Seq_LNCAP_Human1.31590352
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.30849903
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.30725913
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29859347
85* BRD4_25478319_ChIP-Seq_HGPS_Human1.29662345
86CLOCK_20551151_ChIP-Seq_293T_Human1.28972771
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28962383
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24985770
89SOX2_20726797_ChIP-Seq_SW620_Human1.24917594
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24556033
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24248923
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24123274
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23937238
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23279855
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22367661
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21852214
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.21829290
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21788011
99TTF2_22483619_ChIP-Seq_HELA_Human1.21662992
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21531187
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21154915
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20811552
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.20305862
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20087158
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19931971
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.19912387
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19517863
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.18790832
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18786351
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.18760600
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18153431
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.17291555
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.16888114
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.16875676
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16042228
116* TP53_22127205_ChIP-Seq_IMR90_Human1.15436355
117MYC_18940864_ChIP-ChIP_HL60_Human1.14507339
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12210915
119RACK7_27058665_Chip-Seq_MCF-7_Human1.11854641
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.11456168
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11265424
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11223299
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11009610
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10884989
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.10838498
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10009223
127GATA1_22025678_ChIP-Seq_K562_Human1.08564289
128ZFX_18555785_Chip-Seq_ESCs_Mouse1.08122150
129TFEB_21752829_ChIP-Seq_HELA_Human1.07381291
130HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07196674
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.07157639
132MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07109469
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.06087413
134ELF5_23300383_ChIP-Seq_T47D_Human1.05862895
135PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05469148
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05320296
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05192105
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04806888
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04653545
140TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03853089
141CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03762340
142P53_22387025_ChIP-Seq_ESCs_Mouse1.03397350
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03105875
144ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02980130
145SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02036711
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.01830995
147THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01826034
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01548145
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01164211
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01045091
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.99925147
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99480168
153SOX2_18555785_Chip-Seq_ESCs_Mouse0.99308114
154RNF2_27304074_Chip-Seq_NSC_Mouse0.98552837
155CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98381819
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97597388
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97546132
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95949458
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95524376
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94197896
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.94040624
162P300_18555785_Chip-Seq_ESCs_Mouse0.93868069
163XRN2_22483619_ChIP-Seq_HELA_Human0.93520571
164POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93322884
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.93217436
166SPI1_23547873_ChIP-Seq_NB4_Human0.93073376
167MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92870837
168CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92263649
169IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91623718
170TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91298754
171FOXP3_21729870_ChIP-Seq_TREG_Human0.90184166
172PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90053883
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.89721687
174PU1_27457419_Chip-Seq_LIVER_Mouse0.87402358
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84695332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.41157723
2MP0002098_abnormal_vibrissa_morphology3.39538348
3MP0005257_abnormal_intraocular_pressure3.19553595
4MP0008438_abnormal_cutaneous_collagen3.04750494
5MP0003566_abnormal_cell_adhesion3.04124529
6MP0002095_abnormal_skin_pigmentation2.95393376
7MP0004272_abnormal_basement_membrane2.94787304
8MP0000015_abnormal_ear_pigmentation2.90428997
9MP0000579_abnormal_nail_morphology2.85779051
10MP0003191_abnormal_cellular_cholesterol2.83584099
11MP0000383_abnormal_hair_follicle2.78529707
12MP0003705_abnormal_hypodermis_morpholog2.78275574
13MP0002877_abnormal_melanocyte_morpholog2.73889054
14MP0000749_muscle_degeneration2.71410092
15MP0001835_abnormal_antigen_presentation2.58079676
16MP0000569_abnormal_digit_pigmentation2.54006144
17MP0010386_abnormal_urinary_bladder2.50805335
18MP0009379_abnormal_foot_pigmentation2.41799610
19MP0000762_abnormal_tongue_morphology2.30259763
20MP0005671_abnormal_response_to2.29398002
21MP0002132_abnormal_respiratory_system2.28940215
22MP0004381_abnormal_hair_follicle2.19110865
23MP0000750_abnormal_muscle_regeneration2.17834382
24MP0010030_abnormal_orbit_morphology2.16134105
25MP0000647_abnormal_sebaceous_gland2.14132465
26MP0000427_abnormal_hair_cycle2.09906242
27MP0005645_abnormal_hypothalamus_physiol2.02679027
28MP0005083_abnormal_biliary_tract2.00805489
29MP0005310_abnormal_salivary_gland2.00556747
30MP0002060_abnormal_skin_morphology1.96787745
31MP0003806_abnormal_nucleotide_metabolis1.94389998
32MP0002277_abnormal_respiratory_mucosa1.88612613
33MP0005023_abnormal_wound_healing1.87662978
34MP0010368_abnormal_lymphatic_system1.85758534
35MP0002332_abnormal_exercise_endurance1.82224748
36MP0006276_abnormal_autonomic_nervous1.80832419
37MP0001529_abnormal_vocalization1.76829160
38MP0000751_myopathy1.74365005
39MP0000534_abnormal_ureter_morphology1.73577233
40MP0002148_abnormal_hypersensitivity_rea1.72575490
41MP0005451_abnormal_body_composition1.72224609
42MP0003880_abnormal_central_pattern1.72028700
43MP0008789_abnormal_olfactory_epithelium1.71996871
44MP0006292_abnormal_olfactory_placode1.71108299
45MP0003786_premature_aging1.69464938
46MP0003091_abnormal_cell_migration1.67430551
47MP0003787_abnormal_imprinting1.65912097
48MP0000537_abnormal_urethra_morphology1.61681428
49MP0000733_abnormal_muscle_development1.61456919
50MP0009840_abnormal_foam_cell1.60323130
51MP0001299_abnormal_eye_distance/1.59713426
52MP0005174_abnormal_tail_pigmentation1.59692668
53MP0001851_eye_inflammation1.59549629
54MP0010678_abnormal_skin_adnexa1.58952189
55MP0000465_gastrointestinal_hemorrhage1.58170488
56MP0001879_abnormal_lymphatic_vessel1.57704493
57MP0005197_abnormal_uvea_morphology1.54915330
58MP0005165_increased_susceptibility_to1.54138179
59MP0000377_abnormal_hair_follicle1.52615850
60MP0005409_darkened_coat_color1.52552118
61MP0004885_abnormal_endolymph1.50971371
62MP0005000_abnormal_immune_tolerance1.49479160
63MP0002933_joint_inflammation1.49295265
64MP0005058_abnormal_lysosome_morphology1.48633091
65MP0009053_abnormal_anal_canal1.48034928
66MP0005075_abnormal_melanosome_morpholog1.47928598
67MP0003123_paternal_imprinting1.46777987
68MP0005025_abnormal_response_to1.46776165
69MP0009333_abnormal_splenocyte_physiolog1.46681039
70MP0004233_abnormal_muscle_weight1.45906271
71MP0000747_muscle_weakness1.42481138
72MP0002736_abnormal_nociception_after1.41741883
73MP0005394_taste/olfaction_phenotype1.41670168
74MP0005499_abnormal_olfactory_system1.41670168
75MP0001485_abnormal_pinna_reflex1.41317737
76MP0000920_abnormal_myelination1.38589097
77MP0005275_abnormal_skin_tensile1.37857235
78MP0009785_altered_susceptibility_to1.37580705
79MP0002420_abnormal_adaptive_immunity1.37202846
80MP0000759_abnormal_skeletal_muscle1.36199584
81MP0003011_delayed_dark_adaptation1.36077470
82MP0003315_abnormal_perineum_morphology1.36022355
83MP0002163_abnormal_gland_morphology1.35024995
84MP0000858_altered_metastatic_potential1.33106996
85MP0001819_abnormal_immune_cell1.32886582
86MP0003453_abnormal_keratinocyte_physiol1.30113718
87MP0002269_muscular_atrophy1.29688699
88MP0004957_abnormal_blastocyst_morpholog1.29619336
89MP0001905_abnormal_dopamine_level1.27508079
90MP0004742_abnormal_vestibular_system1.26561428
91MP0002723_abnormal_immune_serum1.26412715
92MP0005171_absent_coat_pigmentation1.22622998
93MP0004510_myositis1.22406925
94MP0009697_abnormal_copulation1.21448502
95MP0008007_abnormal_cellular_replicative1.19609663
96MP0002638_abnormal_pupillary_reflex1.18063979
97MP0002089_abnormal_postnatal_growth/wei1.17847258
98MP0005501_abnormal_skin_physiology1.17577263
99MP0002796_impaired_skin_barrier1.15863011
100MP0003300_gastrointestinal_ulcer1.14607124
101MP0001800_abnormal_humoral_immune1.14176026
102MP0002009_preneoplasia1.12447644
103MP0002938_white_spotting1.11010714
104MP0000343_altered_response_to1.09527870
105MP0001968_abnormal_touch/_nociception1.09464326
106MP0003077_abnormal_cell_cycle1.08723530
107MP0001790_abnormal_immune_system1.07932195
108MP0005387_immune_system_phenotype1.07932195
109MP0005670_abnormal_white_adipose1.07272236
110MP0001188_hyperpigmentation1.06962808
111MP0003950_abnormal_plasma_membrane1.06524089
112MP0003942_abnormal_urinary_system1.06106525
113MP0005623_abnormal_meninges_morphology1.05034769
114MP0008260_abnormal_autophagy1.04481683
115MP0002398_abnormal_bone_marrow1.03693042
116MP0000367_abnormal_coat/_hair1.02823180
117MP0001661_extended_life_span1.02585267
118MP0000358_abnormal_cell_content/1.01204335
119MP0002452_abnormal_antigen_presenting0.99865538
120MP0002282_abnormal_trachea_morphology0.98463182
121MP0005330_cardiomyopathy0.96670910
122MP0000716_abnormal_immune_system0.95898888
123MP0010234_abnormal_vibrissa_follicle0.95602920
124MP0005164_abnormal_response_to0.94540522
125MP0008775_abnormal_heart_ventricle0.94510976
126MP0000350_abnormal_cell_proliferation0.94278891
127MP0008058_abnormal_DNA_repair0.93750226
128MP0004947_skin_inflammation0.93214009
129MP0003221_abnormal_cardiomyocyte_apopto0.92803771
130MP0001542_abnormal_bone_strength0.92114352
131MP0001216_abnormal_epidermal_layer0.92017463
132MP0000371_diluted_coat_color0.91812209
133MP0002177_abnormal_outer_ear0.90605297
134MP0004858_abnormal_nervous_system0.90255539
135MP0005408_hypopigmentation0.89800211
136MP0001340_abnormal_eyelid_morphology0.88922488
137MP0010352_gastrointestinal_tract_polyps0.88627307
138MP0001243_abnormal_dermal_layer0.88511015
139MP0002734_abnormal_mechanical_nocicepti0.87299046
140MP0003279_aneurysm0.84480047
141MP0002419_abnormal_innate_immunity0.84182565
142MP0000778_abnormal_nervous_system0.82652924
143MP0000678_abnormal_parathyroid_gland0.82625703
144MP0009780_abnormal_chondrocyte_physiolo0.82465556
145MP0005193_abnormal_anterior_eye0.81887060
146MP0003755_abnormal_palate_morphology0.81328517
147MP0010771_integument_phenotype0.80477718
148MP0000372_irregular_coat_pigmentation0.80298962
149MP0005367_renal/urinary_system_phenotyp0.79770938
150MP0000516_abnormal_urinary_system0.79770938
151MP0002006_tumorigenesis0.78703462
152MP0005166_decreased_susceptibility_to0.78451659
153MP0001186_pigmentation_phenotype0.78197804
154MP0004087_abnormal_muscle_fiber0.77283988
155MP0002896_abnormal_bone_mineralization0.76423677
156MP0001970_abnormal_pain_threshold0.76421694
157MP0000627_abnormal_mammary_gland0.75777605
158MP0005084_abnormal_gallbladder_morpholo0.75172963
159MP0008932_abnormal_embryonic_tissue0.74800833
160MP0003186_abnormal_redox_activity0.74158249
161MP0002295_abnormal_pulmonary_circulatio0.73433725
162MP0001348_abnormal_lacrimal_gland0.73215695
163MP0001849_ear_inflammation0.71745968
164MP0002064_seizures0.71467480
165MP0000703_abnormal_thymus_morphology0.70513589
166MP0001324_abnormal_eye_pigmentation0.70093546
167MP0001915_intracranial_hemorrhage0.69995219
168MP0000685_abnormal_immune_system0.69718294
169MP0009250_abnormal_appendicular_skeleto0.69647205
170MP0002972_abnormal_cardiac_muscle0.69347823
171MP0008057_abnormal_DNA_replication0.69198331
172MP0001764_abnormal_homeostasis0.69179701
173MP0003075_altered_response_to0.69117391
174MP0000689_abnormal_spleen_morphology0.68724940
175MP0000003_abnormal_adipose_tissue0.65946755
176MP0000163_abnormal_cartilage_morphology0.63976625
177MP0009931_abnormal_skin_appearance0.63900754
178MP0002085_abnormal_embryonic_tissue0.63519734

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.72072451
2Woolly hair (HP:0002224)4.02159096
3Short nail (HP:0001799)3.83886459
4Reduced subcutaneous adipose tissue (HP:0003758)3.81354034
5Atrophic scars (HP:0001075)3.76464011
6Vertebral compression fractures (HP:0002953)3.69724784
7Keratoconjunctivitis sicca (HP:0001097)3.49282182
8Abnormality of hair growth rate (HP:0011363)3.48835185
9Slow-growing hair (HP:0002217)3.48835185
10Acute necrotizing encephalopathy (HP:0006965)3.47339710
11Hypotrichosis (HP:0001006)3.41386400
12Osteolytic defects of the hand bones (HP:0009699)3.33442696
13Osteolytic defects of the phalanges of the hand (HP:0009771)3.33442696
14Palpebral edema (HP:0100540)3.30754136
15Parakeratosis (HP:0001036)3.18861357
16Abnormality of cochlea (HP:0000375)3.15723049
17Spondylolisthesis (HP:0003302)3.15534758
18Prominent metopic ridge (HP:0005487)3.12615436
19Keratoconjunctivitis (HP:0001096)3.12197908
20Brittle hair (HP:0002299)3.08568997
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.07728096
22Fibular aplasia (HP:0002990)3.04824162
23Broad face (HP:0000283)3.03988447
24Erythema (HP:0010783)3.02842092
25Microglossia (HP:0000171)3.02718000
26Fragile nails (HP:0001808)3.00004003
27Spinal cord lesions (HP:0100561)2.90455714
28Syringomyelia (HP:0003396)2.90455714
29Oral leukoplakia (HP:0002745)2.89994486
30Papilledema (HP:0001085)2.85594874
31Pili torti (HP:0003777)2.81444159
32Short clavicles (HP:0000894)2.79872266
33Abnormality of the metopic suture (HP:0005556)2.76588977
34Colon cancer (HP:0003003)2.75603303
35Retrobulbar optic neuritis (HP:0100654)2.75126124
36Optic neuritis (HP:0100653)2.75126124
37Hypoplasia of the thymus (HP:0000778)2.73450839
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.71650771
39Optic nerve coloboma (HP:0000588)2.71360315
40Abnormal mitochondria in muscle tissue (HP:0008316)2.71326135
41Increased hepatocellular lipid droplets (HP:0006565)2.69708880
42Congenital ichthyosiform erythroderma (HP:0007431)2.68375416
43Glucose intolerance (HP:0000833)2.68065140
44Mitochondrial inheritance (HP:0001427)2.67724018
45Renal Fanconi syndrome (HP:0001994)2.64446645
46Vacuolated lymphocytes (HP:0001922)2.64290262
47Alopecia of scalp (HP:0002293)2.60361526
48Progressive macrocephaly (HP:0004481)2.59178637
49Morphological abnormality of the inner ear (HP:0011390)2.58583636
50Abnormality of the frontal sinuses (HP:0002687)2.56036566
51Rough bone trabeculation (HP:0100670)2.55917093
52Bifid uvula (HP:0000193)2.54156522
53Aplasia/Hypoplasia of the clavicles (HP:0006710)2.53998949
54Delayed gross motor development (HP:0002194)2.53910335
55Delayed CNS myelination (HP:0002188)2.50240624
56Elevated erythrocyte sedimentation rate (HP:0003565)2.48173014
57Gangrene (HP:0100758)2.47533534
58Distal lower limb muscle weakness (HP:0009053)2.46615251
59Type I transferrin isoform profile (HP:0003642)2.44103229
60Abnormality of the parietal bone (HP:0002696)2.42825691
61Trismus (HP:0000211)2.41745260
62Asplenia (HP:0001746)2.41662347
63Follicular hyperkeratosis (HP:0007502)2.41001971
64Cerebral hypomyelination (HP:0006808)2.40785416
65Trigonocephaly (HP:0000243)2.39290037
66Widely patent fontanelles and sutures (HP:0004492)2.38918383
67Recurrent cutaneous fungal infections (HP:0011370)2.38227045
68Chronic mucocutaneous candidiasis (HP:0002728)2.38227045
69Congenital, generalized hypertrichosis (HP:0004540)2.37802760
70Flattened epiphyses (HP:0003071)2.37120731
71Leukodystrophy (HP:0002415)2.34568940
72Birth length less than 3rd percentile (HP:0003561)2.33207888
73Lissencephaly (HP:0001339)2.32874291
74Thyroid-stimulating hormone excess (HP:0002925)2.32559148
75Selective tooth agenesis (HP:0001592)2.32326085
76Abnormality of the distal phalanges of the toes (HP:0010182)2.32233780
77Heterochromia iridis (HP:0001100)2.31513284
78Abnormal gallbladder physiology (HP:0012438)2.30816165
79Cholecystitis (HP:0001082)2.30816165
80Cardiovascular calcification (HP:0011915)2.30101123
81Abnormality of the prostate (HP:0008775)2.29525371
82Sparse eyelashes (HP:0000653)2.29054142
83Acute encephalopathy (HP:0006846)2.28545679
84Adrenal hypoplasia (HP:0000835)2.27150420
85Nemaline bodies (HP:0003798)2.25375853
86Abnormal protein glycosylation (HP:0012346)2.23434512
87Abnormal glycosylation (HP:0012345)2.23434512
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23434512
89Abnormal protein N-linked glycosylation (HP:0012347)2.23434512
90Focal motor seizures (HP:0011153)2.22710693
91Hypoplasia of the uterus (HP:0000013)2.20442014
92Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20274397
93Abnormal hair laboratory examination (HP:0003328)2.19716579
94Neck muscle weakness (HP:0000467)2.18200716
95Milia (HP:0001056)2.16499570
96Increased CSF lactate (HP:0002490)2.15989577
97Poor head control (HP:0002421)2.14309204
98Neuroendocrine neoplasm (HP:0100634)2.12530558
99Pulmonary fibrosis (HP:0002206)2.11263558
100Natal tooth (HP:0000695)2.11181152
101Bradycardia (HP:0001662)2.11134195
102Vascular calcification (HP:0004934)2.10301579
103Reticulocytopenia (HP:0001896)2.09623633
104Abnormal number of erythroid precursors (HP:0012131)2.08542932
105Retinal dysplasia (HP:0007973)2.08165071
106Thick nail (HP:0001805)2.08024247
107Renal cortical cysts (HP:0000803)2.07132845
108Radial bowing (HP:0002986)2.05586466
109Abnormal hair whorl (HP:0010721)2.05251480
110Acanthosis nigricans (HP:0000956)2.05090381
111T lymphocytopenia (HP:0005403)2.01863629
112Exertional dyspnea (HP:0002875)2.01540482
1133-Methylglutaconic aciduria (HP:0003535)2.00981022
114Duplicated collecting system (HP:0000081)1.99986736
115Amyloidosis (HP:0011034)1.99858409
116Aortic dissection (HP:0002647)1.99387881
117IgM deficiency (HP:0002850)1.99260665
118Albinism (HP:0001022)1.99204089
119Myositis (HP:0100614)1.98658753
120Basal ganglia calcification (HP:0002135)1.98174535
121Abnormality of cells of the erythroid lineage (HP:0012130)1.98163258
122Increased connective tissue (HP:0009025)1.97277062
123Hepatocellular necrosis (HP:0001404)1.97252020
124Multiple lipomas (HP:0001012)1.96911120
125Melanoma (HP:0002861)1.95921501
126Ileus (HP:0002595)1.95053420
127Entropion (HP:0000621)1.94584268
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94556354
129Reduced antithrombin III activity (HP:0001976)1.94431209
130Wormian bones (HP:0002645)1.93319757
131Nail dystrophy (HP:0008404)1.92864369
132Orchitis (HP:0100796)1.92777865
133Protrusio acetabuli (HP:0003179)1.92477248
134IgG deficiency (HP:0004315)1.92142696
135Right ventricular cardiomyopathy (HP:0011663)1.91935550
136Generalized hypopigmentation (HP:0007513)1.91091428
137Hydroureter (HP:0000072)1.91067622
138Tetraparesis (HP:0002273)1.91067363
139Type 2 muscle fiber atrophy (HP:0003554)1.90171434
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89888567
141Abnormality of the umbilical cord (HP:0010881)1.89872922
142Eczematoid dermatitis (HP:0000976)1.88598102
143Interstitial pulmonary disease (HP:0006530)1.88409251
144Renal tubular acidosis (HP:0001947)1.87082687
145Testicular atrophy (HP:0000029)1.85870694
146Agnosia (HP:0010524)1.85848538
147Lipid accumulation in hepatocytes (HP:0006561)1.84999950
148Mitral stenosis (HP:0001718)1.83417076
149Abnormality of glycolipid metabolism (HP:0010969)1.82149598
150Abnormality of liposaccharide metabolism (HP:0010968)1.82149598
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.82149598
152Neurofibrillary tangles (HP:0002185)1.81891305
153Stomach cancer (HP:0012126)1.81857411
154Flat occiput (HP:0005469)1.81836238
155Nasolacrimal duct obstruction (HP:0000579)1.81421946
156Aplasia/hypoplasia of the uterus (HP:0008684)1.80433838
157Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80360989
158Abnormality of renal resorption (HP:0011038)1.80042098
159Keratitis (HP:0000491)1.79914521
160Abnormality of T cell number (HP:0011839)1.79814430
161Conjunctival hamartoma (HP:0100780)1.79468504
162Insulin resistance (HP:0000855)1.76846579
163Abnormality of the renal collecting system (HP:0004742)1.76430430
164Sensory axonal neuropathy (HP:0003390)1.76211505
165Arterial tortuosity (HP:0005116)1.76145805
166Chronic otitis media (HP:0000389)1.75719465
167Abnormality of the aortic arch (HP:0012303)1.75427608
168Chronic obstructive pulmonary disease (HP:0006510)1.75262473
169Obstructive lung disease (HP:0006536)1.75262473
170Panhypogammaglobulinemia (HP:0003139)1.74866329
171Erythroderma (HP:0001019)1.73718816
172Deviation of the thumb (HP:0009603)1.73451334
173Prolonged neonatal jaundice (HP:0006579)1.72695464
174Bowing of the arm (HP:0006488)1.72555346
175Bowed forearm bones (HP:0003956)1.72555346
176Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71960965
177Abnormal trabecular bone morphology (HP:0100671)1.70793028
178Exercise intolerance (HP:0003546)1.70734580
179Difficulty climbing stairs (HP:0003551)1.70689002
180Onycholysis (HP:0001806)1.70288604
181Abnormal delayed hypersensitivity skin test (HP:0002963)1.67955914
182Elbow flexion contracture (HP:0002987)1.65792056
183Muscle fiber inclusion bodies (HP:0100299)1.65321764
184Poor speech (HP:0002465)1.64489617
185Beaking of vertebral bodies (HP:0004568)1.63237413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.54774487
2TXK3.42855352
3VRK23.33282233
4MAP3K123.26527565
5IRAK12.98742389
6NME22.88176062
7LMTK22.75408878
8SIK32.47521008
9DYRK22.43237946
10ARAF2.32324812
11EPHB22.27787023
12IRAK42.25565141
13BLK2.23795132
14CLK12.12702848
15EPHA32.08468871
16IRAK22.06131909
17BMPR21.90713773
18PBK1.87458790
19PAK41.82977367
20DYRK31.81544636
21MST41.76745571
22VRK11.75778990
23IRAK31.74546650
24SRPK11.73565143
25ERBB31.70131251
26PTK21.69287925
27LIMK11.69007670
28MAP3K31.66938742
29MARK11.65830454
30ERBB41.54480153
31MOS1.52402622
32EPHB11.50581520
33MET1.49833494
34MAPK131.48498344
35ABL21.46876449
36DAPK31.44759490
37BUB11.40740232
38PNCK1.34407510
39PHKG11.30546924
40PHKG21.30546924
41STK101.29982048
42ERN11.29014189
43FES1.27065023
44SCYL21.26856089
45NLK1.24777330
46UHMK11.22950491
47MAP4K11.21542293
48LATS21.19934971
49EIF2AK11.19100312
50CCNB11.18807610
51CSNK1G31.17927703
52PRKG21.17417740
53CASK1.16303286
54YES11.09547464
55TESK11.08725952
56MAP2K61.06860884
57MAP3K141.05623776
58CSNK1G11.04832944
59STK161.04544220
60MST1R1.04486853
61SIK11.02819086
62CDK81.00459108
63TESK20.98240097
64TAOK20.91833795
65ZAP700.88454778
66OXSR10.86835164
67CDK190.86599522
68MYLK0.86449468
69MUSK0.84976534
70EIF2AK20.83338826
71TLK10.83099282
72LCK0.82929432
73MKNK10.78777315
74NEK60.76306325
75SMG10.75765685
76SYK0.75579737
77ZAK0.74084795
78CSNK1G20.72543639
79LRRK20.71530024
80TBK10.71116901
81BCR0.70086406
82BCKDK0.70024993
83PRKD30.69366073
84FGFR40.66283902
85STK380.66235482
86CSNK1A1L0.65679222
87MAP3K50.65656437
88DYRK1A0.64923121
89ROCK20.64043096
90ILK0.63890157
91ERBB20.63703468
92FER0.63062411
93CAMK2G0.62599326
94FGFR10.61125351
95MINK10.60862144
96HCK0.60382204
97TRPM70.59409313
98PAK10.59258748
99LYN0.58175665
100MAP3K20.56112801
101HIPK20.55621578
102PRKCQ0.55511262
103BRAF0.55054795
104MAPKAPK30.54609800
105PLK40.54472667
106PRKCI0.54264795
107GRK70.53715941
108CDK180.53363340
109PTK2B0.52350742
110PIM20.50905703
111CAMK2B0.50657608
112CDK70.49442416
113NEK90.48315845
114ROCK10.48229416
115ITK0.47874276
116PAK60.47052021
117MAPKAPK20.45657458
118MAP3K80.45050407
119PAK20.44727293
120PRKCD0.44412546
121NTRK10.43304119
122AURKA0.43014021
123MAP2K70.42859091
124KDR0.42825399
125NTRK30.42798315
126STK38L0.42788703
127MAPK40.41923486
128NEK10.41727443
129CDK150.41626548
130MAP3K110.41185076
131TGFBR20.40573792
132DAPK10.39996993
133RPS6KA50.39692268
134PLK20.39473455
135BRSK10.39281759
136IKBKE0.39207093
137CSNK1A10.38710688
138CSNK2A10.38692398
139CSK0.37979326
140CDK11A0.37866087
141ATR0.36823925
142PASK0.35898472
143EIF2AK30.35842555
144CDC70.34750366
145PTK60.34241503
146FLT30.32520937
147GSK3A0.31507451
148AURKB0.30071248
149TTN0.30045006
150PLK10.28010994
151STK40.27793702
152PRKCE0.27313011
153MAP2K30.26840850
154CDK90.25368810
155AKT20.25331557
156ADRBK10.25050050
157CHEK20.24182975
158MTOR0.22294978

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76601619
2RNA polymerase_Homo sapiens_hsa030203.56768876
3Oxidative phosphorylation_Homo sapiens_hsa001902.87944565
4Sulfur relay system_Homo sapiens_hsa041222.83047515
5Graft-versus-host disease_Homo sapiens_hsa053322.83004822
6Ribosome_Homo sapiens_hsa030102.80042101
7Parkinsons disease_Homo sapiens_hsa050122.66774584
8Spliceosome_Homo sapiens_hsa030402.41277609
9Protein export_Homo sapiens_hsa030602.20325273
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.15978479
11DNA replication_Homo sapiens_hsa030302.14517044
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09103231
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06704826
14Folate biosynthesis_Homo sapiens_hsa007901.97753998
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97480778
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.90317283
17Mismatch repair_Homo sapiens_hsa034301.88921591
18Allograft rejection_Homo sapiens_hsa053301.87804986
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86556260
20Huntingtons disease_Homo sapiens_hsa050161.84409641
21Galactose metabolism_Homo sapiens_hsa000521.84227666
22Alzheimers disease_Homo sapiens_hsa050101.83517990
23Primary immunodeficiency_Homo sapiens_hsa053401.83243024
24Other glycan degradation_Homo sapiens_hsa005111.78646699
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75055738
26Viral myocarditis_Homo sapiens_hsa054161.72221473
27Bladder cancer_Homo sapiens_hsa052191.72194613
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70534787
29Base excision repair_Homo sapiens_hsa034101.70532670
30Pentose phosphate pathway_Homo sapiens_hsa000301.70040726
31Ether lipid metabolism_Homo sapiens_hsa005651.56432973
32Tight junction_Homo sapiens_hsa045301.51897382
33Pyrimidine metabolism_Homo sapiens_hsa002401.50682840
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50471257
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49592721
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48204803
37Nucleotide excision repair_Homo sapiens_hsa034201.41173362
38Shigellosis_Homo sapiens_hsa051311.40273718
39N-Glycan biosynthesis_Homo sapiens_hsa005101.38790354
40Fructose and mannose metabolism_Homo sapiens_hsa000511.38786473
41T cell receptor signaling pathway_Homo sapiens_hsa046601.36710146
42Biosynthesis of amino acids_Homo sapiens_hsa012301.32794736
43Regulation of autophagy_Homo sapiens_hsa041401.30933505
44Vibrio cholerae infection_Homo sapiens_hsa051101.29423170
45Antigen processing and presentation_Homo sapiens_hsa046121.27731188
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25665903
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24901844
48Thyroid cancer_Homo sapiens_hsa052161.21123439
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15641488
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07713589
51Focal adhesion_Homo sapiens_hsa045101.05724115
52Basal transcription factors_Homo sapiens_hsa030221.04211767
53Glutathione metabolism_Homo sapiens_hsa004801.03771386
54Steroid biosynthesis_Homo sapiens_hsa001001.02234300
55Epstein-Barr virus infection_Homo sapiens_hsa051691.00835607
56Proteoglycans in cancer_Homo sapiens_hsa052050.99274109
57Carbon metabolism_Homo sapiens_hsa012000.98849024
58Pyruvate metabolism_Homo sapiens_hsa006200.98790541
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98248114
60ECM-receptor interaction_Homo sapiens_hsa045120.97347124
61RNA degradation_Homo sapiens_hsa030180.96998541
62Salivary secretion_Homo sapiens_hsa049700.96863615
63Arachidonic acid metabolism_Homo sapiens_hsa005900.96355896
64Type I diabetes mellitus_Homo sapiens_hsa049400.94925499
65Small cell lung cancer_Homo sapiens_hsa052220.93915117
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93780535
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90277945
68Legionellosis_Homo sapiens_hsa051340.85078999
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83970670
70Measles_Homo sapiens_hsa051620.81473076
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81164115
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80203750
73Salmonella infection_Homo sapiens_hsa051320.79430004
74Nicotine addiction_Homo sapiens_hsa050330.77943296
75Hippo signaling pathway_Homo sapiens_hsa043900.77327305
76Sulfur metabolism_Homo sapiens_hsa009200.74846416
77Endocytosis_Homo sapiens_hsa041440.74731768
78Phagosome_Homo sapiens_hsa041450.71724204
79Collecting duct acid secretion_Homo sapiens_hsa049660.71073668
80Purine metabolism_Homo sapiens_hsa002300.71049296
81Melanoma_Homo sapiens_hsa052180.69602227
82Autoimmune thyroid disease_Homo sapiens_hsa053200.68297621
83Hematopoietic cell lineage_Homo sapiens_hsa046400.67903027
84Colorectal cancer_Homo sapiens_hsa052100.67379750
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66413604
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66388530
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66340086
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.65409160
89Linoleic acid metabolism_Homo sapiens_hsa005910.64816169
90Axon guidance_Homo sapiens_hsa043600.63794669
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.62403593
92Leishmaniasis_Homo sapiens_hsa051400.61735667
93Homologous recombination_Homo sapiens_hsa034400.61257313
94Cardiac muscle contraction_Homo sapiens_hsa042600.61197878
95RNA transport_Homo sapiens_hsa030130.60143709
96Chronic myeloid leukemia_Homo sapiens_hsa052200.59025817
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58320540
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56550292
99Rheumatoid arthritis_Homo sapiens_hsa053230.56530343
100Asthma_Homo sapiens_hsa053100.55893063
101Hedgehog signaling pathway_Homo sapiens_hsa043400.55815275
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55470207
103Viral carcinogenesis_Homo sapiens_hsa052030.54654361
104Phenylalanine metabolism_Homo sapiens_hsa003600.54641224
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54590415
106Arginine and proline metabolism_Homo sapiens_hsa003300.54575879
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53843860
108HIF-1 signaling pathway_Homo sapiens_hsa040660.53585641
109Pertussis_Homo sapiens_hsa051330.52841049
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.52138927
111Influenza A_Homo sapiens_hsa051640.50597719
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49630351
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.49051842
114Acute myeloid leukemia_Homo sapiens_hsa052210.47908716
115Platelet activation_Homo sapiens_hsa046110.47275296
116Metabolic pathways_Homo sapiens_hsa011000.46632074
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46240127
118Herpes simplex infection_Homo sapiens_hsa051680.46062200
119p53 signaling pathway_Homo sapiens_hsa041150.45945848
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45568472
121Cell cycle_Homo sapiens_hsa041100.45521295
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45120459
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45092921
124Renal cell carcinoma_Homo sapiens_hsa052110.43505161
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.43446659
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.43254802
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.42783624
128Basal cell carcinoma_Homo sapiens_hsa052170.42431301
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41662716
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41396375
131Osteoclast differentiation_Homo sapiens_hsa043800.40295577
132Fanconi anemia pathway_Homo sapiens_hsa034600.40196932
133Fatty acid elongation_Homo sapiens_hsa000620.40098094
134Mineral absorption_Homo sapiens_hsa049780.40067018
135Pathways in cancer_Homo sapiens_hsa052000.40049750
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39654384
137Prostate cancer_Homo sapiens_hsa052150.39583757
138Sphingolipid metabolism_Homo sapiens_hsa006000.39036050
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37815077
140Pancreatic cancer_Homo sapiens_hsa052120.37677493
141Tyrosine metabolism_Homo sapiens_hsa003500.37327231
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.37023890
143Hepatitis C_Homo sapiens_hsa051600.36851112
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36337795
145Serotonergic synapse_Homo sapiens_hsa047260.35939738
146TNF signaling pathway_Homo sapiens_hsa046680.35925785
147B cell receptor signaling pathway_Homo sapiens_hsa046620.35500576
148Taste transduction_Homo sapiens_hsa047420.35477341
149Amoebiasis_Homo sapiens_hsa051460.35407585
150Adherens junction_Homo sapiens_hsa045200.35093894
151Apoptosis_Homo sapiens_hsa042100.34667827
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29976017
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29533422
154HTLV-I infection_Homo sapiens_hsa051660.25341862
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25218110
156Olfactory transduction_Homo sapiens_hsa047400.25213272
157Tuberculosis_Homo sapiens_hsa051520.24121536
158Lysosome_Homo sapiens_hsa041420.23638023
159Systemic lupus erythematosus_Homo sapiens_hsa053220.23567561
160TGF-beta signaling pathway_Homo sapiens_hsa043500.23564754

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