ACP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)6.18098118
2oligosaccharide catabolic process (GO:0009313)5.92402017
3glycolipid catabolic process (GO:0019377)5.57444082
4amino sugar catabolic process (GO:0046348)5.35449113
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.19750135
6L-phenylalanine catabolic process (GO:0006559)5.19750135
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18248066
8cellular response to thyroid hormone stimulus (GO:0097067)5.05756716
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.02558759
10L-phenylalanine metabolic process (GO:0006558)5.02558759
11ceramide catabolic process (GO:0046514)4.98189916
12aromatic amino acid family catabolic process (GO:0009074)4.84188588
13complement activation, alternative pathway (GO:0006957)4.74326083
14regulation of mononuclear cell migration (GO:0071675)4.69104803
15alpha-linolenic acid metabolic process (GO:0036109)4.65051153
16tryptophan catabolic process (GO:0006569)4.50243547
17indole-containing compound catabolic process (GO:0042436)4.50243547
18indolalkylamine catabolic process (GO:0046218)4.50243547
19neutrophil activation involved in immune response (GO:0002283)4.48406094
20response to peptidoglycan (GO:0032494)4.48348778
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.42458909
22urea metabolic process (GO:0019627)4.40704559
23urea cycle (GO:0000050)4.40704559
24plasma lipoprotein particle clearance (GO:0034381)4.37894285
25regulation of triglyceride catabolic process (GO:0010896)4.36381828
26sulfur amino acid catabolic process (GO:0000098)4.35663445
27kynurenine metabolic process (GO:0070189)4.31865143
28cysteine metabolic process (GO:0006534)4.29693100
29tryptophan metabolic process (GO:0006568)4.25332142
30bile acid biosynthetic process (GO:0006699)4.20980033
31peptidyl-glutamic acid carboxylation (GO:0017187)4.16005310
32protein carboxylation (GO:0018214)4.16005310
33N-acetylneuraminate metabolic process (GO:0006054)4.15621808
34regulation of protein activation cascade (GO:2000257)4.13792945
35low-density lipoprotein particle clearance (GO:0034383)4.09482616
36glyoxylate metabolic process (GO:0046487)4.05175314
37nitrogen cycle metabolic process (GO:0071941)4.03341310
38response to thyroid hormone (GO:0097066)4.01455357
39high-density lipoprotein particle remodeling (GO:0034375)4.01347594
40membrane lipid catabolic process (GO:0046466)4.01086917
41negative regulation of fibrinolysis (GO:0051918)3.99522401
42regulation of complement activation (GO:0030449)3.94727054
43regulation of fibrinolysis (GO:0051917)3.93570846
44sphingolipid catabolic process (GO:0030149)3.92585117
45immunoglobulin mediated immune response (GO:0016064)3.90320369
46positive regulation of monocyte chemotaxis (GO:0090026)3.88891503
47phospholipid efflux (GO:0033700)3.88698976
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.87360528
49triglyceride homeostasis (GO:0070328)3.80994950
50acylglycerol homeostasis (GO:0055090)3.80994950
51homocysteine metabolic process (GO:0050667)3.77730313
52T-helper 1 type immune response (GO:0042088)3.76669068
53macrophage activation involved in immune response (GO:0002281)3.74729978
54* negative regulation of interleukin-12 production (GO:0032695)3.74711658
55lysine metabolic process (GO:0006553)3.73309917
56lysine catabolic process (GO:0006554)3.73309917
57positive regulation of lipid catabolic process (GO:0050996)3.71832569
58serine family amino acid catabolic process (GO:0009071)3.71315523
59regulation of cholesterol esterification (GO:0010872)3.71051117
60bile acid metabolic process (GO:0008206)3.69042584
61protein-lipid complex remodeling (GO:0034368)3.68389555
62macromolecular complex remodeling (GO:0034367)3.68389555
63plasma lipoprotein particle remodeling (GO:0034369)3.68389555
64reverse cholesterol transport (GO:0043691)3.67911976
65myeloid dendritic cell differentiation (GO:0043011)3.67216385
66amino-acid betaine metabolic process (GO:0006577)3.65353005
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64938423
68barbed-end actin filament capping (GO:0051016)3.64738955
69valine metabolic process (GO:0006573)3.63746598
70positive regulation of gamma-delta T cell activation (GO:0046645)3.58909409
71positive regulation of leukocyte degranulation (GO:0043302)3.55708461
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49698694
73plasma lipoprotein particle assembly (GO:0034377)3.49255818
74aromatic amino acid family metabolic process (GO:0009072)3.47933681
75negative regulation of cholesterol transport (GO:0032375)3.47544684
76negative regulation of sterol transport (GO:0032372)3.47544684
77positive regulation of antigen processing and presentation (GO:0002579)3.46934254
78positive regulation of triglyceride lipase activity (GO:0061365)3.45400687
79positive regulation of lipoprotein lipase activity (GO:0051006)3.45400687
80regulation of macrophage chemotaxis (GO:0010758)3.44438569
81regulation of cholesterol storage (GO:0010885)3.40719420
82regulation of mast cell degranulation (GO:0043304)3.39312814
83positive regulation of mast cell activation (GO:0033005)3.37415221
84positive regulation of cholesterol efflux (GO:0010875)3.36724013
85positive regulation of mast cell degranulation (GO:0043306)3.36548458
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.36548458
87fat-soluble vitamin biosynthetic process (GO:0042362)3.36517638
88cholesterol efflux (GO:0033344)3.35126783
89tyrosine metabolic process (GO:0006570)3.34784923
90aldehyde catabolic process (GO:0046185)3.34753029
91ethanol oxidation (GO:0006069)3.34094999
92myeloid dendritic cell activation (GO:0001773)3.33204092
93complement activation (GO:0006956)3.29573286
94fatty acid beta-oxidation (GO:0006635)3.29544927
95acetyl-CoA metabolic process (GO:0006084)3.27779652
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.26320013
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.25811889
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24864456
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24864456
100positive regulation of cellular amide metabolic process (GO:0034250)3.22991935
101alpha-amino acid catabolic process (GO:1901606)3.22923448
102phospholipid homeostasis (GO:0055091)3.22866165
103antigen processing and presentation of endogenous antigen (GO:0019883)3.22346738
104NIK/NF-kappaB signaling (GO:0038061)3.21293812
105detection of molecule of bacterial origin (GO:0032490)3.20094264
106fatty acid oxidation (GO:0019395)3.19998857
107protein-lipid complex assembly (GO:0065005)3.19202124
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.18355162
109regulation of monocyte chemotaxis (GO:0090025)3.16552486
110monocyte chemotaxis (GO:0002548)3.16285180
111complement activation, classical pathway (GO:0006958)3.16009900
112lipid oxidation (GO:0034440)3.16001893
113phagosome maturation (GO:0090382)3.14568709
114very-low-density lipoprotein particle assembly (GO:0034379)3.13151748
115acute-phase response (GO:0006953)3.13026233
116regulation of leukocyte degranulation (GO:0043300)3.12811340
117regulation of antigen processing and presentation (GO:0002577)3.12235103
118cholesterol homeostasis (GO:0042632)3.11105412
119plasma lipoprotein particle organization (GO:0071827)3.11079159
120interferon-gamma-mediated signaling pathway (GO:0060333)3.11076965
121regulation of mast cell activation involved in immune response (GO:0033006)3.10312321
122bile acid and bile salt transport (GO:0015721)3.10241561
123regulation of vitamin D biosynthetic process (GO:0060556)3.09860607
124fibrinolysis (GO:0042730)3.08889455
125positive regulation of triglyceride metabolic process (GO:0090208)3.08625952
126regulation of cholesterol homeostasis (GO:2000188)3.08255957
127indolalkylamine metabolic process (GO:0006586)3.07924003
128detection of other organism (GO:0098543)3.07813747
129granulocyte activation (GO:0036230)3.07212738
130sterol homeostasis (GO:0055092)3.06590908
131protein activation cascade (GO:0072376)3.06194918
132positive regulation of chemokine biosynthetic process (GO:0045080)3.05857137
133cytolysis (GO:0019835)3.05651097
134keratan sulfate catabolic process (GO:0042340)3.05059989
135glycine metabolic process (GO:0006544)3.04736024
136amine catabolic process (GO:0009310)3.03451703
137cellular biogenic amine catabolic process (GO:0042402)3.03451703
138fatty acid catabolic process (GO:0009062)3.03419128
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01825795
140positive regulation by organism of defense response of other organism involved in symbiotic interact3.01825795
141modulation by symbiont of host immune response (GO:0052553)3.01825795
142positive regulation by symbiont of host defense response (GO:0052509)3.01825795
143modulation by symbiont of host defense response (GO:0052031)3.01825795
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01825795
145cofactor catabolic process (GO:0051187)3.00985426
146cellular glucuronidation (GO:0052695)3.00925369
147cellular amino acid catabolic process (GO:0009063)3.00544588
148dendritic cell differentiation (GO:0097028)2.99710350
149serine family amino acid metabolic process (GO:0009069)2.99193341
150cellular ketone body metabolic process (GO:0046950)2.97307146
151low-density lipoprotein particle remodeling (GO:0034374)2.97149399
152benzene-containing compound metabolic process (GO:0042537)2.96821824
1532-oxoglutarate metabolic process (GO:0006103)2.96737670
154protein-lipid complex subunit organization (GO:0071825)2.96091637
155nicotinamide nucleotide biosynthetic process (GO:0019359)2.95752414
156pyridine nucleotide biosynthetic process (GO:0019363)2.95752414
157regulation of sequestering of triglyceride (GO:0010889)2.95660810
158regulation of podosome assembly (GO:0071801)2.95422570
159monocarboxylic acid catabolic process (GO:0072329)2.94186902
160apoptotic cell clearance (GO:0043277)2.94015817
161detection of external biotic stimulus (GO:0098581)2.93704743
162positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90399891
163ganglioside metabolic process (GO:0001573)2.90312183
164peptide catabolic process (GO:0043171)2.88351805
165negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86047861
166negative regulation of cell killing (GO:0031342)2.86047861
167regulation of mast cell activation (GO:0033003)2.85810628
168lysosome organization (GO:0007040)2.84278211
169lytic vacuole organization (GO:0080171)2.84278211
170cellular extravasation (GO:0045123)2.83640382
171macrophage differentiation (GO:0030225)2.83591265
172adhesion of symbiont to host cell (GO:0044650)2.83347744
173virion attachment to host cell (GO:0019062)2.83347744
174respiratory burst (GO:0045730)2.83290199
175hydrogen peroxide biosynthetic process (GO:0050665)2.82047085
176regulation of cytokine secretion involved in immune response (GO:0002739)2.81988372
177pinocytosis (GO:0006907)2.81919784
178eosinophil chemotaxis (GO:0048245)2.81690040
179regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81463227
180cellular response to arsenic-containing substance (GO:0071243)2.81005693
181positive regulation of cholesterol transport (GO:0032376)2.80986736
182positive regulation of sterol transport (GO:0032373)2.80986736
183vitamin D metabolic process (GO:0042359)2.80883638
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79679839
185regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.79518559
186B cell mediated immunity (GO:0019724)2.77837035
187detection of bacterium (GO:0016045)2.75377374
188germinal center formation (GO:0002467)2.75204755
189protein localization to endosome (GO:0036010)2.74755567
190myeloid cell activation involved in immune response (GO:0002275)2.72657171
191macrophage activation (GO:0042116)2.72095674
192mannose metabolic process (GO:0006013)2.71942507
193regulation of membrane protein ectodomain proteolysis (GO:0051043)2.71865744
194negative regulation of cytokine production involved in immune response (GO:0002719)2.69847349
195negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.69147799
196negative regulation of lipid storage (GO:0010888)2.67514632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.99052048
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.74436331
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.72721300
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.18948947
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.60201778
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.43997000
7IRF8_22096565_ChIP-ChIP_GC-B_Human4.21647955
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.62568801
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.54477517
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.88780509
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76860044
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74010368
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.55746991
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49388345
15VDR_24787735_ChIP-Seq_THP-1_Human2.31061189
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21817814
17SPI1_23127762_ChIP-Seq_K562_Human2.18696812
18GATA1_22025678_ChIP-Seq_K562_Human2.11830389
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03870298
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.95998707
21* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92718406
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92655132
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88634368
24CLOCK_20551151_ChIP-Seq_293T_Human1.87861069
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86941245
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86308055
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85672925
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79181595
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.78177404
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75523401
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73791172
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66777375
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63889811
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58708377
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56887941
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55998492
37TFEB_21752829_ChIP-Seq_HELA_Human1.54949389
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54905685
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51254406
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50947806
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45600386
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43407383
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41883673
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36431793
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36024937
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32072365
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31680478
48* MAF_26560356_Chip-Seq_TH1_Human1.27349850
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25817049
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23578646
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20704604
52RUNX_20019798_ChIP-Seq_JUKART_Human1.20639608
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20283488
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15873733
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15864834
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15475669
57TCF7_22412390_ChIP-Seq_EML_Mouse1.13686106
58STAT1_20625510_ChIP-Seq_HELA_Human1.11956676
59KDM2B_26808549_Chip-Seq_DND41_Human1.11585836
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08677133
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08228197
62MYB_26560356_Chip-Seq_TH2_Human1.07970330
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07818395
64* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07584922
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07027765
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.05625043
67* MYB_26560356_Chip-Seq_TH1_Human1.05350623
68GATA1_19941826_ChIP-Seq_K562_Human1.04553492
69* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03379225
70UTX_26944678_Chip-Seq_JUKART_Human1.03353181
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03110470
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02670080
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.00629448
74MYC_22102868_ChIP-Seq_BL_Human0.99677926
75VDR_21846776_ChIP-Seq_THP-1_Human0.99370691
76SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97436247
77GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96561879
78* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95820498
79MAF_26560356_Chip-Seq_TH2_Human0.95763339
80RUNX1_22412390_ChIP-Seq_EML_Mouse0.95088335
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94628033
82SPI1_23547873_ChIP-Seq_NB4_Human0.93025398
83SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92907268
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92770820
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92352858
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90686193
87HNF4A_19822575_ChIP-Seq_HepG2_Human0.90315969
88LXR_22292898_ChIP-Seq_THP-1_Human0.90259378
89TP63_17297297_ChIP-ChIP_HaCaT_Human0.89655410
90VDR_24763502_ChIP-Seq_THP-1_Human0.89102325
91SCL_19346495_ChIP-Seq_HPC-7_Human0.88847427
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88769181
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88687097
94GATA2_19941826_ChIP-Seq_K562_Human0.87863760
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87813870
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.87620258
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87097238
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.86699318
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85954541
100GATA4_25053715_ChIP-Seq_YYC3_Human0.85436736
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84743643
102* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84139284
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.84095362
104KDM2B_26808549_Chip-Seq_K562_Human0.83692346
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83585303
106RACK7_27058665_Chip-Seq_MCF-7_Human0.83298913
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81948067
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81429442
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81233954
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80674863
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80302811
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80276235
113GATA3_27048872_Chip-Seq_THYMUS_Human0.78259231
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78095064
115PU_27001747_Chip-Seq_BMDM_Mouse0.77179026
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75091249
117BCL6_27268052_Chip-Seq_Bcells_Human0.74943857
118BCOR_27268052_Chip-Seq_Bcells_Human0.74244867
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73541263
120P300_27268052_Chip-Seq_Bcells_Human0.73222650
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.71399632
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.69867588
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69730406
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69038891
125EGR1_19032775_ChIP-ChIP_M12_Human0.68437662
126GATA3_26560356_Chip-Seq_TH2_Human0.68061546
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67674841
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67394011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.53871259
2MP0005360_urolithiasis5.45248153
3MP0005365_abnormal_bile_salt4.19710095
4MP0005085_abnormal_gallbladder_physiolo4.05124967
5MP0003172_abnormal_lysosome_physiology3.35357191
6MP0008875_abnormal_xenobiotic_pharmacok3.26173403
7MP0010329_abnormal_lipoprotein_level3.02251098
8MP0009840_abnormal_foam_cell2.91018876
9MP0003191_abnormal_cellular_cholesterol2.89257539
10MP0003806_abnormal_nucleotide_metabolis2.61858537
11MP0003252_abnormal_bile_duct2.54271710
12MP0001835_abnormal_antigen_presentation2.15058791
13MP0004510_myositis2.12445971
14MP0000609_abnormal_liver_physiology2.10371608
15MP0005083_abnormal_biliary_tract2.05748718
16MP0003436_decreased_susceptibility_to2.05717773
17MP0003195_calcinosis2.03594713
18MP0005332_abnormal_amino_acid2.03440133
19MP0005670_abnormal_white_adipose1.96236940
20MP0003656_abnormal_erythrocyte_physiolo1.93894236
21MP0001666_abnormal_nutrient_absorption1.93339525
22MP0003724_increased_susceptibility_to1.89792784
23MP0009785_altered_susceptibility_to1.83986156
24MP0002118_abnormal_lipid_homeostasis1.78993699
25MP0003329_amyloid_beta_deposits1.77531779
26* MP0002998_abnormal_bone_remodeling1.76193202
27MP0003186_abnormal_redox_activity1.72297521
28MP0002138_abnormal_hepatobiliary_system1.69926800
29MP0005310_abnormal_salivary_gland1.69136580
30MP0009278_abnormal_bone_marrow1.64225637
31MP0005319_abnormal_enzyme/_coenzyme1.63374985
32MP0004019_abnormal_vitamin_homeostasis1.62240817
33MP0000685_abnormal_immune_system1.59809681
34MP0006082_CNS_inflammation1.57206994
35MP0005025_abnormal_response_to1.55815444
36MP0009764_decreased_sensitivity_to1.55477500
37MP0005167_abnormal_blood-brain_barrier1.51073153
38* MP0002419_abnormal_innate_immunity1.48305515
39MP0001800_abnormal_humoral_immune1.48116589
40MP0001790_abnormal_immune_system1.47968067
41MP0005387_immune_system_phenotype1.47968067
42MP0008469_abnormal_protein_level1.46860955
43MP0005584_abnormal_enzyme/coenzyme_acti1.46312259
44MP0003705_abnormal_hypodermis_morpholog1.45094672
45MP0005397_hematopoietic_system_phenotyp1.44064943
46MP0001545_abnormal_hematopoietic_system1.44064943
47MP0005000_abnormal_immune_tolerance1.41268436
48MP0005464_abnormal_platelet_physiology1.40606841
49MP0005671_abnormal_response_to1.39697776
50MP0009643_abnormal_urine_homeostasis1.39274699
51MP0004130_abnormal_muscle_cell1.38419484
52MP0005666_abnormal_adipose_tissue1.37933966
53MP0001764_abnormal_homeostasis1.37914288
54MP0003453_abnormal_keratinocyte_physiol1.36279961
55MP0005058_abnormal_lysosome_morphology1.35099737
56MP0004185_abnormal_adipocyte_glucose1.29130872
57MP0005451_abnormal_body_composition1.28452765
58MP0000604_amyloidosis1.27307511
59* MP0002452_abnormal_antigen_presenting1.26323488
60MP0002723_abnormal_immune_serum1.24751057
61MP0001845_abnormal_inflammatory_respons1.24468831
62MP0005257_abnormal_intraocular_pressure1.24219925
63MP0009763_increased_sensitivity_to1.23564525
64MP0002148_abnormal_hypersensitivity_rea1.23139505
65MP0000920_abnormal_myelination1.22649123
66MP0003303_peritoneal_inflammation1.21434746
67MP0006054_spinal_hemorrhage1.20044461
68MP0008260_abnormal_autophagy1.19209405
69MP0001853_heart_inflammation1.17375741
70MP0004947_skin_inflammation1.16067363
71MP0002254_reproductive_system_inflammat1.15996484
72MP0003828_pulmonary_edema1.14573482
73MP0000598_abnormal_liver_morphology1.13510420
74MP0001533_abnormal_skeleton_physiology1.11672759
75MP0002877_abnormal_melanocyte_morpholog1.09485758
76* MP0001819_abnormal_immune_cell1.08521263
77* MP0002420_abnormal_adaptive_immunity1.08432031
78MP0002971_abnormal_brown_adipose1.07923052
79MP0002090_abnormal_vision1.06579207
80MP0008438_abnormal_cutaneous_collagen1.05643005
81MP0002166_altered_tumor_susceptibility1.04121266
82MP0010155_abnormal_intestine_physiology1.03824626
83MP0008004_abnormal_stomach_pH1.02992828
84MP0003183_abnormal_peptide_metabolism0.98115166
85MP0005334_abnormal_fat_pad0.98015447
86MP0009115_abnormal_fat_cell0.96030601
87MP0002405_respiratory_system_inflammati0.95619342
88MP0005636_abnormal_mineral_homeostasis0.94886097
89MP0004883_abnormal_blood_vessel0.93463832
90MP0005165_increased_susceptibility_to0.93097415
91MP0005164_abnormal_response_to0.92848529
92MP0002136_abnormal_kidney_physiology0.92844762
93MP0002006_tumorigenesis0.92749905
94MP0003011_delayed_dark_adaptation0.92360701
95MP0003763_abnormal_thymus_physiology0.91650338
96MP0002876_abnormal_thyroid_physiology0.90199035
97MP0003300_gastrointestinal_ulcer0.89133685
98MP0004147_increased_porphyrin_level0.88874698
99MP0009333_abnormal_splenocyte_physiolog0.87900549
100MP0000371_diluted_coat_color0.87773175
101MP0003634_abnormal_glial_cell0.87367744
102MP0000689_abnormal_spleen_morphology0.87208470
103MP0000716_abnormal_immune_system0.85946198
104MP0003868_abnormal_feces_composition0.84341620
105MP0009642_abnormal_blood_homeostasis0.83263326
106MP0005375_adipose_tissue_phenotype0.81549761
107MP0002398_abnormal_bone_marrow0.81073923
108MP0003279_aneurysm0.79606419
109MP0001756_abnormal_urination0.79208882
110MP0006036_abnormal_mitochondrial_physio0.78250507
111MP0005535_abnormal_body_temperature0.78020456
112MP0005390_skeleton_phenotype0.77362457
113MP0009765_abnormal_xenobiotic_induced0.77034457
114* MP0003795_abnormal_bone_structure0.75822073
115MP0002722_abnormal_immune_system0.75183148
116MP0000858_altered_metastatic_potential0.75006981
117MP0002429_abnormal_blood_cell0.74692720
118MP0000343_altered_response_to0.74473164
119MP0005166_decreased_susceptibility_to0.74455898
120MP0003075_altered_response_to0.74050938
121MP0010307_abnormal_tumor_latency0.73032711
122MP0003091_abnormal_cell_migration0.72982541
123MP0000465_gastrointestinal_hemorrhage0.72873934
124MP0001542_abnormal_bone_strength0.72610179
125MP0001663_abnormal_digestive_system0.71708422
126MP0003690_abnormal_glial_cell0.70114240
127MP0004782_abnormal_surfactant_physiolog0.70018150
128MP0005647_abnormal_sex_gland0.68483978
129MP0005023_abnormal_wound_healing0.67459919
130MP0002837_dystrophic_cardiac_calcinosis0.67061466
131MP0001661_extended_life_span0.66865511
132MP0005275_abnormal_skin_tensile0.66810669
133MP0002970_abnormal_white_adipose0.66514516
134MP0003448_altered_tumor_morphology0.65816213
135MP0000249_abnormal_blood_vessel0.65395630
136MP0003632_abnormal_nervous_system0.65074896
137MP0001851_eye_inflammation0.61990939
138MP0001849_ear_inflammation0.59111198
139MP0003879_abnormal_hair_cell0.58910967
140MP0008874_decreased_physiological_sensi0.57967765
141MP0002933_joint_inflammation0.57472761

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)9.43488216
2Abnormality of liposaccharide metabolism (HP:0010968)9.43488216
3Abnormality of glycosphingolipid metabolism (HP:0004343)9.43488216
4Increased cerebral lipofuscin (HP:0011813)6.20255633
5Dysostosis multiplex (HP:0000943)5.18062823
6Deep venous thrombosis (HP:0002625)5.17336489
7Disinhibition (HP:0000734)5.11430788
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02127050
9Xanthomatosis (HP:0000991)5.01430609
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.98897852
11Complement deficiency (HP:0004431)4.85699388
12Loss of speech (HP:0002371)4.75248536
13Intrahepatic cholestasis (HP:0001406)4.68705248
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65545035
15Prolonged partial thromboplastin time (HP:0003645)4.42307827
16Hypobetalipoproteinemia (HP:0003563)4.33655178
17Hyperlipoproteinemia (HP:0010980)4.26240635
18Neurofibrillary tangles (HP:0002185)4.14452627
19Mutism (HP:0002300)4.05482072
20Abnormality of mucopolysaccharide metabolism (HP:0011020)4.03656938
21Abnormality of polysaccharide metabolism (HP:0011012)4.03656938
22Abnormality of glycosaminoglycan metabolism (HP:0004371)4.03656938
23Joint hemorrhage (HP:0005261)3.99053348
24Recurrent gram-negative bacterial infections (HP:0005420)3.98242459
25Mucopolysacchariduria (HP:0008155)3.87374047
26Urinary glycosaminoglycan excretion (HP:0003541)3.87374047
27Hyperglycinuria (HP:0003108)3.83359151
28Abnormality of complement system (HP:0005339)3.81229554
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.72766859
30Hyperammonemia (HP:0001987)3.71176916
31Systemic lupus erythematosus (HP:0002725)3.64917297
32Hypolipoproteinemia (HP:0010981)3.54773345
33Abnormality of glycine metabolism (HP:0010895)3.45415459
34Abnormality of serine family amino acid metabolism (HP:0010894)3.45415459
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.45068767
36Abnormality of the common coagulation pathway (HP:0010990)3.44203101
37Myocardial infarction (HP:0001658)3.42527732
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41772717
39Epidermoid cyst (HP:0200040)3.39858840
40Hypoalphalipoproteinemia (HP:0003233)3.34135143
41Hyperglycinemia (HP:0002154)3.27540951
42Mediastinal lymphadenopathy (HP:0100721)3.25253972
43Nuclear cataract (HP:0100018)3.24673698
44Agnosia (HP:0010524)3.19781661
45Abnormality of fatty-acid metabolism (HP:0004359)3.17555036
46Abnormality of the vasculature of the conjunctiva (HP:0008054)3.15151413
47Hypoglycemic coma (HP:0001325)3.14427013
48Upper motor neuron abnormality (HP:0002127)3.13356633
49Ketosis (HP:0001946)3.12787590
50Apathy (HP:0000741)3.12264979
51Diminished motivation (HP:0000745)3.07454836
52Abnormality of sulfur amino acid metabolism (HP:0004339)3.06805457
53Hypercholesterolemia (HP:0003124)3.00011197
54Cerebral inclusion bodies (HP:0100314)2.96617199
55Fat malabsorption (HP:0002630)2.94498594
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93025615
57Inappropriate behavior (HP:0000719)2.90733906
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85828960
59Neuronal loss in central nervous system (HP:0002529)2.83655684
60Eczematoid dermatitis (HP:0000976)2.81952516
61Nausea (HP:0002018)2.80444201
62Hyperbilirubinemia (HP:0002904)2.77633893
63Hepatocellular carcinoma (HP:0001402)2.75655402
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74606900
65Abnormality of pyrimidine metabolism (HP:0004353)2.74297085
66Hepatosplenomegaly (HP:0001433)2.71872853
67Abnormality of methionine metabolism (HP:0010901)2.67997309
68Retinal atrophy (HP:0001105)2.67640963
69Pustule (HP:0200039)2.66224627
70Hypertriglyceridemia (HP:0002155)2.65472601
71Progressive neurologic deterioration (HP:0002344)2.62687482
72Abnormality of nucleobase metabolism (HP:0010932)2.59182582
73Recurrent bacterial skin infections (HP:0005406)2.59151220
74Abnormality of the intrinsic pathway (HP:0010989)2.58069298
75Gingival bleeding (HP:0000225)2.55828071
76Chronic obstructive pulmonary disease (HP:0006510)2.55537783
77Obstructive lung disease (HP:0006536)2.55537783
78Hemorrhage of the eye (HP:0011885)2.54045617
79Glomerulonephritis (HP:0000099)2.53835379
80Personality changes (HP:0000751)2.52515199
81Abnormality of purine metabolism (HP:0004352)2.51625331
82Recurrent abscess formation (HP:0002722)2.47933093
83Acanthocytosis (HP:0001927)2.47767448
84Hydroxyprolinuria (HP:0003080)2.43931711
85Abnormality of proline metabolism (HP:0010907)2.43931711
86Dementia (HP:0000726)2.42535862
87Poikilocytosis (HP:0004447)2.38858816
88Orchitis (HP:0100796)2.37038863
89Hypochromic microcytic anemia (HP:0004840)2.36690737
90Dicarboxylic aciduria (HP:0003215)2.36050941
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36050941
92Hematochezia (HP:0002573)2.35651826
93Abnormality of the periventricular white matter (HP:0002518)2.34744156
94Pancreatitis (HP:0001733)2.32827682
95Myositis (HP:0100614)2.30905589
96Steatorrhea (HP:0002570)2.29497033
97Abnormality of iron homeostasis (HP:0011031)2.29086004
98Pathologic fracture (HP:0002756)2.28176126
99Asymmetric septal hypertrophy (HP:0001670)2.28078138
100Conjugated hyperbilirubinemia (HP:0002908)2.25727170
101Peripheral demyelination (HP:0011096)2.24005472
102Cholelithiasis (HP:0001081)2.23606068
103Retrobulbar optic neuritis (HP:0100654)2.22455763
104Optic neuritis (HP:0100653)2.22455763
105Stomatitis (HP:0010280)2.21653032
106Prolonged neonatal jaundice (HP:0006579)2.21269625
107Metabolic acidosis (HP:0001942)2.20869340
108Ketoacidosis (HP:0001993)2.20001221
109Abnormality of serum amino acid levels (HP:0003112)2.19426903
110Elevated erythrocyte sedimentation rate (HP:0003565)2.18872511
111Global brain atrophy (HP:0002283)2.18578723
112Mitral stenosis (HP:0001718)2.17659103
113Abnormal gallbladder morphology (HP:0012437)2.17583729
114Increased serum ferritin (HP:0003281)2.16717798
115Gingivitis (HP:0000230)2.16706579
116Amyloidosis (HP:0011034)2.16464939
117Skin nodule (HP:0200036)2.15620787
118Abnormality of transition element cation homeostasis (HP:0011030)2.14630052
119Esophageal varix (HP:0002040)2.13320550
120Vascular calcification (HP:0004934)2.12712315
121Pulmonary infiltrates (HP:0002113)2.12588939
122Nephritis (HP:0000123)2.12220162
123Generalized aminoaciduria (HP:0002909)2.11783705
124Petechiae (HP:0000967)2.11373614
125Vacuolated lymphocytes (HP:0001922)2.11102349
126Spontaneous hematomas (HP:0007420)2.10210078
127Bone pain (HP:0002653)2.08678174
128Cardiomegaly (HP:0001640)2.08308648
129Basal ganglia calcification (HP:0002135)2.06967362
130Thoracic kyphosis (HP:0002942)2.06462255
131Spastic diplegia (HP:0001264)2.04963008
132Recurrent skin infections (HP:0001581)2.03998224
133Joint swelling (HP:0001386)2.02557887
134Menorrhagia (HP:0000132)2.02004467
135Thrombophlebitis (HP:0004418)2.01993848
136Supranuclear gaze palsy (HP:0000605)2.00787177
137Increased CSF protein (HP:0002922)1.98936542
138Lethargy (HP:0001254)1.97836606
139Spontaneous abortion (HP:0005268)1.97519218
140Urticaria (HP:0001025)1.96577142
141Conjunctival telangiectasia (HP:0000524)1.95931439
142Cardiovascular calcification (HP:0011915)1.95072457
143Polyneuropathy (HP:0001271)1.94864479
144Gastrointestinal infarctions (HP:0005244)1.94466624
145* Purpura (HP:0000979)1.93259529
146Polycythemia (HP:0001901)1.93068967
147Epistaxis (HP:0000421)1.92520735
148Axonal loss (HP:0003447)1.92122500
149Interstitial pulmonary disease (HP:0006530)1.91755838
150Sensorimotor neuropathy (HP:0007141)1.89308989
151Reticulocytosis (HP:0001923)1.88140419
152Abnormality of macrophages (HP:0004311)1.87675027
153Pulmonary embolism (HP:0002204)1.86842070
154Recurrent fungal infections (HP:0002841)1.86560587
155Vertebral compression fractures (HP:0002953)1.86278817
156Nonimmune hydrops fetalis (HP:0001790)1.85959011
157Increased mean platelet volume (HP:0011877)1.85840150
158Abnormal platelet volume (HP:0011876)1.85297386
159Vomiting (HP:0002013)1.84003761
160Malnutrition (HP:0004395)1.83891027
161Irritability (HP:0000737)1.82871107
162Periodontitis (HP:0000704)1.81916953
163Poor head control (HP:0002421)1.75944810
164Hemoptysis (HP:0002105)1.75604258
165Protuberant abdomen (HP:0001538)1.75435938
166J-shaped sella turcica (HP:0002680)1.74136726
167Memory impairment (HP:0002354)1.73630286
168Meningitis (HP:0001287)1.70544194
169Progressive visual loss (HP:0000529)1.70060249
170Recurrent viral infections (HP:0004429)1.67759926
171Beaking of vertebral bodies (HP:0004568)1.64128969
172Premature loss of primary teeth (HP:0006323)1.63448399
173* Metaphyseal irregularity (HP:0003025)1.60945351
174Vasculitis (HP:0002633)1.60776741
175Urinary incontinence (HP:0000020)1.60741863
176Acrocyanosis (HP:0001063)1.59284252
177Prostate neoplasm (HP:0100787)1.58463458
178Abnormality of the lumbar spine (HP:0100712)1.57862016
179Mucosal telangiectasiae (HP:0100579)1.57819865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.01621215
2ERN13.74596567
3BCKDK3.52508262
4FGFR43.26804836
5GRK72.97045837
6SIK12.77015557
7TRIB32.75413634
8TYK22.75114218
9ACVR1B2.61921073
10MST1R2.52743840
11DDR22.48289718
12TBK12.41855080
13BLK2.41818710
14MAP3K142.34804870
15TXK2.32689906
16MATK2.11539355
17TAOK22.09678661
18IRAK32.00461909
19GRK61.98861221
20IKBKE1.97895843
21JAK31.96858074
22ZAP701.91794554
23JAK11.90949698
24PRPF4B1.85320566
25CSK1.85035680
26STK101.82766091
27CAMKK21.79991877
28TAOK11.62509216
29PKN21.56596535
30CAMK1D1.51695957
31TGFBR21.49947510
32MAP3K101.48628468
33PIM21.45697464
34NME21.45136511
35CDC42BPA1.41525543
36JAK21.37466888
37TAOK31.37459315
38TESK21.34798364
39MOS1.34434041
40NEK91.32589101
41MAPK111.28233578
42ITK1.27658197
43IKBKB1.26009502
44KDR1.25436205
45LRRK21.22269505
46FGFR31.21339039
47SYK1.20366410
48ADRBK21.19536689
49IRAK41.19051422
50MAP3K131.13809773
51TESK11.08575454
52MAP3K11.07782131
53CSF1R1.06417146
54FLT31.05210355
55FES1.03666554
56ABL21.02244927
57EIF2AK11.02140667
58MST40.97268684
59PBK0.95812364
60KIT0.95587205
61MAP2K30.92017427
62LCK0.91805316
63BTK0.88724728
64LYN0.87952638
65RIPK10.86319838
66PAK40.85676528
67BMPR20.84727035
68PIM10.84453669
69CDK60.84045034
70CDK40.83761943
71PTK60.83230921
72RIPK40.82711244
73HCK0.82434090
74EPHB10.79561996
75NLK0.75984732
76MAP2K60.75619294
77PRKAA20.75337304
78ARAF0.75115238
79RPS6KA40.75098737
80BMX0.74305594
81CHUK0.73972724
82MAP3K50.73403154
83MAP3K30.72744785
84MARK30.70036976
85TEC0.68921158
86IRAK20.68748048
87RPS6KA20.66058690
88PRKCQ0.64782289
89MAP3K110.63372309
90LIMK10.62990929
91RPS6KC10.62935534
92RPS6KL10.62935534
93ERBB40.61778018
94CAMK1G0.60400790
95STK40.60006862
96TGFBR10.59246671
97PIK3CG0.57050644
98PDK10.56328320
99DAPK20.54668643
100CAMKK10.54234894
101SIK30.53804762
102EPHA30.53277371
103PRKCH0.53015736
104MAPK40.50692103
105PDPK10.50050312
106RPS6KA60.49210252
107TYRO30.48940038
108FRK0.48923243
109MET0.46327971
110MAPK120.44554052
111PDGFRA0.43925510
112IGF1R0.43083486
113ABL10.42777778
114PRKCD0.42619316
115EPHB20.42239652
116TTN0.41846348
117PDK20.41457383
118MAP3K80.40481551
119MAP3K70.37191245
120EGFR0.37110918
121TNK20.36744823
122PRKACG0.36693663
123INSR0.34890687
124STK30.34726460
125MAP2K10.34518957
126GSK3A0.34312435
127MAP2K20.33491716
128INSRR0.31496738
129FYN0.31398728
130ICK0.30596331
131PRKG20.30173350
132PDK40.29231120
133PDK30.29231120
134KSR20.27547547
135CDK90.27313581
136PRKAA10.27230303
137FGR0.26598122
138MAPKAPK20.25209316
139DAPK30.24993069
140MAPK70.24936980
141IRAK10.24740772
142MARK20.23537084

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.70250532
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.84219229
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.05370873
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98836622
5Nitrogen metabolism_Homo sapiens_hsa009102.79249180
6Staphylococcus aureus infection_Homo sapiens_hsa051502.75747867
7* Rheumatoid arthritis_Homo sapiens_hsa053232.75485672
8Complement and coagulation cascades_Homo sapiens_hsa046102.69027153
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62781910
10Asthma_Homo sapiens_hsa053102.62704434
11Arginine biosynthesis_Homo sapiens_hsa002202.53020329
12Fatty acid degradation_Homo sapiens_hsa000712.50891058
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43702402
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41196912
15Tryptophan metabolism_Homo sapiens_hsa003802.39671155
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37687643
17PPAR signaling pathway_Homo sapiens_hsa033202.32312297
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19239190
19Autoimmune thyroid disease_Homo sapiens_hsa053202.17341249
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12793175
21Propanoate metabolism_Homo sapiens_hsa006402.10147780
22Phagosome_Homo sapiens_hsa041452.09875893
23Caffeine metabolism_Homo sapiens_hsa002322.06404453
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97055967
25Peroxisome_Homo sapiens_hsa041461.96714478
26Fatty acid metabolism_Homo sapiens_hsa012121.91739750
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77617774
28beta-Alanine metabolism_Homo sapiens_hsa004101.77187466
29Collecting duct acid secretion_Homo sapiens_hsa049661.77064537
30Type I diabetes mellitus_Homo sapiens_hsa049401.73578216
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64967449
32Histidine metabolism_Homo sapiens_hsa003401.63665107
33Chemical carcinogenesis_Homo sapiens_hsa052041.63610744
34Butanoate metabolism_Homo sapiens_hsa006501.60622009
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.54869826
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54843160
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52479395
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52439112
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50490310
40Salmonella infection_Homo sapiens_hsa051321.43696341
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42791718
42Phenylalanine metabolism_Homo sapiens_hsa003601.42109180
43Toxoplasmosis_Homo sapiens_hsa051451.42106177
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.41088112
45TNF signaling pathway_Homo sapiens_hsa046681.40058867
46Folate biosynthesis_Homo sapiens_hsa007901.37818088
47Fat digestion and absorption_Homo sapiens_hsa049751.32522532
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32104531
49Viral myocarditis_Homo sapiens_hsa054161.32098911
50Retinol metabolism_Homo sapiens_hsa008301.30620242
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28593195
52Pyruvate metabolism_Homo sapiens_hsa006201.28161459
53Selenocompound metabolism_Homo sapiens_hsa004501.22240996
54ABC transporters_Homo sapiens_hsa020101.21417387
55Carbon metabolism_Homo sapiens_hsa012001.18721034
56Tyrosine metabolism_Homo sapiens_hsa003501.13846504
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10674798
58Bile secretion_Homo sapiens_hsa049761.10634918
59Starch and sucrose metabolism_Homo sapiens_hsa005001.09221464
60Glycerolipid metabolism_Homo sapiens_hsa005611.07973698
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07393581
62Vibrio cholerae infection_Homo sapiens_hsa051101.07305962
63Sulfur relay system_Homo sapiens_hsa041221.03247829
64Sphingolipid metabolism_Homo sapiens_hsa006001.03075697
65Vitamin B6 metabolism_Homo sapiens_hsa007501.02917767
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01447634
67Fatty acid biosynthesis_Homo sapiens_hsa000611.01102094
68Sulfur metabolism_Homo sapiens_hsa009201.01060199
69Pentose phosphate pathway_Homo sapiens_hsa000300.99371547
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98174092
71Fatty acid elongation_Homo sapiens_hsa000620.97823548
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91771076
73Biosynthesis of amino acids_Homo sapiens_hsa012300.90955270
74Primary immunodeficiency_Homo sapiens_hsa053400.89838482
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86796837
76Chemokine signaling pathway_Homo sapiens_hsa040620.86231493
77Mineral absorption_Homo sapiens_hsa049780.86040760
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85149370
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.84098942
80Graft-versus-host disease_Homo sapiens_hsa053320.83708961
81Herpes simplex infection_Homo sapiens_hsa051680.82348301
82Vitamin digestion and absorption_Homo sapiens_hsa049770.80153920
83Apoptosis_Homo sapiens_hsa042100.79294391
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78010806
85Shigellosis_Homo sapiens_hsa051310.75195707
86Steroid biosynthesis_Homo sapiens_hsa001000.75051067
87Glutathione metabolism_Homo sapiens_hsa004800.70650616
88Leishmaniasis_Homo sapiens_hsa051400.70230559
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70049890
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.69761560
91Bladder cancer_Homo sapiens_hsa052190.69702557
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.69394293
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.68314940
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64747861
95Amoebiasis_Homo sapiens_hsa051460.63871721
96Lysine degradation_Homo sapiens_hsa003100.63826765
97Acute myeloid leukemia_Homo sapiens_hsa052210.62778736
98Legionellosis_Homo sapiens_hsa051340.59884066
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.58644800
100Malaria_Homo sapiens_hsa051440.58022834
101Arginine and proline metabolism_Homo sapiens_hsa003300.57729643
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.57272725
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57265510
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57241127
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56292238
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.55830842
107Hepatitis B_Homo sapiens_hsa051610.55789968
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54455656
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.51494518
110Synaptic vesicle cycle_Homo sapiens_hsa047210.50751751
111Renin-angiotensin system_Homo sapiens_hsa046140.50678189
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50634526
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48761748
114One carbon pool by folate_Homo sapiens_hsa006700.48580372
115Insulin resistance_Homo sapiens_hsa049310.47909283
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47284230
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47036753
118Antigen processing and presentation_Homo sapiens_hsa046120.46951955
119Measles_Homo sapiens_hsa051620.44220992
120Epstein-Barr virus infection_Homo sapiens_hsa051690.43138145
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43107022
122Hematopoietic cell lineage_Homo sapiens_hsa046400.42504841
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42350064
124Pertussis_Homo sapiens_hsa051330.42325028
125* Osteoclast differentiation_Homo sapiens_hsa043800.39749885
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39322706
127VEGF signaling pathway_Homo sapiens_hsa043700.37701598
128* Lysosome_Homo sapiens_hsa041420.36033634
129Endocytosis_Homo sapiens_hsa041440.35997215
130Prion diseases_Homo sapiens_hsa050200.34052996
131B cell receptor signaling pathway_Homo sapiens_hsa046620.33008156
132HIF-1 signaling pathway_Homo sapiens_hsa040660.32886933
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.32720876
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32663214
135Fructose and mannose metabolism_Homo sapiens_hsa000510.32381118
136Allograft rejection_Homo sapiens_hsa053300.32120478
137Systemic lupus erythematosus_Homo sapiens_hsa053220.31864637
138Metabolic pathways_Homo sapiens_hsa011000.30997919
139Prolactin signaling pathway_Homo sapiens_hsa049170.30902510
140Tuberculosis_Homo sapiens_hsa051520.30046194
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.28480446
142Galactose metabolism_Homo sapiens_hsa000520.27487356
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26564415
144Hepatitis C_Homo sapiens_hsa051600.25622046
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24182460
146Platelet activation_Homo sapiens_hsa046110.24091784
147African trypanosomiasis_Homo sapiens_hsa051430.24031445
148Influenza A_Homo sapiens_hsa051640.23524853
149Ether lipid metabolism_Homo sapiens_hsa005650.23143460
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.22891723
151HTLV-I infection_Homo sapiens_hsa051660.21918018
152T cell receptor signaling pathway_Homo sapiens_hsa046600.21515334
153Notch signaling pathway_Homo sapiens_hsa043300.20043664
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15974402
155GnRH signaling pathway_Homo sapiens_hsa049120.14791525
156Renal cell carcinoma_Homo sapiens_hsa052110.14415968
157Type II diabetes mellitus_Homo sapiens_hsa049300.13627895
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.13124514
159Pancreatic cancer_Homo sapiens_hsa052120.11926864
160Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11287670
161Viral carcinogenesis_Homo sapiens_hsa052030.09458890

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