ACADL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.20557988
2drug catabolic process (GO:0042737)6.71000829
3tricarboxylic acid cycle (GO:0006099)6.34348975
4carnitine shuttle (GO:0006853)5.84377276
5lysine catabolic process (GO:0006554)5.78239791
6lysine metabolic process (GO:0006553)5.78239791
7fatty acid transmembrane transport (GO:1902001)5.68020066
8* fatty acid beta-oxidation (GO:0006635)5.40196819
9regulation of sequestering of triglyceride (GO:0010889)5.28189786
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.12253821
112-oxoglutarate metabolic process (GO:0006103)5.11039420
12omega-hydroxylase P450 pathway (GO:0097267)5.10040899
13oxidative demethylation (GO:0070989)5.08382928
14epoxygenase P450 pathway (GO:0019373)5.05606653
15NADH metabolic process (GO:0006734)4.80126160
16* fatty acid oxidation (GO:0019395)4.77077020
17* lipid oxidation (GO:0034440)4.68998913
18* fatty acid catabolic process (GO:0009062)4.68248129
19carnitine transmembrane transport (GO:1902603)4.58813201
20valine metabolic process (GO:0006573)4.57122428
21aspartate family amino acid catabolic process (GO:0009068)4.54831997
22branched-chain amino acid catabolic process (GO:0009083)4.52432446
23acetyl-CoA metabolic process (GO:0006084)4.52254285
24regulation of acyl-CoA biosynthetic process (GO:0050812)4.51964442
25carnitine transport (GO:0015879)4.46041215
26amino-acid betaine transport (GO:0015838)4.46041215
27glyoxylate metabolic process (GO:0046487)4.45635693
28tricarboxylic acid metabolic process (GO:0072350)4.41224508
29drug metabolic process (GO:0017144)4.40026042
30biotin metabolic process (GO:0006768)4.38302220
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36693791
32short-chain fatty acid metabolic process (GO:0046459)4.35526369
33cellular glucuronidation (GO:0052695)4.35236507
34sarcomere organization (GO:0045214)4.29776719
35cellular ketone body metabolic process (GO:0046950)4.26556145
36branched-chain amino acid metabolic process (GO:0009081)4.24014789
37regulation of triglyceride catabolic process (GO:0010896)4.23766897
38succinate metabolic process (GO:0006105)4.18302229
39* regulation of fatty acid oxidation (GO:0046320)4.16591684
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.15061150
41regulation of cofactor metabolic process (GO:0051193)4.13893290
42regulation of coenzyme metabolic process (GO:0051196)4.13893290
43* monocarboxylic acid catabolic process (GO:0072329)4.13086468
44alpha-linolenic acid metabolic process (GO:0036109)4.09286495
45regulation of protein activation cascade (GO:2000257)4.07790897
46uronic acid metabolic process (GO:0006063)4.04349423
47glucuronate metabolic process (GO:0019585)4.04349423
48positive regulation of fatty acid oxidation (GO:0046321)4.03538571
49L-phenylalanine metabolic process (GO:0006558)4.00191985
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00191985
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.96587255
52negative regulation of protein activation cascade (GO:2000258)3.91656606
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.90031899
54L-phenylalanine catabolic process (GO:0006559)3.90031899
55regulation of complement activation (GO:0030449)3.88398571
56* amino-acid betaine metabolic process (GO:0006577)3.85414054
57negative regulation of complement activation (GO:0045916)3.83898281
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79965535
59cardiac myofibril assembly (GO:0055003)3.75541054
60oxidative phosphorylation (GO:0006119)3.74341787
61kynurenine metabolic process (GO:0070189)3.73808065
62quaternary ammonium group transport (GO:0015697)3.69887526
63S-adenosylmethionine metabolic process (GO:0046500)3.67704952
64* carnitine metabolic process (GO:0009437)3.67633358
65bile acid metabolic process (GO:0008206)3.67219214
66ketone body metabolic process (GO:1902224)3.66485037
67regulation of fibrinolysis (GO:0051917)3.66184741
68oxaloacetate metabolic process (GO:0006107)3.64237137
69bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62391729
70regulation of sulfur metabolic process (GO:0042762)3.59677200
71ethanol oxidation (GO:0006069)3.56387493
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.52987258
73amine catabolic process (GO:0009310)3.50837384
74cellular biogenic amine catabolic process (GO:0042402)3.50837384
75negative regulation of fibrinolysis (GO:0051918)3.50661852
76cysteine metabolic process (GO:0006534)3.50647545
77aromatic amino acid family catabolic process (GO:0009074)3.49923210
78flavonoid metabolic process (GO:0009812)3.49903168
79sulfur amino acid catabolic process (GO:0000098)3.49435995
80complement activation, alternative pathway (GO:0006957)3.47472482
81respiratory electron transport chain (GO:0022904)3.45358238
82muscle filament sliding (GO:0030049)3.44133144
83actin-myosin filament sliding (GO:0033275)3.44133144
84glycine metabolic process (GO:0006544)3.43325964
85drug transmembrane transport (GO:0006855)3.43163331
86regulation of fatty acid beta-oxidation (GO:0031998)3.37732319
87alkaloid metabolic process (GO:0009820)3.37663538
88* carboxylic acid catabolic process (GO:0046395)3.36046647
89* organic acid catabolic process (GO:0016054)3.36046647
90electron transport chain (GO:0022900)3.35354288
91myofibril assembly (GO:0030239)3.34924937
92ethanol metabolic process (GO:0006067)3.33254109
93positive regulation of lipid catabolic process (GO:0050996)3.32518430
94serine family amino acid catabolic process (GO:0009071)3.26442362
95indolalkylamine metabolic process (GO:0006586)3.24205338
96blood coagulation, intrinsic pathway (GO:0007597)3.23676293
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22448997
98tryptophan catabolic process (GO:0006569)3.19296908
99indole-containing compound catabolic process (GO:0042436)3.19296908
100indolalkylamine catabolic process (GO:0046218)3.19296908
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18767628
102alpha-amino acid catabolic process (GO:1901606)3.17688900
103intracellular lipid transport (GO:0032365)3.15361213
104phenylpropanoid metabolic process (GO:0009698)3.14032910
105arginine metabolic process (GO:0006525)3.13550307
106L-methionine salvage (GO:0071267)3.12931679
107L-methionine biosynthetic process (GO:0071265)3.12931679
108amino acid salvage (GO:0043102)3.12931679
109thioester metabolic process (GO:0035383)3.11538622
110acyl-CoA metabolic process (GO:0006637)3.11538622
111aromatic amino acid family metabolic process (GO:0009072)3.09311357
112bile acid and bile salt transport (GO:0015721)3.09279055
113homocysteine metabolic process (GO:0050667)3.09028800
114thioester biosynthetic process (GO:0035384)3.08939934
115acyl-CoA biosynthetic process (GO:0071616)3.08939934
116benzene-containing compound metabolic process (GO:0042537)3.08730252
117cellular amino acid catabolic process (GO:0009063)3.07512790
118intestinal cholesterol absorption (GO:0030299)3.07416069
119bile acid biosynthetic process (GO:0006699)3.07318954
120arginine catabolic process (GO:0006527)3.07013451
121positive regulation of triglyceride metabolic process (GO:0090208)3.06430655
122fibrinolysis (GO:0042730)3.05940361
123plasma lipoprotein particle clearance (GO:0034381)3.04439441
124phospholipid homeostasis (GO:0055091)3.03960484
125tryptophan metabolic process (GO:0006568)3.01401042
126cardiac muscle cell development (GO:0055013)3.01286611
127positive regulation of lipid storage (GO:0010884)2.99676923
128cardiac muscle contraction (GO:0060048)2.99491423
129triglyceride homeostasis (GO:0070328)2.97116803
130acylglycerol homeostasis (GO:0055090)2.97116803
131organic cation transport (GO:0015695)2.96697920
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95135154
133response to mercury ion (GO:0046689)2.94182857
134energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92469407
135ATP synthesis coupled proton transport (GO:0015986)2.92469407
136positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91913534
137regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91761734
138retinal metabolic process (GO:0042574)2.91269515
139fatty acid homeostasis (GO:0055089)2.91210347
140negative regulation of cholesterol transport (GO:0032375)2.90708765
141negative regulation of sterol transport (GO:0032372)2.90708765
142regulation of relaxation of muscle (GO:1901077)2.90554752
143ventricular cardiac muscle cell action potential (GO:0086005)2.90365603
144regulation of triglyceride biosynthetic process (GO:0010866)2.85085623
145xenobiotic metabolic process (GO:0006805)2.84237015
146dopamine transport (GO:0015872)2.81071688
147response to nitrosative stress (GO:0051409)2.80451241
148chemical homeostasis within a tissue (GO:0048875)2.78178569
149serine family amino acid metabolic process (GO:0009069)2.77018893
150negative regulation of humoral immune response (GO:0002921)2.73009825
151protein K11-linked deubiquitination (GO:0035871)2.71177230
152primary alcohol metabolic process (GO:0034308)2.70242628
153regulation of hexokinase activity (GO:1903299)2.63438362
154regulation of glucokinase activity (GO:0033131)2.63438362
155methionine biosynthetic process (GO:0009086)2.62926428
156drug transport (GO:0015893)2.62506759
157regulation of triglyceride metabolic process (GO:0090207)2.62141631
158peptidyl-glutamic acid carboxylation (GO:0017187)2.61844507
159protein carboxylation (GO:0018214)2.61844507
160sodium-independent organic anion transport (GO:0043252)2.60930981
161negative regulation of blood coagulation (GO:0030195)2.58658907
162negative regulation of hemostasis (GO:1900047)2.58658907
163detection of light stimulus involved in visual perception (GO:0050908)2.55546452
164detection of light stimulus involved in sensory perception (GO:0050962)2.55546452
165positive regulation of glycolytic process (GO:0045821)2.55179756
166regulation of acrosome reaction (GO:0060046)2.55128966
167coenzyme catabolic process (GO:0009109)2.54865019
168protein activation cascade (GO:0072376)2.54844810
169negative regulation of lipase activity (GO:0060192)2.52865038
170tyrosine metabolic process (GO:0006570)2.51813823
171regulation of hippo signaling (GO:0035330)2.51742770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.91819407
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.06218102
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.49824642
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.12077653
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.65952969
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.29761825
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.38156561
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.36477638
9GBX2_23144817_ChIP-Seq_PC3_Human3.12755688
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.94281015
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.84898269
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74897502
13VDR_22108803_ChIP-Seq_LS180_Human2.64958420
14CLOCK_20551151_ChIP-Seq_293T_Human2.56952674
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43013721
16ZNF263_19887448_ChIP-Seq_K562_Human2.41690714
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36087198
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29281700
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28157478
20* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21896406
21EZH2_22144423_ChIP-Seq_EOC_Human2.16968768
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10584756
23GATA1_22025678_ChIP-Seq_K562_Human2.09757795
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.09696749
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08208061
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01936887
27IGF1R_20145208_ChIP-Seq_DFB_Human1.90951893
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90504137
29ZNF274_21170338_ChIP-Seq_K562_Hela1.88185880
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.87054184
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.87054184
32TAF15_26573619_Chip-Seq_HEK293_Human1.83670257
33ER_23166858_ChIP-Seq_MCF-7_Human1.83478195
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82154128
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.75871687
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74985861
37* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69278039
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69144992
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66096920
40P300_19829295_ChIP-Seq_ESCs_Human1.65390012
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.62334651
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61396002
43SMAD4_21799915_ChIP-Seq_A2780_Human1.58795472
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58715628
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55921274
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54231189
47STAT3_23295773_ChIP-Seq_U87_Human1.48648983
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47183222
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46767551
50BCAT_22108803_ChIP-Seq_LS180_Human1.46127834
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45747513
52CBP_20019798_ChIP-Seq_JUKART_Human1.45747513
53FUS_26573619_Chip-Seq_HEK293_Human1.45083404
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44810886
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43989606
56TCF4_23295773_ChIP-Seq_U87_Human1.43422526
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43421578
58AR_25329375_ChIP-Seq_VCAP_Human1.43103264
59* FLI1_27457419_Chip-Seq_LIVER_Mouse1.43047579
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42943737
61AR_21572438_ChIP-Seq_LNCaP_Human1.40072198
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38892810
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37763216
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37686349
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.36712352
66* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35676594
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.35049029
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34919914
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32242643
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31842431
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30925672
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30304213
73* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29271866
74* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28426384
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26680522
76* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26449340
77* CDX2_22108803_ChIP-Seq_LS180_Human1.26144823
78TCF4_22108803_ChIP-Seq_LS180_Human1.25318287
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24427629
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24249382
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23807029
82* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23293585
83EWS_26573619_Chip-Seq_HEK293_Human1.23271592
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22684412
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.21482452
86RUNX2_22187159_ChIP-Seq_PCA_Human1.21472159
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.21301773
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20817010
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19843218
90CJUN_26792858_Chip-Seq_BT549_Human1.19842273
91* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19473537
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.18234364
93* NFE2_27457419_Chip-Seq_LIVER_Mouse1.17975788
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17857512
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.17776860
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17190621
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16342746
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16342746
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16154338
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15760261
101AHR_22903824_ChIP-Seq_MCF-7_Human1.15656466
102DROSHA_22980978_ChIP-Seq_HELA_Human1.14892311
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.14103164
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.13575745
105IRF1_19129219_ChIP-ChIP_H3396_Human1.12582749
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12225725
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.11353071
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11351602
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11191161
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10539671
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10329239
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09930099
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09374946
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.08182646
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07832427
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07629391
117* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07453123
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07215152
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07211861
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07211861
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.06614188
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.06450538
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.06078504
124* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05572616
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05003712
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04700186
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04371669
128TBL1_22424771_ChIP-Seq_293T_Human1.04264292
129* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04035233
130SOX2_19829295_ChIP-Seq_ESCs_Human1.03622965
131NANOG_19829295_ChIP-Seq_ESCs_Human1.03622965
132KDM2B_26808549_Chip-Seq_REH_Human1.03441432
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03372415
134PHF8_20622853_ChIP-Seq_HELA_Human1.03077449
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02517893
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01292167
137FOXA2_19822575_ChIP-Seq_HepG2_Human1.00704266
138ATF3_27146783_Chip-Seq_COLON_Human0.99316035
139GATA4_25053715_ChIP-Seq_YYC3_Human0.97149102
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96718616
141RACK7_27058665_Chip-Seq_MCF-7_Human0.96583771
142* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92448008
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91468597
144GATA1_19941826_ChIP-Seq_K562_Human0.90175699
145ELK3_25401928_ChIP-Seq_HUVEC_Human0.89907149
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89805422
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.87445975
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86521669
149EGR1_19032775_ChIP-ChIP_M12_Human0.85524540
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84563392
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.83227211
152LXR_22292898_ChIP-Seq_THP-1_Human0.83066543
153GATA2_19941826_ChIP-Seq_K562_Human0.81052461
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81050141
155BP1_19119308_ChIP-ChIP_Hs578T_Human0.79975186
156SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79641762
157* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77367824
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76751883
159GATA2_21666600_ChIP-Seq_HMVEC_Human0.76279489
160* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76110444
161BCOR_27268052_Chip-Seq_Bcells_Human0.75475422
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.75255924
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.74547088
164AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73771435
165MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72137046
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70749536
167RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70737222
168BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70208749
169ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69818724
170SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69419940
171GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69135516
172BCL6_27268052_Chip-Seq_Bcells_Human0.69128363
173GATA6_25053715_ChIP-Seq_YYC3_Human0.68708271
174CEBPB_22108803_ChIP-Seq_LS180_Human0.68283537
175CTCF_21964334_Chip-Seq_Bcells_Human0.67806886
176* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67620339
177RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67280227
178ESR1_21235772_ChIP-Seq_MCF-7_Human0.67031257
179AR_21909140_ChIP-Seq_LNCAP_Human0.66562330
180FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66542606
181HIF1A_21447827_ChIP-Seq_MCF-7_Human0.66061032
182* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65759761
183SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.65660801
184GATA3_24758297_ChIP-Seq_MCF-7_Human0.65586181
185SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64688874
186SPI1_20517297_ChIP-Seq_HL60_Human0.64226105
187CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63601735
188BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63561058
189MAF_26560356_Chip-Seq_TH1_Human0.62160284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.05599542
2MP0002837_dystrophic_cardiac_calcinosis4.05143215
3MP0005360_urolithiasis3.95074557
4MP0003646_muscle_fatigue3.85208581
5MP0004084_abnormal_cardiac_muscle3.48251298
6MP0005365_abnormal_bile_salt3.14961375
7MP0002876_abnormal_thyroid_physiology3.04973079
8* MP0005085_abnormal_gallbladder_physiolo3.01988031
9MP0004130_abnormal_muscle_cell3.01033863
10MP0005330_cardiomyopathy2.91020721
11MP0003806_abnormal_nucleotide_metabolis2.89103343
12MP0004215_abnormal_myocardial_fiber2.84189837
13MP0000751_myopathy2.71206994
14MP0003011_delayed_dark_adaptation2.68952697
15MP0004036_abnormal_muscle_relaxation2.61524305
16MP0005670_abnormal_white_adipose2.49955610
17MP0006036_abnormal_mitochondrial_physio2.43800039
18MP0008875_abnormal_xenobiotic_pharmacok2.43287620
19MP0000749_muscle_degeneration2.35274597
20MP0009840_abnormal_foam_cell2.31850593
21MP0003868_abnormal_feces_composition2.28310476
22MP0010329_abnormal_lipoprotein_level2.26073072
23MP0005666_abnormal_adipose_tissue2.23794336
24* MP0005332_abnormal_amino_acid2.17059667
25MP0008775_abnormal_heart_ventricle2.11069728
26MP0004087_abnormal_muscle_fiber2.08645558
27MP0003136_yellow_coat_color2.00951405
28MP0002972_abnormal_cardiac_muscle2.00710166
29MP0003252_abnormal_bile_duct1.98585278
30MP0005385_cardiovascular_system_phenoty1.91806268
31MP0001544_abnormal_cardiovascular_syste1.91806268
32MP0004782_abnormal_surfactant_physiolog1.89252126
33MP0003195_calcinosis1.88233414
34MP0010630_abnormal_cardiac_muscle1.82611831
35MP0003191_abnormal_cellular_cholesterol1.76093167
36MP0000750_abnormal_muscle_regeneration1.71979227
37* MP0002118_abnormal_lipid_homeostasis1.68918696
38MP0005319_abnormal_enzyme/_coenzyme1.68711299
39MP0005620_abnormal_muscle_contractility1.68663792
40MP0006138_congestive_heart_failure1.64588734
41MP0003221_abnormal_cardiomyocyte_apopto1.64582549
42MP0002971_abnormal_brown_adipose1.63208729
43MP0005551_abnormal_eye_electrophysiolog1.56417929
44MP0005083_abnormal_biliary_tract1.56016102
45MP0004185_abnormal_adipocyte_glucose1.55141671
46MP0002269_muscular_atrophy1.52092529
47MP0003137_abnormal_impulse_conducting1.51343985
48MP0005167_abnormal_blood-brain_barrier1.51088429
49* MP0000609_abnormal_liver_physiology1.50970621
50MP0003828_pulmonary_edema1.48947992
51MP0002106_abnormal_muscle_physiology1.47912444
52MP0003879_abnormal_hair_cell1.43531241
53MP0004484_altered_response_of1.42531093
54MP0003186_abnormal_redox_activity1.41435724
55MP0001501_abnormal_sleep_pattern1.41189625
56MP0001666_abnormal_nutrient_absorption1.39275082
57* MP0005584_abnormal_enzyme/coenzyme_acti1.36850799
58MP0001986_abnormal_taste_sensitivity1.34288548
59* MP0009643_abnormal_urine_homeostasis1.34246375
60MP0005451_abnormal_body_composition1.33354041
61MP0009780_abnormal_chondrocyte_physiolo1.33309728
62MP0005646_abnormal_pituitary_gland1.31939275
63MP0000747_muscle_weakness1.31275108
64MP0005375_adipose_tissue_phenotype1.29551477
65MP0006035_abnormal_mitochondrial_morpho1.26677306
66MP0002638_abnormal_pupillary_reflex1.25611830
67MP0010386_abnormal_urinary_bladder1.25260389
68MP0000343_altered_response_to1.24329926
69MP0003705_abnormal_hypodermis_morpholog1.23588680
70MP0010368_abnormal_lymphatic_system1.17647181
71MP0001968_abnormal_touch/_nociception1.16831439
72MP0008872_abnormal_physiological_respon1.14495575
73MP0000759_abnormal_skeletal_muscle1.13799099
74MP0005369_muscle_phenotype1.11900381
75MP0003656_abnormal_erythrocyte_physiolo1.10971532
76MP0004019_abnormal_vitamin_homeostasis1.09576044
77MP0005647_abnormal_sex_gland1.07630877
78MP0004043_abnormal_pH_regulation1.06155639
79MP0002332_abnormal_exercise_endurance1.04982211
80MP0002138_abnormal_hepatobiliary_system1.04548292
81MP0004085_abnormal_heartbeat1.03303932
82MP0002108_abnormal_muscle_morphology1.02219524
83MP0002102_abnormal_ear_morphology1.02096180
84MP0009745_abnormal_behavioral_response1.01846451
85MP0005535_abnormal_body_temperature1.01428904
86MP0000013_abnormal_adipose_tissue0.98789732
87MP0003959_abnormal_lean_body0.98780285
88MP0005448_abnormal_energy_balance0.98659193
89MP0005266_abnormal_metabolism0.98594274
90MP0003567_abnormal_fetal_cardiomyocyte0.98164242
91MP0002736_abnormal_nociception_after0.96386002
92MP0002733_abnormal_thermal_nociception0.94003711
93MP0005334_abnormal_fat_pad0.93810316
94MP0005165_increased_susceptibility_to0.93531108
95* MP0002078_abnormal_glucose_homeostasis0.92307805
96MP0002168_other_aberrant_phenotype0.91473891
97MP0000230_abnormal_systemic_arterial0.89058111
98MP0001764_abnormal_homeostasis0.88794572
99MP0009115_abnormal_fat_cell0.88744842
100MP0001756_abnormal_urination0.88735705
101MP0003950_abnormal_plasma_membrane0.88152283
102MP0001853_heart_inflammation0.87969990
103MP0003045_fibrosis0.87847567
104MP0003566_abnormal_cell_adhesion0.87225058
105MP0005645_abnormal_hypothalamus_physiol0.86184077
106MP0004147_increased_porphyrin_level0.85693581
107MP0002928_abnormal_bile_duct0.85515029
108MP0005595_abnormal_vascular_smooth0.84456661
109MP0002127_abnormal_cardiovascular_syste0.83753896
110MP0000598_abnormal_liver_morphology0.81471394
111MP0004145_abnormal_muscle_electrophysio0.80103839
112MP0008995_early_reproductive_senescence0.80071779
113MP0002735_abnormal_chemical_nociception0.79763592
114MP0005253_abnormal_eye_physiology0.79763140
115MP0003724_increased_susceptibility_to0.79058432
116MP0000631_abnormal_neuroendocrine_gland0.78711754
117MP0003279_aneurysm0.77925256
118MP0005636_abnormal_mineral_homeostasis0.77685167
119MP0004142_abnormal_muscle_tone0.76891964
120MP0002970_abnormal_white_adipose0.76217474
121MP0002272_abnormal_nervous_system0.75247863
122MP0000003_abnormal_adipose_tissue0.73357177
123MP0009763_increased_sensitivity_to0.72885874
124MP0005187_abnormal_penis_morphology0.72246830
125MP0002909_abnormal_adrenal_gland0.71439596
126MP0008469_abnormal_protein_level0.70301117
127MP0004233_abnormal_muscle_weight0.67079803
128MP0005395_other_phenotype0.67016303
129MP0000372_irregular_coat_pigmentation0.66918980
130MP0002064_seizures0.66785344
131* MP0009642_abnormal_blood_homeostasis0.66721217
132MP0005376_homeostasis/metabolism_phenot0.66393599
133MP0008438_abnormal_cutaneous_collagen0.66171102
134* MP0000266_abnormal_heart_morphology0.65979299
135MP0003953_abnormal_hormone_level0.64839337
136MP0004510_myositis0.64145461
137MP0005084_abnormal_gallbladder_morpholo0.63067161
138MP0003633_abnormal_nervous_system0.62658492
139MP0001970_abnormal_pain_threshold0.62569359
140MP0001661_extended_life_span0.61979057
141MP0001879_abnormal_lymphatic_vessel0.61408491
142MP0009764_decreased_sensitivity_to0.60905629
143MP0005058_abnormal_lysosome_morphology0.60512058
144MP0002128_abnormal_blood_circulation0.60309808
145MP0009697_abnormal_copulation0.57466433
146MP0002136_abnormal_kidney_physiology0.57085515

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.00966885
2Abnormality of fatty-acid metabolism (HP:0004359)4.91677967
3Myoglobinuria (HP:0002913)4.82740222
4Hyperglycinuria (HP:0003108)4.51595947
5Sudden death (HP:0001699)4.49884047
6Complement deficiency (HP:0004431)4.40958713
7Dicarboxylic aciduria (HP:0003215)4.37628183
8Abnormality of dicarboxylic acid metabolism (HP:0010995)4.37628183
9Hyperammonemia (HP:0001987)4.17521452
10Rhabdomyolysis (HP:0003201)4.13456444
11Ventricular tachycardia (HP:0004756)4.11754270
12Exercise-induced myalgia (HP:0003738)3.95055827
13Hepatic necrosis (HP:0002605)3.93372500
14Abnormality of serine family amino acid metabolism (HP:0010894)3.91589782
15Abnormality of glycine metabolism (HP:0010895)3.91589782
16Ketoacidosis (HP:0001993)3.88045306
17Ketosis (HP:0001946)3.86619649
18Generalized aminoaciduria (HP:0002909)3.80518057
19Conjugated hyperbilirubinemia (HP:0002908)3.79589256
20Hyperventilation (HP:0002883)3.69054965
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.67529768
22Exercise-induced muscle cramps (HP:0003710)3.64398691
23Palpitations (HP:0001962)3.50541463
24Right ventricular cardiomyopathy (HP:0011663)3.46887589
25Increased muscle lipid content (HP:0009058)3.39807266
26Lipoatrophy (HP:0100578)3.36535642
27Xanthomatosis (HP:0000991)3.32506232
28Muscle fiber splitting (HP:0003555)3.30873137
29Thyroid-stimulating hormone excess (HP:0002925)3.25170753
30Cerebral edema (HP:0002181)3.24664205
31Hyperglycinemia (HP:0002154)3.22652338
32Nausea (HP:0002018)3.21739864
33Calf muscle hypertrophy (HP:0008981)3.13560825
34Fair hair (HP:0002286)3.13122140
35Abnormality of complement system (HP:0005339)3.09925030
36Hypoalphalipoproteinemia (HP:0003233)3.09643089
37Atrial fibrillation (HP:0005110)3.07573700
38Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06070926
39Proximal tubulopathy (HP:0000114)3.01171869
40Dilated cardiomyopathy (HP:0001644)3.00594229
41Hyperlipoproteinemia (HP:0010980)2.99975891
42Joint hemorrhage (HP:0005261)2.93543542
43Asymmetric septal hypertrophy (HP:0001670)2.91960856
44Intrahepatic cholestasis (HP:0001406)2.91562762
45Acute encephalopathy (HP:0006846)2.91138061
46Hyporeflexia of lower limbs (HP:0002600)2.89926013
47Deep venous thrombosis (HP:0002625)2.89056493
48Hepatocellular necrosis (HP:0001404)2.86545456
49Lethargy (HP:0001254)2.85587277
50Muscle fiber inclusion bodies (HP:0100299)2.84081884
51Metabolic acidosis (HP:0001942)2.82476973
52Muscle hypertrophy of the lower extremities (HP:0008968)2.82455284
53Primary atrial arrhythmia (HP:0001692)2.81590090
54Atrioventricular block (HP:0001678)2.80567682
55Supraventricular tachycardia (HP:0004755)2.73200565
56Abnormal mitochondria in muscle tissue (HP:0008316)2.72749449
57Type II lissencephaly (HP:0007260)2.70857930
58Supraventricular arrhythmia (HP:0005115)2.68634172
59Subaortic stenosis (HP:0001682)2.68558611
60Abnormality of the left ventricular outflow tract (HP:0011103)2.68558611
61Chronic hepatic failure (HP:0100626)2.68544993
62Renal cortical cysts (HP:0000803)2.67555176
63Increased connective tissue (HP:0009025)2.67294973
64Nemaline bodies (HP:0003798)2.64911559
65Hyperkalemia (HP:0002153)2.63519268
66Hypolipoproteinemia (HP:0010981)2.63102904
67Lactic acidosis (HP:0003128)2.62177161
68Abnormality of serum amino acid levels (HP:0003112)2.61726965
69Pancreatic cysts (HP:0001737)2.61098802
70Syncope (HP:0001279)2.60647870
71Increased intramyocellular lipid droplets (HP:0012240)2.60527027
72Glomerulonephritis (HP:0000099)2.60251128
73Abnormality of the calf musculature (HP:0001430)2.58390495
74Conjunctival hamartoma (HP:0100780)2.57373627
75Gaze-evoked nystagmus (HP:0000640)2.55374859
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.54788968
77Abnormality of the renal cortex (HP:0011035)2.54449204
78Inability to walk (HP:0002540)2.53919187
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.53128146
80Acute necrotizing encephalopathy (HP:0006965)2.52146556
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49636913
82Generalized hypopigmentation of hair (HP:0011358)2.49229206
83Heart block (HP:0012722)2.49054398
84Tubular atrophy (HP:0000092)2.48366716
85Tachypnea (HP:0002789)2.47819864
86Bundle branch block (HP:0011710)2.47183009
87Decreased circulating renin level (HP:0003351)2.45910128
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45739041
89Ragged-red muscle fibers (HP:0003200)2.43507811
90Abnormality of alanine metabolism (HP:0010916)2.43207675
91Hyperalaninemia (HP:0003348)2.43207675
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43207675
93Vomiting (HP:0002013)2.42814821
94Ventricular arrhythmia (HP:0004308)2.39532456
95Difficulty running (HP:0009046)2.39310373
96Abnormal atrioventricular conduction (HP:0005150)2.36272722
97Increased serum pyruvate (HP:0003542)2.36140856
98Abnormality of glycolysis (HP:0004366)2.36140856
99Increased CSF lactate (HP:0002490)2.35983428
100Abnormality of the ischium (HP:0003174)2.35354503
101Muscle stiffness (HP:0003552)2.34183917
102Systemic lupus erythematosus (HP:0002725)2.30445263
103Pancreatic fibrosis (HP:0100732)2.28919290
104Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28418764
105Pigmentary retinal degeneration (HP:0001146)2.28377329
106True hermaphroditism (HP:0010459)2.27679261
107Glycosuria (HP:0003076)2.27643256
108Abnormality of urine glucose concentration (HP:0011016)2.27643256
109Polydipsia (HP:0001959)2.24893946
110Abnormal drinking behavior (HP:0030082)2.24893946
111Hypobetalipoproteinemia (HP:0003563)2.24694591
112EMG: myopathic abnormalities (HP:0003458)2.24661733
113Mitochondrial inheritance (HP:0001427)2.24202862
114Abnormal biliary tract physiology (HP:0012439)2.22691888
115Bile duct proliferation (HP:0001408)2.22691888
116Tubulointerstitial abnormality (HP:0001969)2.22529106
117Facial shape deformation (HP:0011334)2.21027596
118Potter facies (HP:0002009)2.21027596
119Tubulointerstitial nephritis (HP:0001970)2.19673304
120Delayed CNS myelination (HP:0002188)2.17889563
121Neoplasm of head and neck (HP:0012288)2.17609087
122Esophageal neoplasm (HP:0100751)2.17609087
123Gout (HP:0001997)2.15612881
124Hypoplastic ischia (HP:0003175)2.15056667
125Congenital stationary night blindness (HP:0007642)2.15046880
126Lipid accumulation in hepatocytes (HP:0006561)2.14640750
127Large for gestational age (HP:0001520)2.13887788
128Multiple enchondromatosis (HP:0005701)2.12791045
129Neonatal respiratory distress (HP:0002643)2.12675560
130Nephritis (HP:0000123)2.12348532
131Spontaneous abortion (HP:0005268)2.12151082
132Fat malabsorption (HP:0002630)2.11588994
133Respiratory failure (HP:0002878)2.10854888
134Tubulointerstitial fibrosis (HP:0005576)2.10459354
135Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10042866
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10042866
137Methylmalonic aciduria (HP:0012120)2.09974981
138Abnormality of purine metabolism (HP:0004352)2.08165972
139Progressive macrocephaly (HP:0004481)2.07325648
140Abnormality of potassium homeostasis (HP:0011042)2.06969325
141Neonatal death (HP:0003811)2.06258185
142Hypokalemia (HP:0002900)2.04563250
143Prolonged partial thromboplastin time (HP:0003645)2.03137345
144Nephronophthisis (HP:0000090)2.02680182
145Molar tooth sign on MRI (HP:0002419)2.01399729
146Abnormality of midbrain morphology (HP:0002418)2.01399729
147Abnormality of the renal medulla (HP:0100957)2.00989126
148Broad-based gait (HP:0002136)2.00867705
149Hydroxyprolinuria (HP:0003080)2.00744690
150Abnormality of proline metabolism (HP:0010907)2.00744690
151Epidermoid cyst (HP:0200040)2.00667319
152Arthropathy (HP:0003040)1.94081619
153Progressive inability to walk (HP:0002505)1.93600949
154Male pseudohermaphroditism (HP:0000037)1.93146412
155Blue irides (HP:0000635)1.91121838
156Polyuria (HP:0000103)1.90198563
157Decreased central vision (HP:0007663)1.89927212
158Distal arthrogryposis (HP:0005684)1.89804335
159Absent speech (HP:0001344)1.88821855
160Steatorrhea (HP:0002570)1.86772856
161Abnormality of nucleobase metabolism (HP:0010932)1.86383768
162Hypokalemic alkalosis (HP:0001949)1.83985768
163Abnormal urine output (HP:0012590)1.83944475
164Abnormality of the intrinsic pathway (HP:0010989)1.83264973
165Attenuation of retinal blood vessels (HP:0007843)1.82415407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.43373907
2BCKDK5.24884077
3PDK33.91112868
4PDK43.91112868
5TRIB33.89947193
6TTN3.76913762
7WNK33.66084368
8PKN23.45165396
9LMTK22.82136369
10OBSCN2.71794448
11MYLK2.58698612
12PDK22.50368317
13TIE12.31187198
14CASK2.19816416
15PHKG22.19081466
16PHKG12.19081466
17NEK12.14955486
18CAMKK22.07195812
19STK241.97761462
20SIK11.89174279
21GRK11.85842978
22AKT31.84148510
23PIK3CA1.82361194
24MAP4K21.81549607
25ADRBK21.77156144
26FLT31.75643330
27NME21.75237533
28ERN11.73444971
29FGFR41.70690025
30PINK11.70647033
31PNCK1.69258040
32MAPK151.55780707
33DAPK21.55228557
34DMPK1.54988117
35MAPK131.54679692
36NEK91.53615274
37NTRK31.47007331
38KDR1.42560530
39BMPR1B1.38528679
40BLK1.36319484
41NUAK11.33479201
42MAP2K31.31668773
43WNK41.27495107
44PRKAA21.20732633
45OXSR11.20465936
46MARK11.19286724
47ILK1.17182048
48CAMK1G1.16330337
49TGFBR21.13439572
50MST1R1.12641986
51SGK21.10851935
52PRKCE1.10025815
53ACVR1B1.09755309
54MUSK1.07527421
55FER1.03824243
56IRAK11.02326163
57INSRR1.01788846
58MAP3K70.97462284
59EPHB10.96301475
60MAPKAPK50.94416997
61TBK10.93477865
62MAPK110.91659959
63EEF2K0.91232807
64STK38L0.89352327
65MAP3K30.89181228
66PIK3CG0.88409318
67CAMK1D0.86837861
68TAOK30.86610971
69PRKD10.84737913
70PTK60.84501134
71MAPK120.84408014
72CAMK10.84364817
73RIPK10.84321332
74PRKAA10.83877768
75TYK20.83705825
76GRK70.83131410
77LRRK20.82783475
78MAPKAPK30.81026311
79ADRBK10.80651599
80NLK0.78999375
81TNK20.78057824
82TRPM70.77629945
83STK380.75542743
84PRKG10.73271769
85SGK4940.72098658
86SGK2230.72098658
87PRKCG0.69343385
88TNIK0.67383935
89MKNK20.65987248
90STK40.63799375
91PDPK10.62995788
92ABL20.62757044
93BRSK20.60988739
94MAP3K50.59749260
95MAP3K40.59269366
96CAMK2D0.56605565
97PRKG20.55969250
98JAK20.55664626
99JAK10.54461711
100PKN10.53049569
101TEC0.52488456
102MAP3K20.51595132
103GRK50.51518904
104PTK2B0.51354194
105PRKACG0.51158068
106BCR0.50043466
107ZAK0.48197966
108PDK10.48027373
109EPHA40.47660077
110MAP2K40.46577231
111IGF1R0.46383213
112DYRK20.46184068
113EPHB20.46114968
114MAP3K110.45890668
115CAMK2A0.45820557
116PRKCZ0.45171987
117MAPK70.43687905
118MAP2K10.43247746
119CDK40.43123129
120PAK30.42792508
121SGK10.41427403
122ERBB20.41240401
123KIT0.39685150
124MAP2K70.39563735
125STK110.39505083
126ROCK10.38892024
127PLK20.37796136
128EPHA30.37167517
129HIPK20.36575355
130DAPK30.36452958
131MAPK40.36126547
132FGFR30.35776512
133RPS6KA30.34935221
134SGK30.34868602
135PDGFRA0.34505658
136STK30.32794140
137JAK30.32294558
138CAMK40.31630338
139AKT20.31406797
140STK390.30789040
141IRAK30.29973403
142MAP2K20.29951872
143PIM20.29629393
144CAMK2G0.29230820
145LATS10.29182296
146CDK60.29077364
147TGFBR10.28336856
148MAP4K10.26370583
149RPS6KC10.25292050
150RPS6KL10.25292050
151RPS6KA60.25165288
152ZAP700.24390408
153GSK3A0.24220524
154MAP2K60.22276058
155PRKACB0.21713174
156MTOR0.20577410
157RET0.19898676
158PRKACA0.19898582
159MET0.19687016
160STK100.19040282

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.55848240
2Propanoate metabolism_Homo sapiens_hsa006403.88001883
3* Fatty acid degradation_Homo sapiens_hsa000713.68624498
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.68162574
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.48743042
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.97414987
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88485044
8* Fatty acid metabolism_Homo sapiens_hsa012122.84649907
9Carbon metabolism_Homo sapiens_hsa012002.50078069
10Butanoate metabolism_Homo sapiens_hsa006502.32202514
11Pyruvate metabolism_Homo sapiens_hsa006202.23864120
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.23000764
13Tryptophan metabolism_Homo sapiens_hsa003802.20052726
14* PPAR signaling pathway_Homo sapiens_hsa033202.18656827
15Fatty acid elongation_Homo sapiens_hsa000622.02710034
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00053059
17Peroxisome_Homo sapiens_hsa041461.94095007
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90749672
19Arginine biosynthesis_Homo sapiens_hsa002201.86299562
20Nitrogen metabolism_Homo sapiens_hsa009101.85307218
21beta-Alanine metabolism_Homo sapiens_hsa004101.83732308
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74259600
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56342972
24Parkinsons disease_Homo sapiens_hsa050121.51518194
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50621193
26Oxidative phosphorylation_Homo sapiens_hsa001901.47535199
27Biosynthesis of amino acids_Homo sapiens_hsa012301.43591609
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39537402
29Starch and sucrose metabolism_Homo sapiens_hsa005001.34190229
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33718523
31Cardiac muscle contraction_Homo sapiens_hsa042601.27818429
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22096767
33Complement and coagulation cascades_Homo sapiens_hsa046101.17996600
34Caffeine metabolism_Homo sapiens_hsa002321.17368351
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13654547
36Fatty acid biosynthesis_Homo sapiens_hsa000611.12793325
37Phenylalanine metabolism_Homo sapiens_hsa003601.11332342
38Circadian rhythm_Homo sapiens_hsa047101.08286847
39Sulfur metabolism_Homo sapiens_hsa009201.07132792
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01857222
41Fat digestion and absorption_Homo sapiens_hsa049751.01380683
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99268979
43Chemical carcinogenesis_Homo sapiens_hsa052040.97860783
44Alzheimers disease_Homo sapiens_hsa050100.97142172
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.93995322
46Histidine metabolism_Homo sapiens_hsa003400.92521039
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.92035410
48Pentose phosphate pathway_Homo sapiens_hsa000300.90506723
49Tyrosine metabolism_Homo sapiens_hsa003500.90452986
50Selenocompound metabolism_Homo sapiens_hsa004500.88833079
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87431628
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87321717
53Arginine and proline metabolism_Homo sapiens_hsa003300.86649240
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86239526
55Bile secretion_Homo sapiens_hsa049760.85517564
56Lysine degradation_Homo sapiens_hsa003100.84597811
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.82974955
58Folate biosynthesis_Homo sapiens_hsa007900.81930160
59Huntingtons disease_Homo sapiens_hsa050160.80912722
60Glycerolipid metabolism_Homo sapiens_hsa005610.80743407
61Dilated cardiomyopathy_Homo sapiens_hsa054140.80414822
62Retinol metabolism_Homo sapiens_hsa008300.77037540
63Ether lipid metabolism_Homo sapiens_hsa005650.76635387
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75567535
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.72909191
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72613763
67Staphylococcus aureus infection_Homo sapiens_hsa051500.72559924
68Insulin resistance_Homo sapiens_hsa049310.71836278
69Sulfur relay system_Homo sapiens_hsa041220.71246022
70Ovarian steroidogenesis_Homo sapiens_hsa049130.69023498
71Phototransduction_Homo sapiens_hsa047440.68963900
72Glutathione metabolism_Homo sapiens_hsa004800.67109757
73ABC transporters_Homo sapiens_hsa020100.65831864
74Serotonergic synapse_Homo sapiens_hsa047260.65334989
75Galactose metabolism_Homo sapiens_hsa000520.61370705
76Fructose and mannose metabolism_Homo sapiens_hsa000510.58960455
77* Metabolic pathways_Homo sapiens_hsa011000.56174306
78Nicotine addiction_Homo sapiens_hsa050330.52083618
79AMPK signaling pathway_Homo sapiens_hsa041520.51682862
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.50704440
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49188077
82Glucagon signaling pathway_Homo sapiens_hsa049220.45195095
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43767076
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42283393
85Vitamin digestion and absorption_Homo sapiens_hsa049770.42232906
86Olfactory transduction_Homo sapiens_hsa047400.41892847
87Mineral absorption_Homo sapiens_hsa049780.41380886
88Vitamin B6 metabolism_Homo sapiens_hsa007500.40952039
89Insulin signaling pathway_Homo sapiens_hsa049100.38893648
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37647930
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.34928940
92Taste transduction_Homo sapiens_hsa047420.34716298
93Viral myocarditis_Homo sapiens_hsa054160.33648388
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31354551
95Glutamatergic synapse_Homo sapiens_hsa047240.31045731
96Morphine addiction_Homo sapiens_hsa050320.29701855
97GABAergic synapse_Homo sapiens_hsa047270.28613878
98Insulin secretion_Homo sapiens_hsa049110.25924445
99Circadian entrainment_Homo sapiens_hsa047130.24785110
100Calcium signaling pathway_Homo sapiens_hsa040200.23649298
101Long-term depression_Homo sapiens_hsa047300.22759094
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22393542
103Salivary secretion_Homo sapiens_hsa049700.21956753
104Renin secretion_Homo sapiens_hsa049240.21027808
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20110036
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19743324
107Pancreatic secretion_Homo sapiens_hsa049720.18846691
108Oxytocin signaling pathway_Homo sapiens_hsa049210.18285266
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17411588
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.15741215
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.15012872
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13032684
113HIF-1 signaling pathway_Homo sapiens_hsa040660.07880732
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07619900
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05428488
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04518465
117One carbon pool by folate_Homo sapiens_hsa006700.03204491
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.01546656
119Linoleic acid metabolism_Homo sapiens_hsa005910.00516482
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0658241
121Amoebiasis_Homo sapiens_hsa05146-0.0630848
122Regulation of autophagy_Homo sapiens_hsa04140-0.0599855
123Legionellosis_Homo sapiens_hsa05134-0.0580975
124Focal adhesion_Homo sapiens_hsa04510-0.0547281
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0354798
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0188903
127Steroid biosynthesis_Homo sapiens_hsa00100-0.0122797

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