ACOT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.46583580
2omega-hydroxylase P450 pathway (GO:0097267)8.15638580
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54937301
4L-phenylalanine catabolic process (GO:0006559)7.54937301
5L-phenylalanine metabolic process (GO:0006558)7.23451050
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23451050
7aromatic amino acid family catabolic process (GO:0009074)6.84651165
8oxidative demethylation (GO:0070989)6.40556377
9indole-containing compound catabolic process (GO:0042436)6.21694338
10indolalkylamine catabolic process (GO:0046218)6.21694338
11tryptophan catabolic process (GO:0006569)6.21694338
12glyoxylate metabolic process (GO:0046487)6.06059572
13kynurenine metabolic process (GO:0070189)5.99116677
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.96663477
15blood coagulation, intrinsic pathway (GO:0007597)5.89466202
16tryptophan metabolic process (GO:0006568)5.86224525
17bile acid biosynthetic process (GO:0006699)5.85441340
18phenylpropanoid metabolic process (GO:0009698)5.77106229
19cysteine metabolic process (GO:0006534)5.72155247
20alpha-linolenic acid metabolic process (GO:0036109)5.53114280
21urea cycle (GO:0000050)5.48378896
22urea metabolic process (GO:0019627)5.48378896
23sulfur amino acid catabolic process (GO:0000098)5.30486908
24serine family amino acid catabolic process (GO:0009071)5.25896839
25regulation of plasminogen activation (GO:0010755)5.25481225
26lysine catabolic process (GO:0006554)5.19326967
27lysine metabolic process (GO:0006553)5.19326967
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19032005
29high-density lipoprotein particle remodeling (GO:0034375)5.17850401
30negative regulation of fibrinolysis (GO:0051918)5.15183184
31nitrogen cycle metabolic process (GO:0071941)5.05909074
32homocysteine metabolic process (GO:0050667)5.04148162
33protein carboxylation (GO:0018214)5.00682206
34peptidyl-glutamic acid carboxylation (GO:0017187)5.00682206
35bile acid metabolic process (GO:0008206)4.98679714
36aromatic amino acid family metabolic process (GO:0009072)4.98092845
37regulation of fibrinolysis (GO:0051917)4.94729519
38protein activation cascade (GO:0072376)4.94185409
39negative regulation of blood coagulation (GO:0030195)4.91730789
40negative regulation of hemostasis (GO:1900047)4.91730789
41complement activation, alternative pathway (GO:0006957)4.88636984
42ethanol metabolic process (GO:0006067)4.87102027
43amino-acid betaine metabolic process (GO:0006577)4.85675604
44regulation of protein activation cascade (GO:2000257)4.84377091
45S-adenosylmethionine metabolic process (GO:0046500)4.78774843
46tyrosine metabolic process (GO:0006570)4.71091868
47alpha-amino acid catabolic process (GO:1901606)4.70789627
48alkaloid metabolic process (GO:0009820)4.64944066
49complement activation (GO:0006956)4.63918708
50cellular ketone body metabolic process (GO:0046950)4.60682016
51regulation of triglyceride catabolic process (GO:0010896)4.60080013
52regulation of cholesterol esterification (GO:0010872)4.57161226
53regulation of complement activation (GO:0030449)4.52216745
54reverse cholesterol transport (GO:0043691)4.51951981
55complement activation, classical pathway (GO:0006958)4.51826043
56hormone catabolic process (GO:0042447)4.51540219
57drug catabolic process (GO:0042737)4.50789874
58negative regulation of sterol transport (GO:0032372)4.48941393
59negative regulation of cholesterol transport (GO:0032375)4.48941393
60negative regulation of coagulation (GO:0050819)4.47334614
61plasma lipoprotein particle remodeling (GO:0034369)4.45753951
62protein-lipid complex remodeling (GO:0034368)4.45753951
63macromolecular complex remodeling (GO:0034367)4.45753951
64triglyceride homeostasis (GO:0070328)4.42173680
65acylglycerol homeostasis (GO:0055090)4.42173680
66negative regulation of wound healing (GO:0061045)4.42026917
67indolalkylamine metabolic process (GO:0006586)4.40849791
68serine family amino acid metabolic process (GO:0009069)4.38472420
69acute-phase response (GO:0006953)4.38079806
70cellular amino acid catabolic process (GO:0009063)4.37344001
71glutamate metabolic process (GO:0006536)4.35802023
72glycine metabolic process (GO:0006544)4.33677229
73regulation of humoral immune response (GO:0002920)4.32527744
74cellular glucuronidation (GO:0052695)4.30178497
75cellular biogenic amine catabolic process (GO:0042402)4.28395644
76amine catabolic process (GO:0009310)4.28395644
77drug transmembrane transport (GO:0006855)4.27985571
78coenzyme catabolic process (GO:0009109)4.27981476
79phospholipid efflux (GO:0033700)4.27671761
80cellular modified amino acid catabolic process (GO:0042219)4.26748943
81urate metabolic process (GO:0046415)4.26530152
82positive regulation of hemostasis (GO:1900048)4.25590938
83positive regulation of blood coagulation (GO:0030194)4.25590938
84negative regulation of protein activation cascade (GO:2000258)4.25493518
85bile acid and bile salt transport (GO:0015721)4.23729391
86benzene-containing compound metabolic process (GO:0042537)4.20027110
87serine family amino acid biosynthetic process (GO:0009070)4.13925814
88opsonization (GO:0008228)4.13281060
89fat-soluble vitamin biosynthetic process (GO:0042362)4.10615670
90plasma lipoprotein particle clearance (GO:0034381)4.09524665
91heme transport (GO:0015886)4.08473566
92imidazole-containing compound metabolic process (GO:0052803)4.07870977
93negative regulation of lipase activity (GO:0060192)4.07572196
94dicarboxylic acid biosynthetic process (GO:0043650)4.04064703
95ethanol oxidation (GO:0006069)4.03073455
96aldehyde catabolic process (GO:0046185)4.01965908
97exogenous drug catabolic process (GO:0042738)3.99375065
98short-chain fatty acid metabolic process (GO:0046459)3.99036966
99ketone body metabolic process (GO:1902224)3.98660174
100cholesterol efflux (GO:0033344)3.96530581
101positive regulation of coagulation (GO:0050820)3.91984325
102arginine metabolic process (GO:0006525)3.91848765
103daunorubicin metabolic process (GO:0044597)3.91182675
104polyketide metabolic process (GO:0030638)3.91182675
105doxorubicin metabolic process (GO:0044598)3.91182675
106cytolysis (GO:0019835)3.90694500
107disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.88859993
108killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.88859993
109glucuronate metabolic process (GO:0019585)3.88339241
110uronic acid metabolic process (GO:0006063)3.88339241
111intestinal cholesterol absorption (GO:0030299)3.86555680
112organic acid catabolic process (GO:0016054)3.86481093
113carboxylic acid catabolic process (GO:0046395)3.86481093
114aspartate family amino acid catabolic process (GO:0009068)3.80154845
115regulation of bile acid biosynthetic process (GO:0070857)3.77687717
116plasma lipoprotein particle assembly (GO:0034377)3.77160850
117regulation of lipoprotein particle clearance (GO:0010984)3.76758232
118low-density lipoprotein particle remodeling (GO:0034374)3.72516513
119fibrinolysis (GO:0042730)3.72307401
120regulation of cholesterol homeostasis (GO:2000188)3.70823149
121response to mercury ion (GO:0046689)3.70566363
122cholesterol homeostasis (GO:0042632)3.66894266
123positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65468178
1242-oxoglutarate metabolic process (GO:0006103)3.65071127
125flavonoid metabolic process (GO:0009812)3.64686200
126phospholipid homeostasis (GO:0055091)3.64477491
127cofactor catabolic process (GO:0051187)3.63041488
128carnitine metabolic process (GO:0009437)3.62779305
129sterol homeostasis (GO:0055092)3.62633056
130fatty acid beta-oxidation (GO:0006635)3.61843887
131positive regulation of triglyceride lipase activity (GO:0061365)3.61831308
132positive regulation of lipoprotein lipase activity (GO:0051006)3.61831308
133positive regulation of lipid catabolic process (GO:0050996)3.61580836
134fatty acid oxidation (GO:0019395)3.61150123
135drug metabolic process (GO:0017144)3.61067845
136monocarboxylic acid catabolic process (GO:0072329)3.60800673
137xenobiotic metabolic process (GO:0006805)3.59261297
138steroid catabolic process (GO:0006706)3.58262190
139negative regulation of fatty acid biosynthetic process (GO:0045717)3.56977126
140very-low-density lipoprotein particle assembly (GO:0034379)3.55489706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34388486
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13875424
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.76663838
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47216083
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16707699
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84454978
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.83397863
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00189670
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85911918
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12168274
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11941074
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08268161
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7397980
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62887551
15CLOCK_20551151_ChIP-Seq_293T_Human1.60755780
16* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46927323
17HTT_18923047_ChIP-ChIP_STHdh_Human1.40019880
18GATA1_22025678_ChIP-Seq_K562_Human1.36056209
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25204710
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.17135991
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17007130
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15143185
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07682070
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06214124
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03319874
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03312334
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01404968
28CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00459648
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99676312
30HNFA_21074721_ChIP-Seq_CACO-2_Human0.98955735
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95731394
32RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94646879
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93731948
34IRF1_19129219_ChIP-ChIP_H3396_Human0.93021493
35PHF8_20622853_ChIP-Seq_HELA_Human0.92948024
36GATA4_25053715_ChIP-Seq_YYC3_Human0.91806171
37PIAS1_25552417_ChIP-Seq_VCAP_Human0.91411077
38ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86936285
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86462216
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86239172
41NFYA_21822215_ChIP-Seq_K562_Human0.84769889
42TP53_18474530_ChIP-ChIP_U2OS_Human0.84320139
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81373330
44IRF8_22096565_ChIP-ChIP_GC-B_Human0.80613996
45ESR2_21235772_ChIP-Seq_MCF-7_Human0.80203420
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79815845
47GATA6_21074721_ChIP-Seq_CACO-2_Human0.79183831
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77077786
49NFE2_27457419_Chip-Seq_LIVER_Mouse0.76726703
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76233339
51SOX2_21211035_ChIP-Seq_LN229_Human0.74842053
52SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74707993
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73359497
54ER_23166858_ChIP-Seq_MCF-7_Human0.72748385
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72438262
56EZH2_27294783_Chip-Seq_NPCs_Mouse0.71639037
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71009229
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70305676
59CBX2_22325352_ChIP-Seq_293T-Rex_Human0.70296776
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70294821
61RARA_24833708_ChIP-Seq_LIVER_Mouse0.70109002
62ESR1_21235772_ChIP-Seq_MCF-7_Human0.69931489
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69754669
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68963874
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66609354
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66609354
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66564369
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66257297
69ZNF263_19887448_ChIP-Seq_K562_Human0.66140850
70CDX2_20551321_ChIP-Seq_CACO-2_Human0.65797534
71ETV1_20927104_ChIP-Seq_GIST48_Human0.64451866
72RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63523829
73IGF1R_20145208_ChIP-Seq_DFB_Human0.63430708
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62726431
75EGR1_19032775_ChIP-ChIP_M12_Human0.61969472
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61893071
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.61737062
78ETV2_25802403_ChIP-Seq_MESCs_Mouse0.61568845
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.61229915
80NFYB_21822215_ChIP-Seq_K562_Human0.60572270
81CEBPB_22108803_ChIP-Seq_LS180_Human0.60156153
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.58928611
83LXR_22292898_ChIP-Seq_THP-1_Human0.58874967
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58085227
85RARB_24833708_ChIP-Seq_LIVER_Mouse0.58007326
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.56670485
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55962231
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.55601757
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.55420193
90MYC_19915707_ChIP-ChIP_AK7_Human0.54872066
91ERG_20517297_ChIP-Seq_VCAP_Human0.54272975
92AR_20517297_ChIP-Seq_VCAP_Human0.54079803
93RBPJ_21746931_ChIP-Seq_IB4_Human0.53850251
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.53032494
95SPI1_20517297_ChIP-Seq_HL60_Human0.52113017
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52027257
97RAC3_21632823_ChIP-Seq_H3396_Human0.51732828
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.51721225
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.51391916
100STAT1_17558387_ChIP-Seq_HELA_Human0.51318412
101CBP_21632823_ChIP-Seq_H3396_Human0.51002233
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.49966566
103OCT4_21477851_ChIP-Seq_ESCs_Mouse0.49693318
104GATA6_25053715_ChIP-Seq_YYC3_Human0.49163333
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.49153774
106* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.49016898
107NCOR_22424771_ChIP-Seq_293T_Human0.48714475
108MYC_19829295_ChIP-Seq_ESCs_Human0.48676505
109CBP_20019798_ChIP-Seq_JUKART_Human0.48368892
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.48368892
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47760428
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47389734
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45556778
114P53_21459846_ChIP-Seq_SAOS-2_Human0.45357935
115TAF2_19829295_ChIP-Seq_ESCs_Human0.44494197
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44158566
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44061025
118GATA2_19941826_ChIP-Seq_K562_Human0.44007167
119TAF15_26573619_Chip-Seq_HEK293_Human0.43696431
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.41857469
121GATA1_19941826_ChIP-Seq_K562_Human0.41734052
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.41724796
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41543681
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.40868821
125CDX2_22108803_ChIP-Seq_LS180_Human0.40602827
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40359688
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40030684
128BCAT_22108803_ChIP-Seq_LS180_Human0.39784071
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.39592484
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39336827
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.39297740
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39118880
133SOX2_20726797_ChIP-Seq_SW620_Human0.38284168
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38129399
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37512840
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.37336207
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37009907
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.36745830
139LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36744651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29343064
2MP0005360_urolithiasis7.88043656
3MP0005085_abnormal_gallbladder_physiolo6.27100632
4MP0005365_abnormal_bile_salt6.00598523
5MP0008875_abnormal_xenobiotic_pharmacok5.16795549
6MP0003806_abnormal_nucleotide_metabolis4.03324571
7MP0003252_abnormal_bile_duct4.00629013
8MP0010329_abnormal_lipoprotein_level3.39463985
9MP0005332_abnormal_amino_acid3.09277529
10MP0009840_abnormal_foam_cell3.03072846
11MP0003195_calcinosis3.00505646
12MP0005083_abnormal_biliary_tract2.81887172
13MP0001666_abnormal_nutrient_absorption2.60935402
14MP0004019_abnormal_vitamin_homeostasis2.55539520
15MP0002138_abnormal_hepatobiliary_system2.31350111
16MP0003191_abnormal_cellular_cholesterol2.16452503
17MP0000609_abnormal_liver_physiology2.07467811
18MP0002118_abnormal_lipid_homeostasis2.04903193
19MP0005319_abnormal_enzyme/_coenzyme1.84065860
20MP0003868_abnormal_feces_composition1.77765282
21MP0001764_abnormal_homeostasis1.65852024
22MP0005584_abnormal_enzyme/coenzyme_acti1.62141844
23MP0005451_abnormal_body_composition1.59196889
24MP0009643_abnormal_urine_homeostasis1.56642655
25MP0009697_abnormal_copulation1.38673264
26MP0003186_abnormal_redox_activity1.34913092
27MP0003011_delayed_dark_adaptation1.21853709
28MP0005636_abnormal_mineral_homeostasis1.17723729
29MP0000598_abnormal_liver_morphology1.14090187
30MP0003656_abnormal_erythrocyte_physiolo1.11473767
31MP0002132_abnormal_respiratory_system1.07649508
32MP0003705_abnormal_hypodermis_morpholog1.05065419
33MP0009764_decreased_sensitivity_to1.04927192
34MP0005647_abnormal_sex_gland1.02865783
35MP0000604_amyloidosis0.97649260
36MP0009763_increased_sensitivity_to0.92856463
37MP0005084_abnormal_gallbladder_morpholo0.91394332
38MP0002254_reproductive_system_inflammat0.90184324
39MP0005670_abnormal_white_adipose0.89162553
40MP0005187_abnormal_penis_morphology0.88421293
41MP0001756_abnormal_urination0.88163894
42MP0009642_abnormal_blood_homeostasis0.88077647
43MP0002876_abnormal_thyroid_physiology0.88059545
44MP0006036_abnormal_mitochondrial_physio0.87955199
45MP0001915_intracranial_hemorrhage0.86582996
46MP0008469_abnormal_protein_level0.86385926
47MP0004043_abnormal_pH_regulation0.83428064
48MP0005408_hypopigmentation0.81058444
49MP0005376_homeostasis/metabolism_phenot0.76813682
50MP0002078_abnormal_glucose_homeostasis0.76663616
51MP0010368_abnormal_lymphatic_system0.76204094
52MP0009765_abnormal_xenobiotic_induced0.75657108
53MP0002136_abnormal_kidney_physiology0.74651371
54MP0005535_abnormal_body_temperature0.72500010
55MP0005220_abnormal_exocrine_pancreas0.71818296
56MP0002282_abnormal_trachea_morphology0.71225196
57MP0001661_extended_life_span0.69508687
58MP0002971_abnormal_brown_adipose0.69101531
59MP0005334_abnormal_fat_pad0.64855122
60MP0005266_abnormal_metabolism0.63385056
61MP0003879_abnormal_hair_cell0.63252788
62MP0004130_abnormal_muscle_cell0.63051343
63MP0003329_amyloid_beta_deposits0.60337906
64MP0003690_abnormal_glial_cell0.60011784
65MP0009053_abnormal_anal_canal0.59919734
66MP0006035_abnormal_mitochondrial_morpho0.59656765
67MP0002928_abnormal_bile_duct0.58855277
68MP0001765_abnormal_ion_homeostasis0.54882554
69MP0003638_abnormal_response/metabolism_0.52577801
70MP0002249_abnormal_larynx_morphology0.51251741
71MP0005395_other_phenotype0.50822302
72MP0005448_abnormal_energy_balance0.50184690
73MP0000639_abnormal_adrenal_gland0.48711013
74MP0005023_abnormal_wound_healing0.48579294
75MP0005666_abnormal_adipose_tissue0.46659585
76MP0000230_abnormal_systemic_arterial0.44023166
77MP0008874_decreased_physiological_sensi0.43659353
78MP0005464_abnormal_platelet_physiology0.42564360
79MP0003953_abnormal_hormone_level0.42242655
80MP0005058_abnormal_lysosome_morphology0.41697079
81MP0002822_catalepsy0.41635673
82MP0002168_other_aberrant_phenotype0.41405512
83MP0008873_increased_physiological_sensi0.40991467
84MP0003718_maternal_effect0.40156529
85MP0003724_increased_susceptibility_to0.39313063
86MP0003959_abnormal_lean_body0.39223812
87MP0008872_abnormal_physiological_respon0.38139754
88MP0009785_altered_susceptibility_to0.38116600
89MP0004782_abnormal_surfactant_physiolog0.37209808
90MP0002796_impaired_skin_barrier0.36951363
91MP0009672_abnormal_birth_weight0.36394830
92MP0003075_altered_response_to0.36206912
93MP0005166_decreased_susceptibility_to0.35937164
94MP0002837_dystrophic_cardiac_calcinosis0.35701264
95MP0002332_abnormal_exercise_endurance0.34067046
96MP0003436_decreased_susceptibility_to0.31627272
97MP0009115_abnormal_fat_cell0.31463913
98MP0004883_abnormal_blood_vessel0.31398591
99MP0005164_abnormal_response_to0.31073233
100MP0005248_abnormal_Harderian_gland0.30909228
101MP0002135_abnormal_kidney_morphology0.30780080
102MP0000538_abnormal_urinary_bladder0.30664403
103MP0005197_abnormal_uvea_morphology0.30481836
104MP0009384_cardiac_valve_regurgitation0.30393183
105MP0000467_abnormal_esophagus_morphology0.30244277
106MP0004264_abnormal_extraembryonic_tissu0.29424678
107MP0006082_CNS_inflammation0.28617507
108MP0003300_gastrointestinal_ulcer0.28166239
109MP0000579_abnormal_nail_morphology0.27598204
110MP0001845_abnormal_inflammatory_respons0.27165573
111MP0004381_abnormal_hair_follicle0.26492705
112MP0000249_abnormal_blood_vessel0.26400179
113MP0002970_abnormal_white_adipose0.26334881
114MP0001853_heart_inflammation0.25239198
115MP0004142_abnormal_muscle_tone0.19930555
116MP0001851_eye_inflammation0.19508406
117MP0000566_synostosis0.19299399
118MP0001881_abnormal_mammary_gland0.18776472
119MP0002128_abnormal_blood_circulation0.17681039
120MP0004272_abnormal_basement_membrane0.15693214
121MP0003633_abnormal_nervous_system0.13174803
122MP0003632_abnormal_nervous_system0.11262027

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14576937
2Intrahepatic cholestasis (HP:0001406)6.98614198
3Deep venous thrombosis (HP:0002625)6.77980749
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37497864
5Xanthomatosis (HP:0000991)6.10588129
6Hypobetalipoproteinemia (HP:0003563)6.04174961
7Prolonged partial thromboplastin time (HP:0003645)5.91455655
8Hyperlipoproteinemia (HP:0010980)5.12767825
9Complement deficiency (HP:0004431)4.74815127
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.68527863
11Hyperammonemia (HP:0001987)4.67138764
12Hyperglycinemia (HP:0002154)4.49418840
13Ketosis (HP:0001946)4.49412512
14Hypolipoproteinemia (HP:0010981)4.47603270
15Joint hemorrhage (HP:0005261)4.42079625
16Hyperglycinuria (HP:0003108)4.41701881
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.36464594
18Epidermoid cyst (HP:0200040)4.32985817
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.30919162
20Abnormality of serine family amino acid metabolism (HP:0010894)4.25912198
21Abnormality of glycine metabolism (HP:0010895)4.25912198
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.08905888
23Abnormality of methionine metabolism (HP:0010901)4.08368344
24Abnormality of the common coagulation pathway (HP:0010990)4.02826064
25Fat malabsorption (HP:0002630)3.99002900
26Hypoalphalipoproteinemia (HP:0003233)3.86171431
27Hypoglycemic coma (HP:0001325)3.77623289
28Abnormality of pyrimidine metabolism (HP:0004353)3.74236042
29Nephritis (HP:0000123)3.71596428
30Conjugated hyperbilirubinemia (HP:0002908)3.63712780
31Abnormality of fatty-acid metabolism (HP:0004359)3.58718777
32Hypercholesterolemia (HP:0003124)3.43618725
33Abnormality of complement system (HP:0005339)3.42442768
34Abnormality of nucleobase metabolism (HP:0010932)3.40857568
35Abnormality of the intrinsic pathway (HP:0010989)3.40719137
36Ketoacidosis (HP:0001993)3.39779479
37Gout (HP:0001997)3.39081179
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33118093
39Delayed CNS myelination (HP:0002188)3.31332398
40Hyperbilirubinemia (HP:0002904)3.25666525
41Abnormality of purine metabolism (HP:0004352)3.24168331
42Abnormality of serum amino acid levels (HP:0003112)3.11575934
43Hepatocellular carcinoma (HP:0001402)2.97976174
44Metabolic acidosis (HP:0001942)2.96768711
45Steatorrhea (HP:0002570)2.93379761
46Reduced antithrombin III activity (HP:0001976)2.85658464
47Vascular calcification (HP:0004934)2.83667242
48Dicarboxylic aciduria (HP:0003215)2.78399464
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78399464
50Osteomalacia (HP:0002749)2.77903022
51Lethargy (HP:0001254)2.73924268
52Myocardial infarction (HP:0001658)2.68133954
53Fair hair (HP:0002286)2.64982418
54Skin nodule (HP:0200036)2.63479166
55Spontaneous abortion (HP:0005268)2.62274585
56Hypochromic microcytic anemia (HP:0004840)2.58610206
57Generalized aminoaciduria (HP:0002909)2.56870605
58Neonatal hypoglycemia (HP:0001998)2.56254207
59Malnutrition (HP:0004395)2.55700158
60Spastic diplegia (HP:0001264)2.51562892
61Cardiovascular calcification (HP:0011915)2.51349392
62Proximal tubulopathy (HP:0000114)2.50387253
63Systemic lupus erythematosus (HP:0002725)2.49550701
64Irritability (HP:0000737)2.46332519
65Acanthocytosis (HP:0001927)2.45997493
66Alkalosis (HP:0001948)2.45966753
67Cerebral edema (HP:0002181)2.42779933
68Pulmonary embolism (HP:0002204)2.41365098
69Purpura (HP:0000979)2.41155173
70Neonatal onset (HP:0003623)2.40829354
71Hyperuricemia (HP:0002149)2.36881220
72Increased purine levels (HP:0004368)2.36881220
73Enlarged kidneys (HP:0000105)2.33913975
74Hypoglycemic seizures (HP:0002173)2.33463365
75Abnormal gallbladder morphology (HP:0012437)2.29775074
76Sensorimotor neuropathy (HP:0007141)2.29328407
77Hydroxyprolinuria (HP:0003080)2.27582877
78Abnormality of proline metabolism (HP:0010907)2.27582877
79Vomiting (HP:0002013)2.27506483
80Mitral stenosis (HP:0001718)2.25343696
81Cholelithiasis (HP:0001081)2.24859622
82Cholecystitis (HP:0001082)2.24733132
83Abnormal gallbladder physiology (HP:0012438)2.24733132
84Hyperphosphaturia (HP:0003109)2.24228180
85Rickets (HP:0002748)2.23348871
86Late onset (HP:0003584)2.21280701
87Abnormality of urine glucose concentration (HP:0011016)2.19807286
88Glycosuria (HP:0003076)2.19807286
89Glomerulonephritis (HP:0000099)2.19595692
90Pancreatitis (HP:0001733)2.17766636
91Esophageal varix (HP:0002040)2.10515386
92Elevated alkaline phosphatase (HP:0003155)2.09881081
93Brushfield spots (HP:0001088)2.05029843
94Abnormal enzyme/coenzyme activity (HP:0012379)2.03677804
95Amyloidosis (HP:0011034)1.99542149
96Opisthotonus (HP:0002179)1.98787501
97Recurrent gram-negative bacterial infections (HP:0005420)1.97528014
98Menorrhagia (HP:0000132)1.95254912
99Abnormal biliary tract physiology (HP:0012439)1.95180130
100Bile duct proliferation (HP:0001408)1.95180130
101Hypophosphatemic rickets (HP:0004912)1.93152493
102Thrombophlebitis (HP:0004418)1.92477127
103Abnormality of the gallbladder (HP:0005264)1.91307732
104Abnormal cartilage morphology (HP:0002763)1.89896278
105Hyperinsulinemic hypoglycemia (HP:0000825)1.89274380
106Poikilocytosis (HP:0004447)1.88560856
107Arthropathy (HP:0003040)1.88289346
108Abnormality of alkaline phosphatase activity (HP:0004379)1.88179787
109Bifid scrotum (HP:0000048)1.87281572
110Renal cortical cysts (HP:0000803)1.86534024
111Gingival bleeding (HP:0000225)1.86334573
112Hemorrhage of the eye (HP:0011885)1.84924522
113Increased mean platelet volume (HP:0011877)1.84578361
114Confusion (HP:0001289)1.84029682
115Generalized hypopigmentation of hair (HP:0011358)1.82937041
116Abnormality of vitamin metabolism (HP:0100508)1.81332894
117Gangrene (HP:0100758)1.78785582
118Abnormal urine phosphate concentration (HP:0012599)1.78520411
119Atrioventricular block (HP:0001678)1.76164738
120Abnormality of the Achilles tendon (HP:0005109)1.75723111
121Abnormality of iron homeostasis (HP:0011031)1.71182514
122Joint swelling (HP:0001386)1.70760187
123Increased serum ferritin (HP:0003281)1.66389746
124Abnormal platelet volume (HP:0011876)1.65891794
125Reticulocytosis (HP:0001923)1.59705959
126Cerebral palsy (HP:0100021)1.58269017
127Blue irides (HP:0000635)1.55013191
128Abnormality of transition element cation homeostasis (HP:0011030)1.54861960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.23908020
2FGFR44.30554708
3SIK14.12240756
4ERN13.94345032
5INSRR2.92978947
6ERBB42.71770224
7TAOK32.65781180
8MST1R2.40146371
9MAP2K42.20990348
10PKN22.05327086
11MAP3K122.00976124
12MAPK111.86596277
13WNK41.81749022
14PIK3CA1.77395786
15WNK31.75510633
16PIK3CG1.73236867
17FLT31.67929611
18LATS11.67158436
19NTRK31.66304011
20TRIB31.57468927
21FRK1.56557364
22PRPF4B1.55617463
23STK38L1.53225224
24TYK21.50530151
25ABL21.49540077
26MYLK1.47375285
27PTK61.45120372
28OXSR11.40629343
29DAPK21.32620340
30MAP3K71.32150992
31NEK91.32016833
32PINK11.29828042
33GRK61.23801100
34ARAF1.23713406
35FGFR21.23000354
36TNK21.19557450
37KDR1.16893337
38PRKAA21.16680081
39JAK21.12066249
40MAP3K31.04796037
41MAP3K101.04175285
42MAP2K31.02345590
43MAP3K141.00763506
44FER0.99431958
45CASK0.95324030
46PRKCZ0.93151451
47ERBB20.92859065
48MUSK0.92441344
49EPHB10.92106183
50MAPK40.91909794
51MAP3K10.91907996
52TBK10.91410695
53EIF2AK10.90521066
54SCYL20.89144107
55MET0.89076289
56PRKACA0.88910613
57KSR20.87543314
58JAK10.87523346
59MAP3K20.87222460
60SGK30.86987285
61NLK0.85174323
62PRKG10.83588047
63PDK40.82620720
64PDK30.82620720
65MAP3K90.82270377
66GSK3A0.80734962
67TIE10.80575087
68MAPK150.79076208
69DYRK1B0.78093513
70SGK2230.76775084
71SGK4940.76775084
72PRKAA10.75497921
73CSNK1D0.75292292
74PRKACG0.73765386
75MAPK120.72818423
76BCR0.72108301
77SGK20.68993535
78MAP3K110.68688714
79CDK60.68208140
80MAP2K60.66497446
81PTK20.64567105
82CSK0.64207446
83RIPK10.64151508
84IRAK30.64121481
85CAMKK20.61608293
86CAMK2G0.61480809
87TGFBR20.59464580
88PDPK10.58897803
89PRKCB0.55076022
90RPS6KA30.54834551
91EPHA30.54271453
92CAMK1D0.53310839
93PRKACB0.50417859
94EPHA40.49374551
95PRKCQ0.48467648
96FGFR30.48102132
97MAPK70.48092774
98CAMKK10.46274758
99CSNK1G10.44202352
100CSF1R0.43119799
101NEK10.42406920
102MAP3K50.41622514
103IGF1R0.40862762
104SGK10.40643302
105IKBKE0.40173530
106SRC0.39733833
107CSNK1E0.39488086
108PDK20.39247406
109GRK10.38621202
110PDK10.38197581
111MAP3K60.37029795
112STK390.36196839
113MAP2K10.35950188
114PRKCG0.35506980
115STK380.35096271
116CSNK2A10.33858432
117MAP3K130.33769707
118RET0.33318665
119MTOR0.32791441
120ICK0.32161707
121TAOK20.31370405
122CDK40.31149378
123IRAK20.30933432
124RAF10.30759753
125AKT30.29859378
126EGFR0.28797827
127ZAP700.28117906
128PRKCA0.27597686
129PAK30.26506948
130PBK0.26191038
131CAMK40.25789841
132PKN10.25714276
133IRAK10.25393551

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.28740525
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46368524
3Nitrogen metabolism_Homo sapiens_hsa009103.41171014
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31114812
5Arginine biosynthesis_Homo sapiens_hsa002202.94527441
6Tryptophan metabolism_Homo sapiens_hsa003802.71730277
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70571071
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69520443
9Fatty acid degradation_Homo sapiens_hsa000712.56308850
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52056620
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51016369
12Complement and coagulation cascades_Homo sapiens_hsa046102.45980273
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40136256
14Butanoate metabolism_Homo sapiens_hsa006502.38572012
15Peroxisome_Homo sapiens_hsa041462.18921128
16Propanoate metabolism_Homo sapiens_hsa006402.08850944
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06728729
18PPAR signaling pathway_Homo sapiens_hsa033201.88132377
19Histidine metabolism_Homo sapiens_hsa003401.87421051
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.86381307
21Fatty acid metabolism_Homo sapiens_hsa012121.85994963
22Chemical carcinogenesis_Homo sapiens_hsa052041.85426201
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83210088
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82481189
25beta-Alanine metabolism_Homo sapiens_hsa004101.79772032
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71724669
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70760714
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69773272
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64719661
30Caffeine metabolism_Homo sapiens_hsa002321.64662087
31Retinol metabolism_Homo sapiens_hsa008301.64023167
32Bile secretion_Homo sapiens_hsa049761.56881451
33Selenocompound metabolism_Homo sapiens_hsa004501.56455107
34Phenylalanine metabolism_Homo sapiens_hsa003601.52560310
35Staphylococcus aureus infection_Homo sapiens_hsa051501.51723005
36Sulfur metabolism_Homo sapiens_hsa009201.41400684
37* Pyruvate metabolism_Homo sapiens_hsa006201.35188649
38Starch and sucrose metabolism_Homo sapiens_hsa005001.34825527
39Tyrosine metabolism_Homo sapiens_hsa003501.33996588
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33662344
41Fatty acid elongation_Homo sapiens_hsa000621.31099310
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28954529
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.28317303
44Folate biosynthesis_Homo sapiens_hsa007901.22201682
45Carbon metabolism_Homo sapiens_hsa012001.20134346
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19764653
47ABC transporters_Homo sapiens_hsa020101.16195979
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15498034
49Fat digestion and absorption_Homo sapiens_hsa049751.14235642
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13502701
51Steroid biosynthesis_Homo sapiens_hsa001001.10918341
52Vitamin digestion and absorption_Homo sapiens_hsa049771.06364795
53Arginine and proline metabolism_Homo sapiens_hsa003301.03826894
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.98665732
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91976787
56Lysine degradation_Homo sapiens_hsa003100.89714506
57Sulfur relay system_Homo sapiens_hsa041220.86743583
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84843452
59Vitamin B6 metabolism_Homo sapiens_hsa007500.80612831
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76549228
61Glutathione metabolism_Homo sapiens_hsa004800.75772692
62Glycerolipid metabolism_Homo sapiens_hsa005610.73983993
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68906503
64One carbon pool by folate_Homo sapiens_hsa006700.66571121
65Pentose phosphate pathway_Homo sapiens_hsa000300.58845006
66Metabolic pathways_Homo sapiens_hsa011000.47953714
67Fatty acid biosynthesis_Homo sapiens_hsa000610.44931291
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34386327
69Fructose and mannose metabolism_Homo sapiens_hsa000510.31875075
70Galactose metabolism_Homo sapiens_hsa000520.28449257
71Pertussis_Homo sapiens_hsa051330.26962488
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24875443
73Prion diseases_Homo sapiens_hsa050200.22898143
74Insulin resistance_Homo sapiens_hsa049310.22212346
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.21373131
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19697220
77Linoleic acid metabolism_Homo sapiens_hsa005910.16298281
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.13178528
79Glucagon signaling pathway_Homo sapiens_hsa049220.09214519
80AMPK signaling pathway_Homo sapiens_hsa041520.02132335
81Serotonergic synapse_Homo sapiens_hsa047260.00902859
82N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2682509
83Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2545848
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2398136
85Sphingolipid metabolism_Homo sapiens_hsa00600-0.2368383
86Lysosome_Homo sapiens_hsa04142-0.2294307
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2294118
88Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2273513
89Circadian rhythm_Homo sapiens_hsa04710-0.2208550
90African trypanosomiasis_Homo sapiens_hsa05143-0.2071070
91Type II diabetes mellitus_Homo sapiens_hsa04930-0.2045842
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1926032
93Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1790170
94Hepatitis C_Homo sapiens_hsa05160-0.1757732
95Regulation of autophagy_Homo sapiens_hsa04140-0.1354035
96Protein digestion and absorption_Homo sapiens_hsa04974-0.1327316
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1286269
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1270423
99Insulin signaling pathway_Homo sapiens_hsa04910-0.1209979
100Mineral absorption_Homo sapiens_hsa04978-0.1110623
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1089443
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0973498
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0939184
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0918749
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0833965
106Other glycan degradation_Homo sapiens_hsa00511-0.0565235
107Amoebiasis_Homo sapiens_hsa05146-0.0500147
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0385714
109Renin-angiotensin system_Homo sapiens_hsa04614-0.0286156

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