ACO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.69706031
2L-phenylalanine catabolic process (GO:0006559)6.69706031
3L-phenylalanine metabolic process (GO:0006558)6.46593460
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46593460
5aromatic amino acid family catabolic process (GO:0009074)6.02129077
6alpha-linolenic acid metabolic process (GO:0036109)5.76930652
7glyoxylate metabolic process (GO:0046487)5.65720832
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.53728844
9cysteine metabolic process (GO:0006534)5.43178309
10indole-containing compound catabolic process (GO:0042436)5.41954019
11indolalkylamine catabolic process (GO:0046218)5.41954019
12tryptophan catabolic process (GO:0006569)5.41954019
13lysine catabolic process (GO:0006554)5.36860563
14lysine metabolic process (GO:0006553)5.36860563
15kynurenine metabolic process (GO:0070189)5.32081066
16sulfur amino acid catabolic process (GO:0000098)5.23002429
17bile acid biosynthetic process (GO:0006699)5.18692114
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15072355
19tryptophan metabolic process (GO:0006568)5.13823793
20urea metabolic process (GO:0019627)4.98255586
21urea cycle (GO:0000050)4.98255586
22homocysteine metabolic process (GO:0050667)4.80842262
23serine family amino acid catabolic process (GO:0009071)4.79983216
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.79031295
25complement activation, alternative pathway (GO:0006957)4.76851958
26amino-acid betaine metabolic process (GO:0006577)4.65413483
27negative regulation of fibrinolysis (GO:0051918)4.64024351
28regulation of triglyceride catabolic process (GO:0010896)4.62366135
29nitrogen cycle metabolic process (GO:0071941)4.58230319
30protein carboxylation (GO:0018214)4.57632984
31peptidyl-glutamic acid carboxylation (GO:0017187)4.57632984
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.57103956
33high-density lipoprotein particle remodeling (GO:0034375)4.54026979
34regulation of protein activation cascade (GO:2000257)4.50003244
35bile acid metabolic process (GO:0008206)4.46416487
36aromatic amino acid family metabolic process (GO:0009072)4.35986295
37regulation of fibrinolysis (GO:0051917)4.35338232
38alpha-amino acid catabolic process (GO:1901606)4.33993381
39plasma lipoprotein particle clearance (GO:0034381)4.30423419
40acetyl-CoA metabolic process (GO:0006084)4.28510812
41cellular ketone body metabolic process (GO:0046950)4.24960635
42regulation of complement activation (GO:0030449)4.24821464
43acylglycerol homeostasis (GO:0055090)4.22756281
44triglyceride homeostasis (GO:0070328)4.22756281
45triglyceride catabolic process (GO:0019433)4.19772435
46tyrosine metabolic process (GO:0006570)4.17288649
47serine family amino acid metabolic process (GO:0009069)4.12144959
48cellular amino acid catabolic process (GO:0009063)4.11266869
49regulation of cholesterol esterification (GO:0010872)4.11264095
50reverse cholesterol transport (GO:0043691)4.10943100
51fatty acid beta-oxidation (GO:0006635)4.10202571
52valine metabolic process (GO:0006573)4.05771294
53negative regulation of cholesterol transport (GO:0032375)4.05217633
54negative regulation of sterol transport (GO:0032372)4.05217633
55plasma lipoprotein particle remodeling (GO:0034369)4.04262977
56protein-lipid complex remodeling (GO:0034368)4.04262977
57macromolecular complex remodeling (GO:0034367)4.04262977
58short-chain fatty acid metabolic process (GO:0046459)4.03763833
59ethanol oxidation (GO:0006069)4.03737562
60cellular modified amino acid catabolic process (GO:0042219)4.01040656
61drug catabolic process (GO:0042737)3.99269442
62glycine metabolic process (GO:0006544)3.99177538
63urate metabolic process (GO:0046415)3.98076127
64fatty acid oxidation (GO:0019395)3.95856518
65drug transmembrane transport (GO:0006855)3.94244991
662-oxoglutarate metabolic process (GO:0006103)3.92829343
67serine family amino acid biosynthetic process (GO:0009070)3.90884257
68glutamate metabolic process (GO:0006536)3.90825051
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.88786986
70lipid oxidation (GO:0034440)3.88701162
71acylglycerol catabolic process (GO:0046464)3.88069217
72neutral lipid catabolic process (GO:0046461)3.88069217
73cellular glucuronidation (GO:0052695)3.86491635
74aspartate family amino acid catabolic process (GO:0009068)3.83720426
75coenzyme catabolic process (GO:0009109)3.82933928
76indolalkylamine metabolic process (GO:0006586)3.79150386
77phospholipid efflux (GO:0033700)3.79105610
78fatty acid catabolic process (GO:0009062)3.78882710
79regulation of cholesterol homeostasis (GO:2000188)3.78294663
80benzene-containing compound metabolic process (GO:0042537)3.77591370
81organic acid catabolic process (GO:0016054)3.76552309
82carboxylic acid catabolic process (GO:0046395)3.76552309
83positive regulation of lipid catabolic process (GO:0050996)3.74615517
84regulation of plasminogen activation (GO:0010755)3.72661123
85monocarboxylic acid catabolic process (GO:0072329)3.72563504
86cell adhesion mediated by integrin (GO:0033627)3.68291440
87amine catabolic process (GO:0009310)3.67956582
88cellular biogenic amine catabolic process (GO:0042402)3.67956582
89carnitine metabolic process (GO:0009437)3.67496957
90ketone body metabolic process (GO:1902224)3.67169171
91phospholipid homeostasis (GO:0055091)3.66939510
92bile acid and bile salt transport (GO:0015721)3.66825483
93fatty acid homeostasis (GO:0055089)3.63202019
94fibrinolysis (GO:0042730)3.63179957
95dicarboxylic acid biosynthetic process (GO:0043650)3.60476613
96branched-chain amino acid catabolic process (GO:0009083)3.59338210
97aldehyde catabolic process (GO:0046185)3.58986302
98cholesterol homeostasis (GO:0042632)3.55350181
99NADH metabolic process (GO:0006734)3.53908269
100cholesterol efflux (GO:0033344)3.53106920
101sterol homeostasis (GO:0055092)3.51973451
102plasma lipoprotein particle assembly (GO:0034377)3.51617513
103glucuronate metabolic process (GO:0019585)3.51092110
104uronic acid metabolic process (GO:0006063)3.51092110
105branched-chain amino acid metabolic process (GO:0009081)3.50876583
106apoptotic cell clearance (GO:0043277)3.49677420
107regulation of sequestering of triglyceride (GO:0010889)3.48595588
108low-density lipoprotein particle clearance (GO:0034383)3.47122893
109biotin metabolic process (GO:0006768)3.46755150
110positive regulation of lipoprotein lipase activity (GO:0051006)3.46246817
111positive regulation of triglyceride lipase activity (GO:0061365)3.46246817
112protein heterotrimerization (GO:0070208)3.45499223
113imidazole-containing compound metabolic process (GO:0052803)3.44186657
114endodermal cell differentiation (GO:0035987)3.39842585
115retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39468521
116positive regulation of endothelial cell apoptotic process (GO:2000353)3.19509707
117COPI coating of Golgi vesicle (GO:0048205)3.16309228
118Golgi transport vesicle coating (GO:0048200)3.16309228
119polyketide metabolic process (GO:0030638)3.15074812
120doxorubicin metabolic process (GO:0044598)3.15074812
121daunorubicin metabolic process (GO:0044597)3.15074812
122barbed-end actin filament capping (GO:0051016)3.13083485
123epoxygenase P450 pathway (GO:0019373)3.03003019
124basement membrane organization (GO:0071711)3.02694512
125omega-hydroxylase P450 pathway (GO:0097267)3.00653473
126regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.00012452
127skin morphogenesis (GO:0043589)2.97532465
128oxaloacetate metabolic process (GO:0006107)2.92562861
129negative regulation of fatty acid transport (GO:2000192)2.86821445
130endothelial cell morphogenesis (GO:0001886)2.84457273
131negative regulation of lipase activity (GO:0060192)2.82265095
132cellular response to vitamin (GO:0071295)2.80524214
133fatty-acyl-CoA biosynthetic process (GO:0046949)2.80003032
134negative regulation of smooth muscle cell migration (GO:0014912)2.79259905
135aminoglycoside antibiotic metabolic process (GO:0030647)2.79009694
136triglyceride biosynthetic process (GO:0019432)2.78759783
137triglyceride metabolic process (GO:0006641)2.78714773
138regulation of cholesterol storage (GO:0010885)2.75860069
139midgut development (GO:0007494)2.75244230
140collagen fibril organization (GO:0030199)2.73741908
141ethanol metabolic process (GO:0006067)2.72919565
142negative regulation of blood coagulation (GO:0030195)2.72152174
143negative regulation of hemostasis (GO:1900047)2.72152174
144negative regulation of coagulation (GO:0050819)2.70973511
145acylglycerol biosynthetic process (GO:0046463)2.70497340
146neutral lipid biosynthetic process (GO:0046460)2.70497340
147glycerolipid catabolic process (GO:0046503)2.69587696
148positive regulation of hemostasis (GO:1900048)2.67257884
149positive regulation of blood coagulation (GO:0030194)2.67257884
150thioester metabolic process (GO:0035383)2.66282653
151acyl-CoA metabolic process (GO:0006637)2.66282653
152negative regulation of wound healing (GO:0061045)2.65893900
153fatty-acyl-CoA metabolic process (GO:0035337)2.65576298
154COPII vesicle coating (GO:0048208)2.64401569
155thioester biosynthetic process (GO:0035384)2.63163090
156acyl-CoA biosynthetic process (GO:0071616)2.63163090
157positive regulation of coagulation (GO:0050820)2.59880675
158lipid storage (GO:0019915)2.58901073
159positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58434453
160negative regulation of lipid transport (GO:0032369)2.57423901
161chondrocyte proliferation (GO:0035988)2.56894844
162acylglycerol metabolic process (GO:0006639)2.56039617
163regulation of apoptotic cell clearance (GO:2000425)2.55641311
164neutral lipid metabolic process (GO:0006638)2.51727168
165negative regulation of protein activation cascade (GO:2000258)2.50935916
166adhesion of symbiont to host cell (GO:0044650)2.50895887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.75021895
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.81168302
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.77039902
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.09671479
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.78556949
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.57425424
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.36750712
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83336740
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.45717834
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11320662
11CLOCK_20551151_ChIP-Seq_293T_Human2.73936846
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30213189
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.26766579
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26597938
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07651196
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.07252668
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8618654
18CJUN_26792858_Chip-Seq_BT549_Human1.88549896
19BRD4_25478319_ChIP-Seq_HGPS_Human1.85481493
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.79643592
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.75435154
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69380231
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68629578
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67254764
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.65138713
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.64568665
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62640606
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62640606
29NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.58745116
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48719212
31GATA1_22025678_ChIP-Seq_K562_Human1.46344612
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44365326
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.41153953
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36977236
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35400478
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34995466
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33709009
38* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33003446
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30744911
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27625099
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26888427
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22834874
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22237174
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20768360
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20076140
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19910220
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.18770772
48GATA4_25053715_ChIP-Seq_YYC3_Human1.18090512
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16944406
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.14633554
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12003422
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11584245
53ZNF263_19887448_ChIP-Seq_K562_Human1.11179666
54GATA4_21415370_ChIP-Seq_HL-1_Mouse1.11023734
55* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10166651
56EOMES_21245162_ChIP-Seq_HESCs_Human1.10119033
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08138386
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07256297
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.07193320
60TP53_18474530_ChIP-ChIP_U2OS_Human1.01807915
61* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00631950
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.00191982
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99208933
64RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99161976
65TP63_17297297_ChIP-ChIP_HaCaT_Human0.98781873
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98411672
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98276469
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97893827
69MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97185382
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95897346
71SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94553697
72SOX17_20123909_ChIP-Seq_XEN_Mouse0.93717001
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93152912
74* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91354037
75ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90833920
76SA1_22415368_ChIP-Seq_MEFs_Mouse0.90624341
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.90487291
78* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89814930
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89467900
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.87685270
81* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87323159
82HTT_18923047_ChIP-ChIP_STHdh_Human0.87077964
83AR_21909140_ChIP-Seq_LNCAP_Human0.86360281
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85460210
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84937551
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84518258
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84059099
88MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83705381
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83116156
90TP53_22127205_ChIP-Seq_IMR90_Human0.82627541
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82231085
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81361191
93GATA6_25053715_ChIP-Seq_YYC3_Human0.80243035
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80067237
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79142726
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79134640
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78615478
98* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78230933
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76954291
100* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76513827
101LXR_22292898_ChIP-Seq_THP-1_Human0.74954111
102RACK7_27058665_Chip-Seq_MCF-7_Human0.70496629
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70334760
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70001116
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70001116
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68140166
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67437914
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.67008025
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66886652
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.66660066
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66431268
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64852872
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.63342175
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63256236
115CEBPB_22108803_ChIP-Seq_LS180_Human0.63119317
116SOX2_20726797_ChIP-Seq_SW620_Human0.62618386
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62070253
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.60630925
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.60630925
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.60060395
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59240473
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.58402423
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.58363709
124GATA1_19941826_ChIP-Seq_K562_Human0.58275906
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58029503
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.56755736
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.56313006
128ATF3_27146783_Chip-Seq_COLON_Human0.55354104
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54986201
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.54810380
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53620208
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53128043
133GATA2_19941826_ChIP-Seq_K562_Human0.51958169
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50741624
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.49947074
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.49548793
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.48610339
138EGR1_19032775_ChIP-ChIP_M12_Human0.47542551
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.45838637
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44100022
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43744889
142MYC_19915707_ChIP-ChIP_AK7_Human0.43533560
143AR_20517297_ChIP-Seq_VCAP_Human0.42714136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58046416
2MP0005360_urolithiasis7.56450367
3MP0005365_abnormal_bile_salt5.52575066
4MP0005085_abnormal_gallbladder_physiolo5.47434757
5MP0008875_abnormal_xenobiotic_pharmacok4.41977095
6MP0003806_abnormal_nucleotide_metabolis3.92886668
7MP0003252_abnormal_bile_duct3.57462804
8MP0010329_abnormal_lipoprotein_level3.49302865
9MP0005332_abnormal_amino_acid2.99429095
10MP0009840_abnormal_foam_cell2.93869562
11MP0003950_abnormal_plasma_membrane2.78194634
12MP0005083_abnormal_biliary_tract2.62176586
13MP0003195_calcinosis2.61419881
14MP0003566_abnormal_cell_adhesion2.51615692
15MP0001666_abnormal_nutrient_absorption2.49718142
16MP0004019_abnormal_vitamin_homeostasis2.49660400
17MP0003191_abnormal_cellular_cholesterol2.45887209
18MP0003279_aneurysm2.30573547
19MP0005257_abnormal_intraocular_pressure2.25951144
20MP0002118_abnormal_lipid_homeostasis2.14772917
21MP0000609_abnormal_liver_physiology2.09894953
22MP0005670_abnormal_white_adipose2.03912155
23MP0003705_abnormal_hypodermis_morpholog2.02081064
24MP0002138_abnormal_hepatobiliary_system2.00194770
25MP0010352_gastrointestinal_tract_polyps1.97767279
26MP0003941_abnormal_skin_development1.87577292
27MP0001958_emphysema1.86425257
28MP0006054_spinal_hemorrhage1.83560915
29MP0005503_abnormal_tendon_morphology1.83467066
30MP0000751_myopathy1.82594342
31MP0005319_abnormal_enzyme/_coenzyme1.76929329
32MP0009643_abnormal_urine_homeostasis1.70021131
33MP0005584_abnormal_enzyme/coenzyme_acti1.57747374
34MP0001764_abnormal_homeostasis1.51042835
35MP0003091_abnormal_cell_migration1.50653351
36MP0005623_abnormal_meninges_morphology1.48864138
37MP0003186_abnormal_redox_activity1.46459775
38MP0002877_abnormal_melanocyte_morpholog1.45535436
39MP0005666_abnormal_adipose_tissue1.42455496
40MP0000003_abnormal_adipose_tissue1.41282362
41MP0003868_abnormal_feces_composition1.34846321
42MP0003011_delayed_dark_adaptation1.32001401
43MP0006138_congestive_heart_failure1.31816531
44MP0004130_abnormal_muscle_cell1.31694902
45MP0000013_abnormal_adipose_tissue1.27440787
46MP0000767_abnormal_smooth_muscle1.25621522
47MP0003828_pulmonary_edema1.22295616
48MP0009780_abnormal_chondrocyte_physiolo1.20858970
49MP0005595_abnormal_vascular_smooth1.20439386
50MP0001542_abnormal_bone_strength1.18979577
51MP0002896_abnormal_bone_mineralization1.17744081
52MP0000598_abnormal_liver_morphology1.15924799
53MP0005451_abnormal_body_composition1.15481610
54MP0000343_altered_response_to1.14487567
55MP0002971_abnormal_brown_adipose1.12265989
56MP0001756_abnormal_urination1.07855940
57MP0002254_reproductive_system_inflammat1.06376289
58MP0005164_abnormal_response_to1.04847290
59MP0000749_muscle_degeneration1.03061493
60MP0008438_abnormal_cutaneous_collagen1.02670951
61* MP0005636_abnormal_mineral_homeostasis0.99965528
62MP0004233_abnormal_muscle_weight0.98171459
63MP0004185_abnormal_adipocyte_glucose0.97502278
64MP0001243_abnormal_dermal_layer0.97325538
65MP0001661_extended_life_span0.96276523
66MP0000604_amyloidosis0.92375377
67MP0004858_abnormal_nervous_system0.92305137
68MP0009763_increased_sensitivity_to0.91649914
69MP0005165_increased_susceptibility_to0.91638648
70MP0005508_abnormal_skeleton_morphology0.91605522
71MP0009697_abnormal_copulation0.90561622
72MP0005334_abnormal_fat_pad0.90134419
73MP0004043_abnormal_pH_regulation0.89371217
74MP0001299_abnormal_eye_distance/0.88180518
75MP0004087_abnormal_muscle_fiber0.86845338
76MP0005647_abnormal_sex_gland0.85735857
77MP0001849_ear_inflammation0.85357119
78MP0000759_abnormal_skeletal_muscle0.84766045
79MP0002136_abnormal_kidney_physiology0.84469624
80MP0005084_abnormal_gallbladder_morpholo0.83071939
81MP0003656_abnormal_erythrocyte_physiolo0.83002458
82MP0002078_abnormal_glucose_homeostasis0.82474999
83MP0006036_abnormal_mitochondrial_physio0.81914836
84MP0002876_abnormal_thyroid_physiology0.81699525
85MP0004084_abnormal_cardiac_muscle0.81668153
86MP0009642_abnormal_blood_homeostasis0.80861394
87MP0005375_adipose_tissue_phenotype0.80838305
88MP0010368_abnormal_lymphatic_system0.79936317
89MP0005408_hypopigmentation0.78990713
90MP0009764_decreased_sensitivity_to0.78183838
91MP0009115_abnormal_fat_cell0.76343670
92MP0010030_abnormal_orbit_morphology0.76126638
93MP0005330_cardiomyopathy0.75153085
94MP0000858_altered_metastatic_potential0.74723703
95MP0005376_homeostasis/metabolism_phenot0.74640545
96MP0003690_abnormal_glial_cell0.73921395
97MP0005535_abnormal_body_temperature0.73217455
98MP0009053_abnormal_anal_canal0.72188241
99MP0008469_abnormal_protein_level0.71381227
100MP0003448_altered_tumor_morphology0.71165141
101MP0002108_abnormal_muscle_morphology0.70890474
102MP0005058_abnormal_lysosome_morphology0.70316242
103MP0005220_abnormal_exocrine_pancreas0.70139464
104MP0002128_abnormal_blood_circulation0.69833109
105MP0000733_abnormal_muscle_development0.69724701
106MP0002972_abnormal_cardiac_muscle0.69302078
107MP0000747_muscle_weakness0.68954754
108MP0004036_abnormal_muscle_relaxation0.67786435
109MP0001879_abnormal_lymphatic_vessel0.66555438
110MP0001614_abnormal_blood_vessel0.66141648
111MP0008775_abnormal_heart_ventricle0.65786079
112MP0005266_abnormal_metabolism0.64764470
113MP0005197_abnormal_uvea_morphology0.64693079
114MP0005448_abnormal_energy_balance0.64542638
115MP0005385_cardiovascular_system_phenoty0.63413482
116MP0001544_abnormal_cardiovascular_syste0.63413482
117MP0009765_abnormal_xenobiotic_induced0.62972340
118MP0003300_gastrointestinal_ulcer0.59520472
119MP0002970_abnormal_white_adipose0.59285576
120MP0002168_other_aberrant_phenotype0.59131666
121MP0001881_abnormal_mammary_gland0.57980874
122MP0005395_other_phenotype0.56182283
123MP0010234_abnormal_vibrissa_follicle0.55945009
124MP0009384_cardiac_valve_regurgitation0.53158878
125MP0002837_dystrophic_cardiac_calcinosis0.52485027
126MP0003329_amyloid_beta_deposits0.52482304
127MP0002796_impaired_skin_barrier0.51615149
128MP0004272_abnormal_basement_membrane0.51577588
129MP0003959_abnormal_lean_body0.50942478
130MP0009672_abnormal_birth_weight0.50118404
131MP0004782_abnormal_surfactant_physiolog0.49957142
132MP0005275_abnormal_skin_tensile0.47884153
133MP0004264_abnormal_extraembryonic_tissu0.47553654
134MP0001765_abnormal_ion_homeostasis0.46844819
135MP0008961_abnormal_basal_metabolism0.43706333
136MP0003953_abnormal_hormone_level0.43134201
137MP0002928_abnormal_bile_duct0.42318992
138MP0003638_abnormal_response/metabolism_0.41918523
139MP0002135_abnormal_kidney_morphology0.41341003
140MP0005167_abnormal_blood-brain_barrier0.40848211
141MP0005248_abnormal_Harderian_gland0.40680563
142MP0000230_abnormal_systemic_arterial0.40087018
143MP0002060_abnormal_skin_morphology0.39366548
144MP0003724_increased_susceptibility_to0.38942387
145MP0001915_intracranial_hemorrhage0.37952471
146MP0006035_abnormal_mitochondrial_morpho0.36695997
147MP0000249_abnormal_blood_vessel0.36499031
148MP0002295_abnormal_pulmonary_circulatio0.36059297
149MP0005023_abnormal_wound_healing0.35503100
150MP0008873_increased_physiological_sensi0.35004588
151MP0000639_abnormal_adrenal_gland0.34197581

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.28746582
2Deep venous thrombosis (HP:0002625)6.18782891
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.08158852
4Premature rupture of membranes (HP:0001788)5.85969114
5Xanthomatosis (HP:0000991)5.83854401
6Protrusio acetabuli (HP:0003179)5.78026781
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61651083
8Hypobetalipoproteinemia (HP:0003563)5.32928709
9Hyperglycinuria (HP:0003108)4.96307323
10Prolonged partial thromboplastin time (HP:0003645)4.93572927
11Complement deficiency (HP:0004431)4.74182283
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.72020246
13Hyperammonemia (HP:0001987)4.70019286
14Abnormality of glycine metabolism (HP:0010895)4.66035679
15Abnormality of serine family amino acid metabolism (HP:0010894)4.66035679
16Hyperlipoproteinemia (HP:0010980)4.62805916
17Ketosis (HP:0001946)4.46983760
18Hyperglycinemia (HP:0002154)4.43294905
19Epidermoid cyst (HP:0200040)4.29070387
20Hypolipoproteinemia (HP:0010981)4.27596332
21Hypoglycemic coma (HP:0001325)4.24583224
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.98548927
23Abnormality of fatty-acid metabolism (HP:0004359)3.97230405
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96105122
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95446773
26Hypoalphalipoproteinemia (HP:0003233)3.91030136
27Ankle contracture (HP:0006466)3.81236784
28Vertebral compression fractures (HP:0002953)3.80724342
29Joint hemorrhage (HP:0005261)3.73927582
30Abnormality of the common coagulation pathway (HP:0010990)3.69049249
31Vascular tortuosity (HP:0004948)3.64609080
32Ketoacidosis (HP:0001993)3.64352463
33Fat malabsorption (HP:0002630)3.61610233
34Aortic dissection (HP:0002647)3.59969327
35Aortic aneurysm (HP:0004942)3.52700459
36Abnormality of methionine metabolism (HP:0010901)3.43829076
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42747222
38Abnormality of complement system (HP:0005339)3.40928315
39Hypercholesterolemia (HP:0003124)3.39568858
40Arterial tortuosity (HP:0005116)3.38805211
41Abnormality of purine metabolism (HP:0004352)3.34684515
42Spinal rigidity (HP:0003306)3.30991899
43Gout (HP:0001997)3.29725048
44Abnormality of nucleobase metabolism (HP:0010932)3.27572606
45Abnormality of pyrimidine metabolism (HP:0004353)3.13348789
46Abnormality of the intrinsic pathway (HP:0010989)3.10063260
47Delayed CNS myelination (HP:0002188)3.08944936
48Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02299277
49Dicarboxylic aciduria (HP:0003215)3.02299277
50Cervical subluxation (HP:0003308)2.97652486
51Abnormality of serum amino acid levels (HP:0003112)2.96874291
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.92220621
53Osteolytic defects of the hand bones (HP:0009699)2.92220621
54Hepatocellular carcinoma (HP:0001402)2.90938823
55Conjugated hyperbilirubinemia (HP:0002908)2.90197535
56Soft skin (HP:0000977)2.88287050
57Myocardial infarction (HP:0001658)2.86021293
58Wormian bones (HP:0002645)2.85135446
59Hyperbilirubinemia (HP:0002904)2.81841182
60Metabolic acidosis (HP:0001942)2.79820917
61Abnormality of proline metabolism (HP:0010907)2.79172605
62Hydroxyprolinuria (HP:0003080)2.79172605
63Type 1 muscle fiber predominance (HP:0003803)2.76404192
64Spastic diplegia (HP:0001264)2.76387544
65Increased variability in muscle fiber diameter (HP:0003557)2.73665171
66Skin nodule (HP:0200036)2.72291378
67Generalized aminoaciduria (HP:0002909)2.71966671
68Follicular hyperkeratosis (HP:0007502)2.64379371
69Lethargy (HP:0001254)2.63945270
70Steatorrhea (HP:0002570)2.62921252
71Proximal tubulopathy (HP:0000114)2.60369924
72Increased purine levels (HP:0004368)2.53760993
73Hyperuricemia (HP:0002149)2.53760993
74Vascular calcification (HP:0004934)2.53104944
75Atrophic scars (HP:0001075)2.52670167
76Hypoglycemic seizures (HP:0002173)2.51263316
77Blue sclerae (HP:0000592)2.49616189
78Systemic lupus erythematosus (HP:0002725)2.48925584
79Bladder diverticulum (HP:0000015)2.45855178
80Abnormality of skeletal muscle fiber size (HP:0012084)2.44002199
81Short nail (HP:0001799)2.41389173
82Increased connective tissue (HP:0009025)2.40795470
83Abnormal cartilage morphology (HP:0002763)2.40632913
84Esophageal varix (HP:0002040)2.40378234
85Fragile skin (HP:0001030)2.40361055
86Malnutrition (HP:0004395)2.39176346
87Cardiovascular calcification (HP:0011915)2.35368962
88Shallow orbits (HP:0000586)2.35288182
89Abnormal delivery (HP:0001787)2.34343812
90Broad metatarsal (HP:0001783)2.32573874
91Abnormality of dentin (HP:0010299)2.30507599
92Irritability (HP:0000737)2.29091518
93Vomiting (HP:0002013)2.28452779
94Dilatation of the ascending aorta (HP:0005111)2.26807617
95Alkalosis (HP:0001948)2.26800464
96Pancreatitis (HP:0001733)2.23652308
97Enlarged kidneys (HP:0000105)2.22798839
98Mitral valve prolapse (HP:0001634)2.22100294
99Abnormality of the acetabulum (HP:0003170)2.21866013
100Nausea (HP:0002018)2.20727084
101Acanthosis nigricans (HP:0000956)2.19254192
102Sensorimotor neuropathy (HP:0007141)2.19107779
103Neonatal onset (HP:0003623)2.18965050
104Cerebral aneurysm (HP:0004944)2.18854230
105Cerebral edema (HP:0002181)2.18364905
106Late onset (HP:0003584)2.14605296
107Hemorrhage of the eye (HP:0011885)2.13128143
108Hypertriglyceridemia (HP:0002155)2.11806166
109Abnormality of the Achilles tendon (HP:0005109)2.09032393
110Abnormal gallbladder morphology (HP:0012437)2.09015966
111Acanthocytosis (HP:0001927)2.08877347
112Cholelithiasis (HP:0001081)2.07928609
113Spontaneous abortion (HP:0005268)2.07780764
114Biconcave vertebral bodies (HP:0004586)2.06966641
115Mitral stenosis (HP:0001718)2.06554213
116Abnormality of carpal bone ossification (HP:0006257)2.06396492
117Slender build (HP:0001533)2.06144578
118Abnormality of urine glucose concentration (HP:0011016)2.05743907
119Glycosuria (HP:0003076)2.05743907
120Aneurysm (HP:0002617)2.05181932
121Mildly elevated creatine phosphokinase (HP:0008180)2.04082885
122Hypochromic microcytic anemia (HP:0004840)2.01485323
123Hyperinsulinemic hypoglycemia (HP:0000825)2.00928543
124Glomerulonephritis (HP:0000099)2.00312408
125Abnormal enzyme/coenzyme activity (HP:0012379)1.99811387
126Abnormal gallbladder physiology (HP:0012438)1.96687828
127Cholecystitis (HP:0001082)1.96687828
128Rickets (HP:0002748)1.96295940
129Nephritis (HP:0000123)1.95542640
130Achilles tendon contracture (HP:0001771)1.95099149
131Brushfield spots (HP:0001088)1.94565424
132Tetraparesis (HP:0002273)1.94394831
133Ectopia lentis (HP:0001083)1.91071216
134Peritonitis (HP:0002586)1.90079863
135Urinary glycosaminoglycan excretion (HP:0003541)1.89400004
136Mucopolysacchariduria (HP:0008155)1.89400004
137Abnormality of liposaccharide metabolism (HP:0010968)1.88969413
138Abnormality of glycosphingolipid metabolism (HP:0004343)1.88969413
139Abnormality of glycolipid metabolism (HP:0010969)1.88969413
140Insulin resistance (HP:0000855)1.88220035
141Ulnar bowing (HP:0003031)1.87810941
142Joint laxity (HP:0001388)1.87648235
143Reduced subcutaneous adipose tissue (HP:0003758)1.86880684
144Neonatal short-limb short stature (HP:0008921)1.86009695
145Nephrolithiasis (HP:0000787)1.85488437
146Back pain (HP:0003418)1.84148847
147Amyloidosis (HP:0011034)1.83773544
148Increased mean platelet volume (HP:0011877)1.82751165
149Elbow flexion contracture (HP:0002987)1.82371281
150Polycythemia (HP:0001901)1.81150905
151Abnormality of the gallbladder (HP:0005264)1.80425790
152Hyperextensible skin (HP:0000974)1.80294673
153Ovoid vertebral bodies (HP:0003300)1.80142900
154Abnormal ossification of hand bones (HP:0005921)1.79638846
155Axonal loss (HP:0003447)1.79205032
156Asymmetric septal hypertrophy (HP:0001670)1.78539744
157Opisthotonus (HP:0002179)1.77441321
158Spondylolisthesis (HP:0003302)1.76089078
159Renal cortical cysts (HP:0000803)1.75498323
160Abnormality of polysaccharide metabolism (HP:0011012)1.75337241
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75337241
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75337241
163Abnormality of alkaline phosphatase activity (HP:0004379)1.75037631
164Hyperglycemia (HP:0003074)1.74599541
165Myoglobinuria (HP:0002913)1.73676847
166Recurrent gram-negative bacterial infections (HP:0005420)1.71588985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.39941513
2SIK14.43312070
3MYLK3.78902862
4ERN13.74680771
5TRIB33.62587348
6FGFR43.50418295
7PKN22.58399808
8CAMK1D2.54561318
9TIE12.31795832
10TESK12.28931755
11LATS12.18981563
12MST1R2.18257010
13INSRR2.12839680
14LIMK11.93159515
15ERBB41.92584557
16IRAK31.83398127
17NTRK11.75685785
18PTK61.74944734
19WNK41.56842572
20CAMK1G1.56244190
21MAPK111.48617539
22FRK1.47016580
23NEK91.45937066
24SCYL21.44233619
25TRPM71.42786216
26MET1.42651518
27MOS1.40369035
28RIPK11.39584660
29EPHB11.38530816
30FLT31.34721496
31PDK31.34318568
32PDK41.34318568
33FGFR21.31524866
34WNK31.31421544
35STK38L1.31005314
36TAOK31.23662174
37PRKAA21.21336351
38MAP3K101.11883476
39MAP3K31.07564893
40PDGFRA1.07004735
41MAP3K61.05530711
42ABL21.05392015
43AKT31.03341366
44BMX1.03167707
45STK381.02663073
46KDR1.01609327
47TYK20.99845983
48PRKG20.99133212
49CDK60.98944487
50OXSR10.96789933
51ERBB20.92762132
52JAK20.91897905
53MAP2K30.90845278
54LMTK20.90033064
55CDC42BPA0.89365879
56PIK3CG0.89226566
57GSK3A0.87212159
58TGFBR20.85330328
59PIM20.81461326
60PTK20.81390354
61MAP3K70.81113223
62ARAF0.80834705
63NEK10.78227128
64PRKAA10.78040518
65MTOR0.77332982
66PDK20.77197583
67ICK0.76766428
68TBK10.74070168
69EPHB20.71778351
70JAK10.71518677
71MAP2K40.71176462
72LRRK20.71150280
73GRK60.68373077
74MAP3K120.68363973
75ROCK20.67177045
76DAPK30.66137292
77DYRK1B0.65795812
78MAP2K10.65430857
79FGFR30.64883422
80LATS20.64846737
81ROCK10.63271692
82EPHA30.63132261
83PRKCZ0.62098201
84PRKACG0.58190283
85SGK30.56331429
86CDK40.56183387
87PRKD20.55904889
88STK30.55874568
89TTN0.55524537
90MAP2K20.55100581
91DMPK0.54947764
92PDPK10.51801849
93FGFR10.51340941
94TTK0.51260282
95DAPK20.51163115
96EPHA20.49563250
97CSK0.48378734
98PASK0.48363465
99MELK0.47984117
100FER0.45862718
101RET0.45455849
102KSR20.45219190
103SMG10.44445089
104BRSK20.44120457
105AKT20.44109035
106DDR20.43649002
107IGF1R0.43636830
108PAK40.43031033
109GRK70.41141019
110CLK10.40335857
111PAK20.40063647
112ILK0.39513257
113MAP3K50.39288528
114CAMK2G0.39088685
115RPS6KA20.39018476
116CAMK2D0.38868729
117SGK2230.38840764
118SGK4940.38840764
119MAPK40.38814341
120PAK10.38622071
121STK390.38382021
122CSF1R0.38007982
123NME20.37492439
124PAK30.37431504
125MAPKAPK30.37301330
126ADRBK10.37222173
127MAP3K110.35849252
128GRK50.34770421
129CSNK1G10.34433000
130STK40.34243528
131PIK3CA0.33655636
132CDK90.31760195
133TSSK60.30297107
134MAP3K80.29967543
135TAOK20.29687582
136PBK0.29027414
137TGFBR10.28777666
138EGFR0.28598386
139SRC0.27838249
140EEF2K0.27448643
141GRK10.26599774
142PDGFRB0.25871453

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79538793
2Nitrogen metabolism_Homo sapiens_hsa009103.45171111
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20383383
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84917260
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84004288
6Fatty acid degradation_Homo sapiens_hsa000712.81784982
7* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72479937
8Arginine biosynthesis_Homo sapiens_hsa002202.68328798
9Tryptophan metabolism_Homo sapiens_hsa003802.63075506
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62412561
11Propanoate metabolism_Homo sapiens_hsa006402.55270442
12Butanoate metabolism_Homo sapiens_hsa006502.41373949
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40663411
14Fatty acid metabolism_Homo sapiens_hsa012122.26141538
15PPAR signaling pathway_Homo sapiens_hsa033202.24403076
16Complement and coagulation cascades_Homo sapiens_hsa046102.23983138
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23565848
18Peroxisome_Homo sapiens_hsa041462.14848776
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89301689
20* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88280697
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87385182
22beta-Alanine metabolism_Homo sapiens_hsa004101.83483449
23Pyruvate metabolism_Homo sapiens_hsa006201.72691007
24Chemical carcinogenesis_Homo sapiens_hsa052041.67021836
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66467228
26Histidine metabolism_Homo sapiens_hsa003401.66243792
27Caffeine metabolism_Homo sapiens_hsa002321.62927321
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59923196
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.58517349
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.55969466
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52799404
32Selenocompound metabolism_Homo sapiens_hsa004501.50453122
33Bile secretion_Homo sapiens_hsa049761.50189719
34* Carbon metabolism_Homo sapiens_hsa012001.44664135
35Retinol metabolism_Homo sapiens_hsa008301.44501099
36Sulfur metabolism_Homo sapiens_hsa009201.44427126
37Phenylalanine metabolism_Homo sapiens_hsa003601.42073978
38Staphylococcus aureus infection_Homo sapiens_hsa051501.40810872
39Fatty acid elongation_Homo sapiens_hsa000621.39838352
40Fat digestion and absorption_Homo sapiens_hsa049751.35226984
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30843023
42* Biosynthesis of amino acids_Homo sapiens_hsa012301.25184812
43Tyrosine metabolism_Homo sapiens_hsa003501.24991337
44Steroid biosynthesis_Homo sapiens_hsa001001.23043860
45* Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19757647
46Other glycan degradation_Homo sapiens_hsa005111.19189319
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18075532
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.17427973
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16943658
50Folate biosynthesis_Homo sapiens_hsa007901.13936266
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.10747396
52Vitamin digestion and absorption_Homo sapiens_hsa049771.09716653
53Focal adhesion_Homo sapiens_hsa045101.08989099
54ABC transporters_Homo sapiens_hsa020101.07283315
55Fatty acid biosynthesis_Homo sapiens_hsa000611.05114300
56Arginine and proline metabolism_Homo sapiens_hsa003301.03260686
57Lysine degradation_Homo sapiens_hsa003100.98947102
58Glycerolipid metabolism_Homo sapiens_hsa005610.97140153
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89455802
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87401732
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.86789813
62Sulfur relay system_Homo sapiens_hsa041220.86361272
63Glutathione metabolism_Homo sapiens_hsa004800.85474239
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82019631
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80413287
66Vitamin B6 metabolism_Homo sapiens_hsa007500.76573213
67Pentose phosphate pathway_Homo sapiens_hsa000300.75468564
68Proteoglycans in cancer_Homo sapiens_hsa052050.74891802
69Adherens junction_Homo sapiens_hsa045200.72430404
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72161318
71One carbon pool by folate_Homo sapiens_hsa006700.68305648
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61473656
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61187850
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59973057
75Dilated cardiomyopathy_Homo sapiens_hsa054140.50943175
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50397342
77Fructose and mannose metabolism_Homo sapiens_hsa000510.44957881
78* Metabolic pathways_Homo sapiens_hsa011000.44513692
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.41419907
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41228518
81Insulin resistance_Homo sapiens_hsa049310.38769741
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37954648
83Pertussis_Homo sapiens_hsa051330.35914093
84Galactose metabolism_Homo sapiens_hsa000520.35642356
85Small cell lung cancer_Homo sapiens_hsa052220.35032178
86TGF-beta signaling pathway_Homo sapiens_hsa043500.34177021
87N-Glycan biosynthesis_Homo sapiens_hsa005100.34017408
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32751833
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31479604
90Tight junction_Homo sapiens_hsa045300.29185489
91AMPK signaling pathway_Homo sapiens_hsa041520.29007047
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25497634
93Prion diseases_Homo sapiens_hsa050200.21541893
94Renin-angiotensin system_Homo sapiens_hsa046140.15958882
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.14463641
96Glucagon signaling pathway_Homo sapiens_hsa049220.12907777
97Protein digestion and absorption_Homo sapiens_hsa049740.10724553
98Linoleic acid metabolism_Homo sapiens_hsa005910.08795868
99Mineral absorption_Homo sapiens_hsa049780.03558032
100Insulin signaling pathway_Homo sapiens_hsa049100.02052084
101ECM-receptor interaction_Homo sapiens_hsa04512-0.1462642
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1402945
103Amoebiasis_Homo sapiens_hsa05146-0.1387842
104Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1257226
105Hepatitis C_Homo sapiens_hsa05160-0.1223199
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1144365
107Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1040952
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0907973
109Bladder cancer_Homo sapiens_hsa05219-0.0871357
110Lysosome_Homo sapiens_hsa04142-0.0848598
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0790670
112Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0748882
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0443342
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0372584
115Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0304557
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0257120
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0145336

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