ACBD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16433109
2L-phenylalanine catabolic process (GO:0006559)7.16433109
3L-phenylalanine metabolic process (GO:0006558)6.69928778
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69928778
5aromatic amino acid family catabolic process (GO:0009074)6.32535152
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.61833401
7bile acid biosynthetic process (GO:0006699)5.61134942
8indole-containing compound catabolic process (GO:0042436)5.54923900
9indolalkylamine catabolic process (GO:0046218)5.54923900
10tryptophan catabolic process (GO:0006569)5.54923900
11kynurenine metabolic process (GO:0070189)5.35968900
12alpha-linolenic acid metabolic process (GO:0036109)5.31030129
13tryptophan metabolic process (GO:0006568)5.27858700
14glyoxylate metabolic process (GO:0046487)5.15834829
15urea metabolic process (GO:0019627)5.10295251
16urea cycle (GO:0000050)5.10295251
17cysteine metabolic process (GO:0006534)5.10114683
18high-density lipoprotein particle remodeling (GO:0034375)4.96268166
19protein carboxylation (GO:0018214)4.90381191
20peptidyl-glutamic acid carboxylation (GO:0017187)4.90381191
21complement activation, alternative pathway (GO:0006957)4.89781945
22sulfur amino acid catabolic process (GO:0000098)4.86631967
23negative regulation of fibrinolysis (GO:0051918)4.83220617
24bile acid metabolic process (GO:0008206)4.81159200
25regulation of protein activation cascade (GO:2000257)4.77188740
26regulation of fibrinolysis (GO:0051917)4.70539779
27nitrogen cycle metabolic process (GO:0071941)4.67855488
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59045858
29aromatic amino acid family metabolic process (GO:0009072)4.55100471
30tyrosine metabolic process (GO:0006570)4.49137097
31regulation of complement activation (GO:0030449)4.49031565
32cellular ketone body metabolic process (GO:0046950)4.48589937
33serine family amino acid catabolic process (GO:0009071)4.40910997
34homocysteine metabolic process (GO:0050667)4.40771746
35reverse cholesterol transport (GO:0043691)4.38617407
36regulation of triglyceride catabolic process (GO:0010896)4.36399439
37lysine catabolic process (GO:0006554)4.31532761
38lysine metabolic process (GO:0006553)4.31532761
39plasma lipoprotein particle remodeling (GO:0034369)4.26144635
40protein-lipid complex remodeling (GO:0034368)4.26144635
41macromolecular complex remodeling (GO:0034367)4.26144635
42alpha-amino acid catabolic process (GO:1901606)4.25170311
43regulation of cholesterol esterification (GO:0010872)4.22447433
44triglyceride homeostasis (GO:0070328)4.19795357
45acylglycerol homeostasis (GO:0055090)4.19795357
46coenzyme catabolic process (GO:0009109)4.17390473
47epoxygenase P450 pathway (GO:0019373)4.15873662
48glutamate metabolic process (GO:0006536)4.11586713
49bile acid and bile salt transport (GO:0015721)4.09928365
50amino-acid betaine metabolic process (GO:0006577)4.09340029
51phospholipid efflux (GO:0033700)4.02397112
52indolalkylamine metabolic process (GO:0006586)4.01063838
53cellular glucuronidation (GO:0052695)4.00326436
54plasma lipoprotein particle clearance (GO:0034381)3.97608466
55cellular amino acid catabolic process (GO:0009063)3.96934907
56cholesterol efflux (GO:0033344)3.95860220
57negative regulation of sterol transport (GO:0032372)3.91672091
58negative regulation of cholesterol transport (GO:0032375)3.91672091
59ketone body metabolic process (GO:1902224)3.87467810
60amine catabolic process (GO:0009310)3.82694857
61cellular biogenic amine catabolic process (GO:0042402)3.82694857
62drug catabolic process (GO:0042737)3.80664683
63ethanol oxidation (GO:0006069)3.77464690
64dicarboxylic acid biosynthetic process (GO:0043650)3.77132485
65cellular modified amino acid catabolic process (GO:0042219)3.72640816
66benzene-containing compound metabolic process (GO:0042537)3.72598266
67short-chain fatty acid metabolic process (GO:0046459)3.70650757
68acetyl-CoA metabolic process (GO:0006084)3.69488025
69astrocyte differentiation (GO:0048708)3.66797085
70glucuronate metabolic process (GO:0019585)3.59739156
71uronic acid metabolic process (GO:0006063)3.59739156
72regulation of bile acid biosynthetic process (GO:0070857)3.59503968
73low-density lipoprotein particle remodeling (GO:0034374)3.58458934
74imidazole-containing compound metabolic process (GO:0052803)3.57890203
75serine family amino acid metabolic process (GO:0009069)3.56843563
76fibrinolysis (GO:0042730)3.54386116
77arginine metabolic process (GO:0006525)3.53031575
78positive regulation of lipid catabolic process (GO:0050996)3.52570965
79carboxylic acid catabolic process (GO:0046395)3.50066341
80organic acid catabolic process (GO:0016054)3.50066341
81regulation of cholesterol homeostasis (GO:2000188)3.47714965
82phospholipid homeostasis (GO:0055091)3.46068551
83cofactor catabolic process (GO:0051187)3.45720491
84plasma lipoprotein particle assembly (GO:0034377)3.45119108
85drug transmembrane transport (GO:0006855)3.44573547
86aldehyde catabolic process (GO:0046185)3.43360333
87nucleobase catabolic process (GO:0046113)3.41312024
88negative regulation of lipase activity (GO:0060192)3.40248526
89glycine metabolic process (GO:0006544)3.38874586
90cholesterol homeostasis (GO:0042632)3.38613267
91omega-hydroxylase P450 pathway (GO:0097267)3.37723219
92complement activation, classical pathway (GO:0006958)3.37042534
93very-low-density lipoprotein particle assembly (GO:0034379)3.36711405
94cytolysis (GO:0019835)3.35463991
95complement activation (GO:0006956)3.35072415
96sterol homeostasis (GO:0055092)3.35060776
97very long-chain fatty acid metabolic process (GO:0000038)3.34775833
98exogenous drug catabolic process (GO:0042738)3.34681312
99aspartate family amino acid catabolic process (GO:0009068)3.33906146
100monocarboxylic acid catabolic process (GO:0072329)3.31813517
101pyrimidine nucleobase catabolic process (GO:0006208)3.30905302
102positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29422543
103fatty acid oxidation (GO:0019395)3.28698599
104positive regulation of lipoprotein lipase activity (GO:0051006)3.27907247
105positive regulation of triglyceride lipase activity (GO:0061365)3.27907247
106positive regulation of fatty acid beta-oxidation (GO:0032000)3.27738465
107regulation of cell communication by electrical coupling (GO:0010649)3.17166624
108detection of calcium ion (GO:0005513)3.01787462
109daunorubicin metabolic process (GO:0044597)2.96159516
110polyketide metabolic process (GO:0030638)2.96159516
111doxorubicin metabolic process (GO:0044598)2.96159516
112C4-dicarboxylate transport (GO:0015740)2.94701528
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89134025
114carnitine metabolic process (GO:0009437)2.84707842
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.82977609
116cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81885936
117positive regulation of glycolytic process (GO:0045821)2.81594698
118cellular potassium ion homeostasis (GO:0030007)2.80913562
119ionotropic glutamate receptor signaling pathway (GO:0035235)2.74789613
120fat-soluble vitamin biosynthetic process (GO:0042362)2.74173645
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.73880489
122regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71709414
123regulation of protein glycosylation (GO:0060049)2.67628706
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.67602191
125* macroautophagy (GO:0016236)2.67120003
126aminoglycoside antibiotic metabolic process (GO:0030647)2.66989923
127presynaptic membrane assembly (GO:0097105)2.66559253
128embryonic retina morphogenesis in camera-type eye (GO:0060059)2.64178208
129fructose metabolic process (GO:0006000)2.63648405
130drug metabolic process (GO:0017144)2.60002889
131sodium ion export (GO:0071436)2.59359052
132cellular sodium ion homeostasis (GO:0006883)2.58742058
133flavonoid metabolic process (GO:0009812)2.49843523
134negative regulation of neurotransmitter transport (GO:0051589)2.48637817
135eye photoreceptor cell differentiation (GO:0001754)2.46259481
136photoreceptor cell differentiation (GO:0046530)2.46259481
137presynaptic membrane organization (GO:0097090)2.45514739
138cell communication by electrical coupling (GO:0010644)2.44241821
139negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.39929536
140Notch signaling involved in heart development (GO:0061314)2.39202879
141oxidative demethylation (GO:0070989)2.37932730
142regulation of relaxation of muscle (GO:1901077)2.35045381
143cell communication involved in cardiac conduction (GO:0086065)2.34031050
144negative regulation of neurotransmitter secretion (GO:0046929)2.32508672
145postsynaptic membrane organization (GO:0001941)2.32415042
146regulation of actin filament-based movement (GO:1903115)2.32262240
147glycoside metabolic process (GO:0016137)2.30957912
148regulation of cardiac muscle cell contraction (GO:0086004)2.28684692
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27704391
150sodium ion homeostasis (GO:0055078)2.24237473
151suckling behavior (GO:0001967)2.23856911
152carnitine shuttle (GO:0006853)2.22360005
153negative regulation of dendrite morphogenesis (GO:0050774)2.22065186
154neuron cell-cell adhesion (GO:0007158)2.21929733
155acidic amino acid transport (GO:0015800)2.19850284
156positive regulation of vascular permeability (GO:0043117)2.17268491
157phenylpropanoid metabolic process (GO:0009698)2.16287747
158activation of MAPKKK activity (GO:0000185)2.16016203
159positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.15061623
160L-amino acid import (GO:0043092)2.14969812
161regulation of short-term neuronal synaptic plasticity (GO:0048172)2.13357084
162glutamate receptor signaling pathway (GO:0007215)2.12212561
163astrocyte development (GO:0014002)2.12145720
164regulation of lipoprotein metabolic process (GO:0050746)2.11800882
165startle response (GO:0001964)2.11715992
166xenobiotic catabolic process (GO:0042178)2.11057696
167neuron recognition (GO:0008038)2.09729154
168hormone catabolic process (GO:0042447)2.08957914
169axonal fasciculation (GO:0007413)2.08161128
170glutamate secretion (GO:0014047)2.07177864
171androgen metabolic process (GO:0008209)2.05620429
172potassium ion homeostasis (GO:0055075)2.05561629
173peroxisome fission (GO:0016559)2.05237576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.13987607
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.58197324
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47237039
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.36098057
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.32232930
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.21507750
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50647334
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.49039737
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.47925816
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70490968
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98013217
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.80135629
13FOXA2_19822575_ChIP-Seq_HepG2_Human1.66697246
14* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62235761
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57249105
16HTT_18923047_ChIP-ChIP_STHdh_Human1.57188374
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.56413157
18TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48598215
19* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48362788
20AHR_22903824_ChIP-Seq_MCF-7_Human1.46675445
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.46421038
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.43892780
23TAF15_26573619_Chip-Seq_HEK293_Human1.37454862
24ER_23166858_ChIP-Seq_MCF-7_Human1.37166168
25CLOCK_20551151_ChIP-Seq_293T_Human1.36901492
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33007015
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31387568
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31063830
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30296498
30TP53_16413492_ChIP-PET_HCT116_Human1.29589133
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.28796345
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.27928588
33P53_22387025_ChIP-Seq_ESCs_Mouse1.26093622
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25868316
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.24787365
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24778267
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24608099
38IGF1R_20145208_ChIP-Seq_DFB_Human1.23751064
39CJUN_26792858_Chip-Seq_BT549_Human1.23741988
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22826019
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22540186
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22540186
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.19740890
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19042027
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19032723
46FUS_26573619_Chip-Seq_HEK293_Human1.18327010
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15453009
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.13587202
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.13324465
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12220236
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.12082147
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.11236075
53TCF4_23295773_ChIP-Seq_U87_Human1.10929844
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.10857104
55YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09971261
56EZH2_22144423_ChIP-Seq_EOC_Human1.09740629
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.09658644
58* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09526530
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.09432629
60GBX2_23144817_ChIP-Seq_PC3_Human1.08487057
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08159663
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08073044
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.07267369
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06938798
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06337603
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01588068
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.01463793
68* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01348106
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00996257
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00262048
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.00052435
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99375246
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98954134
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98568392
75* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98116486
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97841423
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97604986
78ESR2_21235772_ChIP-Seq_MCF-7_Human0.97517500
79GATA1_22025678_ChIP-Seq_K562_Human0.97485769
80ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96447584
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94594861
82BCAT_22108803_ChIP-Seq_LS180_Human0.93775202
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93672923
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93171583
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.92856214
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88062285
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85648466
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84446917
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83197403
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81836519
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81101671
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80543733
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79637303
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78708878
95* FOXA1_25552417_ChIP-Seq_VCAP_Human0.77395227
96* GATA4_25053715_ChIP-Seq_YYC3_Human0.77033217
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76980188
98P300_19829295_ChIP-Seq_ESCs_Human0.74188873
99* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74051776
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73108213
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.73073538
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73035650
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72667024
104SMAD4_21799915_ChIP-Seq_A2780_Human0.72653201
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71295350
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71016102
107POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70896123
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69549395
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69545549
110CDX2_22108803_ChIP-Seq_LS180_Human0.69182144
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68846914
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68202476
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68113819
114RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67256628
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67070143
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66986139
117CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66431248
118* CBP_21632823_ChIP-Seq_H3396_Human0.66430366
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.66241076
120STAT3_23295773_ChIP-Seq_U87_Human0.66056046
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.65806241
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.65582839
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.64356205
124TP63_23658742_ChIP-Seq_EP156T_Human0.64197893
125SOX2_20726797_ChIP-Seq_SW620_Human0.64087579
126* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.63832647
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63750632
128AR_21572438_ChIP-Seq_LNCaP_Human0.63550227
129AR_25329375_ChIP-Seq_VCAP_Human0.63409958
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.63372322
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.62879842
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.62161085
133CTBP2_25329375_ChIP-Seq_LNCAP_Human0.61911559
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.61770739
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61562693
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61350431
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.61297921
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.61228294
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.61218881
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59729449
141KDM2B_26808549_Chip-Seq_REH_Human0.59438828
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59299481
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.58985805
144CBP_20019798_ChIP-Seq_JUKART_Human0.58757455
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.58757455
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.58463832
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.57725581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.94994336
2MP0005360_urolithiasis7.16694022
3MP0005085_abnormal_gallbladder_physiolo6.19552885
4MP0005365_abnormal_bile_salt5.92597667
5MP0008875_abnormal_xenobiotic_pharmacok4.93770140
6MP0003252_abnormal_bile_duct3.83436233
7MP0003806_abnormal_nucleotide_metabolis3.62666372
8MP0010329_abnormal_lipoprotein_level3.41219944
9MP0002638_abnormal_pupillary_reflex3.08272079
10MP0003195_calcinosis3.04511998
11MP0005083_abnormal_biliary_tract2.92566149
12MP0009840_abnormal_foam_cell2.75723496
13MP0005332_abnormal_amino_acid2.74057807
14MP0001666_abnormal_nutrient_absorption2.54800152
15MP0000569_abnormal_digit_pigmentation2.45288240
16MP0000013_abnormal_adipose_tissue2.42617177
17MP0005623_abnormal_meninges_morphology2.22505794
18MP0004859_abnormal_synaptic_plasticity2.22240465
19MP0002118_abnormal_lipid_homeostasis2.15215966
20MP0004019_abnormal_vitamin_homeostasis2.08810308
21MP0003191_abnormal_cellular_cholesterol2.08510824
22MP0003868_abnormal_feces_composition2.00763318
23MP0000609_abnormal_liver_physiology1.94668858
24MP0003880_abnormal_central_pattern1.86511586
25MP0002138_abnormal_hepatobiliary_system1.83362327
26MP0004484_altered_response_of1.77577255
27MP0005423_abnormal_somatic_nervous1.62683281
28MP0005319_abnormal_enzyme/_coenzyme1.60509722
29MP0002064_seizures1.60241354
30MP0003635_abnormal_synaptic_transmissio1.59433128
31MP0001486_abnormal_startle_reflex1.57799115
32MP0003183_abnormal_peptide_metabolism1.57190249
33MP0005584_abnormal_enzyme/coenzyme_acti1.55022725
34MP0004885_abnormal_endolymph1.52345416
35MP0001764_abnormal_homeostasis1.46675946
36MP0002063_abnormal_learning/memory/cond1.45204479
37MP0000778_abnormal_nervous_system1.44902294
38MP0009697_abnormal_copulation1.44047724
39MP0004215_abnormal_myocardial_fiber1.42123472
40MP0005451_abnormal_body_composition1.41877251
41MP0005257_abnormal_intraocular_pressure1.41750415
42MP0002272_abnormal_nervous_system1.39488420
43MP0004924_abnormal_behavior1.36994703
44MP0005386_behavior/neurological_phenoty1.36994703
45MP0002572_abnormal_emotion/affect_behav1.35227156
46MP0000604_amyloidosis1.33760919
47MP0002009_preneoplasia1.33534884
48MP0003221_abnormal_cardiomyocyte_apopto1.32991853
49MP0002735_abnormal_chemical_nociception1.30711549
50MP0010678_abnormal_skin_adnexa1.29881461
51MP0003690_abnormal_glial_cell1.25758370
52MP0009643_abnormal_urine_homeostasis1.24773497
53MP0000749_muscle_degeneration1.24529424
54MP0009046_muscle_twitch1.24040434
55MP0000750_abnormal_muscle_regeneration1.23442083
56MP0002876_abnormal_thyroid_physiology1.22634874
57MP0002734_abnormal_mechanical_nocicepti1.22020290
58MP0009745_abnormal_behavioral_response1.20735766
59MP0003329_amyloid_beta_deposits1.20710389
60MP0002067_abnormal_sensory_capabilities1.19111485
61MP0002269_muscular_atrophy1.15662486
62MP0003656_abnormal_erythrocyte_physiolo1.13314504
63MP0005647_abnormal_sex_gland1.12944115
64MP0002877_abnormal_melanocyte_morpholog1.12367424
65MP0003011_delayed_dark_adaptation1.09485557
66MP0004130_abnormal_muscle_cell1.02930657
67MP0002972_abnormal_cardiac_muscle1.02809174
68MP0004087_abnormal_muscle_fiber1.02006280
69MP0005408_hypopigmentation1.01317302
70MP0003186_abnormal_redox_activity1.00476999
71MP0002332_abnormal_exercise_endurance1.00359450
72MP0001440_abnormal_grooming_behavior0.98407521
73MP0005535_abnormal_body_temperature0.98191861
74MP0003634_abnormal_glial_cell0.97065637
75MP0009764_decreased_sensitivity_to0.96579075
76MP0002254_reproductive_system_inflammat0.95967545
77MP0005636_abnormal_mineral_homeostasis0.94061159
78MP0000462_abnormal_digestive_system0.94029206
79MP0000598_abnormal_liver_morphology0.92896622
80MP0002078_abnormal_glucose_homeostasis0.91892341
81MP0001502_abnormal_circadian_rhythm0.91517258
82MP0001661_extended_life_span0.90575261
83MP0005620_abnormal_muscle_contractility0.90098313
84MP0001501_abnormal_sleep_pattern0.88979956
85MP0001727_abnormal_embryo_implantation0.88439732
86MP0003787_abnormal_imprinting0.88032795
87MP0002971_abnormal_brown_adipose0.87981524
88MP0000003_abnormal_adipose_tissue0.87219800
89MP0002822_catalepsy0.86836123
90MP0004043_abnormal_pH_regulation0.86323393
91MP0000383_abnormal_hair_follicle0.85783613
92MP0003137_abnormal_impulse_conducting0.85554763
93MP0000751_myopathy0.85405792
94MP0003705_abnormal_hypodermis_morpholog0.85178115
95MP0008569_lethality_at_weaning0.83463551
96MP0003283_abnormal_digestive_organ0.81756788
97MP0004811_abnormal_neuron_physiology0.81706746
98MP0005084_abnormal_gallbladder_morpholo0.81697414
99MP0002066_abnormal_motor_capabilities/c0.81271408
100MP0000747_muscle_weakness0.80239326
101MP0009763_increased_sensitivity_to0.79803109
102MP0005367_renal/urinary_system_phenotyp0.79738810
103MP0000516_abnormal_urinary_system0.79738810
104MP0009642_abnormal_blood_homeostasis0.79360352
105MP0004084_abnormal_cardiac_muscle0.79257992
106MP0000639_abnormal_adrenal_gland0.75251500
107MP0002557_abnormal_social/conspecific_i0.74937096
108MP0005220_abnormal_exocrine_pancreas0.74076815
109MP0005334_abnormal_fat_pad0.73573356
110MP0003879_abnormal_hair_cell0.72280950
111MP0004142_abnormal_muscle_tone0.71650814
112MP0009780_abnormal_chondrocyte_physiolo0.71086380
113MP0002882_abnormal_neuron_morphology0.70730416
114MP0001756_abnormal_urination0.70424735
115MP0010368_abnormal_lymphatic_system0.70008979
116MP0005670_abnormal_white_adipose0.69763283
117MP0009765_abnormal_xenobiotic_induced0.69073314
118MP0005376_homeostasis/metabolism_phenot0.68122282
119MP0005448_abnormal_energy_balance0.65118903
120MP0008469_abnormal_protein_level0.64084094
121MP0002837_dystrophic_cardiac_calcinosis0.62972857
122MP0002090_abnormal_vision0.62177995
123MP0006036_abnormal_mitochondrial_physio0.61928491
124MP0008874_decreased_physiological_sensi0.56231562
125MP0005058_abnormal_lysosome_morphology0.56017255
126MP0005666_abnormal_adipose_tissue0.53611743
127MP0010234_abnormal_vibrissa_follicle0.52511351
128MP0003953_abnormal_hormone_level0.52492858
129MP0002928_abnormal_bile_duct0.52339833
130MP0000230_abnormal_systemic_arterial0.52088864
131MP0000579_abnormal_nail_morphology0.50407758
132MP0000920_abnormal_myelination0.50102218
133MP0004782_abnormal_surfactant_physiolog0.48705884
134MP0002168_other_aberrant_phenotype0.48297912
135MP0005266_abnormal_metabolism0.47925781
136MP0002909_abnormal_adrenal_gland0.46726580
137MP0003075_altered_response_to0.46696301
138MP0003633_abnormal_nervous_system0.46431461
139MP0009384_cardiac_valve_regurgitation0.45524832
140MP0005395_other_phenotype0.44898117
141MP0003638_abnormal_response/metabolism_0.43053010
142MP0001765_abnormal_ion_homeostasis0.42718969
143MP0002136_abnormal_kidney_physiology0.42618876
144MP0002295_abnormal_pulmonary_circulatio0.41553676
145MP0005248_abnormal_Harderian_gland0.40605527
146MP0003632_abnormal_nervous_system0.38740172
147MP0005166_decreased_susceptibility_to0.38088855
148MP0001177_atelectasis0.37997764
149MP0003631_nervous_system_phenotype0.37874465
150MP0004185_abnormal_adipocyte_glucose0.37778602
151MP0008872_abnormal_physiological_respon0.37428056
152MP0002796_impaired_skin_barrier0.37350169
153MP0006035_abnormal_mitochondrial_morpho0.37308375
154MP0001984_abnormal_olfaction0.36745966
155MP0004270_analgesia0.35652975
156MP0003300_gastrointestinal_ulcer0.35614290
157MP0005646_abnormal_pituitary_gland0.35297162
158MP0005187_abnormal_penis_morphology0.35167002
159MP0005551_abnormal_eye_electrophysiolog0.35165391
160MP0004883_abnormal_blood_vessel0.34619175

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.12842343
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.95503571
3Deep venous thrombosis (HP:0002625)6.86667224
4Xanthomatosis (HP:0000991)5.98946369
5Prolonged partial thromboplastin time (HP:0003645)5.95423218
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.94466777
7Hypobetalipoproteinemia (HP:0003563)5.67125957
8Hyperlipoproteinemia (HP:0010980)5.27968822
9Complement deficiency (HP:0004431)5.12932598
10Epidermoid cyst (HP:0200040)4.50719268
11Retinal atrophy (HP:0001105)4.33004413
12Hypolipoproteinemia (HP:0010981)4.27229412
13Hyperammonemia (HP:0001987)4.24709205
14Hyperglycinemia (HP:0002154)4.20963125
15Ketosis (HP:0001946)4.20150087
16Joint hemorrhage (HP:0005261)4.18816567
17Abnormality of the common coagulation pathway (HP:0010990)4.14884241
18Fat malabsorption (HP:0002630)4.08565438
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.03077469
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01432124
21Hypoglycemic coma (HP:0001325)3.84935776
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.83848645
23Abnormality of serine family amino acid metabolism (HP:0010894)3.83285784
24Abnormality of glycine metabolism (HP:0010895)3.83285784
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.82036134
26Abnormality of methionine metabolism (HP:0010901)3.79501971
27Conjugated hyperbilirubinemia (HP:0002908)3.79120309
28Hypoalphalipoproteinemia (HP:0003233)3.77171510
29Hyperglycinuria (HP:0003108)3.76579929
30Abnormality of complement system (HP:0005339)3.61901706
31Abnormality of the intrinsic pathway (HP:0010989)3.57162831
32Hypercholesterolemia (HP:0003124)3.39155417
33Cerebellar dysplasia (HP:0007033)3.30999477
34Ketoacidosis (HP:0001993)3.28679605
35Abnormality of fatty-acid metabolism (HP:0004359)3.18010366
36Increased circulating renin level (HP:0000848)3.11435874
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10137650
38Steatorrhea (HP:0002570)3.03515501
39Action tremor (HP:0002345)3.01649507
40Hyperbilirubinemia (HP:0002904)3.00255905
41Myocardial infarction (HP:0001658)2.88022649
42Bundle branch block (HP:0011710)2.87588811
43Abnormality of serum amino acid levels (HP:0003112)2.83791097
44Skin nodule (HP:0200036)2.83540035
45Pheochromocytoma (HP:0002666)2.83172541
46Delayed CNS myelination (HP:0002188)2.82688530
47Papillary thyroid carcinoma (HP:0002895)2.81959417
48Abnormality of pyrimidine metabolism (HP:0004353)2.76040745
49Exercise-induced muscle cramps (HP:0003710)2.75241837
50Abnormality of nucleobase metabolism (HP:0010932)2.74794051
51Abnormality of purine metabolism (HP:0004352)2.74170705
52Hepatocellular carcinoma (HP:0001402)2.70894719
53Vascular calcification (HP:0004934)2.69131795
54Hypoglycemic seizures (HP:0002173)2.68398506
55Gout (HP:0001997)2.67278246
56Hypochromic microcytic anemia (HP:0004840)2.65849833
57Spontaneous abortion (HP:0005268)2.63136866
58Hyporeflexia of lower limbs (HP:0002600)2.62411354
59Acanthocytosis (HP:0001927)2.60600962
60Metabolic acidosis (HP:0001942)2.59043775
61Epileptiform EEG discharges (HP:0011182)2.54801716
62Focal motor seizures (HP:0011153)2.51573366
63Gowers sign (HP:0003391)2.50743332
64EEG with generalized epileptiform discharges (HP:0011198)2.49492707
65Atonic seizures (HP:0010819)2.49385292
66Difficulty climbing stairs (HP:0003551)2.48696454
67Neuroendocrine neoplasm (HP:0100634)2.47092442
68Abnormal gallbladder morphology (HP:0012437)2.46539436
69Sensorimotor neuropathy (HP:0007141)2.45726198
70Hypsarrhythmia (HP:0002521)2.43669260
71Systemic lupus erythematosus (HP:0002725)2.43497529
72Myoglobinuria (HP:0002913)2.41510764
73Cardiovascular calcification (HP:0011915)2.40251331
74Lethargy (HP:0001254)2.38214195
75Mitral stenosis (HP:0001718)2.37666098
76Fatigue (HP:0012378)2.36434767
77Irritability (HP:0000737)2.35127736
78Sudden death (HP:0001699)2.33908709
79Frequent falls (HP:0002359)2.33324885
80Type II lissencephaly (HP:0007260)2.32395305
81Difficulty running (HP:0009046)2.30897578
82Dicarboxylic aciduria (HP:0003215)2.30081348
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30081348
84Hyperinsulinemic hypoglycemia (HP:0000825)2.28630289
85Cholecystitis (HP:0001082)2.28049312
86Abnormal gallbladder physiology (HP:0012438)2.28049312
87Cholelithiasis (HP:0001081)2.26854601
88Scanning speech (HP:0002168)2.25458132
89Papilledema (HP:0001085)2.25062384
90Hyperventilation (HP:0002883)2.24118176
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22719137
92Neonatal onset (HP:0003623)2.20471735
93Glomerulonephritis (HP:0000099)2.19993489
94Cerebral edema (HP:0002181)2.19922203
95Abnormality of the left ventricular outflow tract (HP:0011103)2.18136196
96Subaortic stenosis (HP:0001682)2.18136196
97Amyloidosis (HP:0011034)2.15769612
98Malnutrition (HP:0004395)2.15061253
99Atrioventricular block (HP:0001678)2.12280244
100Recurrent gram-negative bacterial infections (HP:0005420)2.09246529
101Blue irides (HP:0000635)2.08617073
102Fair hair (HP:0002286)2.07982943
103Buphthalmos (HP:0000557)2.07748795
104Spastic diplegia (HP:0001264)2.07043195
105Hydroxyprolinuria (HP:0003080)2.05114496
106Abnormality of proline metabolism (HP:0010907)2.05114496
107Abnormal eating behavior (HP:0100738)2.04699966
108Pancreatitis (HP:0001733)2.04653053
109Hypophosphatemic rickets (HP:0004912)2.04497282
110Alkalosis (HP:0001948)2.03401008
111Enlarged kidneys (HP:0000105)2.03186981
112Intention tremor (HP:0002080)2.03096625
113Metabolic alkalosis (HP:0200114)2.02998791
114Rickets (HP:0002748)2.02992962
115Hyperglycemia (HP:0003074)2.02210659
116Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01825676
117Neurofibrillary tangles (HP:0002185)2.01318382
118Brushfield spots (HP:0001088)2.00685738
119Febrile seizures (HP:0002373)1.99760230
120Abnormality of the gallbladder (HP:0005264)1.99283432
121Esophageal varix (HP:0002040)1.97855149
122Tetraparesis (HP:0002273)1.97758079
123Thyroid carcinoma (HP:0002890)1.97624723
124Hemorrhage of the eye (HP:0011885)1.97116052
125Curly hair (HP:0002212)1.96974237
126Glycosuria (HP:0003076)1.95990614
127Abnormality of urine glucose concentration (HP:0011016)1.95990614
128EMG: myopathic abnormalities (HP:0003458)1.95154740
129Retinal dysplasia (HP:0007973)1.94373345
130Ankle clonus (HP:0011448)1.94275813
131Vomiting (HP:0002013)1.93734922
132Generalized aminoaciduria (HP:0002909)1.92328537
133Syncope (HP:0001279)1.91616779
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90914819
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.90914819
136Limb dystonia (HP:0002451)1.90557793
137Status epilepticus (HP:0002133)1.90378799
138Akinesia (HP:0002304)1.89013083
139Supranuclear gaze palsy (HP:0000605)1.87708701
140Abnormality of vision evoked potentials (HP:0000649)1.86325623
141Heart block (HP:0012722)1.85507715
142Symptomatic seizures (HP:0011145)1.84643915
143Late onset (HP:0003584)1.82036265
144Abnormal enzyme/coenzyme activity (HP:0012379)1.81894914
145Muscle fiber inclusion bodies (HP:0100299)1.81263789
146Nemaline bodies (HP:0003798)1.80530180
147Abnormality of the calf musculature (HP:0001430)1.79709822
148Drooling (HP:0002307)1.79272749
149Polyphagia (HP:0002591)1.78868064
150Abnormality of vitamin metabolism (HP:0100508)1.78750903
151Renal cortical cysts (HP:0000803)1.78251128
152Increased purine levels (HP:0004368)1.77887487
153Hyperuricemia (HP:0002149)1.77887487
154Hypothermia (HP:0002045)1.76696419
155Generalized hypopigmentation of hair (HP:0011358)1.76273034
156Menorrhagia (HP:0000132)1.74958368
157Abnormality of the corticospinal tract (HP:0002492)1.74127618
158Cerebral hemorrhage (HP:0001342)1.74060498
159Insulin-resistant diabetes mellitus (HP:0000831)1.73158887
160Hemiplegia (HP:0002301)1.72339964
161Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71917755
162Increased serum pyruvate (HP:0003542)1.71757854
163Cerebral inclusion bodies (HP:0100314)1.70919978
164Abnormality of glycolysis (HP:0004366)1.70876098
165Congenital glaucoma (HP:0001087)1.70489048
166Opisthotonus (HP:0002179)1.68984092
167Poikilocytosis (HP:0004447)1.67650521
168Confusion (HP:0001289)1.67155376
169Proximal tubulopathy (HP:0000114)1.66817662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.78277342
2INSRR3.21108456
3SIK13.10905908
4FRK3.04705349
5FGFR42.97758763
6TAOK32.92532585
7ERBB32.83632398
8ERBB42.59645526
9TNIK2.55617228
10MAP2K42.53311098
11LATS12.22257277
12FGFR22.13049017
13ERN12.03693351
14OBSCN1.97724904
15MAP3K121.91526958
16PHKG11.79883829
17PHKG21.79883829
18DAPK21.76854626
19STK391.63814609
20MARK31.51135534
21EPHA41.50874756
22MAP3K21.46344633
23MST1R1.40949756
24PIK3CG1.40034032
25OXSR11.38631687
26NEK91.38618680
27KSR11.37823470
28NTRK21.35203510
29MAP3K41.34712890
30SCYL21.34401742
31SGK2231.33894827
32SGK4941.33894827
33CAMKK21.32007418
34EPHB11.29703832
35STK38L1.28517032
36MUSK1.25913420
37WNK41.24122073
38PINK11.22373720
39PTK2B1.21127309
40PNCK1.20344267
41BMPR21.20272793
42ABL21.15073174
43KSR21.14534754
44NTRK11.13310807
45CAMK1D1.11932982
46PRKCE1.09795228
47SGK31.09642343
48STK101.08822344
49YES11.06375736
50SGK21.05865267
51RET1.05338668
52JAK21.04787640
53PAK31.04538120
54MAP4K21.02654225
55PRKAA21.01012711
56PLK21.00605416
57CSNK1G20.99501440
58LMTK20.98491838
59CAMK2D0.98461776
60MET0.98276404
61MAPK110.95987487
62MAP3K70.95412634
63CAMK1G0.95038700
64RIPK10.94093198
65PKN10.92026043
66MAPK130.91675466
67NEK60.91417422
68UHMK10.90982758
69AKT30.90712473
70ROCK20.88612605
71JAK10.87953244
72PRKCZ0.87769481
73CAMK2G0.86583119
74MOS0.83363492
75PDPK10.82393927
76EPHA30.81772634
77CSNK1G10.81666058
78PTK60.79036824
79STK110.78385636
80PRKAA10.77881809
81MAP2K70.75642830
82PRKCQ0.74829445
83CDK50.74729132
84CSNK1G30.73682322
85STK240.72024612
86MAPK150.68857116
87ERBB20.67259802
88PRKACG0.67102206
89MAP2K10.66812079
90PDK30.66700209
91PDK40.66700209
92PAK60.66663444
93PRKCH0.65926751
94NUAK10.65879391
95TYK20.65416654
96MAPK70.65286924
97CSNK1A1L0.65153851
98EPHA20.64950691
99PTK20.64715595
100LATS20.62207920
101NTRK30.61986466
102CAMKK10.61632451
103NEK10.60581452
104MAP3K130.60367440
105GRK50.60188553
106EPHB20.60174794
107FER0.59123727
108PRKCG0.58559171
109GSK3A0.57528269
110IRAK20.57477582
111MINK10.56499789
112FGFR30.56460015
113TRIB30.56431997
114WNK30.55764204
115CASK0.55571278
116PKN20.54796385
117PDK10.54296469
118PBK0.53466937
119RPS6KB10.53029160
120PDK20.52242671
121SIK20.52158878
122MAP3K10.52051516
123IRAK10.51958966
124DYRK1B0.50991328
125MAP3K60.50800498
126MAP3K90.48247499
127CAMK2A0.48088455
128SGK10.47915180
129BCR0.47868843
130ACVR1B0.47646508
131CAMK2B0.46613291
132IGF1R0.46503604
133TIE10.46267593
134FLT30.45689806
135STK380.45544176
136PIK3CA0.45505834
137MAPK120.45456051
138MAP3K50.44315180
139MARK10.44217060
140WNK10.44084913
141MAP3K140.43688322
142DYRK1A0.43429554
143HIPK20.41560252
144SIK30.40146119

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32946010
2Nitrogen metabolism_Homo sapiens_hsa009103.91062413
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09486203
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06311619
5Arginine biosynthesis_Homo sapiens_hsa002202.90543711
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75384182
7Tryptophan metabolism_Homo sapiens_hsa003802.57860516
8Complement and coagulation cascades_Homo sapiens_hsa046102.51634619
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46757262
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43382496
11Fatty acid degradation_Homo sapiens_hsa000712.43058835
12Butanoate metabolism_Homo sapiens_hsa006502.38592280
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31600545
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06503462
15Peroxisome_Homo sapiens_hsa041462.04995124
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03751527
17Propanoate metabolism_Homo sapiens_hsa006402.02823852
18Histidine metabolism_Homo sapiens_hsa003401.92836641
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91500955
20PPAR signaling pathway_Homo sapiens_hsa033201.89949023
21Fatty acid metabolism_Homo sapiens_hsa012121.87468641
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82166315
23Chemical carcinogenesis_Homo sapiens_hsa052041.75999049
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75378140
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73743124
26beta-Alanine metabolism_Homo sapiens_hsa004101.69630687
27Caffeine metabolism_Homo sapiens_hsa002321.63448247
28Sulfur metabolism_Homo sapiens_hsa009201.63221275
29Bile secretion_Homo sapiens_hsa049761.59856576
30Retinol metabolism_Homo sapiens_hsa008301.58334981
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54098944
32Fatty acid elongation_Homo sapiens_hsa000621.52661419
33Phenylalanine metabolism_Homo sapiens_hsa003601.49947114
34Staphylococcus aureus infection_Homo sapiens_hsa051501.49320613
35Steroid biosynthesis_Homo sapiens_hsa001001.43656772
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.41562078
37Tyrosine metabolism_Homo sapiens_hsa003501.37941674
38Pyruvate metabolism_Homo sapiens_hsa006201.33774724
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28863071
40Amphetamine addiction_Homo sapiens_hsa050311.28111217
41Starch and sucrose metabolism_Homo sapiens_hsa005001.25709940
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24275011
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22496015
44Selenocompound metabolism_Homo sapiens_hsa004501.22385818
45ABC transporters_Homo sapiens_hsa020101.20082351
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.17453910
47Fat digestion and absorption_Homo sapiens_hsa049751.09579222
48Vitamin B6 metabolism_Homo sapiens_hsa007501.09494836
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09292368
50Dopaminergic synapse_Homo sapiens_hsa047281.06617634
51Long-term potentiation_Homo sapiens_hsa047201.03620388
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.03539698
53Nicotine addiction_Homo sapiens_hsa050331.02689243
54Glutamatergic synapse_Homo sapiens_hsa047240.98237037
55Folate biosynthesis_Homo sapiens_hsa007900.96169638
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94448081
57Circadian entrainment_Homo sapiens_hsa047130.93042185
58Carbon metabolism_Homo sapiens_hsa012000.92355065
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89974855
60Arginine and proline metabolism_Homo sapiens_hsa003300.88297097
61Biosynthesis of amino acids_Homo sapiens_hsa012300.87215711
62Vitamin digestion and absorption_Homo sapiens_hsa049770.86997768
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86494995
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83176867
65Renin secretion_Homo sapiens_hsa049240.77264405
66Glycerolipid metabolism_Homo sapiens_hsa005610.77198909
67Fatty acid biosynthesis_Homo sapiens_hsa000610.70514852
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69656530
69Dorso-ventral axis formation_Homo sapiens_hsa043200.68723860
70Lysine degradation_Homo sapiens_hsa003100.66511694
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63445604
72Serotonergic synapse_Homo sapiens_hsa047260.63068900
73Sulfur relay system_Homo sapiens_hsa041220.60072700
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.60004199
75Long-term depression_Homo sapiens_hsa047300.59472755
76Gastric acid secretion_Homo sapiens_hsa049710.57933850
77Pancreatic secretion_Homo sapiens_hsa049720.57522290
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55331611
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54331972
80Glutathione metabolism_Homo sapiens_hsa004800.53335327
81Synaptic vesicle cycle_Homo sapiens_hsa047210.52815793
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52591139
83Salivary secretion_Homo sapiens_hsa049700.50066994
84Cholinergic synapse_Homo sapiens_hsa047250.48491432
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48049027
86Prion diseases_Homo sapiens_hsa050200.46742018
87Sphingolipid metabolism_Homo sapiens_hsa006000.46109368
88Estrogen signaling pathway_Homo sapiens_hsa049150.44855260
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44533374
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42621120
91cAMP signaling pathway_Homo sapiens_hsa040240.41278113
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41167582
93Renin-angiotensin system_Homo sapiens_hsa046140.40629007
94Protein digestion and absorption_Homo sapiens_hsa049740.39271042
95Metabolic pathways_Homo sapiens_hsa011000.38318071
96Arachidonic acid metabolism_Homo sapiens_hsa005900.37225493
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34865187
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.31813262
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29877639
100Insulin resistance_Homo sapiens_hsa049310.28426800
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.27370500
102Linoleic acid metabolism_Homo sapiens_hsa005910.26952353
103Pentose phosphate pathway_Homo sapiens_hsa000300.26520443
104Glucagon signaling pathway_Homo sapiens_hsa049220.17267251
105Ovarian steroidogenesis_Homo sapiens_hsa049130.15140958
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11151319
107AMPK signaling pathway_Homo sapiens_hsa041520.09979428
108Fructose and mannose metabolism_Homo sapiens_hsa000510.06422159
109Galactose metabolism_Homo sapiens_hsa000520.05822736
110Thyroid hormone synthesis_Homo sapiens_hsa049180.04665765
111GABAergic synapse_Homo sapiens_hsa047270.04497477
112Type II diabetes mellitus_Homo sapiens_hsa049300.03128023
113Ether lipid metabolism_Homo sapiens_hsa005650.02125018
114One carbon pool by folate_Homo sapiens_hsa006700.00270839
115Circadian rhythm_Homo sapiens_hsa04710-0.1413738
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1370294
117Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1276049
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1267835
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1237034
120Cocaine addiction_Homo sapiens_hsa05030-0.1191362
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1176903
122Insulin secretion_Homo sapiens_hsa04911-0.0916124
123Mineral absorption_Homo sapiens_hsa04978-0.0858462
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0852959
125Lysosome_Homo sapiens_hsa04142-0.0798324
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0326581
127Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0243133
128Insulin signaling pathway_Homo sapiens_hsa04910-0.0208791
129Regulation of autophagy_Homo sapiens_hsa04140-0.0063492

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