ACOT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.93572692
2central nervous system myelination (GO:0022010)4.93572692
3neuron cell-cell adhesion (GO:0007158)4.93134159
4synaptic vesicle exocytosis (GO:0016079)4.92374452
5vocalization behavior (GO:0071625)4.34474047
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.27772385
7neuronal action potential propagation (GO:0019227)4.25692935
8glutamate secretion (GO:0014047)4.15291908
9regulation of synaptic vesicle exocytosis (GO:2000300)4.12737446
10establishment of integrated proviral latency (GO:0075713)4.11957973
11synaptic vesicle maturation (GO:0016188)4.08863392
12fatty acid elongation (GO:0030497)4.07881307
13protein localization to synapse (GO:0035418)3.91484421
14negative regulation of neurotransmitter transport (GO:0051589)3.83614993
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.82797229
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82172921
17presynaptic membrane organization (GO:0097090)3.80124725
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79356259
19establishment of mitochondrion localization (GO:0051654)3.79246343
20ATP hydrolysis coupled proton transport (GO:0015991)3.74714233
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.74714233
22negative regulation of microtubule polymerization (GO:0031115)3.71018688
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69380757
24chaperone-mediated protein transport (GO:0072321)3.63663262
25presynaptic membrane assembly (GO:0097105)3.61518389
26neurotransmitter secretion (GO:0007269)3.57008150
27regulation of synaptic vesicle transport (GO:1902803)3.55134849
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50059008
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49637769
30neuron-neuron synaptic transmission (GO:0007270)3.46546898
31establishment of viral latency (GO:0019043)3.45457703
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.43563944
33neuron recognition (GO:0008038)3.41636532
34de novo protein folding (GO:0006458)3.39726351
35neurotransmitter uptake (GO:0001504)3.39724165
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39099602
37regulation of glutamate receptor signaling pathway (GO:1900449)3.38641471
38de novo posttranslational protein folding (GO:0051084)3.36764194
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35612103
40ATP synthesis coupled proton transport (GO:0015986)3.35612103
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32484238
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.31816165
43transferrin transport (GO:0033572)3.31344704
44protein neddylation (GO:0045116)3.30631748
45neurotransmitter transport (GO:0006836)3.30208839
46pyrimidine nucleobase catabolic process (GO:0006208)3.29130010
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22567683
48protein maturation by protein folding (GO:0022417)3.21715286
49synaptic transmission, glutamatergic (GO:0035249)3.20774400
50regulation of glutamate secretion (GO:0014048)3.17248383
51glutamate receptor signaling pathway (GO:0007215)3.16234152
52detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.15901056
53detection of temperature stimulus involved in sensory perception (GO:0050961)3.15901056
54adult walking behavior (GO:0007628)3.13613580
55regulation of neuronal synaptic plasticity (GO:0048168)3.11704018
56proteasome assembly (GO:0043248)3.07493583
57cullin deneddylation (GO:0010388)3.07464586
58locomotory exploration behavior (GO:0035641)3.07141361
59transmission of nerve impulse (GO:0019226)3.07083993
60gamma-aminobutyric acid transport (GO:0015812)3.06951126
61mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.04668470
62neuromuscular process controlling posture (GO:0050884)3.03517337
63regulation of dopamine metabolic process (GO:0042053)3.02929228
64regulation of catecholamine metabolic process (GO:0042069)3.02929228
65ferric iron transport (GO:0015682)3.02311923
66trivalent inorganic cation transport (GO:0072512)3.02311923
67regulation of neurotransmitter levels (GO:0001505)3.01731276
68respiratory electron transport chain (GO:0022904)3.01362893
69mitotic nuclear envelope reassembly (GO:0007084)3.00792323
70nuclear envelope reassembly (GO:0031468)3.00792323
71exploration behavior (GO:0035640)2.97318264
72positive regulation of synapse assembly (GO:0051965)2.97179883
73calcium ion-dependent exocytosis (GO:0017156)2.97050823
74electron transport chain (GO:0022900)2.96798707
75postsynaptic membrane organization (GO:0001941)2.96765142
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.96003097
77DNA damage response, detection of DNA damage (GO:0042769)2.95759967
78layer formation in cerebral cortex (GO:0021819)2.95709135
79establishment of protein localization to mitochondrial membrane (GO:0090151)2.95620284
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93339720
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93023873
82substantia nigra development (GO:0021762)2.92243328
83L-serine metabolic process (GO:0006563)2.91878010
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89712176
85peptidyl-arginine omega-N-methylation (GO:0035247)2.87916606
86regulation of neurotransmitter secretion (GO:0046928)2.87399466
87histone arginine methylation (GO:0034969)2.87129402
88protein deneddylation (GO:0000338)2.86533982
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85369958
90regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85116640
91regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85062351
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84887381
93dopamine biosynthetic process (GO:0042416)2.84279599
94long-term synaptic potentiation (GO:0060291)2.83922061
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83006965
96detection of temperature stimulus (GO:0016048)2.82297162
97regulation of vesicle fusion (GO:0031338)2.81885140
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81430029
99regulation of neurotransmitter transport (GO:0051588)2.81237634
100startle response (GO:0001964)2.80381091
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79935924
102negative regulation of ligase activity (GO:0051352)2.79935924
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79667578
104regulation of protein kinase A signaling (GO:0010738)2.79565503
105synaptic transmission, dopaminergic (GO:0001963)2.78970650
106axonal fasciculation (GO:0007413)2.78145857
107establishment of synaptic vesicle localization (GO:0097480)2.76631415
108synaptic vesicle transport (GO:0048489)2.76631415
109regulation of synapse structural plasticity (GO:0051823)2.76489368
110behavioral response to cocaine (GO:0048148)2.75743596
111protein localization to cilium (GO:0061512)2.75114852
112regulation of voltage-gated calcium channel activity (GO:1901385)2.74716940
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74382361
114nucleobase-containing small molecule interconversion (GO:0015949)2.73884219
115cell migration in hindbrain (GO:0021535)2.73728538
116proline transport (GO:0015824)2.73723989
117neurotransmitter-gated ion channel clustering (GO:0072578)2.73589481
118regulation of postsynaptic membrane potential (GO:0060078)2.73550963
119membrane hyperpolarization (GO:0060081)2.73267202
120regulation of synaptic transmission, GABAergic (GO:0032228)2.72000847
121calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71943891
122positive regulation of synapse maturation (GO:0090129)2.71431528
123DNA strand elongation involved in DNA replication (GO:0006271)2.71326213
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70924226
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.70822855
126synaptic vesicle endocytosis (GO:0048488)2.70302958
127regulation of mitochondrial translation (GO:0070129)2.70259258
128mating behavior (GO:0007617)2.69316469
129dopamine transport (GO:0015872)2.68936973
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67857821
131mitochondrion transport along microtubule (GO:0047497)2.67857821
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65059127
133regulation of cellular amino acid metabolic process (GO:0006521)2.62913447
134DNA strand elongation (GO:0022616)2.61979797
135mitotic metaphase plate congression (GO:0007080)2.59508170
136nucleobase catabolic process (GO:0046113)2.59301001
137neurofilament cytoskeleton organization (GO:0060052)2.52227160
138positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51887975
139positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.51032016
140mitotic sister chromatid segregation (GO:0000070)2.50017191
141protein complex localization (GO:0031503)2.49310694
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.47513473
143protein insertion into membrane (GO:0051205)2.47505308
144sodium ion export (GO:0071436)2.46898091
145telomere maintenance via semi-conservative replication (GO:0032201)2.46041380
146peptidyl-arginine methylation (GO:0018216)2.45550593
147peptidyl-arginine N-methylation (GO:0035246)2.45550593
148DNA unwinding involved in DNA replication (GO:0006268)2.43947931
149pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.43352132
150cellular potassium ion homeostasis (GO:0030007)2.40033914
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.38383293
152protein localization to kinetochore (GO:0034501)2.37658128
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.37654172
154termination of RNA polymerase III transcription (GO:0006386)2.37654172
155protein targeting to mitochondrion (GO:0006626)2.37518000
156tRNA aminoacylation for protein translation (GO:0006418)2.36597874
157cerebellar Purkinje cell layer development (GO:0021680)2.35427780
158sequestering of actin monomers (GO:0042989)2.35162307
159establishment of protein localization to mitochondrion (GO:0072655)2.35122638
160pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.33821848
161deoxyribonucleotide biosynthetic process (GO:0009263)2.33701167
162protein localization to chromosome, centromeric region (GO:0071459)2.32486067
163positive regulation of ligase activity (GO:0051351)2.32365002
164deoxyribose phosphate biosynthetic process (GO:0046385)2.31853549
1652-deoxyribonucleotide biosynthetic process (GO:0009265)2.31853549
166regulation of ligase activity (GO:0051340)2.31802206
167glycolytic process (GO:0006096)2.31558276
168DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.30982586
169positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.30369957
170regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.30369957
171heterochromatin organization (GO:0070828)2.29484061
172guanosine-containing compound biosynthetic process (GO:1901070)2.28503118
173amino acid activation (GO:0043038)2.28342875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63349450
2GBX2_23144817_ChIP-Seq_PC3_Human3.89138066
3E2F7_22180533_ChIP-Seq_HELA_Human3.75877109
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70314167
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33939973
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25798411
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.15203133
8TAF15_26573619_Chip-Seq_HEK293_Human3.04914258
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01533595
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.99670805
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83941232
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77986127
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74963093
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66811715
15REST_21632747_ChIP-Seq_MESCs_Mouse2.62879250
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51185299
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.48033569
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47989176
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45033704
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39042533
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37863531
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.35404661
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35339687
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33612496
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33236340
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32152882
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.29250358
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28102113
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28102113
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24629258
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.22737698
32XRN2_22483619_ChIP-Seq_HELA_Human2.22389157
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22057405
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18574026
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18122977
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.17348528
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15939767
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15421526
39SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13722639
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12255862
41ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12071967
42EZH2_27294783_Chip-Seq_ESCs_Mouse2.03236523
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98287887
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98185591
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.97538514
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97460300
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96358460
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.95459231
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.94693614
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.92752449
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91562461
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88936257
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88226143
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.88206976
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88036055
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.85877865
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83435060
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.81737743
59DCP1A_22483619_ChIP-Seq_HELA_Human1.81231735
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81050440
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80813306
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79708042
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71685581
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71530618
65DROSHA_22980978_ChIP-Seq_HELA_Human1.70019686
66GABP_19822575_ChIP-Seq_HepG2_Human1.69820703
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68282387
68VDR_22108803_ChIP-Seq_LS180_Human1.68051425
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.67111449
70P300_19829295_ChIP-Seq_ESCs_Human1.65581275
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63853018
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63538992
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58047178
74SMAD4_21799915_ChIP-Seq_A2780_Human1.56247348
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56185738
76* TTF2_22483619_ChIP-Seq_HELA_Human1.55661883
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53581318
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.53227389
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52131219
80AR_21572438_ChIP-Seq_LNCaP_Human1.51807235
81ER_23166858_ChIP-Seq_MCF-7_Human1.49003565
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46178356
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46055723
84* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45541768
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42672885
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41723760
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41257965
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.39297958
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38865845
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37276647
91RNF2_27304074_Chip-Seq_NSC_Mouse1.37259851
92IGF1R_20145208_ChIP-Seq_DFB_Human1.37183295
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36967206
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.36892993
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36291652
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35770795
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35072247
98FUS_26573619_Chip-Seq_HEK293_Human1.33303655
99* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33300187
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33287277
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31173646
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29820669
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28818977
104ZNF274_21170338_ChIP-Seq_K562_Hela1.28469618
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24614508
106AR_21909140_ChIP-Seq_LNCAP_Human1.24316643
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24097978
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24007357
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21748125
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.19877576
111AR_25329375_ChIP-Seq_VCAP_Human1.19258601
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19127087
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18968647
114* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17218694
115JUN_21703547_ChIP-Seq_K562_Human1.16774414
116* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16495669
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16331586
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15500024
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14716906
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14597704
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13845935
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13252073
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12401124
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11578173
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.11360924
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10933332
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.10811718
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10491199
129* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09346799
130PIAS1_25552417_ChIP-Seq_VCAP_Human1.08978552
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08117206
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07696504
133* FOXP1_21924763_ChIP-Seq_HESCs_Human1.07245252
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05933292
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05690074
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04524694
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04388155
138STAT3_23295773_ChIP-Seq_U87_Human1.04065492
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03980183
140ZNF263_19887448_ChIP-Seq_K562_Human1.02805785
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02800956
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01339399
143TCF4_23295773_ChIP-Seq_U87_Human1.01239380
144P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01196984
145E2F1_21310950_ChIP-Seq_MCF-7_Human1.01053745
146NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01052110
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00839348
148CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00821541
149* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00438954
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99723784
151KDM2B_26808549_Chip-Seq_REH_Human0.98617414
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.98170346
153* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97651642
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97497905
155MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96395327
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95751691
157RUNX2_22187159_ChIP-Seq_PCA_Human0.95693065
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.94827522
159* CTCF_27219007_Chip-Seq_Bcells_Human0.92684016
160* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92264772
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.92117365
162LXR_22292898_ChIP-Seq_THP-1_Human0.91886422
163DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91615949
164* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91541169
165SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90869950
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90326495
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89776616
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.89671102
169* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89360775
170PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87987767
171CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87905558
172* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87798275
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87321795
174* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85444260
175FOXP3_21729870_ChIP-Seq_TREG_Human0.85299317
176STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84093503
177FLI1_21867929_ChIP-Seq_TH2_Mouse0.83682148
178VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83468456
179CMYC_18555785_Chip-Seq_ESCs_Mouse0.82552050
180* SMAD3_21741376_ChIP-Seq_ESCs_Human0.81984850
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81561946
182SOX2_19829295_ChIP-Seq_ESCs_Human0.81388458
183NANOG_19829295_ChIP-Seq_ESCs_Human0.81388458
184IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80812696
185CBP_20019798_ChIP-Seq_JUKART_Human0.80812696
186HTT_18923047_ChIP-ChIP_STHdh_Human0.79503521
187SOX9_26525672_Chip-Seq_HEART_Mouse0.78872140
188SMAD4_21741376_ChIP-Seq_EPCs_Human0.78658794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.99356316
2MP0004859_abnormal_synaptic_plasticity4.37299660
3MP0004270_analgesia3.52420571
4MP0003635_abnormal_synaptic_transmissio3.41246537
5MP0001968_abnormal_touch/_nociception3.29517700
6MP0009046_muscle_twitch3.15015470
7MP0002064_seizures3.11558730
8MP0009745_abnormal_behavioral_response3.10234562
9MP0001529_abnormal_vocalization2.97659088
10MP0002736_abnormal_nociception_after2.97495644
11MP0002735_abnormal_chemical_nociception2.96060009
12MP0002272_abnormal_nervous_system2.89039713
13MP0002734_abnormal_mechanical_nocicepti2.75951950
14MP0002063_abnormal_learning/memory/cond2.75115221
15MP0002822_catalepsy2.70820470
16MP0005423_abnormal_somatic_nervous2.66667851
17MP0006276_abnormal_autonomic_nervous2.63746701
18MP0001905_abnormal_dopamine_level2.60471052
19MP0002572_abnormal_emotion/affect_behav2.60148037
20MP0002733_abnormal_thermal_nociception2.37634015
21MP0003693_abnormal_embryo_hatching2.36421545
22MP0001970_abnormal_pain_threshold2.34044533
23MP0001486_abnormal_startle_reflex2.31054108
24MP0001440_abnormal_grooming_behavior2.29376371
25MP0003123_paternal_imprinting2.24610166
26MP0004142_abnormal_muscle_tone2.17759491
27MP0003111_abnormal_nucleus_morphology2.16401497
28MP0003329_amyloid_beta_deposits2.13396976
29MP0000920_abnormal_myelination2.05929894
30MP0001501_abnormal_sleep_pattern2.04336535
31MP0002067_abnormal_sensory_capabilities2.01394859
32MP0005410_abnormal_fertilization1.99804655
33MP0008932_abnormal_embryonic_tissue1.97340625
34MP0004957_abnormal_blastocyst_morpholog1.85917584
35MP0000778_abnormal_nervous_system1.81878300
36MP0004924_abnormal_behavior1.81532790
37MP0005386_behavior/neurological_phenoty1.81532790
38MP0003121_genomic_imprinting1.76566319
39MP0002184_abnormal_innervation1.74747869
40MP0010094_abnormal_chromosome_stability1.63527446
41MP0008569_lethality_at_weaning1.57626051
42MP0003122_maternal_imprinting1.56609826
43MP0000955_abnormal_spinal_cord1.53898698
44MP0001986_abnormal_taste_sensitivity1.52598680
45MP0004811_abnormal_neuron_physiology1.52509504
46MP0004858_abnormal_nervous_system1.50674226
47MP0002557_abnormal_social/conspecific_i1.49199844
48MP0002066_abnormal_motor_capabilities/c1.45661439
49MP0000579_abnormal_nail_morphology1.45436849
50MP0002882_abnormal_neuron_morphology1.43999864
51MP0010030_abnormal_orbit_morphology1.43985413
52MP0004742_abnormal_vestibular_system1.41882482
53MP0003077_abnormal_cell_cycle1.41302227
54MP0008058_abnormal_DNA_repair1.39728014
55MP0000537_abnormal_urethra_morphology1.39313357
56MP0002229_neurodegeneration1.30792519
57MP0005646_abnormal_pituitary_gland1.29911668
58MP0001984_abnormal_olfaction1.29328159
59MP0003633_abnormal_nervous_system1.25753581
60MP0003631_nervous_system_phenotype1.25232149
61MP0006292_abnormal_olfactory_placode1.24700812
62MP0008007_abnormal_cellular_replicative1.23334464
63MP0003634_abnormal_glial_cell1.22533786
64MP0005645_abnormal_hypothalamus_physiol1.21956274
65MP0008789_abnormal_olfactory_epithelium1.20961106
66MP0003315_abnormal_perineum_morphology1.20655916
67MP0000751_myopathy1.20419156
68MP0003861_abnormal_nervous_system1.16794886
69MP0001188_hyperpigmentation1.15500014
70MP0003879_abnormal_hair_cell1.14075868
71MP0003787_abnormal_imprinting1.10461250
72MP0003632_abnormal_nervous_system1.07712676
73MP0004885_abnormal_endolymph1.05825978
74MP0009672_abnormal_birth_weight1.05452114
75MP0003718_maternal_effect1.03109026
76MP0002837_dystrophic_cardiac_calcinosis1.02686127
77MP0008872_abnormal_physiological_respon1.02091858
78MP0005409_darkened_coat_color1.01995542
79MP0000049_abnormal_middle_ear1.00766425
80MP0005171_absent_coat_pigmentation1.00073942
81MP0001502_abnormal_circadian_rhythm0.99624914
82MP0005257_abnormal_intraocular_pressure0.98976768
83MP0001963_abnormal_hearing_physiology0.98197303
84MP0002102_abnormal_ear_morphology0.97785691
85MP0000604_amyloidosis0.97287289
86MP0001730_embryonic_growth_arrest0.96317096
87MP0002752_abnormal_somatic_nervous0.95640485
88MP0002152_abnormal_brain_morphology0.95559696
89MP0003690_abnormal_glial_cell0.95232224
90MP0009379_abnormal_foot_pigmentation0.92774708
91MP0005551_abnormal_eye_electrophysiolog0.92735614
92MP0000566_synostosis0.91796024
93MP0009780_abnormal_chondrocyte_physiolo0.91210113
94MP0003941_abnormal_skin_development0.90507712
95MP0002234_abnormal_pharynx_morphology0.88634663
96MP0003119_abnormal_digestive_system0.86189145
97MP0000358_abnormal_cell_content/0.83371189
98MP0002938_white_spotting0.83339259
99MP0005501_abnormal_skin_physiology0.81816619
100MP0001664_abnormal_digestion0.81226872
101MP0005623_abnormal_meninges_morphology0.81119255
102MP0003385_abnormal_body_wall0.81051557
103MP0008260_abnormal_autophagy0.80348526
104MP0003786_premature_aging0.80236725
105MP0008874_decreased_physiological_sensi0.80048889
106MP0001485_abnormal_pinna_reflex0.79985031
107MP0002876_abnormal_thyroid_physiology0.79756735
108MP0008877_abnormal_DNA_methylation0.77905742
109MP0002877_abnormal_melanocyte_morpholog0.77558529
110MP0000350_abnormal_cell_proliferation0.77502307
111MP0002069_abnormal_eating/drinking_beha0.77329347
112MP0002081_perinatal_lethality0.76606433
113MP0004145_abnormal_muscle_electrophysio0.75354424
114MP0002751_abnormal_autonomic_nervous0.75189899
115MP0002085_abnormal_embryonic_tissue0.74761177
116MP0002653_abnormal_ependyma_morphology0.74297643
117MP0010386_abnormal_urinary_bladder0.73618005
118MP0002909_abnormal_adrenal_gland0.73274153
119MP0003698_abnormal_male_reproductive0.71788898
120MP0000534_abnormal_ureter_morphology0.71424150
121MP0002177_abnormal_outer_ear0.71226571
122MP0001348_abnormal_lacrimal_gland0.70377014
123MP0002080_prenatal_lethality0.69766417
124MP0002233_abnormal_nose_morphology0.68802717
125MP0004233_abnormal_muscle_weight0.68772807
126MP0000747_muscle_weakness0.68741099
127MP0006035_abnormal_mitochondrial_morpho0.68561290
128MP0001293_anophthalmia0.67732259
129MP0001346_abnormal_lacrimal_gland0.67611375
130MP0003937_abnormal_limbs/digits/tail_de0.67300619
131MP0002090_abnormal_vision0.67064585
132MP0004085_abnormal_heartbeat0.66312151
133MP0005535_abnormal_body_temperature0.65782250
134MP0002638_abnormal_pupillary_reflex0.65382286
135MP0004036_abnormal_muscle_relaxation0.64562601
136MP0001943_abnormal_respiration0.63931965
137MP0000013_abnormal_adipose_tissue0.62070173
138MP0003950_abnormal_plasma_membrane0.61472654
139MP0001177_atelectasis0.61005115
140MP0000631_abnormal_neuroendocrine_gland0.59616574
141MP0004484_altered_response_of0.58887015
142MP0004043_abnormal_pH_regulation0.55290218
143MP0005499_abnormal_olfactory_system0.54461016
144MP0005394_taste/olfaction_phenotype0.54461016
145MP0001299_abnormal_eye_distance/0.54334465
146MP0000026_abnormal_inner_ear0.53506669
147MP0006036_abnormal_mitochondrial_physio0.52890410

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.80170431
2Focal motor seizures (HP:0011153)5.57516398
3Atonic seizures (HP:0010819)4.17312105
4Pheochromocytoma (HP:0002666)4.11892143
5Focal seizures (HP:0007359)4.10176463
6Acute necrotizing encephalopathy (HP:0006965)3.98834889
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.89508589
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.89508589
9Limb dystonia (HP:0002451)3.88709248
10Epileptic encephalopathy (HP:0200134)3.87500783
11Neuroendocrine neoplasm (HP:0100634)3.86660137
12Abnormal mitochondria in muscle tissue (HP:0008316)3.64108835
13Abnormality of the corticospinal tract (HP:0002492)3.58283665
14Cortical dysplasia (HP:0002539)3.56750109
15Supranuclear gaze palsy (HP:0000605)3.56338725
16Neurofibrillary tangles (HP:0002185)3.55648788
17Progressive cerebellar ataxia (HP:0002073)3.42230756
18Visual hallucinations (HP:0002367)3.42185533
19Termporal pattern (HP:0011008)3.40852015
20Insidious onset (HP:0003587)3.40852015
21Progressive macrocephaly (HP:0004481)3.40128755
22Abnormality of glycolysis (HP:0004366)3.38020002
23Increased serum pyruvate (HP:0003542)3.38020002
24Ankle clonus (HP:0011448)3.24043188
25Mitochondrial inheritance (HP:0001427)3.23402248
26Cerebral inclusion bodies (HP:0100314)3.18204495
27Absence seizures (HP:0002121)3.12038329
28Febrile seizures (HP:0002373)3.11400253
29Upper limb muscle weakness (HP:0003484)3.11260158
30Acute encephalopathy (HP:0006846)3.07093216
31Dialeptic seizures (HP:0011146)3.02392992
32Abnormality of the labia minora (HP:0012880)3.00236040
33Leukodystrophy (HP:0002415)2.97542049
34Insomnia (HP:0100785)2.91537968
35Spastic gait (HP:0002064)2.90572691
36Dysmetria (HP:0001310)2.83534771
37Abnormal hair whorl (HP:0010721)2.79780413
38Hepatocellular necrosis (HP:0001404)2.79580291
39Hyperventilation (HP:0002883)2.77308752
40Action tremor (HP:0002345)2.76609443
41Generalized tonic-clonic seizures (HP:0002069)2.74184182
42Polyphagia (HP:0002591)2.68034115
43Sensory axonal neuropathy (HP:0003390)2.67277324
44Hand muscle atrophy (HP:0009130)2.64717861
45Progressive inability to walk (HP:0002505)2.64685758
46Retinal dysplasia (HP:0007973)2.64332366
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.64298264
48Absent/shortened dynein arms (HP:0200106)2.64298264
49Cerebral hypomyelination (HP:0006808)2.63475208
50Abnormal eating behavior (HP:0100738)2.62733070
51Increased CSF lactate (HP:0002490)2.61986669
52Peripheral hypomyelination (HP:0007182)2.60159411
53Urinary urgency (HP:0000012)2.50543652
54Hypothermia (HP:0002045)2.50503217
55Broad-based gait (HP:0002136)2.49912739
56Scanning speech (HP:0002168)2.48616636
57Gait imbalance (HP:0002141)2.45951328
58Anxiety (HP:0000739)2.43437080
59Poor suck (HP:0002033)2.42105141
60Truncal ataxia (HP:0002078)2.41141922
61Cerebral hemorrhage (HP:0001342)2.40938473
62Distal upper limb amyotrophy (HP:0007149)2.39362637
63Upper limb amyotrophy (HP:0009129)2.39362637
64Delusions (HP:0000746)2.38396504
65Abnormality of the lower motor neuron (HP:0002366)2.36292612
66Optic disc pallor (HP:0000543)2.35755121
67Impaired vibration sensation in the lower limbs (HP:0002166)2.33324494
68Medial flaring of the eyebrow (HP:0010747)2.29933671
69Amblyopia (HP:0000646)2.28249675
70Gaze-evoked nystagmus (HP:0000640)2.23187979
71Neoplasm of the peripheral nervous system (HP:0100007)2.22581381
72Urinary bladder sphincter dysfunction (HP:0002839)2.22574045
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21171443
74Failure to thrive in infancy (HP:0001531)2.20564795
75Akinesia (HP:0002304)2.19919394
76Autoamputation (HP:0001218)2.19434774
77Dysdiadochokinesis (HP:0002075)2.16757051
78Lower limb muscle weakness (HP:0007340)2.13704152
79Shoulder girdle muscle weakness (HP:0003547)2.11996263
80Lower limb amyotrophy (HP:0007210)2.11214363
81Degeneration of anterior horn cells (HP:0002398)2.11140473
82Abnormality of the anterior horn cell (HP:0006802)2.11140473
83Congenital primary aphakia (HP:0007707)2.08210217
84Mutism (HP:0002300)2.08102053
85Genital tract atresia (HP:0001827)2.06987489
86Vaginal atresia (HP:0000148)2.05553042
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.05318998
88Esotropia (HP:0000565)2.04734675
89Abnormality of binocular vision (HP:0011514)2.04102463
90Diplopia (HP:0000651)2.04102463
91Specific learning disability (HP:0001328)2.03929103
92Parakeratosis (HP:0001036)2.03632594
93Overriding aorta (HP:0002623)2.03305533
94Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02907297
95Hypoplasia of the brainstem (HP:0002365)2.02907297
96Generalized hypotonia (HP:0001290)2.02238831
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00721304
98Depression (HP:0000716)1.99961229
99Lissencephaly (HP:0001339)1.99399014
100Psychosis (HP:0000709)1.98352167
101Respiratory failure (HP:0002878)1.96907517
102Cholecystitis (HP:0001082)1.96701611
103Abnormal gallbladder physiology (HP:0012438)1.96701611
104Hyperacusis (HP:0010780)1.96608217
105Onion bulb formation (HP:0003383)1.95081474
106Selective tooth agenesis (HP:0001592)1.93552150
107Nephrogenic diabetes insipidus (HP:0009806)1.92343410
108Morphological abnormality of the pyramidal tract (HP:0002062)1.92152915
109Epileptiform EEG discharges (HP:0011182)1.91923364
110Poor eye contact (HP:0000817)1.91521715
111Emotional lability (HP:0000712)1.90849429
112Reticulocytopenia (HP:0001896)1.90683049
113Abnormal respiratory motile cilium morphology (HP:0005938)1.90329891
114Abnormal respiratory epithelium morphology (HP:0012253)1.90329891
115Inability to walk (HP:0002540)1.89531510
116X-linked dominant inheritance (HP:0001423)1.89381160
117Neuronal loss in central nervous system (HP:0002529)1.87337183
118CNS hypomyelination (HP:0003429)1.86495815
119Hypoventilation (HP:0002791)1.84897258
120Abnormal neuron morphology (HP:0012757)1.84327293
121Abnormality of the motor neurons (HP:0002450)1.84327293
122Focal dystonia (HP:0004373)1.82545709
123Sleep apnea (HP:0010535)1.82034004
124Rough bone trabeculation (HP:0100670)1.79113277
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77077232
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77077232
127Postnatal microcephaly (HP:0005484)1.75556438
128Spastic tetraplegia (HP:0002510)1.74895889
129Torticollis (HP:0000473)1.73169988
130EEG with generalized epileptiform discharges (HP:0011198)1.73123330
131Apathy (HP:0000741)1.73095540
132Hypsarrhythmia (HP:0002521)1.72120985
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70217049
134Craniofacial dystonia (HP:0012179)1.69511392
135Increased nuchal translucency (HP:0010880)1.69509484
136Hypokinesia (HP:0002375)1.69023378
137Heterochromia iridis (HP:0001100)1.68905004
138Cerebral edema (HP:0002181)1.68750918
139Spastic diplegia (HP:0001264)1.67797105
140Pointed chin (HP:0000307)1.67769589
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65677989
142Elfin facies (HP:0004428)1.65061032
143Cerebellar hypoplasia (HP:0001321)1.64890845
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64116778
145Long palpebral fissure (HP:0000637)1.63628004
146Diminished motivation (HP:0000745)1.63244193
147Hepatic necrosis (HP:0002605)1.62538561
148Abnormality of the hip-girdle musculature (HP:0001445)1.60434120
149Abnormality of the musculature of the pelvis (HP:0001469)1.60434120
150Unsteady gait (HP:0002317)1.59391289
151Distal lower limb amyotrophy (HP:0008944)1.57848526
152Pelvic girdle muscle weakness (HP:0003749)1.53493435
153High anterior hairline (HP:0009890)1.51743406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.51190110
2MAP3K123.36688238
3CASK3.34783909
4NTRK32.88710264
5STK392.77162228
6MAP2K72.55997910
7MAP3K42.54900909
8MARK12.52766793
9MAP3K92.41147803
10CDK192.39422544
11VRK22.38886526
12OXSR12.36535410
13PNCK2.31234737
14MAPKAPK52.25962926
15MINK12.25369646
16TRIM282.23909304
17NME22.12281460
18ARAF2.10849835
19GRK51.97185194
20EPHA41.93666815
21CDC71.88905061
22NEK11.85168333
23NTRK11.82925841
24LIMK11.76567199
25PLK21.75833620
26UHMK11.67122668
27NTRK21.53140355
28BRSK11.52593788
29MAP2K41.48579428
30BCR1.46147500
31SRPK11.43463836
32MAPK131.41701395
33TTK1.40760141
34PAK61.37440287
35EPHA21.35939484
36PLK31.34722042
37DAPK21.33224181
38NME11.32851404
39WNK41.30276852
40EPHB21.29368984
41CSNK1G31.28216850
42CAMK2B1.26550889
43CDK51.26044897
44KSR21.22085160
45PBK1.21465533
46CAMK2A1.20082312
47CSNK1G21.18409529
48PRPF4B1.17982395
49PIM21.17839579
50CDK141.15422351
51AURKA1.14345154
52SGK4941.14282629
53SGK2231.14282629
54GRK71.13708074
55TNIK1.13596384
56DAPK11.11247628
57CDK181.10933627
58PDK41.10019768
59PDK31.10019768
60LATS21.09593067
61PKN11.08823603
62TSSK61.08589632
63PAK41.08399610
64CDK151.07282254
65PLK11.05424068
66PTK2B1.04339399
67RIPK41.04210388
68FGR0.96430094
69PRKCG0.96410647
70ROCK20.96385386
71TESK20.95653968
72CDK11A0.94882013
73PHKG20.93490417
74PHKG10.93490417
75ADRBK20.92232417
76MAP3K110.91192378
77SMG10.90434549
78FES0.90112825
79CAMK2D0.89686396
80WEE10.86589328
81DYRK20.86249993
82WNK10.83905150
83BCKDK0.83896810
84CHEK20.83573300
85PTK20.80916698
86CAMK2G0.80864888
87PAK10.80698332
88PRKCE0.75706268
89BMPR1B0.72716659
90EIF2AK10.71789493
91EPHB10.69179594
92VRK10.69130593
93MUSK0.68668275
94PDK20.68420165
95CSNK1G10.67472082
96TESK10.67290425
97WNK30.67124349
98ABL20.66958859
99SIK20.66592577
100CSNK1A1L0.66114839
101MST1R0.66033340
102DAPK30.65239084
103ADRBK10.64196186
104PRKD30.64035530
105MST40.63466382
106CCNB10.62429271
107MYLK0.61985087
108AURKB0.61629399
109ICK0.58331908
110ILK0.58044579
111BRAF0.58043141
112PRKCI0.56826666
113PAK30.56182485
114CAMKK20.55145258
115ALK0.54997714
116SIK30.53227450
117STK160.52541286
118TYRO30.52002849
119MARK20.51388217
120MAP3K130.47367962
121ATR0.46886256
122KSR10.46852046
123MET0.46681951
124CAMKK10.45673758
125PLK40.44866701
126MAP3K80.44689372
127CAMK10.44200632
128RET0.43381694
129TNK20.42242909
130PINK10.40958413
131PDPK10.40878597
132CHEK10.40717553
133DYRK1A0.39693556
134ZAK0.39569894
135ERBB40.39555829
136BMPR20.39338174
137FYN0.39117003
138MAP3K20.39053004
139CDK70.39040984
140CSNK1E0.38875847
141PRKACA0.37798853
142PDK10.36076389
143AKT20.35950994
144LMTK20.35749962
145NEK60.35577070
146MAP3K10.32625634

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.73157944
2Oxidative phosphorylation_Homo sapiens_hsa001903.62381123
3Nicotine addiction_Homo sapiens_hsa050333.26135859
4Collecting duct acid secretion_Homo sapiens_hsa049663.15840160
5Parkinsons disease_Homo sapiens_hsa050123.00967695
6DNA replication_Homo sapiens_hsa030302.65636016
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.63585882
8Alzheimers disease_Homo sapiens_hsa050102.42418270
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40805401
10GABAergic synapse_Homo sapiens_hsa047272.36073770
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29467382
12Mismatch repair_Homo sapiens_hsa034302.17462498
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10832958
14Vibrio cholerae infection_Homo sapiens_hsa051102.08193428
15Morphine addiction_Homo sapiens_hsa050322.05292457
16Circadian entrainment_Homo sapiens_hsa047132.04419485
17Biosynthesis of amino acids_Homo sapiens_hsa012302.04075729
18Glutamatergic synapse_Homo sapiens_hsa047242.01317428
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96301418
20Amphetamine addiction_Homo sapiens_hsa050311.96127080
21Huntingtons disease_Homo sapiens_hsa050161.95332682
22Dopaminergic synapse_Homo sapiens_hsa047281.93429925
23Olfactory transduction_Homo sapiens_hsa047401.91920567
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90418111
25Serotonergic synapse_Homo sapiens_hsa047261.88935154
26Base excision repair_Homo sapiens_hsa034101.87986707
27Long-term potentiation_Homo sapiens_hsa047201.82479593
28RNA polymerase_Homo sapiens_hsa030201.75936589
29Cardiac muscle contraction_Homo sapiens_hsa042601.71193576
30Taste transduction_Homo sapiens_hsa047421.70501034
31Sulfur relay system_Homo sapiens_hsa041221.69289911
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67086776
33Long-term depression_Homo sapiens_hsa047301.60562125
34Cocaine addiction_Homo sapiens_hsa050301.59942128
35Salivary secretion_Homo sapiens_hsa049701.57772184
36Pyrimidine metabolism_Homo sapiens_hsa002401.53754765
37Steroid biosynthesis_Homo sapiens_hsa001001.53155837
38Cholinergic synapse_Homo sapiens_hsa047251.45893522
39Spliceosome_Homo sapiens_hsa030401.44422086
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41854011
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41485764
42Carbon metabolism_Homo sapiens_hsa012001.40501381
43Gastric acid secretion_Homo sapiens_hsa049711.33984732
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32833529
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32368402
46Renin secretion_Homo sapiens_hsa049241.30320618
47Cell cycle_Homo sapiens_hsa041101.29204502
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25930584
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25784686
50Insulin secretion_Homo sapiens_hsa049111.21694359
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18865693
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.13991589
53Ether lipid metabolism_Homo sapiens_hsa005651.13286614
54Rheumatoid arthritis_Homo sapiens_hsa053231.13064436
55Calcium signaling pathway_Homo sapiens_hsa040201.12986100
56Ribosome_Homo sapiens_hsa030101.12256838
57Gap junction_Homo sapiens_hsa045401.11697919
58RNA transport_Homo sapiens_hsa030131.11579679
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09327612
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08473701
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07548628
62Axon guidance_Homo sapiens_hsa043601.06956224
63* Fatty acid elongation_Homo sapiens_hsa000621.04253242
64Pentose phosphate pathway_Homo sapiens_hsa000301.04079432
65Folate biosynthesis_Homo sapiens_hsa007901.04034507
66Phagosome_Homo sapiens_hsa041451.01058984
67SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00908495
68Nucleotide excision repair_Homo sapiens_hsa034201.00846417
69Arginine and proline metabolism_Homo sapiens_hsa003300.99340142
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.97967513
71Oxytocin signaling pathway_Homo sapiens_hsa049210.96927239
72Proteasome_Homo sapiens_hsa030500.95689789
73Fructose and mannose metabolism_Homo sapiens_hsa000510.91779771
74Phototransduction_Homo sapiens_hsa047440.90926140
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89861169
76Pyruvate metabolism_Homo sapiens_hsa006200.89660359
77Galactose metabolism_Homo sapiens_hsa000520.88357487
78GnRH signaling pathway_Homo sapiens_hsa049120.85096436
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84387430
80Purine metabolism_Homo sapiens_hsa002300.83909214
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81511930
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77913192
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77541828
84Non-homologous end-joining_Homo sapiens_hsa034500.74624532
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74383895
86Hippo signaling pathway_Homo sapiens_hsa043900.74117254
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.70188359
88Homologous recombination_Homo sapiens_hsa034400.69552952
89mRNA surveillance pathway_Homo sapiens_hsa030150.68442395
90Fanconi anemia pathway_Homo sapiens_hsa034600.67476584
91cAMP signaling pathway_Homo sapiens_hsa040240.65895490
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65762523
93Vitamin B6 metabolism_Homo sapiens_hsa007500.65564748
94One carbon pool by folate_Homo sapiens_hsa006700.64339658
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63950116
96ErbB signaling pathway_Homo sapiens_hsa040120.63289176
97Estrogen signaling pathway_Homo sapiens_hsa049150.62543584
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.59705855
99Glutathione metabolism_Homo sapiens_hsa004800.59471718
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57951440
101Butanoate metabolism_Homo sapiens_hsa006500.57304936
102Oocyte meiosis_Homo sapiens_hsa041140.54729082
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54170221
104Alcoholism_Homo sapiens_hsa050340.52309733
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.52089935
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51713950
107Melanogenesis_Homo sapiens_hsa049160.51124703
108N-Glycan biosynthesis_Homo sapiens_hsa005100.51062236
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50000880
110Ras signaling pathway_Homo sapiens_hsa040140.48669108
111Endocytosis_Homo sapiens_hsa041440.48194062
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47983289
113* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46457732
114Pancreatic secretion_Homo sapiens_hsa049720.45955880
115Dorso-ventral axis formation_Homo sapiens_hsa043200.45604401
116Arginine biosynthesis_Homo sapiens_hsa002200.44976520
117Shigellosis_Homo sapiens_hsa051310.44393728
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44141321
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43060665
120Basal transcription factors_Homo sapiens_hsa030220.42558857
121Type I diabetes mellitus_Homo sapiens_hsa049400.42403755
122RNA degradation_Homo sapiens_hsa030180.41849939
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41405818
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41332617
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40506683
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40341354
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39941205
128MAPK signaling pathway_Homo sapiens_hsa040100.39755961
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.39581678
130Wnt signaling pathway_Homo sapiens_hsa043100.39149594
131Glioma_Homo sapiens_hsa052140.38464571
132Tight junction_Homo sapiens_hsa045300.37470028
133Renal cell carcinoma_Homo sapiens_hsa052110.37288177
134Phenylalanine metabolism_Homo sapiens_hsa003600.36531536
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.35339384
136Protein export_Homo sapiens_hsa030600.34745867
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33617977
138Thyroid hormone synthesis_Homo sapiens_hsa049180.32809097
139Sphingolipid metabolism_Homo sapiens_hsa006000.31863007
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28098877
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25648533
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25354785
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25077039
144Salmonella infection_Homo sapiens_hsa051320.24237499
145Sulfur metabolism_Homo sapiens_hsa009200.23699802
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23575334
147Dilated cardiomyopathy_Homo sapiens_hsa054140.22730634
148Ovarian steroidogenesis_Homo sapiens_hsa049130.21577979
149Metabolic pathways_Homo sapiens_hsa011000.20902314
150African trypanosomiasis_Homo sapiens_hsa051430.20129409
151Prion diseases_Homo sapiens_hsa050200.19965048
152Type II diabetes mellitus_Homo sapiens_hsa049300.18931532

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