ACADVL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.66974478
2lysine catabolic process (GO:0006554)5.66974478
3L-phenylalanine catabolic process (GO:0006559)5.53344225
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53344225
5L-phenylalanine metabolic process (GO:0006558)5.41343695
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.41343695
7* fatty acid beta-oxidation (GO:0006635)5.08808411
8fatty acid transmembrane transport (GO:1902001)5.08493327
9carnitine shuttle (GO:0006853)5.06266673
10alpha-linolenic acid metabolic process (GO:0036109)4.96702216
11glyoxylate metabolic process (GO:0046487)4.95548691
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87182583
13aromatic amino acid family catabolic process (GO:0009074)4.82310579
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81769996
15tricarboxylic acid cycle (GO:0006099)4.78551672
16regulation of triglyceride catabolic process (GO:0010896)4.74418091
172-oxoglutarate metabolic process (GO:0006103)4.73115356
18regulation of sequestering of triglyceride (GO:0010889)4.65558735
19amino-acid betaine metabolic process (GO:0006577)4.65325957
20acetyl-CoA metabolic process (GO:0006084)4.64881817
21* fatty acid oxidation (GO:0019395)4.63189817
22kynurenine metabolic process (GO:0070189)4.61938741
23cellular ketone body metabolic process (GO:0046950)4.58762621
24* fatty acid catabolic process (GO:0009062)4.56621163
25* lipid oxidation (GO:0034440)4.55114388
26aspartate family amino acid catabolic process (GO:0009068)4.51352448
27short-chain fatty acid metabolic process (GO:0046459)4.42108921
28positive regulation of fatty acid beta-oxidation (GO:0032000)4.29738095
29bile acid biosynthetic process (GO:0006699)4.29087460
30carnitine metabolic process (GO:0009437)4.27587241
31branched-chain amino acid catabolic process (GO:0009083)4.25373480
32tryptophan catabolic process (GO:0006569)4.24129131
33indole-containing compound catabolic process (GO:0042436)4.24129131
34indolalkylamine catabolic process (GO:0046218)4.24129131
35sulfur amino acid catabolic process (GO:0000098)4.22507891
36* monocarboxylic acid catabolic process (GO:0072329)4.20865563
37cysteine metabolic process (GO:0006534)4.18705138
38valine metabolic process (GO:0006573)4.17752063
39biotin metabolic process (GO:0006768)4.14158511
40positive regulation of fatty acid oxidation (GO:0046321)4.05088907
41tryptophan metabolic process (GO:0006568)4.01960878
42urea cycle (GO:0000050)3.99819461
43urea metabolic process (GO:0019627)3.99819461
44carnitine transmembrane transport (GO:1902603)3.99603964
45NADH metabolic process (GO:0006734)3.96726301
46ketone body metabolic process (GO:1902224)3.95303109
47branched-chain amino acid metabolic process (GO:0009081)3.94599251
48mannose metabolic process (GO:0006013)3.91183121
49amino-acid betaine transport (GO:0015838)3.90645068
50carnitine transport (GO:0015879)3.90645068
51serine family amino acid catabolic process (GO:0009071)3.87417845
52negative regulation of fibrinolysis (GO:0051918)3.86285991
53alpha-amino acid catabolic process (GO:1901606)3.85239813
54ethanol oxidation (GO:0006069)3.84698714
55homocysteine metabolic process (GO:0050667)3.83807082
56complement activation, alternative pathway (GO:0006957)3.83657118
57acylglycerol homeostasis (GO:0055090)3.83467642
58triglyceride homeostasis (GO:0070328)3.83467642
59* regulation of fatty acid oxidation (GO:0046320)3.80572285
60tricarboxylic acid metabolic process (GO:0072350)3.79961695
61high-density lipoprotein particle remodeling (GO:0034375)3.78489698
62protein carboxylation (GO:0018214)3.76646094
63peptidyl-glutamic acid carboxylation (GO:0017187)3.76646094
64positive regulation of lipid catabolic process (GO:0050996)3.73960467
65regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.73944224
66plasma lipoprotein particle clearance (GO:0034381)3.72372521
67nitrogen cycle metabolic process (GO:0071941)3.72050047
68regulation of protein activation cascade (GO:2000257)3.69941366
69* organic acid catabolic process (GO:0016054)3.69754220
70* carboxylic acid catabolic process (GO:0046395)3.69754220
71cellular amino acid catabolic process (GO:0009063)3.67159511
72regulation of fibrinolysis (GO:0051917)3.65937084
73succinate metabolic process (GO:0006105)3.65685897
74bile acid metabolic process (GO:0008206)3.62260333
75regulation of fatty acid beta-oxidation (GO:0031998)3.61518558
76phospholipid homeostasis (GO:0055091)3.57434344
77coenzyme catabolic process (GO:0009109)3.54549291
78negative regulation of erythrocyte differentiation (GO:0045647)3.54028493
79oxaloacetate metabolic process (GO:0006107)3.50522143
80aromatic amino acid family metabolic process (GO:0009072)3.50230678
81dicarboxylic acid biosynthetic process (GO:0043650)3.49585685
82regulation of complement activation (GO:0030449)3.47910193
83plasma lipoprotein particle remodeling (GO:0034369)3.41324196
84protein-lipid complex remodeling (GO:0034368)3.41324196
85macromolecular complex remodeling (GO:0034367)3.41324196
86low-density lipoprotein particle clearance (GO:0034383)3.38811401
87reverse cholesterol transport (GO:0043691)3.38750985
88regulation of cholesterol esterification (GO:0010872)3.37446824
89tyrosine metabolic process (GO:0006570)3.36393462
90creatine metabolic process (GO:0006600)3.35815994
91regulation of acyl-CoA biosynthetic process (GO:0050812)3.34155494
92thioester metabolic process (GO:0035383)3.33540321
93acyl-CoA metabolic process (GO:0006637)3.33540321
94glutamate metabolic process (GO:0006536)3.30810823
95cellular modified amino acid catabolic process (GO:0042219)3.29237342
96quaternary ammonium group transport (GO:0015697)3.27499400
97thioester biosynthetic process (GO:0035384)3.27328907
98acyl-CoA biosynthetic process (GO:0071616)3.27328907
99negative regulation of lipase activity (GO:0060192)3.26482815
100positive regulation of triglyceride metabolic process (GO:0090208)3.23973891
101phospholipid efflux (GO:0033700)3.19935434
102actin-myosin filament sliding (GO:0033275)3.18993713
103muscle filament sliding (GO:0030049)3.18993713
104Golgi transport vesicle coating (GO:0048200)3.17604610
105COPI coating of Golgi vesicle (GO:0048205)3.17604610
106positive regulation of triglyceride lipase activity (GO:0061365)3.13041374
107positive regulation of lipoprotein lipase activity (GO:0051006)3.13041374
108fatty acid homeostasis (GO:0055089)3.12995152
109cellular glucuronidation (GO:0052695)3.12206006
110negative regulation of cholesterol transport (GO:0032375)3.10829179
111regulation of cholesterol homeostasis (GO:2000188)2.99824650
112barbed-end actin filament capping (GO:0051016)2.93580079
113pinocytosis (GO:0006907)2.81671045
114protein retention in ER lumen (GO:0006621)2.76222542
115negative regulation of cell size (GO:0045792)2.75277625
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75187313
117regulation of cholesterol storage (GO:0010885)2.74787798
118fructose metabolic process (GO:0006000)2.67022537
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64236831
120diacylglycerol metabolic process (GO:0046339)2.60741018
121angiotensin maturation (GO:0002003)2.57766520
122focal adhesion assembly (GO:0048041)2.57389295
123cell-substrate adherens junction assembly (GO:0007045)2.57389295
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.57060431
125basement membrane organization (GO:0071711)2.56308752
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56065426
127glycosphingolipid catabolic process (GO:0046479)2.55932418
128cardiac muscle contraction (GO:0060048)2.55894608
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54312780
130positive regulation of fatty acid biosynthetic process (GO:0045723)2.52719302
131actin-mediated cell contraction (GO:0070252)2.52553240
132regulation of cholesterol biosynthetic process (GO:0045540)2.51716009
133response to mercury ion (GO:0046689)2.51599760
134negative regulation of fatty acid transport (GO:2000192)2.51015654
135desmosome organization (GO:0002934)2.50573884
136regulation of necrotic cell death (GO:0010939)2.48918403
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48609763
138cell-substrate junction assembly (GO:0007044)2.46747621
139adhesion of symbiont to host (GO:0044406)2.46137344
140positive regulation of extracellular matrix organization (GO:1903055)2.45173129
141regulation of apoptotic cell clearance (GO:2000425)2.44914499
142protein-lipid complex assembly (GO:0065005)2.44102296
143epoxygenase P450 pathway (GO:0019373)2.43551290
144adherens junction assembly (GO:0034333)2.41818216
145negative regulation of necroptotic process (GO:0060546)2.40742248
146sarcomere organization (GO:0045214)2.38523795
147skeletal muscle adaptation (GO:0043501)2.37376174
148glycolipid catabolic process (GO:0019377)2.36938362
149cell volume homeostasis (GO:0006884)2.35544468
150stress fiber assembly (GO:0043149)2.35456564
151regulation of skeletal muscle contraction (GO:0014819)2.34997561
152regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.34232603
153epithelial cell-cell adhesion (GO:0090136)2.33793466
154actin filament depolymerization (GO:0030042)2.32850818
155gluconeogenesis (GO:0006094)2.32311978
156complement activation, classical pathway (GO:0006958)2.32053709
157triglyceride catabolic process (GO:0019433)2.30941578
158regulation of necroptotic process (GO:0060544)2.30780064
159very-low-density lipoprotein particle assembly (GO:0034379)2.30065442
160negative regulation of lipid transport (GO:0032369)2.28926911
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.27765742
162acylglycerol catabolic process (GO:0046464)2.27427813
163neutral lipid catabolic process (GO:0046461)2.27427813
164* regulation of fatty acid biosynthetic process (GO:0042304)2.27292520
165protein localization to endosome (GO:0036010)2.27008849
166proline biosynthetic process (GO:0006561)2.24910940
167actin filament-based movement (GO:0030048)2.24669242
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23854310
169response to thyroid hormone (GO:0097066)2.23753691
170apoptotic cell clearance (GO:0043277)2.23353014
171acute-phase response (GO:0006953)2.22632871
172renal filtration (GO:0097205)2.22092423
173GDP-mannose metabolic process (GO:0019673)2.20759800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.70874399
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.17074911
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.78809620
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.06302845
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.40399082
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.57833445
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.36445957
8* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.04977645
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.69490895
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.64856546
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.22846625
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58006485
13VDR_21846776_ChIP-Seq_THP-1_Human2.52449569
14CLOCK_20551151_ChIP-Seq_293T_Human2.51619819
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.33104164
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25185785
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13457789
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11860366
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06580718
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95189036
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91743018
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87182077
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.85910643
24ZNF263_19887448_ChIP-Seq_K562_Human1.80014213
25TCF7_22412390_ChIP-Seq_EML_Mouse1.76644829
26KDM2B_26808549_Chip-Seq_DND41_Human1.75999143
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75416184
28GATA1_22025678_ChIP-Seq_K562_Human1.71811073
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62725323
30P68_20966046_ChIP-Seq_HELA_Human1.61791746
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58539008
32MYC_22102868_ChIP-Seq_BL_Human1.57145779
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56469025
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.54297958
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.54297958
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.52437089
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50972716
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49781258
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.49605520
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48462251
41* TET1_21451524_ChIP-Seq_MESCs_Mouse1.48452036
42KDM2B_26808549_Chip-Seq_K562_Human1.46589715
43SMC4_20622854_ChIP-Seq_HELA_Human1.45954787
44VDR_24763502_ChIP-Seq_THP-1_Human1.43478936
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41104038
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40228165
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39030562
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37583757
49* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37402172
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.37127927
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36962772
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35262697
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.34712211
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31085546
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27721946
56CREB1_26743006_Chip-Seq_LNCaP_Human1.25917000
57MAF_26560356_Chip-Seq_TH1_Human1.23801545
58* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23154908
59* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22773430
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.22755097
61BCL6_27268052_Chip-Seq_Bcells_Human1.22536571
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20710341
63CTCF_27219007_Chip-Seq_Bcells_Human1.19897038
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.19803791
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.18786537
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17865515
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17587426
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15705493
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.14592402
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13354681
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.12565506
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12503101
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12370154
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.11807948
75MAF_26560356_Chip-Seq_TH2_Human1.10917426
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10826998
77NCOR1_26117541_ChIP-Seq_K562_Human1.10041144
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10004363
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08532937
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08522405
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08234231
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.07472089
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07403945
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07285662
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06487449
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06431752
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05980650
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05332580
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04314913
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02389889
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01735992
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01385273
93* TP53_22127205_ChIP-Seq_IMR90_Human1.01312570
94UTX_26944678_Chip-Seq_JUKART_Human1.01210137
95* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00791836
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.99541456
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98906175
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94622936
99HTT_18923047_ChIP-ChIP_STHdh_Human0.94546374
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87158109
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86044402
102GATA4_25053715_ChIP-Seq_YYC3_Human0.85147078
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83424630
104TRIM28_21343339_ChIP-Seq_HEK293_Human0.83071409
105LXR_22292898_ChIP-Seq_THP-1_Human0.82760716
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81672226
107RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79100622
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77939683
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77939683
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77044003
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76569577
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.76211658
113GATA1_19941826_ChIP-Seq_K562_Human0.75157890
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74946339
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73406018
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72995566
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72871371
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71759197
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.71277063
120* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71143632
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.71046004
122CEBPB_22108803_ChIP-Seq_LS180_Human0.70206192
123GATA2_19941826_ChIP-Seq_K562_Human0.68854543
124* RACK7_27058665_Chip-Seq_MCF-7_Human0.68317002
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68219133
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67847945
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64146900
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63529027
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.62861791
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62101944
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60822157
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.60231291
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60045709
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.59618452
135BCAT_22108803_ChIP-Seq_LS180_Human0.59551519
136MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.59245509
137ATF3_27146783_Chip-Seq_COLON_Human0.58033415
138* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57740093
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57273591
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.56873147
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.55627182
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55001088
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54365363
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53620175
145TAF2_19829295_ChIP-Seq_ESCs_Human0.53571629
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53285668
147* BCOR_27268052_Chip-Seq_Bcells_Human0.53138662
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.52946455
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52131866
150CBP_21632823_ChIP-Seq_H3396_Human0.51973180
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51802975
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.51443406
153TP63_22573176_ChIP-Seq_HFKS_Human0.51144384
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.51096698
155ERG_20517297_ChIP-Seq_VCAP_Human0.50713152
156SOX2_20726797_ChIP-Seq_SW620_Human0.50338218
157* EGR1_19032775_ChIP-ChIP_M12_Human0.50140314
158GATA6_25053715_ChIP-Seq_YYC3_Human0.50073196
159AR_20517297_ChIP-Seq_VCAP_Human0.49826375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.89283918
2MP0005360_urolithiasis5.55716601
3MP0005085_abnormal_gallbladder_physiolo4.75288036
4MP0005365_abnormal_bile_salt4.57835001
5MP0002837_dystrophic_cardiac_calcinosis3.89758407
6MP0008875_abnormal_xenobiotic_pharmacok3.55138569
7MP0003806_abnormal_nucleotide_metabolis3.49455330
8MP0005058_abnormal_lysosome_morphology3.16674622
9MP0010329_abnormal_lipoprotein_level3.00401777
10MP0003252_abnormal_bile_duct2.89918917
11MP0003646_muscle_fatigue2.85113361
12MP0004130_abnormal_muscle_cell2.71080736
13MP0009840_abnormal_foam_cell2.64305569
14MP0005670_abnormal_white_adipose2.61372703
15* MP0005332_abnormal_amino_acid2.53404565
16MP0003195_calcinosis2.45104022
17MP0004084_abnormal_cardiac_muscle2.26390310
18MP0005083_abnormal_biliary_tract2.14521014
19MP0000751_myopathy2.12077291
20MP0003191_abnormal_cellular_cholesterol2.07825586
21* MP0002118_abnormal_lipid_homeostasis2.06372899
22* MP0005330_cardiomyopathy1.99252996
23MP0004215_abnormal_myocardial_fiber1.98187356
24MP0001666_abnormal_nutrient_absorption1.93297493
25MP0004036_abnormal_muscle_relaxation1.90329507
26* MP0006036_abnormal_mitochondrial_physio1.85033650
27* MP0000609_abnormal_liver_physiology1.83391448
28MP0004510_myositis1.79172632
29MP0005319_abnormal_enzyme/_coenzyme1.79152567
30* MP0005666_abnormal_adipose_tissue1.74031609
31MP0000749_muscle_degeneration1.71138915
32MP0003566_abnormal_cell_adhesion1.69580837
33MP0004858_abnormal_nervous_system1.67671544
34MP0005409_darkened_coat_color1.64556404
35MP0003436_decreased_susceptibility_to1.56149891
36MP0008260_abnormal_autophagy1.54301351
37* MP0005584_abnormal_enzyme/coenzyme_acti1.53177197
38MP0004019_abnormal_vitamin_homeostasis1.47819169
39* MP0004087_abnormal_muscle_fiber1.47450557
40MP0001849_ear_inflammation1.47271982
41MP0004185_abnormal_adipocyte_glucose1.46949262
42MP0003300_gastrointestinal_ulcer1.46335162
43MP0003705_abnormal_hypodermis_morpholog1.46216380
44MP0003172_abnormal_lysosome_physiology1.46107016
45MP0008775_abnormal_heart_ventricle1.44436975
46* MP0002971_abnormal_brown_adipose1.43922206
47MP0002972_abnormal_cardiac_muscle1.42621588
48MP0001958_emphysema1.40445220
49MP0010234_abnormal_vibrissa_follicle1.40360672
50MP0009643_abnormal_urine_homeostasis1.40228906
51MP0003453_abnormal_keratinocyte_physiol1.40122437
52MP0005451_abnormal_body_composition1.38522788
53MP0001544_abnormal_cardiovascular_syste1.37095809
54MP0005385_cardiovascular_system_phenoty1.37095809
55MP0003279_aneurysm1.36764430
56MP0002269_muscular_atrophy1.32474549
57MP0002138_abnormal_hepatobiliary_system1.30962519
58MP0003303_peritoneal_inflammation1.29688909
59MP0005620_abnormal_muscle_contractility1.28475510
60MP0004947_skin_inflammation1.28290300
61MP0006138_congestive_heart_failure1.27200022
62MP0001764_abnormal_homeostasis1.25441411
63MP0003091_abnormal_cell_migration1.21981071
64MP0005023_abnormal_wound_healing1.17305061
65* MP0010630_abnormal_cardiac_muscle1.17246922
66MP0000858_altered_metastatic_potential1.16671607
67MP0003186_abnormal_redox_activity1.14917358
68MP0002877_abnormal_melanocyte_morpholog1.14408139
69MP0003221_abnormal_cardiomyocyte_apopto1.14366732
70MP0000750_abnormal_muscle_regeneration1.13312824
71MP0005076_abnormal_cell_differentiation1.13132319
72MP0004233_abnormal_muscle_weight1.12387562
73* MP0000003_abnormal_adipose_tissue1.11498711
74MP0010368_abnormal_lymphatic_system1.09776823
75MP0006035_abnormal_mitochondrial_morpho1.09055326
76* MP0002078_abnormal_glucose_homeostasis1.08979767
77MP0003137_abnormal_impulse_conducting1.08927973
78* MP0005375_adipose_tissue_phenotype1.08026445
79MP0000747_muscle_weakness1.07207909
80* MP0005535_abnormal_body_temperature1.05264563
81MP0002796_impaired_skin_barrier1.04978811
82MP0003075_altered_response_to1.04207645
83MP0005334_abnormal_fat_pad1.04081892
84MP0004272_abnormal_basement_membrane1.01860705
85MP0004043_abnormal_pH_regulation1.01428956
86MP0009278_abnormal_bone_marrow1.00787848
87MP0010155_abnormal_intestine_physiology0.99711315
88MP0005166_decreased_susceptibility_to0.98922211
89MP0003868_abnormal_feces_composition0.97916108
90MP0003656_abnormal_erythrocyte_physiolo0.96061895
91MP0002106_abnormal_muscle_physiology0.95440072
92MP0005266_abnormal_metabolism0.95168339
93MP0000733_abnormal_muscle_development0.94388554
94MP0002998_abnormal_bone_remodeling0.94011971
95MP0003011_delayed_dark_adaptation0.93427694
96MP0002332_abnormal_exercise_endurance0.90631357
97MP0000598_abnormal_liver_morphology0.90204455
98MP0001533_abnormal_skeleton_physiology0.88016910
99MP0001661_extended_life_span0.86865858
100MP0002060_abnormal_skin_morphology0.86089800
101MP0008438_abnormal_cutaneous_collagen0.85275796
102MP0001756_abnormal_urination0.84826141
103MP0008004_abnormal_stomach_pH0.84488593
104MP0004484_altered_response_of0.84481547
105MP0000230_abnormal_systemic_arterial0.84467868
106MP0003879_abnormal_hair_cell0.83572157
107MP0000678_abnormal_parathyroid_gland0.82167601
108MP0002896_abnormal_bone_mineralization0.82072572
109MP0009115_abnormal_fat_cell0.81057202
110MP0005397_hematopoietic_system_phenotyp0.80059773
111MP0001545_abnormal_hematopoietic_system0.80059773
112MP0009697_abnormal_copulation0.79359990
113* MP0000759_abnormal_skeletal_muscle0.79207974
114MP0005464_abnormal_platelet_physiology0.79153460
115MP0003183_abnormal_peptide_metabolism0.78483262
116MP0000604_amyloidosis0.77613919
117MP0000249_abnormal_blood_vessel0.77557044
118MP0005636_abnormal_mineral_homeostasis0.77307830
119MP0005376_homeostasis/metabolism_phenot0.76488188
120MP0005025_abnormal_response_to0.76334054
121MP0005501_abnormal_skin_physiology0.75771872
122* MP0009642_abnormal_blood_homeostasis0.75675702
123MP0005369_muscle_phenotype0.75218190
124MP0005448_abnormal_energy_balance0.74758184
125* MP0009763_increased_sensitivity_to0.74308166
126MP0002970_abnormal_white_adipose0.73049885
127* MP0004085_abnormal_heartbeat0.72966227
128MP0000343_altered_response_to0.68759033
129MP0009764_decreased_sensitivity_to0.67848930
130MP0000013_abnormal_adipose_tissue0.67418868
131MP0005165_increased_susceptibility_to0.66749035
132MP0005647_abnormal_sex_gland0.64159740
133MP0008469_abnormal_protein_level0.62987037
134MP0003690_abnormal_glial_cell0.61226368
135MP0003329_amyloid_beta_deposits0.59472155
136MP0003828_pulmonary_edema0.58920004
137MP0004147_increased_porphyrin_level0.58083589
138MP0002254_reproductive_system_inflammat0.57565150
139MP0003950_abnormal_plasma_membrane0.56390141
140MP0005275_abnormal_skin_tensile0.55283665
141MP0009384_cardiac_valve_regurgitation0.54459183
142MP0002127_abnormal_cardiovascular_syste0.54447703
143MP0008961_abnormal_basal_metabolism0.51890020
144MP0003953_abnormal_hormone_level0.50309635

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.10913845
2Hyperglycinuria (HP:0003108)4.78806780
3Hyperammonemia (HP:0001987)4.67151081
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60095413
5Ketosis (HP:0001946)4.58967801
6Deep venous thrombosis (HP:0002625)4.58611295
7Intrahepatic cholestasis (HP:0001406)4.54243620
8Xanthomatosis (HP:0000991)4.53208217
9* Abnormality of fatty-acid metabolism (HP:0004359)4.45558931
10Abnormality of glycine metabolism (HP:0010895)4.34077053
11Abnormality of serine family amino acid metabolism (HP:0010894)4.34077053
12Ketoacidosis (HP:0001993)4.29225739
13Hyperlipoproteinemia (HP:0010980)3.99898401
14Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.92350672
15* Myoglobinuria (HP:0002913)3.87057949
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86926668
17Hyperglycinemia (HP:0002154)3.86634712
18* Dicarboxylic aciduria (HP:0003215)3.81195854
19* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.81195854
20Hypoalphalipoproteinemia (HP:0003233)3.76587333
21Hypobetalipoproteinemia (HP:0003563)3.73419911
22Distal lower limb muscle weakness (HP:0009053)3.63482884
23Prolonged partial thromboplastin time (HP:0003645)3.61241701
24Hypolipoproteinemia (HP:0010981)3.56342266
25Sudden death (HP:0001699)3.48808802
26Generalized aminoaciduria (HP:0002909)3.37432533
27Complement deficiency (HP:0004431)3.34524360
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32584519
29Cerebral edema (HP:0002181)3.28105062
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27242850
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.26697096
32Distal lower limb amyotrophy (HP:0008944)3.24860792
33Type 1 muscle fiber predominance (HP:0003803)3.21902043
34Myopathic facies (HP:0002058)3.14742428
35Epidermoid cyst (HP:0200040)3.13072336
36Systemic lupus erythematosus (HP:0002725)3.12769812
37Ventricular tachycardia (HP:0004756)3.06446900
38* Rhabdomyolysis (HP:0003201)3.05349488
39Protrusio acetabuli (HP:0003179)3.04598165
40Metabolic acidosis (HP:0001942)3.03766139
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02281392
42Exercise-induced muscle cramps (HP:0003710)2.93366516
43Right ventricular cardiomyopathy (HP:0011663)2.92484042
44Hemorrhage of the eye (HP:0011885)2.88943142
45Muscle fiber inclusion bodies (HP:0100299)2.87967240
46Increased muscle lipid content (HP:0009058)2.86943161
47Palpitations (HP:0001962)2.86776323
48Abnormality of serum amino acid levels (HP:0003112)2.85438059
49* Lethargy (HP:0001254)2.84926642
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.81804580
51Increased variability in muscle fiber diameter (HP:0003557)2.79870194
52* Hepatic necrosis (HP:0002605)2.79490471
53Abnormality of skeletal muscle fiber size (HP:0012084)2.78839102
54Vertebral compression fractures (HP:0002953)2.73406642
55Proximal tubulopathy (HP:0000114)2.72452650
56Mildly elevated creatine phosphokinase (HP:0008180)2.69971208
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.69718890
58Abnormality of the common coagulation pathway (HP:0010990)2.69335416
59Nemaline bodies (HP:0003798)2.68256502
60Abnormality of methionine metabolism (HP:0010901)2.63801962
61Calf muscle hypertrophy (HP:0008981)2.61855014
62Thin bony cortex (HP:0002753)2.61847615
63Hyporeflexia of lower limbs (HP:0002600)2.60561850
64Joint hemorrhage (HP:0005261)2.60486409
65Nausea (HP:0002018)2.58532804
66Dysostosis multiplex (HP:0000943)2.56450564
67Acute encephalopathy (HP:0006846)2.55290665
68Lipoatrophy (HP:0100578)2.55125166
69Urinary glycosaminoglycan excretion (HP:0003541)2.53262595
70Mucopolysacchariduria (HP:0008155)2.53262595
71Muscle fiber splitting (HP:0003555)2.52937217
72Skin nodule (HP:0200036)2.52607381
73Renal cortical cysts (HP:0000803)2.51584454
74Cerebral aneurysm (HP:0004944)2.50038859
75Gout (HP:0001997)2.48695517
76Abnormality of purine metabolism (HP:0004352)2.45702043
77Hypercholesterolemia (HP:0003124)2.45549155
78* Vomiting (HP:0002013)2.44988893
79Hyperinsulinemic hypoglycemia (HP:0000825)2.44868405
80Abnormality of polysaccharide metabolism (HP:0011012)2.44116808
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44116808
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44116808
83Fat malabsorption (HP:0002630)2.41908282
84Premature rupture of membranes (HP:0001788)2.40993664
85Abnormality of the intrinsic pathway (HP:0010989)2.39525879
86Dilated cardiomyopathy (HP:0001644)2.39505793
87Cervical subluxation (HP:0003308)2.38960733
88Hyperbilirubinemia (HP:0002904)2.38238933
89Cholelithiasis (HP:0001081)2.37888328
90Muscle hypertrophy of the lower extremities (HP:0008968)2.37681068
91EMG: myopathic abnormalities (HP:0003458)2.37365226
92Atrioventricular block (HP:0001678)2.35749814
93Delayed CNS myelination (HP:0002188)2.33643065
94Abnormality of complement system (HP:0005339)2.32727000
95Hypoglycemic seizures (HP:0002173)2.32422324
96Abnormal gallbladder morphology (HP:0012437)2.31277551
97Difficulty climbing stairs (HP:0003551)2.30871615
98Increased connective tissue (HP:0009025)2.29794615
99Bundle branch block (HP:0011710)2.26457431
100Achilles tendon contracture (HP:0001771)2.24828201
101Hydroxyprolinuria (HP:0003080)2.24444536
102Abnormality of proline metabolism (HP:0010907)2.24444536
103Abnormality of the Achilles tendon (HP:0005109)2.23189878
104Conjunctival hamartoma (HP:0100780)2.22471984
105Neck muscle weakness (HP:0000467)2.22306284
106Asymmetric septal hypertrophy (HP:0001670)2.22014680
107Abnormality of liposaccharide metabolism (HP:0010968)2.21801550
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.21801550
109Abnormality of glycolipid metabolism (HP:0010969)2.21801550
110Atrial fibrillation (HP:0005110)2.21261219
111Lactic acidosis (HP:0003128)2.20059377
112Abnormality of nucleobase metabolism (HP:0010932)2.19818686
113Hyperglycemia (HP:0003074)2.15995535
114Flat acetabular roof (HP:0003180)2.15389048
115* Exercise-induced myalgia (HP:0003738)2.15254105
116Increased serum pyruvate (HP:0003542)2.15211671
117Abnormality of glycolysis (HP:0004366)2.15211671
118J-shaped sella turcica (HP:0002680)2.13106097
119Abnormal mitochondria in muscle tissue (HP:0008316)2.11180319
120Hyperuricemia (HP:0002149)2.10554337
121Increased purine levels (HP:0004368)2.10554337
122Ragged-red muscle fibers (HP:0003200)2.10101975
123Late onset (HP:0003584)2.10008538
124Malnutrition (HP:0004395)2.08412263
125Abnormality of urine glucose concentration (HP:0011016)2.08388600
126Glycosuria (HP:0003076)2.08388600
127Distal upper limb amyotrophy (HP:0007149)2.07950844
128Upper limb amyotrophy (HP:0009129)2.07950844
129Broad face (HP:0000283)2.07582497
130Increased intramyocellular lipid droplets (HP:0012240)2.06611871
131Syncope (HP:0001279)2.06597609
132Spinal rigidity (HP:0003306)2.06312518
133Heart block (HP:0012722)2.05709697
134Ulnar deviation of the wrist (HP:0003049)2.05201616
135Round ear (HP:0100830)2.04617732
136Glomerulonephritis (HP:0000099)2.04386692
137Bulbar palsy (HP:0001283)2.03509903
138Joint stiffness (HP:0001387)2.02787384
139Difficulty running (HP:0009046)2.02403491
140Lower limb amyotrophy (HP:0007210)2.02396022
141Abnormality of the calf musculature (HP:0001430)2.02006045
142Myocardial infarction (HP:0001658)2.01459474
143Nuclear cataract (HP:0100018)2.01059934
144Primary atrial arrhythmia (HP:0001692)1.99388292
145Stridor (HP:0010307)1.98036525
146Methylmalonic aciduria (HP:0012120)1.97820272
147Axonal loss (HP:0003447)1.96139784
148Hypertriglyceridemia (HP:0002155)1.96000555
149Foot dorsiflexor weakness (HP:0009027)1.95937635
150Aneurysm (HP:0002617)1.94414988
151Abnormal atrioventricular conduction (HP:0005150)1.94079972
152Hepatocellular carcinoma (HP:0001402)1.93958806
153Ulnar bowing (HP:0003031)1.91515198
154Eczematoid dermatitis (HP:0000976)1.86031988
155Hyperacusis (HP:0010780)1.85341402
156Abnormality of the foot musculature (HP:0001436)1.82332462
157Fragile skin (HP:0001030)1.78941007
158Scapular winging (HP:0003691)1.78046282
159Interstitial pulmonary disease (HP:0006530)1.77955014
160Back pain (HP:0003418)1.77310585
161Amyloidosis (HP:0011034)1.74808574
162Neurofibrillary tangles (HP:0002185)1.74620044
163Colitis (HP:0002583)1.71622632
164Atrophic scars (HP:0001075)1.70276418
165Ventricular arrhythmia (HP:0004308)1.68702209
166Biconcave vertebral bodies (HP:0004586)1.67282188
167Reticulocytosis (HP:0001923)1.66155550
168EMG: neuropathic changes (HP:0003445)1.65576401
169Cerebral inclusion bodies (HP:0100314)1.64311146
170Polycythemia (HP:0001901)1.62700090
171Nephritis (HP:0000123)1.62339700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.28067619
2TRIB33.68254789
3TTN3.57963093
4PDK33.56470880
5PDK43.56470880
6PKN23.04911203
7SIK12.86174857
8OBSCN2.53319256
9LMTK22.52222100
10PRPF4B2.45931224
11ERN12.44621169
12FGFR42.40695145
13PHKG22.20892466
14PHKG12.20892466
15PDK22.20073670
16MYLK2.16360928
17INSRR2.14778056
18TIE11.89157554
19IRAK31.88286757
20EEF2K1.81673055
21PINK11.80853850
22SMG11.78512126
23EPHA21.68793714
24NEK11.60188330
25CDC42BPA1.58144252
26FLT31.55939098
27PIK3CA1.50384578
28TESK11.43643107
29PRKAA21.36179721
30CAMK1D1.34094372
31MAP3K131.32153957
32ZAP701.29954303
33MAP3K61.28370955
34MAP2K31.21162447
35WNK41.20441495
36NEK91.15984343
37MAP3K71.15776988
38PIK3CG1.15407895
39DDR21.13387844
40RIPK11.13039261
41STK38L1.12363559
42MST1R1.11723154
43TAOK21.11506099
44MAP3K11.07895011
45NME21.07225017
46EPHB11.03422908
47KDR1.03388439
48MAP3K31.01928790
49PRKAA10.99162886
50MAPK110.98936421
51PTK60.98850049
52NTRK10.96909156
53PTK20.96466759
54LATS10.96450386
55PRKD20.95265731
56TGFBR20.93287057
57CDK120.92794003
58MAPK120.91473619
59PAK30.91082418
60DMPK0.90090295
61PIM20.89954416
62TESK20.89034326
63MAP2K40.88028407
64STK240.86634164
65PRKD10.84237300
66ARAF0.83495093
67KSR20.83173509
68ERBB40.82056768
69SCYL20.80427169
70MARK20.79307064
71RPS6KA20.77672788
72PDGFRA0.77208081
73PDPK10.76437660
74PAK40.75621760
75BLK0.73599390
76JAK30.73275260
77JAK10.71971886
78TYK20.71898902
79MAP3K140.70905240
80CAMK1G0.70859675
81TAOK10.70630998
82MAP4K10.69969363
83TAOK30.68339166
84PRKACG0.66943964
85JAK20.65514868
86LATS20.64745036
87MOS0.64420084
88FRK0.62983951
89MAPK150.62119910
90RPS6KL10.61392612
91RPS6KC10.61392612
92TBK10.59488173
93GRK70.59381881
94CAMK2D0.59300735
95DYRK1B0.59017674
96ABL20.58944567
97BMX0.58572200
98EPHA30.56946529
99RIPK40.55774491
100MAP2K20.55284363
101FGFR20.54810641
102PDK10.54657242
103ILK0.53595318
104CAMK2G0.53488353
105MAP3K50.52868272
106MAP2K10.52692293
107PRKD30.52262383
108MAPKAPK30.50927170
109MUSK0.50198832
110MET0.49993417
111SGK30.48122957
112PDGFRB0.45867857
113FGFR30.45499027
114PKN10.44837124
115ROCK10.44691290
116MAP3K110.43273388
117RET0.40864549
118MAPK40.40661175
119HIPK20.40651054
120RPS6KA60.40646046
121ICK0.40200984
122PRKCH0.38770539
123GSK3A0.38531464
124CAMK40.38107160
125LRRK20.35948532
126TRPM70.34914249
127STK390.34763964
128MAP2K60.34699149
129MTOR0.34676690
130DAPK30.33673891
131FER0.33265692
132PRKACB0.31150942
133PRKACA0.29803482
134STK380.29654387
135MAP3K100.28464689
136MAPK70.25541026
137PRKCZ0.25409222
138SGK4940.24401173
139SGK2230.24401173
140STK40.24005686
141IGF1R0.23312496
142PRKG20.22813256
143CDK60.21398911
144PRKCQ0.21199594

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.44943033
2Propanoate metabolism_Homo sapiens_hsa006403.44146429
3* Fatty acid degradation_Homo sapiens_hsa000713.43363328
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.33570491
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.30121289
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21419343
7Primary bile acid biosynthesis_Homo sapiens_hsa001203.12697809
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.09350586
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93191550
10* Fatty acid metabolism_Homo sapiens_hsa012122.68646190
11Nitrogen metabolism_Homo sapiens_hsa009102.61794279
12Tryptophan metabolism_Homo sapiens_hsa003802.48221098
13Butanoate metabolism_Homo sapiens_hsa006502.46422693
14Arginine biosynthesis_Homo sapiens_hsa002202.42179614
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36673790
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33954048
17PPAR signaling pathway_Homo sapiens_hsa033202.33566012
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.22033002
19Pyruvate metabolism_Homo sapiens_hsa006202.10991199
20Carbon metabolism_Homo sapiens_hsa012002.07748966
21Peroxisome_Homo sapiens_hsa041462.02777024
22Fatty acid elongation_Homo sapiens_hsa000621.93147337
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87174991
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86960085
25beta-Alanine metabolism_Homo sapiens_hsa004101.84295804
26Complement and coagulation cascades_Homo sapiens_hsa046101.75662648
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65466751
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49353357
29Biosynthesis of amino acids_Homo sapiens_hsa012301.37852952
30Phenylalanine metabolism_Homo sapiens_hsa003601.35599730
31Caffeine metabolism_Homo sapiens_hsa002321.35113550
32Starch and sucrose metabolism_Homo sapiens_hsa005001.34989265
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33628515
34Chemical carcinogenesis_Homo sapiens_hsa052041.30216371
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29147018
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28747337
37Histidine metabolism_Homo sapiens_hsa003401.27949392
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19895225
39Sulfur metabolism_Homo sapiens_hsa009201.17805929
40Bile secretion_Homo sapiens_hsa049761.17604485
41Fat digestion and absorption_Homo sapiens_hsa049751.16932686
42Lysosome_Homo sapiens_hsa041421.16725700
43Tyrosine metabolism_Homo sapiens_hsa003501.15819594
44Fatty acid biosynthesis_Homo sapiens_hsa000611.13079594
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.10865122
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.08713239
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08601924
48Retinol metabolism_Homo sapiens_hsa008301.08578797
49Selenocompound metabolism_Homo sapiens_hsa004501.05466740
50VEGF signaling pathway_Homo sapiens_hsa043701.01545208
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.99838475
52Staphylococcus aureus infection_Homo sapiens_hsa051500.99740890
53Renin-angiotensin system_Homo sapiens_hsa046140.98423737
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95220483
55Lysine degradation_Homo sapiens_hsa003100.94642766
56Arginine and proline metabolism_Homo sapiens_hsa003300.93882768
57ABC transporters_Homo sapiens_hsa020100.91817974
58Glycerolipid metabolism_Homo sapiens_hsa005610.91815423
59Acute myeloid leukemia_Homo sapiens_hsa052210.91389043
60Pertussis_Homo sapiens_hsa051330.89045516
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81337002
62Focal adhesion_Homo sapiens_hsa045100.81160575
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79128447
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78979286
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78830820
66Bladder cancer_Homo sapiens_hsa052190.78115889
67ECM-receptor interaction_Homo sapiens_hsa045120.77683190
68Oxidative phosphorylation_Homo sapiens_hsa001900.77662604
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77128276
70Folate biosynthesis_Homo sapiens_hsa007900.76886707
71Parkinsons disease_Homo sapiens_hsa050120.74142214
72Hepatitis C_Homo sapiens_hsa051600.73234013
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.72978282
74Notch signaling pathway_Homo sapiens_hsa043300.72334388
75GnRH signaling pathway_Homo sapiens_hsa049120.71118441
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70965837
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.70788727
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68126118
79Cardiac muscle contraction_Homo sapiens_hsa042600.66804640
80Pentose phosphate pathway_Homo sapiens_hsa000300.65352769
81Sulfur relay system_Homo sapiens_hsa041220.64900044
82Insulin resistance_Homo sapiens_hsa049310.63144830
83Toxoplasmosis_Homo sapiens_hsa051450.63089606
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62916207
85Osteoclast differentiation_Homo sapiens_hsa043800.59541410
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59345300
87Leishmaniasis_Homo sapiens_hsa051400.57630419
88Glutathione metabolism_Homo sapiens_hsa004800.57559500
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.57445284
90Vitamin digestion and absorption_Homo sapiens_hsa049770.56266903
91Vitamin B6 metabolism_Homo sapiens_hsa007500.55407036
92TNF signaling pathway_Homo sapiens_hsa046680.54128235
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53272963
94* Metabolic pathways_Homo sapiens_hsa011000.51066664
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.50251870
96Mineral absorption_Homo sapiens_hsa049780.49054915
97Alzheimers disease_Homo sapiens_hsa050100.48744463
98Steroid biosynthesis_Homo sapiens_hsa001000.48154751
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48094859
100Non-small cell lung cancer_Homo sapiens_hsa052230.47747453
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47730331
102Fructose and mannose metabolism_Homo sapiens_hsa000510.47638450
103Galactose metabolism_Homo sapiens_hsa000520.46926999
104Glucagon signaling pathway_Homo sapiens_hsa049220.46525256
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.46461476
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46010255
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45623561
108Pancreatic cancer_Homo sapiens_hsa052120.44910976
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44359015
110Dilated cardiomyopathy_Homo sapiens_hsa054140.44072283
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43903483
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43467545
113AMPK signaling pathway_Homo sapiens_hsa041520.42335200
114Salmonella infection_Homo sapiens_hsa051320.41175645
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39688101
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39413187
117Insulin signaling pathway_Homo sapiens_hsa049100.29728776
118Huntingtons disease_Homo sapiens_hsa050160.26108619
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.22113639
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20937655
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18253965
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15329319
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11090415
124Linoleic acid metabolism_Homo sapiens_hsa005910.09383872
125Prion diseases_Homo sapiens_hsa050200.07361078
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.06666335
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04829239
128One carbon pool by folate_Homo sapiens_hsa006700.03769543
129Amoebiasis_Homo sapiens_hsa05146-0.1256562
130Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1231755
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.1199899
132Protein digestion and absorption_Homo sapiens_hsa04974-0.1053562
133Type II diabetes mellitus_Homo sapiens_hsa04930-0.0942034
134Viral myocarditis_Homo sapiens_hsa05416-0.0641190
135Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0598074
136Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0293289

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