ACKR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.74672471
2regulation of cardiac muscle cell contraction (GO:0086004)5.89992207
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62697477
4synaptic vesicle exocytosis (GO:0016079)5.53161683
5synaptic vesicle maturation (GO:0016188)5.24074267
6vocalization behavior (GO:0071625)5.21065765
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20822083
8endothelial cell morphogenesis (GO:0001886)5.18297374
9glutamate secretion (GO:0014047)4.99901716
10regulation of actin filament-based movement (GO:1903115)4.98695940
11regulation of synaptic vesicle exocytosis (GO:2000300)4.82751997
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.82673297
13locomotory exploration behavior (GO:0035641)4.67022242
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65333158
15neuronal action potential propagation (GO:0019227)4.63613400
16protein localization to synapse (GO:0035418)4.61060974
17neuron cell-cell adhesion (GO:0007158)4.43169616
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.41906143
19neurotransmitter secretion (GO:0007269)4.41372823
20glomerular filtration (GO:0003094)4.30158263
21response to pheromone (GO:0019236)4.23258414
22regulation of synaptic vesicle transport (GO:1902803)4.19040478
23cellular potassium ion homeostasis (GO:0030007)4.14006489
24cerebellar granule cell differentiation (GO:0021707)4.10047915
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.08878537
26glutamate receptor signaling pathway (GO:0007215)4.05067022
27positive regulation of synapse maturation (GO:0090129)4.04404936
28regulation of glutamate receptor signaling pathway (GO:1900449)4.03114748
29potassium ion import (GO:0010107)3.99391137
30cell migration in hindbrain (GO:0021535)3.93856557
31neurotransmitter-gated ion channel clustering (GO:0072578)3.89799485
32layer formation in cerebral cortex (GO:0021819)3.88244896
33regulation of synapse structural plasticity (GO:0051823)3.87826378
34cerebellar Purkinje cell differentiation (GO:0021702)3.87418871
35synaptic transmission, glutamatergic (GO:0035249)3.84390395
36exploration behavior (GO:0035640)3.81694681
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.77696811
38sodium ion export (GO:0071436)3.77180863
39renal filtration (GO:0097205)3.75105890
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.73468284
41neuron-neuron synaptic transmission (GO:0007270)3.71524562
42cAMP biosynthetic process (GO:0006171)3.68814444
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.66772817
44neuron recognition (GO:0008038)3.63806580
45neurotransmitter transport (GO:0006836)3.62728950
46activation of protein kinase A activity (GO:0034199)3.61864135
47synaptic vesicle endocytosis (GO:0048488)3.58993057
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58902317
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58285232
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55638128
51regulation of neuronal synaptic plasticity (GO:0048168)3.53480727
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51755614
53membrane depolarization during action potential (GO:0086010)3.49032353
54proline transport (GO:0015824)3.47203460
55retina vasculature morphogenesis in camera-type eye (GO:0061299)3.46773935
56gamma-aminobutyric acid transport (GO:0015812)3.44587245
57negative regulation of endothelial cell migration (GO:0010596)3.43594050
58heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.41224214
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41195664
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40863946
61regulation of neurotransmitter secretion (GO:0046928)3.37214658
62positive regulation of calcium ion import (GO:0090280)3.35813479
63mating behavior (GO:0007617)3.34386965
64innervation (GO:0060384)3.31545843
65positive regulation of membrane potential (GO:0045838)3.30854433
66synapse assembly (GO:0007416)3.30774833
67regulation of synapse maturation (GO:0090128)3.29237079
68regulation of postsynaptic membrane potential (GO:0060078)3.28944712
69regulation of neurotransmitter levels (GO:0001505)3.25683729
70response to dietary excess (GO:0002021)3.25051850
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24040773
72regulation of voltage-gated calcium channel activity (GO:1901385)3.21115057
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.21095360
74transmission of nerve impulse (GO:0019226)3.19997301
75long-term memory (GO:0007616)3.19766923
76complement activation, classical pathway (GO:0006958)3.17035659
77cell differentiation in hindbrain (GO:0021533)3.17002183
78low-density lipoprotein particle clearance (GO:0034383)3.16964179
79dendrite morphogenesis (GO:0048813)3.16158288
80prepulse inhibition (GO:0060134)3.15190095
81axonal fasciculation (GO:0007413)3.14936832
82triglyceride catabolic process (GO:0019433)3.14905325
83regulation of vesicle fusion (GO:0031338)3.12327937
84membrane depolarization (GO:0051899)3.12135529
85regulation of neurotransmitter transport (GO:0051588)3.12048653
86negative regulation of dendrite morphogenesis (GO:0050774)3.10110492
87postsynaptic membrane organization (GO:0001941)3.07756205
88membrane hyperpolarization (GO:0060081)3.06626179
89neuromuscular process controlling posture (GO:0050884)3.05408559
90dendritic spine morphogenesis (GO:0060997)3.03963681
91positive regulation of potassium ion transmembrane transport (GO:1901381)3.01047208
92regulation of sequestering of triglyceride (GO:0010889)2.99299987
93cell communication by electrical coupling (GO:0010644)2.99158553
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98969743
95neuromuscular process controlling balance (GO:0050885)2.98510900
96positive regulation of receptor recycling (GO:0001921)2.97872787
97negative regulation of microtubule polymerization (GO:0031115)2.97431216
98lymphangiogenesis (GO:0001946)2.97368677
99presynaptic membrane assembly (GO:0097105)2.97028680
100auditory behavior (GO:0031223)2.96764699
101regulation of excretion (GO:0044062)2.96446631
102synaptic transmission (GO:0007268)2.95294109
103long-term synaptic potentiation (GO:0060291)2.93191110
104neuron remodeling (GO:0016322)2.93095457
105regulation of dendritic spine morphogenesis (GO:0061001)2.91784295
106regulation of synaptic plasticity (GO:0048167)2.90815584
107cGMP-mediated signaling (GO:0019934)2.90776847
108calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89042556
109presynaptic membrane organization (GO:0097090)2.88004806
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87614447
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87112365
112lymph vessel development (GO:0001945)2.86812210
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86506581
114response to auditory stimulus (GO:0010996)2.84653342
115acylglycerol catabolic process (GO:0046464)2.84506730
116neutral lipid catabolic process (GO:0046461)2.84506730
117negative regulation of dendrite development (GO:2000171)2.83835307
118long term synaptic depression (GO:0060292)2.83785657
119potassium ion homeostasis (GO:0055075)2.83418372
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82249052
121cellular response to cAMP (GO:0071320)2.77292172
122complement activation (GO:0006956)2.74529852
123negative regulation of epithelial cell migration (GO:0010633)2.74370247
124renal absorption (GO:0070293)2.73752468
125ovulation from ovarian follicle (GO:0001542)2.73594273
126negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.65943858
127cyclic purine nucleotide metabolic process (GO:0052652)2.62920999
128positive regulation of urine volume (GO:0035810)2.62098740
129cellular response to epinephrine stimulus (GO:0071872)2.60542802
130regulation of lipoprotein metabolic process (GO:0050746)2.59428897
131decidualization (GO:0046697)2.58929990
132regulation of macrophage chemotaxis (GO:0010758)2.56510313
133negative regulation of calcium ion transport (GO:0051926)2.55500552
134neuronal ion channel clustering (GO:0045161)2.54864436
135transcytosis (GO:0045056)2.53316230
136barbed-end actin filament capping (GO:0051016)2.50862887
137polyol transport (GO:0015791)2.50454387
138endocrine hormone secretion (GO:0060986)2.48729393
139endothelium development (GO:0003158)2.45130195
140cyclic nucleotide biosynthetic process (GO:0009190)2.45116232
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44932921
142endothelial cell chemotaxis (GO:0035767)2.43654373
143protein heterotrimerization (GO:0070208)2.43478135
144extracellular fibril organization (GO:0043206)2.40117037
145cellular response to monoamine stimulus (GO:0071868)2.38874344
146cellular response to catecholamine stimulus (GO:0071870)2.38874344
147positive regulation of vascular permeability (GO:0043117)2.37319037
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35133908
149adhesion of symbiont to host cell (GO:0044650)2.33220628
150virion attachment to host cell (GO:0019062)2.33220628
151cAMP metabolic process (GO:0046058)2.33088429
152glycerolipid catabolic process (GO:0046503)2.31834997
153regulation of glycogen (starch) synthase activity (GO:2000465)2.30963284
154extracellular matrix assembly (GO:0085029)2.29673917
155protein activation cascade (GO:0072376)2.29296259
156regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.29046960
157protein targeting to plasma membrane (GO:0072661)2.25956578
158actin filament capping (GO:0051693)2.23933452
159positive regulation of Rap GTPase activity (GO:0032854)2.22992635
160positive regulation of respiratory burst (GO:0060267)2.22336962
161peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.22271302
162regulation of calcium ion import (GO:0090279)2.20657676
163cellular sodium ion homeostasis (GO:0006883)2.20569592
164regulation of cardiac muscle contraction (GO:0055117)2.18981585
165regulation of vasculogenesis (GO:2001212)2.18127332
166blood vessel maturation (GO:0001955)2.17829213
167positive regulation of chemokine secretion (GO:0090197)2.15443427
168negative regulation of gluconeogenesis (GO:0045721)2.13904219
169gas transport (GO:0015669)2.13394301
170membrane repolarization (GO:0086009)2.13043408
171regulation of p38MAPK cascade (GO:1900744)2.12863647
172cellular response to nitric oxide (GO:0071732)2.12518576
173detection of calcium ion (GO:0005513)2.12351929
174regulation of Rap GTPase activity (GO:0032317)2.11870949
175regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.11747742
176negative regulation of actin filament bundle assembly (GO:0032232)2.10658438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11613780
2GBX2_23144817_ChIP-Seq_PC3_Human3.47911913
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23577249
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22570714
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97976553
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83605030
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82732701
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76689400
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76689400
10REST_21632747_ChIP-Seq_MESCs_Mouse2.64534469
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64076727
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62759841
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61981915
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60168551
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58890584
16DROSHA_22980978_ChIP-Seq_HELA_Human2.47510021
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.46209561
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41069317
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38588967
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.38426397
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.21566959
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.20074252
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19646992
24AR_21572438_ChIP-Seq_LNCaP_Human2.17661630
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12208578
26TAF15_26573619_Chip-Seq_HEK293_Human2.10761353
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.08961643
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.06688583
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99223258
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85990138
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75172101
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.74403340
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72349851
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72040522
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71250869
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.70595576
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67859507
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66834062
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66624939
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63727132
41SMAD4_21799915_ChIP-Seq_A2780_Human1.60490596
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.58614441
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54364857
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54015533
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53834963
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.53107550
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49135175
48P300_19829295_ChIP-Seq_ESCs_Human1.46301898
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41520589
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41491794
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.38130707
52GATA1_22025678_ChIP-Seq_K562_Human1.37453071
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.36475999
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35727995
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29923187
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.29374376
57AR_25329375_ChIP-Seq_VCAP_Human1.28682675
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.26324123
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25887337
60ZNF274_21170338_ChIP-Seq_K562_Hela1.25639530
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25439965
62CLOCK_20551151_ChIP-Seq_293T_Human1.25235660
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24875980
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23644975
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.23242939
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23139386
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22976053
68EGR1_19032775_ChIP-ChIP_M12_Human1.22438388
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21684762
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.18427506
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17454381
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.17144558
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.15661171
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.15661171
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15108208
76STAT3_23295773_ChIP-Seq_U87_Human1.14516288
77RNF2_27304074_Chip-Seq_NSC_Mouse1.14383599
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14224152
79AR_19668381_ChIP-Seq_PC3_Human1.13279693
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12529293
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.11588735
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10962078
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10911435
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09883174
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08441889
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06292613
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05668146
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04772317
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04634664
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04401179
91LXR_22292898_ChIP-Seq_THP-1_Human1.03559000
92IGF1R_20145208_ChIP-Seq_DFB_Human1.02816850
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.02457363
94KDM2B_26808549_Chip-Seq_K562_Human1.02211280
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01780882
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00936275
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00588437
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00574206
99AHR_22903824_ChIP-Seq_MCF-7_Human1.00111014
100GATA1_19941826_ChIP-Seq_K562_Human0.99758736
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.99047694
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98722852
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98288713
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98175440
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95457151
106TCF4_23295773_ChIP-Seq_U87_Human0.95372625
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94230401
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93352366
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.93275556
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.93101754
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91944382
112RUNX2_22187159_ChIP-Seq_PCA_Human0.91750276
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.91375747
114CJUN_26792858_Chip-Seq_BT549_Human0.91302259
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91104004
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90616567
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.90177412
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.89544926
119RXR_22108803_ChIP-Seq_LS180_Human0.89505016
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89202181
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89061716
122SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87642299
123VDR_22108803_ChIP-Seq_LS180_Human0.87636588
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87017666
125BCAT_22108803_ChIP-Seq_LS180_Human0.85682369
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84753160
127ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84446935
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83945132
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83700179
130ER_23166858_ChIP-Seq_MCF-7_Human0.83336182
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.82491141
132RXR_22158963_ChIP-Seq_LIVER_Mouse0.82230457
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81975285
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81975285
135CTCF_27219007_Chip-Seq_Bcells_Human0.81300050
136JUN_21703547_ChIP-Seq_K562_Human0.81106594
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80747392
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.80542120
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80467324
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80060985
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78799472
142KDM2B_26808549_Chip-Seq_DND41_Human0.78249769
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78171922
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.78171836
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77805937
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.75148749
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.74257243
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.74156437
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73296067
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73057582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.35752694
2MP0003880_abnormal_central_pattern4.62878271
3MP0005670_abnormal_white_adipose4.28908072
4MP0003635_abnormal_synaptic_transmissio3.74505639
5MP0003011_delayed_dark_adaptation3.57015448
6MP0004270_analgesia3.47872281
7MP0001968_abnormal_touch/_nociception3.28112561
8MP0009046_muscle_twitch3.21737191
9MP0009745_abnormal_behavioral_response2.99260308
10MP0002735_abnormal_chemical_nociception2.98662903
11MP0002063_abnormal_learning/memory/cond2.87709839
12MP0002734_abnormal_mechanical_nocicepti2.85311531
13MP0002064_seizures2.83053518
14MP0002736_abnormal_nociception_after2.75499124
15MP0002272_abnormal_nervous_system2.62812004
16MP0005275_abnormal_skin_tensile2.57146108
17MP0002572_abnormal_emotion/affect_behav2.47657390
18MP0005423_abnormal_somatic_nervous2.45415399
19MP0002067_abnormal_sensory_capabilities2.33729561
20MP0005666_abnormal_adipose_tissue2.30054565
21MP0010368_abnormal_lymphatic_system2.29659642
22MP0000013_abnormal_adipose_tissue2.29643311
23MP0001486_abnormal_startle_reflex2.24207657
24MP0002971_abnormal_brown_adipose2.23161517
25MP0006276_abnormal_autonomic_nervous2.21103968
26MP0006138_congestive_heart_failure2.21014192
27MP0001501_abnormal_sleep_pattern2.16364931
28MP0001440_abnormal_grooming_behavior2.15186288
29MP0002184_abnormal_innervation2.09597954
30MP0002733_abnormal_thermal_nociception2.07116506
31MP0008438_abnormal_cutaneous_collagen2.01583530
32MP0005503_abnormal_tendon_morphology2.00102947
33MP0001970_abnormal_pain_threshold1.99205855
34MP0004147_increased_porphyrin_level1.97478776
35MP0008569_lethality_at_weaning1.95109991
36MP0004858_abnormal_nervous_system1.93871020
37MP0008004_abnormal_stomach_pH1.93237567
38MP0005551_abnormal_eye_electrophysiolog1.82831356
39MP0001984_abnormal_olfaction1.80755677
40MP0003724_increased_susceptibility_to1.80468091
41MP0005375_adipose_tissue_phenotype1.79059983
42MP0000778_abnormal_nervous_system1.76095461
43MP0002822_catalepsy1.76024631
44MP0001879_abnormal_lymphatic_vessel1.74372675
45MP0002876_abnormal_thyroid_physiology1.70624225
46MP0004924_abnormal_behavior1.69041741
47MP0005386_behavior/neurological_phenoty1.69041741
48MP0004215_abnormal_myocardial_fiber1.68626945
49MP0003279_aneurysm1.61654942
50MP0004811_abnormal_neuron_physiology1.61234262
51MP0002557_abnormal_social/conspecific_i1.59093757
52MP0003329_amyloid_beta_deposits1.58907588
53MP0000955_abnormal_spinal_cord1.55871098
54MP0004145_abnormal_muscle_electrophysio1.51212305
55MP0002909_abnormal_adrenal_gland1.48439524
56MP0000343_altered_response_to1.48160644
57MP0001502_abnormal_circadian_rhythm1.46934377
58MP0003633_abnormal_nervous_system1.43118192
59MP0009115_abnormal_fat_cell1.40655208
60MP0001958_emphysema1.40375013
61MP0003828_pulmonary_edema1.39638828
62MP0002882_abnormal_neuron_morphology1.39524483
63MP0009379_abnormal_foot_pigmentation1.36717906
64MP0001188_hyperpigmentation1.35734110
65MP0003879_abnormal_hair_cell1.34806593
66MP0002066_abnormal_motor_capabilities/c1.34012470
67MP0004142_abnormal_muscle_tone1.28700358
68MP0006054_spinal_hemorrhage1.28143090
69MP0001544_abnormal_cardiovascular_syste1.27973592
70MP0005385_cardiovascular_system_phenoty1.27973592
71MP0001529_abnormal_vocalization1.27347219
72MP0010329_abnormal_lipoprotein_level1.22476036
73MP0002295_abnormal_pulmonary_circulatio1.19874307
74MP0003959_abnormal_lean_body1.19598029
75MP0002933_joint_inflammation1.18248349
76MP0005448_abnormal_energy_balance1.18165316
77MP0005409_darkened_coat_color1.17662343
78MP0000249_abnormal_blood_vessel1.17480429
79MP0003045_fibrosis1.16634597
80MP0003631_nervous_system_phenotype1.15810436
81MP0002108_abnormal_muscle_morphology1.13456455
82MP0009780_abnormal_chondrocyte_physiolo1.12396380
83MP0003075_altered_response_to1.12070680
84MP0000767_abnormal_smooth_muscle1.10802599
85MP0002229_neurodegeneration1.08595000
86MP0005166_decreased_susceptibility_to1.07423678
87MP0005083_abnormal_biliary_tract1.06301938
88MP0000751_myopathy1.05261082
89MP0005334_abnormal_fat_pad1.05188639
90MP0002090_abnormal_vision1.02135780
91MP0004085_abnormal_heartbeat1.01180257
92MP0002638_abnormal_pupillary_reflex1.01030237
93MP0003303_peritoneal_inflammation1.00713658
94MP0000003_abnormal_adipose_tissue1.00058097
95MP0001905_abnormal_dopamine_level0.99920137
96MP0008874_decreased_physiological_sensi0.99649932
97MP0005620_abnormal_muscle_contractility0.98513684
98MP0004885_abnormal_endolymph0.98197875
99MP0002152_abnormal_brain_morphology0.96959899
100MP0001851_eye_inflammation0.96680851
101MP0002972_abnormal_cardiac_muscle0.95044053
102MP0004742_abnormal_vestibular_system0.95005030
103MP0008872_abnormal_physiological_respon0.94869983
104MP0002752_abnormal_somatic_nervous0.91703811
105MP0006072_abnormal_retinal_apoptosis0.90120923
106MP0005167_abnormal_blood-brain_barrier0.88139487
107MP0005394_taste/olfaction_phenotype0.88118215
108MP0005499_abnormal_olfactory_system0.88118215
109MP0004084_abnormal_cardiac_muscle0.87490125
110MP0003122_maternal_imprinting0.86865954
111MP0002118_abnormal_lipid_homeostasis0.86014685
112MP0005646_abnormal_pituitary_gland0.83697513
113MP0003634_abnormal_glial_cell0.83234651
114MP0005165_increased_susceptibility_to0.83133809
115MP0003787_abnormal_imprinting0.82942823
116MP0002970_abnormal_white_adipose0.81323674
117MP0002133_abnormal_respiratory_system0.81016316
118MP0005388_respiratory_system_phenotype0.81016316
119MP0010386_abnormal_urinary_bladder0.80592989
120MP0003948_abnormal_gas_homeostasis0.79900751
121MP0000747_muscle_weakness0.79602605
122MP0004510_myositis0.79567969
123MP0002069_abnormal_eating/drinking_beha0.74988606
124MP0000230_abnormal_systemic_arterial0.74536777
125MP0003632_abnormal_nervous_system0.74130830
126MP0003868_abnormal_feces_composition0.74079973
127MP0000749_muscle_degeneration0.73996484
128MP0000604_amyloidosis0.73236304
129MP0005253_abnormal_eye_physiology0.71962758
130MP0004087_abnormal_muscle_fiber0.71401994
131MP0002332_abnormal_exercise_endurance0.70318017
132MP0000920_abnormal_myelination0.70268913
133MP0005645_abnormal_hypothalamus_physiol0.69315634
134MP0004130_abnormal_muscle_cell0.68685686
135MP0005535_abnormal_body_temperature0.67979209
136MP0001177_atelectasis0.67398457
137MP0001963_abnormal_hearing_physiology0.66872406
138MP0005623_abnormal_meninges_morphology0.63507739
139MP0005195_abnormal_posterior_eye0.62967572
140MP0003137_abnormal_impulse_conducting0.62462463
141MP0004233_abnormal_muscle_weight0.59490763
142MP0003690_abnormal_glial_cell0.59121142
143MP0005595_abnormal_vascular_smooth0.55136394
144MP0002089_abnormal_postnatal_growth/wei0.54543536
145MP0004484_altered_response_of0.54205762
146MP0004036_abnormal_muscle_relaxation0.53934249
147MP0002082_postnatal_lethality0.53914228
148MP0010770_preweaning_lethality0.53914228

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.54638835
2Myokymia (HP:0002411)6.28576367
3Focal seizures (HP:0007359)5.19279017
4Visual hallucinations (HP:0002367)5.03453188
5Febrile seizures (HP:0002373)5.02043234
6Epileptic encephalopathy (HP:0200134)4.98712237
7Atonic seizures (HP:0010819)4.84329549
8Complement deficiency (HP:0004431)4.74800872
9Systemic lupus erythematosus (HP:0002725)4.71386658
10Progressive cerebellar ataxia (HP:0002073)4.66719077
11Muscle fiber splitting (HP:0003555)4.22834620
12Action tremor (HP:0002345)4.19545243
13Abnormality of complement system (HP:0005339)4.19168919
14Absence seizures (HP:0002121)4.15730085
15Supranuclear gaze palsy (HP:0000605)3.72133410
16Pigmentary retinal degeneration (HP:0001146)3.71365211
17Generalized tonic-clonic seizures (HP:0002069)3.65668817
18Dialeptic seizures (HP:0011146)3.61422206
19Oligomenorrhea (HP:0000876)3.49613289
20Central scotoma (HP:0000603)3.46918090
21Aortic aneurysm (HP:0004942)3.38380292
22Cerebral aneurysm (HP:0004944)3.32945638
23Gaze-evoked nystagmus (HP:0000640)3.26662444
24Amyloidosis (HP:0011034)3.24752753
25Hyporeflexia of lower limbs (HP:0002600)3.24007229
26Congenital stationary night blindness (HP:0007642)3.23838996
27Glomerulonephritis (HP:0000099)3.21514056
28Vascular tortuosity (HP:0004948)3.19271859
29Broad-based gait (HP:0002136)3.18662041
30Difficulty running (HP:0009046)3.12321282
31Acanthosis nigricans (HP:0000956)3.11932100
32Depression (HP:0000716)3.04137704
33Mutism (HP:0002300)3.00824867
34Obstructive sleep apnea (HP:0002870)3.00549111
35Hypertriglyceridemia (HP:0002155)3.00517412
36Abnormality of the foot musculature (HP:0001436)2.99968708
37Ankle clonus (HP:0011448)2.94539243
38Hyperventilation (HP:0002883)2.93911579
39Foot dorsiflexor weakness (HP:0009027)2.92790305
40Dysdiadochokinesis (HP:0002075)2.92173429
41Polycythemia (HP:0001901)2.90531476
42Poor eye contact (HP:0000817)2.90283794
43Arterial tortuosity (HP:0005116)2.89264322
44Truncal ataxia (HP:0002078)2.89140348
45Increased connective tissue (HP:0009025)2.85952166
46Anxiety (HP:0000739)2.82686595
47Abnormality of macular pigmentation (HP:0008002)2.82025541
48Amblyopia (HP:0000646)2.81961942
49Abnormality of the lower motor neuron (HP:0002366)2.81590622
50Pheochromocytoma (HP:0002666)2.80590415
51Bundle branch block (HP:0011710)2.78739413
52Limb dystonia (HP:0002451)2.78079220
53Termporal pattern (HP:0011008)2.75986815
54Insidious onset (HP:0003587)2.75986815
55Increased variability in muscle fiber diameter (HP:0003557)2.72185103
56Abnormal eating behavior (HP:0100738)2.71697852
57Impaired social interactions (HP:0000735)2.70038217
58Abnormal social behavior (HP:0012433)2.70038217
59Nonimmune hydrops fetalis (HP:0001790)2.69418576
60Dysmetria (HP:0001310)2.69175181
61Hemiparesis (HP:0001269)2.67930141
62Scanning speech (HP:0002168)2.63844117
63Axonal loss (HP:0003447)2.58622201
64Hemiplegia (HP:0002301)2.57731841
65Impaired smooth pursuit (HP:0007772)2.57620809
66Striae distensae (HP:0001065)2.56269030
67Growth hormone excess (HP:0000845)2.56162257
68Impaired vibration sensation in the lower limbs (HP:0002166)2.54167733
69Urinary bladder sphincter dysfunction (HP:0002839)2.53936093
70Abnormality of the corticospinal tract (HP:0002492)2.52880204
71Sudden death (HP:0001699)2.47304223
72Genetic anticipation (HP:0003743)2.46534067
73Abnormality of binocular vision (HP:0011514)2.43264842
74Diplopia (HP:0000651)2.43264842
75Neuroendocrine neoplasm (HP:0100634)2.43079194
76Protrusio acetabuli (HP:0003179)2.42388393
77Fetal akinesia sequence (HP:0001989)2.41245587
78Abnormality of ocular smooth pursuit (HP:0000617)2.40291074
79Drooling (HP:0002307)2.40172294
80Excessive salivation (HP:0003781)2.40172294
81Dysmetric saccades (HP:0000641)2.39196811
82Torticollis (HP:0000473)2.38891478
83Scotoma (HP:0000575)2.37929035
84Type 1 muscle fiber predominance (HP:0003803)2.36360324
85Prolonged QT interval (HP:0001657)2.32571515
86Peripheral hypomyelination (HP:0007182)2.32343573
87Polyphagia (HP:0002591)2.32151228
88Hyperlipoproteinemia (HP:0010980)2.31358445
89Abnormal atrioventricular conduction (HP:0005150)2.29208427
90Epileptiform EEG discharges (HP:0011182)2.28725070
91Abnormality of skeletal muscle fiber size (HP:0012084)2.28660734
92Syncope (HP:0001279)2.27155265
93Nephritis (HP:0000123)2.26239052
94Spastic gait (HP:0002064)2.26019571
95Focal dystonia (HP:0004373)2.25430863
96Heart block (HP:0012722)2.24742090
97Cholecystitis (HP:0001082)2.24438580
98Abnormal gallbladder physiology (HP:0012438)2.24438580
99Primary atrial arrhythmia (HP:0001692)2.24312170
100Agitation (HP:0000713)2.24033210
101Neurofibrillary tangles (HP:0002185)2.23917821
102EEG with generalized epileptiform discharges (HP:0011198)2.23707617
103Atrial fibrillation (HP:0005110)2.22671028
104Intention tremor (HP:0002080)2.20901700
105Progressive inability to walk (HP:0002505)2.18283211
106Ventricular fibrillation (HP:0001663)2.17860872
107Status epilepticus (HP:0002133)2.16532357
108Incomplete penetrance (HP:0003829)2.15531705
109Broad metatarsal (HP:0001783)2.14690295
110Mildly elevated creatine phosphokinase (HP:0008180)2.12876779
111Supraventricular arrhythmia (HP:0005115)2.12560872
112Pulmonary artery stenosis (HP:0004415)2.12420956
113Supraventricular tachycardia (HP:0004755)2.12298155
114Hypoventilation (HP:0002791)2.10777764
115Craniofacial dystonia (HP:0012179)2.10524290
116Postural instability (HP:0002172)2.10491920
117Cerebral inclusion bodies (HP:0100314)2.10337416
118Failure to thrive in infancy (HP:0001531)2.10213614
119Abnormality of the heme biosynthetic pathway (HP:0010472)2.10160624
120Urinary urgency (HP:0000012)2.09913212
121Absent speech (HP:0001344)2.09344500
122Spinal canal stenosis (HP:0003416)2.08827773
123Steppage gait (HP:0003376)2.08319053
124Segmental peripheral demyelination/remyelination (HP:0003481)2.07311266
125Papilledema (HP:0001085)2.06744704
126Aortic dissection (HP:0002647)2.06120291
127Ulnar claw (HP:0001178)2.05332799
128Asymmetric septal hypertrophy (HP:0001670)2.03332880
129Overgrowth (HP:0001548)2.03106365
130Hypsarrhythmia (HP:0002521)2.02764621
131Amyotrophic lateral sclerosis (HP:0007354)2.01494305
132Stereotypic behavior (HP:0000733)2.01283324
133Bradykinesia (HP:0002067)2.00810996
134Increased IgE level (HP:0003212)2.00676257
135Severe visual impairment (HP:0001141)1.99610275
136Metaphyseal dysplasia (HP:0100255)1.97306658
137Inability to walk (HP:0002540)1.96393609
138Lower limb muscle weakness (HP:0007340)1.96194437
139Onion bulb formation (HP:0003383)1.95174988
140Bone cyst (HP:0012062)1.93551568
141Atelectasis (HP:0100750)1.93496653
142Hypercortisolism (HP:0001578)1.91667230
143Spontaneous hematomas (HP:0007420)1.91067731
144Morphological abnormality of the pyramidal tract (HP:0002062)1.90877615
145Recurrent gram-negative bacterial infections (HP:0005420)1.89450656
146Rapidly progressive (HP:0003678)1.89304539
147Neck muscle weakness (HP:0000467)1.88649745
148Gait imbalance (HP:0002141)1.88416727
149Cerebral hemorrhage (HP:0001342)1.88025266
150Absent eyebrow (HP:0002223)1.88014584
151EMG: neuropathic changes (HP:0003445)1.87481185
152Distal lower limb muscle weakness (HP:0009053)1.86780871
153Malnutrition (HP:0004395)1.86710631
154Myotonia (HP:0002486)1.86028235
155Postural tremor (HP:0002174)1.85906095
156Atrioventricular block (HP:0001678)1.85620295
157Retinal dysplasia (HP:0007973)1.85046025
158Decreased central vision (HP:0007663)1.84658694
159Choroideremia (HP:0001139)1.84450798
160Wormian bones (HP:0002645)1.83673170
161Stroke (HP:0001297)1.83494841
162Impaired pain sensation (HP:0007328)1.82925285
163Abnormality of pain sensation (HP:0010832)1.82925285
164Hammertoe (HP:0001765)1.82858706
165Bulbar palsy (HP:0001283)1.82738439
166Generalized myoclonic seizures (HP:0002123)1.82404536
167Gait ataxia (HP:0002066)1.82154909
168Abnormal EKG (HP:0003115)1.81775031
169Specific learning disability (HP:0001328)1.81232483
170Abnormal hair whorl (HP:0010721)1.80432764
171Persistence of primary teeth (HP:0006335)1.80322802
172Lower limb amyotrophy (HP:0007210)1.78951083
173Lipoatrophy (HP:0100578)1.77299193
174Ventricular arrhythmia (HP:0004308)1.77221798
175Nuclear cataract (HP:0100018)1.75753548
176Ileus (HP:0002595)1.75120443
177Aneurysm (HP:0002617)1.72493299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.78474628
2NTRK33.62110478
3MARK13.39772716
4MAP3K93.04522726
5EPHA32.99435290
6MAP3K42.91784003
7MINK12.88224790
8TIE12.71350470
9CASK2.70605207
10DAPK22.69646165
11MAP2K72.39448871
12EPHB22.35538839
13MAP3K122.31128921
14EPHA42.29578081
15PAK62.10571835
16MAP2K42.02833433
17MYLK2.01240122
18CAMKK21.90574912
19ERN11.81527787
20MAPK131.69435768
21GRK51.67823948
22DDR21.64657715
23EPHB11.63191380
24KSR21.62507721
25CAMKK11.57906387
26SIK21.54170887
27NTRK11.53103889
28NTRK21.53010974
29MAP3K61.51734892
30PLK21.47533826
31PRPF4B1.43501013
32PHKG21.38860224
33PHKG11.38860224
34FES1.37112329
35CDK51.35407926
36PNCK1.33749680
37PTK21.29320511
38DAPK11.27327315
39PDGFRA1.18195599
40PRKCG1.16774476
41ITK1.15313486
42SGK4941.13681009
43SGK2231.13681009
44TEC1.13304429
45NLK1.10827855
46RIPK11.08191577
47ABL21.07210150
48CAMK41.06710356
49PTK2B1.04703231
50CDK191.04320477
51TTN1.02572508
52SIK31.01889282
53RET0.99197387
54CAMK2A0.98673116
55CDC42BPA0.97532931
56KSR10.96345981
57PRKD30.95736841
58PRKAA20.93183372
59TNIK0.93048601
60MAPK40.92767772
61MAPKAPK30.92431516
62FGFR40.91967314
63TRPM70.91809800
64STK380.90026205
65SGK20.88727231
66LATS20.87808843
67MAPK70.87404113
68TBK10.86236091
69PRKCH0.85008245
70RIPK40.84079752
71DYRK1A0.83824392
72PRKD10.83541753
73MAP3K20.83307237
74DMPK0.83291103
75CDK140.81746779
76MAPK120.81274746
77ARAF0.81023708
78CDK180.80835360
79TGFBR10.79911150
80TRIB30.79094192
81FER0.77985500
82UHMK10.77710927
83CDK150.77197041
84PDGFRB0.76875092
85NEK10.76410189
86TYRO30.76191619
87PKN10.75062077
88GRK70.74968458
89BMPR20.73049118
90ROCK10.70787623
91CSNK1G20.70573580
92MAP2K10.69708794
93TAOK10.66140451
94TESK10.65751037
95CDK11A0.65710551
96CAMK10.63938072
97CSK0.63649193
98ERBB30.63513018
99MAPK100.62750593
100CAMK1G0.61235864
101LMTK20.61180429
102STK110.60422196
103HIPK20.60114486
104SGK30.59728577
105PINK10.59126683
106CAMK2B0.59055624
107WNK10.58089963
108TYK20.57782402
109EEF2K0.57624126
110AKT30.55969261
111PRKCE0.55842086
112ACVR1B0.54536763
113SIK10.54054434
114STK390.53467519
115OXSR10.52247724
116PRKCZ0.50671999
117PRKAA10.50452323
118SGK10.49909831
119GRK10.49876579
120PRKG10.49258730
121TNK20.48779687
122KIT0.48538698
123FGFR30.48387998
124PRKACG0.48362372
125MARK20.47713759
126PDPK10.47090925
127PRKG20.46840634
128MAP3K130.46500160
129RPS6KA20.45882081
130MAP3K10.45579695
131PAK30.44924147
132NME10.44858942
133JAK10.43858103
134CAMK2G0.43690651
135CAMK2D0.41690761
136CCNB10.41454368
137SCYL20.40727388
138JAK20.40726462
139ADRBK10.39500207
140RPS6KA30.36781470
141FYN0.34907084
142TGFBR20.32634798
143PRKACA0.32498876
144SRC0.31238890
145ROCK20.30765723

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.84274547
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70705283
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83403054
4GABAergic synapse_Homo sapiens_hsa047272.78654486
5Circadian entrainment_Homo sapiens_hsa047132.60157660
6Olfactory transduction_Homo sapiens_hsa047402.57653673
7Morphine addiction_Homo sapiens_hsa050322.51999770
8Glutamatergic synapse_Homo sapiens_hsa047242.50915742
9Long-term potentiation_Homo sapiens_hsa047202.30786235
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22123130
11Amphetamine addiction_Homo sapiens_hsa050312.08184077
12Dopaminergic synapse_Homo sapiens_hsa047282.06036399
13Salivary secretion_Homo sapiens_hsa049702.05615956
14Taste transduction_Homo sapiens_hsa047421.98972891
15Cholinergic synapse_Homo sapiens_hsa047251.94697017
16Insulin secretion_Homo sapiens_hsa049111.91950243
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.91207867
18PPAR signaling pathway_Homo sapiens_hsa033201.87220477
19Collecting duct acid secretion_Homo sapiens_hsa049661.85480587
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81991068
21Serotonergic synapse_Homo sapiens_hsa047261.71865395
22Renin secretion_Homo sapiens_hsa049241.71575052
23Long-term depression_Homo sapiens_hsa047301.67363041
24Phototransduction_Homo sapiens_hsa047441.66163269
25Gastric acid secretion_Homo sapiens_hsa049711.65505007
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62643987
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57657635
28Oxytocin signaling pathway_Homo sapiens_hsa049211.57356658
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54382863
30Cocaine addiction_Homo sapiens_hsa050301.49517582
31Fatty acid biosynthesis_Homo sapiens_hsa000611.41145113
32Calcium signaling pathway_Homo sapiens_hsa040201.40024043
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34755231
34Glycerolipid metabolism_Homo sapiens_hsa005611.32755170
35Gap junction_Homo sapiens_hsa045401.31210790
36Phenylalanine metabolism_Homo sapiens_hsa003601.28871375
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26065863
38GnRH signaling pathway_Homo sapiens_hsa049121.25594293
39Histidine metabolism_Homo sapiens_hsa003401.22615604
40Cardiac muscle contraction_Homo sapiens_hsa042601.20394783
41Axon guidance_Homo sapiens_hsa043601.18661271
42Staphylococcus aureus infection_Homo sapiens_hsa051501.18522834
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17772919
44Complement and coagulation cascades_Homo sapiens_hsa046101.17321511
45cAMP signaling pathway_Homo sapiens_hsa040241.16126407
46African trypanosomiasis_Homo sapiens_hsa051431.09109414
47Type II diabetes mellitus_Homo sapiens_hsa049301.08095710
48* Malaria_Homo sapiens_hsa051441.07978930
49Fat digestion and absorption_Homo sapiens_hsa049751.04704064
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01078404
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.00614730
52Mineral absorption_Homo sapiens_hsa049781.00199027
53Estrogen signaling pathway_Homo sapiens_hsa049150.99173394
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99065212
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97604412
56Vibrio cholerae infection_Homo sapiens_hsa051100.94572242
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94540595
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93375307
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92249910
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89796274
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88555422
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.88486397
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.87654759
64ECM-receptor interaction_Homo sapiens_hsa045120.84599914
65Protein digestion and absorption_Homo sapiens_hsa049740.83006981
66Pancreatic secretion_Homo sapiens_hsa049720.82608655
67Melanogenesis_Homo sapiens_hsa049160.81433629
68AMPK signaling pathway_Homo sapiens_hsa041520.79977941
69Thyroid hormone synthesis_Homo sapiens_hsa049180.77317200
70Alzheimers disease_Homo sapiens_hsa050100.76312005
71ErbB signaling pathway_Homo sapiens_hsa040120.75921528
72Bile secretion_Homo sapiens_hsa049760.74595416
73Glioma_Homo sapiens_hsa052140.73891001
74Fatty acid degradation_Homo sapiens_hsa000710.72902905
75Oocyte meiosis_Homo sapiens_hsa041140.72791124
76Dorso-ventral axis formation_Homo sapiens_hsa043200.71936830
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70522036
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.70046530
79Oxidative phosphorylation_Homo sapiens_hsa001900.69870532
80Focal adhesion_Homo sapiens_hsa045100.69347419
81Arginine biosynthesis_Homo sapiens_hsa002200.68414759
82Dilated cardiomyopathy_Homo sapiens_hsa054140.67792214
83Pertussis_Homo sapiens_hsa051330.65954662
84Renin-angiotensin system_Homo sapiens_hsa046140.65864742
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.64245576
86Chemokine signaling pathway_Homo sapiens_hsa040620.63252008
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62662782
88Circadian rhythm_Homo sapiens_hsa047100.61806562
89MAPK signaling pathway_Homo sapiens_hsa040100.60660010
90Ras signaling pathway_Homo sapiens_hsa040140.59897130
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59386140
92Tight junction_Homo sapiens_hsa045300.58309741
93Parkinsons disease_Homo sapiens_hsa050120.57539005
94Rap1 signaling pathway_Homo sapiens_hsa040150.57537527
95beta-Alanine metabolism_Homo sapiens_hsa004100.57333219
96Adherens junction_Homo sapiens_hsa045200.56291253
97Linoleic acid metabolism_Homo sapiens_hsa005910.55830881
98Arachidonic acid metabolism_Homo sapiens_hsa005900.55467133
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55393722
100Tyrosine metabolism_Homo sapiens_hsa003500.54438810
101Arginine and proline metabolism_Homo sapiens_hsa003300.54060538
102Alcoholism_Homo sapiens_hsa050340.50624080
103VEGF signaling pathway_Homo sapiens_hsa043700.50571939
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49536347
105Choline metabolism in cancer_Homo sapiens_hsa052310.48735353
106Amoebiasis_Homo sapiens_hsa051460.47459356
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.46384040
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45816892
109Ether lipid metabolism_Homo sapiens_hsa005650.44142117
110Asthma_Homo sapiens_hsa053100.42255904
111ABC transporters_Homo sapiens_hsa020100.41299550
112Glucagon signaling pathway_Homo sapiens_hsa049220.40997170
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40839011
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39715948
115Inositol phosphate metabolism_Homo sapiens_hsa005620.39000303
116Ovarian steroidogenesis_Homo sapiens_hsa049130.38991395
117Endocytosis_Homo sapiens_hsa041440.38910418
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.38120396
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37264204
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37200721
121Renal cell carcinoma_Homo sapiens_hsa052110.35502857
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35446870
123Insulin signaling pathway_Homo sapiens_hsa049100.35339879
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33853944
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33549457
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33487997
127Rheumatoid arthritis_Homo sapiens_hsa053230.33431372
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33144512
129Huntingtons disease_Homo sapiens_hsa050160.31409808
130Prion diseases_Homo sapiens_hsa050200.30785853
131mTOR signaling pathway_Homo sapiens_hsa041500.29485017
132Endometrial cancer_Homo sapiens_hsa052130.28147877
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27858263
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27805364
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27722272
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25899627
137Phagosome_Homo sapiens_hsa041450.25311254

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