ACO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.00935029
2carnitine shuttle (GO:0006853)5.97326208
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.87972771
4NADH metabolic process (GO:0006734)5.70131977
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.64155145
6sarcomere organization (GO:0045214)5.58350320
7regulation of acyl-CoA biosynthetic process (GO:0050812)5.37637554
8cardiac myofibril assembly (GO:0055003)5.36816394
9negative regulation of potassium ion transmembrane transport (GO:1901380)5.30409688
10fatty acid transmembrane transport (GO:1902001)5.27676032
11regulation of coenzyme metabolic process (GO:0051196)5.05226681
12regulation of cofactor metabolic process (GO:0051193)5.05226681
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.84223513
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.75784484
15cardiac muscle contraction (GO:0060048)4.71931898
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.70502632
17myofibril assembly (GO:0030239)4.68978098
18carnitine transmembrane transport (GO:1902603)4.65042450
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.63946699
20plasma membrane repair (GO:0001778)4.58706858
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.55964754
22carnitine transport (GO:0015879)4.53692197
23amino-acid betaine transport (GO:0015838)4.53692197
24lysine catabolic process (GO:0006554)4.52800526
25lysine metabolic process (GO:0006553)4.52800526
26actin-myosin filament sliding (GO:0033275)4.48841534
27muscle filament sliding (GO:0030049)4.48841534
28succinate metabolic process (GO:0006105)4.48679732
29regulation of sequestering of triglyceride (GO:0010889)4.37989772
302-oxoglutarate metabolic process (GO:0006103)4.32559209
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.31678982
32cell communication by electrical coupling (GO:0010644)4.31605694
33regulation of fatty acid oxidation (GO:0046320)4.23845684
34skeletal muscle contraction (GO:0003009)4.23684627
35cell communication involved in cardiac conduction (GO:0086065)4.09993509
36fatty acid beta-oxidation (GO:0006635)4.08804366
37aspartate family amino acid catabolic process (GO:0009068)4.06664137
38ventricular cardiac muscle cell action potential (GO:0086005)4.03627390
39regulation of sulfur metabolic process (GO:0042762)4.00103608
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.99714047
41regulation of actin filament-based movement (GO:1903115)3.98968052
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.95502399
43gluconeogenesis (GO:0006094)3.92188193
44regulation of membrane repolarization (GO:0060306)3.86494372
45cellular potassium ion homeostasis (GO:0030007)3.83804475
46cardiac muscle cell development (GO:0055013)3.75947638
47striated muscle contraction (GO:0006941)3.75862492
48oxaloacetate metabolic process (GO:0006107)3.75492492
49actomyosin structure organization (GO:0031032)3.72113191
50regulation of skeletal muscle contraction (GO:0014819)3.64802476
51actin-mediated cell contraction (GO:0070252)3.63788471
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.61416240
53cardiac muscle hypertrophy (GO:0003300)3.60058652
54quaternary ammonium group transport (GO:0015697)3.58221685
55hexose biosynthetic process (GO:0019319)3.55892919
56regulation of relaxation of muscle (GO:1901077)3.51602394
57cardiac cell development (GO:0055006)3.48951210
58regulation of cell communication by electrical coupling (GO:0010649)3.48671181
59fructose metabolic process (GO:0006000)3.48215845
60biotin metabolic process (GO:0006768)3.47540168
61acetyl-CoA metabolic process (GO:0006084)3.44561028
62striated muscle hypertrophy (GO:0014897)3.43818264
63fatty acid catabolic process (GO:0009062)3.35904344
64fatty acid oxidation (GO:0019395)3.34193083
65regulation of the force of heart contraction (GO:0002026)3.32777890
66adult heart development (GO:0007512)3.30901674
67monosaccharide biosynthetic process (GO:0046364)3.29290879
68lipid oxidation (GO:0034440)3.29027305
69oxidative phosphorylation (GO:0006119)3.28024118
70* tricarboxylic acid metabolic process (GO:0072350)3.26911076
71regulation of striated muscle contraction (GO:0006942)3.26461592
72positive regulation of fatty acid oxidation (GO:0046321)3.24155823
73muscle contraction (GO:0006936)3.22260083
74heart trabecula formation (GO:0060347)3.20867379
75glycolytic process (GO:0006096)3.19195994
76heart process (GO:0003015)3.17430576
77heart contraction (GO:0060047)3.17430576
78branched-chain amino acid catabolic process (GO:0009083)3.16642514
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15968802
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15286336
81bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14925007
82cardiac muscle cell action potential involved in contraction (GO:0086002)3.13913824
83creatine metabolic process (GO:0006600)3.13372487
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12256476
85synaptic vesicle docking involved in exocytosis (GO:0016081)3.11953772
86negative regulation of potassium ion transport (GO:0043267)3.11352628
87regulation of sarcomere organization (GO:0060297)3.10756468
88cardiac muscle tissue morphogenesis (GO:0055008)3.10238065
89cardiac muscle cell action potential (GO:0086001)3.09797022
90respiratory electron transport chain (GO:0022904)3.08979111
91positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07456027
92sodium ion export (GO:0071436)3.06732586
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06182862
94membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05897181
95short-chain fatty acid metabolic process (GO:0046459)3.05616421
96dicarboxylic acid biosynthetic process (GO:0043650)3.04216764
97relaxation of cardiac muscle (GO:0055119)3.03952462
98intracellular lipid transport (GO:0032365)3.01599549
99cellular response to epinephrine stimulus (GO:0071872)3.01454466
100branched-chain amino acid metabolic process (GO:0009081)3.00743589
101detection of calcium ion (GO:0005513)3.00712442
102electron transport chain (GO:0022900)2.99619574
103activation of protein kinase A activity (GO:0034199)2.98599849
104striated muscle adaptation (GO:0014888)2.96793479
105muscle hypertrophy (GO:0014896)2.96688638
106skeletal muscle adaptation (GO:0043501)2.96687858
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.95695290
108cardiac conduction (GO:0061337)2.95690221
109ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.93726186
110regulation of calcium ion transmembrane transporter activity (GO:1901019)2.93230043
111regulation of calcium ion transmembrane transport (GO:1903169)2.93230043
112regulation of cardiac muscle cell contraction (GO:0086004)2.92627306
113potassium ion import (GO:0010107)2.92295188
114synaptic vesicle maturation (GO:0016188)2.91760825
115positive regulation of fatty acid beta-oxidation (GO:0032000)2.89652398
116muscle system process (GO:0003012)2.88628893
117valine metabolic process (GO:0006573)2.88565520
118muscle tissue morphogenesis (GO:0060415)2.88428185
119muscle hypertrophy in response to stress (GO:0003299)2.87903942
120cardiac muscle adaptation (GO:0014887)2.87903942
121cardiac muscle hypertrophy in response to stress (GO:0014898)2.87903942
122actin filament-based movement (GO:0030048)2.87182280
123response to inactivity (GO:0014854)2.86093603
124synaptic vesicle exocytosis (GO:0016079)2.86020687
125positive regulation of synapse maturation (GO:0090129)2.85834531
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.85546583
127response to epinephrine (GO:0071871)2.83600521
128regulation of synaptic vesicle exocytosis (GO:2000300)2.80385809
129cellular sodium ion homeostasis (GO:0006883)2.79907398
130glutamate secretion (GO:0014047)2.78965673
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73614089
132potassium ion homeostasis (GO:0055075)2.71833173
133regulation of ATP catabolic process (GO:1903289)2.69786812
134regulation of ATPase activity (GO:0043462)2.69786812
135Golgi transport vesicle coating (GO:0048200)2.69485608
136COPI coating of Golgi vesicle (GO:0048205)2.69485608
137glycogen catabolic process (GO:0005980)2.68458471
138glucan catabolic process (GO:0009251)2.66816957
139cGMP-mediated signaling (GO:0019934)2.66224049
140response to muscle activity (GO:0014850)2.66129912
141response to mercury ion (GO:0046689)2.58546740
142fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57946880
143regulation of heart contraction (GO:0008016)2.55476660
144negative regulation of calcium ion transmembrane transport (GO:1903170)2.54433747
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54433747
146pyruvate metabolic process (GO:0006090)2.54365407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.08587430
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.03877559
3* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.82745336
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.76581601
5ZNF263_19887448_ChIP-Seq_K562_Human2.72254959
6TBX20_22328084_ChIP-Seq_HEART_Mouse2.47077425
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.47077425
8EZH2_22144423_ChIP-Seq_EOC_Human2.45211163
9* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41149248
10CLOCK_20551151_ChIP-Seq_293T_Human2.25226283
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.14028616
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.13155838
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06966606
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03348319
15DROSHA_22980978_ChIP-Seq_HELA_Human2.02446772
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.93566974
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87086114
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.79571215
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76450891
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70561304
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67901703
22* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66687735
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63832850
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63545883
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.62852818
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.62535476
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60099446
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59120034
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56412662
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.55689718
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54682496
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53844850
33SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52937516
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52410466
35VDR_21846776_ChIP-Seq_THP-1_Human1.49414798
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.49353600
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47751910
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45037156
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.44829820
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44094495
41* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43895871
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.41555124
43LXR_22292898_ChIP-Seq_THP-1_Human1.41068384
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40888023
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40563508
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39870456
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38909458
48TCF7_22412390_ChIP-Seq_EML_Mouse1.38208496
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36795445
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34855750
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34855750
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33819294
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31074574
54KDM2B_26808549_Chip-Seq_K562_Human1.30619384
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30087159
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29901345
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.28494077
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27526563
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27179354
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24896156
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23442447
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23006446
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22875288
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22398547
65KDM2B_26808549_Chip-Seq_DND41_Human1.21988617
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21802104
67RACK7_27058665_Chip-Seq_MCF-7_Human1.18100273
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17730462
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16880284
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16801814
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.16797802
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15758350
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14897960
74CTCF_27219007_Chip-Seq_Bcells_Human1.14116515
75SA1_27219007_Chip-Seq_Bcells_Human1.13169956
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13158709
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12974382
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12739383
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11658518
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.11522812
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.11199047
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10951616
83P68_20966046_ChIP-Seq_HELA_Human1.08528025
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07499705
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07438264
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.07321604
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06445519
88* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06136892
89GATA1_19941826_ChIP-Seq_K562_Human1.05699184
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.05603736
91TP63_22573176_ChIP-Seq_HFKS_Human1.04949699
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04521950
93CREB1_26743006_Chip-Seq_LNCaP_Human1.02958609
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02728150
95SMC4_20622854_ChIP-Seq_HELA_Human1.02671574
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01647944
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01585544
98ZNF274_21170338_ChIP-Seq_K562_Hela1.00296666
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00189671
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99580994
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98898750
102* BCOR_27268052_Chip-Seq_Bcells_Human0.98702068
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98054665
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97938414
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97681295
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97418851
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97382276
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97349860
109MYC_22102868_ChIP-Seq_BL_Human0.97218669
110* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96814530
111* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96215556
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.95804823
113ATF3_27146783_Chip-Seq_COLON_Human0.95603308
114* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94859578
115ETS1_21867929_ChIP-Seq_TH2_Mouse0.94778807
116JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94742762
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94359690
118* ELF1_20517297_ChIP-Seq_JURKAT_Human0.93619497
119SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93277191
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.93190447
121KLF4_19829295_ChIP-Seq_ESCs_Human0.92239820
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91035138
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90839660
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90805657
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90789819
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90507882
127* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90012761
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89455935
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89451538
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.88911058
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88357110
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.87679871
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.86980128
134REST_21632747_ChIP-Seq_MESCs_Mouse0.86862078
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83547625
136AR_19668381_ChIP-Seq_PC3_Human0.83017954
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82711006
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81685857
139JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81251167
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.79685707
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79636063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.67855396
2MP0003646_muscle_fatigue4.94421031
3MP0004084_abnormal_cardiac_muscle4.45582565
4MP0000751_myopathy4.40323623
5MP0004215_abnormal_myocardial_fiber3.81800405
6MP0004036_abnormal_muscle_relaxation3.50895008
7MP0004130_abnormal_muscle_cell3.40187188
8MP0005330_cardiomyopathy3.24631208
9MP0005451_abnormal_body_composition3.17323345
10MP0000749_muscle_degeneration3.12657514
11MP0004087_abnormal_muscle_fiber2.72350751
12MP0002972_abnormal_cardiac_muscle2.54750684
13MP0005670_abnormal_white_adipose2.50035378
14MP0005666_abnormal_adipose_tissue2.43200690
15MP0008775_abnormal_heart_ventricle2.42591282
16MP0005620_abnormal_muscle_contractility2.39043445
17MP0003137_abnormal_impulse_conducting2.31932380
18MP0000750_abnormal_muscle_regeneration2.16353899
19MP0002269_muscular_atrophy2.15211465
20MP0001544_abnormal_cardiovascular_syste2.11470869
21MP0005385_cardiovascular_system_phenoty2.11470869
22MP0000747_muscle_weakness2.10157613
23MP0002106_abnormal_muscle_physiology2.09301021
24MP0004145_abnormal_muscle_electrophysio2.08708522
25MP0006138_congestive_heart_failure2.08558622
26MP0004233_abnormal_muscle_weight2.06543518
27MP0004484_altered_response_of2.02397602
28MP0010630_abnormal_cardiac_muscle2.02246982
29MP0006036_abnormal_mitochondrial_physio1.99622110
30MP0004043_abnormal_pH_regulation1.84011293
31MP0000759_abnormal_skeletal_muscle1.79794112
32MP0004185_abnormal_adipocyte_glucose1.79742458
33MP0004085_abnormal_heartbeat1.79242304
34MP0005375_adipose_tissue_phenotype1.75567811
35MP0003221_abnormal_cardiomyocyte_apopto1.75490662
36MP0004859_abnormal_synaptic_plasticity1.73915927
37MP0005369_muscle_phenotype1.70027113
38MP0000013_abnormal_adipose_tissue1.62885295
39MP0005058_abnormal_lysosome_morphology1.58788727
40MP0003879_abnormal_hair_cell1.56285461
41MP0009780_abnormal_chondrocyte_physiolo1.45333768
42MP0002971_abnormal_brown_adipose1.44998895
43MP0002909_abnormal_adrenal_gland1.44540989
44MP0005423_abnormal_somatic_nervous1.37688189
45MP0000003_abnormal_adipose_tissue1.37318915
46MP0008260_abnormal_autophagy1.36772916
47MP0002332_abnormal_exercise_endurance1.31823041
48MP0008961_abnormal_basal_metabolism1.31517118
49MP0002822_catalepsy1.24920852
50MP0003705_abnormal_hypodermis_morpholog1.23092672
51MP0005535_abnormal_body_temperature1.19656170
52MP0000604_amyloidosis1.17570702
53MP0003828_pulmonary_edema1.17303243
54MP0006035_abnormal_mitochondrial_morpho1.12634034
55MP0004510_myositis1.08637855
56MP0005332_abnormal_amino_acid1.08375515
57MP0000920_abnormal_myelination1.07570306
58MP0003075_altered_response_to1.07190440
59MP0003329_amyloid_beta_deposits1.03403876
60MP0002734_abnormal_mechanical_nocicepti1.01684419
61MP0002078_abnormal_glucose_homeostasis0.97102035
62MP0005166_decreased_susceptibility_to0.96777360
63MP0002127_abnormal_cardiovascular_syste0.94419956
64MP0005409_darkened_coat_color0.93874572
65MP0008874_decreased_physiological_sensi0.93534699
66MP0000230_abnormal_systemic_arterial0.91763321
67MP0002234_abnormal_pharynx_morphology0.90801892
68MP0003635_abnormal_synaptic_transmissio0.90653226
69MP0002118_abnormal_lipid_homeostasis0.90306829
70MP0003634_abnormal_glial_cell0.90050210
71MP0004858_abnormal_nervous_system0.89884907
72MP0004270_analgesia0.87726384
73MP0005584_abnormal_enzyme/coenzyme_acti0.87388152
74MP0000266_abnormal_heart_morphology0.85056369
75MP0005623_abnormal_meninges_morphology0.85049148
76MP0003183_abnormal_peptide_metabolism0.84981443
77MP0003191_abnormal_cellular_cholesterol0.84078691
78MP0002108_abnormal_muscle_morphology0.80593488
79MP0005360_urolithiasis0.80340340
80MP0002139_abnormal_hepatobiliary_system0.80076073
81MP0010329_abnormal_lipoprotein_level0.79666112
82MP0005266_abnormal_metabolism0.78785325
83MP0005386_behavior/neurological_phenoty0.77380345
84MP0004924_abnormal_behavior0.77380345
85MP0003950_abnormal_plasma_membrane0.76693671
86MP0002272_abnormal_nervous_system0.75740100
87MP0005165_increased_susceptibility_to0.75039789
88MP0005334_abnormal_fat_pad0.71556232
89MP0008569_lethality_at_weaning0.71013234
90MP0005365_abnormal_bile_salt0.70168401
91MP0005319_abnormal_enzyme/_coenzyme0.67781624
92MP0009046_muscle_twitch0.67611997
93MP0000343_altered_response_to0.67093754
94MP0001765_abnormal_ion_homeostasis0.66648299
95MP0002066_abnormal_motor_capabilities/c0.66234065
96MP0005167_abnormal_blood-brain_barrier0.65663350
97MP0002970_abnormal_white_adipose0.65272034
98MP0003195_calcinosis0.63608078
99MP0005448_abnormal_energy_balance0.62926619
100MP0009745_abnormal_behavioral_response0.62482005
101MP0004147_increased_porphyrin_level0.62058782
102MP0002064_seizures0.61870062
103MP0001502_abnormal_circadian_rhythm0.61716556
104MP0002063_abnormal_learning/memory/cond0.61378468
105MP0009643_abnormal_urine_homeostasis0.61249142
106MP0003567_abnormal_fetal_cardiomyocyte0.61057868
107MP0009115_abnormal_fat_cell0.60716146
108MP0010234_abnormal_vibrissa_follicle0.60386327
109MP0001661_extended_life_span0.59989319
110MP0003880_abnormal_central_pattern0.59140379
111MP0003566_abnormal_cell_adhesion0.58496684
112MP0001756_abnormal_urination0.57911550
113MP0003656_abnormal_erythrocyte_physiolo0.57429626
114MP0001501_abnormal_sleep_pattern0.57294956
115MP0005452_abnormal_adipose_tissue0.56169044
116MP0003279_aneurysm0.54743766
117MP0001849_ear_inflammation0.54702359
118MP0003283_abnormal_digestive_organ0.54326897
119MP0002572_abnormal_emotion/affect_behav0.53728210
120MP0001486_abnormal_startle_reflex0.53466785
121MP0003633_abnormal_nervous_system0.52191953
122MP0000733_abnormal_muscle_development0.52058418
123MP0003806_abnormal_nucleotide_metabolis0.51255141
124MP0005187_abnormal_penis_morphology0.50427428
125MP0005085_abnormal_gallbladder_physiolo0.48646477
126MP0003690_abnormal_glial_cell0.48576780
127MP0009840_abnormal_foam_cell0.47989999
128MP0003045_fibrosis0.47790273

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.04126815
2Nemaline bodies (HP:0003798)5.60649359
3Exercise-induced myalgia (HP:0003738)5.52386069
4Myoglobinuria (HP:0002913)5.45566850
5Exercise-induced muscle cramps (HP:0003710)4.99187446
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.72080632
7Ventricular tachycardia (HP:0004756)4.51321322
8Calf muscle hypertrophy (HP:0008981)4.44926326
9Distal lower limb muscle weakness (HP:0009053)4.25228294
10Muscle fiber splitting (HP:0003555)4.19357195
11Atrial fibrillation (HP:0005110)4.15818402
12Muscle hypertrophy of the lower extremities (HP:0008968)4.12347219
13Myopathic facies (HP:0002058)4.05251663
14Bundle branch block (HP:0011710)4.01407558
15Rhabdomyolysis (HP:0003201)3.97312091
16Primary atrial arrhythmia (HP:0001692)3.89930834
17Hyporeflexia of lower limbs (HP:0002600)3.88498796
18Abnormality of the calf musculature (HP:0001430)3.83967802
19Difficulty running (HP:0009046)3.80079717
20Ketoacidosis (HP:0001993)3.76071530
21Supraventricular tachycardia (HP:0004755)3.73884050
22Supraventricular arrhythmia (HP:0005115)3.68148675
23Lipoatrophy (HP:0100578)3.62535093
24Palpitations (HP:0001962)3.62499882
25Syncope (HP:0001279)3.54673519
26Abnormality of the left ventricular outflow tract (HP:0011103)3.52518826
27Subaortic stenosis (HP:0001682)3.52518826
28Hypoglycemic coma (HP:0001325)3.51440652
29Right ventricular cardiomyopathy (HP:0011663)3.50223630
30Prolonged QT interval (HP:0001657)3.37841185
31Ventricular fibrillation (HP:0001663)3.31523093
32Asymmetric septal hypertrophy (HP:0001670)3.30301765
33Distal lower limb amyotrophy (HP:0008944)3.24972047
34Abnormality of fatty-acid metabolism (HP:0004359)3.23729891
35Increased connective tissue (HP:0009025)3.23167025
36Ventricular arrhythmia (HP:0004308)3.22348205
37Dilated cardiomyopathy (HP:0001644)3.20479447
38Heart block (HP:0012722)3.16537282
39Hyperglycinuria (HP:0003108)3.15167541
40Atrioventricular block (HP:0001678)3.14836686
41EMG: myopathic abnormalities (HP:0003458)3.12294072
42Rimmed vacuoles (HP:0003805)3.06744764
43Pheochromocytoma (HP:0002666)3.05261986
44Abnormality of the foot musculature (HP:0001436)3.01870779
45Foot dorsiflexor weakness (HP:0009027)2.96397637
46Dicarboxylic aciduria (HP:0003215)2.95526713
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95526713
48Abnormal atrioventricular conduction (HP:0005150)2.94460407
49Ketosis (HP:0001946)2.92237898
50Myotonia (HP:0002486)2.89277107
51Hepatic necrosis (HP:0002605)2.85371637
52Dysmetric saccades (HP:0000641)2.80163945
53Muscle stiffness (HP:0003552)2.76654847
54Lower limb amyotrophy (HP:0007210)2.74630757
55Conjunctival hamartoma (HP:0100780)2.71939254
56Distal arthrogryposis (HP:0005684)2.68992576
57Frequent falls (HP:0002359)2.64866389
58Increased muscle lipid content (HP:0009058)2.64405438
59Neuroendocrine neoplasm (HP:0100634)2.61252089
60Ankle clonus (HP:0011448)2.59026084
61Type 1 muscle fiber predominance (HP:0003803)2.58550749
62Abnormality of glycine metabolism (HP:0010895)2.57727882
63Abnormality of serine family amino acid metabolism (HP:0010894)2.57727882
64Abnormal EKG (HP:0003115)2.54096140
65Round ear (HP:0100830)2.53460034
66Difficulty climbing stairs (HP:0003551)2.51765504
67Increased variability in muscle fiber diameter (HP:0003557)2.51589580
68Hamartoma of the eye (HP:0010568)2.50500857
69Myokymia (HP:0002411)2.49667862
70Abnormal gallbladder physiology (HP:0012438)2.41754905
71Cholecystitis (HP:0001082)2.41754905
72Hyperammonemia (HP:0001987)2.41373874
73Bulbar palsy (HP:0001283)2.39210751
74Abnormal mitochondria in muscle tissue (HP:0008316)2.38378127
75Generalized aminoaciduria (HP:0002909)2.37443704
76Ragged-red muscle fibers (HP:0003200)2.29316541
77Abnormality of skeletal muscle fiber size (HP:0012084)2.25944972
78Ulnar deviation of the wrist (HP:0003049)2.25876273
79Neoplasm of the adrenal gland (HP:0100631)2.24444967
80Acute encephalopathy (HP:0006846)2.18823307
81Muscle fiber inclusion bodies (HP:0100299)2.16813431
82Hepatocellular necrosis (HP:0001404)2.16330080
83Gout (HP:0001997)2.12500682
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11442389
85Left ventricular hypertrophy (HP:0001712)2.08625366
86Areflexia of lower limbs (HP:0002522)2.08202303
87Abnormality of alanine metabolism (HP:0010916)2.08116063
88Hyperalaninemia (HP:0003348)2.08116063
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08116063
90Acute necrotizing encephalopathy (HP:0006965)2.06418481
91Cerebral edema (HP:0002181)2.06147307
92Proximal tubulopathy (HP:0000114)2.02810149
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02322189
94Lymphangioma (HP:0100764)2.00465314
95Limb-girdle muscle atrophy (HP:0003797)1.99757800
96Facial diplegia (HP:0001349)1.96756207
97Neurofibrillary tangles (HP:0002185)1.96555621
98Generalized muscle weakness (HP:0003324)1.95500274
99Neck muscle weakness (HP:0000467)1.94551013
100Hyperinsulinemic hypoglycemia (HP:0000825)1.94539323
101Lactic acidosis (HP:0003128)1.94254362
102Central scotoma (HP:0000603)1.90531271
103Abnormality of glycolysis (HP:0004366)1.90410608
104Increased serum pyruvate (HP:0003542)1.90410608
105Cholelithiasis (HP:0001081)1.90195720
106Upper limb amyotrophy (HP:0009129)1.89884243
107Distal upper limb amyotrophy (HP:0007149)1.89884243
108Large for gestational age (HP:0001520)1.88825781
109Increased intramyocellular lipid droplets (HP:0012240)1.88342649
110Neoplasm of head and neck (HP:0012288)1.88120748
111Esophageal neoplasm (HP:0100751)1.88120748
112Sudden cardiac death (HP:0001645)1.87806623
113Axonal loss (HP:0003447)1.87034096
114Neoplasm of the peripheral nervous system (HP:0100007)1.86024769
115Progressive muscle weakness (HP:0003323)1.84865707
116EMG: neuropathic changes (HP:0003445)1.84604421
117Cerebral inclusion bodies (HP:0100314)1.83386235
118Tinnitus (HP:0000360)1.83300759
119Mildly elevated creatine phosphokinase (HP:0008180)1.81782713
120Calcaneovalgus deformity (HP:0001848)1.79560892
121Rapidly progressive (HP:0003678)1.78763148
122Spinal rigidity (HP:0003306)1.78527715
123Supranuclear gaze palsy (HP:0000605)1.77325835
124Progressive macrocephaly (HP:0004481)1.77064527
125Hyperuricemia (HP:0002149)1.75253917
126Increased purine levels (HP:0004368)1.75253917
127Scapular winging (HP:0003691)1.73749501
128Oligomenorrhea (HP:0000876)1.72523447
129Metabolic acidosis (HP:0001942)1.72466448
130Gowers sign (HP:0003391)1.72198188
131Resting tremor (HP:0002322)1.71763829
132Tetraplegia (HP:0002445)1.67870115
133Steppage gait (HP:0003376)1.67325654
134Abnormal gallbladder morphology (HP:0012437)1.62825409
135Achilles tendon contracture (HP:0001771)1.59343016
136Neuronal loss in central nervous system (HP:0002529)1.57205315
137Slow progression (HP:0003677)1.55136126
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.54051593
139Hammertoe (HP:0001765)1.54019895
140Abnormality of the shoulder girdle musculature (HP:0001435)1.51688014
141Deformed tarsal bones (HP:0008119)1.49150310
142Depression (HP:0000716)1.49059405
143Reticulocytosis (HP:0001923)1.49016516
144Diaphragmatic weakness (HP:0009113)1.48450517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.15924728
2PDK33.98265006
3PDK43.98265006
4TTN3.93795257
5LMTK23.61062513
6PHKG23.28995989
7PHKG13.28995989
8PKN23.18817832
9NEK13.04969066
10BCKDK2.89843881
11OBSCN2.82828061
12PRPF4B2.63761327
13PDK22.30013035
14DMPK1.95394892
15MYLK1.94190448
16PINK11.88999232
17PRKD31.78355929
18WNK41.72260152
19TESK11.68241221
20ERN11.66657822
21ARAF1.56592328
22RIPK11.55726102
23LIMK11.40485891
24UHMK11.31738048
25PIK3CA1.25824117
26PAK31.22474857
27PAK61.21377850
28MAP3K71.21149526
29MAP3K111.19439583
30KSR21.19352470
31STK381.16341666
32TESK21.13498434
33CAMK1D1.10597427
34TIE11.09315801
35SIK11.07292892
36SMG11.07079475
37MAP3K91.05577459
38EPHA41.04687560
39PDGFRA1.03527867
40CCNB10.99620887
41PRKAA10.98068901
42STK240.96802256
43MAP3K40.96692077
44ILK0.94973388
45CAMK1G0.93831151
46PRKD10.92653455
47CAMK2B0.91071327
48TAOK20.85679463
49FGFR40.85660737
50MAP2K40.85373211
51PDPK10.85282871
52NTRK30.83323511
53PRKCH0.82762737
54PRKAA20.82665260
55CAMKK10.82520994
56WNK10.81883997
57CDC42BPA0.81673734
58ICK0.80054755
59MUSK0.77838070
60CAMK2D0.77690095
61PDK10.77605522
62SGK30.77507704
63NEK90.77425150
64ROCK10.77049021
65DAPK20.76365028
66WNK30.75602397
67MAPK120.74991427
68MAPK40.74899593
69RET0.74282697
70RIPK40.74167053
71PIM20.73088279
72MAP3K130.69718236
73MARK20.69469459
74PRKG20.69032894
75MINK10.68057805
76INSRR0.66016540
77PTK60.65969567
78DYRK1B0.63886095
79TAOK10.63734115
80CDK150.61068223
81MARK10.60951259
82CDK11A0.59272250
83DAPK30.59136868
84EPHA30.57265917
85CAMK10.56550175
86CDK180.55997034
87SGK4940.54367495
88SGK2230.54367495
89CAMK40.53568270
90TBK10.53492953
91EEF2K0.53223203
92DAPK10.51950546
93NTRK10.51691214
94KSR10.51631596
95LATS20.51415468
96PRKACG0.50753423
97STK390.50506661
98MAPK100.50421143
99MAP3K50.50387054
100CDK140.50004129
101EPHB10.49747109
102PTK2B0.49515291
103OXSR10.48708353
104MAP2K10.47297005
105CDK50.47270249
106BRAF0.47065756
107MAPKAPK30.46999255
108PKN10.46380679
109MAPK70.45628578
110CAMK2A0.44717482
111TYRO30.44412095
112DDR20.44356825
113ROCK20.44335161
114ALK0.43810164
115RPS6KA20.42923788
116FER0.42487690
117SGK20.42360235
118STK110.41424936
119STK38L0.41175717
120PIK3CG0.41092848
121MOS0.40153266
122MST1R0.40096175
123AKT20.39352622
124SGK10.39296568
125MAP3K30.38966327
126NTRK20.37593277
127PRKACB0.37535676
128FLT30.36763386
129RPS6KA30.36288064
130MTOR0.34106361
131BMX0.33282896
132CAMK2G0.33203015
133NME10.31815760
134PRKACA0.31222149
135MAP2K30.30437663
136LRRK20.29276389
137MAP3K10.27821582
138MAPK110.26482334
139SCYL20.25443358

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.75689885
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81140910
3Propanoate metabolism_Homo sapiens_hsa006403.61527989
4Fatty acid degradation_Homo sapiens_hsa000713.06300998
5Fatty acid metabolism_Homo sapiens_hsa012122.72151502
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68064093
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59964094
8Cardiac muscle contraction_Homo sapiens_hsa042602.53899054
9* Carbon metabolism_Homo sapiens_hsa012002.46581332
10Pyruvate metabolism_Homo sapiens_hsa006202.21843978
11Dilated cardiomyopathy_Homo sapiens_hsa054142.12475293
12Butanoate metabolism_Homo sapiens_hsa006502.08721596
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.97529428
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92168330
15* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72523743
16PPAR signaling pathway_Homo sapiens_hsa033201.70895659
17Parkinsons disease_Homo sapiens_hsa050121.64633102
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58963783
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56792479
20Oxidative phosphorylation_Homo sapiens_hsa001901.53110388
21Fatty acid biosynthesis_Homo sapiens_hsa000611.50457035
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47591672
23Nitrogen metabolism_Homo sapiens_hsa009101.38294444
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38252117
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38108754
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36857410
27Alzheimers disease_Homo sapiens_hsa050101.25138394
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22506981
29Glucagon signaling pathway_Homo sapiens_hsa049221.20625470
30* Biosynthesis of amino acids_Homo sapiens_hsa012301.17325423
31Fatty acid elongation_Homo sapiens_hsa000621.09930989
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.08885108
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07980148
34Histidine metabolism_Homo sapiens_hsa003401.06105004
35Insulin resistance_Homo sapiens_hsa049311.04322040
36Arginine biosynthesis_Homo sapiens_hsa002201.03374116
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02168013
38Prion diseases_Homo sapiens_hsa050201.01954307
39Insulin signaling pathway_Homo sapiens_hsa049101.01718097
40beta-Alanine metabolism_Homo sapiens_hsa004100.99727712
41Tryptophan metabolism_Homo sapiens_hsa003800.97132624
42AMPK signaling pathway_Homo sapiens_hsa041520.95900979
43Gastric acid secretion_Homo sapiens_hsa049710.95075921
44Huntingtons disease_Homo sapiens_hsa050160.89452945
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87433579
46Type II diabetes mellitus_Homo sapiens_hsa049300.85866801
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85166708
48Starch and sucrose metabolism_Homo sapiens_hsa005000.84526955
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81401515
50Other glycan degradation_Homo sapiens_hsa005110.81062193
51Insulin secretion_Homo sapiens_hsa049110.80918124
52Lysine degradation_Homo sapiens_hsa003100.76838217
53Circadian entrainment_Homo sapiens_hsa047130.76641514
54Bile secretion_Homo sapiens_hsa049760.76636278
55Renin secretion_Homo sapiens_hsa049240.76599466
56Glycerolipid metabolism_Homo sapiens_hsa005610.74798991
57Oxytocin signaling pathway_Homo sapiens_hsa049210.74197134
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71982115
59Calcium signaling pathway_Homo sapiens_hsa040200.70608513
60Mineral absorption_Homo sapiens_hsa049780.70030155
61Olfactory transduction_Homo sapiens_hsa047400.69228742
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.69191078
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69008839
64Vibrio cholerae infection_Homo sapiens_hsa051100.68992823
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67871621
66Peroxisome_Homo sapiens_hsa041460.67787232
67Fructose and mannose metabolism_Homo sapiens_hsa000510.67556212
68Salivary secretion_Homo sapiens_hsa049700.66425908
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65871193
70Renin-angiotensin system_Homo sapiens_hsa046140.65342740
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63620658
72Tyrosine metabolism_Homo sapiens_hsa003500.63157428
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61706255
74Synaptic vesicle cycle_Homo sapiens_hsa047210.61689998
75Long-term potentiation_Homo sapiens_hsa047200.61626931
76GABAergic synapse_Homo sapiens_hsa047270.60771437
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58910161
78Viral myocarditis_Homo sapiens_hsa054160.56082267
79Galactose metabolism_Homo sapiens_hsa000520.54184063
80Fat digestion and absorption_Homo sapiens_hsa049750.53673536
81cAMP signaling pathway_Homo sapiens_hsa040240.51861755
82Sulfur relay system_Homo sapiens_hsa041220.50798173
83Cocaine addiction_Homo sapiens_hsa050300.50085048
84HIF-1 signaling pathway_Homo sapiens_hsa040660.49625897
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48448052
86Cholinergic synapse_Homo sapiens_hsa047250.48190385
87Morphine addiction_Homo sapiens_hsa050320.48178164
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.47557568
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46609410
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46292483
91mTOR signaling pathway_Homo sapiens_hsa041500.45535105
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44039864
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43941557
94Dopaminergic synapse_Homo sapiens_hsa047280.43879150
95Gap junction_Homo sapiens_hsa045400.42850127
96Vitamin B6 metabolism_Homo sapiens_hsa007500.42407278
97Phenylalanine metabolism_Homo sapiens_hsa003600.40635877
98Focal adhesion_Homo sapiens_hsa045100.39778867
99Tight junction_Homo sapiens_hsa045300.39391170
100Glutamatergic synapse_Homo sapiens_hsa047240.38078474
101GnRH signaling pathway_Homo sapiens_hsa049120.37853459
102Amphetamine addiction_Homo sapiens_hsa050310.37508093
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35300749
104Arginine and proline metabolism_Homo sapiens_hsa003300.34945891
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.34557934
106Estrogen signaling pathway_Homo sapiens_hsa049150.34533502
107Melanogenesis_Homo sapiens_hsa049160.33057277
108Pentose phosphate pathway_Homo sapiens_hsa000300.32305129
109Protein digestion and absorption_Homo sapiens_hsa049740.29926742
110Pancreatic secretion_Homo sapiens_hsa049720.29418527
111Thyroid hormone synthesis_Homo sapiens_hsa049180.29300670
112Glioma_Homo sapiens_hsa052140.28998609
113Circadian rhythm_Homo sapiens_hsa047100.25648949
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.23317997
115Collecting duct acid secretion_Homo sapiens_hsa049660.23248522
116Sulfur metabolism_Homo sapiens_hsa009200.20939236
117Taste transduction_Homo sapiens_hsa047420.20708057
118VEGF signaling pathway_Homo sapiens_hsa043700.20224036
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.19867053
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.19244607

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