ACHE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.64485318
2muscle filament sliding (GO:0030049)8.64485318
3sarcoplasmic reticulum calcium ion transport (GO:0070296)8.32939286
4skeletal muscle contraction (GO:0003009)7.44787129
5actin-mediated cell contraction (GO:0070252)6.95265335
6regulation of skeletal muscle contraction (GO:0014819)6.61100698
7dopamine biosynthetic process (GO:0042416)6.55237776
8dopamine transport (GO:0015872)6.11379521
9neuron cell-cell adhesion (GO:0007158)5.93528708
10creatine metabolic process (GO:0006600)5.90568482
11mating behavior (GO:0007617)5.75659724
12striated muscle contraction (GO:0006941)5.71165163
13alkaloid metabolic process (GO:0009820)5.58665456
14catecholamine transport (GO:0051937)5.44589272
15phenol-containing compound catabolic process (GO:0019336)5.38234394
16actin filament-based movement (GO:0030048)5.19478214
17regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07815842
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.07458888
19regulation of relaxation of muscle (GO:1901077)5.04999711
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.04482621
21synaptic vesicle exocytosis (GO:0016079)4.99236559
22skeletal muscle fiber development (GO:0048741)4.86889539
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83009482
24vocalization behavior (GO:0071625)4.80849327
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.75631677
26myofibril assembly (GO:0030239)4.75155961
27catecholamine biosynthetic process (GO:0042423)4.62892477
28catechol-containing compound biosynthetic process (GO:0009713)4.62892477
29response to insecticide (GO:0017085)4.62563120
30sarcomere organization (GO:0045214)4.59358472
31response to inactivity (GO:0014854)4.59071400
32response to muscle activity (GO:0014850)4.58847841
33NADH metabolic process (GO:0006734)4.56220312
34neurotransmitter secretion (GO:0007269)4.51933587
35synaptic transmission, dopaminergic (GO:0001963)4.49208701
36cardiac muscle contraction (GO:0060048)4.44183256
37locomotory exploration behavior (GO:0035641)4.25404288
38glutamate secretion (GO:0014047)4.24995116
39myotube cell development (GO:0014904)4.21908605
40proline transport (GO:0015824)4.17979091
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17172645
42muscle contraction (GO:0006936)4.15230526
43synaptic vesicle maturation (GO:0016188)4.14516620
44plasma membrane repair (GO:0001778)4.08764676
45skeletal muscle adaptation (GO:0043501)4.08700970
46neurotransmitter transport (GO:0006836)4.08230698
47regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.08096665
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.01073028
49dopamine metabolic process (GO:0042417)3.97298771
50glycogen catabolic process (GO:0005980)3.93759697
51* regulation of neurotransmitter levels (GO:0001505)3.89865523
52regulation of catecholamine metabolic process (GO:0042069)3.89574269
53regulation of dopamine metabolic process (GO:0042053)3.89574269
54regulation of cell communication by electrical coupling (GO:0010649)3.89574061
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85368347
56prepulse inhibition (GO:0060134)3.84667737
57* neurotransmitter biosynthetic process (GO:0042136)3.83104117
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83023335
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79679827
60behavioral response to ethanol (GO:0048149)3.79037244
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78412427
62glucan catabolic process (GO:0009251)3.77132583
63negative regulation of neurotransmitter transport (GO:0051589)3.76122739
64regulation of synaptic vesicle exocytosis (GO:2000300)3.76090421
65regulation of protein kinase A signaling (GO:0010738)3.74867623
66response to amphetamine (GO:0001975)3.73625331
67gluconeogenesis (GO:0006094)3.73041744
68exploration behavior (GO:0035640)3.71917081
69muscle system process (GO:0003012)3.68142490
70neuron recognition (GO:0008038)3.66872084
71regulation of vesicle fusion (GO:0031338)3.63692556
72response to histamine (GO:0034776)3.61536903
73protein localization to synapse (GO:0035418)3.61156264
74muscle fiber development (GO:0048747)3.59828495
75positive regulation of synapse maturation (GO:0090129)3.54676290
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.54325559
77cardiac myofibril assembly (GO:0055003)3.53979361
78fructose metabolic process (GO:0006000)3.50027776
79behavioral response to cocaine (GO:0048148)3.49450732
80actomyosin structure organization (GO:0031032)3.48728432
81regulation of glutamate receptor signaling pathway (GO:1900449)3.48474441
82cellular polysaccharide catabolic process (GO:0044247)3.48150052
83response to cocaine (GO:0042220)3.47015815
84behavioral response to nicotine (GO:0035095)3.43643985
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.43059713
86ATP hydrolysis coupled proton transport (GO:0015991)3.43059713
87neuromuscular process controlling posture (GO:0050884)3.41814319
88* neurotransmitter catabolic process (GO:0042135)3.39451932
89regulation of actin filament-based movement (GO:1903115)3.39387165
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34039905
91hexose biosynthetic process (GO:0019319)3.33916093
92striatum development (GO:0021756)3.33149505
93* neurotransmitter metabolic process (GO:0042133)3.33091329
94neuron-neuron synaptic transmission (GO:0007270)3.32924211
952-oxoglutarate metabolic process (GO:0006103)3.32544128
96negative regulation of potassium ion transmembrane transport (GO:1901380)3.30912901
97striated muscle adaptation (GO:0014888)3.29617642
98positive regulation of synapse assembly (GO:0051965)3.29348225
99regulation of synaptic vesicle transport (GO:1902803)3.28891649
100negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.27850483
101toxin metabolic process (GO:0009404)3.27038300
102regulation of synapse structural plasticity (GO:0051823)3.26815456
103ionotropic glutamate receptor signaling pathway (GO:0035235)3.26692716
104glucan biosynthetic process (GO:0009250)3.26584968
105glycogen biosynthetic process (GO:0005978)3.26584968
106regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26492237
107regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26492237
108skeletal muscle tissue development (GO:0007519)3.24654550
109social behavior (GO:0035176)3.23023054
110intraspecies interaction between organisms (GO:0051703)3.23023054
111regulation of calcium ion transmembrane transport (GO:1903169)3.22685925
112regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22685925
113monoamine transport (GO:0015844)3.21822220
114gamma-aminobutyric acid signaling pathway (GO:0007214)3.21724526
115neuronal action potential propagation (GO:0019227)3.21484225
116multi-organism reproductive behavior (GO:0044705)3.21123719
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20891543
118energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20429695
119ATP synthesis coupled proton transport (GO:0015986)3.20429695
120regulation of glutamate secretion (GO:0014048)3.19162615
121transmission of nerve impulse (GO:0019226)3.18203648
122muscle cell cellular homeostasis (GO:0046716)3.17022314
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.16263055
124negative regulation of microtubule polymerization (GO:0031115)3.15887125
125synaptic vesicle transport (GO:0048489)3.15861684
126establishment of synaptic vesicle localization (GO:0097480)3.15861684
127regulation of dopamine secretion (GO:0014059)3.15443665
128cerebellar Purkinje cell layer development (GO:0021680)3.15178686
129oxygen transport (GO:0015671)3.13898090
130neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.13225091
131cardiac muscle hypertrophy (GO:0003300)3.12586910
132mitochondrion transport along microtubule (GO:0047497)3.12544054
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.12544054
134layer formation in cerebral cortex (GO:0021819)3.12038934
135auditory behavior (GO:0031223)3.10099158
136polysaccharide catabolic process (GO:0000272)3.09250463
137reproductive behavior (GO:0019098)3.08259739
138negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.08206579
139establishment of mitochondrion localization (GO:0051654)3.08199576
140postsynaptic membrane organization (GO:0001941)3.07104298
141synaptic vesicle docking involved in exocytosis (GO:0016081)3.06486733
142gamma-aminobutyric acid transport (GO:0015812)3.06080634
143activation of protein kinase A activity (GO:0034199)3.05208035
144axonal fasciculation (GO:0007413)3.05151445
145regulation of synaptic transmission, dopaminergic (GO:0032225)3.05087817
146neuromuscular synaptic transmission (GO:0007274)3.03578601
147regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03460156
148positive regulation of potassium ion transmembrane transport (GO:1901381)3.02934189
149electron transport chain (GO:0022900)3.02525994
150respiratory electron transport chain (GO:0022904)3.02411794
151cellular response to nicotine (GO:0071316)3.02024846
152cellular potassium ion homeostasis (GO:0030007)3.00296669
153glutamate receptor signaling pathway (GO:0007215)3.00050922
154positive regulation of neurotransmitter transport (GO:0051590)2.99216626
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.99017595
156negative regulation of calcium ion transmembrane transport (GO:1903170)2.99017595
157regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98992221
158regulation of neurotransmitter transport (GO:0051588)2.98634182
159phenol-containing compound biosynthetic process (GO:0046189)2.97488689
160striated muscle hypertrophy (GO:0014897)2.96959694
161respiratory system process (GO:0003016)2.96907647
162transferrin transport (GO:0033572)2.96237222
163regulation of neuronal synaptic plasticity (GO:0048168)2.95117282
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92715383
165positive regulation of myotube differentiation (GO:0010831)2.92703127
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92672447
167regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92488540
168regulation of sodium ion transmembrane transporter activity (GO:2000649)2.88704623
169myoblast fusion (GO:0007520)2.86344385
170monosaccharide biosynthetic process (GO:0046364)2.86274997
171striated muscle atrophy (GO:0014891)2.86008926
172regulation of striated muscle contraction (GO:0006942)2.85760128
173regulation of membrane repolarization (GO:0060306)2.84241216
174membrane depolarization during action potential (GO:0086010)2.84217510
175sodium ion export (GO:0071436)2.84015915
176porphyrin-containing compound biosynthetic process (GO:0006779)2.83213320
177regulation of synapse maturation (GO:0090128)2.83194769
178* muscle organ development (GO:0007517)2.76796868
179oxaloacetate metabolic process (GO:0006107)2.75689153
180* muscle structure development (GO:0061061)2.75015171
181regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74994078
182positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.71979857
183positive regulation of sodium ion transmembrane transport (GO:1902307)2.71476596
184glycolytic process (GO:0006096)2.71369928
185muscle adaptation (GO:0043500)2.69951623
186regulation of sodium ion transmembrane transport (GO:1902305)2.69703030
187glycogen metabolic process (GO:0005977)2.66692636
188positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65860724
189glucan metabolic process (GO:0044042)2.63545168
190cellular glucan metabolic process (GO:0006073)2.63545168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94698127
2GBX2_23144817_ChIP-Seq_PC3_Human3.33957959
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27129653
4TAF15_26573619_Chip-Seq_HEK293_Human3.17131087
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09604799
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03917884
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.03195512
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.88151110
9REST_21632747_ChIP-Seq_MESCs_Mouse2.69802284
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69699663
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67658932
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64393829
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64393829
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62652711
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61859044
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61293969
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61208481
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.55384271
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55365689
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53691122
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53632324
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.50387320
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.29889891
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29366518
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25032523
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.22694670
27LXR_22292898_ChIP-Seq_THP-1_Human2.18785050
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15808116
29ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13842320
30DROSHA_22980978_ChIP-Seq_HELA_Human2.11615387
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.11493374
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06575467
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04316883
34ZNF274_21170338_ChIP-Seq_K562_Hela2.00006325
35* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.98947515
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.94053645
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.92231257
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89041338
39AR_21572438_ChIP-Seq_LNCaP_Human1.85449457
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82862954
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.82793763
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.80697458
43* KDM2B_26808549_Chip-Seq_K562_Human1.77797542
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72827745
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.71154445
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.68925860
47SMAD4_21799915_ChIP-Seq_A2780_Human1.67643325
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67368161
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62677967
50P300_19829295_ChIP-Seq_ESCs_Human1.60241236
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57983188
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56212569
53KDM2B_26808549_Chip-Seq_DND41_Human1.54921450
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53086085
55* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52842593
56* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49527437
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49523160
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.47690558
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47338880
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45175419
61P68_20966046_ChIP-Seq_HELA_Human1.45077464
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44535771
63ZNF263_19887448_ChIP-Seq_K562_Human1.44163430
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.43785214
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43143584
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42330133
67CREB1_26743006_Chip-Seq_LNCaP_Human1.41493772
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41003942
69MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.40889075
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40778710
71SMC4_20622854_ChIP-Seq_HELA_Human1.40272969
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39551398
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.38341362
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36922057
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.34964348
76* IGF1R_20145208_ChIP-Seq_DFB_Human1.32618835
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.32523417
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.31865152
79SA1_27219007_Chip-Seq_Bcells_Human1.31782864
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29647650
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.29522147
82* GATA1_19941827_ChIP-Seq_MEL_Mouse1.29433306
83* RACK7_27058665_Chip-Seq_MCF-7_Human1.29230977
84FUS_26573619_Chip-Seq_HEK293_Human1.28402235
85AR_25329375_ChIP-Seq_VCAP_Human1.27979178
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26849432
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.26599817
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26595549
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25755520
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25311082
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25131555
92BCAT_22108803_ChIP-Seq_LS180_Human1.24838645
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24235981
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.23019444
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.23019444
96RNF2_27304074_Chip-Seq_NSC_Mouse1.22914871
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21960901
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.21800650
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21783730
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20070352
101* GATA1_19941826_ChIP-Seq_K562_Human1.19413698
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19331527
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18700510
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17755087
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15866007
106VDR_22108803_ChIP-Seq_LS180_Human1.15207903
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.14237048
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13696700
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13558377
110JUN_21703547_ChIP-Seq_K562_Human1.12903931
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12784526
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11699632
113* TCF7_22412390_ChIP-Seq_EML_Mouse1.11581191
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11409185
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09666370
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.08723363
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08663651
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08367490
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07250649
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06297263
121* OCT4_19829295_ChIP-Seq_ESCs_Human1.05516897
122STAT3_23295773_ChIP-Seq_U87_Human1.05408679
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05388170
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05386485
125CLOCK_20551151_ChIP-Seq_293T_Human1.05130143
126RUNX2_22187159_ChIP-Seq_PCA_Human1.04031654
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03072952
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.02277242
129RXR_22158963_ChIP-Seq_LIVER_Mouse1.02096665
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01094203
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00845889
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00570407
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98320446
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98217867
135* ER_23166858_ChIP-Seq_MCF-7_Human0.97875720
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.96383851
137* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96327649
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95966819
139* TCF4_23295773_ChIP-Seq_U87_Human0.95620678
140* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94453297
141AR_19668381_ChIP-Seq_PC3_Human0.94289857
142TP53_18474530_ChIP-ChIP_U2OS_Human0.92892894
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92151275
144BCL6_27268052_Chip-Seq_Bcells_Human0.91748943
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90968061
146BCOR_27268052_Chip-Seq_Bcells_Human0.90719883
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.90690346
148CTCF_21964334_Chip-Seq_Bcells_Human0.90558436
149CTCF_27219007_Chip-Seq_Bcells_Human0.89184873
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.86251592
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.85974485
152* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84947850
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84783473
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.84657426
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84498956
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84131479
157CBP_20019798_ChIP-Seq_JUKART_Human0.83724350
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83724350
159MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82921328
160KDM2B_26808549_Chip-Seq_REH_Human0.82442455
161STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81792825
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81776291
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80723961
164EWS_26573619_Chip-Seq_HEK293_Human0.80414681
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.79793338
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79051503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.13949881
2MP0003880_abnormal_central_pattern5.04083625
3MP0000749_muscle_degeneration4.82846425
4MP0002822_catalepsy4.62984464
5MP0004859_abnormal_synaptic_plasticity4.03776764
6MP0001905_abnormal_dopamine_level3.66176378
7MP0003635_abnormal_synaptic_transmissio3.50453659
8MP0004036_abnormal_muscle_relaxation3.22965811
9MP0009745_abnormal_behavioral_response3.19968905
10MP0009046_muscle_twitch3.16375149
11* MP0006276_abnormal_autonomic_nervous3.03288848
12MP0002106_abnormal_muscle_physiology3.01828961
13* MP0002064_seizures2.91970875
14MP0005451_abnormal_body_composition2.90525145
15* MP0000747_muscle_weakness2.88200150
16MP0005423_abnormal_somatic_nervous2.86739431
17MP0000759_abnormal_skeletal_muscle2.85109920
18MP0001440_abnormal_grooming_behavior2.84758433
19MP0004087_abnormal_muscle_fiber2.76521585
20MP0003122_maternal_imprinting2.72256279
21MP0001501_abnormal_sleep_pattern2.69069747
22MP0002572_abnormal_emotion/affect_behav2.62834063
23MP0001968_abnormal_touch/_nociception2.62763173
24MP0002063_abnormal_learning/memory/cond2.62599122
25MP0004130_abnormal_muscle_cell2.56016505
26MP0004147_increased_porphyrin_level2.51104760
27MP0005369_muscle_phenotype2.49219121
28MP0002733_abnormal_thermal_nociception2.48623778
29MP0000750_abnormal_muscle_regeneration2.46723582
30MP0002734_abnormal_mechanical_nocicepti2.45612153
31MP0004270_analgesia2.45536594
32MP0002269_muscular_atrophy2.36504812
33MP0002272_abnormal_nervous_system2.34159112
34* MP0001529_abnormal_vocalization2.31755786
35MP0004233_abnormal_muscle_weight2.30858075
36MP0005620_abnormal_muscle_contractility2.27082072
37MP0002735_abnormal_chemical_nociception2.25627140
38MP0001970_abnormal_pain_threshold2.19678557
39MP0005645_abnormal_hypothalamus_physiol2.18661089
40MP0001486_abnormal_startle_reflex2.17066579
41* MP0002332_abnormal_exercise_endurance2.04517692
42MP0004084_abnormal_cardiac_muscle2.03954990
43MP0005330_cardiomyopathy2.02700342
44MP0002736_abnormal_nociception_after2.00998390
45* MP0004924_abnormal_behavior1.92579433
46* MP0005386_behavior/neurological_phenoty1.92579433
47MP0002909_abnormal_adrenal_gland1.88842435
48MP0003656_abnormal_erythrocyte_physiolo1.85057673
49* MP0002067_abnormal_sensory_capabilities1.85021379
50MP0002184_abnormal_innervation1.84319683
51MP0004142_abnormal_muscle_tone1.78666876
52MP0001188_hyperpigmentation1.74137177
53MP0002557_abnormal_social/conspecific_i1.72151411
54MP0002972_abnormal_cardiac_muscle1.65017336
55MP0006036_abnormal_mitochondrial_physio1.61619333
56MP0000733_abnormal_muscle_development1.58133392
57MP0010386_abnormal_urinary_bladder1.51800781
58MP0004510_myositis1.51567278
59MP0005646_abnormal_pituitary_gland1.49941704
60MP0003329_amyloid_beta_deposits1.49468412
61MP0004858_abnormal_nervous_system1.48164875
62MP0008569_lethality_at_weaning1.47844376
63MP0000778_abnormal_nervous_system1.44015511
64MP0002638_abnormal_pupillary_reflex1.43387319
65* MP0008872_abnormal_physiological_respon1.41090536
66MP0000751_myopathy1.38840178
67MP0002837_dystrophic_cardiac_calcinosis1.38586152
68* MP0002066_abnormal_motor_capabilities/c1.34457692
69MP0000538_abnormal_urinary_bladder1.32246384
70MP0004811_abnormal_neuron_physiology1.30944120
71MP0001984_abnormal_olfaction1.30905309
72MP0001502_abnormal_circadian_rhythm1.30217981
73MP0002876_abnormal_thyroid_physiology1.29867733
74MP0000955_abnormal_spinal_cord1.28550029
75MP0002971_abnormal_brown_adipose1.28252108
76MP0009840_abnormal_foam_cell1.26356853
77MP0002108_abnormal_muscle_morphology1.23810176
78MP0004484_altered_response_of1.22629262
79MP0002882_abnormal_neuron_morphology1.21915012
80MP0005409_darkened_coat_color1.20013364
81* MP0005535_abnormal_body_temperature1.19369862
82MP0003221_abnormal_cardiomyocyte_apopto1.15244483
83MP0005083_abnormal_biliary_tract1.14394231
84MP0003879_abnormal_hair_cell1.12446276
85MP0010630_abnormal_cardiac_muscle1.12195677
86MP0002254_reproductive_system_inflammat1.10492307
87MP0006138_congestive_heart_failure1.10013879
88MP0002751_abnormal_autonomic_nervous1.09926946
89MP0001664_abnormal_digestion1.09506535
90MP0002090_abnormal_vision1.04875093
91MP0006072_abnormal_retinal_apoptosis1.00977759
92MP0003137_abnormal_impulse_conducting0.99510884
93MP0002069_abnormal_eating/drinking_beha0.99255762
94MP0004742_abnormal_vestibular_system0.97453733
95MP0003633_abnormal_nervous_system0.96431731
96MP0005385_cardiovascular_system_phenoty0.95852389
97MP0001544_abnormal_cardiovascular_syste0.95852389
98MP0003631_nervous_system_phenotype0.95227595
99MP0002229_neurodegeneration0.94475937
100MP0008874_decreased_physiological_sensi0.94470619
101* MP0005266_abnormal_metabolism0.94189797
102MP0005666_abnormal_adipose_tissue0.93657940
103MP0005551_abnormal_eye_electrophysiolog0.90789937
104MP0005375_adipose_tissue_phenotype0.90192536
105MP0005670_abnormal_white_adipose0.89391862
106MP0002127_abnormal_cardiovascular_syste0.87512240
107MP0000631_abnormal_neuroendocrine_gland0.87322153
108MP0001348_abnormal_lacrimal_gland0.87272090
109MP0000013_abnormal_adipose_tissue0.85590433
110MP0000003_abnormal_adipose_tissue0.85384136
111MP0004145_abnormal_muscle_electrophysio0.84942269
112* MP0002152_abnormal_brain_morphology0.84737621
113MP0005379_endocrine/exocrine_gland_phen0.82868734
114MP0000639_abnormal_adrenal_gland0.81453355
115MP0004085_abnormal_heartbeat0.78158221
116MP0005394_taste/olfaction_phenotype0.78129981
117MP0005499_abnormal_olfactory_system0.78129981
118MP0005167_abnormal_blood-brain_barrier0.77679022
119MP0003632_abnormal_nervous_system0.77263134
120MP0008775_abnormal_heart_ventricle0.76903888
121MP0002752_abnormal_somatic_nervous0.75933941
122MP0002163_abnormal_gland_morphology0.75562233
123MP0009780_abnormal_chondrocyte_physiolo0.74465947
124MP0009379_abnormal_foot_pigmentation0.73084923
125MP0003121_genomic_imprinting0.70115884
126MP0003787_abnormal_imprinting0.69044467
127MP0003634_abnormal_glial_cell0.64328411
128MP0006035_abnormal_mitochondrial_morpho0.64213724
129MP0001177_atelectasis0.63779553
130MP0004185_abnormal_adipocyte_glucose0.63279770
131MP0002078_abnormal_glucose_homeostasis0.63050645
132MP0005584_abnormal_enzyme/coenzyme_acti0.62935697
133MP0003183_abnormal_peptide_metabolism0.62827879
134MP0001963_abnormal_hearing_physiology0.62463282
135MP0004215_abnormal_myocardial_fiber0.62151635
136MP0000604_amyloidosis0.61860095
137* MP0001943_abnormal_respiration0.60985692
138MP0008260_abnormal_autophagy0.60183555
139MP0003123_paternal_imprinting0.58583314
140MP0001299_abnormal_eye_distance/0.58009081
141MP0005310_abnormal_salivary_gland0.56176445
142MP0008961_abnormal_basal_metabolism0.55885486
143MP0003283_abnormal_digestive_organ0.54341439
144MP0003045_fibrosis0.54238710
145MP0003690_abnormal_glial_cell0.53814363
146MP0003948_abnormal_gas_homeostasis0.53450881
147MP0004885_abnormal_endolymph0.50949627
148MP0001346_abnormal_lacrimal_gland0.49135583

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.35258818
2Muscle fiber inclusion bodies (HP:0100299)9.33850895
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.05007137
4Limb dystonia (HP:0002451)8.22571737
5Exercise-induced myalgia (HP:0003738)7.47261806
6Type 1 muscle fiber predominance (HP:0003803)7.04078840
7Exercise-induced muscle cramps (HP:0003710)6.61103893
8Focal motor seizures (HP:0011153)5.95702334
9Myopathic facies (HP:0002058)5.77331445
10Muscle hypertrophy of the lower extremities (HP:0008968)5.54131432
11Distal arthrogryposis (HP:0005684)5.45854042
12Myokymia (HP:0002411)5.34594578
13Visual hallucinations (HP:0002367)5.32915709
14Hypothermia (HP:0002045)5.24789595
15Calf muscle hypertrophy (HP:0008981)4.96717856
16Focal seizures (HP:0007359)4.89656647
17Pheochromocytoma (HP:0002666)4.88489540
18EMG: myopathic abnormalities (HP:0003458)4.62500839
19Round ear (HP:0100830)4.59576369
20Myoglobinuria (HP:0002913)4.49629177
21Neuroendocrine neoplasm (HP:0100634)4.40726874
22Rhabdomyolysis (HP:0003201)4.40661333
23Muscle fiber splitting (HP:0003555)4.31517426
24Ulnar deviation of the wrist (HP:0003049)4.29794887
25Failure to thrive in infancy (HP:0001531)4.29431049
26Centrally nucleated skeletal muscle fibers (HP:0003687)4.21339098
27Hyporeflexia of lower limbs (HP:0002600)4.08255638
28Atonic seizures (HP:0010819)3.98340724
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.94413022
30Abnormality of the calf musculature (HP:0001430)3.90418856
31Progressive cerebellar ataxia (HP:0002073)3.86575464
32Absence seizures (HP:0002121)3.85512676
33Generalized tonic-clonic seizures (HP:0002069)3.83350018
34Abnormality of skeletal muscle fiber size (HP:0012084)3.82491805
35Difficulty running (HP:0009046)3.81627091
36Calcaneovalgus deformity (HP:0001848)3.74923454
37Neck muscle weakness (HP:0000467)3.73384729
38Febrile seizures (HP:0002373)3.55881094
39Hypoventilation (HP:0002791)3.54283852
40Muscle stiffness (HP:0003552)3.53107996
41Increased connective tissue (HP:0009025)3.45429679
42Dialeptic seizures (HP:0011146)3.43230994
43Abnormality of the left ventricular outflow tract (HP:0011103)3.38904596
44Subaortic stenosis (HP:0001682)3.38904596
45Hypercortisolism (HP:0001578)3.38384109
46Distal lower limb muscle weakness (HP:0009053)3.32126266
47Deformed tarsal bones (HP:0008119)3.30046171
48Acute necrotizing encephalopathy (HP:0006965)3.29476407
49Frequent falls (HP:0002359)3.28554930
50Increased variability in muscle fiber diameter (HP:0003557)3.27264341
51Abnormality of calcium-phosphate metabolism (HP:0100530)3.20259155
52Absent phalangeal crease (HP:0006109)3.14899577
53Supranuclear gaze palsy (HP:0000605)3.14382356
54Abnormal pupillary function (HP:0007686)3.14156990
55Anxiety (HP:0000739)3.14005395
56Cerebral hemorrhage (HP:0001342)3.11821580
57EMG: neuropathic changes (HP:0003445)3.11053271
58Epileptic encephalopathy (HP:0200134)3.10920387
59Progressive inability to walk (HP:0002505)3.10219409
60Sudden death (HP:0001699)3.10024120
61Distal lower limb amyotrophy (HP:0008944)3.04714810
62Potter facies (HP:0002009)2.98288309
63Facial shape deformation (HP:0011334)2.98288309
64Cerebral inclusion bodies (HP:0100314)2.97671243
65Malignant hyperthermia (HP:0002047)2.97577893
66Abnormal mitochondria in muscle tissue (HP:0008316)2.97152616
67Asymmetric septal hypertrophy (HP:0001670)2.96722426
68Mitochondrial inheritance (HP:0001427)2.95224094
69Progressive macrocephaly (HP:0004481)2.93431969
70Polyphagia (HP:0002591)2.90887744
71Hypokinesia (HP:0002375)2.82139806
72Lower limb amyotrophy (HP:0007210)2.74827526
73Depression (HP:0000716)2.73131380
74Amblyopia (HP:0000646)2.69872412
75Agitation (HP:0000713)2.69217723
76Neurofibrillary tangles (HP:0002185)2.67283276
77Abnormal eating behavior (HP:0100738)2.63636713
78Bundle branch block (HP:0011710)2.63002201
79Mildly elevated creatine phosphokinase (HP:0008180)2.61665424
80Areflexia of lower limbs (HP:0002522)2.50940682
81Abnormal finger flexion creases (HP:0006143)2.50103971
82Generalized muscle weakness (HP:0003324)2.49957463
83Abnormality of the foot musculature (HP:0001436)2.47652934
84Bulbar palsy (HP:0001283)2.46716326
85Action tremor (HP:0002345)2.44113276
86Difficulty climbing stairs (HP:0003551)2.44093993
87Foot dorsiflexor weakness (HP:0009027)2.43919963
88Neoplasm of the peripheral nervous system (HP:0100007)2.40851869
89Acute encephalopathy (HP:0006846)2.40625898
90Psychosis (HP:0000709)2.39354630
91Abnormal hair whorl (HP:0010721)2.38116121
92Truncal ataxia (HP:0002078)2.38041789
93Diminished movement (HP:0002374)2.37567829
94Ankle clonus (HP:0011448)2.36198785
95Genital tract atresia (HP:0001827)2.35361334
96Rigidity (HP:0002063)2.35198571
97Bradykinesia (HP:0002067)2.34048034
98Mutism (HP:0002300)2.31396837
99Broad-based gait (HP:0002136)2.31057208
100Increased CSF lactate (HP:0002490)2.27439242
101Vaginal atresia (HP:0000148)2.25159619
102Poor suck (HP:0002033)2.25118224
103Abnormality of the calcaneus (HP:0008364)2.24664080
104Limb-girdle muscle atrophy (HP:0003797)2.23157155
105Postural tremor (HP:0002174)2.18660659
106Gowers sign (HP:0003391)2.18627662
107Delayed gross motor development (HP:0002194)2.17682931
108Hepatocellular necrosis (HP:0001404)2.16742065
109Weak cry (HP:0001612)2.16475145
110Delusions (HP:0000746)2.15105123
111Akinesia (HP:0002304)2.14762576
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13185147
113Morphological abnormality of the pyramidal tract (HP:0002062)2.12882597
114Dysmetria (HP:0001310)2.11432487
115Cholelithiasis (HP:0001081)2.09988067
116Impaired vibration sensation in the lower limbs (HP:0002166)2.09565748
117Orthostatic hypotension (HP:0001278)2.08348363
118Hemiparesis (HP:0001269)2.07703142
119Termporal pattern (HP:0011008)2.06992269
120Insidious onset (HP:0003587)2.06992269
121Papilledema (HP:0001085)2.06491354
122Abnormality of the corticospinal tract (HP:0002492)2.05497787
123Scapular winging (HP:0003691)2.04981617
124Exotropia (HP:0000577)2.04429111
125Slender build (HP:0001533)2.03647608
126Myotonia (HP:0002486)2.03187817
127Reticulocytosis (HP:0001923)2.02518955
128Paralysis (HP:0003470)2.00501570
129Abnormality of the neuromuscular junction (HP:0003398)2.00042809
130Fatigable weakness (HP:0003473)2.00042809
131Abnormality of binocular vision (HP:0011514)1.99832198
132Diplopia (HP:0000651)1.99832198
133Abnormality of the parathyroid morphology (HP:0011766)1.98514869
134Hyperthyroidism (HP:0000836)1.98442715
135Dilated cardiomyopathy (HP:0001644)1.98259101
136Esotropia (HP:0000565)1.97120223
137Muscular hypotonia of the trunk (HP:0008936)1.95581093
138Torticollis (HP:0000473)1.94425667
139Gait imbalance (HP:0002141)1.94341312
140Optic disc pallor (HP:0000543)1.93914141
141Fetal akinesia sequence (HP:0001989)1.93552336
142Hyperkalemia (HP:0002153)1.93146731
143Abnormal ciliary motility (HP:0012262)1.91858899
144Poor eye contact (HP:0000817)1.91598490
145Spinal rigidity (HP:0003306)1.91467745
146Emotional lability (HP:0000712)1.90560005
147Heart block (HP:0012722)1.90490309
148Dysdiadochokinesis (HP:0002075)1.89886380
149Ventricular tachycardia (HP:0004756)1.89303768
150Spastic gait (HP:0002064)1.89242388
151Rapidly progressive (HP:0003678)1.88907468
152Abnormal autonomic nervous system physiology (HP:0012332)1.88246699
153Hyperparathyroidism (HP:0000843)1.88012877
154Waddling gait (HP:0002515)1.86646657
155Narrow nasal bridge (HP:0000446)1.86600466
156Oligomenorrhea (HP:0000876)1.86106219
157Abnormal gallbladder morphology (HP:0012437)1.85991421
158Increased hepatocellular lipid droplets (HP:0006565)1.85328176
159Impaired social interactions (HP:0000735)1.85191512
160Abnormal social behavior (HP:0012433)1.85191512
161Abnormal gallbladder physiology (HP:0012438)1.84819736
162Cholecystitis (HP:0001082)1.84819736
163Rimmed vacuoles (HP:0003805)1.84464589
164Urinary urgency (HP:0000012)1.84060844
165Focal dystonia (HP:0004373)1.83418219
166EEG with generalized epileptiform discharges (HP:0011198)1.82712227
167Abnormal atrioventricular conduction (HP:0005150)1.81881519
168Hip contracture (HP:0003273)1.79438104
169Shoulder girdle muscle weakness (HP:0003547)1.78263928
170Proximal amyotrophy (HP:0007126)1.76077925
171Muscular dystrophy (HP:0003560)1.74723403
172Progressive muscle weakness (HP:0003323)1.71829012
173Diaphragmatic weakness (HP:0009113)1.71588246
174Abnormality of the musculature of the pelvis (HP:0001469)1.71458381
175Abnormality of the hip-girdle musculature (HP:0001445)1.71458381
176Metatarsus adductus (HP:0001840)1.70471137
177Abnormality of the shoulder girdle musculature (HP:0001435)1.65852078
178Steppage gait (HP:0003376)1.65246990
179Respiratory insufficiency due to muscle weakness (HP:0002747)1.64069786
180Pelvic girdle muscle weakness (HP:0003749)1.63961261
181Achilles tendon contracture (HP:0001771)1.63492703
182Lipoatrophy (HP:0100578)1.62846796
183Poikilocytosis (HP:0004447)1.62763652
184Limb-girdle muscle weakness (HP:0003325)1.62402143
185Cerebral palsy (HP:0100021)1.62358433
186Abnormality of the heme biosynthetic pathway (HP:0010472)1.58879232
187Popliteal pterygium (HP:0009756)1.58861690
188Long clavicles (HP:0000890)1.57692460
189Nonprogressive disorder (HP:0003680)1.56919078
190Stridor (HP:0010307)1.56425549
191Ragged-red muscle fibers (HP:0003200)1.55314532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.74291604
2TTN4.50612934
3MAP3K123.94388784
4MAPKAPK53.60951320
5PNCK3.51118295
6MAP3K93.43537810
7NTRK33.35460006
8MAP3K43.02583581
9NTRK13.01538340
10ARAF2.84761412
11GRK52.55343687
12MINK12.46425268
13MAP2K42.45564415
14MAP2K72.32855096
15MARK12.29647133
16GRK72.16032473
17NTRK22.06129781
18MAPK122.01625776
19EPHA41.93329917
20CSNK1G21.89974481
21CSNK1G31.88032238
22PINK11.75977374
23CASK1.72296093
24KSR21.58003432
25MAP2K31.57565182
26MAP3K131.54627543
27NME11.54479836
28RIPK11.50831622
29PIK3CG1.43090698
30PLK21.34975386
31CDK51.34635862
32ADRBK21.31504753
33CAMK2A1.29066313
34MAP3K71.25025362
35CSNK1G11.24438957
36PRPF4B1.23869846
37CAMK2B1.22886216
38UHMK11.22159996
39RET1.22032172
40DYRK1B1.20574741
41TRIB31.20107706
42SIK11.18894898
43MAPK131.17604490
44MAP3K111.16077334
45CDK151.14815130
46PAK61.13649162
47CDK181.13450990
48PHKG11.10589015
49PHKG21.10589015
50LATS21.10232961
51CDK141.10134304
52TSSK61.09912274
53CAMK2D1.09751093
54SIK21.07512972
55PRKCG1.06626283
56MUSK1.05868103
57MAP2K61.03076624
58CDK11A1.01720502
59CAMK2G1.00055721
60TNIK0.99119043
61MAPKAPK30.98847879
62FES0.98660132
63ADRBK10.97813479
64EEF2K0.95897334
65DAPK20.94212027
66TAOK10.92104338
67MARK20.92069250
68RIPK40.91398185
69PRKAA10.91045326
70TAOK20.89459047
71GRK60.87268072
72SCYL20.86494875
73STK390.84467006
74CAMK1G0.84015655
75ICK0.81914372
76CAMKK20.78899671
77KSR10.78108412
78WNK40.77791662
79CDK190.77695214
80PAK30.77216877
81TNK20.75852106
82EPHB10.75520263
83EPHA30.71683439
84LMTK20.71055071
85OXSR10.70686261
86FGR0.70500826
87PKN10.69576357
88CAMK40.68800088
89CAMKK10.67562818
90TESK10.64876888
91CCNB10.63652508
92AKT20.63633784
93PTK2B0.63444607
94RAF10.61467478
95MAPK40.61390180
96MAP2K10.60972701
97PRKCE0.59737215
98MAP3K10.59712303
99STK110.59384784
100MOS0.59175180
101BRAF0.57602694
102PTK20.57300293
103PRKAA20.56967019
104FER0.56224498
105SGK30.55302000
106CAMK10.54687710
107BCKDK0.52878837
108DAPK10.52820594
109MAP3K20.52301206
110PDPK10.51950443
111DMPK0.50682696
112SGK4940.50183331
113SGK2230.50183331
114WNK10.49319430
115ROCK20.49119354
116DYRK1A0.47715062
117PRKACA0.47129887
118DYRK20.46105575
119MATK0.43987707
120RPS6KA20.42444029
121CSNK1E0.40885002
122TYRO30.40637780
123PRKCH0.40010945
124TBK10.39428015
125PRKG10.38172595
126MAP3K60.37896560
127LIMK10.37872144
128SGK10.37409197
129RPS6KA30.37103982
130MAPK70.36755708
131BMPR1B0.36039807
132PRKCB0.35599186
133MYLK0.35437291
134PRKD30.35424879
135SGK20.35278978
136FYN0.34231811
137PIK3CA0.33703946
138ROCK10.33359361
139PDK10.32199189
140TRPM70.32179231
141CDC42BPA0.31344712
142DAPK30.31226947
143BMPR20.31129240
144MAPK110.30901941
145MAPK100.30769419
146PRKCA0.30392944
147ERBB30.30160885
148PRKG20.29662831
149PRKACG0.29338447
150MTOR0.28141829

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.85573543
2Nicotine addiction_Homo sapiens_hsa050333.73133717
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.39915757
4Oxidative phosphorylation_Homo sapiens_hsa001903.38166327
5Parkinsons disease_Homo sapiens_hsa050123.14851109
6Cocaine addiction_Homo sapiens_hsa050303.06038697
7Amphetamine addiction_Homo sapiens_hsa050312.83583534
8Collecting duct acid secretion_Homo sapiens_hsa049662.72060354
9GABAergic synapse_Homo sapiens_hsa047272.49736369
10Dopaminergic synapse_Homo sapiens_hsa047282.40722128
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38707983
12Alzheimers disease_Homo sapiens_hsa050102.29111591
13Arginine biosynthesis_Homo sapiens_hsa002202.27163330
14Serotonergic synapse_Homo sapiens_hsa047262.19910193
15Olfactory transduction_Homo sapiens_hsa047402.10301875
16Circadian entrainment_Homo sapiens_hsa047132.04247747
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02521643
18Morphine addiction_Homo sapiens_hsa050322.02135581
19Fructose and mannose metabolism_Homo sapiens_hsa000511.98932019
20Long-term potentiation_Homo sapiens_hsa047201.93846727
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92569397
22Cardiac muscle contraction_Homo sapiens_hsa042601.90404246
23Arginine and proline metabolism_Homo sapiens_hsa003301.86701772
24Glutamatergic synapse_Homo sapiens_hsa047241.85276049
25Vibrio cholerae infection_Homo sapiens_hsa051101.80835505
26Huntingtons disease_Homo sapiens_hsa050161.79600967
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77257785
28Taste transduction_Homo sapiens_hsa047421.76845727
29Salivary secretion_Homo sapiens_hsa049701.73455565
30Long-term depression_Homo sapiens_hsa047301.71850579
31Carbon metabolism_Homo sapiens_hsa012001.67925200
32* Cholinergic synapse_Homo sapiens_hsa047251.66358048
33Renin secretion_Homo sapiens_hsa049241.60519789
34Insulin secretion_Homo sapiens_hsa049111.57952007
35Gastric acid secretion_Homo sapiens_hsa049711.48799860
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47882529
37Tyrosine metabolism_Homo sapiens_hsa003501.47326251
38AMPK signaling pathway_Homo sapiens_hsa041521.44467151
39Calcium signaling pathway_Homo sapiens_hsa040201.42600324
40Circadian rhythm_Homo sapiens_hsa047101.39500969
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35475717
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33634285
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30987151
44Pentose phosphate pathway_Homo sapiens_hsa000301.27161293
45Phenylalanine metabolism_Homo sapiens_hsa003601.26764954
46Biosynthesis of amino acids_Homo sapiens_hsa012301.26512358
47Gap junction_Homo sapiens_hsa045401.26230462
48GnRH signaling pathway_Homo sapiens_hsa049121.22956563
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22778072
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22338821
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17227558
52Oxytocin signaling pathway_Homo sapiens_hsa049211.16955095
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.08962633
54Insulin resistance_Homo sapiens_hsa049311.02264896
55Starch and sucrose metabolism_Homo sapiens_hsa005001.01231164
56Galactose metabolism_Homo sapiens_hsa000520.99218689
57Fatty acid metabolism_Homo sapiens_hsa012120.95644162
58Estrogen signaling pathway_Homo sapiens_hsa049150.95273775
59Alcoholism_Homo sapiens_hsa050340.93438305
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89477764
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.84716501
62Rheumatoid arthritis_Homo sapiens_hsa053230.84300140
63PPAR signaling pathway_Homo sapiens_hsa033200.83902299
64Phototransduction_Homo sapiens_hsa047440.77677731
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77302282
66Fatty acid degradation_Homo sapiens_hsa000710.75976802
67Melanogenesis_Homo sapiens_hsa049160.75773405
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.75744037
69cAMP signaling pathway_Homo sapiens_hsa040240.74029020
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72412348
71Thyroid hormone synthesis_Homo sapiens_hsa049180.71910690
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71365488
73Tight junction_Homo sapiens_hsa045300.71355720
74Pancreatic secretion_Homo sapiens_hsa049720.70328236
75Dorso-ventral axis formation_Homo sapiens_hsa043200.69199161
76African trypanosomiasis_Homo sapiens_hsa051430.69062331
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68983442
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68261140
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66300130
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65127693
81Axon guidance_Homo sapiens_hsa043600.62195883
82Sulfur relay system_Homo sapiens_hsa041220.61470088
83VEGF signaling pathway_Homo sapiens_hsa043700.60221071
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59504817
85Type II diabetes mellitus_Homo sapiens_hsa049300.55890908
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54916910
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54102843
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52583285
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52343787
90Dilated cardiomyopathy_Homo sapiens_hsa054140.52183355
91Oocyte meiosis_Homo sapiens_hsa041140.51822779
92Histidine metabolism_Homo sapiens_hsa003400.51597009
93Phagosome_Homo sapiens_hsa041450.51172931
94Type I diabetes mellitus_Homo sapiens_hsa049400.50893026
95Nitrogen metabolism_Homo sapiens_hsa009100.50849932
96Regulation of autophagy_Homo sapiens_hsa041400.49623333
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48963865
98ErbB signaling pathway_Homo sapiens_hsa040120.47553545
99Prion diseases_Homo sapiens_hsa050200.47325025
100Glucagon signaling pathway_Homo sapiens_hsa049220.46216452
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44549213
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44381673
103Fat digestion and absorption_Homo sapiens_hsa049750.43262817
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.41898540
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40711216
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39621318
107Fatty acid elongation_Homo sapiens_hsa000620.39434633
108MAPK signaling pathway_Homo sapiens_hsa040100.39205176
109Bile secretion_Homo sapiens_hsa049760.37913992
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37000803
111Glioma_Homo sapiens_hsa052140.36792791
112Butanoate metabolism_Homo sapiens_hsa006500.35481890
113Pyruvate metabolism_Homo sapiens_hsa006200.35274527
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34927865
115Propanoate metabolism_Homo sapiens_hsa006400.31687830
116Ovarian steroidogenesis_Homo sapiens_hsa049130.26650649
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26343785
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.24365038
119Choline metabolism in cancer_Homo sapiens_hsa052310.23939475
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23857497
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22489894
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21476288
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20446558
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20178882
125Inositol phosphate metabolism_Homo sapiens_hsa005620.20159974
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19555988
127* Glycerophospholipid metabolism_Homo sapiens_hsa005640.19243413
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.19145714
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17744508
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16908195
131Prolactin signaling pathway_Homo sapiens_hsa049170.15473247
132Ras signaling pathway_Homo sapiens_hsa040140.15293816
133Insulin signaling pathway_Homo sapiens_hsa049100.13641231
134Wnt signaling pathway_Homo sapiens_hsa043100.12616282
135Ether lipid metabolism_Homo sapiens_hsa005650.11397524

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