ACOT13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.04230906
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.86669388
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.48424892
4ATP synthesis coupled proton transport (GO:0015986)7.48424892
5respiratory electron transport chain (GO:0022904)7.32895526
6electron transport chain (GO:0022900)7.13660183
7tricarboxylic acid cycle (GO:0006099)6.28283376
8oxidative phosphorylation (GO:0006119)5.39782893
9NADH metabolic process (GO:0006734)5.18865721
10establishment of protein localization to mitochondrial membrane (GO:0090151)5.03150756
11regulation of acyl-CoA biosynthetic process (GO:0050812)4.73621005
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.69100214
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.64525958
14ATP biosynthetic process (GO:0006754)4.56465411
15succinate metabolic process (GO:0006105)4.53847055
16sarcomere organization (GO:0045214)4.50339440
17rRNA modification (GO:0000154)4.38517703
18regulation of cofactor metabolic process (GO:0051193)4.36111948
19regulation of coenzyme metabolic process (GO:0051196)4.36111948
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.36029330
21water-soluble vitamin biosynthetic process (GO:0042364)4.34917067
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.26359479
23protein neddylation (GO:0045116)4.26121195
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20010558
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.20010558
26NADH dehydrogenase complex assembly (GO:0010257)4.20010558
27hydrogen ion transmembrane transport (GO:1902600)4.17666493
28protein complex biogenesis (GO:0070271)4.16472593
29inner mitochondrial membrane organization (GO:0007007)4.16340215
30cardiac myofibril assembly (GO:0055003)4.11505426
31rRNA methylation (GO:0031167)4.08692668
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.05426155
33regulation of oxidative phosphorylation (GO:0002082)3.99974994
34protein-cofactor linkage (GO:0018065)3.98775551
35respiratory chain complex IV assembly (GO:0008535)3.95588550
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.95108200
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.94615905
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.94490146
39oxaloacetate metabolic process (GO:0006107)3.93256879
40regulation of cell communication by electrical coupling (GO:0010649)3.90261516
41regulation of relaxation of muscle (GO:1901077)3.82952468
42cardiac muscle contraction (GO:0060048)3.81467151
43mitochondrial respiratory chain complex assembly (GO:0033108)3.81183884
44heart contraction (GO:0060047)3.79015807
45heart process (GO:0003015)3.79015807
46cytochrome complex assembly (GO:0017004)3.77562019
47myofibril assembly (GO:0030239)3.75479295
48aerobic respiration (GO:0009060)3.74268153
49aspartate family amino acid catabolic process (GO:0009068)3.73482645
50ribosomal small subunit biogenesis (GO:0042274)3.73171691
51lysine metabolic process (GO:0006553)3.66432857
52lysine catabolic process (GO:0006554)3.66432857
53proton transport (GO:0015992)3.65649134
54regulation of actin filament-based movement (GO:1903115)3.64754851
55hydrogen transport (GO:0006818)3.62624987
56proteasome assembly (GO:0043248)3.62606120
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61143521
58viral transcription (GO:0019083)3.60941041
59cellular ketone body metabolic process (GO:0046950)3.60654594
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59781414
61translational termination (GO:0006415)3.59374994
62regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.56415883
63branched-chain amino acid catabolic process (GO:0009083)3.56147803
64muscle filament sliding (GO:0030049)3.55363116
65actin-myosin filament sliding (GO:0033275)3.55363116
66fatty acid beta-oxidation (GO:0006635)3.54774984
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54301527
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54301527
69cotranslational protein targeting to membrane (GO:0006613)3.51313705
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50970267
712-oxoglutarate metabolic process (GO:0006103)3.50831181
72short-chain fatty acid metabolic process (GO:0046459)3.48997724
73ribosomal large subunit biogenesis (GO:0042273)3.47535284
74sarcoplasmic reticulum calcium ion transport (GO:0070296)3.45115734
75protein targeting to ER (GO:0045047)3.44824779
76negative regulation of potassium ion transmembrane transport (GO:1901380)3.43902906
77negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.43807718
78ribonucleoside triphosphate biosynthetic process (GO:0009201)3.41596775
79transcription elongation from RNA polymerase III promoter (GO:0006385)3.39274972
80termination of RNA polymerase III transcription (GO:0006386)3.39274972
81regulation of sulfur metabolic process (GO:0042762)3.38841934
82chaperone-mediated protein transport (GO:0072321)3.37750896
83quinone biosynthetic process (GO:1901663)3.33929468
84ubiquinone biosynthetic process (GO:0006744)3.33929468
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32112023
86protein localization to endoplasmic reticulum (GO:0070972)3.28137500
87fatty acid catabolic process (GO:0009062)3.24666849
88pseudouridine synthesis (GO:0001522)3.23489443
89detection of calcium ion (GO:0005513)3.16075132
90generation of precursor metabolites and energy (GO:0006091)3.15579587
91regulation of sarcomere organization (GO:0060297)3.15095951
92ventricular cardiac muscle cell action potential (GO:0086005)3.14315758
93DNA deamination (GO:0045006)3.13144723
94ketone body metabolic process (GO:1902224)3.10940643
95meiotic chromosome segregation (GO:0045132)3.10206664
96behavioral response to nicotine (GO:0035095)3.10157772
97regulation of striated muscle contraction (GO:0006942)3.09442007
98cellular respiration (GO:0045333)3.08628155
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08131647
100ATP hydrolysis coupled proton transport (GO:0015991)3.08131647
101fatty acid oxidation (GO:0019395)3.07946818
102cardiac muscle tissue morphogenesis (GO:0055008)3.07840270
103regulation of cellular respiration (GO:0043457)3.07625156
104branched-chain amino acid metabolic process (GO:0009081)3.07278880
105platelet dense granule organization (GO:0060155)3.05658075
106ribosomal small subunit assembly (GO:0000028)3.05204948
107lipid oxidation (GO:0034440)3.04824348
108translation (GO:0006412)3.03866176
109carnitine shuttle (GO:0006853)3.02558781
110translational elongation (GO:0006414)3.01647771
111regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.01207231
112intracellular protein transmembrane import (GO:0044743)3.01148663
113cellular component biogenesis (GO:0044085)2.99457352
114regulation of mitochondrial translation (GO:0070129)2.98516369
115nucleoside triphosphate biosynthetic process (GO:0009142)2.98314126
116ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.94231891
117regulation of skeletal muscle contraction (GO:0014819)2.93816171
118bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93289887
119protein targeting to mitochondrion (GO:0006626)2.92872516
120negative regulation of calcium ion transmembrane transport (GO:1903170)2.91362748
121negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.91362748
122striated muscle contraction (GO:0006941)2.91083127
123ubiquinone metabolic process (GO:0006743)2.90653212
124acetyl-CoA metabolic process (GO:0006084)2.89958099
125actin-mediated cell contraction (GO:0070252)2.88999736
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88803231
127monocarboxylic acid catabolic process (GO:0072329)2.87840345
128regulation of membrane repolarization (GO:0060306)2.86599879
129regulation of cardiac muscle contraction (GO:0055117)2.86307543
130cardiac muscle hypertrophy (GO:0003300)2.85634329
131cardiac muscle cell development (GO:0055013)2.85128487
132mitochondrial RNA metabolic process (GO:0000959)2.83827638
133regulation of sequestering of triglyceride (GO:0010889)2.82901527
134cullin deneddylation (GO:0010388)2.82010203
135mitochondrial transport (GO:0006839)2.81520686
136negative regulation of protein localization to cell surface (GO:2000009)2.79506305
137chromatin remodeling at centromere (GO:0031055)2.79206993
138adult heart development (GO:0007512)2.79186367
139tryptophan catabolic process (GO:0006569)2.78907949
140indole-containing compound catabolic process (GO:0042436)2.78907949
141indolalkylamine catabolic process (GO:0046218)2.78907949
142establishment of protein localization to mitochondrion (GO:0072655)2.78474389
143protein localization to mitochondrion (GO:0070585)2.76919895
144tRNA processing (GO:0008033)2.76863456
145C-terminal protein lipidation (GO:0006501)2.74884861
146pteridine-containing compound biosynthetic process (GO:0042559)2.74793119
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74650786
148CENP-A containing nucleosome assembly (GO:0034080)2.70098522
149signal peptide processing (GO:0006465)2.69876839
150replication fork processing (GO:0031297)2.68769482
151maturation of SSU-rRNA (GO:0030490)2.68499886
152translational initiation (GO:0006413)2.68330357
153kynurenine metabolic process (GO:0070189)2.66848285
154rRNA processing (GO:0006364)2.66425851
155aromatic amino acid family catabolic process (GO:0009074)2.65642429
156regulation of cellular amino acid metabolic process (GO:0006521)2.65150415
157viral life cycle (GO:0019058)2.64883634
158rRNA metabolic process (GO:0016072)2.62758303
159cellular protein complex disassembly (GO:0043624)2.57875346
160protein deneddylation (GO:0000338)2.57490483
161preassembly of GPI anchor in ER membrane (GO:0016254)2.55411025
162vitamin biosynthetic process (GO:0009110)2.55202874
163adenosine metabolic process (GO:0046085)2.54529478
164positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52416159
165C-terminal protein amino acid modification (GO:0018410)2.51776297
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50942414
167L-phenylalanine catabolic process (GO:0006559)2.50718719
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50718719
169purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.50713058
170purine nucleoside monophosphate biosynthetic process (GO:0009127)2.50713058
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.50707769
172purine nucleobase biosynthetic process (GO:0009113)2.49022720
173reciprocal meiotic recombination (GO:0007131)2.48649765
174reciprocal DNA recombination (GO:0035825)2.48649765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.00993381
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.65700322
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69558116
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.03453828
5EZH2_22144423_ChIP-Seq_EOC_Human2.92301410
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.70322692
7ELK1_19687146_ChIP-ChIP_HELA_Human2.56941256
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42189545
9VDR_22108803_ChIP-Seq_LS180_Human2.35723109
10VDR_23849224_ChIP-Seq_CD4+_Human2.31501688
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29502978
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.22909432
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.08639423
14TAF15_26573619_Chip-Seq_HEK293_Human2.05455033
15GBX2_23144817_ChIP-Seq_PC3_Human2.03974791
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02697197
17EWS_26573619_Chip-Seq_HEK293_Human2.00603374
18* FOXP3_21729870_ChIP-Seq_TREG_Human1.93118429
19MYC_18940864_ChIP-ChIP_HL60_Human1.91642198
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.89688667
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.87935659
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.87674079
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85052859
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78304714
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77368319
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74592869
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73490354
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73262154
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67907607
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.66237349
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64601198
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61652933
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.58842703
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58464559
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56967059
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54687561
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51588377
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50892309
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50283151
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48284233
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46379707
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46218310
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42308248
44TP53_22573176_ChIP-Seq_HFKS_Human1.40631093
45TTF2_22483619_ChIP-Seq_HELA_Human1.35591708
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35313782
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34265854
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33741007
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33703788
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33438410
51IGF1R_20145208_ChIP-Seq_DFB_Human1.32551271
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32465386
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31300280
54HTT_18923047_ChIP-ChIP_STHdh_Human1.30323091
55DCP1A_22483619_ChIP-Seq_HELA_Human1.29902770
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.28374333
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27927886
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27115320
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26499544
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.26001226
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26001226
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25431642
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25290217
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25078328
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23682515
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23190013
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23033770
68* TBX20_22080862_ChIP-Seq_HEART_Mouse1.23015262
69* TBX20_22328084_ChIP-Seq_HEART_Mouse1.23015262
70GABP_19822575_ChIP-Seq_HepG2_Human1.22922237
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22503812
72* AR_20517297_ChIP-Seq_VCAP_Human1.20326582
73IRF1_19129219_ChIP-ChIP_H3396_Human1.17261248
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.16287218
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16137011
76P300_19829295_ChIP-Seq_ESCs_Human1.16042642
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14040613
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13811881
79ZNF274_21170338_ChIP-Seq_K562_Hela1.12928719
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12743939
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12692030
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12690317
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11983546
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11983546
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11555440
86BCAT_22108803_ChIP-Seq_LS180_Human1.11077280
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.10956272
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10258007
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09396675
90XRN2_22483619_ChIP-Seq_HELA_Human1.09318956
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09085528
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07660382
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07241775
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06661990
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06156274
96ER_23166858_ChIP-Seq_MCF-7_Human1.05913355
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04915475
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.04737995
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.04588945
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04369614
101NCOR_22424771_ChIP-Seq_293T_Human1.04222518
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03468257
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03155972
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02841385
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02328998
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00975069
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00743568
108SMAD4_21799915_ChIP-Seq_A2780_Human1.00230623
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99604729
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.99556427
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99541482
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98047300
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.97930898
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.97433735
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97218893
116GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96571263
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.95174562
118ETS1_20019798_ChIP-Seq_JURKAT_Human0.94801688
119BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94650852
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93884497
121SOX2_19829295_ChIP-Seq_ESCs_Human0.93857153
122NANOG_19829295_ChIP-Seq_ESCs_Human0.93857153
123EZH2_27304074_Chip-Seq_ESCs_Mouse0.93658303
124ERG_20517297_ChIP-Seq_VCAP_Human0.93076002
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92946945
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92600915
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92372704
128REST_18959480_ChIP-ChIP_MESCs_Mouse0.91699168
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91058918
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90866601
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90705043
132RBPJ_21746931_ChIP-Seq_IB4_Human0.90624044
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89779631
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88999726
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88908294
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88791762
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88420310
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88104425
139HOXB7_26014856_ChIP-Seq_BT474_Human0.87573140
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.87435345
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87004758
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87004758
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86952481
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86905257
145GATA1_22025678_ChIP-Seq_K562_Human0.86455814
146* FOXH1_21741376_ChIP-Seq_EPCs_Human0.86126498
147EOMES_21245162_ChIP-Seq_HESCs_Human0.86078040
148FUS_26573619_Chip-Seq_HEK293_Human0.85768342
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.85166341
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81971858
151REST_21632747_ChIP-Seq_MESCs_Mouse0.81718917
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78913486
153EZH2_27294783_Chip-Seq_ESCs_Mouse0.78564453
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78337836
155CBP_20019798_ChIP-Seq_JUKART_Human0.78337836
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78279668
157THAP11_20581084_ChIP-Seq_MESCs_Mouse0.78134750
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77699455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.88028883
2MP0003646_muscle_fatigue4.83599111
3MP0004215_abnormal_myocardial_fiber3.84039104
4MP0004084_abnormal_cardiac_muscle3.79391278
5MP0000751_myopathy3.69042439
6MP0004036_abnormal_muscle_relaxation3.40115051
7MP0000749_muscle_degeneration3.15471181
8MP0006036_abnormal_mitochondrial_physio3.04987032
9MP0005330_cardiomyopathy2.94081346
10MP0006072_abnormal_retinal_apoptosis2.56321893
11MP0006292_abnormal_olfactory_placode2.43642153
12MP0009379_abnormal_foot_pigmentation2.42352764
13MP0003011_delayed_dark_adaptation2.41260777
14MP0002972_abnormal_cardiac_muscle2.40471850
15MP0003806_abnormal_nucleotide_metabolis2.29753486
16MP0005646_abnormal_pituitary_gland2.28134394
17MP0004484_altered_response_of2.26571909
18MP0008877_abnormal_DNA_methylation2.24765292
19MP0003137_abnormal_impulse_conducting2.22206413
20MP0002139_abnormal_hepatobiliary_system2.13912982
21MP0004043_abnormal_pH_regulation2.13677862
22MP0008775_abnormal_heart_ventricle2.13229422
23MP0003136_yellow_coat_color2.12851599
24MP0002938_white_spotting2.12715205
25MP0003718_maternal_effect2.09847558
26MP0006035_abnormal_mitochondrial_morpho2.08735194
27MP0005620_abnormal_muscle_contractility2.05552513
28MP0003195_calcinosis2.05389289
29MP0004130_abnormal_muscle_cell1.99664574
30MP0005551_abnormal_eye_electrophysiolog1.95921885
31MP0003880_abnormal_central_pattern1.95167907
32MP0008058_abnormal_DNA_repair1.93821870
33MP0005360_urolithiasis1.92570449
34MP0005085_abnormal_gallbladder_physiolo1.90789077
35MP0001529_abnormal_vocalization1.88592887
36MP0004087_abnormal_muscle_fiber1.87188584
37MP0004145_abnormal_muscle_electrophysio1.80296843
38MP0001544_abnormal_cardiovascular_syste1.78179029
39MP0005385_cardiovascular_system_phenoty1.78179029
40MP0004085_abnormal_heartbeat1.73933426
41MP0008872_abnormal_physiological_respon1.71743566
42MP0002822_catalepsy1.70782870
43MP0008875_abnormal_xenobiotic_pharmacok1.70316430
44MP0000372_irregular_coat_pigmentation1.70227564
45MP0002106_abnormal_muscle_physiology1.69926654
46MP0002163_abnormal_gland_morphology1.68935971
47MP0005332_abnormal_amino_acid1.67409543
48MP0006138_congestive_heart_failure1.67272075
49MP0005253_abnormal_eye_physiology1.65980031
50MP0000747_muscle_weakness1.61422551
51MP0003787_abnormal_imprinting1.58842364
52MP0002269_muscular_atrophy1.58683347
53MP0000750_abnormal_muscle_regeneration1.58644251
54MP0005379_endocrine/exocrine_gland_phen1.56219439
55MP0004885_abnormal_endolymph1.52941622
56MP0002332_abnormal_exercise_endurance1.42841710
57MP0003221_abnormal_cardiomyocyte_apopto1.42472480
58MP0002138_abnormal_hepatobiliary_system1.42284958
59MP0004019_abnormal_vitamin_homeostasis1.37015739
60MP0005369_muscle_phenotype1.36667387
61MP0002160_abnormal_reproductive_system1.32509246
62MP0005645_abnormal_hypothalamus_physiol1.28127844
63MP0001905_abnormal_dopamine_level1.26542142
64MP0005365_abnormal_bile_salt1.25506188
65MP0010630_abnormal_cardiac_muscle1.25255728
66MP0002102_abnormal_ear_morphology1.24482212
67MP0005535_abnormal_body_temperature1.24082351
68MP0000759_abnormal_skeletal_muscle1.23103728
69MP0004133_heterotaxia1.22688791
70MP0000230_abnormal_systemic_arterial1.22144113
71MP0005389_reproductive_system_phenotype1.21188303
72MP0005174_abnormal_tail_pigmentation1.20778486
73MP0005410_abnormal_fertilization1.20224027
74MP0003186_abnormal_redox_activity1.19744115
75MP0004142_abnormal_muscle_tone1.18501026
76MP0001485_abnormal_pinna_reflex1.17832044
77MP0001984_abnormal_olfaction1.16383937
78MP0008789_abnormal_olfactory_epithelium1.15893183
79MP0005165_increased_susceptibility_to1.15180828
80MP0006276_abnormal_autonomic_nervous1.14603519
81MP0001986_abnormal_taste_sensitivity1.14283597
82MP0001756_abnormal_urination1.12179119
83MP0004147_increased_porphyrin_level1.12083953
84MP0004510_myositis1.12075817
85MP0001188_hyperpigmentation1.11216434
86MP0002272_abnormal_nervous_system1.11131689
87MP0005408_hypopigmentation1.10701611
88MP0009745_abnormal_behavioral_response1.10189223
89MP0000631_abnormal_neuroendocrine_gland1.09856819
90MP0005584_abnormal_enzyme/coenzyme_acti1.09850526
91MP0002064_seizures1.09762814
92MP0010386_abnormal_urinary_bladder1.09340601
93MP0002127_abnormal_cardiovascular_syste1.09312683
94MP0004233_abnormal_muscle_weight1.07479151
95MP0002736_abnormal_nociception_after1.06768664
96MP0000013_abnormal_adipose_tissue1.05889734
97MP0003828_pulmonary_edema1.03895173
98MP0009046_muscle_twitch1.03720954
99MP0002095_abnormal_skin_pigmentation1.02520415
100MP0002090_abnormal_vision1.01955984
101MP0001440_abnormal_grooming_behavior1.01876936
102MP0001919_abnormal_reproductive_system1.01794878
103MP0000343_altered_response_to1.01680488
104MP0005266_abnormal_metabolism1.01376565
105MP0005386_behavior/neurological_phenoty1.00300456
106MP0004924_abnormal_behavior1.00300456
107MP0003252_abnormal_bile_duct0.99767676
108MP0003950_abnormal_plasma_membrane0.97808052
109MP0005083_abnormal_biliary_tract0.97325238
110MP0001324_abnormal_eye_pigmentation0.97236464
111MP0009697_abnormal_copulation0.95405065
112MP0003635_abnormal_synaptic_transmissio0.94122253
113MP0003121_genomic_imprinting0.92485446
114MP0002210_abnormal_sex_determination0.91730796
115MP0005319_abnormal_enzyme/_coenzyme0.91703357
116MP0001968_abnormal_touch/_nociception0.91137851
117MP0003329_amyloid_beta_deposits0.90309218
118MP0002653_abnormal_ependyma_morphology0.89849292
119MP0005636_abnormal_mineral_homeostasis0.89801214
120MP0005670_abnormal_white_adipose0.88321612
121MP0005195_abnormal_posterior_eye0.87709104
122MP0004957_abnormal_blastocyst_morpholog0.87640483
123MP0004859_abnormal_synaptic_plasticity0.87192956
124MP0003693_abnormal_embryo_hatching0.86470371
125MP0002118_abnormal_lipid_homeostasis0.85504345
126MP0002876_abnormal_thyroid_physiology0.85124716
127MP0002909_abnormal_adrenal_gland0.84956870
128MP0003786_premature_aging0.84888240
129MP0002928_abnormal_bile_duct0.84594125
130MP0009643_abnormal_urine_homeostasis0.83736875
131MP0002277_abnormal_respiratory_mucosa0.83723447
132MP0000647_abnormal_sebaceous_gland0.83599487
133MP0005451_abnormal_body_composition0.83596382
134MP0002693_abnormal_pancreas_physiology0.83071736
135MP0002078_abnormal_glucose_homeostasis0.81805674
136MP0003123_paternal_imprinting0.80256934
137MP0002735_abnormal_chemical_nociception0.80243439
138MP0004742_abnormal_vestibular_system0.79355223
139MP0008995_early_reproductive_senescence0.79016219
140MP0002557_abnormal_social/conspecific_i0.78574103
141MP0000653_abnormal_sex_gland0.76795322
142MP0002067_abnormal_sensory_capabilities0.76668228
143MP0000427_abnormal_hair_cycle0.76596544
144MP0002572_abnormal_emotion/affect_behav0.76505861
145MP0001944_abnormal_pancreas_morphology0.75578221
146MP0005075_abnormal_melanosome_morpholog0.75514198
147MP0001929_abnormal_gametogenesis0.75406705
148MP0001764_abnormal_homeostasis0.74724367
149MP0005666_abnormal_adipose_tissue0.73881521
150MP0002638_abnormal_pupillary_reflex0.73446632
151MP0003656_abnormal_erythrocyte_physiolo0.73378100
152MP0001666_abnormal_nutrient_absorption0.71354983
153MP0002063_abnormal_learning/memory/cond0.71297881
154MP0001145_abnormal_male_reproductive0.70803652
155MP0010329_abnormal_lipoprotein_level0.70506645
156MP0009840_abnormal_foam_cell0.70446247
157MP0005084_abnormal_gallbladder_morpholo0.70311177
158MP0001765_abnormal_ion_homeostasis0.69193193
159MP0001501_abnormal_sleep_pattern0.67664858
160MP0005376_homeostasis/metabolism_phenot0.64260570
161MP0004270_analgesia0.63529341
162MP0001970_abnormal_pain_threshold0.61852851

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.33842100
2Abnormal mitochondria in muscle tissue (HP:0008316)6.09685376
3Acute encephalopathy (HP:0006846)5.68242849
4Progressive macrocephaly (HP:0004481)5.35977587
5Mitochondrial inheritance (HP:0001427)5.33033608
6Hepatic necrosis (HP:0002605)5.23821934
7Hepatocellular necrosis (HP:0001404)5.13139679
8Increased CSF lactate (HP:0002490)4.79534288
9Cerebral edema (HP:0002181)4.65934806
10Sudden death (HP:0001699)4.57555007
11Calf muscle hypertrophy (HP:0008981)3.98002240
12Lactic acidosis (HP:0003128)3.87197114
13Muscle hypertrophy of the lower extremities (HP:0008968)3.82176164
14Abnormality of glycolysis (HP:0004366)3.81172753
15Increased serum pyruvate (HP:0003542)3.81172753
16Exercise-induced myalgia (HP:0003738)3.72348300
17Exercise-induced muscle cramps (HP:0003710)3.70376458
18Palpitations (HP:0001962)3.67852011
19Respiratory failure (HP:0002878)3.66607327
20Myoglobinuria (HP:0002913)3.61238444
21Ventricular tachycardia (HP:0004756)3.60570809
22Increased muscle lipid content (HP:0009058)3.59203946
23Increased intramyocellular lipid droplets (HP:0012240)3.57728621
24Exercise intolerance (HP:0003546)3.57701517
25Lipid accumulation in hepatocytes (HP:0006561)3.43994365
26Atrial fibrillation (HP:0005110)3.43360792
27Neuroendocrine neoplasm (HP:0100634)3.35510779
28Pheochromocytoma (HP:0002666)3.34641529
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32554239
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32554239
31Ketoacidosis (HP:0001993)3.29376395
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25633483
33Dicarboxylic aciduria (HP:0003215)3.25633483
34Primary atrial arrhythmia (HP:0001692)3.21679664
35Increased hepatocellular lipid droplets (HP:0006565)3.21061030
36Syncope (HP:0001279)3.15075418
37Supraventricular tachycardia (HP:0004755)3.14604111
38Optic disc pallor (HP:0000543)3.11695121
39Molar tooth sign on MRI (HP:0002419)3.06549916
40Abnormality of midbrain morphology (HP:0002418)3.06549916
41Abnormality of the calf musculature (HP:0001430)3.06072908
42Supraventricular arrhythmia (HP:0005115)3.03592239
43Increased serum lactate (HP:0002151)3.01924464
44Hypoglycemic coma (HP:0001325)3.01445312
45Abnormality of fatty-acid metabolism (HP:0004359)3.01037559
46Lethargy (HP:0001254)2.96705864
47Leukodystrophy (HP:0002415)2.96043200
48Rhabdomyolysis (HP:0003201)2.94316344
49Pancreatic cysts (HP:0001737)2.93382547
50Lipoatrophy (HP:0100578)2.92741876
51Abnormality of alanine metabolism (HP:0010916)2.92515999
52Hyperalaninemia (HP:0003348)2.92515999
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92515999
54Ketosis (HP:0001946)2.86723638
55Pancreatic fibrosis (HP:0100732)2.83645934
56Muscle fiber splitting (HP:0003555)2.83193100
57Generalized aminoaciduria (HP:0002909)2.82640276
58Abnormality of cells of the erythroid lineage (HP:0012130)2.80920816
59Abnormal number of erythroid precursors (HP:0012131)2.78502823
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74023165
61Dilated cardiomyopathy (HP:0001644)2.69432328
62Conjunctival hamartoma (HP:0100780)2.69240969
63Renal Fanconi syndrome (HP:0001994)2.62731263
64Abnormality of renal resorption (HP:0011038)2.62602698
65Macrocytic anemia (HP:0001972)2.59899059
66Congenital, generalized hypertrichosis (HP:0004540)2.59519843
67Medial flaring of the eyebrow (HP:0010747)2.57736694
68CNS demyelination (HP:0007305)2.57221383
69Ragged-red muscle fibers (HP:0003200)2.55937598
70Abnormality of serum amino acid levels (HP:0003112)2.55813351
71Methylmalonic aciduria (HP:0012120)2.54872620
72Prolonged QT interval (HP:0001657)2.53753831
73True hermaphroditism (HP:0010459)2.53683727
74Nephronophthisis (HP:0000090)2.52897697
75Metabolic acidosis (HP:0001942)2.49737661
76Exertional dyspnea (HP:0002875)2.48354248
77Hyperammonemia (HP:0001987)2.46403639
78Vomiting (HP:0002013)2.46016127
79Glycosuria (HP:0003076)2.45672606
80Abnormality of urine glucose concentration (HP:0011016)2.45672606
813-Methylglutaconic aciduria (HP:0003535)2.43953678
82EMG: myopathic abnormalities (HP:0003458)2.42804369
83Right ventricular cardiomyopathy (HP:0011663)2.40176993
84Hyperglycinuria (HP:0003108)2.39165415
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37375525
86Methylmalonic acidemia (HP:0002912)2.33523131
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31561598
88Abnormality of methionine metabolism (HP:0010901)2.28409433
89Abnormality of the renal cortex (HP:0011035)2.28253922
90Reticulocytopenia (HP:0001896)2.27538985
91Myotonia (HP:0002486)2.26933191
92Hyporeflexia of lower limbs (HP:0002600)2.26538142
93Congenital stationary night blindness (HP:0007642)2.26054755
94Ventricular arrhythmia (HP:0004308)2.25701135
95Renal cortical cysts (HP:0000803)2.25619684
96Neoplasm of head and neck (HP:0012288)2.25566969
97Esophageal neoplasm (HP:0100751)2.25566969
98Left ventricular hypertrophy (HP:0001712)2.25375881
99Abnormality of serine family amino acid metabolism (HP:0010894)2.24460719
100Abnormality of glycine metabolism (HP:0010895)2.24460719
101Proximal tubulopathy (HP:0000114)2.24169451
102X-linked dominant inheritance (HP:0001423)2.23333341
103Cerebral hemorrhage (HP:0001342)2.23308769
104Bundle branch block (HP:0011710)2.23179459
105Hyperphosphaturia (HP:0003109)2.19107829
106Abolished electroretinogram (ERG) (HP:0000550)2.15693186
107Asymmetric septal hypertrophy (HP:0001670)2.14206700
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11807676
109Ventricular fibrillation (HP:0001663)2.10556612
110Emotional lability (HP:0000712)2.08791500
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07840695
112Abnormality of the left ventricular outflow tract (HP:0011103)2.07241785
113Subaortic stenosis (HP:0001682)2.07241785
114Hyperglycinemia (HP:0002154)2.06440766
115Muscle stiffness (HP:0003552)2.05930545
116Abnormality of the renal medulla (HP:0100957)2.04799542
117Heart block (HP:0012722)2.04578038
118Respiratory difficulties (HP:0002880)2.00935951
119Attenuation of retinal blood vessels (HP:0007843)1.98986957
120Abnormality of sulfur amino acid metabolism (HP:0004339)1.98352421
121Chronic hepatic failure (HP:0100626)1.98197524
122Pendular nystagmus (HP:0012043)1.97800454
123Gout (HP:0001997)1.96076853
124Abnormal rod and cone electroretinograms (HP:0008323)1.94020813
125Colon cancer (HP:0003003)1.93386615
126Abnormal drinking behavior (HP:0030082)1.92677369
127Polydipsia (HP:0001959)1.92677369
128Gliosis (HP:0002171)1.92089965
129Abnormal EKG (HP:0003115)1.91226653
130Hyperventilation (HP:0002883)1.91222161
131Constricted visual fields (HP:0001133)1.90313803
132Atrioventricular block (HP:0001678)1.89281462
133Type I transferrin isoform profile (HP:0003642)1.88424472
134Abnormal biliary tract physiology (HP:0012439)1.87614170
135Bile duct proliferation (HP:0001408)1.87614170
136Pallor (HP:0000980)1.87328372
137Congenital primary aphakia (HP:0007707)1.87042589
138Nephrogenic diabetes insipidus (HP:0009806)1.85779978
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85298732
140Abnormality of vitamin B metabolism (HP:0004340)1.82533180
141Gait imbalance (HP:0002141)1.81409679
142Sclerocornea (HP:0000647)1.79559053
143Absent thumb (HP:0009777)1.78107016
144Abnormality of the labia minora (HP:0012880)1.75973966
145Decreased central vision (HP:0007663)1.75394582
146Hypothermia (HP:0002045)1.74269180
147Thyroid-stimulating hormone excess (HP:0002925)1.71158540
148Hypoplasia of the pons (HP:0012110)1.71044801
149Abnormal urine phosphate concentration (HP:0012599)1.69741313
150Homocystinuria (HP:0002156)1.69634458
151Abnormality of homocysteine metabolism (HP:0010919)1.69634458
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69562673
153Type II lissencephaly (HP:0007260)1.69279770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.00058228
2BCKDK3.82972455
3FRK3.60594290
4PDK43.37276834
5PDK33.37276834
6OBSCN3.11056695
7LMTK22.91820972
8VRK22.81925110
9TTN2.73007603
10PHKG22.67666552
11PHKG12.67666552
12BMPR1B2.64124651
13NUAK12.58731935
14MUSK2.53436823
15ACVR1B2.52233622
16MAP3K122.43864294
17NME12.43025263
18MAP4K22.40246216
19GRK72.36045932
20WNK42.31109059
21NME22.29501746
22ARAF2.29344761
23PINK12.28054652
24PDK22.22943537
25STK392.10617411
26TLK12.02682209
27GRK11.84813334
28OXSR11.84700681
29VRK11.76555099
30GRK51.76290760
31CASK1.74568734
32STK241.68956330
33MST41.65563455
34EIF2AK31.60929959
35CAMK2D1.60095980
36MAP2K71.57443672
37PIK3CA1.52982767
38BUB11.43742084
39MAP3K41.43537517
40EIF2AK11.43514544
41EPHA41.39074755
42SRPK11.37683670
43CDC71.35251650
44DYRK21.34677641
45PLK31.33304265
46CAMK2A1.28064421
47STK38L1.28018448
48MAP2K41.24750476
49TAF11.22767883
50NEK11.17395885
51TAOK31.16469659
52CAMK2G1.13841646
53MKNK21.13689628
54BRSK21.13313145
55PLK41.06237676
56PAK31.06122981
57TIE11.03074893
58PLK21.02971603
59DAPK31.01572662
60MAPKAPK51.01314931
61MAP3K90.99009775
62BLK0.98128943
63PTK2B0.97482170
64CAMK2B0.96903583
65INSRR0.96401025
66CDK190.96298960
67TXK0.92908414
68MAPK120.88861180
69DMPK0.88814980
70PRKCE0.88602079
71BMPR20.88513591
72PLK10.84921491
73WNK30.82479500
74NTRK30.81146372
75CAMKK20.79980221
76DYRK30.78879769
77CSNK1G10.78500364
78TRIM280.77372348
79ILK0.76787275
80CSNK1G20.76304750
81BRAF0.72800609
82CSNK1G30.72024525
83PRKACA0.71965613
84MKNK10.71607028
85ABL20.69954060
86PKN10.68737671
87DAPK20.65726720
88ROCK20.65354079
89STK160.65339114
90PRKD10.65214254
91PRKCI0.64006072
92PNCK0.63909354
93CAMK1D0.61666688
94CAMK10.59496326
95MAP2K60.58755647
96ROCK10.58065839
97RIPK40.57913507
98CSNK2A20.57547857
99CAMK1G0.56832924
100WEE10.55922588
101STK30.55565802
102PRKCG0.55187394
103MAPK130.54999066
104TGFBR10.54871898
105FLT30.54288168
106ADRBK10.53203470
107CSNK1E0.51986036
108ZAK0.51802747
109CSNK2A10.51255005
110CSNK1A10.50954609
111IKBKB0.50008612
112MAP3K110.49952818
113MAP3K50.49698571
114RPS6KA50.49344673
115PDPK10.47743173
116DAPK10.46834175
117ADRBK20.46797489
118BCR0.46693708
119MINK10.46663283
120SGK4940.46626550
121SGK2230.46626550
122TEC0.44367415
123PRKACB0.44100172
124TTK0.43981554
125PRKACG0.43387212
126MAPKAPK30.42988706
127LIMK10.42491485
128NLK0.42021014
129WNK10.41967313
130ERBB30.41014985
131TNIK0.40946886
132CSNK1A1L0.40190971
133MAP3K70.39095384
134PRKCQ0.38825970
135AURKB0.38332762
136CAMK40.37004478
137TRPM70.36607272
138PRKAA20.33486655
139PRKG20.32887654
140PRKAA10.32554827
141PRKCA0.32424137
142KDR0.31321578
143PBK0.31186076
144CDK50.27527998
145PKN20.27464148
146PIM20.27120216
147PRKG10.26450224
148MAP3K30.26322459
149PDK10.24913379
150RPS6KL10.24159732
151RPS6KC10.24159732
152CDC42BPA0.23283912
153NTRK10.20327154
154PIK3CG0.19948024

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.22650757
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.57725261
3Parkinsons disease_Homo sapiens_hsa050124.54980932
4Alzheimers disease_Homo sapiens_hsa050103.46066002
5Cardiac muscle contraction_Homo sapiens_hsa042603.18695194
6Propanoate metabolism_Homo sapiens_hsa006403.11625868
7Huntingtons disease_Homo sapiens_hsa050163.01552087
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.92958772
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91976988
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58369911
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43122800
12Pyruvate metabolism_Homo sapiens_hsa006202.29659318
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21803855
14Fatty acid degradation_Homo sapiens_hsa000712.15960285
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03593270
16Carbon metabolism_Homo sapiens_hsa012002.03282925
17Fatty acid elongation_Homo sapiens_hsa000621.99281720
18One carbon pool by folate_Homo sapiens_hsa006701.96196332
19Butanoate metabolism_Homo sapiens_hsa006501.95572544
20Caffeine metabolism_Homo sapiens_hsa002321.92046132
21Homologous recombination_Homo sapiens_hsa034401.91370736
22Mismatch repair_Homo sapiens_hsa034301.65573455
23Collecting duct acid secretion_Homo sapiens_hsa049661.65298711
24Fatty acid metabolism_Homo sapiens_hsa012121.64700548
25Sulfur metabolism_Homo sapiens_hsa009201.59568724
26Basal transcription factors_Homo sapiens_hsa030221.52925293
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52645434
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48182787
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47045718
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46954030
31Peroxisome_Homo sapiens_hsa041461.42359652
32Linoleic acid metabolism_Homo sapiens_hsa005911.41817072
33RNA degradation_Homo sapiens_hsa030181.30286109
34Selenocompound metabolism_Homo sapiens_hsa004501.29231037
35Tryptophan metabolism_Homo sapiens_hsa003801.21452159
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15979835
37Fanconi anemia pathway_Homo sapiens_hsa034601.15935466
38Dilated cardiomyopathy_Homo sapiens_hsa054141.15657298
39Nitrogen metabolism_Homo sapiens_hsa009101.13203998
40Phenylalanine metabolism_Homo sapiens_hsa003601.10406967
41beta-Alanine metabolism_Homo sapiens_hsa004101.08768258
42Nucleotide excision repair_Homo sapiens_hsa034201.07691045
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07026758
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06962809
45Phototransduction_Homo sapiens_hsa047441.04734853
46Pyrimidine metabolism_Homo sapiens_hsa002401.03255354
47Proteasome_Homo sapiens_hsa030501.00622765
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.00336775
49Biosynthesis of amino acids_Homo sapiens_hsa012300.96285635
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95174941
51Arginine biosynthesis_Homo sapiens_hsa002200.95099572
52PPAR signaling pathway_Homo sapiens_hsa033200.94865235
53Protein export_Homo sapiens_hsa030600.93536071
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89467485
55Tyrosine metabolism_Homo sapiens_hsa003500.89464658
56Purine metabolism_Homo sapiens_hsa002300.89151859
57Steroid biosynthesis_Homo sapiens_hsa001000.87483391
58Vibrio cholerae infection_Homo sapiens_hsa051100.86237044
59Arginine and proline metabolism_Homo sapiens_hsa003300.84799855
60Starch and sucrose metabolism_Homo sapiens_hsa005000.84448198
61DNA replication_Homo sapiens_hsa030300.84229876
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81797985
63Metabolic pathways_Homo sapiens_hsa011000.81088463
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79201663
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77773249
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.75907245
67Ether lipid metabolism_Homo sapiens_hsa005650.74199413
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.72605331
69Spliceosome_Homo sapiens_hsa030400.71303939
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71100003
71RNA transport_Homo sapiens_hsa030130.70743675
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70430673
73Synaptic vesicle cycle_Homo sapiens_hsa047210.69934173
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68308886
75Histidine metabolism_Homo sapiens_hsa003400.65903552
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65645504
77Vitamin digestion and absorption_Homo sapiens_hsa049770.65226733
78Mineral absorption_Homo sapiens_hsa049780.63591073
79Vitamin B6 metabolism_Homo sapiens_hsa007500.62768963
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61597996
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61451442
82Ribosome_Homo sapiens_hsa030100.59494320
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58961904
84Base excision repair_Homo sapiens_hsa034100.58370068
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58304803
86Chemical carcinogenesis_Homo sapiens_hsa052040.57125445
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55670277
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53676582
89Glutathione metabolism_Homo sapiens_hsa004800.53065392
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51596773
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51194265
92Nicotine addiction_Homo sapiens_hsa050330.50746088
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50364648
94Non-homologous end-joining_Homo sapiens_hsa034500.49270928
95Calcium signaling pathway_Homo sapiens_hsa040200.47346038
96GABAergic synapse_Homo sapiens_hsa047270.47196141
97Taste transduction_Homo sapiens_hsa047420.47183378
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45046063
99Folate biosynthesis_Homo sapiens_hsa007900.44215981
100Fructose and mannose metabolism_Homo sapiens_hsa000510.42895615
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42218613
102Galactose metabolism_Homo sapiens_hsa000520.38059527
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36213804
104Olfactory transduction_Homo sapiens_hsa047400.36084952
105Circadian entrainment_Homo sapiens_hsa047130.35325471
106Glucagon signaling pathway_Homo sapiens_hsa049220.34934004
107Bile secretion_Homo sapiens_hsa049760.34313239
108Insulin secretion_Homo sapiens_hsa049110.33091429
109Morphine addiction_Homo sapiens_hsa050320.32978509
110Renin secretion_Homo sapiens_hsa049240.29862130
111Rheumatoid arthritis_Homo sapiens_hsa053230.28504903
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27195212
113Serotonergic synapse_Homo sapiens_hsa047260.27013744
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25696890
115Gastric acid secretion_Homo sapiens_hsa049710.25105555
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24938176
117Regulation of autophagy_Homo sapiens_hsa041400.24767121
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24490577
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23436971
120Amphetamine addiction_Homo sapiens_hsa050310.23272523
121RNA polymerase_Homo sapiens_hsa030200.21951187
122Salivary secretion_Homo sapiens_hsa049700.21896073
123Retinol metabolism_Homo sapiens_hsa008300.20267326
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20020672
125Glycerolipid metabolism_Homo sapiens_hsa005610.19709687
126Pentose phosphate pathway_Homo sapiens_hsa000300.18284490
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.16723929
128Sulfur relay system_Homo sapiens_hsa041220.16517785
129Dopaminergic synapse_Homo sapiens_hsa047280.16393728
130Glutamatergic synapse_Homo sapiens_hsa047240.15996631
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15834206
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.15461844
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.14884589
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14809909
135Fat digestion and absorption_Homo sapiens_hsa049750.14332830
136Arachidonic acid metabolism_Homo sapiens_hsa005900.13973434
137Oxytocin signaling pathway_Homo sapiens_hsa049210.12641161

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