ACSL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.03883544
2very-low-density lipoprotein particle assembly (GO:0034379)5.85378983
3plasma lipoprotein particle assembly (GO:0034377)5.41612463
4protein-lipid complex assembly (GO:0065005)5.11294141
5regulation of apoptotic cell clearance (GO:2000425)5.02447932
6low-density lipoprotein particle remodeling (GO:0034374)4.98221857
7regulation of fibrinolysis (GO:0051917)4.96530120
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29609099
9plasma lipoprotein particle clearance (GO:0034381)4.27817072
10cell adhesion mediated by integrin (GO:0033627)4.23065623
11negative regulation of protein activation cascade (GO:2000258)4.21317015
12regulation of cholesterol homeostasis (GO:2000188)4.01121929
13plasma lipoprotein particle organization (GO:0071827)3.96544432
14protein-lipid complex subunit organization (GO:0071825)3.88799167
15pinocytosis (GO:0006907)3.85888770
16macromolecular complex remodeling (GO:0034367)3.84371064
17plasma lipoprotein particle remodeling (GO:0034369)3.84371064
18protein-lipid complex remodeling (GO:0034368)3.84371064
19regulation of cholesterol esterification (GO:0010872)3.84188577
20regulation of plasminogen activation (GO:0010755)3.76175371
21surfactant homeostasis (GO:0043129)3.73384281
22positive regulation of extracellular matrix organization (GO:1903055)3.69096670
23intestinal cholesterol absorption (GO:0030299)3.66987416
24chemical homeostasis within a tissue (GO:0048875)3.58590536
25negative regulation of complement activation (GO:0045916)3.55586677
26cellular response to growth hormone stimulus (GO:0071378)3.45746446
27growth hormone receptor signaling pathway (GO:0060396)3.41782234
28fibrinolysis (GO:0042730)3.29949623
29iron ion import (GO:0097286)3.22466867
30positive regulation by symbiont of host defense response (GO:0052509)3.20772928
31modulation by symbiont of host defense response (GO:0052031)3.20772928
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20772928
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20772928
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.20772928
35modulation by symbiont of host immune response (GO:0052553)3.20772928
36lipoprotein metabolic process (GO:0042157)3.19897385
37acute-phase response (GO:0006953)3.18217152
38positive regulation of natural killer cell differentiation (GO:0032825)3.15605809
39skin morphogenesis (GO:0043589)3.12688994
40blood coagulation, intrinsic pathway (GO:0007597)3.10831063
41positive regulation of bone remodeling (GO:0046852)3.09322555
42positive regulation of bone resorption (GO:0045780)3.09322555
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09286764
44high-density lipoprotein particle remodeling (GO:0034375)3.08598862
45cellular response to interferon-alpha (GO:0035457)3.04411756
46COPII vesicle coating (GO:0048208)3.02108804
47oligosaccharide catabolic process (GO:0009313)3.00452432
48regulation of macrophage chemotaxis (GO:0010758)2.99107691
49hypotonic response (GO:0006971)2.98919372
50hepatocyte apoptotic process (GO:0097284)2.97138284
51regulation of humoral immune response (GO:0002920)2.96077575
52neutrophil activation involved in immune response (GO:0002283)2.95290643
53positive regulation of lipid storage (GO:0010884)2.94725437
54alpha-linolenic acid metabolic process (GO:0036109)2.94619540
55negative regulation of dendrite morphogenesis (GO:0050774)2.93285269
56regulation of heterotypic cell-cell adhesion (GO:0034114)2.92542907
57positive regulation of phagocytosis (GO:0050766)2.90974755
58protein activation cascade (GO:0072376)2.90740957
59regulation of cytokine secretion involved in immune response (GO:0002739)2.89108742
60reverse cholesterol transport (GO:0043691)2.88257172
61regulation of cholesterol storage (GO:0010885)2.87635214
62sterol transport (GO:0015918)2.87428671
63cholesterol transport (GO:0030301)2.87428671
64positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.86854601
65negative regulation of cholesterol transport (GO:0032375)2.85074339
66negative regulation of sterol transport (GO:0032372)2.85074339
67negative regulation of blood coagulation (GO:0030195)2.84590697
68negative regulation of hemostasis (GO:1900047)2.84590697
69positive regulation of interferon-alpha production (GO:0032727)2.83630204
70positive regulation of hormone biosynthetic process (GO:0046886)2.81263475
71positive regulation of cellular amide metabolic process (GO:0034250)2.81015280
72phospholipid efflux (GO:0033700)2.80738370
73complement activation, classical pathway (GO:0006958)2.80148310
74response to manganese ion (GO:0010042)2.80129440
75mammary gland epithelial cell proliferation (GO:0033598)2.78002604
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.77588217
77dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76436214
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.76373390
79negative regulation of coagulation (GO:0050819)2.75077435
80regulation of interferon-alpha production (GO:0032647)2.74537540
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71396092
82negative regulation of humoral immune response (GO:0002921)2.70050825
83negative regulation of wound healing (GO:0061045)2.70049447
84negative regulation of lipid storage (GO:0010888)2.69943470
85positive regulation of steroid metabolic process (GO:0045940)2.68737098
86hydrogen peroxide biosynthetic process (GO:0050665)2.67576890
87positive regulation of fatty acid biosynthetic process (GO:0045723)2.67156246
88positive regulation of blood coagulation (GO:0030194)2.66251816
89positive regulation of hemostasis (GO:1900048)2.66251816
90response to host immune response (GO:0052572)2.66228724
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66228724
92positive regulation of wound healing (GO:0090303)2.66001775
93intestinal absorption (GO:0050892)2.65930021
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64852953
95hyaluronan metabolic process (GO:0030212)2.64325303
96positive regulation vascular endothelial growth factor production (GO:0010575)2.63756564
97macrophage activation involved in immune response (GO:0002281)2.62967697
98COPI coating of Golgi vesicle (GO:0048205)2.62649859
99Golgi transport vesicle coating (GO:0048200)2.62649859
100positive regulation of protein import into nucleus, translocation (GO:0033160)2.61826893
101negative regulation of cell killing (GO:0031342)2.61591773
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61591773
103platelet degranulation (GO:0002576)2.60491622
104regulation of interferon-beta biosynthetic process (GO:0045357)2.58734001
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56974512
106production of molecular mediator involved in inflammatory response (GO:0002532)2.56353149
107peptidyl-glutamic acid carboxylation (GO:0017187)2.56121323
108protein carboxylation (GO:0018214)2.56121323
109osteoclast differentiation (GO:0030316)2.55837393
110complement activation (GO:0006956)2.55117611
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55094373
112basement membrane organization (GO:0071711)2.54732155
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53398283
114regulation of cholesterol biosynthetic process (GO:0045540)2.52854523
115positive regulation of coagulation (GO:0050820)2.52203262
116response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52184766
117response to host (GO:0075136)2.52184766
118response to host defenses (GO:0052200)2.52184766
119positive regulation of lipoprotein lipase activity (GO:0051006)2.52118004
120positive regulation of triglyceride lipase activity (GO:0061365)2.52118004
121regulation of metalloenzyme activity (GO:0048552)2.51797076
122myeloid dendritic cell differentiation (GO:0043011)2.50953723
123regulation of bile acid biosynthetic process (GO:0070857)2.47421674
124nucleobase catabolic process (GO:0046113)2.47105930
125regulation of vascular endothelial growth factor production (GO:0010574)2.46344842
126natural killer cell mediated cytotoxicity (GO:0042267)2.45443411
127natural killer cell mediated immunity (GO:0002228)2.45443411
128nuclear pore complex assembly (GO:0051292)2.45341113
129regulation of acute inflammatory response (GO:0002673)2.44804053
130regulation of extracellular matrix organization (GO:1903053)2.43964997
131positive regulation of macrophage differentiation (GO:0045651)2.41234952
132low-density lipoprotein particle clearance (GO:0034383)2.40641994
133endodermal cell differentiation (GO:0035987)2.40621954
134positive regulation of transforming growth factor beta production (GO:0071636)2.40004091
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.39513896
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38353861
137regulation of transforming growth factor beta1 production (GO:0032908)2.35763276
138estrogen biosynthetic process (GO:0006703)2.35349950
139lung lobe morphogenesis (GO:0060463)2.34864268
140response to growth hormone (GO:0060416)2.34699842
141substrate-dependent cell migration (GO:0006929)2.34395872
142complement activation, alternative pathway (GO:0006957)2.34165844
143cellular response to antibiotic (GO:0071236)2.33348307
144phagosome maturation (GO:0090382)2.32737331
145antigen processing and presentation of endogenous antigen (GO:0019883)2.32328486
146regulation of membrane protein ectodomain proteolysis (GO:0051043)2.29424587
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29310016
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29310016
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29005642
150ferric iron transport (GO:0015682)2.28715429
151trivalent inorganic cation transport (GO:0072512)2.28715429
152detection of molecule of bacterial origin (GO:0032490)2.28077172
153cellular response to ethanol (GO:0071361)2.27538763
154urea cycle (GO:0000050)2.27314705
155urea metabolic process (GO:0019627)2.27314705
156apoptotic cell clearance (GO:0043277)2.27298475
157clathrin coat assembly (GO:0048268)2.26688305
158positive regulation of macrophage cytokine production (GO:0060907)2.25849446
159regulation of natural killer cell differentiation (GO:0032823)2.22190062
160response to xenobiotic stimulus (GO:0009410)2.22056054
161phenylpropanoid metabolic process (GO:0009698)2.21088424
162I-kappaB phosphorylation (GO:0007252)2.19996027
163positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.18225305
164transferrin transport (GO:0033572)2.17969486
165positive regulation of interferon-beta production (GO:0032728)2.17652958
166regulation of protein activation cascade (GO:2000257)2.17495781
167NLS-bearing protein import into nucleus (GO:0006607)2.16996046
168regulation of oxidative stress-induced neuron death (GO:1903203)2.16588817
169positive regulation of nitric-oxide synthase activity (GO:0051000)2.16581508
170reactive oxygen species biosynthetic process (GO:1903409)2.15940016
171epoxygenase P450 pathway (GO:0019373)2.15876567
172type B pancreatic cell proliferation (GO:0044342)2.15332046
173axon extension (GO:0048675)2.14500330
174macrophage activation (GO:0042116)2.12681445
175regulation of complement activation (GO:0030449)2.11968702
176protein localization to microtubule (GO:0035372)2.11118781
177regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10628579
178regulation of alkaline phosphatase activity (GO:0010692)2.10626962
179protein localization to endosome (GO:0036010)2.08636975
180cholesterol efflux (GO:0033344)2.08435122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.01576796
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70940331
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34057072
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.32881754
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.19789629
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.03397196
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.91343258
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.83020563
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61200263
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50632882
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.48500857
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.46038242
13CLOCK_20551151_ChIP-Seq_293T_Human2.39200045
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34274898
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31122857
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29175362
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.28981377
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28336671
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20294002
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17249299
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12030743
22NRF2_20460467_ChIP-Seq_MEFs_Mouse2.07529415
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.07529415
24ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03502201
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95587992
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.90592155
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89525499
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.89390493
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.88705299
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.86908369
31AR_21909140_ChIP-Seq_LNCAP_Human1.86462356
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83217591
33ZNF263_19887448_ChIP-Seq_K562_Human1.81845626
34CJUN_26792858_Chip-Seq_BT549_Human1.78037834
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68590672
36AHR_22903824_ChIP-Seq_MCF-7_Human1.67246334
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66588486
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66588486
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65768955
40SOX2_20726797_ChIP-Seq_SW620_Human1.64416053
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63567237
42* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63565699
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63249731
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62041712
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58791480
46RXR_22108803_ChIP-Seq_LS180_Human1.57864804
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.57032249
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55228241
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54898416
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53850148
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.52102978
52TP53_18474530_ChIP-ChIP_U2OS_Human1.51949346
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51505364
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51064477
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47426747
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47335994
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45541535
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41427220
59VDR_24787735_ChIP-Seq_THP-1_Human1.40054027
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.39215953
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37298921
62GATA1_22025678_ChIP-Seq_K562_Human1.37218107
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.36663990
64RUNX_20019798_ChIP-Seq_JUKART_Human1.35517744
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34269452
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34245481
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.34119543
68BRD4_25478319_ChIP-Seq_HGPS_Human1.33933717
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.30578159
70* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30313182
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29695429
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28797687
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.28057153
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27864515
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26362925
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26143247
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.24858760
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.22538418
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20630227
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20597764
81AR_21572438_ChIP-Seq_LNCaP_Human1.19488908
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18740247
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.18541945
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16884437
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15259279
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14597305
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14406440
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13647362
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13411901
90TAF15_26573619_Chip-Seq_HEK293_Human1.11800333
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11751107
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11586372
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09208762
94* TP63_23658742_ChIP-Seq_EP156T_Human1.08653212
95TP53_16413492_ChIP-PET_HCT116_Human1.08516314
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08382018
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07360398
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.07048846
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06703461
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06454244
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05647204
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05639655
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05126508
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03150015
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02299543
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01503999
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01495729
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01044883
109SMAD4_21799915_ChIP-Seq_A2780_Human1.00569655
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99527416
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98547420
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98047682
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97616911
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97351585
115PU_27001747_Chip-Seq_BMDM_Mouse0.97057279
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96204615
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95762013
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95411283
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95329019
120MYB_26560356_Chip-Seq_TH2_Human0.95308360
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95097111
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94869726
123AR_25329375_ChIP-Seq_VCAP_Human0.94569735
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93667525
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.92318211
126* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91801463
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90657798
128* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87766920
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87292117
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86627430
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85952068
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82948343
133SPI1_23127762_ChIP-Seq_K562_Human0.82704691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog3.56703808
2MP0010234_abnormal_vibrissa_follicle3.08447983
3MP0003303_peritoneal_inflammation2.90969332
4MP0005451_abnormal_body_composition2.85077508
5MP0002138_abnormal_hepatobiliary_system2.62482868
6MP0003950_abnormal_plasma_membrane2.58270490
7MP0003300_gastrointestinal_ulcer2.54889603
8MP0003436_decreased_susceptibility_to2.50654046
9MP0003122_maternal_imprinting2.40837343
10MP0001835_abnormal_antigen_presentation2.38589326
11MP0001881_abnormal_mammary_gland2.37297104
12MP0002139_abnormal_hepatobiliary_system2.34502019
13MP0003705_abnormal_hypodermis_morpholog2.29895758
14MP0003724_increased_susceptibility_to2.28849163
15MP0010352_gastrointestinal_tract_polyps2.20593529
16MP0004272_abnormal_basement_membrane2.17060626
17MP0003195_calcinosis2.16726306
18MP0001915_intracranial_hemorrhage2.11635684
19MP0002877_abnormal_melanocyte_morpholog2.10976099
20MP0009785_altered_susceptibility_to1.86851299
21MP0003191_abnormal_cellular_cholesterol1.85321344
22MP0000604_amyloidosis1.84022199
23MP0000569_abnormal_digit_pigmentation1.83462375
24MP0005083_abnormal_biliary_tract1.81894344
25MP0000627_abnormal_mammary_gland1.80199301
26MP0005085_abnormal_gallbladder_physiolo1.78236674
27MP0005257_abnormal_intraocular_pressure1.75945613
28MP0005076_abnormal_cell_differentiation1.75854170
29MP0006082_CNS_inflammation1.72475939
30MP0002419_abnormal_innate_immunity1.69689926
31MP0002148_abnormal_hypersensitivity_rea1.66473732
32MP0002166_altered_tumor_susceptibility1.63315873
33MP0005164_abnormal_response_to1.60348281
34MP0001533_abnormal_skeleton_physiology1.60200063
35MP0001958_emphysema1.60130022
36MP0004947_skin_inflammation1.58875856
37MP0003091_abnormal_cell_migration1.53585439
38MP0005387_immune_system_phenotype1.53521197
39MP0001790_abnormal_immune_system1.53521197
40MP0005058_abnormal_lysosome_morphology1.50136308
41MP0002006_tumorigenesis1.49571453
42MP0003868_abnormal_feces_composition1.48995239
43MP0009780_abnormal_chondrocyte_physiolo1.48310352
44MP0003566_abnormal_cell_adhesion1.48002341
45MP0005409_darkened_coat_color1.47471404
46MP0001177_atelectasis1.45422612
47MP0008260_abnormal_autophagy1.43193092
48MP0004883_abnormal_blood_vessel1.41003820
49MP0005166_decreased_susceptibility_to1.39025100
50MP0005464_abnormal_platelet_physiology1.38965648
51MP0005000_abnormal_immune_tolerance1.38822354
52MP0003448_altered_tumor_morphology1.38723524
53MP0000858_altered_metastatic_potential1.38418703
54MP0001666_abnormal_nutrient_absorption1.32953333
55MP0005167_abnormal_blood-brain_barrier1.32527929
56MP0009764_decreased_sensitivity_to1.31371049
57MP0004858_abnormal_nervous_system1.30194748
58MP0008438_abnormal_cutaneous_collagen1.29266705
59MP0010307_abnormal_tumor_latency1.27903856
60MP0002452_abnormal_antigen_presenting1.26161906
61MP0003075_altered_response_to1.25754087
62MP0005025_abnormal_response_to1.23659458
63MP0002089_abnormal_postnatal_growth/wei1.22651078
64MP0000767_abnormal_smooth_muscle1.21495829
65MP0002876_abnormal_thyroid_physiology1.17626235
66MP0003045_fibrosis1.17236910
67MP0002168_other_aberrant_phenotype1.17137166
68MP0002998_abnormal_bone_remodeling1.16002967
69MP0003252_abnormal_bile_duct1.14992035
70MP0002254_reproductive_system_inflammat1.14865337
71MP0002896_abnormal_bone_mineralization1.12959445
72MP0005360_urolithiasis1.12567750
73MP0010329_abnormal_lipoprotein_level1.12167026
74MP0005023_abnormal_wound_healing1.11399369
75MP0003221_abnormal_cardiomyocyte_apopto1.10913085
76MP0003453_abnormal_keratinocyte_physiol1.08471060
77MP0001845_abnormal_inflammatory_respons1.08456043
78MP0005408_hypopigmentation1.07539086
79MP0008875_abnormal_xenobiotic_pharmacok1.07196994
80MP0002933_joint_inflammation1.07143192
81MP0002009_preneoplasia1.06592587
82MP0005623_abnormal_meninges_morphology1.06590690
83MP0003690_abnormal_glial_cell1.05573195
84MP0010368_abnormal_lymphatic_system1.04796342
85MP0000920_abnormal_myelination1.04695908
86MP0002295_abnormal_pulmonary_circulatio1.04561982
87MP0003828_pulmonary_edema1.03619097
88MP0002723_abnormal_immune_serum1.03388564
89MP0001800_abnormal_humoral_immune1.01601582
90MP0003123_paternal_imprinting1.01058093
91MP0008469_abnormal_protein_level0.99954729
92MP0001542_abnormal_bone_strength0.99617628
93MP0002909_abnormal_adrenal_gland0.99268625
94MP0005671_abnormal_response_to0.98322405
95MP0004130_abnormal_muscle_cell0.97173877
96MP0005365_abnormal_bile_salt0.96432497
97MP0009053_abnormal_anal_canal0.96073988
98MP0005248_abnormal_Harderian_gland0.95014196
99MP0000609_abnormal_liver_physiology0.94033987
100MP0001819_abnormal_immune_cell0.92806478
101MP0001853_heart_inflammation0.91928983
102MP0010155_abnormal_intestine_physiology0.91693366
103MP0006054_spinal_hemorrhage0.90680271
104MP0002420_abnormal_adaptive_immunity0.90637312
105MP0004510_myositis0.89473713
106MP0002405_respiratory_system_inflammati0.89285149
107MP0000685_abnormal_immune_system0.88949602
108MP0005310_abnormal_salivary_gland0.88899484
109MP0000343_altered_response_to0.88853549
110MP0009840_abnormal_foam_cell0.88288608
111MP0005388_respiratory_system_phenotype0.87309517
112MP0002133_abnormal_respiratory_system0.87309517
113MP0001661_extended_life_span0.86497557
114MP0008004_abnormal_stomach_pH0.85848646
115MP0005319_abnormal_enzyme/_coenzyme0.82266977
116MP0009763_increased_sensitivity_to0.81685893
117MP0003941_abnormal_skin_development0.81155373
118MP0003279_aneurysm0.81099246
119MP0003172_abnormal_lysosome_physiology0.80597150
120MP0005275_abnormal_skin_tensile0.79891144
121MP0000249_abnormal_blood_vessel0.79596693
122MP0001879_abnormal_lymphatic_vessel0.79139091
123* MP0002118_abnormal_lipid_homeostasis0.78965014
124MP0001348_abnormal_lacrimal_gland0.77748488
125MP0003656_abnormal_erythrocyte_physiolo0.77747377
126MP0001851_eye_inflammation0.75873805
127MP0003329_amyloid_beta_deposits0.74978629
128MP0000371_diluted_coat_color0.74959399
129MP0004185_abnormal_adipocyte_glucose0.74872320
130MP0004270_analgesia0.74457446
131MP0000598_abnormal_liver_morphology0.73099288
132MP0002971_abnormal_brown_adipose0.72024995
133MP0004233_abnormal_muscle_weight0.71717887
134MP0009384_cardiac_valve_regurgitation0.71588161
135MP0003183_abnormal_peptide_metabolism0.70433028
136MP0003632_abnormal_nervous_system0.70408930
137MP0002086_abnormal_extraembryonic_tissu0.67291901
138MP0005165_increased_susceptibility_to0.66936372
139MP0005621_abnormal_cell_physiology0.65145224

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)5.35007354
2Prolonged partial thromboplastin time (HP:0003645)3.84070232
3Osteolytic defects of the hand bones (HP:0009699)3.69834847
4Osteolytic defects of the phalanges of the hand (HP:0009771)3.69834847
5Recurrent gram-negative bacterial infections (HP:0005420)3.53349650
6Eczematoid dermatitis (HP:0000976)3.40992234
7Hypobetalipoproteinemia (HP:0003563)3.37744038
8Alveolar cell carcinoma (HP:0006519)3.36275606
9Myocardial infarction (HP:0001658)3.33978282
10Hypercholesterolemia (HP:0003124)3.20565113
11Subacute progressive viral hepatitis (HP:0006572)3.17050021
12Protrusio acetabuli (HP:0003179)3.13838516
13Menorrhagia (HP:0000132)3.06371036
14Disinhibition (HP:0000734)3.03765717
15Neoplasm of the tracheobronchial system (HP:0100552)3.03235204
16Complement deficiency (HP:0004431)2.91685223
17Abnormality of carpal bone ossification (HP:0006257)2.90722908
18Gingival bleeding (HP:0000225)2.89363339
19Recurrent bacterial skin infections (HP:0005406)2.85816490
20Recurrent abscess formation (HP:0002722)2.78757076
21Scanning speech (HP:0002168)2.71336429
22Flat acetabular roof (HP:0003180)2.70080229
23Nephritis (HP:0000123)2.69454503
24Abnormality of complement system (HP:0005339)2.65137709
25Skin nodule (HP:0200036)2.63822454
26Mutism (HP:0002300)2.63793596
27Premature rupture of membranes (HP:0001788)2.63211255
28Small epiphyses (HP:0010585)2.61301506
29Hypolipoproteinemia (HP:0010981)2.55721233
30Myositis (HP:0100614)2.50549938
31Hematochezia (HP:0002573)2.46830342
32Cardiovascular calcification (HP:0011915)2.43723110
33Abnormality of the lumbar spine (HP:0100712)2.42776483
34Orchitis (HP:0100796)2.41412673
35Arterial thrombosis (HP:0004420)2.40307008
36Deep venous thrombosis (HP:0002625)2.40283778
37Abnormality of the common coagulation pathway (HP:0010990)2.40101636
38Systemic lupus erythematosus (HP:0002725)2.39086085
39Vascular calcification (HP:0004934)2.38088042
40Hemorrhage of the eye (HP:0011885)2.37827676
41Purpura (HP:0000979)2.37518081
42Pustule (HP:0200039)2.37136286
43Abnormal ossification of hand bones (HP:0005921)2.32795562
44Thick nail (HP:0001805)2.30243406
45Neurofibrillary tangles (HP:0002185)2.29333350
46Acanthocytosis (HP:0001927)2.28248463
47Epidermoid cyst (HP:0200040)2.27967682
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27262707
49Increased cerebral lipofuscin (HP:0011813)2.26769714
50Flared iliac wings (HP:0002869)2.26425635
51Esophageal varix (HP:0002040)2.25952208
52Absent frontal sinuses (HP:0002688)2.25299559
53Autoimmune thrombocytopenia (HP:0001973)2.22960278
54Inappropriate behavior (HP:0000719)2.20870479
55Retrobulbar optic neuritis (HP:0100654)2.20269834
56Optic neuritis (HP:0100653)2.20269834
57Tetraparesis (HP:0002273)2.18934250
58Broad palm (HP:0001169)2.18531511
59Mitral stenosis (HP:0001718)2.17887162
60Abnormality of glycolipid metabolism (HP:0010969)2.17481309
61Abnormality of liposaccharide metabolism (HP:0010968)2.17481309
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.17481309
63Short nail (HP:0001799)2.16646324
64Amyloidosis (HP:0011034)2.16470613
65Gout (HP:0001997)2.14979259
66Stomach cancer (HP:0012126)2.13306982
67Peritonitis (HP:0002586)2.12798215
68Mediastinal lymphadenopathy (HP:0100721)2.12338901
69Tubulointerstitial fibrosis (HP:0005576)2.12240103
70Papilledema (HP:0001085)2.10304955
71Enlarged penis (HP:0000040)2.09938190
72Curly hair (HP:0002212)2.08774113
73Abnormal hand bone ossification (HP:0010660)2.07243999
74Mucopolysacchariduria (HP:0008155)2.06772375
75Urinary glycosaminoglycan excretion (HP:0003541)2.06772375
76Bilateral sensorineural hearing impairment (HP:0008619)2.06731240
77Papillary thyroid carcinoma (HP:0002895)2.04042046
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.02797143
79Glomerulonephritis (HP:0000099)2.02280594
80Osteomyelitis (HP:0002754)2.01715475
81Abnormality of the Achilles tendon (HP:0005109)2.01589611
82Spinal cord lesions (HP:0100561)2.01464899
83Syringomyelia (HP:0003396)2.01464899
84Joint swelling (HP:0001386)2.01222889
85Abnormal foot bone ossification (HP:0010675)2.00333887
86Abnormality of macrophages (HP:0004311)1.98601312
87Periodontitis (HP:0000704)1.98344438
88Cupped ribs (HP:0000887)1.98231332
89Abnormality of the peritoneum (HP:0002585)1.98174204
90Abnormality of the intrinsic pathway (HP:0010989)1.97335909
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96305361
92Focal segmental glomerulosclerosis (HP:0000097)1.95933122
93Abnormality of the acetabulum (HP:0003170)1.95623494
94Abnormal tarsal ossification (HP:0008369)1.95409065
95Cerebral aneurysm (HP:0004944)1.95337028
96Epiphyseal dysplasia (HP:0002656)1.94995752
97Delayed closure of the anterior fontanelle (HP:0001476)1.93991608
98Xanthomatosis (HP:0000991)1.93850771
99Dysostosis multiplex (HP:0000943)1.93832734
100Cutaneous melanoma (HP:0012056)1.92479168
101Hypoalphalipoproteinemia (HP:0003233)1.91207025
102Aortic dissection (HP:0002647)1.90416476
103Arterial tortuosity (HP:0005116)1.90178179
104Conjugated hyperbilirubinemia (HP:0002908)1.89725956
105Diminished motivation (HP:0000745)1.89426189
106Prostate neoplasm (HP:0100787)1.88700515
107Cortical dysplasia (HP:0002539)1.87883642
108Apathy (HP:0000741)1.85193091
109Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84192928
110Thrombophlebitis (HP:0004418)1.84164852
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83627815
112Abnormality of polysaccharide metabolism (HP:0011012)1.83627815
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83627815
114Orthostatic hypotension (HP:0001278)1.83317001
115Hepatocellular carcinoma (HP:0001402)1.82662723
116Metaphyseal irregularity (HP:0003025)1.82578369
117Glomerulosclerosis (HP:0000096)1.80314727
118Vertebral compression fractures (HP:0002953)1.79550518
119Wormian bones (HP:0002645)1.79266617
120Broad alveolar ridges (HP:0000187)1.79239251
121Ovoid vertebral bodies (HP:0003300)1.79029542
122Vacuolated lymphocytes (HP:0001922)1.78889854
123Epistaxis (HP:0000421)1.78220682
124Upper motor neuron abnormality (HP:0002127)1.77325354
125Conjunctival telangiectasia (HP:0000524)1.75889689
126Polycythemia (HP:0001901)1.75003837
127Coarse hair (HP:0002208)1.74760360
128Abnormal delivery (HP:0001787)1.74692054
129Striae distensae (HP:0001065)1.73823517
130Intrahepatic cholestasis (HP:0001406)1.73330983
131Lower limb amyotrophy (HP:0007210)1.73312392
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72050446
133Abnormality of the wing of the ilium (HP:0011867)1.71369009
134Viral hepatitis (HP:0006562)1.70874481
135Bone pain (HP:0002653)1.70791645
136Aortic aneurysm (HP:0004942)1.70592204
137Micronodular cirrhosis (HP:0001413)1.70259865
138Gingivitis (HP:0000230)1.68276973
139Spontaneous abortion (HP:0005268)1.67821822
140Cervical subluxation (HP:0003308)1.67386536
141Vascular tortuosity (HP:0004948)1.66801630
142Gastrointestinal infarctions (HP:0005244)1.65964130
143Alopecia of scalp (HP:0002293)1.65630366
144Long toe (HP:0010511)1.64172307
145Increased mean platelet volume (HP:0011877)1.64024469
146Pathologic fracture (HP:0002756)1.63844935
147Asymmetry of the thorax (HP:0001555)1.61514882
148Abnormality of the pericardium (HP:0001697)1.61425858
149Cerebral inclusion bodies (HP:0100314)1.61061636
150Keratoconjunctivitis sicca (HP:0001097)1.60755840
151Akinesia (HP:0002304)1.58861871
152Anorexia (HP:0002039)1.58351409
153Camptodactyly of toe (HP:0001836)1.58344962
154Elevated erythrocyte sedimentation rate (HP:0003565)1.57980833
155Joint hemorrhage (HP:0005261)1.57288552
156Acrocyanosis (HP:0001063)1.57212778
157Mucosal telangiectasiae (HP:0100579)1.57066665
158Abnormal cortical bone morphology (HP:0003103)1.56973102
159Overgrowth (HP:0001548)1.56757781
160Aqueductal stenosis (HP:0002410)1.56704518
161Abnormality of pain sensation (HP:0010832)1.55880557
162Impaired pain sensation (HP:0007328)1.55880557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.01395443
2MAP3K143.23942449
3FRK2.94364643
4BMPR22.75107367
5PLK22.68246879
6ICK2.56988566
7ERBB32.49190542
8DDR22.44341533
9SCYL22.43065494
10NEK92.27579306
11CASK2.18901077
12PRPF4B2.18444716
13RIPK42.18145152
14MAP3K92.15771876
15DAPK22.15756206
16FGFR32.10541479
17STK242.05150886
18JAK32.00784990
19CDK121.92878967
20FGR1.77515076
21FER1.69204398
22AKT31.67471280
23MST41.61108083
24STK31.60510638
25WNK11.54426481
26EPHA21.53580713
27MAP3K21.50073867
28SGK31.48945236
29SGK21.47246695
30MST1R1.46229518
31FGFR41.46159086
32MATK1.41224117
33LATS11.38158627
34CDK61.37852936
35JAK11.36643595
36ZAP701.35668420
37MAP2K31.34437690
38LATS21.32917706
39TYRO31.31599331
40TRPM71.30865945
41SIK11.26427385
42EPHA31.21862938
43NUAK11.21551257
44TAOK21.21070842
45NTRK11.21048729
46CDC42BPA1.20703191
47MAP3K61.20491253
48PLK31.16858077
49TBK11.09476956
50CHUK1.08048408
51CSK1.06349060
52MAP3K121.03287640
53MARK11.03150554
54MINK11.01903930
55EIF2AK11.00884743
56TXK0.98954308
57TYK20.98170291
58PKN20.93364152
59EIF2AK30.92480478
60WNK40.91138159
61SIK30.90767744
62TGFBR20.89802060
63PDPK10.88955324
64IKBKB0.88630063
65JAK20.87075840
66MAP2K10.86920510
67PDGFRB0.86898965
68EPHB20.86636062
69EGFR0.86256637
70STK100.86175671
71MAP3K30.85988856
72MOS0.84527601
73BMX0.83968508
74YES10.83849220
75MAP3K10.83300583
76ERN10.81516518
77FGFR20.79871331
78PTK20.78259989
79LRRK20.78033623
80MELK0.77331748
81CAMK1D0.75972278
82PAK40.75372102
83IKBKE0.73594030
84BLK0.72529231
85GSK3A0.72225370
86FGFR10.71095784
87ARAF0.71041653
88RET0.70841921
89PRKAA20.70583043
90PIK3CA0.69318492
91PIM20.68953316
92ERBB40.68746688
93KSR20.67994291
94MET0.67761215
95RPS6KA20.66605423
96DAPK10.65964693
97BCR0.65958698
98EEF2K0.65758055
99PDK10.65178446
100CAMK1G0.64735874
101PAK20.63402394
102MAP3K130.62352229
103PAK30.61541142
104SGK2230.60411552
105SGK4940.60411552
106RIPK10.59834763
107CLK10.58993780
108PDK20.57464542
109CAMKK20.57422390
110CSNK1G20.57086713
111PTK60.56597614
112STK38L0.53503621
113PRKCH0.52536470
114BRD40.51479914
115IRAK40.51404115
116ALK0.51341353
117MAPK110.51148360
118CCNB10.49811335
119CAMKK10.49029779
120CSF1R0.48825699
121MAP3K50.48699597
122EPHB10.48434783
123CSNK1A1L0.47237973
124KSR10.45719802
125ITK0.44711138
126MAP2K40.44660287
127FLT30.43948819
128GRK70.43754425
129EIF2AK20.43473211
130IGF1R0.42687997
131MAP3K80.42512776
132BRSK20.42339481
133PIM10.41572291
134NEK10.41521616
135TRIB30.41291500
136TTN0.40856238
137PRKCE0.40361896
138PDGFRA0.40189257
139SYK0.39010344
140ABL10.38864822
141MTOR0.38284905
142RAF10.37012691
143DYRK1B0.36863867
144INSR0.34420684
145CDK40.31833419

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.93797770
2Other glycan degradation_Homo sapiens_hsa005112.41396761
3Rheumatoid arthritis_Homo sapiens_hsa053232.10379719
4Staphylococcus aureus infection_Homo sapiens_hsa051502.10170414
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.98333008
6Phagosome_Homo sapiens_hsa041451.90940206
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82449471
8Graft-versus-host disease_Homo sapiens_hsa053321.79598069
9Leishmaniasis_Homo sapiens_hsa051401.78886744
10Complement and coagulation cascades_Homo sapiens_hsa046101.61206992
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60890733
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58517229
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.56516761
14Collecting duct acid secretion_Homo sapiens_hsa049661.51363779
15Tuberculosis_Homo sapiens_hsa051521.50519946
16Pertussis_Homo sapiens_hsa051331.50255206
17Legionellosis_Homo sapiens_hsa051341.44949264
18Malaria_Homo sapiens_hsa051441.44529629
19Prolactin signaling pathway_Homo sapiens_hsa049171.44284038
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42782641
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39206574
22TNF signaling pathway_Homo sapiens_hsa046681.39027833
23Pancreatic cancer_Homo sapiens_hsa052121.38137791
24Allograft rejection_Homo sapiens_hsa053301.34351232
25Prion diseases_Homo sapiens_hsa050201.31401805
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30987458
27Steroid biosynthesis_Homo sapiens_hsa001001.29514519
28Toxoplasmosis_Homo sapiens_hsa051451.27692962
29Caffeine metabolism_Homo sapiens_hsa002321.26017275
30Synaptic vesicle cycle_Homo sapiens_hsa047211.25668585
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22887249
32Amoebiasis_Homo sapiens_hsa051461.22335718
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22242623
34Osteoclast differentiation_Homo sapiens_hsa043801.22115500
35* PPAR signaling pathway_Homo sapiens_hsa033201.19828429
36Endometrial cancer_Homo sapiens_hsa052131.19252140
37Lysosome_Homo sapiens_hsa041421.18207253
38Salmonella infection_Homo sapiens_hsa051321.17595974
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17353425
40Type I diabetes mellitus_Homo sapiens_hsa049401.16767857
41Starch and sucrose metabolism_Homo sapiens_hsa005001.12463249
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.10144126
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08407227
44Galactose metabolism_Homo sapiens_hsa000521.06717619
45Measles_Homo sapiens_hsa051621.04954526
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04602080
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03173954
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01112220
49Adherens junction_Homo sapiens_hsa045201.01098378
50Hepatitis B_Homo sapiens_hsa051611.00946419
51Vibrio cholerae infection_Homo sapiens_hsa051100.99991593
52Viral myocarditis_Homo sapiens_hsa054160.99117107
53Antigen processing and presentation_Homo sapiens_hsa046120.95625073
54Fat digestion and absorption_Homo sapiens_hsa049750.94063654
55Hepatitis C_Homo sapiens_hsa051600.93990929
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.93379244
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93101613
58Apoptosis_Homo sapiens_hsa042100.92846718
59Chronic myeloid leukemia_Homo sapiens_hsa052200.91825460
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90001818
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.85233998
62Glioma_Homo sapiens_hsa052140.85011701
63Proteoglycans in cancer_Homo sapiens_hsa052050.84614961
64Chemokine signaling pathway_Homo sapiens_hsa040620.84239311
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84007841
66Influenza A_Homo sapiens_hsa051640.83683448
67African trypanosomiasis_Homo sapiens_hsa051430.82424264
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.82388073
69Bladder cancer_Homo sapiens_hsa052190.81537592
70Autoimmune thyroid disease_Homo sapiens_hsa053200.80741829
71Prostate cancer_Homo sapiens_hsa052150.79228359
72T cell receptor signaling pathway_Homo sapiens_hsa046600.79206001
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.78881870
74FoxO signaling pathway_Homo sapiens_hsa040680.78126791
75Dorso-ventral axis formation_Homo sapiens_hsa043200.78123075
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.77768077
77Ovarian steroidogenesis_Homo sapiens_hsa049130.77485406
78Focal adhesion_Homo sapiens_hsa045100.76026956
79Shigellosis_Homo sapiens_hsa051310.75099923
80* Adipocytokine signaling pathway_Homo sapiens_hsa049200.74909056
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74061636
82B cell receptor signaling pathway_Homo sapiens_hsa046620.73422983
83ErbB signaling pathway_Homo sapiens_hsa040120.72737190
84Small cell lung cancer_Homo sapiens_hsa052220.72098255
85* Fatty acid biosynthesis_Homo sapiens_hsa000610.72069220
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70384344
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69984343
88Arginine biosynthesis_Homo sapiens_hsa002200.68300289
89Renal cell carcinoma_Homo sapiens_hsa052110.67763034
90N-Glycan biosynthesis_Homo sapiens_hsa005100.66431386
91Vitamin digestion and absorption_Homo sapiens_hsa049770.64639265
92Sphingolipid metabolism_Homo sapiens_hsa006000.64620983
93HIF-1 signaling pathway_Homo sapiens_hsa040660.63779505
94Thyroid cancer_Homo sapiens_hsa052160.62951199
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62789482
96Non-small cell lung cancer_Homo sapiens_hsa052230.62511243
97Insulin signaling pathway_Homo sapiens_hsa049100.59637990
98Thyroid hormone synthesis_Homo sapiens_hsa049180.59212799
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58694174
100Colorectal cancer_Homo sapiens_hsa052100.57470085
101ECM-receptor interaction_Homo sapiens_hsa045120.57313570
102MicroRNAs in cancer_Homo sapiens_hsa052060.56612486
103VEGF signaling pathway_Homo sapiens_hsa043700.56179729
104Acute myeloid leukemia_Homo sapiens_hsa052210.55658673
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55543524
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.55207099
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55007456
108mTOR signaling pathway_Homo sapiens_hsa041500.54613039
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54446494
110Mineral absorption_Homo sapiens_hsa049780.53746299
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.53652189
112* Fatty acid metabolism_Homo sapiens_hsa012120.53627214
113Long-term potentiation_Homo sapiens_hsa047200.52255646
114Fructose and mannose metabolism_Homo sapiens_hsa000510.51624579
115Hematopoietic cell lineage_Homo sapiens_hsa046400.51164914
116Insulin resistance_Homo sapiens_hsa049310.49218380
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48928484
118Melanoma_Homo sapiens_hsa052180.48525631
119Platelet activation_Homo sapiens_hsa046110.47918652
120Asthma_Homo sapiens_hsa053100.45845190
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44650246
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44339181
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43720874
124Bile secretion_Homo sapiens_hsa049760.43675765
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42587582
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41603752
127Renin-angiotensin system_Homo sapiens_hsa046140.41432088
128Inositol phosphate metabolism_Homo sapiens_hsa005620.40866358
129Viral carcinogenesis_Homo sapiens_hsa052030.40610121

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