ACRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.72897654
2synapsis (GO:0007129)5.93214463
3male meiosis I (GO:0007141)5.64721097
4cell wall macromolecule catabolic process (GO:0016998)5.23294246
5male meiosis (GO:0007140)4.86536887
6DNA methylation involved in gamete generation (GO:0043046)4.72074074
7meiosis I (GO:0007127)4.68704878
8cell wall macromolecule metabolic process (GO:0044036)4.51915428
9regulation of MHC class II biosynthetic process (GO:0045346)4.17581817
10chromosome organization involved in meiosis (GO:0070192)3.92928340
11behavioral response to nicotine (GO:0035095)3.91988097
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78952949
13reciprocal meiotic recombination (GO:0007131)3.76442674
14reciprocal DNA recombination (GO:0035825)3.76442674
15organelle membrane fusion (GO:0090174)3.67403002
16myelin assembly (GO:0032288)3.64891854
17resolution of meiotic recombination intermediates (GO:0000712)3.63009904
18regulation of cilium movement (GO:0003352)3.61157267
19meiotic nuclear division (GO:0007126)3.59665959
20negative regulation of response to food (GO:0032096)3.57059930
21negative regulation of appetite (GO:0032099)3.57059930
22protein K11-linked deubiquitination (GO:0035871)3.56745164
23interkinetic nuclear migration (GO:0022027)3.50084959
24negative regulation of telomere maintenance (GO:0032205)3.48955788
25DNA deamination (GO:0045006)3.44426210
26indolalkylamine metabolic process (GO:0006586)3.40566127
27autophagic vacuole fusion (GO:0000046)3.33386725
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24949016
29retinal rod cell development (GO:0046548)3.24654736
30detection of light stimulus involved in visual perception (GO:0050908)3.17040198
31detection of light stimulus involved in sensory perception (GO:0050962)3.17040198
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14983812
33nonmotile primary cilium assembly (GO:0035058)3.14187948
34regulation of meiosis I (GO:0060631)3.14082747
35response to pheromone (GO:0019236)3.10758718
36neuron fate determination (GO:0048664)3.08187181
37brain morphogenesis (GO:0048854)3.03569072
38photoreceptor cell maintenance (GO:0045494)3.03028038
39meiotic cell cycle process (GO:1903046)3.01386929
40negative regulation of systemic arterial blood pressure (GO:0003085)2.98572943
41synaptonemal complex organization (GO:0070193)2.97853607
42negative regulation of alpha-beta T cell differentiation (GO:0046639)2.96335016
43negative regulation of execution phase of apoptosis (GO:1900118)2.94073874
44synaptonemal complex assembly (GO:0007130)2.93012996
45cilium morphogenesis (GO:0060271)2.88517024
46epithelial cilium movement (GO:0003351)2.87231439
47axoneme assembly (GO:0035082)2.80022939
48prenylation (GO:0097354)2.78137903
49protein prenylation (GO:0018342)2.78137903
50regulation of microtubule-based movement (GO:0060632)2.77716056
51neural tube formation (GO:0001841)2.77113916
52kidney morphogenesis (GO:0060993)2.75453981
53auditory receptor cell differentiation (GO:0042491)2.75448486
54meiotic chromosome segregation (GO:0045132)2.73750373
55rRNA catabolic process (GO:0016075)2.70070823
56L-fucose catabolic process (GO:0042355)2.69912313
57fucose catabolic process (GO:0019317)2.69912313
58L-fucose metabolic process (GO:0042354)2.69912313
59recombinational repair (GO:0000725)2.68666705
60negative regulation by host of viral transcription (GO:0043922)2.67810900
61negative regulation of alpha-beta T cell activation (GO:0046636)2.66923439
62auditory receptor cell stereocilium organization (GO:0060088)2.65833255
63multicellular organism reproduction (GO:0032504)2.65788026
64double-strand break repair via homologous recombination (GO:0000724)2.65254915
65retinal cone cell development (GO:0046549)2.64667974
66negative regulation of DNA-dependent DNA replication (GO:2000104)2.63069833
67microtubule anchoring (GO:0034453)2.61190634
68negative regulation of T-helper cell differentiation (GO:0045623)2.61122677
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61122677
70photoreceptor cell development (GO:0042461)2.57518661
71pyrimidine ribonucleoside catabolic process (GO:0046133)2.56438368
72somite rostral/caudal axis specification (GO:0032525)2.53919901
73negative T cell selection (GO:0043383)2.53200283
74adenosine metabolic process (GO:0046085)2.50135158
75indole-containing compound metabolic process (GO:0042430)2.48638943
76positive regulation of defense response to virus by host (GO:0002230)2.48219108
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47612236
78sister chromatid cohesion (GO:0007062)2.47545740
79centriole replication (GO:0007099)2.47180792
80adaptation of signaling pathway (GO:0023058)2.46841646
81DNA synthesis involved in DNA repair (GO:0000731)2.45825661
82establishment of protein localization to Golgi (GO:0072600)2.44431751
83indole-containing compound catabolic process (GO:0042436)2.44327066
84indolalkylamine catabolic process (GO:0046218)2.44327066
85tryptophan catabolic process (GO:0006569)2.44327066
86cellular ketone body metabolic process (GO:0046950)2.43500608
87positive regulation of cAMP-mediated signaling (GO:0043950)2.42086091
88eye photoreceptor cell development (GO:0042462)2.41393723
89regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41324723
90regulation of collateral sprouting (GO:0048670)2.40348762
91regulation of memory T cell differentiation (GO:0043380)2.40242913
92regulation of telomere maintenance (GO:0032204)2.37299232
93detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.37294069
94leukocyte aggregation (GO:0070486)2.34812773
95ketone body metabolic process (GO:1902224)2.33555737
96positive regulation of granulocyte differentiation (GO:0030854)2.32664976
97positive regulation of response to oxidative stress (GO:1902884)2.30970327
98positive regulation of cellular response to oxidative stress (GO:1900409)2.30970327
99cilium movement (GO:0003341)2.30311868
100water-soluble vitamin biosynthetic process (GO:0042364)2.30269321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.26915154
2ZNF274_21170338_ChIP-Seq_K562_Hela3.26005975
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.85672208
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74734171
5GBX2_23144817_ChIP-Seq_PC3_Human2.58558867
6FUS_26573619_Chip-Seq_HEK293_Human2.47386793
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.39026215
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37910858
9EWS_26573619_Chip-Seq_HEK293_Human2.33382049
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.29154041
11ER_23166858_ChIP-Seq_MCF-7_Human2.20472031
12TAF15_26573619_Chip-Seq_HEK293_Human2.17867319
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.15688650
14IGF1R_20145208_ChIP-Seq_DFB_Human2.14321199
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08740118
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.07539040
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98284695
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95285222
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93510130
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88959758
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87686821
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.82423344
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81562352
24P300_19829295_ChIP-Seq_ESCs_Human1.80156112
25TP53_22573176_ChIP-Seq_HFKS_Human1.77677971
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75014826
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68980448
28ELK1_19687146_ChIP-ChIP_HELA_Human1.66702948
29BCAT_22108803_ChIP-Seq_LS180_Human1.62090364
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61681107
31VDR_23849224_ChIP-Seq_CD4+_Human1.59772210
32EZH2_22144423_ChIP-Seq_EOC_Human1.56172315
33GATA3_26560356_Chip-Seq_TH2_Human1.54532075
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50248332
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48212454
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46845353
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46321730
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45656358
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44879361
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.43706398
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43467038
42CBP_20019798_ChIP-Seq_JUKART_Human1.43467038
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42623652
44CDX2_22108803_ChIP-Seq_LS180_Human1.40393376
45AR_25329375_ChIP-Seq_VCAP_Human1.40222821
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40080251
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38047618
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37983071
49TCF4_23295773_ChIP-Seq_U87_Human1.37686899
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37414904
51STAT3_23295773_ChIP-Seq_U87_Human1.36256886
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.35869464
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35869464
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.35250976
55RUNX_20019798_ChIP-Seq_JUKART_Human1.34338313
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.31425185
57TCF4_22108803_ChIP-Seq_LS180_Human1.27764579
58SOX2_19829295_ChIP-Seq_ESCs_Human1.27740581
59NANOG_19829295_ChIP-Seq_ESCs_Human1.27740581
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26956612
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.26890651
62MYC_18940864_ChIP-ChIP_HL60_Human1.26839317
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26250399
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25467701
65SMAD4_21799915_ChIP-Seq_A2780_Human1.23566017
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23516143
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23067991
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23067991
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.21770585
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21380498
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19832537
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.19610782
73AR_20517297_ChIP-Seq_VCAP_Human1.18337829
74NCOR_22424771_ChIP-Seq_293T_Human1.17888984
75RUNX2_22187159_ChIP-Seq_PCA_Human1.16608757
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.16048304
77SMRT_27268052_Chip-Seq_Bcells_Human1.15750730
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.15160735
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.14834453
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.14672549
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14353927
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14240965
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.14163823
84HOXB7_26014856_ChIP-Seq_BT474_Human1.13875928
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.13517463
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13387541
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12772728
88GATA3_26560356_Chip-Seq_TH1_Human1.10933061
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09741036
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09571790
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09526158
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09497239
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05779218
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04342067
95TP53_16413492_ChIP-PET_HCT116_Human1.02441606
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02224757
97P53_22387025_ChIP-Seq_ESCs_Mouse1.02100928
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01796888
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.01654608
100RNF2_27304074_Chip-Seq_NSC_Mouse1.00430065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.49677330
2MP0000569_abnormal_digit_pigmentation2.97898479
3MP0003787_abnormal_imprinting2.63704772
4MP0003011_delayed_dark_adaptation2.52100508
5MP0004147_increased_porphyrin_level2.47491224
6MP0003880_abnormal_central_pattern2.43962921
7MP0003136_yellow_coat_color2.33954303
8MP0005551_abnormal_eye_electrophysiolog2.31040340
9MP0004885_abnormal_endolymph2.30152812
10MP0006292_abnormal_olfactory_placode2.21932141
11MP0005671_abnormal_response_to1.95450994
12MP0005310_abnormal_salivary_gland1.94562909
13MP0002277_abnormal_respiratory_mucosa1.89767253
14MP0000372_irregular_coat_pigmentation1.88696628
15MP0005174_abnormal_tail_pigmentation1.88592925
16MP0000427_abnormal_hair_cycle1.87085909
17MP0003195_calcinosis1.85657308
18MP0001984_abnormal_olfaction1.83856280
19MP0003724_increased_susceptibility_to1.81499851
20MP0008789_abnormal_olfactory_epithelium1.78519427
21MP0002837_dystrophic_cardiac_calcinosis1.77850633
22MP0001986_abnormal_taste_sensitivity1.73544012
23MP0004142_abnormal_muscle_tone1.71366860
24MP0002210_abnormal_sex_determination1.68890606
25MP0002876_abnormal_thyroid_physiology1.68653330
26MP0003646_muscle_fatigue1.65920648
27MP0001485_abnormal_pinna_reflex1.62730177
28MP0001800_abnormal_humoral_immune1.56817703
29MP0001929_abnormal_gametogenesis1.54521672
30MP0008058_abnormal_DNA_repair1.52483692
31MP0008872_abnormal_physiological_respon1.47549300
32MP0001968_abnormal_touch/_nociception1.44707412
33MP0005646_abnormal_pituitary_gland1.43419194
34MP0002638_abnormal_pupillary_reflex1.41052553
35MP0004742_abnormal_vestibular_system1.39928689
36MP0002102_abnormal_ear_morphology1.39790044
37MP0002653_abnormal_ependyma_morphology1.36945462
38MP0001502_abnormal_circadian_rhythm1.35404389
39MP0003698_abnormal_male_reproductive1.32762669
40MP0010030_abnormal_orbit_morphology1.32600834
41MP0002938_white_spotting1.28609514
42MP0001835_abnormal_antigen_presentation1.28117396
43MP0001324_abnormal_eye_pigmentation1.26268788
44MP0005389_reproductive_system_phenotype1.22756831
45MP0000015_abnormal_ear_pigmentation1.22641492
46MP0001145_abnormal_male_reproductive1.20067274
47MP0002095_abnormal_skin_pigmentation1.19806649
48MP0000653_abnormal_sex_gland1.18981903
49MP0005410_abnormal_fertilization1.17892255
50MP0002693_abnormal_pancreas_physiology1.17182800
51MP0004381_abnormal_hair_follicle1.14795927
52MP0001919_abnormal_reproductive_system1.13224993
53MP0009745_abnormal_behavioral_response1.12789157
54MP0002736_abnormal_nociception_after1.12613659
55MP0009785_altered_susceptibility_to1.12224757
56MP0008875_abnormal_xenobiotic_pharmacok1.11869106
57MP0000631_abnormal_neuroendocrine_gland1.08807969
58MP0002723_abnormal_immune_serum1.06842390
59MP0005253_abnormal_eye_physiology1.05985498
60MP0005075_abnormal_melanosome_morpholog1.05660336
61MP0006082_CNS_inflammation1.04822623
62MP0001873_stomach_inflammation1.04126029
63MP0001119_abnormal_female_reproductive1.02205046
64MP0002148_abnormal_hypersensitivity_rea1.00808896
65MP0009764_decreased_sensitivity_to1.00744424
66MP0002254_reproductive_system_inflammat1.00316001
67MP0000230_abnormal_systemic_arterial0.98019014
68MP0003763_abnormal_thymus_physiology0.95273782
69MP0006072_abnormal_retinal_apoptosis0.94639321
70MP0005394_taste/olfaction_phenotype0.94280315
71MP0005499_abnormal_olfactory_system0.94280315
72MP0001790_abnormal_immune_system0.94176482
73MP0005387_immune_system_phenotype0.94176482
74MP0002160_abnormal_reproductive_system0.93898245
75MP0000685_abnormal_immune_system0.92788480
76MP0000383_abnormal_hair_follicle0.92679222
77MP0001501_abnormal_sleep_pattern0.91869930
78MP0005084_abnormal_gallbladder_morpholo0.89305683
79MP0005000_abnormal_immune_tolerance0.87437979
80MP0001970_abnormal_pain_threshold0.86627641
81MP0002452_abnormal_antigen_presenting0.86120142
82MP0003786_premature_aging0.84670091
83MP0002067_abnormal_sensory_capabilities0.84645486
84MP0005195_abnormal_posterior_eye0.84480974
85MP0001188_hyperpigmentation0.84285956
86MP0002420_abnormal_adaptive_immunity0.83676390
87MP0000566_synostosis0.83068804
88MP0002272_abnormal_nervous_system0.82773671
89MP0005448_abnormal_energy_balance0.82327843
90MP0001819_abnormal_immune_cell0.80387238
91MP0000026_abnormal_inner_ear0.77169009
92MP0004484_altered_response_of0.75482298
93MP0000689_abnormal_spleen_morphology0.73743553
94MP0002138_abnormal_hepatobiliary_system0.73479621
95MP0004215_abnormal_myocardial_fiber0.73387469
96MP0004133_heterotaxia0.71289704
97MP0002163_abnormal_gland_morphology0.70256688
98MP0008995_early_reproductive_senescence0.70058462
99MP0005386_behavior/neurological_phenoty0.68617009
100MP0004924_abnormal_behavior0.68617009

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.71842345
2Abnormality of midbrain morphology (HP:0002418)4.40926014
3Molar tooth sign on MRI (HP:0002419)4.40926014
4Pancreatic cysts (HP:0001737)4.22259031
5Type II lissencephaly (HP:0007260)4.18400080
6Pancreatic fibrosis (HP:0100732)3.91924366
7Stomatitis (HP:0010280)3.85672158
8Abnormality of the renal cortex (HP:0011035)3.62882576
9True hermaphroditism (HP:0010459)3.56763945
10Cerebellar dysplasia (HP:0007033)3.26794933
11Nephronophthisis (HP:0000090)3.26224719
12Abnormality of alanine metabolism (HP:0010916)3.15300082
13Hyperalaninemia (HP:0003348)3.15300082
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15300082
15Medial flaring of the eyebrow (HP:0010747)2.99794088
16Tubular atrophy (HP:0000092)2.89678463
17Abnormality of the renal medulla (HP:0100957)2.88750335
18Azoospermia (HP:0000027)2.86595836
19Aplasia/Hypoplasia of the tibia (HP:0005772)2.71258190
20Chronic hepatic failure (HP:0100626)2.57968771
21Oligodactyly (hands) (HP:0001180)2.55503109
22Attenuation of retinal blood vessels (HP:0007843)2.51142830
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.47259894
24Absent/shortened dynein arms (HP:0200106)2.47259894
25Short tibia (HP:0005736)2.42811137
26Renal cortical cysts (HP:0000803)2.42019807
27Abnormality of DNA repair (HP:0003254)2.41614841
28Decreased central vision (HP:0007663)2.38440809
29Retinal dysplasia (HP:0007973)2.35287809
30Congenital primary aphakia (HP:0007707)2.30395892
31Abnormal respiratory epithelium morphology (HP:0012253)2.29488450
32Abnormal respiratory motile cilium morphology (HP:0005938)2.29488450
33Abnormal ciliary motility (HP:0012262)2.28309087
34Cystic liver disease (HP:0006706)2.28232824
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26079433
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.26079433
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.25678137
38Gait imbalance (HP:0002141)2.25349710
39Abnormal rod and cone electroretinograms (HP:0008323)2.24635255
40Abnormal spermatogenesis (HP:0008669)2.24418331
41Meckel diverticulum (HP:0002245)2.17958802
42Nephrogenic diabetes insipidus (HP:0009806)2.13394904
43Hyperventilation (HP:0002883)2.12185688
44Large for gestational age (HP:0001520)2.11187770
45Poor coordination (HP:0002370)2.11051614
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.10634543
47Abnormality of the ileum (HP:0001549)2.09435374
48Abnormality of chromosome stability (HP:0003220)2.08284911
49Male pseudohermaphroditism (HP:0000037)2.05949202
50Postaxial foot polydactyly (HP:0001830)2.05680621
51Abnormality of T cell number (HP:0011839)2.02803132
52Gaze-evoked nystagmus (HP:0000640)2.02160111
53Methylmalonic acidemia (HP:0002912)2.02028505
54Polydipsia (HP:0001959)2.01842957
55Abnormal drinking behavior (HP:0030082)2.01842957
56Optic neuritis (HP:0100653)2.01478591
57Retrobulbar optic neuritis (HP:0100654)2.01478591
58Chronic sinusitis (HP:0011109)2.01204950
59Optic nerve hypoplasia (HP:0000609)2.00751921
60T lymphocytopenia (HP:0005403)2.00005054
613-Methylglutaconic aciduria (HP:0003535)1.97224899
62Congenital hepatic fibrosis (HP:0002612)1.95554692
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92883040
64Hypoplasia of the fovea (HP:0007750)1.91799602
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.91799602
66Septo-optic dysplasia (HP:0100842)1.89528702
67Congenital, generalized hypertrichosis (HP:0004540)1.87596636
68Genital tract atresia (HP:0001827)1.86518728
69Widely spaced teeth (HP:0000687)1.86371104
70Abolished electroretinogram (ERG) (HP:0000550)1.83548759
71IgG deficiency (HP:0004315)1.82624071
72Clubbing of toes (HP:0100760)1.82427376
73Oligodactyly (HP:0012165)1.82199495
74Abnormal respiratory motile cilium physiology (HP:0012261)1.81889686
75Postaxial hand polydactyly (HP:0001162)1.80509139
76Furrowed tongue (HP:0000221)1.80015328
77Abnormality of vitamin B metabolism (HP:0004340)1.79138551
78Gonadotropin excess (HP:0000837)1.75908498
79Hypoplastic iliac wings (HP:0002866)1.74356604
80Fair hair (HP:0002286)1.72743040
81Colon cancer (HP:0003003)1.69767462
82Ectopic kidney (HP:0000086)1.69617071
83Vaginal atresia (HP:0000148)1.69189848
84Increased CSF lactate (HP:0002490)1.69164370
85Progressive inability to walk (HP:0002505)1.68510576
86Astigmatism (HP:0000483)1.67756684
87Abnormality of the preputium (HP:0100587)1.65471888
88Acute necrotizing encephalopathy (HP:0006965)1.65396611
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64577652
90Absent thumb (HP:0009777)1.64024414
91Scotoma (HP:0000575)1.63092226
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61030797
93Rib fusion (HP:0000902)1.59395007
94Sclerocornea (HP:0000647)1.59038122
95Abnormality of the fovea (HP:0000493)1.58991275
96Mitochondrial inheritance (HP:0001427)1.58348472
97Lissencephaly (HP:0001339)1.58293520
98Decreased circulating renin level (HP:0003351)1.58281189
99Lipid accumulation in hepatocytes (HP:0006561)1.57890279
100Broad-based gait (HP:0002136)1.57496835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.83161212
2TAOK33.68029983
3MAP4K23.44318421
4ADRBK22.37628935
5TXK2.32211693
6WNK32.26183709
7BRSK22.21198509
8AKT32.18906857
9ACVR1B2.14804780
10ZAK2.13930688
11IRAK12.13277654
12PNCK2.01862684
13MST42.01765162
14EIF2AK31.92809336
15NUAK11.92750306
16BMPR1B1.86059037
17WEE11.76046167
18PINK11.67954905
19WNK41.67525212
20TNK21.63997817
21TEC1.57863025
22GRK11.56141068
23MAP3K131.51813340
24CAMKK21.45645730
25MAPK131.39301890
26MAP3K91.39202354
27TRIM281.38442549
28PLK21.28592182
29STK391.27063235
30PAK31.19777026
31MAP4K11.17908220
32TAF11.10384432
33PRKCE1.09316003
34PTK2B1.04886150
35TLK11.04115413
36ITK1.00678118
37ADRBK10.93425170
38NLK0.93295369
39DYRK30.93038304
40KIT0.92207184
41IKBKB0.92016874
42MARK30.90803414
43STK38L0.89665489
44OXSR10.89249460
45STK30.88823531
46EPHA40.87882620
47INSRR0.83187646
48CSF1R0.82681684
49VRK10.80933190
50BRD40.80838235
51PRKCQ0.80076485
52GRK50.78554633
53DAPK20.74224754
54PIK3CG0.70560214
55TGFBR10.70225685
56TSSK60.69432337
57IRAK40.66576201
58KSR10.66468098
59PDK20.65571239
60PASK0.65220392
61TNIK0.65031599
62BTK0.64455724
63SYK0.62797744
64BRAF0.62030607
65DYRK20.59472677
66GRK70.58819433
67SGK10.56235276
68LYN0.55813072
69MKNK20.55466982
70MAP2K60.54602360
71EIF2AK10.54222958
72RPS6KA50.53116859
73CSNK1G20.51945031
74PIK3CA0.51839301
75STK110.50636243
76MOS0.49630777
77MELK0.49051092
78CDK30.48859007
79SGK20.48410170
80PLK30.47542030
81MAP3K120.46625746
82CAMK10.45504021
83WNK10.44475067
84DYRK1A0.43345714
85IKBKE0.39723902
86FLT30.39702259
87PIM10.39274883
88EIF2AK20.39263581
89CASK0.36403914
90CHUK0.36101617
91MAP3K40.35014433
92LCK0.34885985
93CSNK1G10.34671071
94TRPM70.34090525
95PRKCG0.33859961
96IRAK20.31296429
97PRKCI0.30212675
98PRKG10.30149491
99ZAP700.28430782
100FES0.28422999

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.30846706
2Basal transcription factors_Homo sapiens_hsa030222.94886000
3Regulation of autophagy_Homo sapiens_hsa041402.65580563
4Homologous recombination_Homo sapiens_hsa034402.63783973
5Nitrogen metabolism_Homo sapiens_hsa009102.41892055
6Phototransduction_Homo sapiens_hsa047442.25303656
7Primary immunodeficiency_Homo sapiens_hsa053402.24832632
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04066801
9Linoleic acid metabolism_Homo sapiens_hsa005911.99024804
10Fanconi anemia pathway_Homo sapiens_hsa034601.97654444
11Protein export_Homo sapiens_hsa030601.91437053
12Oxidative phosphorylation_Homo sapiens_hsa001901.84291595
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78558934
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74386497
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67393943
16Circadian rhythm_Homo sapiens_hsa047101.57399301
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52271811
18Parkinsons disease_Homo sapiens_hsa050121.48866891
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46100824
20Tryptophan metabolism_Homo sapiens_hsa003801.40917742
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36338451
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35809241
23RNA degradation_Homo sapiens_hsa030181.35224402
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.35216590
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34230954
26Ether lipid metabolism_Homo sapiens_hsa005651.22882561
27Sulfur metabolism_Homo sapiens_hsa009201.21214450
28Caffeine metabolism_Homo sapiens_hsa002321.19654218
29Chemical carcinogenesis_Homo sapiens_hsa052041.18800282
30Hematopoietic cell lineage_Homo sapiens_hsa046401.18155327
31RNA polymerase_Homo sapiens_hsa030201.15385673
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15063867
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14958697
34Taste transduction_Homo sapiens_hsa047421.13151368
35Propanoate metabolism_Homo sapiens_hsa006401.12558298
36T cell receptor signaling pathway_Homo sapiens_hsa046601.11469264
37Nucleotide excision repair_Homo sapiens_hsa034201.11149260
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.10342149
39Butanoate metabolism_Homo sapiens_hsa006501.09797538
40Huntingtons disease_Homo sapiens_hsa050161.06978259
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06550698
42Olfactory transduction_Homo sapiens_hsa047401.06002465
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04962609
44Peroxisome_Homo sapiens_hsa041461.04503016
45Dorso-ventral axis formation_Homo sapiens_hsa043201.04377454
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03898897
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.00042622
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97764049
49One carbon pool by folate_Homo sapiens_hsa006700.96348401
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.94602782
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94357301
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93384794
53Serotonergic synapse_Homo sapiens_hsa047260.91385759
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90153591
55Arachidonic acid metabolism_Homo sapiens_hsa005900.88997961
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88519462
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83755652
58Allograft rejection_Homo sapiens_hsa053300.83119188
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82487140
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81829392
61Nicotine addiction_Homo sapiens_hsa050330.81104491
62Alzheimers disease_Homo sapiens_hsa050100.78380068
63Type I diabetes mellitus_Homo sapiens_hsa049400.78291672
64Morphine addiction_Homo sapiens_hsa050320.75847251
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75642210
66Non-homologous end-joining_Homo sapiens_hsa034500.75356623
67Measles_Homo sapiens_hsa051620.74273566
68Autoimmune thyroid disease_Homo sapiens_hsa053200.74087897
69Mineral absorption_Homo sapiens_hsa049780.73660383
70Proteasome_Homo sapiens_hsa030500.72457121
71Cardiac muscle contraction_Homo sapiens_hsa042600.72351597
72Retinol metabolism_Homo sapiens_hsa008300.69664221
73Insulin secretion_Homo sapiens_hsa049110.68100615
74Graft-versus-host disease_Homo sapiens_hsa053320.67986310
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66871089
76Ovarian steroidogenesis_Homo sapiens_hsa049130.64575709
77Antigen processing and presentation_Homo sapiens_hsa046120.61530922
78ABC transporters_Homo sapiens_hsa020100.58278624
79RNA transport_Homo sapiens_hsa030130.56176652
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.55840028
81Mismatch repair_Homo sapiens_hsa034300.54091726
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51398316
83p53 signaling pathway_Homo sapiens_hsa041150.50723047
84Asthma_Homo sapiens_hsa053100.50269221
85Amphetamine addiction_Homo sapiens_hsa050310.50201497
86Calcium signaling pathway_Homo sapiens_hsa040200.48752647
87Cocaine addiction_Homo sapiens_hsa050300.46749134
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46428018
89Purine metabolism_Homo sapiens_hsa002300.46028938
90Glutamatergic synapse_Homo sapiens_hsa047240.45819534
91Legionellosis_Homo sapiens_hsa051340.45434968
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.42618622
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42108792
94Hedgehog signaling pathway_Homo sapiens_hsa043400.41456077
95FoxO signaling pathway_Homo sapiens_hsa040680.40307930
96Collecting duct acid secretion_Homo sapiens_hsa049660.38314570
97Circadian entrainment_Homo sapiens_hsa047130.37816977
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.37013091
99Ribosome_Homo sapiens_hsa030100.35866611
100cAMP signaling pathway_Homo sapiens_hsa040240.34469186

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