ACACA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.25731875
2regulation of sequestering of triglyceride (GO:0010889)6.55067119
3alpha-linolenic acid metabolic process (GO:0036109)6.29679766
4triglyceride catabolic process (GO:0019433)6.15565353
5positive regulation of fatty acid beta-oxidation (GO:0032000)5.82034629
6acylglycerol catabolic process (GO:0046464)5.78215909
7neutral lipid catabolic process (GO:0046461)5.78215909
8nuclear pore complex assembly (GO:0051292)5.64856244
9* fatty-acyl-CoA biosynthetic process (GO:0046949)5.60277768
10* acyl-CoA biosynthetic process (GO:0071616)5.39636742
11* thioester biosynthetic process (GO:0035384)5.39636742
12* triglyceride biosynthetic process (GO:0019432)5.31161471
13* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.22456248
14valine metabolic process (GO:0006573)5.15804832
15* neutral lipid biosynthetic process (GO:0046460)5.15279921
16* acylglycerol biosynthetic process (GO:0046463)5.15279921
17white fat cell differentiation (GO:0050872)5.13353099
18positive regulation of fatty acid oxidation (GO:0046321)5.12617921
19* acetyl-CoA metabolic process (GO:0006084)4.97827952
20nuclear pore organization (GO:0006999)4.91071361
21* fatty-acyl-CoA metabolic process (GO:0035337)4.80144091
22regulation of fatty acid beta-oxidation (GO:0031998)4.77925296
23brown fat cell differentiation (GO:0050873)4.75553342
24* fatty acid transmembrane transport (GO:1902001)4.73119951
25* biotin metabolic process (GO:0006768)4.66872168
26plasma lipoprotein particle clearance (GO:0034381)4.64333613
27* long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.62762360
28positive regulation of lipid catabolic process (GO:0050996)4.62515105
29complement activation, alternative pathway (GO:0006957)4.62120123
30regulation of triglyceride catabolic process (GO:0010896)4.61430103
31regulation of cholesterol storage (GO:0010885)4.52644367
32fatty acid beta-oxidation (GO:0006635)4.42983429
33* triglyceride metabolic process (GO:0006641)4.42870527
34glycerolipid catabolic process (GO:0046503)4.27861229
35fatty acid homeostasis (GO:0055089)4.26302041
36* acylglycerol metabolic process (GO:0006639)4.21920153
37regulation of fatty acid oxidation (GO:0046320)4.21515357
38pore complex assembly (GO:0046931)4.18670964
39* neutral lipid metabolic process (GO:0006638)4.15386115
40negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.11165909
41fatty acid oxidation (GO:0019395)4.07592240
42* carnitine shuttle (GO:0006853)4.06778062
43linoleic acid metabolic process (GO:0043651)4.00057355
44lipid oxidation (GO:0034440)3.99303180
45fatty acid catabolic process (GO:0009062)3.96202703
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.90959788
47DNA unwinding involved in DNA replication (GO:0006268)3.90470828
48triglyceride homeostasis (GO:0070328)3.87493258
49acylglycerol homeostasis (GO:0055090)3.87493258
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.86423236
51L-phenylalanine catabolic process (GO:0006559)3.86423236
52regulation of triglyceride metabolic process (GO:0090207)3.86003979
53regulation of translational fidelity (GO:0006450)3.85021487
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.84673301
55regulation of triglyceride biosynthetic process (GO:0010866)3.74441102
56sulfur amino acid catabolic process (GO:0000098)3.73767363
57positive regulation of fatty acid metabolic process (GO:0045923)3.71531640
58positive regulation of triglyceride metabolic process (GO:0090208)3.65275986
59phospholipid homeostasis (GO:0055091)3.64833439
60* acyl-CoA metabolic process (GO:0006637)3.63748339
61* thioester metabolic process (GO:0035383)3.63748339
62positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.63383879
63lipid storage (GO:0019915)3.61549201
64ethanol oxidation (GO:0006069)3.60602248
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60427052
66lipid particle organization (GO:0034389)3.59380154
67branched-chain amino acid metabolic process (GO:0009081)3.59251162
68urea metabolic process (GO:0019627)3.56380325
69urea cycle (GO:0000050)3.56380325
70branched-chain amino acid catabolic process (GO:0009083)3.55214611
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55204007
72L-phenylalanine metabolic process (GO:0006558)3.55204007
73short-chain fatty acid metabolic process (GO:0046459)3.52758830
74tricarboxylic acid metabolic process (GO:0072350)3.47893801
75regulation of lipid catabolic process (GO:0050994)3.45475395
76mitotic sister chromatid cohesion (GO:0007064)3.45065993
77negative regulation of lipase activity (GO:0060192)3.43429024
78monocarboxylic acid catabolic process (GO:0072329)3.40809538
79pre-miRNA processing (GO:0031054)3.38372866
80glucocorticoid receptor signaling pathway (GO:0042921)3.34246133
81positive regulation of lipid storage (GO:0010884)3.33206675
82regulation of RNA export from nucleus (GO:0046831)3.30145887
83cytoskeletal anchoring at plasma membrane (GO:0007016)3.29937687
84pentose-phosphate shunt (GO:0006098)3.29532656
85COPI coating of Golgi vesicle (GO:0048205)3.28939138
86Golgi transport vesicle coating (GO:0048200)3.28939138
872-oxoglutarate metabolic process (GO:0006103)3.27978413
88NADPH regeneration (GO:0006740)3.26202274
89regulation of protein activation cascade (GO:2000257)3.26083210
90desmosome organization (GO:0002934)3.25844156
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25498976
92NLS-bearing protein import into nucleus (GO:0006607)3.25327474
93lysine metabolic process (GO:0006553)3.24520058
94lysine catabolic process (GO:0006554)3.24520058
95mitotic chromosome condensation (GO:0007076)3.21242781
96negative regulation of DNA repair (GO:0045738)3.20834267
97paraxial mesoderm development (GO:0048339)3.19665856
98nitrogen cycle metabolic process (GO:0071941)3.19584302
99regulation of complement activation (GO:0030449)3.17465545
100pantothenate metabolic process (GO:0015939)3.17352353
101positive regulation of histone deacetylation (GO:0031065)3.16544589
102alanine transport (GO:0032328)3.16368073
103growth hormone receptor signaling pathway (GO:0060396)3.16159015
104positive regulation of glycolytic process (GO:0045821)3.12361779
105branching involved in prostate gland morphogenesis (GO:0060442)3.08765683
106CDP-diacylglycerol biosynthetic process (GO:0016024)3.06220783
107negative regulation of lipid storage (GO:0010888)3.05598130
108hemidesmosome assembly (GO:0031581)3.05593035
109positive regulation of glucose import (GO:0046326)3.04856451
110* carnitine transmembrane transport (GO:1902603)3.02343570
111aromatic amino acid family catabolic process (GO:0009074)3.01167624
112amino-acid betaine metabolic process (GO:0006577)3.00693570
113* coenzyme A metabolic process (GO:0015936)3.00435180
114nucleobase catabolic process (GO:0046113)3.00020462
115heterochromatin organization (GO:0070828)2.98329242
116response to dietary excess (GO:0002021)2.97446306
117negative regulation of fatty acid biosynthetic process (GO:0045717)2.96041892
118positive regulation of cholesterol transport (GO:0032376)2.94979959
119positive regulation of sterol transport (GO:0032373)2.94979959
120diacylglycerol metabolic process (GO:0046339)2.93764626
121NADP metabolic process (GO:0006739)2.92555832
122apical protein localization (GO:0045176)2.92380050
123establishment of apical/basal cell polarity (GO:0035089)2.85507028
124regulation of nucleobase-containing compound transport (GO:0032239)2.83990674
125regulation of NFAT protein import into nucleus (GO:0051532)2.83208025
126L-serine metabolic process (GO:0006563)2.81956575
127notochord development (GO:0030903)2.78008639
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74243562
129establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.74094102
130sister chromatid segregation (GO:0000819)2.73164086
131iron ion import (GO:0097286)2.71053434
132protein complex localization (GO:0031503)2.66398868
133DNA duplex unwinding (GO:0032508)2.64965211
134semaphorin-plexin signaling pathway (GO:0071526)2.64837500
135embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63963119
136proline biosynthetic process (GO:0006561)2.61760045
137cytoplasmic mRNA processing body assembly (GO:0033962)2.59479573
138asymmetric protein localization (GO:0008105)2.57945952
139regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57015314
140adherens junction assembly (GO:0034333)2.56617831
141mitotic sister chromatid segregation (GO:0000070)2.56036729
142protein-DNA complex disassembly (GO:0032986)2.55227059
143nucleosome disassembly (GO:0006337)2.55227059
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.53274748
145establishment of monopolar cell polarity (GO:0061162)2.53274748
146peptidyl-lysine dimethylation (GO:0018027)2.52428423
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.51641354
148DNA geometric change (GO:0032392)2.51276603
149activation of Rac GTPase activity (GO:0032863)2.50073405
150artery development (GO:0060840)2.49362322
151hippo signaling (GO:0035329)2.49000444
152convergent extension (GO:0060026)2.46388380
153protein export from nucleus (GO:0006611)2.44777211
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44335187
155protein localization to microtubule (GO:0035372)2.43668294
156positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.43210718
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.42120134
158regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.41743698
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.41547656
160cellular protein complex localization (GO:0034629)2.41270531
161cell-substrate adherens junction assembly (GO:0007045)2.41206385
162focal adhesion assembly (GO:0048041)2.41206385
163morphogenesis of an epithelial sheet (GO:0002011)2.40585054
164mitotic nuclear envelope disassembly (GO:0007077)2.40008331
165polarized epithelial cell differentiation (GO:0030859)2.39625298
166corticosteroid receptor signaling pathway (GO:0031958)2.38974317
167maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36421093
168COPII vesicle coating (GO:0048208)2.35247139
169negative regulation of histone methylation (GO:0031061)2.34973493
170DNA replication initiation (GO:0006270)2.34118500
171cell-substrate junction assembly (GO:0007044)2.34027478
172homocysteine metabolic process (GO:0050667)2.33704208
173regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.32759086
174nuclear envelope disassembly (GO:0051081)2.32604031
175membrane disassembly (GO:0030397)2.32604031
176establishment or maintenance of apical/basal cell polarity (GO:0035088)2.31933781
177establishment or maintenance of bipolar cell polarity (GO:0061245)2.31933781
178synaptic vesicle docking involved in exocytosis (GO:0016081)2.30644778
179gap junction assembly (GO:0016264)2.30177291
180neural tube development (GO:0021915)2.28695730
181negative regulation of keratinocyte proliferation (GO:0010839)2.27788864
182regulation of glucose import in response to insulin stimulus (GO:2001273)2.25964139
183regulation of cholesterol biosynthetic process (GO:0045540)2.25670535
184protein retention in ER lumen (GO:0006621)2.25588626
185DNA topological change (GO:0006265)2.24975968
186glutamine metabolic process (GO:0006541)2.24346567
187prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.23844662
188chromosome condensation (GO:0030261)2.21995922
189vesicle coating (GO:0006901)2.21448726
190double-strand break repair via nonhomologous end joining (GO:0006303)2.18562925
191non-recombinational repair (GO:0000726)2.18562925
192positive regulation of cell cycle checkpoint (GO:1901978)2.17908758
193protein localization to chromosome, centromeric region (GO:0071459)2.16899375
194DNA conformation change (GO:0071103)2.15552215
195Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.14318332
196stress granule assembly (GO:0034063)2.14016838
197epithelial cell-cell adhesion (GO:0090136)2.13580450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25620188
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.08299757
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.77225076
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.34429015
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.21340663
6AR_21909140_ChIP-Seq_LNCAP_Human4.12310810
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.96356049
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.67690371
9CLOCK_20551151_ChIP-Seq_293T_Human3.62498076
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.27488328
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92107410
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.82218590
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.74147368
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73041088
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.29379559
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.16630789
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10477530
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.3058218
19CHD1_26751641_Chip-Seq_LNCaP_Human1.98684932
20* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96219341
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85940791
22PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.82537747
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82514519
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80387868
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79892366
26ZNF263_19887448_ChIP-Seq_K562_Human1.79667597
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78314530
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70843443
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70725319
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.69960995
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65274096
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.63465580
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61604551
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.60104455
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59087437
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56143265
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54377691
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52443506
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.52201204
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50989871
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48531276
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47339310
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46893554
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46541180
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44589025
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43099993
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42676015
48MYC_22102868_ChIP-Seq_BL_Human1.41530883
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41038597
50RACK7_27058665_Chip-Seq_MCF-7_Human1.40871318
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40851400
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40522851
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38913136
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37748859
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37004954
56* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.36082012
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.34850283
58* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34475203
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33961282
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33403459
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33386512
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.32937537
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32829922
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.29385202
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.28989520
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28589281
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25824423
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24160416
69* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23843402
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23144853
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22982660
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21655776
73KDM5A_27292631_Chip-Seq_BREAST_Human1.21333383
74GATA1_22025678_ChIP-Seq_K562_Human1.20353399
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19581380
76XRN2_22483619_ChIP-Seq_HELA_Human1.19451525
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19055939
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18796327
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18427395
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16343740
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15829845
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.15219809
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.13280534
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13168507
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12090991
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12026840
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11218655
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08757621
89* CREB1_26743006_Chip-Seq_LNCaP_Human1.06223103
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05927690
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04823568
92ATF3_27146783_Chip-Seq_COLON_Human1.04005121
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03498814
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03455302
95* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02848619
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02105529
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01458164
98* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99941688
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98888816
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98186268
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96781639
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96559364
103RARB_27405468_Chip-Seq_BRAIN_Mouse0.96431543
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96397325
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.96009140
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.95631622
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.95631622
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95468753
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.94942717
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94506220
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.93638268
112MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93622001
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93341637
114* PIAS1_25552417_ChIP-Seq_VCAP_Human0.92951123
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92604734
116GATA6_25053715_ChIP-Seq_YYC3_Human0.92524586
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92502071
118AHR_22903824_ChIP-Seq_MCF-7_Human0.92187424
119* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91802203
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90824212
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90199498
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89392801
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88703384
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86442178
125RXR_22108803_ChIP-Seq_LS180_Human0.86423704
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.86089615
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85821721
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85164610
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83900517
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.83325846
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83232104
132CJUN_26792858_Chip-Seq_BT549_Human0.82956465
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82932724
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.82039250
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81886535
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81562420
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81562420
138* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81371164
139KDM2B_26808549_Chip-Seq_K562_Human0.81315275
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80284316
141TP53_16413492_ChIP-PET_HCT116_Human0.80251734
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80160195
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.79996244
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78645215
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78398956
146AR_21572438_ChIP-Seq_LNCaP_Human0.78163021
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.75188623
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74569926
149* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74444719
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74401738
151DROSHA_22980978_ChIP-Seq_HELA_Human0.73820932
152GATA1_19941826_ChIP-Seq_K562_Human0.73329268
153* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72824125
154GATA2_21666600_ChIP-Seq_HMVEC_Human0.72363261
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71508212
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69395137
157GBX2_23144817_ChIP-Seq_PC3_Human0.68527647
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.67939643
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67897601
160HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67790020
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67289679
162VDR_24787735_ChIP-Seq_THP-1_Human0.67155403
163SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67132904
164ELK4_26923725_Chip-Seq_MESODERM_Mouse0.66529140
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65124925
166GATA4_25053715_ChIP-Seq_YYC3_Human0.64742717
167SOX2_21211035_ChIP-Seq_LN229_Gbm0.64740255
168KLF4_19829295_ChIP-Seq_ESCs_Human0.62217754
169* STAT3_23295773_ChIP-Seq_U87_Human0.61862972
170GATA2_19941826_ChIP-Seq_K562_Human0.61609266
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.61508011
172* BCAT_22108803_ChIP-Seq_LS180_Human0.61335580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.95258403
2MP0005666_abnormal_adipose_tissue4.77372944
3MP0002139_abnormal_hepatobiliary_system4.61191164
4MP0004130_abnormal_muscle_cell4.21246563
5MP0004185_abnormal_adipocyte_glucose4.05404601
6MP0008438_abnormal_cutaneous_collagen3.87754704
7MP0010329_abnormal_lipoprotein_level3.79117436
8MP0005365_abnormal_bile_salt3.73164911
9MP0005360_urolithiasis3.69761419
10MP0005375_adipose_tissue_phenotype3.26469362
11MP0000537_abnormal_urethra_morphology3.14954232
12MP0002971_abnormal_brown_adipose3.07938890
13MP0003705_abnormal_hypodermis_morpholog2.94467800
14MP0005085_abnormal_gallbladder_physiolo2.77022057
15* MP0002118_abnormal_lipid_homeostasis2.60473192
16MP0005275_abnormal_skin_tensile2.47804980
17MP0005334_abnormal_fat_pad2.45987474
18MP0002009_preneoplasia2.45220254
19MP0009115_abnormal_fat_cell2.28826194
20MP0004858_abnormal_nervous_system2.24224067
21MP0000566_synostosis2.23011871
22MP0001881_abnormal_mammary_gland2.22096189
23MP0004233_abnormal_muscle_weight2.19035479
24MP0003191_abnormal_cellular_cholesterol2.18931841
25MP0001661_extended_life_span2.17141135
26MP0002970_abnormal_white_adipose2.05600338
27* MP0000609_abnormal_liver_physiology1.99794716
28MP0008057_abnormal_DNA_replication1.99559940
29MP0000003_abnormal_adipose_tissue1.97289000
30MP0003693_abnormal_embryo_hatching1.92225931
31MP0003252_abnormal_bile_duct1.91270217
32MP0000579_abnormal_nail_morphology1.85439757
33MP0002837_dystrophic_cardiac_calcinosis1.84498467
34MP0004957_abnormal_blastocyst_morpholog1.84171141
35MP0003941_abnormal_skin_development1.83310187
36MP0000013_abnormal_adipose_tissue1.80073756
37MP0010094_abnormal_chromosome_stability1.75585755
38MP0003315_abnormal_perineum_morphology1.74640407
39MP0003890_abnormal_embryonic-extraembry1.73373951
40MP0003111_abnormal_nucleus_morphology1.72396286
41MP0002876_abnormal_thyroid_physiology1.71857540
42MP0005535_abnormal_body_temperature1.70421323
43MP0003690_abnormal_glial_cell1.65970902
44MP0008875_abnormal_xenobiotic_pharmacok1.58044825
45MP0002254_reproductive_system_inflammat1.56967585
46MP0003123_paternal_imprinting1.55978216
47* MP0001730_embryonic_growth_arrest1.49591323
48MP0004264_abnormal_extraembryonic_tissu1.49089596
49MP0008932_abnormal_embryonic_tissue1.49037326
50MP0005448_abnormal_energy_balance1.48918212
51MP0005332_abnormal_amino_acid1.44979929
52MP0004272_abnormal_basement_membrane1.44168440
53MP0002697_abnormal_eye_size1.43065927
54MP0003959_abnormal_lean_body1.42574016
55MP0002084_abnormal_developmental_patter1.40909438
56MP0005623_abnormal_meninges_morphology1.39272210
57* MP0005380_embryogenesis_phenotype1.38990654
58* MP0001672_abnormal_embryogenesis/_devel1.38990654
59MP0003942_abnormal_urinary_system1.37946352
60MP0003077_abnormal_cell_cycle1.37628923
61* MP0003984_embryonic_growth_retardation1.36487666
62MP0003937_abnormal_limbs/digits/tail_de1.35300901
63MP0009780_abnormal_chondrocyte_physiolo1.33035110
64* MP0002088_abnormal_embryonic_growth/wei1.32033257
65MP0005409_darkened_coat_color1.30035060
66MP0005452_abnormal_adipose_tissue1.29048343
67MP0000534_abnormal_ureter_morphology1.28695649
68* MP0002078_abnormal_glucose_homeostasis1.26447788
69MP0002085_abnormal_embryonic_tissue1.25164547
70MP0004197_abnormal_fetal_growth/weight/1.24379759
71MP0002234_abnormal_pharynx_morphology1.23692611
72MP0003283_abnormal_digestive_organ1.22859593
73MP0000762_abnormal_tongue_morphology1.18002088
74MP0010030_abnormal_orbit_morphology1.16816323
75MP0005083_abnormal_biliary_tract1.16210855
76MP0002822_catalepsy1.15898032
77MP0005645_abnormal_hypothalamus_physiol1.15637939
78MP0000350_abnormal_cell_proliferation1.14863709
79MP0001849_ear_inflammation1.13664643
80MP0009840_abnormal_foam_cell1.12403695
81MP0002086_abnormal_extraembryonic_tissu1.12305914
82MP0005187_abnormal_penis_morphology1.12245378
83MP0003861_abnormal_nervous_system1.11399251
84* MP0002080_prenatal_lethality1.11243277
85MP0003385_abnormal_body_wall1.10648333
86MP0003115_abnormal_respiratory_system1.09390090
87MP0000428_abnormal_craniofacial_morphol1.08993954
88MP0001697_abnormal_embryo_size1.08304286
89MP0003045_fibrosis1.07867203
90MP0009053_abnormal_anal_canal1.06848252
91MP0001666_abnormal_nutrient_absorption1.06763078
92* MP0005584_abnormal_enzyme/coenzyme_acti1.06031416
93MP0002111_abnormal_tail_morphology1.05731389
94MP0000432_abnormal_head_morphology1.05444927
95MP0001299_abnormal_eye_distance/1.05283627
96MP0005257_abnormal_intraocular_pressure1.04775237
97MP0004270_analgesia1.04264368
98MP0010678_abnormal_skin_adnexa1.03830761
99MP0002796_impaired_skin_barrier1.03238824
100MP0005647_abnormal_sex_gland1.03002886
101MP0002060_abnormal_skin_morphology1.02931823
102MP0001346_abnormal_lacrimal_gland1.01933230
103MP0002168_other_aberrant_phenotype1.01676884
104MP0003935_abnormal_craniofacial_develop1.00983149
105MP0005076_abnormal_cell_differentiation0.99541950
106MP0002877_abnormal_melanocyte_morpholog0.98275293
107MP0003755_abnormal_palate_morphology0.97296758
108MP0000778_abnormal_nervous_system0.97238570
109MP0010234_abnormal_vibrissa_follicle0.96194890
110MP0003011_delayed_dark_adaptation0.96190661
111MP0003806_abnormal_nucleotide_metabolis0.95485437
112MP0002249_abnormal_larynx_morphology0.95210194
113MP0004019_abnormal_vitamin_homeostasis0.95117486
114* MP0005319_abnormal_enzyme/_coenzyme0.92860802
115MP0001177_atelectasis0.92673305
116MP0000427_abnormal_hair_cycle0.91645020
117MP0009672_abnormal_birth_weight0.88768019
118MP0002089_abnormal_postnatal_growth/wei0.88192434
119MP0000377_abnormal_hair_follicle0.87664510
120MP0000733_abnormal_muscle_development0.87368251
121MP0005501_abnormal_skin_physiology0.85777197
122MP0000569_abnormal_digit_pigmentation0.84421908
123MP0003566_abnormal_cell_adhesion0.83378197
124MP0010307_abnormal_tumor_latency0.83049405
125MP0000467_abnormal_esophagus_morphology0.81990988
126MP0008961_abnormal_basal_metabolism0.81776141
127MP0000462_abnormal_digestive_system0.81742496
128MP0002098_abnormal_vibrissa_morphology0.79141238
129MP0000598_abnormal_liver_morphology0.79134198
130MP0002116_abnormal_craniofacial_bone0.77227006
131MP0002081_perinatal_lethality0.76113971
132MP0002184_abnormal_innervation0.75888510
133MP0001764_abnormal_homeostasis0.74218376
134MP0000955_abnormal_spinal_cord0.73336794
135MP0001348_abnormal_lacrimal_gland0.72521430
136MP0009697_abnormal_copulation0.72493665
137MP0002092_abnormal_eye_morphology0.72036509
138MP0000604_amyloidosis0.71505405
139MP0000678_abnormal_parathyroid_gland0.71452128
140MP0004859_abnormal_synaptic_plasticity0.70933856
141MP0003186_abnormal_redox_activity0.70930110
142MP0010630_abnormal_cardiac_muscle0.70290467
143MP0003948_abnormal_gas_homeostasis0.70041137
144MP0009763_increased_sensitivity_to0.69971227
145MP0006138_congestive_heart_failure0.69497341
146* MP0003953_abnormal_hormone_level0.68119979
147MP0003300_gastrointestinal_ulcer0.67844969
148MP0003950_abnormal_plasma_membrane0.63076727
149MP0002166_altered_tumor_susceptibility0.62914548
150MP0000627_abnormal_mammary_gland0.61115857
151MP0009643_abnormal_urine_homeostasis0.58840506
152MP0003868_abnormal_feces_composition0.57916703
153MP0002295_abnormal_pulmonary_circulatio0.56687640
154MP0003724_increased_susceptibility_to0.56041569
155MP0005248_abnormal_Harderian_gland0.56015215
156MP0001756_abnormal_urination0.55352128
157MP0003329_amyloid_beta_deposits0.52177311
158MP0001727_abnormal_embryo_implantation0.51901932
159MP0005164_abnormal_response_to0.50983914
160MP0009703_decreased_birth_body0.50869300
161MP0005395_other_phenotype0.48569793
162MP0004087_abnormal_muscle_fiber0.47955369
163MP0002108_abnormal_muscle_morphology0.47788685
164MP0010352_gastrointestinal_tract_polyps0.46771051
165* MP0009642_abnormal_blood_homeostasis0.44047853
166MP0002069_abnormal_eating/drinking_beha0.40910369
167MP0001958_emphysema0.39576161
168MP0003091_abnormal_cell_migration0.38737864
169MP0006036_abnormal_mitochondrial_physio0.37885958
170MP0004782_abnormal_surfactant_physiolog0.37567958
171MP0008775_abnormal_heart_ventricle0.37445084
172MP0005388_respiratory_system_phenotype0.36820960
173MP0002133_abnormal_respiratory_system0.36820960
174MP0000647_abnormal_sebaceous_gland0.36487716
175MP0002896_abnormal_bone_mineralization0.34498010
176MP0002909_abnormal_adrenal_gland0.34429168
177MP0005167_abnormal_blood-brain_barrier0.34393325
178MP0002006_tumorigenesis0.33522477

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.23257592
2Complement deficiency (HP:0004431)5.01861001
3Oligomenorrhea (HP:0000876)4.97374429
4Acanthosis nigricans (HP:0000956)4.70361735
5Abnormality of serine family amino acid metabolism (HP:0010894)4.63630426
6Abnormality of glycine metabolism (HP:0010895)4.63630426
7Deep venous thrombosis (HP:0002625)4.45600710
8Epidermoid cyst (HP:0200040)4.44451331
9Hypertriglyceridemia (HP:0002155)4.38063291
10Xanthomatosis (HP:0000991)4.22315066
11Hypoalphalipoproteinemia (HP:0003233)4.07733925
12Hyperlipoproteinemia (HP:0010980)3.67785817
13Hyperglycinemia (HP:0002154)3.60747583
14Hypoglycemic coma (HP:0001325)3.58392869
15Abnormality of complement system (HP:0005339)3.56872846
16Hyperammonemia (HP:0001987)3.53734502
17Ketosis (HP:0001946)3.53534249
18Intrahepatic cholestasis (HP:0001406)3.37450403
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32628636
20Hypolipoproteinemia (HP:0010981)3.25972357
21Hydroxyprolinuria (HP:0003080)3.19002947
22Abnormality of proline metabolism (HP:0010907)3.19002947
23Insulin-resistant diabetes mellitus (HP:0000831)3.16750201
24Myocardial infarction (HP:0001658)3.14146624
25Hyperacusis (HP:0010780)3.12929203
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08132570
27Long foot (HP:0001833)3.07656544
28Abnormality of fatty-acid metabolism (HP:0004359)3.02983411
29Turricephaly (HP:0000262)2.98197851
30Ketoacidosis (HP:0001993)2.95604892
31Difficulty running (HP:0009046)2.93928417
32Myoglobinuria (HP:0002913)2.85298671
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84383310
34Hypercholesterolemia (HP:0003124)2.80506840
35Hemorrhage of the eye (HP:0011885)2.78932871
36Pigmentary retinal degeneration (HP:0001146)2.74382641
37Abnormality of the distal phalanx of the thumb (HP:0009617)2.70645740
38Dysmetric saccades (HP:0000641)2.69520410
39Skin nodule (HP:0200036)2.68821842
40Prolonged partial thromboplastin time (HP:0003645)2.68606432
41Sparse lateral eyebrow (HP:0005338)2.67723427
42Increased nuchal translucency (HP:0010880)2.56546941
43Subcapsular cataract (HP:0000523)2.53948706
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53758962
45Hypobetalipoproteinemia (HP:0003563)2.52299928
46Flat acetabular roof (HP:0003180)2.52156778
47Advanced eruption of teeth (HP:0006288)2.52040250
48Insulin resistance (HP:0000855)2.51322253
49Cerebral aneurysm (HP:0004944)2.51248600
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46107377
51Broad metatarsal (HP:0001783)2.41621918
52Septate vagina (HP:0001153)2.38203335
53Cortical dysplasia (HP:0002539)2.37205533
54Abnormality of the common coagulation pathway (HP:0010990)2.37113424
55Shallow orbits (HP:0000586)2.33417056
56Termporal pattern (HP:0011008)2.32392633
57Insidious onset (HP:0003587)2.32392633
58Dicarboxylic aciduria (HP:0003215)2.32146187
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32146187
60Increased connective tissue (HP:0009025)2.26641676
61Broad face (HP:0000283)2.26053821
62Hyperglycemia (HP:0003074)2.23666557
63Hepatoblastoma (HP:0002884)2.23218469
64Bronchomalacia (HP:0002780)2.21444466
65Enlarged penis (HP:0000040)2.20771968
66Abnormal cartilage morphology (HP:0002763)2.17891629
67Rhabdomyolysis (HP:0003201)2.17238940
68Bone cyst (HP:0012062)2.15173361
69Macroorchidism (HP:0000053)2.14719923
70Ankyloglossia (HP:0010296)2.14484398
71Systemic lupus erythematosus (HP:0002725)2.13301773
72Deviation of the thumb (HP:0009603)2.11544162
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.11523072
74Abnormality of purine metabolism (HP:0004352)2.11252856
75Insomnia (HP:0100785)2.11249072
76Abnormality of serum amino acid levels (HP:0003112)2.10414945
77Overgrowth (HP:0001548)2.09918240
78Growth hormone excess (HP:0000845)2.09270757
79Abnormality of the fingertips (HP:0001211)2.07634556
80Abnormality of the phalanges of the hallux (HP:0010057)2.07337110
81Pseudobulbar signs (HP:0002200)2.06971458
82Chromsome breakage (HP:0040012)2.05583033
83Hypoglycemic seizures (HP:0002173)2.05285736
84Spastic diplegia (HP:0001264)2.03165448
85Ankle contracture (HP:0006466)2.01064616
86Missing ribs (HP:0000921)2.00959926
87Germ cell neoplasia (HP:0100728)2.00527929
88Joint hemorrhage (HP:0005261)2.00416696
89Heterotopia (HP:0002282)2.00241841
90Mitral valve prolapse (HP:0001634)1.99914352
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97863879
92Relative macrocephaly (HP:0004482)1.97737050
93Clitoromegaly (HP:0000057)1.97238466
94Anal stenosis (HP:0002025)1.97159827
95Nephritis (HP:0000123)1.97037001
96Lymphangioma (HP:0100764)1.96190367
97Urethral obstruction (HP:0000796)1.95701999
98Abnormality of sulfur amino acid metabolism (HP:0004339)1.95453554
99Pancreatitis (HP:0001733)1.95067430
100Patellar dislocation (HP:0002999)1.94215734
101Overriding aorta (HP:0002623)1.92845229
102High anterior hairline (HP:0009890)1.92544168
103Limb hypertonia (HP:0002509)1.90269330
104Increased mean platelet volume (HP:0011877)1.88570924
105Ulnar bowing (HP:0003031)1.87206746
106Neonatal hypoglycemia (HP:0001998)1.86808261
107Hepatocellular carcinoma (HP:0001402)1.85631108
108Precocious puberty (HP:0000826)1.84021366
109Accelerated skeletal maturation (HP:0005616)1.83052578
110Hyperthyroidism (HP:0000836)1.83006568
111Elfin facies (HP:0004428)1.82940650
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82843525
113Obsessive-compulsive behavior (HP:0000722)1.82226583
114Bifid scrotum (HP:0000048)1.80909288
115Large hands (HP:0001176)1.80842550
116Abnormal ossification of hand bones (HP:0005921)1.80601580
117Cerebral inclusion bodies (HP:0100314)1.80067886
118Tetraparesis (HP:0002273)1.79783828
119Abnormality of carpal bone ossification (HP:0006257)1.79045265
120Proximal placement of thumb (HP:0009623)1.77798740
12111 pairs of ribs (HP:0000878)1.75041209
122Abnormality of the intrinsic pathway (HP:0010989)1.74715423
123Selective tooth agenesis (HP:0001592)1.74261670
124Right ventricular cardiomyopathy (HP:0011663)1.73930927
125Duplication of thumb phalanx (HP:0009942)1.72636365
126Sandal gap (HP:0001852)1.72531223
127Deep philtrum (HP:0002002)1.72432222
128Midface retrusion (HP:0011800)1.72155021
129Vertebral arch anomaly (HP:0008438)1.70702017
130Short nail (HP:0001799)1.70656511
131Disproportionate tall stature (HP:0001519)1.70511940
132Asymmetry of the thorax (HP:0001555)1.70349451
133Choanal stenosis (HP:0000452)1.70176598
134Glossoptosis (HP:0000162)1.70131129
135Natal tooth (HP:0000695)1.69390839
136Overlapping toe (HP:0001845)1.69197998
137Long eyelashes (HP:0000527)1.69029984
138Back pain (HP:0003418)1.68587378
139Aneurysm (HP:0002617)1.67763802
140Abnormality of nucleobase metabolism (HP:0010932)1.67514719
141Abnormal tarsal ossification (HP:0008369)1.67249088
142Prenatal maternal abnormality (HP:0002686)1.67039563
143Short 1st metacarpal (HP:0010034)1.66828675
144Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.66828675
145Reduced subcutaneous adipose tissue (HP:0003758)1.66723810
146Abnormality of the 4th metacarpal (HP:0010012)1.66689518
147Renal duplication (HP:0000075)1.66389527
148Esophageal varix (HP:0002040)1.66271347
149Renovascular hypertension (HP:0100817)1.65827299
150Abnormality of methionine metabolism (HP:0010901)1.64711224
151Partial agenesis of the corpus callosum (HP:0001338)1.62107973
152Mitral stenosis (HP:0001718)1.60945882
153Striae distensae (HP:0001065)1.60932856
154Obstructive sleep apnea (HP:0002870)1.60498689
155Abnormality of the 1st metacarpal (HP:0010009)1.60055158
156Abnormality of oral frenula (HP:0000190)1.59881847
157Protrusio acetabuli (HP:0003179)1.59825871
158Aortic aneurysm (HP:0004942)1.59395217
159Abnormality of the parathyroid morphology (HP:0011766)1.59041365
160Long palpebral fissure (HP:0000637)1.58879633
161Smooth philtrum (HP:0000319)1.58873239
162Polar cataract (HP:0010696)1.58663114
163Aplasia involving bones of the upper limbs (HP:0009823)1.57888843
164Aplasia of the phalanges of the hand (HP:0009802)1.57888843
165Aplasia involving bones of the extremities (HP:0009825)1.57888843
166Amyloidosis (HP:0011034)1.57788262
167Abnormal hand bone ossification (HP:0010660)1.57553929
168Abnormality of the astrocytes (HP:0100707)1.57542623
169Astrocytoma (HP:0009592)1.57542623
170Peritonitis (HP:0002586)1.57265660
171Abnormal foot bone ossification (HP:0010675)1.57103567
172Upper motor neuron abnormality (HP:0002127)1.56140047
173Generalized hypotonia (HP:0001290)1.55316628
174Laryngomalacia (HP:0001601)1.55265867
175Abnormality of the salivary glands (HP:0010286)1.53717496
176Hammertoe (HP:0001765)1.53385881
177Neoplasm of the adrenal cortex (HP:0100641)1.52463111
178Abnormality of chromosome segregation (HP:0002916)1.52422417
179Tracheal stenosis (HP:0002777)1.52185662
180Attention deficit hyperactivity disorder (HP:0007018)1.51680309
181Preauricular skin tag (HP:0000384)1.51463646
182Arnold-Chiari malformation (HP:0002308)1.51313581
183Hypospadias (HP:0000047)1.50978550
184Short phalanx of the thumb (HP:0009660)1.49030973
185Abnormality of the distal phalanges of the toes (HP:0010182)1.48148862
186Lip pit (HP:0100267)1.47393373
187Skin tags (HP:0010609)1.47379147
188Broad thumb (HP:0011304)1.46773542
189Cubitus valgus (HP:0002967)1.46728702
190Hypopigmentation of the fundus (HP:0007894)1.46244384
191Narrow palate (HP:0000189)1.45905825
192Spina bifida occulta (HP:0003298)1.44937291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.99967267
2TRIB35.09565925
3BCKDK3.40715946
4SMG12.79634250
5RIPK12.67520357
6PDK42.60633536
7PDK32.60633536
8PKN22.57094394
9LATS12.41639828
10MST1R2.38198340
11FGFR22.37278670
12AKT32.25359719
13INSRR2.16780817
14TTK1.88497749
15PNCK1.79111737
16EPHA21.75659861
17ERN11.67107116
18TSSK61.66991562
19PDGFRA1.65186340
20FRK1.64973992
21EEF2K1.60370659
22FGFR41.57258257
23CDK121.56920733
24BRD41.55211340
25CDC71.50063813
26MET1.48248619
27CDK61.48111645
28FGFR31.47039058
29TAOK11.42996471
30DDR21.40751197
31LMTK21.40679091
32MTOR1.38805286
33PDK21.33467885
34* PRKAA21.32997238
35CDK91.31121441
36PTK61.30693486
37ICK1.30622542
38MAP3K91.24934341
39RET1.24225076
40LATS21.20843739
41IRAK31.18781629
42CDK71.17136043
43PRKD31.16538408
44PIK3CA1.15566906
45BMX1.13026359
46SRPK11.12709329
47PDGFRB1.10656250
48TAF11.09572819
49DAPK21.09525543
50JAK11.08126711
51EIF2AK11.00848159
52RPS6KB20.99285254
53STK390.94098970
54* CAMK1G0.93101182
55FGFR10.92733151
56* CAMK1D0.91568034
57TTN0.91143864
58MAP3K60.89594768
59CHEK20.88991666
60EPHB20.87535298
61CHEK10.87528737
62PRKD20.87012084
63PBK0.86859484
64MAPK110.86380248
65GSK3A0.86081648
66PRKCH0.85367176
67PDPK10.84795726
68MAP3K70.82236172
69* PRKAA10.80507320
70PRKCI0.80164322
71MAP2K40.79662630
72STK30.78958446
73BRSK20.77856923
74JAK20.77619219
75ATR0.77315612
76EPHB10.76128962
77ERBB40.74530345
78PAK40.74434260
79PAK20.73613900
80CDK10.73606568
81PDK10.70786646
82TYRO30.70661950
83FER0.70539512
84PAK60.70405299
85WNK40.68848858
86CDK40.68828261
87MKNK10.67933778
88CSNK1E0.67777399
89ATM0.67084454
90IGF1R0.66692078
91AURKB0.66054934
92BRSK10.65883242
93MKNK20.64273976
94SGK30.64066900
95CDK20.63510329
96MARK20.60693733
97NEK20.59498615
98FLT30.58059355
99WEE10.57846701
100BRAF0.57224588
101MAP2K10.57030134
102MAPK100.56803964
103* PRKACG0.55966197
104GSK3B0.55422507
105CASK0.54458977
106ERBB20.53040472
107NEK10.52598357
108* PRKDC0.52156357
109TGFBR20.51685957
110NEK90.51648159
111INSR0.51589612
112PRKD10.51410404
113PHKG10.51134459
114PHKG20.51134459
115PRKCZ0.50012705
116RPS6KB10.49309312
117RAF10.49259443
118AURKA0.48796408
119MAPK140.48638793
120IRAK20.48400801
121CSF1R0.47595754
122MAP3K80.47587930
123SCYL20.47570581
124STK110.47567477
125KSR10.47073601
126PLK30.45670285
127ARAF0.44259631
128MINK10.43698891
129MAP3K100.43623229
130PKN10.43174172
131STK38L0.42197544
132AKT20.42086578
133EIF2AK20.42008283
134NTRK10.41469030
135CSNK1G10.41344217
136SRC0.41016655
137PLK10.40971824
138PTK20.39445077
139EPHA30.39317018
140MAP3K20.39012829
141PIM20.38481072
142KSR20.38181150
143SGK2230.37069526
144SGK4940.37069526
145RPS6KA30.36453910
146MAP3K40.34543030
147AKT10.34141814
148STK380.33867928
149CSNK1D0.33709581
150MAPK120.33592682
151MARK10.32622646
152ALK0.32551868
153WNK10.31403952
154CSNK1A1L0.30680879
155SIK20.30427370
156SGK10.28100665

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fatty acid biosynthesis_Homo sapiens_hsa000614.12675431
2PPAR signaling pathway_Homo sapiens_hsa033203.54280341
3* Propanoate metabolism_Homo sapiens_hsa006403.45538666
4Nitrogen metabolism_Homo sapiens_hsa009103.35687524
5* Fatty acid metabolism_Homo sapiens_hsa012123.31770156
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.13997281
7Fatty acid degradation_Homo sapiens_hsa000713.03687987
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61430200
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.48148717
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.39153483
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33289631
12Caffeine metabolism_Homo sapiens_hsa002322.24413689
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23015334
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20926747
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14264199
16Glycerolipid metabolism_Homo sapiens_hsa005612.09769830
17Butanoate metabolism_Homo sapiens_hsa006501.98224966
18* Pyruvate metabolism_Homo sapiens_hsa006201.90161037
19Arginine biosynthesis_Homo sapiens_hsa002201.88738801
20beta-Alanine metabolism_Homo sapiens_hsa004101.82963841
21Tryptophan metabolism_Homo sapiens_hsa003801.81405908
22Complement and coagulation cascades_Homo sapiens_hsa046101.72827563
23Fatty acid elongation_Homo sapiens_hsa000621.68014162
24Peroxisome_Homo sapiens_hsa041461.64582197
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59665516
26Carbon metabolism_Homo sapiens_hsa012001.57983349
27Fat digestion and absorption_Homo sapiens_hsa049751.56313621
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54655509
29Thyroid cancer_Homo sapiens_hsa052161.52415016
30Non-homologous end-joining_Homo sapiens_hsa034501.50639947
31Staphylococcus aureus infection_Homo sapiens_hsa051501.48869098
32DNA replication_Homo sapiens_hsa030301.46992520
33Cell cycle_Homo sapiens_hsa041101.43941104
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.41920766
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39909594
36mRNA surveillance pathway_Homo sapiens_hsa030151.38040789
37* AMPK signaling pathway_Homo sapiens_hsa041521.36015322
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32940218
39Lysine degradation_Homo sapiens_hsa003101.29297716
40Prostate cancer_Homo sapiens_hsa052151.28656473
41MicroRNAs in cancer_Homo sapiens_hsa052061.27543246
42RNA transport_Homo sapiens_hsa030131.24773195
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21685451
44Hippo signaling pathway_Homo sapiens_hsa043901.19849549
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18343744
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16903436
47Insulin resistance_Homo sapiens_hsa049311.13601195
48Tyrosine metabolism_Homo sapiens_hsa003501.13177163
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11492938
50Phenylalanine metabolism_Homo sapiens_hsa003601.11350686
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08688037
52ErbB signaling pathway_Homo sapiens_hsa040121.08185205
53ABC transporters_Homo sapiens_hsa020101.06501582
54Tight junction_Homo sapiens_hsa045301.06019505
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05476749
56Mismatch repair_Homo sapiens_hsa034300.99161399
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98726068
58Vitamin B6 metabolism_Homo sapiens_hsa007500.96209082
59Bile secretion_Homo sapiens_hsa049760.91954180
60Biosynthesis of amino acids_Homo sapiens_hsa012300.91848854
61Glioma_Homo sapiens_hsa052140.91086790
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90537059
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90085635
64Notch signaling pathway_Homo sapiens_hsa043300.89254474
65Axon guidance_Homo sapiens_hsa043600.89243870
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88609995
67* Insulin signaling pathway_Homo sapiens_hsa049100.85677046
68Colorectal cancer_Homo sapiens_hsa052100.85514469
69Starch and sucrose metabolism_Homo sapiens_hsa005000.84415765
70Retinol metabolism_Homo sapiens_hsa008300.82331686
71Wnt signaling pathway_Homo sapiens_hsa043100.81606180
72Estrogen signaling pathway_Homo sapiens_hsa049150.80837340
73Nucleotide excision repair_Homo sapiens_hsa034200.80563877
74Oocyte meiosis_Homo sapiens_hsa041140.79681287
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79228173
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78455614
77Steroid biosynthesis_Homo sapiens_hsa001000.76662194
78Chemical carcinogenesis_Homo sapiens_hsa052040.76641519
79Hedgehog signaling pathway_Homo sapiens_hsa043400.75662230
80Melanogenesis_Homo sapiens_hsa049160.75190290
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.75079678
82Non-small cell lung cancer_Homo sapiens_hsa052230.74705374
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74577368
84Long-term potentiation_Homo sapiens_hsa047200.73821034
85Pentose phosphate pathway_Homo sapiens_hsa000300.73407677
86Bladder cancer_Homo sapiens_hsa052190.72664237
87Histidine metabolism_Homo sapiens_hsa003400.71899736
88* Glucagon signaling pathway_Homo sapiens_hsa049220.71711917
89Spliceosome_Homo sapiens_hsa030400.70744275
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69987767
91N-Glycan biosynthesis_Homo sapiens_hsa005100.69913706
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69151639
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67181399
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66895788
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66755520
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.66488748
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66472026
98Renin-angiotensin system_Homo sapiens_hsa046140.65881143
99Gap junction_Homo sapiens_hsa045400.64390755
100Renal cell carcinoma_Homo sapiens_hsa052110.64071753
101Choline metabolism in cancer_Homo sapiens_hsa052310.63779369
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63704876
103Selenocompound metabolism_Homo sapiens_hsa004500.62291648
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61305921
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.60423797
106Melanoma_Homo sapiens_hsa052180.60314724
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.59411921
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59316383
109Type II diabetes mellitus_Homo sapiens_hsa049300.56077602
110VEGF signaling pathway_Homo sapiens_hsa043700.55701796
111Pancreatic cancer_Homo sapiens_hsa052120.54927174
112Base excision repair_Homo sapiens_hsa034100.53958750
113Long-term depression_Homo sapiens_hsa047300.52954110
114Pathways in cancer_Homo sapiens_hsa052000.52816798
115ECM-receptor interaction_Homo sapiens_hsa045120.49595093
116Fanconi anemia pathway_Homo sapiens_hsa034600.48860342
117TGF-beta signaling pathway_Homo sapiens_hsa043500.47189607
118mTOR signaling pathway_Homo sapiens_hsa041500.39819189
119Sulfur metabolism_Homo sapiens_hsa009200.37058508
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36222153
121Renin secretion_Homo sapiens_hsa049240.31222132
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31042357
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.30706507
124Vitamin digestion and absorption_Homo sapiens_hsa049770.29656412
125Focal adhesion_Homo sapiens_hsa045100.28758429
126Amoebiasis_Homo sapiens_hsa051460.21165965
127Protein digestion and absorption_Homo sapiens_hsa049740.18990338
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18645207
129Proteoglycans in cancer_Homo sapiens_hsa052050.16964406
130Small cell lung cancer_Homo sapiens_hsa052220.15549807
131Adherens junction_Homo sapiens_hsa045200.15318697
132Dorso-ventral axis formation_Homo sapiens_hsa043200.15213082
133Prion diseases_Homo sapiens_hsa050200.14399295
134Sulfur relay system_Homo sapiens_hsa041220.14198311
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14175750
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13573631
137Ovarian steroidogenesis_Homo sapiens_hsa049130.12721510
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11753627
139Galactose metabolism_Homo sapiens_hsa000520.11471568
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10926394
141* Metabolic pathways_Homo sapiens_hsa011000.10710444
142Acute myeloid leukemia_Homo sapiens_hsa052210.10470659
143Endometrial cancer_Homo sapiens_hsa052130.09758941
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09296636
145Basal cell carcinoma_Homo sapiens_hsa052170.08179297
146Linoleic acid metabolism_Homo sapiens_hsa005910.07322968
147Arginine and proline metabolism_Homo sapiens_hsa003300.04869061
148Fructose and mannose metabolism_Homo sapiens_hsa000510.04383869
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03519282
150Prolactin signaling pathway_Homo sapiens_hsa049170.02846676
151One carbon pool by folate_Homo sapiens_hsa006700.02277359
152Thyroid hormone synthesis_Homo sapiens_hsa049180.02145800
153Chronic myeloid leukemia_Homo sapiens_hsa052200.01797106

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »