ACOT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.41798010
2L-phenylalanine catabolic process (GO:0006559)7.41798010
3L-phenylalanine metabolic process (GO:0006558)7.12527754
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12527754
5aromatic amino acid family catabolic process (GO:0009074)6.63086308
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.57666017
7tryptophan catabolic process (GO:0006569)5.88346125
8indole-containing compound catabolic process (GO:0042436)5.88346125
9indolalkylamine catabolic process (GO:0046218)5.88346125
10kynurenine metabolic process (GO:0070189)5.78249130
11alpha-linolenic acid metabolic process (GO:0036109)5.72836515
12glyoxylate metabolic process (GO:0046487)5.67007340
13high-density lipoprotein particle remodeling (GO:0034375)5.66622468
14bile acid biosynthetic process (GO:0006699)5.59620634
15tryptophan metabolic process (GO:0006568)5.57985459
16urea cycle (GO:0000050)5.39890218
17urea metabolic process (GO:0019627)5.39890218
18cysteine metabolic process (GO:0006534)5.36432655
19negative regulation of fibrinolysis (GO:0051918)5.34192658
20sulfur amino acid catabolic process (GO:0000098)5.21038614
21serine family amino acid catabolic process (GO:0009071)5.14484399
22peptidyl-glutamic acid carboxylation (GO:0017187)5.13223721
23protein carboxylation (GO:0018214)5.13223721
24regulation of fibrinolysis (GO:0051917)5.07110536
25regulation of cholesterol esterification (GO:0010872)5.06698282
26bile acid metabolic process (GO:0008206)4.98625043
27nitrogen cycle metabolic process (GO:0071941)4.97325834
28reverse cholesterol transport (GO:0043691)4.92244133
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91062574
30lysine catabolic process (GO:0006554)4.88358633
31lysine metabolic process (GO:0006553)4.88358633
32negative regulation of sterol transport (GO:0032372)4.84763127
33negative regulation of cholesterol transport (GO:0032375)4.84763127
34protein-lipid complex remodeling (GO:0034368)4.84470907
35macromolecular complex remodeling (GO:0034367)4.84470907
36plasma lipoprotein particle remodeling (GO:0034369)4.84470907
37aromatic amino acid family metabolic process (GO:0009072)4.83158256
38cellular ketone body metabolic process (GO:0046950)4.83006399
39amino-acid betaine metabolic process (GO:0006577)4.82455246
40regulation of triglyceride catabolic process (GO:0010896)4.76104386
41drug catabolic process (GO:0042737)4.71461279
42homocysteine metabolic process (GO:0050667)4.69509852
43phospholipid efflux (GO:0033700)4.69432166
44tyrosine metabolic process (GO:0006570)4.68486354
45alpha-amino acid catabolic process (GO:1901606)4.62509430
46triglyceride homeostasis (GO:0070328)4.56096202
47acylglycerol homeostasis (GO:0055090)4.56096202
48regulation of protein activation cascade (GO:2000257)4.51226213
49plasma lipoprotein particle clearance (GO:0034381)4.46341835
50complement activation, alternative pathway (GO:0006957)4.46170275
51cellular glucuronidation (GO:0052695)4.28866652
52cholesterol efflux (GO:0033344)4.27994491
53cellular amino acid catabolic process (GO:0009063)4.27856763
54bile acid and bile salt transport (GO:0015721)4.27251949
55glutamate metabolic process (GO:0006536)4.26689344
56glycine metabolic process (GO:0006544)4.26543610
57indolalkylamine metabolic process (GO:0006586)4.21416631
58ketone body metabolic process (GO:1902224)4.17782176
59serine family amino acid metabolic process (GO:0009069)4.16561950
60regulation of complement activation (GO:0030449)4.12764321
61benzene-containing compound metabolic process (GO:0042537)4.12060406
62xenobiotic catabolic process (GO:0042178)4.11624264
63low-density lipoprotein particle remodeling (GO:0034374)4.10752939
64imidazole-containing compound metabolic process (GO:0052803)4.10133009
65cellular biogenic amine catabolic process (GO:0042402)4.10107773
66amine catabolic process (GO:0009310)4.10107773
67coenzyme catabolic process (GO:0009109)4.06188977
68plasma lipoprotein particle assembly (GO:0034377)4.05769788
69cellular modified amino acid catabolic process (GO:0042219)4.05061391
70serine family amino acid biosynthetic process (GO:0009070)3.97053121
71epoxygenase P450 pathway (GO:0019373)3.94239994
72dicarboxylic acid biosynthetic process (GO:0043650)3.93639310
73drug metabolic process (GO:0017144)3.93438118
74positive regulation of lipid catabolic process (GO:0050996)3.92843834
75arginine metabolic process (GO:0006525)3.92818567
76aldehyde catabolic process (GO:0046185)3.91587571
77ethanol oxidation (GO:0006069)3.90249973
78flavonoid metabolic process (GO:0009812)3.89582887
79negative regulation of lipase activity (GO:0060192)3.88283651
80exogenous drug catabolic process (GO:0042738)3.84855735
81uronic acid metabolic process (GO:0006063)3.83573351
82glucuronate metabolic process (GO:0019585)3.83573351
83piRNA metabolic process (GO:0034587)3.81799981
84* carboxylic acid catabolic process (GO:0046395)3.80875766
85* organic acid catabolic process (GO:0016054)3.80875766
86drug transmembrane transport (GO:0006855)3.79775329
87positive regulation of triglyceride lipase activity (GO:0061365)3.79076189
88positive regulation of lipoprotein lipase activity (GO:0051006)3.79076189
89fibrinolysis (GO:0042730)3.77345671
90regulation of bile acid biosynthetic process (GO:0070857)3.77225810
91cholesterol homeostasis (GO:0042632)3.77071222
92base-excision repair, AP site formation (GO:0006285)3.75678923
93sterol homeostasis (GO:0055092)3.71870280
94very-low-density lipoprotein particle assembly (GO:0034379)3.71812323
95carnitine metabolic process (GO:0009437)3.71004255
96phospholipid homeostasis (GO:0055091)3.70884560
97urate metabolic process (GO:0046415)3.70659836
98positive regulation of fatty acid beta-oxidation (GO:0032000)3.68664067
99plasma lipoprotein particle organization (GO:0071827)3.66030391
100monocarboxylic acid catabolic process (GO:0072329)3.65758961
101protein-lipid complex assembly (GO:0065005)3.64129925
102aspartate family amino acid catabolic process (GO:0009068)3.63129827
103acetyl-CoA metabolic process (GO:0006084)3.61732784
104regulation of cholesterol homeostasis (GO:2000188)3.61539377
105phenylpropanoid metabolic process (GO:0009698)3.60950488
106oxidative demethylation (GO:0070989)3.44495771
107omega-hydroxylase P450 pathway (GO:0097267)3.43338462
108branched-chain amino acid catabolic process (GO:0009083)3.40624144
109prostate gland growth (GO:0060736)3.37994183
110biotin metabolic process (GO:0006768)3.24423848
111branched-chain amino acid metabolic process (GO:0009081)3.24417499
112proteasome assembly (GO:0043248)3.18951552
113regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.11721948
114valine metabolic process (GO:0006573)3.10686793
115ubiquinone biosynthetic process (GO:0006744)3.06995613
116hepatocyte apoptotic process (GO:0097284)3.06267887
117positive regulation of cellular amine metabolic process (GO:0033240)3.06223506
118negative regulation of metanephros development (GO:0072217)3.05541955
119proline metabolic process (GO:0006560)3.03000434
120cofactor catabolic process (GO:0051187)3.02602574
121COPI coating of Golgi vesicle (GO:0048205)2.94962722
122Golgi transport vesicle coating (GO:0048200)2.94962722
123response to nitrosative stress (GO:0051409)2.91051685
124quinone biosynthetic process (GO:1901663)2.88222769
125mannosylation (GO:0097502)2.86051370
126quinone metabolic process (GO:1901661)2.84442640
127diol metabolic process (GO:0034311)2.81024863
128* short-chain fatty acid metabolic process (GO:0046459)2.80186928
129organic cation transport (GO:0015695)2.79711777
130nucleoside transmembrane transport (GO:1901642)2.73188199
131negative regulation of kidney development (GO:0090185)2.72239502
132glutathione derivative metabolic process (GO:1901685)2.70095570
133glutathione derivative biosynthetic process (GO:1901687)2.70095570
134ubiquinone metabolic process (GO:0006743)2.69108882
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.67858188
136galactose catabolic process (GO:0019388)2.67371181
137regulation of cellular amino acid metabolic process (GO:0006521)2.62343516
138folic acid metabolic process (GO:0046655)2.61770874
139sphingoid metabolic process (GO:0046519)2.60488621
140oxaloacetate metabolic process (GO:0006107)2.60430897
141regulation of lipoprotein particle clearance (GO:0010984)2.59848224
142S-adenosylmethionine metabolic process (GO:0046500)2.58098530
143regulation of cell proliferation involved in kidney development (GO:1901722)2.53736743
144L-methionine salvage (GO:0071267)2.53702063
145L-methionine biosynthetic process (GO:0071265)2.53702063
146amino acid salvage (GO:0043102)2.53702063
147heme transport (GO:0015886)2.53337817
148iron-sulfur cluster assembly (GO:0016226)2.48655463
149metallo-sulfur cluster assembly (GO:0031163)2.48655463
150daunorubicin metabolic process (GO:0044597)2.48017701
151polyketide metabolic process (GO:0030638)2.48017701
152doxorubicin metabolic process (GO:0044598)2.48017701
153glutathione biosynthetic process (GO:0006750)2.47739653
154steroid catabolic process (GO:0006706)2.47496486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.40696057
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.12235446
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.67939387
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50075865
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16477541
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.14593694
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.91047548
8ESR1_20079471_ChIP-ChIP_T-47D_Human4.73565597
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95495573
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92422910
11* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80446569
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26909004
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18134631
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00731257
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69045005
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.12510102
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10249987
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08363166
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06867121
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7240741
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.98449293
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90499652
23KDM5A_27292631_Chip-Seq_BREAST_Human1.67483494
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.67462022
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65658895
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.63417012
27CLOCK_20551151_ChIP-Seq_293T_Human1.62701208
28* ELF5_23300383_ChIP-Seq_T47D_Human1.60440945
29HTT_18923047_ChIP-ChIP_STHdh_Human1.51147139
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.44989558
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.40583788
32PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37577131
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37116271
34TFEB_21752829_ChIP-Seq_HELA_Human1.32350642
35GATA1_22025678_ChIP-Seq_K562_Human1.27526444
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27183792
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.27119717
38DCP1A_22483619_ChIP-Seq_HELA_Human1.26925997
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22472406
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20292652
41RACK7_27058665_Chip-Seq_MCF-7_Human1.19858853
42GABP_19822575_ChIP-Seq_HepG2_Human1.17838470
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15462608
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.14791026
45AHR_22903824_ChIP-Seq_MCF-7_Human1.14536694
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12615849
47BCOR_27268052_Chip-Seq_Bcells_Human1.11451443
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09762834
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09589147
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09011464
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07265289
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06727682
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06225808
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.05823186
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04326627
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03673222
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01706207
58E2F1_20622854_ChIP-Seq_HELA_Human1.01290994
59EOMES_21245162_ChIP-Seq_HESCs_Human1.00827365
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00387969
61* HOXB7_26014856_ChIP-Seq_BT474_Human1.00114908
62FOXP3_21729870_ChIP-Seq_TREG_Human0.99888917
63BCL6_27268052_Chip-Seq_Bcells_Human0.99873232
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98486331
65* RUNX1_27514584_Chip-Seq_MCF-7_Human0.96314519
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96224883
67GATA3_21878914_ChIP-Seq_MCF-7_Human0.95601464
68PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94440578
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94401444
70VDR_23849224_ChIP-Seq_CD4+_Human0.93250740
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92222330
72TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91477942
73GATA4_25053715_ChIP-Seq_YYC3_Human0.90207263
74SMC4_20622854_ChIP-Seq_HELA_Human0.89577802
75HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89474524
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89195070
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88775044
78P300_27268052_Chip-Seq_Bcells_Human0.88185256
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87166268
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86984993
81CTCF_26484167_Chip-Seq_Bcells_Mouse0.86950512
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86868512
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86588593
84ERA_21632823_ChIP-Seq_H3396_Human0.86476929
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86387095
86P68_20966046_ChIP-Seq_HELA_Human0.86134018
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.85152029
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85152029
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84933315
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83506189
91NANOG_20526341_ChIP-Seq_ESCs_Human0.83411009
92PHF8_20622854_ChIP-Seq_HELA_Human0.83013687
93SOX2_21211035_ChIP-Seq_LN229_Human0.82942220
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82522038
95CTCF_20526341_ChIP-Seq_ESCs_Human0.82103537
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81683087
97* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81468656
98RAC3_21632823_ChIP-Seq_H3396_Human0.81314844
99SA1_27219007_Chip-Seq_Bcells_Human0.81245048
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81128760
101NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80308769
102* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79663171
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78182601
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74529703
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73005825
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.71729158
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70882427
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.69709750
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69328949
110ZNF263_19887448_ChIP-Seq_K562_Human0.68168963
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67873001
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66876415
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66077956
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66077956
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65702868
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64786183
117* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64348593
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64167046
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60960597
120CEBPB_22108803_ChIP-Seq_LS180_Human0.60926631
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58508441
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58349679
123* ESR2_21235772_ChIP-Seq_MCF-7_Human0.58210243
124LXR_22292898_ChIP-Seq_THP-1_Human0.56866803
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.56357024
126STAT1_17558387_ChIP-Seq_HELA_Human0.55905444
127EGR1_19032775_ChIP-ChIP_M12_Human0.54409122
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.53825661
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53799737
130CBP_21632823_ChIP-Seq_H3396_Human0.53463172
131AR_20517297_ChIP-Seq_VCAP_Human0.52605165
132MYC_19915707_ChIP-ChIP_AK7_Human0.52454066
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.52245800
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.52121814
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.51718488
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51504362
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48447853
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48039084
139P53_21459846_ChIP-Seq_SAOS-2_Human0.46945731
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46762492
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46387881
142TAF15_26573619_Chip-Seq_HEK293_Human0.45985660
143BCAT_22108803_ChIP-Seq_LS180_Human0.45283231
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45189427
145GATA2_19941826_ChIP-Seq_K562_Human0.44609554
146GATA1_19941826_ChIP-Seq_K562_Human0.44584379
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.43645798
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.43146630
149GATA6_25053715_ChIP-Seq_YYC3_Human0.42914741
150CDX2_22108803_ChIP-Seq_LS180_Human0.42546093
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42338469
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42212560
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.42212253
154TAF2_19829295_ChIP-Seq_ESCs_Human0.41235436
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41131883
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39823997
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39362752
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.38960545
159SOX2_20726797_ChIP-Seq_SW620_Human0.38566372
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.37136722
161LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37087972
162NCOR_22424771_ChIP-Seq_293T_Human0.36454722
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36425868
164STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35747612
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.35449511
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.34808237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41440677
2MP0005360_urolithiasis7.70415593
3MP0005085_abnormal_gallbladder_physiolo6.22031122
4MP0005365_abnormal_bile_salt6.06001916
5MP0008875_abnormal_xenobiotic_pharmacok5.45263246
6MP0003806_abnormal_nucleotide_metabolis3.97602602
7MP0003252_abnormal_bile_duct3.83944504
8MP0010329_abnormal_lipoprotein_level3.55445278
9MP0009840_abnormal_foam_cell3.25890314
10MP0005083_abnormal_biliary_tract3.01880343
11MP0003195_calcinosis3.01255543
12MP0005332_abnormal_amino_acid2.97948648
13MP0001666_abnormal_nutrient_absorption2.55615022
14MP0004019_abnormal_vitamin_homeostasis2.43581056
15MP0005379_endocrine/exocrine_gland_phen2.36576371
16MP0001919_abnormal_reproductive_system2.34242330
17MP0003191_abnormal_cellular_cholesterol2.17650389
18MP0000609_abnormal_liver_physiology2.11440138
19MP0002118_abnormal_lipid_homeostasis2.11403598
20MP0002138_abnormal_hepatobiliary_system2.03752642
21MP0004264_abnormal_extraembryonic_tissu1.98701873
22MP0005075_abnormal_melanosome_morpholog1.94509287
23MP0000427_abnormal_hair_cycle1.83652345
24MP0005646_abnormal_pituitary_gland1.82756331
25MP0005451_abnormal_body_composition1.80782717
26MP0005319_abnormal_enzyme/_coenzyme1.79525177
27MP0003868_abnormal_feces_composition1.79211358
28MP0001881_abnormal_mammary_gland1.77205702
29MP0005377_hearing/vestibular/ear_phenot1.72489292
30MP0003878_abnormal_ear_physiology1.72489292
31MP0001764_abnormal_homeostasis1.64150738
32MP0005584_abnormal_enzyme/coenzyme_acti1.59446116
33MP0005389_reproductive_system_phenotype1.58925839
34MP0008995_early_reproductive_senescence1.56613795
35MP0001346_abnormal_lacrimal_gland1.54122433
36MP0002098_abnormal_vibrissa_morphology1.53966181
37MP0001727_abnormal_embryo_implantation1.53798037
38MP0003786_premature_aging1.52822498
39MP0009697_abnormal_copulation1.52306746
40MP0000627_abnormal_mammary_gland1.44563774
41MP0009643_abnormal_urine_homeostasis1.42375632
42MP0001873_stomach_inflammation1.37687826
43MP0008877_abnormal_DNA_methylation1.37613750
44MP0004233_abnormal_muscle_weight1.31685410
45MP0003011_delayed_dark_adaptation1.30397937
46MP0003183_abnormal_peptide_metabolism1.28967836
47MP0010386_abnormal_urinary_bladder1.26318783
48MP0003186_abnormal_redox_activity1.24292218
49MP0009780_abnormal_chondrocyte_physiolo1.22127867
50MP0000015_abnormal_ear_pigmentation1.17639339
51MP0002160_abnormal_reproductive_system1.14331989
52MP0003656_abnormal_erythrocyte_physiolo1.13019071
53MP0000598_abnormal_liver_morphology1.12778698
54MP0005410_abnormal_fertilization1.12594259
55MP0004381_abnormal_hair_follicle1.12083352
56MP0000604_amyloidosis1.11904825
57MP0005636_abnormal_mineral_homeostasis1.07773522
58MP0003936_abnormal_reproductive_system1.07768986
59MP0009764_decreased_sensitivity_to1.04603425
60MP0005645_abnormal_hypothalamus_physiol1.03365702
61MP0010678_abnormal_skin_adnexa1.02987072
62MP0005647_abnormal_sex_gland0.98679644
63MP0009763_increased_sensitivity_to0.95553539
64MP0002909_abnormal_adrenal_gland0.95356764
65MP0005367_renal/urinary_system_phenotyp0.94726172
66MP0000516_abnormal_urinary_system0.94726172
67MP0003705_abnormal_hypodermis_morpholog0.94649467
68MP0002876_abnormal_thyroid_physiology0.91523773
69MP0006036_abnormal_mitochondrial_physio0.89443562
70MP0009642_abnormal_blood_homeostasis0.88621002
71MP0005670_abnormal_white_adipose0.88528193
72MP0002254_reproductive_system_inflammat0.87484292
73MP0000383_abnormal_hair_follicle0.86998484
74MP0000003_abnormal_adipose_tissue0.86030158
75MP0003123_paternal_imprinting0.85983170
76MP0005084_abnormal_gallbladder_morpholo0.84205962
77MP0001944_abnormal_pancreas_morphology0.84162855
78MP0008469_abnormal_protein_level0.82793402
79MP0010368_abnormal_lymphatic_system0.82156911
80MP0002078_abnormal_glucose_homeostasis0.82077788
81MP0002877_abnormal_melanocyte_morpholog0.80458850
82MP0003763_abnormal_thymus_physiology0.80399784
83MP0001756_abnormal_urination0.79695850
84MP0002163_abnormal_gland_morphology0.78013888
85MP0009765_abnormal_xenobiotic_induced0.77518958
86MP0002971_abnormal_brown_adipose0.76191342
87MP0005376_homeostasis/metabolism_phenot0.76049022
88MP0005408_hypopigmentation0.75828685
89MP0000367_abnormal_coat/_hair0.75533878
90MP0004130_abnormal_muscle_cell0.74598092
91MP0003315_abnormal_perineum_morphology0.73978926
92MP0002166_altered_tumor_susceptibility0.73752479
93MP0001661_extended_life_span0.73186939
94MP0003172_abnormal_lysosome_physiology0.72649580
95MP0009333_abnormal_splenocyte_physiolog0.72412729
96MP0003329_amyloid_beta_deposits0.71308839
97MP0005334_abnormal_fat_pad0.70928517
98MP0005535_abnormal_body_temperature0.70308374
99MP0005671_abnormal_response_to0.68847703
100MP0002693_abnormal_pancreas_physiology0.67091190
101MP0008058_abnormal_DNA_repair0.67076021
102MP0001929_abnormal_gametogenesis0.66952294
103MP0000377_abnormal_hair_follicle0.66610604
104MP0005220_abnormal_exocrine_pancreas0.65962177
105MP0003690_abnormal_glial_cell0.64992899
106MP0002136_abnormal_kidney_physiology0.63433392
107MP0005266_abnormal_metabolism0.62038165
108MP0006035_abnormal_mitochondrial_morpho0.60441381
109MP0005448_abnormal_energy_balance0.60351769
110MP0009053_abnormal_anal_canal0.58499972
111MP0000639_abnormal_adrenal_gland0.54647320
112MP0004043_abnormal_pH_regulation0.54563095
113MP0005395_other_phenotype0.52915952
114MP0008874_decreased_physiological_sensi0.50649884
115MP0003638_abnormal_response/metabolism_0.49702996
116MP0002928_abnormal_bile_duct0.48812823
117MP0005666_abnormal_adipose_tissue0.48719686
118MP0005464_abnormal_platelet_physiology0.48680318
119MP0002822_catalepsy0.46736978
120MP0003718_maternal_effect0.46297197
121MP0003953_abnormal_hormone_level0.45166867
122MP0008872_abnormal_physiological_respon0.44254603
123MP0008873_increased_physiological_sensi0.43675181
124MP0002837_dystrophic_cardiac_calcinosis0.43252627
125MP0005248_abnormal_Harderian_gland0.42554594
126MP0002168_other_aberrant_phenotype0.40729875
127MP0004782_abnormal_surfactant_physiolog0.40539392
128MP0001765_abnormal_ion_homeostasis0.40353434
129MP0000230_abnormal_systemic_arterial0.40186811
130MP0003724_increased_susceptibility_to0.37816005
131MP0009115_abnormal_fat_cell0.37145225
132MP0003075_altered_response_to0.35772553
133MP0009672_abnormal_birth_weight0.35113759
134MP0003436_decreased_susceptibility_to0.34483935
135MP0000249_abnormal_blood_vessel0.30569494
136MP0002970_abnormal_white_adipose0.30328927
137MP0010234_abnormal_vibrissa_follicle0.28951555
138MP0005167_abnormal_blood-brain_barrier0.28006341
139MP0001243_abnormal_dermal_layer0.27858805
140MP0004883_abnormal_blood_vessel0.26655852
141MP0002796_impaired_skin_barrier0.26270953
142MP0005166_decreased_susceptibility_to0.26119898
143MP0005058_abnormal_lysosome_morphology0.25721899
144MP0002090_abnormal_vision0.25445628
145MP0001845_abnormal_inflammatory_respons0.25347661
146MP0002135_abnormal_kidney_morphology0.24905980
147MP0000538_abnormal_urinary_bladder0.24328771
148MP0006082_CNS_inflammation0.24210036
149MP0001853_heart_inflammation0.24160882

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27313860
2Deep venous thrombosis (HP:0002625)7.14551286
3Intrahepatic cholestasis (HP:0001406)6.73128259
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.42336315
5Hypobetalipoproteinemia (HP:0003563)6.38144828
6Xanthomatosis (HP:0000991)6.27855108
7Prolonged partial thromboplastin time (HP:0003645)6.13537861
8Hyperlipoproteinemia (HP:0010980)5.51616632
9Hypolipoproteinemia (HP:0010981)4.73160630
10Hyperammonemia (HP:0001987)4.72125293
11Joint hemorrhage (HP:0005261)4.63496250
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.53800063
13Ketosis (HP:0001946)4.52874727
14Hyperglycinemia (HP:0002154)4.49222650
15Epidermoid cyst (HP:0200040)4.40346155
16Hyperglycinuria (HP:0003108)4.39675764
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33904451
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.33363229
19Abnormality of glycine metabolism (HP:0010895)4.26712840
20Abnormality of serine family amino acid metabolism (HP:0010894)4.26712840
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.24762585
22Abnormality of methionine metabolism (HP:0010901)4.21640766
23Hypoalphalipoproteinemia (HP:0003233)4.11664803
24Abnormality of the common coagulation pathway (HP:0010990)4.09245457
25Complement deficiency (HP:0004431)4.03513867
26Hypoglycemic coma (HP:0001325)3.97533361
27Fat malabsorption (HP:0002630)3.83250561
28Abnormality of pyrimidine metabolism (HP:0004353)3.79283020
29Hypercholesterolemia (HP:0003124)3.72608205
30Abnormality of glycolipid metabolism (HP:0010969)3.67232214
31Abnormality of liposaccharide metabolism (HP:0010968)3.67232214
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.67232214
33Abnormality of fatty-acid metabolism (HP:0004359)3.60639146
34Conjugated hyperbilirubinemia (HP:0002908)3.58826961
35Hypokinesia (HP:0002375)3.44405146
36Ketoacidosis (HP:0001993)3.42281440
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42174732
38Abnormality of the intrinsic pathway (HP:0010989)3.41976126
39Hyperbilirubinemia (HP:0002904)3.36217085
40Vacuolated lymphocytes (HP:0001922)3.31846489
41Abnormality of nucleobase metabolism (HP:0010932)3.31362285
42Delayed CNS myelination (HP:0002188)3.30987148
43Abnormality of serum amino acid levels (HP:0003112)3.13830740
44Abnormality of purine metabolism (HP:0004352)3.07401918
45Oligomenorrhea (HP:0000876)3.00277030
46Metabolic acidosis (HP:0001942)2.98907974
47Reduced antithrombin III activity (HP:0001976)2.98429967
48Hepatocellular carcinoma (HP:0001402)2.94024927
49Gout (HP:0001997)2.93199642
50Abnormality of complement system (HP:0005339)2.90876391
51Vascular calcification (HP:0004934)2.85074134
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84340565
53Dicarboxylic aciduria (HP:0003215)2.84340565
54Prolonged neonatal jaundice (HP:0006579)2.77832882
55Steatorrhea (HP:0002570)2.77507241
56Lethargy (HP:0001254)2.75533657
57Concave nail (HP:0001598)2.75176596
58Tongue fasciculations (HP:0001308)2.74526972
59Spontaneous abortion (HP:0005268)2.69342327
60Myocardial infarction (HP:0001658)2.68748758
61Skin nodule (HP:0200036)2.66033506
62Testicular atrophy (HP:0000029)2.61127263
63Malnutrition (HP:0004395)2.55813365
64Abnormal tarsal ossification (HP:0008369)2.53742891
65Cardiovascular calcification (HP:0011915)2.52713690
66Hypoglycemic seizures (HP:0002173)2.50854966
67Hypochromic microcytic anemia (HP:0004840)2.50355116
68Acanthocytosis (HP:0001927)2.50001970
69Spastic diplegia (HP:0001264)2.49503188
70Cerebral edema (HP:0002181)2.45931716
71Irritability (HP:0000737)2.43724693
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43700157
73Abnormality of polysaccharide metabolism (HP:0011012)2.43700157
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43700157
75Generalized aminoaciduria (HP:0002909)2.41518130
76Glomerulonephritis (HP:0000099)2.37032868
77Mitral stenosis (HP:0001718)2.32985116
78Abnormal gallbladder morphology (HP:0012437)2.31902744
79Abnormality of proline metabolism (HP:0010907)2.28533496
80Hydroxyprolinuria (HP:0003080)2.28533496
81Alkalosis (HP:0001948)2.28357736
82Proximal tubulopathy (HP:0000114)2.26993535
83Cholelithiasis (HP:0001081)2.26877370
84Cholecystitis (HP:0001082)2.25706938
85Abnormal gallbladder physiology (HP:0012438)2.25706938
86Neonatal onset (HP:0003623)2.24517022
87Vomiting (HP:0002013)2.24363802
88Late onset (HP:0003584)2.24227063
89Acute encephalopathy (HP:0006846)2.23535451
90Retinal atrophy (HP:0001105)2.22637478
91Abnormality of the renal cortex (HP:0011035)2.22436736
92Enlarged kidneys (HP:0000105)2.21681815
93Dry hair (HP:0011359)2.21144784
94Pancreatitis (HP:0001733)2.20159288
95Amelogenesis imperfecta (HP:0000705)2.20063008
96Prostate neoplasm (HP:0100787)2.19708714
97Brushfield spots (HP:0001088)2.18151842
98Muscle fibrillation (HP:0010546)2.17179196
99Abnormal mitochondria in muscle tissue (HP:0008316)2.17153536
100Menorrhagia (HP:0000132)2.15668981
101Hepatic necrosis (HP:0002605)2.13555117
102Rickets (HP:0002748)2.13335959
103Systemic lupus erythematosus (HP:0002725)2.12929067
104Increased purine levels (HP:0004368)2.12774868
105Hyperuricemia (HP:0002149)2.12774868
106Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12129828
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12129828
108Esophageal varix (HP:0002040)2.10819268
109Glycosuria (HP:0003076)2.10816821
110Abnormality of urine glucose concentration (HP:0011016)2.10816821
111Mucopolysacchariduria (HP:0008155)2.10801665
112Urinary glycosaminoglycan excretion (HP:0003541)2.10801665
113Amyloidosis (HP:0011034)2.09216622
114Sensorimotor neuropathy (HP:0007141)2.09025915
115Nausea (HP:0002018)2.08621702
116Beaking of vertebral bodies (HP:0004568)2.08251039
117Dysostosis multiplex (HP:0000943)2.07018481
118Hyperinsulinemic hypoglycemia (HP:0000825)2.05620605
119Type I transferrin isoform profile (HP:0003642)2.03540474
120Increased CSF lactate (HP:0002490)2.03374758
121Testicular neoplasm (HP:0010788)2.02680314
122Congenital ichthyosiform erythroderma (HP:0007431)2.01342609
123Abnormality of the anterior horn cell (HP:0006802)2.00866353
124Degeneration of anterior horn cells (HP:0002398)2.00866353
125Poikilocytosis (HP:0004447)2.00071827
126Renal cortical cysts (HP:0000803)1.99768221
127Ependymoma (HP:0002888)1.99613101
128Gingival bleeding (HP:0000225)1.98684536
129Opisthotonus (HP:0002179)1.98198106
130Hypophosphatemic rickets (HP:0004912)1.96245173
131Thrombophlebitis (HP:0004418)1.95540613
132Mitochondrial inheritance (HP:0001427)1.92586145
133Hemorrhage of the eye (HP:0011885)1.91710112
134Increased muscle lipid content (HP:0009058)1.91524199
135Hyperphosphaturia (HP:0003109)1.90639251
136Spastic paraparesis (HP:0002313)1.90337480
137Flat capital femoral epiphysis (HP:0003370)1.89952194
138Albinism (HP:0001022)1.89174406
139Abnormality of the gallbladder (HP:0005264)1.88195009
140Diminished movement (HP:0002374)1.87531655
141Hypergonadotropic hypogonadism (HP:0000815)1.86811996
142CNS demyelination (HP:0007305)1.86372705
143Abnormal cartilage morphology (HP:0002763)1.86301876
144Gonadal dysgenesis (HP:0000133)1.86119792
145Abnormal hair laboratory examination (HP:0003328)1.85593753
146Cerebral palsy (HP:0100021)1.84977658
147Pili torti (HP:0003777)1.84649069
148Increased serum lactate (HP:0002151)1.84528581
149Acute necrotizing encephalopathy (HP:0006965)1.84064282
150Abnormal urine phosphate concentration (HP:0012599)1.84013597
151Abnormality of vitamin metabolism (HP:0100508)1.84005964
152Increased intramyocellular lipid droplets (HP:0012240)1.83278408
153Confusion (HP:0001289)1.82660046
154Abnormal pupillary function (HP:0007686)1.81745189
155Abnormal enzyme/coenzyme activity (HP:0012379)1.81442270
156Status epilepticus (HP:0002133)1.81288516
157Insulin-resistant diabetes mellitus (HP:0000831)1.80826376
158Osteomalacia (HP:0002749)1.80376588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.66699689
2TESK25.97258738
3SIK14.62884901
4FGFR44.13524043
5MAPKAPK33.90464411
6ERN13.61423480
7VRK23.48904441
8MAP3K123.21600307
9INSRR3.01815354
10EPHA23.01704477
11TAOK32.71466560
12SCYL22.70009803
13PKN22.61716400
14MAP2K42.31758599
15MUSK2.31334916
16TESK12.28606254
17RPS6KB22.26506652
18MST1R2.26502296
19FLT32.14042562
20MAP2K22.12297149
21CAMKK21.98846431
22MST41.97077965
23NME21.95304561
24ERBB41.92001556
25EIF2AK31.87182348
26PIK3CG1.85432165
27FRK1.77832953
28DAPK21.70099603
29LATS11.67978013
30TRIB31.67200062
31PBK1.60751881
32PRKCI1.58890579
33DAPK11.54834234
34MAPK111.51878684
35TYK21.49006649
36ABL21.47302610
37PTK61.45259969
38NUAK11.41662486
39PINK11.35152257
40NEK61.33633177
41PRKAA21.32401700
42ZAK1.30641003
43EIF2AK11.29395948
44STK38L1.29382850
45KDR1.28083048
46LIMK11.28069023
47FGFR21.27337565
48MYLK1.24802689
49GRK61.23768161
50MAP3K71.18844054
51NEK91.18820682
52PAK41.13419040
53WNK31.09505803
54JAK21.07908555
55TLK11.01063856
56IKBKB1.00867738
57MAPK40.99155184
58EPHA40.98754919
59MAP2K30.96111258
60TAF10.95040432
61PRKCZ0.93004713
62STK160.92355782
63CSNK1G30.91099353
64JAK10.88466891
65MAP3K110.88213100
66TBK10.87645114
67NME10.86591190
68DYRK1B0.85996189
69MAP3K30.85520071
70WNK40.84802660
71CSK0.84626875
72TIE10.84573785
73MAP3K140.81968897
74OXSR10.81926106
75VRK10.81572656
76CAMK2D0.80066377
77CDK60.78972354
78PRKACG0.78662984
79CAMKK10.77778687
80MAP3K100.76965644
81TRIM280.75489323
82KSR20.75408375
83TXK0.74949982
84RIPK10.74330992
85PRKAA10.74312878
86MET0.74210563
87CCNB10.74137310
88MAPK120.73671108
89CAMK1D0.73142566
90ERBB20.73047144
91SGK30.72526720
92EPHB10.72417104
93GSK3A0.71066448
94CDK90.70024731
95EPHA30.67609021
96PDK40.66397166
97PDK30.66397166
98STK30.63499157
99BMPR20.63351416
100SGK4940.62895025
101SGK2230.62895025
102MAP4K10.62260045
103CHUK0.62137367
104MAP2K60.62057194
105ADRBK20.61436488
106PDPK10.60647498
107SGK20.60523778
108SMG10.60263445
109MAPK150.59323022
110CSNK1A1L0.58202333
111TAOK20.56848330
112PTK20.56701901
113TGFBR20.56052465
114NEK10.54044623
115CAMK2G0.53081237
116GRK10.51676812
117EIF2AK20.49998494
118CSF1R0.49891633
119MAP3K80.48816265
120MAP3K130.48624214
121AURKA0.48452872
122PRKCQ0.48247021
123CSNK1G10.47591762
124IRAK30.47168408
125CDK70.46955801
126MAP4K20.46814018
127MAP2K10.43921352
128MAPK70.43191654
129PDK10.42885400
130IGF1R0.42726601
131LRRK20.42069492
132PRKCG0.41838664
133MAPKAPK20.40267826
134RET0.40090331
135CAMK2B0.39500261
136MAP3K60.38615575
137FGFR30.38461998
138ACVR1B0.37763727
139MAP3K50.37638466
140FER0.37607051
141PRKCE0.36803414
142ILK0.35950145
143RPS6KA20.35815306
144MELK0.34729459
145PDK20.33057137
146CSNK1A10.32534068
147JAK30.31333199
148CAMK40.31209049
149IKBKE0.31171708
150PHKG20.29852913
151PHKG10.29852913
152CLK10.29840125
153PRKCA0.29541582
154PAK30.28823261
155WEE10.28425234
156CDK40.27840016
157MAP3K10.27466933
158CAMK1G0.25926015
159PIK3CA0.25785420
160CSNK1G20.25651174
161MAP3K20.25067676
162IRAK20.24190757
163MTOR0.23207671
164STK380.23065644

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.08621445
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60766112
3Nitrogen metabolism_Homo sapiens_hsa009103.45280703
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19069274
5Arginine biosynthesis_Homo sapiens_hsa002202.94634394
6Tryptophan metabolism_Homo sapiens_hsa003802.70624184
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66056840
8* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65508202
9Fatty acid degradation_Homo sapiens_hsa000712.60471363
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51417691
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45638820
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44331953
13Complement and coagulation cascades_Homo sapiens_hsa046102.41750961
14Butanoate metabolism_Homo sapiens_hsa006502.33966837
15Proteasome_Homo sapiens_hsa030502.24949724
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22023417
17Peroxisome_Homo sapiens_hsa041462.12725927
18Propanoate metabolism_Homo sapiens_hsa006402.11007849
19Chemical carcinogenesis_Homo sapiens_hsa052042.01414013
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99428641
21Histidine metabolism_Homo sapiens_hsa003401.93120914
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.93062857
23Fatty acid metabolism_Homo sapiens_hsa012121.92400474
24PPAR signaling pathway_Homo sapiens_hsa033201.92194380
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87435136
26beta-Alanine metabolism_Homo sapiens_hsa004101.84604025
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.81268481
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72688325
29Retinol metabolism_Homo sapiens_hsa008301.72487404
30Caffeine metabolism_Homo sapiens_hsa002321.69623978
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67597400
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60868242
33Staphylococcus aureus infection_Homo sapiens_hsa051501.57386820
34Bile secretion_Homo sapiens_hsa049761.56792263
35Phenylalanine metabolism_Homo sapiens_hsa003601.51157514
36Selenocompound metabolism_Homo sapiens_hsa004501.50415966
37Pyruvate metabolism_Homo sapiens_hsa006201.49964221
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38933591
39Sulfur metabolism_Homo sapiens_hsa009201.37745907
40Starch and sucrose metabolism_Homo sapiens_hsa005001.33709867
41Tyrosine metabolism_Homo sapiens_hsa003501.31757101
42Other glycan degradation_Homo sapiens_hsa005111.24678102
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23609708
44ABC transporters_Homo sapiens_hsa020101.21282509
45Fat digestion and absorption_Homo sapiens_hsa049751.20000081
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.19198819
47Carbon metabolism_Homo sapiens_hsa012001.18753123
48Folate biosynthesis_Homo sapiens_hsa007901.18515432
49Biosynthesis of amino acids_Homo sapiens_hsa012301.17850648
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16617430
51Lysosome_Homo sapiens_hsa041421.15207712
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14620968
53* Fatty acid elongation_Homo sapiens_hsa000621.11757702
54Steroid biosynthesis_Homo sapiens_hsa001001.10969774
55Oxidative phosphorylation_Homo sapiens_hsa001901.06599980
56Arginine and proline metabolism_Homo sapiens_hsa003301.06047960
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05592575
58Sphingolipid metabolism_Homo sapiens_hsa006001.02962723
59N-Glycan biosynthesis_Homo sapiens_hsa005101.02652229
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01986291
61Vitamin digestion and absorption_Homo sapiens_hsa049771.00063086
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99500857
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.96364030
64Lysine degradation_Homo sapiens_hsa003100.88661152
65Collecting duct acid secretion_Homo sapiens_hsa049660.88132503
66Sulfur relay system_Homo sapiens_hsa041220.85305045
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84902945
68Mismatch repair_Homo sapiens_hsa034300.84096453
69Glycerolipid metabolism_Homo sapiens_hsa005610.77740061
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75886068
71Fanconi anemia pathway_Homo sapiens_hsa034600.75626440
72Vitamin B6 metabolism_Homo sapiens_hsa007500.74561278
73Glutathione metabolism_Homo sapiens_hsa004800.70586891
74Vibrio cholerae infection_Homo sapiens_hsa051100.66776539
75One carbon pool by folate_Homo sapiens_hsa006700.66579185
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66092866
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58578999
78Pentose phosphate pathway_Homo sapiens_hsa000300.58008882
79Pyrimidine metabolism_Homo sapiens_hsa002400.53846454
80Fatty acid biosynthesis_Homo sapiens_hsa000610.51491268
81Base excision repair_Homo sapiens_hsa034100.50721048
82* Metabolic pathways_Homo sapiens_hsa011000.46883845
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43654989
84Protein export_Homo sapiens_hsa030600.41797109
85Parkinsons disease_Homo sapiens_hsa050120.40265228
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39071252
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38990278
88Homologous recombination_Homo sapiens_hsa034400.36414623
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29574911
90Fructose and mannose metabolism_Homo sapiens_hsa000510.29481500
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29234194
92Galactose metabolism_Homo sapiens_hsa000520.27824982
93Circadian rhythm_Homo sapiens_hsa047100.25127712
94Linoleic acid metabolism_Homo sapiens_hsa005910.24283642
95Insulin resistance_Homo sapiens_hsa049310.21865372
96Nucleotide excision repair_Homo sapiens_hsa034200.21850280
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.21322009
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20514146
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19507928
100Phototransduction_Homo sapiens_hsa047440.18542264
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.15215340
102Huntingtons disease_Homo sapiens_hsa050160.14954544
103Glucagon signaling pathway_Homo sapiens_hsa049220.10420511
104Prion diseases_Homo sapiens_hsa050200.04667315
105AMPK signaling pathway_Homo sapiens_hsa041520.03806563
106Type II diabetes mellitus_Homo sapiens_hsa04930-0.2642527
107Ether lipid metabolism_Homo sapiens_hsa00565-0.2537257
108Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2501727
109Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2454245
110Protein digestion and absorption_Homo sapiens_hsa04974-0.2179220
111Hepatitis C_Homo sapiens_hsa05160-0.2087150
112Mineral absorption_Homo sapiens_hsa04978-0.1866369
113African trypanosomiasis_Homo sapiens_hsa05143-0.1828784
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1812975
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1771163
116Regulation of autophagy_Homo sapiens_hsa04140-0.1529598
117Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1493511
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1447624
119Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1421062
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1225604
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1212397
122Insulin signaling pathway_Homo sapiens_hsa04910-0.1042670
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0900575
124Renin-angiotensin system_Homo sapiens_hsa04614-0.0738474
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0544902
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0234087

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