ACTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.66489559
2sequestering of extracellular ligand from receptor (GO:0035581)5.86254601
3wound healing, spreading of epidermal cells (GO:0035313)5.71121462
4collagen fibril organization (GO:0030199)5.46865366
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.46073421
6protein heterotrimerization (GO:0070208)4.91705486
7actin filament depolymerization (GO:0030042)4.89860413
8actin-myosin filament sliding (GO:0033275)4.85876543
9muscle filament sliding (GO:0030049)4.85876543
10wound healing, spreading of cells (GO:0044319)4.72019379
11cell adhesion mediated by integrin (GO:0033627)4.71725838
12skin morphogenesis (GO:0043589)4.71240066
13actin-mediated cell contraction (GO:0070252)4.48366787
14keratan sulfate catabolic process (GO:0042340)4.40799920
15positive regulation of endothelial cell apoptotic process (GO:2000353)4.37410862
16protein localization to cell surface (GO:0034394)4.36435926
17endodermal cell differentiation (GO:0035987)4.35227226
18sarcomere organization (GO:0045214)4.20509689
19extracellular matrix assembly (GO:0085029)4.17412986
20cardiac myofibril assembly (GO:0055003)4.17206294
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.16289813
22negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.14712869
23regulation of tight junction assembly (GO:2000810)4.10034837
24endocardial cushion development (GO:0003197)4.09516935
25bone trabecula formation (GO:0060346)4.07396468
26ventricular cardiac muscle cell development (GO:0055015)4.00926661
27extracellular fibril organization (GO:0043206)3.98253822
28epithelial cell-cell adhesion (GO:0090136)3.89755348
29fibril organization (GO:0097435)3.88030732
30dermatan sulfate biosynthetic process (GO:0030208)3.85800404
31negative regulation of fatty acid transport (GO:2000192)3.84035978
32cranial suture morphogenesis (GO:0060363)3.83068260
33craniofacial suture morphogenesis (GO:0097094)3.83010841
34actomyosin structure organization (GO:0031032)3.79198030
35positive regulation of epithelial to mesenchymal transition (GO:0010718)3.75960742
36stress fiber assembly (GO:0043149)3.69662295
37platelet aggregation (GO:0070527)3.68664044
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68017148
39mesenchymal-epithelial cell signaling (GO:0060638)3.66056046
40protein retention in ER lumen (GO:0006621)3.60033004
41positive regulation of blood vessel endothelial cell migration (GO:0043536)3.58563541
42kidney mesenchyme development (GO:0072074)3.56869399
43cell migration involved in heart development (GO:0060973)3.54898784
44positive regulation of actin filament depolymerization (GO:0030836)3.51322917
45peptidyl-proline hydroxylation (GO:0019511)3.50511712
46plasma membrane repair (GO:0001778)3.49998699
47dermatan sulfate metabolic process (GO:0030205)3.49550503
48chondrocyte development (GO:0002063)3.48882407
49cardiac muscle cell development (GO:0055013)3.47201704
50actin filament-based movement (GO:0030048)3.46464936
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.45567724
52vascular endothelial growth factor signaling pathway (GO:0038084)3.39421361
53cardiac cell development (GO:0055006)3.38596135
54regulation of integrin-mediated signaling pathway (GO:2001044)3.38039904
55neuron projection extension involved in neuron projection guidance (GO:1902284)3.37359376
56axon extension involved in axon guidance (GO:0048846)3.37359376
57protein targeting to plasma membrane (GO:0072661)3.34076317
58positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.29905223
59platelet degranulation (GO:0002576)3.29422861
60apoptotic cell clearance (GO:0043277)3.28204539
61glomerular basement membrane development (GO:0032836)3.27886378
62negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.26738177
63extracellular matrix disassembly (GO:0022617)3.25855594
64atrioventricular valve morphogenesis (GO:0003181)3.23620000
65substrate adhesion-dependent cell spreading (GO:0034446)3.22899302
66Golgi transport vesicle coating (GO:0048200)3.21923635
67COPI coating of Golgi vesicle (GO:0048205)3.21923635
68barbed-end actin filament capping (GO:0051016)3.21575546
69smooth muscle tissue development (GO:0048745)3.21133110
70negative regulation of striated muscle cell apoptotic process (GO:0010664)3.20695789
71negative regulation of chondrocyte differentiation (GO:0032331)3.19413377
72multicellular organismal catabolic process (GO:0044243)3.18154576
73cardiac epithelial to mesenchymal transition (GO:0060317)3.17804528
74multicellular organismal metabolic process (GO:0044236)3.17570345
75negative regulation of protein localization to cell surface (GO:2000009)3.13628901
76negative regulation of nitric-oxide synthase activity (GO:0051001)3.12109789
77basement membrane organization (GO:0071711)3.09592534
78extracellular matrix organization (GO:0030198)3.08237938
79fibroblast migration (GO:0010761)3.07501569
80extracellular structure organization (GO:0043062)3.07497737
81glomerular filtration (GO:0003094)3.07455864
82myofibril assembly (GO:0030239)3.06797063
83collagen metabolic process (GO:0032963)3.06588885
84atrial septum morphogenesis (GO:0060413)3.06004993
85regulation of SMAD protein import into nucleus (GO:0060390)3.05740121
86regulation of smooth muscle cell differentiation (GO:0051150)3.05152757
87protein hydroxylation (GO:0018126)3.03430552
88cellular response to vitamin (GO:0071295)3.01918372
89negative regulation of smooth muscle cell migration (GO:0014912)3.01119086
90heart contraction (GO:0060047)3.00894627
91heart process (GO:0003015)3.00894627
92endocrine hormone secretion (GO:0060986)3.00883885
93extracellular negative regulation of signal transduction (GO:1900116)3.00313176
94extracellular regulation of signal transduction (GO:1900115)3.00313176
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.99914001
96cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.97609504
97adherens junction assembly (GO:0034333)2.97186852
98cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.97081660
99trabecula formation (GO:0060343)2.95298860
100embryonic body morphogenesis (GO:0010172)2.94988612
101regulation of cardiac muscle cell differentiation (GO:2000725)2.94765083
102metanephric mesenchyme development (GO:0072075)2.93942987
103cell-substrate junction assembly (GO:0007044)2.93560293
104renal filtration (GO:0097205)2.93068975
105negative regulation of smooth muscle cell differentiation (GO:0051151)2.92908694
106epithelial to mesenchymal transition (GO:0001837)2.90435504
107positive regulation of macrophage activation (GO:0043032)2.90389692
108cellular response to interferon-alpha (GO:0035457)2.89610257
109cardiac muscle tissue morphogenesis (GO:0055008)2.89291474
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.88810186
111outflow tract septum morphogenesis (GO:0003148)2.88318361
112muscle cell cellular homeostasis (GO:0046716)2.87520033
113membrane raft organization (GO:0031579)2.87226917
114endothelial cell morphogenesis (GO:0001886)2.87162959
115collagen catabolic process (GO:0030574)2.87058454
116regulation of plasminogen activation (GO:0010755)2.86902883
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.86078817
118regulation of skeletal muscle contraction (GO:0014819)2.86060175
119type B pancreatic cell proliferation (GO:0044342)2.85973192
120mesodermal cell differentiation (GO:0048333)2.84812966
121muscle tissue morphogenesis (GO:0060415)2.83463351
122cellular response to vitamin D (GO:0071305)2.83415708
123regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.83375073
124positive regulation of collagen biosynthetic process (GO:0032967)2.82989374
125adhesion of symbiont to host cell (GO:0044650)2.82756161
126virion attachment to host cell (GO:0019062)2.82756161
127multicellular organismal macromolecule metabolic process (GO:0044259)2.82320836
128positive regulation of stem cell differentiation (GO:2000738)2.80648059
129cell aggregation (GO:0098743)2.79788032
130cartilage condensation (GO:0001502)2.79788032
131cell-matrix adhesion (GO:0007160)2.79201060
132hypotonic response (GO:0006971)2.71696274
133cell-substrate adhesion (GO:0031589)2.69663123
134negative regulation of catenin import into nucleus (GO:0035414)2.66079562
135peptide cross-linking (GO:0018149)2.65462505
136muscle cell migration (GO:0014812)2.63959249
137myoblast fusion (GO:0007520)2.63683216
138positive regulation of receptor recycling (GO:0001921)2.61999316
139relaxation of smooth muscle (GO:0044557)2.59138058
140venous blood vessel morphogenesis (GO:0048845)2.55894104
141positive regulation of myoblast differentiation (GO:0045663)2.54255865
142negative regulation of cartilage development (GO:0061037)2.52391382
143pericardium development (GO:0060039)2.51101057
144positive regulation of osteoblast proliferation (GO:0033690)2.50303807
145regulation of muscle hypertrophy (GO:0014743)2.50122454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.14442894
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.14883238
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.33295430
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.23605893
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.86099769
6CLOCK_20551151_ChIP-Seq_293T_Human3.52196085
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.17601749
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.92543877
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.76304750
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74161054
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.70580039
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.56808124
13* CJUN_26792858_Chip-Seq_BT549_Human2.53608798
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43669532
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.37189958
16* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.33557292
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25274322
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22338627
19* BRD4_25478319_ChIP-Seq_HGPS_Human2.20947802
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19076892
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17300360
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12195217
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12195217
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.06644191
25NRF2_20460467_ChIP-Seq_MEFs_Mouse2.05057295
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.05057295
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04977365
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03868497
29ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.96701699
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.95354574
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.94195597
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.90439420
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88085012
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79699593
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77964648
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.77865800
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76838532
38JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75124261
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69866706
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69866706
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69758517
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69346531
43SOX2_20726797_ChIP-Seq_SW620_Human1.67224060
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65423599
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65385950
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63264608
47ATF3_27146783_Chip-Seq_COLON_Human1.61828760
48* TP53_22127205_ChIP-Seq_IMR90_Human1.59583124
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57217211
50SMC1_22415368_ChIP-Seq_MEFs_Mouse1.53300311
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49979278
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46340310
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.46084242
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44946232
55TP53_23651856_ChIP-Seq_MEFs_Mouse1.43569234
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.41646505
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41199600
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.41085883
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.41085883
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40537352
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38852346
62* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38841807
63TP53_16413492_ChIP-PET_HCT116_Human1.36802932
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34127401
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33378298
66* TP53_18474530_ChIP-ChIP_U2OS_Human1.32933494
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.32287442
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31603514
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30772351
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30462241
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29798524
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.29218157
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.26922050
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25999558
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24448386
76RACK7_27058665_Chip-Seq_MCF-7_Human1.24214691
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23511116
78* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.21627652
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21448379
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21202965
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21120837
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19988555
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17799127
84* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16927464
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16569924
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15417872
87* NFI_21473784_ChIP-Seq_ESCs_Mouse1.14244341
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12400490
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11777394
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11205260
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.10190761
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09740302
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.08468085
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08449917
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.06404088
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04872085
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04796362
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04538122
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04275771
100EZH2_27304074_Chip-Seq_ESCs_Mouse1.04112406
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03386923
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03159868
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.02476990
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01693692
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00887179
106EOMES_21245162_ChIP-Seq_HESCs_Human1.00784060
107AHR_22903824_ChIP-Seq_MCF-7_Human1.00549125
108DROSHA_22980978_ChIP-Seq_HELA_Human0.99789345
109SA1_22415368_ChIP-Seq_MEFs_Mouse0.99151735
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99021220
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98710924
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96291760
113GBX2_23144817_ChIP-Seq_PC3_Human0.96159898
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.93945444
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93377421
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.91344663
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91076503
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89741533
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89058551
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88908646
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.85111671
122ELK1_19687146_ChIP-ChIP_HELA_Human0.84239755
123* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83977872
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83721045
125ZNF274_21170338_ChIP-Seq_K562_Hela0.83396542
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82901353
127GATA1_22025678_ChIP-Seq_K562_Human0.82015874
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81080668
129SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80504718
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79324668
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78734878
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.78383507
133* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78146045
134AR_21909140_ChIP-Seq_LNCAP_Human0.77673037
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77349384
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.76936648
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.72336339
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.71191627
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69870269
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69799753
141KLF5_25053715_ChIP-Seq_YYC3_Human0.68824874
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.66368051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.67208348
2MP0003279_aneurysm4.16646701
3MP0005275_abnormal_skin_tensile3.81653749
4MP0005503_abnormal_tendon_morphology3.51037744
5MP0003705_abnormal_hypodermis_morpholog3.44507006
6MP0001958_emphysema3.13945810
7MP0009384_cardiac_valve_regurgitation2.88965505
8MP0003566_abnormal_cell_adhesion2.88647989
9MP0004272_abnormal_basement_membrane2.76711337
10MP0000516_abnormal_urinary_system2.72809362
11MP0005367_renal/urinary_system_phenotyp2.72809362
12MP0005623_abnormal_meninges_morphology2.60482495
13MP0006054_spinal_hemorrhage2.51092675
14MP0010030_abnormal_orbit_morphology2.30422132
15MP0004084_abnormal_cardiac_muscle2.28322687
16MP0000749_muscle_degeneration2.20235909
17MP0005023_abnormal_wound_healing2.08418545
18MP0000013_abnormal_adipose_tissue2.03474627
19MP0003091_abnormal_cell_migration1.98808269
20MP0005257_abnormal_intraocular_pressure1.90403853
21MP0002295_abnormal_pulmonary_circulatio1.89876076
22MP0010352_gastrointestinal_tract_polyps1.88979033
23MP0001542_abnormal_bone_strength1.82972216
24MP0003941_abnormal_skin_development1.75172614
25MP0003385_abnormal_body_wall1.75109961
26MP0010386_abnormal_urinary_bladder1.73421969
27MP0000767_abnormal_smooth_muscle1.72250805
28MP0005508_abnormal_skeleton_morphology1.71918063
29MP0010368_abnormal_lymphatic_system1.71873348
30MP0000750_abnormal_muscle_regeneration1.68453510
31MP0005330_cardiomyopathy1.68191923
32MP0003950_abnormal_plasma_membrane1.54927842
33MP0009250_abnormal_appendicular_skeleto1.50418081
34MP0000534_abnormal_ureter_morphology1.47924242
35MP0009780_abnormal_chondrocyte_physiolo1.47093566
36MP0002060_abnormal_skin_morphology1.43826571
37MP0004036_abnormal_muscle_relaxation1.43734185
38MP0009053_abnormal_anal_canal1.43414034
39MP0008775_abnormal_heart_ventricle1.35708902
40MP0004087_abnormal_muscle_fiber1.34718577
41MP0002972_abnormal_cardiac_muscle1.33516983
42* MP0005620_abnormal_muscle_contractility1.33456729
43MP0001243_abnormal_dermal_layer1.31797047
44MP0001879_abnormal_lymphatic_vessel1.29926483
45MP0004145_abnormal_muscle_electrophysio1.28365667
46MP0000733_abnormal_muscle_development1.28003123
47MP0001299_abnormal_eye_distance/1.27462853
48MP0000751_myopathy1.26276853
49MP0002837_dystrophic_cardiac_calcinosis1.25655116
50MP0003828_pulmonary_edema1.24170596
51MP0006138_congestive_heart_failure1.23527331
52MP0003942_abnormal_urinary_system1.23097707
53MP0002877_abnormal_melanocyte_morpholog1.22220072
54MP0000462_abnormal_digestive_system1.19345798
55* MP0005595_abnormal_vascular_smooth1.15613894
56MP0002282_abnormal_trachea_morphology1.11721777
57MP0010630_abnormal_cardiac_muscle1.11069032
58MP0005390_skeleton_phenotype1.04855406
59MP0004858_abnormal_nervous_system1.03860286
60MP0000538_abnormal_urinary_bladder1.02549665
61* MP0002128_abnormal_blood_circulation1.01820231
62MP0000163_abnormal_cartilage_morphology0.99973705
63MP0005164_abnormal_response_to0.99931880
64MP0000759_abnormal_skeletal_muscle0.98451150
65MP0003115_abnormal_respiratory_system0.98133582
66MP0004883_abnormal_blood_vessel0.97282429
67MP0001544_abnormal_cardiovascular_syste0.97006442
68MP0005385_cardiovascular_system_phenoty0.97006442
69MP0002108_abnormal_muscle_morphology0.96741072
70MP0002896_abnormal_bone_mineralization0.96638209
71MP0001348_abnormal_lacrimal_gland0.95615427
72* MP0001614_abnormal_blood_vessel0.94365430
73MP0000003_abnormal_adipose_tissue0.92966839
74MP0003755_abnormal_palate_morphology0.92383666
75MP0005171_absent_coat_pigmentation0.90296699
76MP0002269_muscular_atrophy0.88833572
77* MP0000230_abnormal_systemic_arterial0.88558837
78MP0005670_abnormal_white_adipose0.87460382
79MP0002254_reproductive_system_inflammat0.86117801
80MP0002133_abnormal_respiratory_system0.85838541
81MP0005388_respiratory_system_phenotype0.85838541
82MP0002933_joint_inflammation0.85051873
83MP0002925_abnormal_cardiovascular_devel0.82803498
84MP0000747_muscle_weakness0.82541239
85MP0002115_abnormal_skeleton_extremities0.81552005
86MP0003283_abnormal_digestive_organ0.79858083
87MP0008004_abnormal_stomach_pH0.79607998
88MP0000428_abnormal_craniofacial_morphol0.79033129
89MP0003045_fibrosis0.78661421
90MP0004233_abnormal_muscle_weight0.78063764
91MP0002113_abnormal_skeleton_development0.76642695
92MP0001533_abnormal_skeleton_physiology0.76391911
93MP0009379_abnormal_foot_pigmentation0.75251476
94MP0001175_abnormal_lung_morphology0.74849255
95MP0004215_abnormal_myocardial_fiber0.73218572
96MP0000266_abnormal_heart_morphology0.72686505
97MP0002932_abnormal_joint_morphology0.71687893
98MP0005084_abnormal_gallbladder_morpholo0.71663033
99MP0005165_increased_susceptibility_to0.70876537
100MP0004134_abnormal_chest_morphology0.70274839
101MP0005375_adipose_tissue_phenotype0.68784703
102MP0000858_altered_metastatic_potential0.68464354
103MP0005369_muscle_phenotype0.67621677
104MP0002106_abnormal_muscle_physiology0.65972771
105MP0002127_abnormal_cardiovascular_syste0.65945830
106MP0000762_abnormal_tongue_morphology0.65803981
107MP0001664_abnormal_digestion0.65582298
108MP0003935_abnormal_craniofacial_develop0.64286664
109MP0002089_abnormal_postnatal_growth/wei0.63378641
110MP0000343_altered_response_to0.62788672
111MP0005409_darkened_coat_color0.62491683
112MP0008007_abnormal_cellular_replicative0.62266991
113MP0002114_abnormal_axial_skeleton0.61973258
114MP0002168_other_aberrant_phenotype0.61265723
115MP0003303_peritoneal_inflammation0.60940785
116MP0000537_abnormal_urethra_morphology0.60280268
117MP0005193_abnormal_anterior_eye0.60213238
118MP0001756_abnormal_urination0.60128797
119MP0000049_abnormal_middle_ear0.59970477
120MP0001270_distended_abdomen0.58405385
121MP0000432_abnormal_head_morphology0.58165332
122MP0003795_abnormal_bone_structure0.56262940

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.17344691
2Protrusio acetabuli (HP:0003179)7.98192977
3* Aortic aneurysm (HP:0004942)5.40029799
4* Aortic dissection (HP:0002647)5.32970117
5Soft skin (HP:0000977)4.26621561
6Peritonitis (HP:0002586)4.24439024
7Abnormality of dentin (HP:0010299)4.01651400
8Type 1 muscle fiber predominance (HP:0003803)3.95896966
9Ankle contracture (HP:0006466)3.91917088
10Atrophic scars (HP:0001075)3.82480393
11Vertebral compression fractures (HP:0002953)3.78537366
12Spinal rigidity (HP:0003306)3.75351172
13Biconcave vertebral bodies (HP:0004586)3.69357464
14Wormian bones (HP:0002645)3.67046508
15* Dilatation of the ascending aorta (HP:0005111)3.64178989
16Shallow orbits (HP:0000586)3.61552931
17Bladder diverticulum (HP:0000015)3.43121172
18Fragile skin (HP:0001030)3.39326658
19Spondylolisthesis (HP:0003302)3.31647563
20Scapular winging (HP:0003691)3.31533040
21Increased density of long bones (HP:0006392)3.29517880
22Increased connective tissue (HP:0009025)3.24138221
23Blue sclerae (HP:0000592)3.18309534
24Vascular tortuosity (HP:0004948)3.07095024
25Right ventricular cardiomyopathy (HP:0011663)3.06017653
26Pulmonary artery stenosis (HP:0004415)2.99285661
27Short nail (HP:0001799)2.92032163
28Wrist flexion contracture (HP:0001239)2.87585052
29Round ear (HP:0100830)2.83609900
30Abnormality of the calcaneus (HP:0008364)2.83186157
31Mitral valve prolapse (HP:0001634)2.83016937
32Neonatal short-limb short stature (HP:0008921)2.80522368
33Cervical subluxation (HP:0003308)2.75113127
34Mesomelia (HP:0003027)2.71567456
35Abnormal delivery (HP:0001787)2.69676540
36Mildly elevated creatine phosphokinase (HP:0008180)2.69198798
37Joint laxity (HP:0001388)2.67265826
38Genu recurvatum (HP:0002816)2.65301222
39Mitral regurgitation (HP:0001653)2.63995564
40Elbow flexion contracture (HP:0002987)2.61398277
41Osteolytic defects of the hand bones (HP:0009699)2.53847993
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.53847993
43Bowel diverticulosis (HP:0005222)2.50651362
44Increased variability in muscle fiber diameter (HP:0003557)2.50139407
45Aortic regurgitation (HP:0001659)2.49528287
46* Aneurysm (HP:0002617)2.49016618
47Ectopia lentis (HP:0001083)2.48270053
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48061450
49Lipoatrophy (HP:0100578)2.46593356
50Broad metatarsal (HP:0001783)2.44861105
51Hypoplasia of the iris (HP:0007676)2.44429792
52Calcaneovalgus deformity (HP:0001848)2.41820169
53Distal lower limb muscle weakness (HP:0009053)2.40365375
54Nemaline bodies (HP:0003798)2.39420274
55Infantile muscular hypotonia (HP:0008947)2.38496539
56Overgrowth (HP:0001548)2.37938193
57* Cerebral aneurysm (HP:0004944)2.36641253
58Camptodactyly of toe (HP:0001836)2.35707380
59Joint stiffness (HP:0001387)2.33622394
60Aortic valve stenosis (HP:0001650)2.32418705
61Abnormality of skeletal muscle fiber size (HP:0012084)2.30986880
62Hyperextensible skin (HP:0000974)2.30399809
63Limited hip movement (HP:0008800)2.29782773
64Absent frontal sinuses (HP:0002688)2.29571686
65Abnormality of the acetabulum (HP:0003170)2.26611144
66Hip contracture (HP:0003273)2.25289186
67Wide anterior fontanel (HP:0000260)2.25025537
68Gowers sign (HP:0003391)2.24756036
69* Gastrointestinal dysmotility (HP:0002579)2.24322592
70Distal arthrogryposis (HP:0005684)2.24167876
71Ulnar deviation of the wrist (HP:0003049)2.20959237
72Hyporeflexia of lower limbs (HP:0002600)2.20951422
73Deformed tarsal bones (HP:0008119)2.20626000
74Muscle fiber inclusion bodies (HP:0100299)2.19396181
75Broad face (HP:0000283)2.18457169
76Popliteal pterygium (HP:0009756)2.18012460
77Abnormality of the calf musculature (HP:0001430)2.17754554
78Difficulty climbing stairs (HP:0003551)2.17257157
79Osteoarthritis (HP:0002758)2.17178193
80Knee flexion contracture (HP:0006380)2.16333111
81Facial diplegia (HP:0001349)2.13914142
82Neoplasm of the heart (HP:0100544)2.13793040
83Thin ribs (HP:0000883)2.12535556
84Arterial tortuosity (HP:0005116)2.08686797
85Venous insufficiency (HP:0005293)2.08619009
86Muscle fiber splitting (HP:0003555)2.08566897
87EMG: myopathic abnormalities (HP:0003458)2.04183234
88Tarsal synostosis (HP:0008368)2.02622143
89Follicular hyperkeratosis (HP:0007502)2.01096889
90Radial bowing (HP:0002986)2.00751064
91Distal lower limb amyotrophy (HP:0008944)1.98571527
92Bradycardia (HP:0001662)1.98481507
93Broad ribs (HP:0000885)1.95541456
94Tibial bowing (HP:0002982)1.94949311
95Striae distensae (HP:0001065)1.94699313
96Mild short stature (HP:0003502)1.94463575
97Abnormality of the shoulder girdle musculature (HP:0001435)1.94238301
98Nonimmune hydrops fetalis (HP:0001790)1.93934681
99Ventricular tachycardia (HP:0004756)1.92352252
100Breech presentation (HP:0001623)1.92241766
101Neck muscle weakness (HP:0000467)1.92181527
102Asymmetric septal hypertrophy (HP:0001670)1.91399569
103Type 2 muscle fiber atrophy (HP:0003554)1.91000176
104Malnutrition (HP:0004395)1.90382416
105Venous abnormality (HP:0002624)1.90065847
106Short hallux (HP:0010109)1.87462641
107Ulnar bowing (HP:0003031)1.87153209
108Achilles tendon contracture (HP:0001771)1.87120100
109Syringomyelia (HP:0003396)1.86821472
110Spinal cord lesions (HP:0100561)1.86821472
111Sudden death (HP:0001699)1.86358207
112Keratoconus (HP:0000563)1.86326915
113Increased corneal curvature (HP:0100692)1.86326915
114Persistence of primary teeth (HP:0006335)1.85638835
115Coxa vara (HP:0002812)1.85304263
116Mitral stenosis (HP:0001718)1.84473597
117Distal upper limb amyotrophy (HP:0007149)1.83483882
118Upper limb amyotrophy (HP:0009129)1.83483882
119Bicuspid aortic valve (HP:0001647)1.83115204
120Thin bony cortex (HP:0002753)1.81999383
121Hypoplastic ischia (HP:0003175)1.81176483
122Limb-girdle muscle atrophy (HP:0003797)1.80909245
123Atrial fibrillation (HP:0005110)1.80605422
124Hypoventilation (HP:0002791)1.80543559
125Slender build (HP:0001533)1.80462239
126Trismus (HP:0000211)1.80375395
127Increased mean platelet volume (HP:0011877)1.80374564
128Abnormality of the ischium (HP:0003174)1.79817380
129Flexion contracture of toe (HP:0005830)1.79710355
130Joint contractures involving the joints of the feet (HP:0100492)1.79710355
131Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79244019
132Coronal craniosynostosis (HP:0004440)1.78588177
133Broad long bones (HP:0005622)1.77145280
134Redundant skin (HP:0001582)1.76739637
135Inguinal hernia (HP:0000023)1.75873552
136Delayed gross motor development (HP:0002194)1.74633856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.20993644
2TTN5.14335497
3MUSK5.06544309
4TESK14.47722602
5LIMK14.01534157
6PIK3CG3.01573353
7PAK22.86172833
8PIK3CA2.81730136
9DMPK2.78088451
10TRIB32.52930571
11DDR22.49817998
12LATS22.36261456
13TESK22.14161666
14PDGFRA2.02776054
15OBSCN1.93237611
16PTK2B1.88118086
17PKN21.86272846
18TRPM71.85008644
19DAPK31.71344673
20PAK31.71194927
21FER1.70647868
22STK38L1.67665965
23CDC42BPA1.67079945
24EPHB21.63713203
25PIM21.63659400
26ZAK1.63082271
27MAPKAPK31.47544881
28ILK1.46705556
29LATS11.46300548
30PRKD21.42375292
31ROCK11.35724997
32PTK21.27367858
33TIE11.27096042
34NUAK11.19621481
35MAP3K61.14272572
36PAK11.12243015
37AKT31.10860621
38ERN11.09483710
39ERBB31.06583343
40RPS6KA41.05500533
41MAP3K121.01426551
42KIT0.99840172
43STK380.99092093
44MAPK70.94926301
45EIF2AK10.93258957
46MOS0.92485256
47NEK90.87896041
48NME20.82577071
49LRRK20.78080205
50EPHB10.77588065
51MAP2K10.75597293
52NTRK10.75113935
53MET0.74100597
54MAP3K70.72569599
55STK30.72334641
56EPHA20.71853527
57GSK3A0.65570774
58EPHA30.65118913
59KDR0.65101499
60MELK0.64547704
61FRK0.63911661
62CCNB10.63274480
63RIPK10.62618554
64MARK20.61805016
65PAK40.61580624
66FGFR10.60235828
67PRKD30.60235778
68BMX0.59061675
69CDK140.58051344
70WNK10.54893985
71MAP3K110.54746197
72ROCK20.54366973
73PRKG20.54095352
74MAP3K30.53593370
75BUB10.52587423
76FLT30.52331271
77FGFR40.51553073
78ABL20.50756549
79MAPK120.49213048
80MAPK40.48615688
81PRKD10.46839685
82GRK70.45934136
83CDK150.45852116
84MAP2K30.45177830
85MAP3K80.43802888
86INSR0.43170710
87CDK180.43008640
88STK240.41837887
89PDGFRB0.41191113
90MAPKAPK20.40708223
91MTOR0.40160374
92NLK0.40045276
93PTK60.38989611
94CAMK2B0.38979054
95LMTK20.38947907
96SCYL20.38388015
97RPS6KC10.38149738
98RPS6KL10.38149738
99CDK80.37778624
100TGFBR20.37533066
101CDK11A0.37525242
102RAF10.36768934
103STK390.36737077
104STK100.36307696
105PLK20.35855844
106PRKCE0.35737951
107CAMK2G0.35016818
108JAK10.34835679
109TAOK10.34057847
110BRSK20.32693247
111FGFR20.32044122
112TAOK20.31501740
113NEK10.30796455
114WNK40.30577447
115RPS6KB20.30382439
116CAMK2D0.30230616
117CAMK10.29777682
118RPS6KA60.28994694
119PRKCH0.27706554
120EEF2K0.27223252
121RPS6KA20.27201792
122MKNK10.26725011
123PRKAA20.26438181
124MAP3K50.25840881
125MAPKAPK50.24917808
126FYN0.24882061
127HIPK20.24780562
128FGFR30.23370153
129ADRBK10.22796962
130SRC0.22781073
131TGFBR10.22723201
132SIK10.22211777
133EGFR0.22194163
134AURKB0.21925699
135RET0.21625375
136PDK30.19584706
137PDK40.19584706
138DYRK1B0.18284959

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.16175901
2Dilated cardiomyopathy_Homo sapiens_hsa054143.78542378
3ECM-receptor interaction_Homo sapiens_hsa045123.51879357
4Focal adhesion_Homo sapiens_hsa045103.50864919
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.84641301
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.83049339
7Bladder cancer_Homo sapiens_hsa052192.81023481
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.62568019
9Proteoglycans in cancer_Homo sapiens_hsa052052.47139044
10TGF-beta signaling pathway_Homo sapiens_hsa043502.39387017
11Adherens junction_Homo sapiens_hsa045202.21184686
12Cardiac muscle contraction_Homo sapiens_hsa042602.07632847
13Hippo signaling pathway_Homo sapiens_hsa043902.07592893
14Amoebiasis_Homo sapiens_hsa051461.97784675
15Malaria_Homo sapiens_hsa051441.94094194
16Shigellosis_Homo sapiens_hsa051311.94016222
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.93521442
18Tight junction_Homo sapiens_hsa045301.92934163
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.91886306
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88813259
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.80449880
22* Vascular smooth muscle contraction_Homo sapiens_hsa042701.69534092
23MicroRNAs in cancer_Homo sapiens_hsa052061.64378633
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.58417906
25p53 signaling pathway_Homo sapiens_hsa041151.52538418
26Viral myocarditis_Homo sapiens_hsa054161.49970568
27Protein digestion and absorption_Homo sapiens_hsa049741.45919459
28Small cell lung cancer_Homo sapiens_hsa052221.44236152
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44143296
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36053117
31Complement and coagulation cascades_Homo sapiens_hsa046101.31797918
32Platelet activation_Homo sapiens_hsa046111.30990278
33HIF-1 signaling pathway_Homo sapiens_hsa040661.29550491
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25136180
35Melanoma_Homo sapiens_hsa052181.15893955
36Protein export_Homo sapiens_hsa030601.13970938
37Chronic myeloid leukemia_Homo sapiens_hsa052201.13447358
38Renin secretion_Homo sapiens_hsa049241.09817226
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.02340430
40Rap1 signaling pathway_Homo sapiens_hsa040150.97927975
41Salmonella infection_Homo sapiens_hsa051320.96958776
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93042830
43Basal cell carcinoma_Homo sapiens_hsa052170.88739833
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86648525
45HTLV-I infection_Homo sapiens_hsa051660.83812936
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82425026
47PPAR signaling pathway_Homo sapiens_hsa033200.81437190
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79657803
49Pathways in cancer_Homo sapiens_hsa052000.77707113
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77575070
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.77382629
52Oxytocin signaling pathway_Homo sapiens_hsa049210.76693719
53Phagosome_Homo sapiens_hsa041450.76176368
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75494268
55Glioma_Homo sapiens_hsa052140.73326110
56Hedgehog signaling pathway_Homo sapiens_hsa043400.72399205
57Gap junction_Homo sapiens_hsa045400.72186129
58Pancreatic cancer_Homo sapiens_hsa052120.71115577
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69143953
60Circadian rhythm_Homo sapiens_hsa047100.68942846
61Wnt signaling pathway_Homo sapiens_hsa043100.68742455
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68291886
63Notch signaling pathway_Homo sapiens_hsa043300.66150808
64Endocytosis_Homo sapiens_hsa041440.63974473
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62968998
66TNF signaling pathway_Homo sapiens_hsa046680.62688346
67Calcium signaling pathway_Homo sapiens_hsa040200.62375926
68Cell cycle_Homo sapiens_hsa041100.61605730
69Salivary secretion_Homo sapiens_hsa049700.60198342
70Prostate cancer_Homo sapiens_hsa052150.60129459
71Proteasome_Homo sapiens_hsa030500.59433566
72Prion diseases_Homo sapiens_hsa050200.58955121
73Apoptosis_Homo sapiens_hsa042100.58480903
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58146227
75Gastric acid secretion_Homo sapiens_hsa049710.57550086
76Glutathione metabolism_Homo sapiens_hsa004800.57125862
77Vibrio cholerae infection_Homo sapiens_hsa051100.57043535
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56034163
79Axon guidance_Homo sapiens_hsa043600.56026468
80cAMP signaling pathway_Homo sapiens_hsa040240.55344115
81Renal cell carcinoma_Homo sapiens_hsa052110.54914536
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53973580
83Dorso-ventral axis formation_Homo sapiens_hsa043200.51906445
84Galactose metabolism_Homo sapiens_hsa000520.51750597
85Sulfur metabolism_Homo sapiens_hsa009200.51714639
86Toxoplasmosis_Homo sapiens_hsa051450.51513696
87Renin-angiotensin system_Homo sapiens_hsa046140.50046090
88Histidine metabolism_Homo sapiens_hsa003400.47270156
89N-Glycan biosynthesis_Homo sapiens_hsa005100.46954080
90Estrogen signaling pathway_Homo sapiens_hsa049150.45505534
91Hepatitis B_Homo sapiens_hsa051610.45307775
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44819819
93Thyroid cancer_Homo sapiens_hsa052160.44795357
94VEGF signaling pathway_Homo sapiens_hsa043700.44236973
95Carbon metabolism_Homo sapiens_hsa012000.44060911
96Viral carcinogenesis_Homo sapiens_hsa052030.43934595
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43696845
98Insulin resistance_Homo sapiens_hsa049310.43485173
99Melanogenesis_Homo sapiens_hsa049160.43403576
100Cocaine addiction_Homo sapiens_hsa050300.40982427
101Leishmaniasis_Homo sapiens_hsa051400.40973166
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40723496
103Other glycan degradation_Homo sapiens_hsa005110.38111061
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37550886
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37332034
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.36838101
107Lysine degradation_Homo sapiens_hsa003100.36779208
108Pertussis_Homo sapiens_hsa051330.36358709
109AMPK signaling pathway_Homo sapiens_hsa041520.35995330
110Ras signaling pathway_Homo sapiens_hsa040140.35760071
111Pancreatic secretion_Homo sapiens_hsa049720.35493232
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34744743
113Biosynthesis of amino acids_Homo sapiens_hsa012300.34254726
114One carbon pool by folate_Homo sapiens_hsa006700.33297845
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33245708
116Insulin signaling pathway_Homo sapiens_hsa049100.33157961
117Fatty acid degradation_Homo sapiens_hsa000710.33034598
118Inositol phosphate metabolism_Homo sapiens_hsa005620.32913247
119Colorectal cancer_Homo sapiens_hsa052100.32702965
120GnRH signaling pathway_Homo sapiens_hsa049120.31764518
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31042001
122ErbB signaling pathway_Homo sapiens_hsa040120.30411104
123Mineral absorption_Homo sapiens_hsa049780.29989591
124Insulin secretion_Homo sapiens_hsa049110.29848511
125FoxO signaling pathway_Homo sapiens_hsa040680.29609074
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.29313894
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28943678
128Ovarian steroidogenesis_Homo sapiens_hsa049130.28333501
129Cholinergic synapse_Homo sapiens_hsa047250.27830847
130MAPK signaling pathway_Homo sapiens_hsa040100.27343149
131Arachidonic acid metabolism_Homo sapiens_hsa005900.26351144
132Thyroid hormone synthesis_Homo sapiens_hsa049180.26122964
133Endometrial cancer_Homo sapiens_hsa052130.25484438
134Glucagon signaling pathway_Homo sapiens_hsa049220.25084537
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24443996

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