ACR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* binding of sperm to zona pellucida (GO:0007339)9.81654927
2* cell-cell recognition (GO:0009988)9.76290097
3spermatid development (GO:0007286)9.52558142
4motile cilium assembly (GO:0044458)9.44433091
5piRNA metabolic process (GO:0034587)9.17613464
6regulation of cilium movement (GO:0003352)8.92629018
7cilium movement (GO:0003341)8.68163426
8* reproduction (GO:0000003)8.40725046
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.38818567
10male meiosis (GO:0007140)8.21758298
11response to pheromone (GO:0019236)8.17118159
12synaptonemal complex organization (GO:0070193)7.87013230
13synaptonemal complex assembly (GO:0007130)7.55370955
14sperm capacitation (GO:0048240)7.36495986
15* single fertilization (GO:0007338)7.05775549
16negative regulation of inclusion body assembly (GO:0090084)6.70910483
17pattern specification involved in kidney development (GO:0061004)6.48304466
18spermatogenesis (GO:0007283)6.34263986
19male gamete generation (GO:0048232)6.31924850
20* fertilization (GO:0009566)6.11346271
21organic cation transport (GO:0015695)5.94995815
22microtubule depolymerization (GO:0007019)5.93207973
23histone H3-K9 demethylation (GO:0033169)5.88541730
24ventricular system development (GO:0021591)5.87868021
25gamete generation (GO:0007276)5.80461263
26DNA methylation involved in gamete generation (GO:0043046)5.72878007
27male meiosis I (GO:0007141)5.67563512
28regulation of inclusion body assembly (GO:0090083)5.47236489
29protein targeting to Golgi (GO:0000042)5.44520241
30germ cell development (GO:0007281)5.44220227
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.41960496
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.39489558
33regulation of phosphoprotein phosphatase activity (GO:0043666)5.36516059
34regulation of microtubule-based movement (GO:0060632)5.30757238
35establishment of protein localization to Golgi (GO:0072600)5.18703279
36chromosome organization involved in meiosis (GO:0070192)5.17656993
37phosphatidylethanolamine metabolic process (GO:0046337)5.10348267
38retrograde transport, vesicle recycling within Golgi (GO:0000301)5.07149567
39microtubule severing (GO:0051013)5.06407871
40seminiferous tubule development (GO:0072520)4.91742284
41* cell recognition (GO:0008037)4.88180332
42* calcium ion-dependent exocytosis (GO:0017156)4.78229075
43meiotic nuclear division (GO:0007126)4.73640055
44cellular ketone body metabolic process (GO:0046950)4.68002739
45positive regulation of catecholamine secretion (GO:0033605)4.60795669
46left/right pattern formation (GO:0060972)4.55954028
47* multicellular organismal reproductive process (GO:0048609)4.52887687
48meiosis I (GO:0007127)4.51068272
49coenzyme catabolic process (GO:0009109)4.51032677
50protein localization to cilium (GO:0061512)4.38357222
51rRNA methylation (GO:0031167)4.27062784
52polyamine biosynthetic process (GO:0006596)4.23435159
53spermatid nucleus differentiation (GO:0007289)4.21864585
54meiotic cell cycle (GO:0051321)4.10710844
55ketone body metabolic process (GO:1902224)4.06525716
56protein polyglutamylation (GO:0018095)4.00716225
57chromosome condensation (GO:0030261)3.90662401
58protein localization to Golgi apparatus (GO:0034067)3.89297713
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.87503771
60glycerol ether metabolic process (GO:0006662)3.83591401
61DNA packaging (GO:0006323)3.77728330
62multicellular organismal development (GO:0007275)3.72721730
63genitalia morphogenesis (GO:0035112)3.71204723
64chaperone-mediated protein complex assembly (GO:0051131)3.68331561
65response to acidic pH (GO:0010447)3.66762337
66regulation of Rab GTPase activity (GO:0032313)3.63307696
67positive regulation of Rab GTPase activity (GO:0032851)3.63307696
68protein-DNA complex disassembly (GO:0032986)3.54459747
69nucleosome disassembly (GO:0006337)3.54459747
70ether metabolic process (GO:0018904)3.53561692
71intraciliary transport (GO:0042073)3.52570340
72regulation of transcription involved in cell fate commitment (GO:0060850)3.48498264
73monoubiquitinated protein deubiquitination (GO:0035520)3.48159341
74axoneme assembly (GO:0035082)3.46787959
75gene silencing by RNA (GO:0031047)3.34899864
76multicellular organismal movement (GO:0050879)3.33012124
77musculoskeletal movement (GO:0050881)3.33012124
78RNA destabilization (GO:0050779)3.32799041
79microtubule-based movement (GO:0007018)3.31576815
80rRNA modification (GO:0000154)3.30580041
81amino-acid betaine transport (GO:0015838)3.23927078
82carnitine transport (GO:0015879)3.23927078
83lactate metabolic process (GO:0006089)3.23779886
84cilium organization (GO:0044782)3.20684752
85negative regulation of organelle assembly (GO:1902116)3.18802938
86nucleoside diphosphate phosphorylation (GO:0006165)3.17498977
87carnitine transmembrane transport (GO:1902603)3.17103764
88mitotic sister chromatid cohesion (GO:0007064)3.13476976
89protein refolding (GO:0042026)3.08539964
90cilium assembly (GO:0042384)3.08424977
91cellular response to pH (GO:0071467)3.08369474
92regulation of spindle checkpoint (GO:0090231)3.05224361
93cellular biogenic amine biosynthetic process (GO:0042401)3.04576590
94cilium morphogenesis (GO:0060271)3.01710078
95meiotic cell cycle process (GO:1903046)3.01697627
96synapsis (GO:0007129)3.01429900
97microtubule polymerization or depolymerization (GO:0031109)3.00201047
98cellular component assembly involved in morphogenesis (GO:0010927)2.99070870
99homeostasis of number of cells within a tissue (GO:0048873)2.96456465
100cranial nerve morphogenesis (GO:0021602)2.95673366
101amine biosynthetic process (GO:0009309)2.94012612
102receptor recycling (GO:0001881)2.93472780
103polyol catabolic process (GO:0046174)2.90530512
104single strand break repair (GO:0000012)2.89998111
105alditol metabolic process (GO:0019400)2.86899101
106positive regulation of endothelial cell differentiation (GO:0045603)2.83320324
107protein K11-linked deubiquitination (GO:0035871)2.83067074
108glycolytic process (GO:0006096)2.80359759
109nucleus organization (GO:0006997)2.79219801
110chromatin silencing (GO:0006342)2.77302131
111peptidyl-glutamic acid modification (GO:0018200)2.76799021
112regulation of meiosis I (GO:0060631)2.75603963
113sexual reproduction (GO:0019953)2.74968337
114regulation of centriole replication (GO:0046599)2.74336284
115regulation of ARF GTPase activity (GO:0032312)2.73654135
116GTP biosynthetic process (GO:0006183)2.73309625
117regulation of dopamine secretion (GO:0014059)2.72535034
118detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.72395952
119RNA localization (GO:0006403)2.71931933
120mitochondrion degradation (GO:0000422)2.69749468
121positive regulation of cGMP biosynthetic process (GO:0030828)2.68696436
122regulation of cilium assembly (GO:1902017)2.65806338
123positive regulation of glycolytic process (GO:0045821)2.65036966
124polyamine metabolic process (GO:0006595)2.64474697
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.63522101
126cofactor catabolic process (GO:0051187)2.63495895
127sequestering of actin monomers (GO:0042989)2.62705048
128negative regulation of Rho protein signal transduction (GO:0035024)2.60824199
129regulation of chromatin binding (GO:0035561)2.59552253
130segment specification (GO:0007379)2.59034374
131activation of protein kinase B activity (GO:0032148)2.58435580
132centriole assembly (GO:0098534)2.58131642
133regulation of synaptic transmission, dopaminergic (GO:0032225)2.57631394
134centriole replication (GO:0007099)2.57447959
135cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.57056672
136gene silencing (GO:0016458)2.56970744
137calcium ion import (GO:0070509)2.51409456
138sperm motility (GO:0030317)13.2157339
139fusion of sperm to egg plasma membrane (GO:0007342)13.0728896
140cilium or flagellum-dependent cell motility (GO:0001539)12.7617557
141acrosome assembly (GO:0001675)11.3125198
142* sperm-egg recognition (GO:0035036)10.9698363
143cell wall macromolecule catabolic process (GO:0016998)10.8627750
144cell wall macromolecule metabolic process (GO:0044036)10.8627750
145axonemal dynein complex assembly (GO:0070286)10.6603620
146* acrosome reaction (GO:0007340)10.2778529
147epithelial cilium movement (GO:0003351)10.1638812
148* multicellular organism reproduction (GO:0032504)10.1045205
149plasma membrane fusion (GO:0045026)10.0238752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.52851615
2EZH2_22144423_ChIP-Seq_EOC_Human5.94547289
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66556141
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.37743550
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24363882
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19066495
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04334025
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71152474
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.56661364
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39784355
11VDR_22108803_ChIP-Seq_LS180_Human2.21371162
12ZNF274_21170338_ChIP-Seq_K562_Hela2.18301711
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12921777
14SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.05342294
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03011288
16* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01871130
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.01250659
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95263531
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.92035584
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88892124
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85682870
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82000022
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77723205
24RAC3_21632823_ChIP-Seq_H3396_Human1.76408827
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73447671
26ERA_21632823_ChIP-Seq_H3396_Human1.72009893
27NANOG_20526341_ChIP-Seq_ESCs_Human1.69994469
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69358263
29CTCF_27219007_Chip-Seq_Bcells_Human1.68413818
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63517049
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62748390
32GBX2_23144817_ChIP-Seq_PC3_Human1.61838065
33REST_21632747_ChIP-Seq_MESCs_Mouse1.60941916
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59680717
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58650502
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.58480330
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.58280821
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.57442207
39STAT1_17558387_ChIP-Seq_HELA_Human1.57105429
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56480266
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.53891157
42DROSHA_22980978_ChIP-Seq_HELA_Human1.51286496
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49900571
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46084668
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.45554041
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44191111
47AR_25329375_ChIP-Seq_VCAP_Human1.43299141
48KDM2B_26808549_Chip-Seq_REH_Human1.42577766
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42574731
50P300_19829295_ChIP-Seq_ESCs_Human1.42409270
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42107207
52CBP_20019798_ChIP-Seq_JUKART_Human1.42107207
53SMC4_20622854_ChIP-Seq_HELA_Human1.40579222
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40346431
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.39756297
56OCT4_20526341_ChIP-Seq_ESCs_Human1.37176058
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35607125
58CTCF_20526341_ChIP-Seq_ESCs_Human1.34099045
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.33163439
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32691673
61* EZH2_27294783_Chip-Seq_ESCs_Mouse1.32513638
62MYC_19829295_ChIP-Seq_ESCs_Human1.31856392
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31624350
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31300929
65TAF15_26573619_Chip-Seq_HEK293_Human1.28948031
66AR_21572438_ChIP-Seq_LNCaP_Human1.28344722
67BCL6_27268052_Chip-Seq_Bcells_Human1.28307660
68TP53_18474530_ChIP-ChIP_U2OS_Human1.27940465
69FUS_26573619_Chip-Seq_HEK293_Human1.27247287
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.26138903
71GATA3_21867929_ChIP-Seq_CD8_Mouse1.25956998
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25079202
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25079202
74TP63_22573176_ChIP-Seq_HFKS_Human1.24502505
75SMAD4_21799915_ChIP-Seq_A2780_Human1.24118553
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23592506
77RUNX2_22187159_ChIP-Seq_PCA_Human1.23347492
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.23142472
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22895959
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22481893
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21883271
82RNF2_27304074_Chip-Seq_NSC_Mouse1.21706971
83* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21558145
84OCT1_27270436_Chip-Seq_PROSTATE_Human1.21503793
85PHF8_20622854_ChIP-Seq_HELA_Human1.19473137
86BCOR_27268052_Chip-Seq_Bcells_Human1.19459654
87P300_27268052_Chip-Seq_Bcells_Human1.19202254
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18410847
89TAF2_19829295_ChIP-Seq_ESCs_Human1.18345362
90E2F1_20622854_ChIP-Seq_HELA_Human1.18128244
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.17887479
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16803785
93KLF4_19829295_ChIP-Seq_ESCs_Human1.16557304
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15930478
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15634571
96* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15351805
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15140713
98FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14886023
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14811050
100P68_20966046_ChIP-Seq_HELA_Human1.14395865
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13605594
102P53_21459846_ChIP-Seq_SAOS-2_Human1.13436702
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.12137938
104AHR_22903824_ChIP-Seq_MCF-7_Human1.10628498
105GF1_26923725_Chip-Seq_HPCs_Mouse1.10197352
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.09558942
107GATA3_21867929_ChIP-Seq_TH1_Mouse1.08621635
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.08595685
109LXR_22292898_ChIP-Seq_THP-1_Human1.08452561
110* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07482108
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06855006
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06366512
113STAT3_23295773_ChIP-Seq_U87_Human1.06182903
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06036400
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.05963272
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.05783531
117OCT4_19829295_ChIP-Seq_ESCs_Human1.05605322
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05486689
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05352232
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05069526
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04585005
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.04355625
123CJUN_26792858_Chip-Seq_BT549_Human1.04111391
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04026237
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03954571
126TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03049699
127RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02898243
128TBL1_22424771_ChIP-Seq_293T_Human1.02710590
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.02418223
130RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02369444
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.02208546
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02102393
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.99780549
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99266201
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99061479
136P53_22387025_ChIP-Seq_ESCs_Mouse0.98611572
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98506582
138SPI1_20517297_ChIP-Seq_HL60_Human0.97911810
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.97449252
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97016169
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96596049
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96084013
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95283962
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.95039583
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94985529
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94332429
147SOX9_26525672_Chip-Seq_HEART_Mouse0.92286435
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91984377
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.91496083
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.90759150
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.90009901
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.89625275
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89452588
154MYC_27129775_Chip-Seq_CORNEA_Mouse0.88842082
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88758768
156P300_18555785_Chip-Seq_ESCs_Mouse0.88532948
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.87842714
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86588300
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85948331
160STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85597311
161GF1B_26923725_Chip-Seq_HPCs_Mouse0.84715342
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84546675
163TCF4_23295773_ChIP-Seq_U87_Human0.84468205
164ERG_20517297_ChIP-Seq_VCAP_Human0.84177360
165SMAD3_21741376_ChIP-Seq_ESCs_Human0.84018589
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83644475
167SOX11_22085726_ChIP-Seq_ESNs_Mouse0.82955837
168NFYB_21822215_ChIP-Seq_K562_Human0.82881179
169ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82569678
170ER_23166858_ChIP-Seq_MCF-7_Human0.82276992
171SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82250284
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.82107173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.91627205
2* MP0001929_abnormal_gametogenesis5.32142870
3MP0008877_abnormal_DNA_methylation4.93748350
4MP0002210_abnormal_sex_determination3.56673512
5* MP0002161_abnormal_fertility/fecundity3.19857029
6MP0001145_abnormal_male_reproductive2.96794788
7MP0002653_abnormal_ependyma_morphology2.89647157
8MP0000653_abnormal_sex_gland2.57367035
9MP0008004_abnormal_stomach_pH2.51654585
10MP0010368_abnormal_lymphatic_system2.42251020
11MP0004510_myositis2.30722957
12MP0005360_urolithiasis2.25810668
13MP0005670_abnormal_white_adipose2.18293676
14MP0002132_abnormal_respiratory_system2.10297753
15MP0005623_abnormal_meninges_morphology2.08416171
16* MP0005410_abnormal_fertilization15.2780987
17MP0001879_abnormal_lymphatic_vessel1.96092437
18MP0000678_abnormal_parathyroid_gland1.95808519
19MP0004084_abnormal_cardiac_muscle1.91078855
20MP0002160_abnormal_reproductive_system1.80387924
21MP0003315_abnormal_perineum_morphology1.75870072
22MP0003136_yellow_coat_color1.74141130
23MP0005451_abnormal_body_composition1.65075731
24MP0003718_maternal_effect1.62754040
25MP0001984_abnormal_olfaction1.59250247
26MP0003646_muscle_fatigue1.58755884
27MP0002138_abnormal_hepatobiliary_system1.56916741
28MP0009046_muscle_twitch1.53220183
29MP0002127_abnormal_cardiovascular_syste1.49223853
30MP0000749_muscle_degeneration1.48402351
31MP0005248_abnormal_Harderian_gland1.37677630
32MP0002282_abnormal_trachea_morphology1.27552044
33MP0004233_abnormal_muscle_weight1.19220856
34MP0005167_abnormal_blood-brain_barrier1.18663343
35MP0009697_abnormal_copulation1.17327777
36MP0003806_abnormal_nucleotide_metabolis1.16864299
37MP0002249_abnormal_larynx_morphology1.16458792
38MP0002837_dystrophic_cardiac_calcinosis1.16374187
39MP0004484_altered_response_of1.14149991
40MP0001485_abnormal_pinna_reflex1.12872552
41MP0004085_abnormal_heartbeat1.12226186
42MP0008995_early_reproductive_senescence1.10706365
43MP0001502_abnormal_circadian_rhythm1.09508628
44MP0005377_hearing/vestibular/ear_phenot1.09472110
45MP0003878_abnormal_ear_physiology1.09472110
46MP0000230_abnormal_systemic_arterial1.07019194
47MP0005423_abnormal_somatic_nervous0.99629885
48MP0001348_abnormal_lacrimal_gland0.98083682
49MP0008058_abnormal_DNA_repair0.98062049
50MP0001765_abnormal_ion_homeostasis0.97936853
51MP0001905_abnormal_dopamine_level0.96833785
52MP0004859_abnormal_synaptic_plasticity0.96364147
53MP0003787_abnormal_imprinting0.96139374
54MP0001501_abnormal_sleep_pattern0.92883590
55MP0005389_reproductive_system_phenotype0.91279908
56MP0005647_abnormal_sex_gland0.90787200
57MP0008057_abnormal_DNA_replication0.88582155
58MP0001963_abnormal_hearing_physiology0.86855859
59MP0000026_abnormal_inner_ear0.86111807
60MP0001664_abnormal_digestion0.85949238
61MP0005395_other_phenotype0.84315198
62MP0002234_abnormal_pharynx_morphology0.81989224
63MP0005375_adipose_tissue_phenotype0.81422890
64MP0005620_abnormal_muscle_contractility0.80746880
65MP0004215_abnormal_myocardial_fiber0.79219226
66MP0009840_abnormal_foam_cell0.78114295
67MP0005595_abnormal_vascular_smooth0.77454325
68MP0008775_abnormal_heart_ventricle0.77044534
69MP0002108_abnormal_muscle_morphology0.71660555
70MP0003868_abnormal_feces_composition0.69278512
71MP0003632_abnormal_nervous_system0.67822022
72MP0005187_abnormal_penis_morphology0.67439999
73MP0005645_abnormal_hypothalamus_physiol0.65731984
74MP0003115_abnormal_respiratory_system0.63938521
75MP0005058_abnormal_lysosome_morphology0.63421897
76MP0005334_abnormal_fat_pad0.62814287
77MP0000049_abnormal_middle_ear0.62525765
78MP0009780_abnormal_chondrocyte_physiolo0.62406579
79MP0004270_analgesia0.61341237
80MP0000516_abnormal_urinary_system0.60144627
81MP0005367_renal/urinary_system_phenotyp0.60144627
82MP0002735_abnormal_chemical_nociception0.59780757
83MP0004272_abnormal_basement_membrane0.59447626
84MP0000343_altered_response_to0.58248960
85MP0002733_abnormal_thermal_nociception0.57517226
86MP0000681_abnormal_thyroid_gland0.56916287
87MP0009278_abnormal_bone_marrow0.56772180
88MP0000569_abnormal_digit_pigmentation0.55422045
89MP0000470_abnormal_stomach_morphology0.54809128
90MP0002736_abnormal_nociception_after0.53986989
91MP0004811_abnormal_neuron_physiology0.53771389
92MP0003011_delayed_dark_adaptation0.53537413
93MP0002572_abnormal_emotion/affect_behav0.52282895
94MP0005551_abnormal_eye_electrophysiolog0.51678249
95MP0004036_abnormal_muscle_relaxation0.51531496
96MP0000358_abnormal_cell_content/0.50253723
97MP0000751_myopathy0.49867354
98MP0003786_premature_aging0.49858516
99MP0010094_abnormal_chromosome_stability0.49469297
100MP0001968_abnormal_touch/_nociception0.49425439
101MP0002928_abnormal_bile_duct0.49376965
102MP0002102_abnormal_ear_morphology0.48501280
103MP0003633_abnormal_nervous_system0.48187536
104MP0001486_abnormal_startle_reflex0.47392532
105MP0002152_abnormal_brain_morphology0.47267564
106MP0003635_abnormal_synaptic_transmissio0.47203994
107MP0002272_abnormal_nervous_system0.47195975
108MP0003861_abnormal_nervous_system0.45746003
109MP0004742_abnormal_vestibular_system0.45446770
110MP0003879_abnormal_hair_cell0.45363214
111MP0001324_abnormal_eye_pigmentation0.45328717
112MP0002063_abnormal_learning/memory/cond0.44734286
113MP0005646_abnormal_pituitary_gland0.44512732
114MP0005253_abnormal_eye_physiology0.44218410
115MP0005397_hematopoietic_system_phenotyp0.44123669
116MP0001545_abnormal_hematopoietic_system0.44123669
117MP0005636_abnormal_mineral_homeostasis0.43833216
118MP0003699_abnormal_female_reproductive0.43520032
119MP0001293_anophthalmia0.43112005
120MP0008961_abnormal_basal_metabolism0.42567697
121MP0001440_abnormal_grooming_behavior0.42250532
122MP0003880_abnormal_central_pattern0.40875321
123MP0003329_amyloid_beta_deposits0.40256535
124MP0009745_abnormal_behavioral_response0.39480920
125MP0001986_abnormal_taste_sensitivity0.39397802
126MP0008007_abnormal_cellular_replicative0.38725201
127MP0002557_abnormal_social/conspecific_i0.38043508
128MP0003631_nervous_system_phenotype0.37373512
129MP0006276_abnormal_autonomic_nervous0.36602178
130MP0005394_taste/olfaction_phenotype0.36278294
131MP0005499_abnormal_olfactory_system0.36278294
132MP0005666_abnormal_adipose_tissue0.34998755
133MP0005391_vision/eye_phenotype0.34488405
134MP0004133_heterotaxia0.33012830
135MP0009115_abnormal_fat_cell0.32823973
136MP0000955_abnormal_spinal_cord0.32707386
137MP0002734_abnormal_mechanical_nocicepti0.32272850
138MP0000534_abnormal_ureter_morphology0.32244504
139MP0000778_abnormal_nervous_system0.31782452
140MP0003948_abnormal_gas_homeostasis0.31743692
141MP0001764_abnormal_homeostasis0.31643246
142MP0002229_neurodegeneration0.30608471
143MP0002067_abnormal_sensory_capabilities0.30422953
144MP0001529_abnormal_vocalization0.30358492
145MP0001119_abnormal_female_reproductive0.30335625
146MP0003045_fibrosis0.29931265
147MP0002269_muscular_atrophy0.29001631
148MP0002064_seizures0.28419398
149MP0002882_abnormal_neuron_morphology0.28418998
150MP0008569_lethality_at_weaning0.28255314
151MP0004808_abnormal_hematopoietic_stem0.27368124
152MP0004134_abnormal_chest_morphology0.26848711
153MP0001727_abnormal_embryo_implantation0.26499406
154MP0002971_abnormal_brown_adipose0.26323940
155MP0002752_abnormal_somatic_nervous0.26297321
156MP0006036_abnormal_mitochondrial_physio0.25093093

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.38084971
2Abnormal respiratory motile cilium morphology (HP:0005938)9.05520438
3Abnormal respiratory epithelium morphology (HP:0012253)9.05520438
4Rhinitis (HP:0012384)7.80185451
5Abnormal ciliary motility (HP:0012262)7.54877688
6Resting tremor (HP:0002322)7.32172932
7Chronic bronchitis (HP:0004469)6.98816216
8Infertility (HP:0000789)6.63181036
9Nasal polyposis (HP:0100582)6.15847865
10Abnormality of the nasal mucosa (HP:0000433)5.12945762
11Severe visual impairment (HP:0001141)4.82931450
12Postural instability (HP:0002172)4.69034203
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.64875258
14Nephronophthisis (HP:0000090)4.55583493
15Bronchiectasis (HP:0002110)4.52227797
16Bronchitis (HP:0012387)4.51171486
17Attenuation of retinal blood vessels (HP:0007843)3.96739642
18Male infertility (HP:0003251)3.90714781
19Bony spicule pigmentary retinopathy (HP:0007737)3.79939826
20Abnormality of the renal medulla (HP:0100957)3.44990073
21Recurrent otitis media (HP:0000403)3.28572950
22Abnormal spermatogenesis (HP:0008669)3.17053556
23Hyperkalemia (HP:0002153)3.15360046
24Cone-rod dystrophy (HP:0000548)3.14625734
25Recurrent sinusitis (HP:0011108)3.14140627
26Asymmetric septal hypertrophy (HP:0001670)3.06404039
27Abnormal rod and cone electroretinograms (HP:0008323)3.02514409
28Ulnar claw (HP:0001178)2.96856973
29Abnormality of macular pigmentation (HP:0008002)2.92162196
30Atonic seizures (HP:0010819)2.91634301
31Recurrent bronchitis (HP:0002837)2.86075000
32Chronic hepatic failure (HP:0100626)2.85561036
33Abnormal sex determination (HP:0012244)2.79715864
34Sex reversal (HP:0012245)2.79715864
35Molar tooth sign on MRI (HP:0002419)2.73312765
36Abnormality of midbrain morphology (HP:0002418)2.73312765
37Gonadotropin excess (HP:0000837)2.71097592
38Tubulointerstitial nephritis (HP:0001970)2.70772276
39Potter facies (HP:0002009)2.68748985
40Facial shape deformation (HP:0011334)2.68748985
41Hypoplastic ischia (HP:0003175)2.67409325
42Abnormality of the lower motor neuron (HP:0002366)2.65556166
43Impulsivity (HP:0100710)2.62210126
44Medial flaring of the eyebrow (HP:0010747)2.59311109
45Double outlet right ventricle (HP:0001719)2.58837151
46Congenital malformation of the right heart (HP:0011723)2.58837151
47Tubular atrophy (HP:0000092)2.49550975
48Abnormality of the ischium (HP:0003174)2.49250838
49Menorrhagia (HP:0000132)2.44564532
50Tubulointerstitial abnormality (HP:0001969)2.40117987
51Hyporeflexia of lower limbs (HP:0002600)2.32496749
52Enlarged epiphyses (HP:0010580)2.31475292
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30014880
54Portal hypertension (HP:0001409)2.26074173
55Congenital sensorineural hearing impairment (HP:0008527)2.24999275
56Optic nerve hypoplasia (HP:0000609)2.19623209
57Abnormality of lateral ventricle (HP:0030047)2.19313946
58Azoospermia (HP:0000027)2.17368538
59Sensory axonal neuropathy (HP:0003390)2.17119673
60Prolonged bleeding time (HP:0003010)2.12778746
61Abnormality of the hepatic vasculature (HP:0006707)2.12328678
62Truncal obesity (HP:0001956)2.12232526
63Postaxial foot polydactyly (HP:0001830)2.11820649
64Generalized aminoaciduria (HP:0002909)2.11384244
65Hypophosphatemic rickets (HP:0004912)2.08666916
66Amyotrophic lateral sclerosis (HP:0007354)2.08212738
67Aplasia/Hypoplasia of the earlobes (HP:0009906)2.06869156
68Fibular hypoplasia (HP:0003038)2.05960039
69Bradykinesia (HP:0002067)2.05478307
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3269281
71Dynein arm defect of respiratory motile cilia (HP:0012255)12.9553350
72Absent/shortened dynein arms (HP:0200106)12.9553350
73Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99901556
74Tubulointerstitial fibrosis (HP:0005576)1.99261907
75Spastic tetraparesis (HP:0001285)1.97662528
76Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.97323580
77Progressive cerebellar ataxia (HP:0002073)1.96968979
78Clumsiness (HP:0002312)1.95063689
79Urinary urgency (HP:0000012)1.94616495
80Congenital hepatic fibrosis (HP:0002612)1.92861655
81Stage 5 chronic kidney disease (HP:0003774)1.92440294
82Rhabdomyolysis (HP:0003201)1.90230702
83Abnormality of dental color (HP:0011073)1.89790611
84Abnormal gallbladder physiology (HP:0012438)1.86126794
85Cholecystitis (HP:0001082)1.86126794
86Atelectasis (HP:0100750)1.85674780
87Gonadal dysgenesis (HP:0000133)1.85353759
88Bulbous nose (HP:0000414)1.83575886
89Abnormality of potassium homeostasis (HP:0011042)1.82360814
90Difficulty walking (HP:0002355)1.80884956
91Ventricular fibrillation (HP:0001663)1.80201935
92Cerebellar dysplasia (HP:0007033)1.74875343
93Short ribs (HP:0000773)1.74785732
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73740737
95Polydipsia (HP:0001959)1.72268315
96Abnormal drinking behavior (HP:0030082)1.72268315
97Dyschromatopsia (HP:0007641)1.71683665
98Hypoalphalipoproteinemia (HP:0003233)1.71184071
99Renal dysplasia (HP:0000110)1.70548680
100Retinal atrophy (HP:0001105)1.70320061
101Heterotopia (HP:0002282)1.70116701
102Anterior segment dysgenesis (HP:0007700)1.70070052
103Oculomotor apraxia (HP:0000657)1.69720562
104Myoglobinuria (HP:0002913)1.69621016
105Neoplasm of the heart (HP:0100544)1.69039940
106Polyuria (HP:0000103)1.67694332
107Exocrine pancreatic insufficiency (HP:0001738)1.67434856
108Impaired proprioception (HP:0010831)1.66780370
109Osteomalacia (HP:0002749)1.66766976
110Atrial fibrillation (HP:0005110)1.66631617
111Facial hemangioma (HP:0000329)1.66602668
112Chronic sinusitis (HP:0011109)1.66415559
113Male pseudohermaphroditism (HP:0000037)1.65387265
114Choroideremia (HP:0001139)1.65153182
115Segmental peripheral demyelination/remyelination (HP:0003481)1.64982753
116Postaxial hand polydactyly (HP:0001162)1.64896176
117Tetany (HP:0001281)1.64671218
118Decreased central vision (HP:0007663)1.63974507
119Colitis (HP:0002583)1.63651128
120Recurrent corneal erosions (HP:0000495)1.62477271
121Spinal rigidity (HP:0003306)1.62353069
122J-shaped sella turcica (HP:0002680)1.61789492
123Flattened epiphyses (HP:0003071)1.61757910
124Glycosuria (HP:0003076)1.61499947
125Absent frontal sinuses (HP:0002688)1.61438769
126Abnormality of the renal cortex (HP:0011035)1.60117656
127Abnormal biliary tract physiology (HP:0012439)1.57378338
128Bile duct proliferation (HP:0001408)1.57378338
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56287939
130Absent epiphyses (HP:0010577)1.56287939
131Bell-shaped thorax (HP:0001591)1.55620755
132Microglossia (HP:0000171)1.54849344
133Abnormality of the dental root (HP:0006486)1.52578245
134Taurodontia (HP:0000679)1.52578245
135Abnormality of permanent molar morphology (HP:0011071)1.52578245
136Facial cleft (HP:0002006)1.52269632
137Gait imbalance (HP:0002141)1.51633596
138Abnormality of renal excretion (HP:0011036)1.48969931
139Hemiparesis (HP:0001269)1.47776399
140Aplasia/Hypoplasia of the lens (HP:0008063)1.47390579
141Abnormality of dentin (HP:0010299)1.47126596
142Congenital primary aphakia (HP:0007707)1.45748441
143Abnormality of molar morphology (HP:0011070)1.42593607
144Abnormality of molar (HP:0011077)1.42593607
145Pancreatic fibrosis (HP:0100732)1.42514533
146Pachygyria (HP:0001302)1.40716300
147Supernumerary spleens (HP:0009799)1.40241470
148Abnormality of the dental pulp (HP:0006479)1.37954254
149Cystic liver disease (HP:0006706)1.37110440
150Abnormality of ocular smooth pursuit (HP:0000617)1.35925965
151Deformed sella turcica (HP:0002681)1.35803685
152Aplasia/Hypoplasia of the fibula (HP:0006492)1.35555639
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.34681502
154Hemorrhage of the eye (HP:0011885)1.33927721
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.33754679
156Median cleft lip (HP:0000161)1.33572946
157Short thorax (HP:0010306)1.33059342
158Retinal dysplasia (HP:0007973)1.29357518
159Nephropathy (HP:0000112)1.27531522
160Lissencephaly (HP:0001339)1.25033460
161Neurofibrillary tangles (HP:0002185)1.23083348
162Nephrogenic diabetes insipidus (HP:0009806)1.22150388
163Exercise-induced myalgia (HP:0003738)1.21616010
164True hermaphroditism (HP:0010459)1.18631004
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.18331035
166Abnormal urine output (HP:0012590)1.17402511
167Abnormality of saccadic eye movements (HP:0000570)1.16797385
168Abnormality of the anterior horn cell (HP:0006802)1.15069690
169Degeneration of anterior horn cells (HP:0002398)1.15069690
170Gaze-evoked nystagmus (HP:0000640)1.14755514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.27246698
2PDK48.27246698
3TESK15.43481605
4PDK25.31793834
5PRKD34.96683892
6ICK3.97464675
7MAP4K22.89000186
8MAP3K132.66737532
9WNK42.54770637
10PNCK2.53245652
11PTK2B2.49184520
12DDR22.36335795
13STK392.34452780
14OBSCN1.95252199
15TGFBR11.87942643
16INSRR1.76789301
17STK381.71336549
18MAP3K91.66209571
19NEK21.62112829
20LATS21.61531871
21MYLK1.56628156
22MAPK151.53216997
23ARAF1.47284422
24DYRK1B1.41169637
25PIM21.36455004
26TLK11.33181725
27MAP3K11.31867297
28PLK21.27492088
29KSR21.26989212
30PIK3CG1.20892183
31ZAK1.19001902
32CDK81.18914976
33WNK11.18597542
34LATS11.14096347
35SGK4941.10688278
36SGK2231.10688278
37CDK121.06733792
38PDK11.01755950
39BRD40.99287462
40RPS6KA50.98566329
41TYRO30.96823523
42CCNB10.93124086
43BRAF0.91043494
44MST1R0.88415781
45MOS0.79869682
46DYRK30.79777807
47PKN10.77667123
48MAP3K50.74789139
49ROCK10.73249407
50MET0.69994807
51STK30.67463927
52BMPR1B0.67185736
53SGK20.67074967
54NTRK20.66932731
55PRKG20.66072182
56CAMK1G0.62690432
57PINK10.62462334
58PRKAA20.62394562
59MAP3K20.62309743
60PASK0.62121871
61IRAK10.60107795
62RET0.57749176
63PDPK10.53005473
64ADRBK20.51601669
65MARK10.50765114
66RPS6KA20.48721693
67CAMK10.48576601
68TTK0.46754799
69CDK70.46389888
70MAP3K40.45855247
71MAP2K60.44957108
72MAPK10.44230861
73FRK0.44130940
74STK38L0.44020397
75EIF2AK30.43598100
76CHEK20.41046855
77CHEK10.40075381
78MAP3K70.39816157
79MUSK0.37996824
80PLK40.37978654
81LMTK20.37410850
82IRAK20.36586057
83ACVR1B0.36349394
84TAOK30.35443831
85PRKCG0.34598921
86CDC70.34277940
87CDK90.33976047
88MARK20.33323736
89ATM0.29926656
90MAPK120.29773928
91RIPK40.29715349
92ATR0.28870333
93SIK20.28240983
94FES0.27448617
95PAK10.26048428
96CAMK40.26031154
97SGK30.25408077
98MAP2K70.25073926
99BMX0.24720002
100PAK20.24676136
101MAP3K80.24609151
102PAK60.24155851
103PRKAA10.24009792
104MTOR0.23736862
105RPS6KA60.23704775
106NTRK30.22847802
107MAPKAPK50.22105547
108STK110.21936415
109RPS6KB10.21925279
110STK160.21242440
111WEE10.20881369
112MAP3K100.20733123
113TIE10.20729673
114DAPK30.20330891
115NEK60.20199633
116SGK10.19586313
117EEF2K0.19049138
118RIPK10.18227761
119CAMKK10.17830970
120CDK30.17814569
121TESK20.17192796
122PRKCZ0.14779865
123WNK30.13426115
124CAMK2A0.12624098
125CDK150.12452684
126MINK10.11611347
127CDK180.10354694
128GSK3B0.09300216
129PLK10.08922592
130PRKG10.08873732
131MAPK80.08836196
132CDK11A0.08072195
133PRKCQ0.07534826
134EPHA40.06062655
135CDK140.06054806
136PAK40.05485468
137CDK10.05386723
138PHKG10.05336402
139PHKG20.05336402
140CSNK1D0.03846149
141MAPK130.03191295
142DAPK20.03088626
143PRKACB0.02941433
144CDK50.02913427
145CDK20.02684080
146PRKCB0.02642045
147PRKACG0.02616785
148ERBB30.02220902
149CSNK2A10.01753578
150RPS6KA30.00903455
151TAOK10.00674639
152RPS6KA10.00398450
153PRKCA-0.0148726
154MARK3-0.0119949
155PRKDC-0.0048854
156YES1-0.0034362
157TRIB3-0.0009509

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.65911954
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97748539
3Fatty acid biosynthesis_Homo sapiens_hsa000613.60002931
4Vitamin B6 metabolism_Homo sapiens_hsa007503.59159710
5Pyruvate metabolism_Homo sapiens_hsa006203.59117976
6Glucagon signaling pathway_Homo sapiens_hsa049222.88974455
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76797916
8Propanoate metabolism_Homo sapiens_hsa006402.71105519
9Linoleic acid metabolism_Homo sapiens_hsa005912.64438156
10Dorso-ventral axis formation_Homo sapiens_hsa043202.50797121
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.48478374
12Basal transcription factors_Homo sapiens_hsa030222.43058141
13Gap junction_Homo sapiens_hsa045402.41315781
14Butanoate metabolism_Homo sapiens_hsa006502.26742457
15Amphetamine addiction_Homo sapiens_hsa050312.21316585
16Nitrogen metabolism_Homo sapiens_hsa009102.05314532
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01983892
18Oocyte meiosis_Homo sapiens_hsa041141.97445469
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92347444
20Glycerolipid metabolism_Homo sapiens_hsa005611.86347741
21Huntingtons disease_Homo sapiens_hsa050161.80886951
22Renin secretion_Homo sapiens_hsa049241.70538381
23Fanconi anemia pathway_Homo sapiens_hsa034601.68117637
24Selenocompound metabolism_Homo sapiens_hsa004501.66100606
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66088890
26Circadian rhythm_Homo sapiens_hsa047101.65964535
27Cardiac muscle contraction_Homo sapiens_hsa042601.65663516
28Arginine biosynthesis_Homo sapiens_hsa002201.64851388
29Phenylalanine metabolism_Homo sapiens_hsa003601.54888417
30Pentose phosphate pathway_Homo sapiens_hsa000301.53730803
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50450267
32PPAR signaling pathway_Homo sapiens_hsa033201.50173295
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.49338022
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47284046
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46445238
36Phototransduction_Homo sapiens_hsa047441.45419296
37Long-term potentiation_Homo sapiens_hsa047201.35407499
38mRNA surveillance pathway_Homo sapiens_hsa030151.35215136
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29262687
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26307807
41Ether lipid metabolism_Homo sapiens_hsa005651.23977192
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.20887497
43Fructose and mannose metabolism_Homo sapiens_hsa000511.20090389
44Insulin secretion_Homo sapiens_hsa049111.14075800
45Fat digestion and absorption_Homo sapiens_hsa049751.12732996
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11252437
47Taste transduction_Homo sapiens_hsa047421.11039107
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.07584776
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05755458
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.03850246
51Mineral absorption_Homo sapiens_hsa049781.02873479
52Arginine and proline metabolism_Homo sapiens_hsa003301.00720665
53Fatty acid metabolism_Homo sapiens_hsa012120.99913528
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99660188
55Olfactory transduction_Homo sapiens_hsa047400.99645263
56Platelet activation_Homo sapiens_hsa046110.98925137
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98464496
58Estrogen signaling pathway_Homo sapiens_hsa049150.97159769
59Calcium signaling pathway_Homo sapiens_hsa040200.96242338
60ECM-receptor interaction_Homo sapiens_hsa045120.94082776
61Circadian entrainment_Homo sapiens_hsa047130.93515439
62Serotonergic synapse_Homo sapiens_hsa047260.92093923
63RNA transport_Homo sapiens_hsa030130.91978992
64GABAergic synapse_Homo sapiens_hsa047270.91551657
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90474360
66Carbon metabolism_Homo sapiens_hsa012000.89769341
67Synaptic vesicle cycle_Homo sapiens_hsa047210.89523789
68Purine metabolism_Homo sapiens_hsa002300.87589972
69Nicotine addiction_Homo sapiens_hsa050330.87256897
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86929099
71Retinol metabolism_Homo sapiens_hsa008300.84396037
72Collecting duct acid secretion_Homo sapiens_hsa049660.84286474
73Fatty acid degradation_Homo sapiens_hsa000710.81610447
74Cocaine addiction_Homo sapiens_hsa050300.80355190
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79457034
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78957481
77Tyrosine metabolism_Homo sapiens_hsa003500.77326439
78Phagosome_Homo sapiens_hsa041450.77105816
79Antigen processing and presentation_Homo sapiens_hsa046120.74484079
80Hedgehog signaling pathway_Homo sapiens_hsa043400.72556454
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71908639
82Glutamatergic synapse_Homo sapiens_hsa047240.70950917
83Salivary secretion_Homo sapiens_hsa049700.69804311
84Cholinergic synapse_Homo sapiens_hsa047250.69585173
85Complement and coagulation cascades_Homo sapiens_hsa046100.68780701
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68758374
87ABC transporters_Homo sapiens_hsa020100.68213172
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67336859
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67233991
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.66918915
91Dilated cardiomyopathy_Homo sapiens_hsa054140.66156008
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.64030682
93MAPK signaling pathway_Homo sapiens_hsa040100.62409833
94Dopaminergic synapse_Homo sapiens_hsa047280.60926229
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.59674022
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59621779
97Apoptosis_Homo sapiens_hsa042100.59182335
98Thyroid hormone synthesis_Homo sapiens_hsa049180.58808391
99cAMP signaling pathway_Homo sapiens_hsa040240.56326872
100Systemic lupus erythematosus_Homo sapiens_hsa053220.56017107
101Gastric acid secretion_Homo sapiens_hsa049710.55246556
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54651787
103Tight junction_Homo sapiens_hsa045300.54485491
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53595123
105Arachidonic acid metabolism_Homo sapiens_hsa005900.53137526
106VEGF signaling pathway_Homo sapiens_hsa043700.53036045
107Inositol phosphate metabolism_Homo sapiens_hsa005620.52999004
108AMPK signaling pathway_Homo sapiens_hsa041520.49515217
109Tryptophan metabolism_Homo sapiens_hsa003800.49122015
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48942383
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48067369
112Endocytosis_Homo sapiens_hsa041440.47753224
113Bile secretion_Homo sapiens_hsa049760.47731433
114Pancreatic secretion_Homo sapiens_hsa049720.46982740
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.44519137
116Morphine addiction_Homo sapiens_hsa050320.43291034
117Focal adhesion_Homo sapiens_hsa045100.42668820
118beta-Alanine metabolism_Homo sapiens_hsa004100.41780619
119Insulin resistance_Homo sapiens_hsa049310.41611205
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41533277
121Insulin signaling pathway_Homo sapiens_hsa049100.41334448
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40782342
123Histidine metabolism_Homo sapiens_hsa003400.39160898
124Chemical carcinogenesis_Homo sapiens_hsa052040.38512126
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37403560
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37267878
127N-Glycan biosynthesis_Homo sapiens_hsa005100.36683394
128Biosynthesis of amino acids_Homo sapiens_hsa012300.36258657
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36023757
130Alcoholism_Homo sapiens_hsa050340.35946432
131Oxytocin signaling pathway_Homo sapiens_hsa049210.35805333
132Glutathione metabolism_Homo sapiens_hsa004800.35261465
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35108366
134Renin-angiotensin system_Homo sapiens_hsa046140.33299157
135Wnt signaling pathway_Homo sapiens_hsa043100.31652040
136Legionellosis_Homo sapiens_hsa051340.30168820
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28045096
138Metabolic pathways_Homo sapiens_hsa011000.23433070
139Alzheimers disease_Homo sapiens_hsa050100.23353251
140Type II diabetes mellitus_Homo sapiens_hsa049300.23325068
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22026636
142Protein digestion and absorption_Homo sapiens_hsa049740.21244965

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