ABRACL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04098343
2ATP synthesis coupled proton transport (GO:0015986)5.20065013
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20065013
4proteasome assembly (GO:0043248)5.10334618
5protein neddylation (GO:0045116)4.74340024
6ribosomal small subunit assembly (GO:0000028)4.69835172
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.64110532
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49890865
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.45651716
10chaperone-mediated protein transport (GO:0072321)4.41230541
11establishment of integrated proviral latency (GO:0075713)4.20921779
12chromatin remodeling at centromere (GO:0031055)4.09562028
13neutrophil activation involved in immune response (GO:0002283)4.09471810
14respiratory electron transport chain (GO:0022904)4.07989632
15CENP-A containing nucleosome assembly (GO:0034080)4.05346671
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05196037
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03877334
18negative regulation of ligase activity (GO:0051352)4.02419231
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.02419231
20electron transport chain (GO:0022900)3.98835435
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.96447914
22viral transcription (GO:0019083)3.90128149
23rRNA modification (GO:0000154)3.87884818
24termination of RNA polymerase III transcription (GO:0006386)3.84740911
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.84740911
26regulation of cellular amino acid metabolic process (GO:0006521)3.82722581
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80797303
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80724365
29translational termination (GO:0006415)3.78588011
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74153348
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69758207
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69253736
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69253736
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69253736
35respiratory chain complex IV assembly (GO:0008535)3.69070143
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65379837
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65379837
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64783570
39protein complex biogenesis (GO:0070271)3.64247504
40cotranslational protein targeting to membrane (GO:0006613)3.59250772
41protein targeting to ER (GO:0045047)3.58988918
42ribosomal small subunit biogenesis (GO:0042274)3.57640249
43purine nucleobase biosynthetic process (GO:0009113)3.57590129
44mitochondrial respiratory chain complex assembly (GO:0033108)3.56574782
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.52778387
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.52778387
47cytochrome complex assembly (GO:0017004)3.52038758
48regulation of mitotic spindle checkpoint (GO:1903504)3.49249898
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49249898
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.48888094
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46861255
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46861255
53pseudouridine synthesis (GO:0001522)3.40501325
54establishment of viral latency (GO:0019043)3.40260544
55cellular response to interferon-beta (GO:0035458)3.40198504
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40075572
57histone exchange (GO:0043486)3.39789748
58DNA damage response, detection of DNA damage (GO:0042769)3.39279637
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38353433
60protein localization to endoplasmic reticulum (GO:0070972)3.35893770
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32636678
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32636678
63sequestering of actin monomers (GO:0042989)3.30461381
64nucleobase biosynthetic process (GO:0046112)3.29047009
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28540442
66response to peptidoglycan (GO:0032494)3.28393523
67rRNA methylation (GO:0031167)3.27976070
68antigen processing and presentation of endogenous antigen (GO:0019883)3.27915586
69DNA double-strand break processing (GO:0000729)3.25259107
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25085497
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.25085497
72NADH dehydrogenase complex assembly (GO:0010257)3.25085497
73spliceosomal snRNP assembly (GO:0000387)3.22249577
74cellular response to zinc ion (GO:0071294)3.21941403
75translational elongation (GO:0006414)3.21122196
76respiratory burst (GO:0045730)3.20932868
77leukocyte aggregation (GO:0070486)3.19966563
78response to interferon-beta (GO:0035456)3.18369430
79positive regulation of ligase activity (GO:0051351)3.16043173
80histone mRNA metabolic process (GO:0008334)3.15065521
81immunoglobulin mediated immune response (GO:0016064)3.13857826
82DNA replication-independent nucleosome assembly (GO:0006336)3.10518868
83DNA replication-independent nucleosome organization (GO:0034724)3.10518868
84positive regulation of interferon-alpha production (GO:0032727)3.10085269
85regulation of helicase activity (GO:0051095)3.07619690
86viral life cycle (GO:0019058)3.06883652
87DNA catabolic process, exonucleolytic (GO:0000738)3.06434272
88rRNA processing (GO:0006364)3.06305773
89oxidative phosphorylation (GO:0006119)3.03599605
90positive regulation of chemokine biosynthetic process (GO:0045080)3.03208800
91ribosome assembly (GO:0042255)3.02991127
92protein targeting to mitochondrion (GO:0006626)3.02199510
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01462014
94DNA replication checkpoint (GO:0000076)2.98420861
95regulation of ubiquitin-protein transferase activity (GO:0051438)2.97546989
96rRNA metabolic process (GO:0016072)2.97282947
97DNA ligation (GO:0006266)2.95973125
98cellular component biogenesis (GO:0044085)2.95938714
99regulation of interferon-alpha production (GO:0032647)2.95310674
100neutrophil activation (GO:0042119)2.93756683
101cellular protein complex disassembly (GO:0043624)2.91811212
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90262934
103ribonucleoprotein complex biogenesis (GO:0022613)2.89719863
104granulocyte activation (GO:0036230)2.89551507
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88755559
106regulation of ligase activity (GO:0051340)2.88366762
107signal peptide processing (GO:0006465)2.87460628
108cullin deneddylation (GO:0010388)2.86960893
109regulation of mitochondrial translation (GO:0070129)2.86607677
110negative regulation of protein ubiquitination (GO:0031397)2.86232137
111type I interferon signaling pathway (GO:0060337)2.84367462
112cellular response to type I interferon (GO:0071357)2.84367462
113regulation of chemokine biosynthetic process (GO:0045073)2.84054159
114establishment of protein localization to mitochondrion (GO:0072655)2.83450033
115formation of translation preinitiation complex (GO:0001731)2.82749315
116IMP biosynthetic process (GO:0006188)2.82525543
117response to type I interferon (GO:0034340)2.82514883
118maturation of SSU-rRNA (GO:0030490)2.80297558
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80256471
120T cell migration (GO:0072678)2.80241312
121positive regulation of gamma-delta T cell activation (GO:0046645)2.79615465
122B cell mediated immunity (GO:0019724)2.77577114
123translational initiation (GO:0006413)2.76730632
124myeloid dendritic cell activation (GO:0001773)2.75754594
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70350950
126natural killer cell mediated cytotoxicity (GO:0042267)2.68759193
127natural killer cell mediated immunity (GO:0002228)2.68759193
128regulation of B cell receptor signaling pathway (GO:0050855)2.68049358
129negative regulation of phagocytosis (GO:0050765)2.66333495
130ribosomal large subunit biogenesis (GO:0042273)2.63594862
131defense response to protozoan (GO:0042832)2.63244296
132telomere maintenance via semi-conservative replication (GO:0032201)2.60730938
133positive regulation by symbiont of host defense response (GO:0052509)2.60284848
134modulation by symbiont of host defense response (GO:0052031)2.60284848
135modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60284848
136modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60284848
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.60284848
138modulation by symbiont of host immune response (GO:0052553)2.60284848
139interferon-gamma-mediated signaling pathway (GO:0060333)2.57026307
140NIK/NF-kappaB signaling (GO:0038061)2.56843355
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56091534
142regulation of T-helper 1 cell differentiation (GO:0045625)2.55449897
143production of molecular mediator involved in inflammatory response (GO:0002532)2.54654345
144regulation of vitamin D biosynthetic process (GO:0060556)2.54012259
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53962650
146negative regulation of viral genome replication (GO:0045071)2.53910626
147response to protozoan (GO:0001562)2.53760294
148mast cell activation (GO:0045576)2.53295183
149reactive oxygen species biosynthetic process (GO:1903409)2.52433266
150interferon-gamma production (GO:0032609)2.51849771
151telomere maintenance via recombination (GO:0000722)2.51673104
152actin nucleation (GO:0045010)2.50157020
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.49844051
154hydrogen peroxide biosynthetic process (GO:0050665)2.49764013
155positive regulation of isotype switching (GO:0045830)2.49267561
156antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49046507
157protein complex disassembly (GO:0043241)2.48796592
158positive regulation of macrophage differentiation (GO:0045651)2.46723846
159regulation of interleukin-12 biosynthetic process (GO:0045075)2.44106812
160superoxide anion generation (GO:0042554)2.44004193
161regulation of alpha-beta T cell proliferation (GO:0046640)2.40757916
162response to interferon-alpha (GO:0035455)2.39903186
163positive regulation of interferon-beta production (GO:0032728)2.39525997
164cellular response to exogenous dsRNA (GO:0071360)2.39215714
165DNA deamination (GO:0045006)2.39151391
166protein targeting to membrane (GO:0006612)2.39078384
167myeloid dendritic cell differentiation (GO:0043011)2.39061790
168regulation of B cell differentiation (GO:0045577)2.37615086
169myeloid cell activation involved in immune response (GO:0002275)2.35300354
170response to muramyl dipeptide (GO:0032495)2.34826608
171regulation of protein heterodimerization activity (GO:0043497)2.34747796
172translation (GO:0006412)2.34467741
173DNA strand elongation involved in DNA replication (GO:0006271)2.34366358
174macromolecular complex disassembly (GO:0032984)2.33973096
175mitotic recombination (GO:0006312)2.31876490
176positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29995029
177negative regulation of myeloid cell apoptotic process (GO:0033033)2.29560495
178leukocyte degranulation (GO:0043299)2.28855325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38325558
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.45636421
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.91785671
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.57885408
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55797919
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29280776
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11724763
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84416686
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83683479
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82478799
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72997584
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.70980553
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.70558833
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60517521
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57901334
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.57453072
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47251847
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.41881039
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38583199
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37958347
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27525455
22ELK1_19687146_ChIP-ChIP_HELA_Human2.24923272
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21503165
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20290245
25* SPI1_23547873_ChIP-Seq_NB4_Human2.18390156
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14168111
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.11695131
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07884401
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.07826829
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07575463
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04207839
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03525622
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01554948
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01136718
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98624757
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92784118
37VDR_23849224_ChIP-Seq_CD4+_Human1.92500034
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85254548
39MYB_26560356_Chip-Seq_TH2_Human1.84951540
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84638786
41MYC_18940864_ChIP-ChIP_HL60_Human1.80347317
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79457861
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77369513
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74731667
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70672414
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.70641363
47DCP1A_22483619_ChIP-Seq_HELA_Human1.69559440
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68960065
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64715165
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62759412
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62316398
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61106570
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.60915561
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60444244
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.59688166
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58625987
57XRN2_22483619_ChIP-Seq_HELA_Human1.57133450
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.55920242
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55466671
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55234590
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53194029
62FOXP3_21729870_ChIP-Seq_TREG_Human1.52848933
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52454084
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45726689
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45593964
66MYB_26560356_Chip-Seq_TH1_Human1.43824923
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43540002
68MAF_26560356_Chip-Seq_TH1_Human1.42867533
69EWS_26573619_Chip-Seq_HEK293_Human1.42670519
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42272158
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41198722
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40724263
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38647591
74VDR_22108803_ChIP-Seq_LS180_Human1.38297682
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.37426697
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36033555
77VDR_24763502_ChIP-Seq_THP-1_Human1.35448059
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34055267
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33854793
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33083378
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31894697
82TTF2_22483619_ChIP-Seq_HELA_Human1.31349444
83VDR_21846776_ChIP-Seq_THP-1_Human1.31092776
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.29669625
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29601440
86MYC_22102868_ChIP-Seq_BL_Human1.28570836
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26096667
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.25963272
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25150753
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23690407
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22293513
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.21871628
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21731848
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.21670814
95UTX_26944678_Chip-Seq_JUKART_Human1.21287170
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.20690593
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19924164
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18071909
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17375719
100TFEB_21752829_ChIP-Seq_HELA_Human1.16785689
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16386437
102GABP_19822575_ChIP-Seq_HepG2_Human1.15661864
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14607696
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14602641
105ZNF274_21170338_ChIP-Seq_K562_Hela1.14033786
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13166878
107SOX2_16153702_ChIP-ChIP_HESCs_Human1.12609575
108SCL_19346495_ChIP-Seq_HPC-7_Human1.12172517
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11132241
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10035171
111PU_27001747_Chip-Seq_BMDM_Mouse1.09380779
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06964806
113FUS_26573619_Chip-Seq_HEK293_Human1.05111702
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04165461
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02472219
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01799144
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00977539
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99538499
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98994287
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96239151
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95661260
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95007761
123RUNX_20019798_ChIP-Seq_JUKART_Human0.93601591
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92870853
125IRF1_19129219_ChIP-ChIP_H3396_Human0.91663347
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90408411
127GATA3_27048872_Chip-Seq_THYMUS_Human0.90196383
128MAF_26560356_Chip-Seq_TH2_Human0.89558294
129GATA1_22025678_ChIP-Seq_K562_Human0.87943417
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87676967
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87137939
132IGF1R_20145208_ChIP-Seq_DFB_Human0.86973982
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86237577
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84613015
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84443530
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82843782
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.81771349
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81620355
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80195134
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.80180552
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.78174935
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78174935
143KDM5A_27292631_Chip-Seq_BREAST_Human0.78163087
144GATA3_26560356_Chip-Seq_TH2_Human0.78100269
145P300_19829295_ChIP-Seq_ESCs_Human0.75730264
146ELF5_23300383_ChIP-Seq_T47D_Human0.74667625
147ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74413206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.17166068
2MP0009785_altered_susceptibility_to3.58000097
3MP0003436_decreased_susceptibility_to3.43616246
4MP0002148_abnormal_hypersensitivity_rea3.29102932
5MP0005671_abnormal_response_to2.98256962
6MP0003806_abnormal_nucleotide_metabolis2.98098198
7MP0005000_abnormal_immune_tolerance2.95876112
8MP0005025_abnormal_response_to2.66431912
9MP0003724_increased_susceptibility_to2.60121917
10MP0000685_abnormal_immune_system2.57458590
11MP0008877_abnormal_DNA_methylation2.53269310
12MP0002452_abnormal_antigen_presenting2.51246470
13MP0002419_abnormal_innate_immunity2.50700504
14MP0001800_abnormal_humoral_immune2.44163057
15MP0003941_abnormal_skin_development2.43564115
16MP0002102_abnormal_ear_morphology2.42928037
17MP0002006_tumorigenesis2.41116559
18MP0001790_abnormal_immune_system2.41011072
19MP0005387_immune_system_phenotype2.41011072
20MP0002723_abnormal_immune_serum2.36558573
21MP0001819_abnormal_immune_cell2.34107817
22MP0002420_abnormal_adaptive_immunity2.33904649
23MP0006292_abnormal_olfactory_placode2.32444032
24MP0003763_abnormal_thymus_physiology2.25176833
25MP0006082_CNS_inflammation2.21333941
26MP0005075_abnormal_melanosome_morpholog2.19373816
27MP0003718_maternal_effect2.19372962
28MP0002166_altered_tumor_susceptibility2.18094551
29MP0002254_reproductive_system_inflammat2.11961311
30MP0009333_abnormal_splenocyte_physiolog2.04976356
31MP0000858_altered_metastatic_potential2.01445916
32MP0002398_abnormal_bone_marrow1.99878144
33MP0002405_respiratory_system_inflammati1.98912649
34MP0001853_heart_inflammation1.85041860
35MP0003693_abnormal_embryo_hatching1.83801287
36MP0000716_abnormal_immune_system1.83493580
37MP0001188_hyperpigmentation1.80063666
38MP0010155_abnormal_intestine_physiology1.78847759
39MP0006072_abnormal_retinal_apoptosis1.77683441
40MP0006036_abnormal_mitochondrial_physio1.77030302
41MP0001533_abnormal_skeleton_physiology1.74223713
42MP0009697_abnormal_copulation1.72973541
43MP0005464_abnormal_platelet_physiology1.71920114
44MP0001845_abnormal_inflammatory_respons1.69760123
45MP0003303_peritoneal_inflammation1.68360959
46MP0006054_spinal_hemorrhage1.64345121
47MP0010352_gastrointestinal_tract_polyps1.63601786
48MP0000490_abnormal_crypts_of1.61626443
49MP0004947_skin_inflammation1.61263540
50MP0002396_abnormal_hematopoietic_system1.60695822
51MP0002429_abnormal_blood_cell1.60115895
52MP0002722_abnormal_immune_system1.58617340
53MP0004808_abnormal_hematopoietic_stem1.57720558
54MP0000689_abnormal_spleen_morphology1.54836079
55MP0003448_altered_tumor_morphology1.54779359
56MP0005084_abnormal_gallbladder_morpholo1.49974259
57MP0006035_abnormal_mitochondrial_morpho1.47343133
58MP0001293_anophthalmia1.45568985
59MP0008995_early_reproductive_senescence1.43713367
60MP0008007_abnormal_cellular_replicative1.41586401
61MP0004510_myositis1.41421295
62MP0004957_abnormal_blastocyst_morpholog1.40736199
63MP0000343_altered_response_to1.38403041
64MP0003195_calcinosis1.34098612
65MP0003077_abnormal_cell_cycle1.33238378
66MP0001545_abnormal_hematopoietic_system1.32514223
67MP0005397_hematopoietic_system_phenotyp1.32514223
68MP0008469_abnormal_protein_level1.30355172
69MP0003186_abnormal_redox_activity1.29627398
70MP0010094_abnormal_chromosome_stability1.29560359
71MP0002138_abnormal_hepatobiliary_system1.29057271
72MP0000703_abnormal_thymus_morphology1.28928729
73MP0003567_abnormal_fetal_cardiomyocyte1.27771741
74MP0009764_decreased_sensitivity_to1.26047580
75MP0002736_abnormal_nociception_after1.19237998
76MP0002933_joint_inflammation1.17668803
77MP0002877_abnormal_melanocyte_morpholog1.14974037
78MP0009379_abnormal_foot_pigmentation1.14946556
79MP0003011_delayed_dark_adaptation1.13477569
80MP0003828_pulmonary_edema1.11782006
81MP0010307_abnormal_tumor_latency1.09924914
82MP0003787_abnormal_imprinting1.09505155
83MP0002019_abnormal_tumor_incidence1.07640620
84MP0008057_abnormal_DNA_replication1.06802069
85MP0002938_white_spotting1.06566748
86MP0004147_increased_porphyrin_level1.06545296
87MP0001485_abnormal_pinna_reflex1.06526494
88MP0005174_abnormal_tail_pigmentation1.05486320
89MP0001529_abnormal_vocalization1.02945414
90MP0001873_stomach_inflammation1.02312897
91MP0002998_abnormal_bone_remodeling1.01708258
92MP0000465_gastrointestinal_hemorrhage1.01073933
93MP0008872_abnormal_physiological_respon1.00871180
94MP0002132_abnormal_respiratory_system1.00116213
95MP0005390_skeleton_phenotype0.99292973
96MP0001919_abnormal_reproductive_system0.97701908
97MP0001764_abnormal_homeostasis0.96770809
98MP0005058_abnormal_lysosome_morphology0.95624071
99MP0008438_abnormal_cutaneous_collagen0.94039858
100MP0005023_abnormal_wound_healing0.91474671
101MP0005377_hearing/vestibular/ear_phenot0.88700998
102MP0003878_abnormal_ear_physiology0.88700998
103MP0005389_reproductive_system_phenotype0.88451577
104MP0002277_abnormal_respiratory_mucosa0.87699334
105MP0008058_abnormal_DNA_repair0.86638955
106MP0002751_abnormal_autonomic_nervous0.86228432
107MP0002009_preneoplasia0.86062327
108MP0005310_abnormal_salivary_gland0.86022880
109MP0009278_abnormal_bone_marrow0.85705748
110MP0003866_abnormal_defecation0.84909343
111MP0003566_abnormal_cell_adhesion0.84466573
112MP0008789_abnormal_olfactory_epithelium0.84075436
113MP0003111_abnormal_nucleus_morphology0.83308278
114MP0004782_abnormal_surfactant_physiolog0.82863218
115MP0003890_abnormal_embryonic-extraembry0.81805118
116MP0005076_abnormal_cell_differentiation0.81483485
117MP0005645_abnormal_hypothalamus_physiol0.81167561
118MP0001727_abnormal_embryo_implantation0.80443336
119MP0001730_embryonic_growth_arrest0.80130708
120MP0003795_abnormal_bone_structure0.79629025
121MP0003121_genomic_imprinting0.79362230
122MP0003300_gastrointestinal_ulcer0.78789944
123MP0003279_aneurysm0.78535592
124MP0000313_abnormal_cell_death0.77409772
125MP0002210_abnormal_sex_determination0.75078996
126MP0008873_increased_physiological_sensi0.74429881
127MP0001145_abnormal_male_reproductive0.73853215
128MP0002163_abnormal_gland_morphology0.73490266
129MP0008875_abnormal_xenobiotic_pharmacok0.73454140
130MP0005164_abnormal_response_to0.73411666
131MP0002837_dystrophic_cardiac_calcinosis0.73379999
132MP0002090_abnormal_vision0.72692236
133MP0005410_abnormal_fertilization0.72371926
134MP0009763_increased_sensitivity_to0.70804806
135MP0003786_premature_aging0.69024321
136MP0002693_abnormal_pancreas_physiology0.65818095
137MP0001243_abnormal_dermal_layer0.64868029
138MP0002095_abnormal_skin_pigmentation0.64037378
139MP0000249_abnormal_blood_vessel0.63916719
140MP0003453_abnormal_keratinocyte_physiol0.63555700
141MP0000350_abnormal_cell_proliferation0.62938111
142MP0008932_abnormal_embryonic_tissue0.61946216
143MP0005166_decreased_susceptibility_to0.60152724
144MP0000372_irregular_coat_pigmentation0.59541596
145MP0000015_abnormal_ear_pigmentation0.58249483
146MP0003943_abnormal_hepatobiliary_system0.58248444

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.39925639
2Eczematoid dermatitis (HP:0000976)5.04829109
3Recurrent bacterial skin infections (HP:0005406)4.81270702
4Acute necrotizing encephalopathy (HP:0006965)4.76665911
5Elevated erythrocyte sedimentation rate (HP:0003565)4.54458523
6Increased hepatocellular lipid droplets (HP:0006565)4.46254294
7Mitochondrial inheritance (HP:0001427)4.29589588
8Acute encephalopathy (HP:0006846)4.29008745
9Abnormal mitochondria in muscle tissue (HP:0008316)4.19277649
10Lipid accumulation in hepatocytes (HP:0006561)4.02028753
11Progressive macrocephaly (HP:0004481)3.96624424
12Increased CSF lactate (HP:0002490)3.94819570
13Myositis (HP:0100614)3.86027140
14Mediastinal lymphadenopathy (HP:0100721)3.83814593
15Abnormality of cells of the erythroid lineage (HP:0012130)3.71663678
16Reticulocytopenia (HP:0001896)3.63182659
17Hepatocellular necrosis (HP:0001404)3.62966869
18Renal Fanconi syndrome (HP:0001994)3.56654741
19Abnormal number of erythroid precursors (HP:0012131)3.54083632
20Recurrent gram-negative bacterial infections (HP:0005420)3.51919660
21Thrombocytosis (HP:0001894)3.43454835
22Increased IgM level (HP:0003496)3.38729251
23Colon cancer (HP:0003003)3.28900414
24Autoimmune thrombocytopenia (HP:0001973)3.28238015
25Cerebral edema (HP:0002181)3.28129354
26Hepatic necrosis (HP:0002605)3.24953242
27Recurrent fungal infections (HP:0002841)3.17217503
28Orchitis (HP:0100796)3.14064558
29Recurrent viral infections (HP:0004429)3.12956753
303-Methylglutaconic aciduria (HP:0003535)3.08700470
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06651932
32Chronic obstructive pulmonary disease (HP:0006510)3.06336793
33Obstructive lung disease (HP:0006536)3.06336793
34Increased intramyocellular lipid droplets (HP:0012240)3.03560755
35Retrobulbar optic neuritis (HP:0100654)2.95551601
36Optic neuritis (HP:0100653)2.95551601
37Oral leukoplakia (HP:0002745)2.95422123
38IgM deficiency (HP:0002850)2.94865651
39Recurrent skin infections (HP:0001581)2.94433301
40Abnormality of macrophages (HP:0004311)2.94161207
41Abnormality of T cell number (HP:0011839)2.91052917
42Chronic otitis media (HP:0000389)2.87838067
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82853607
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82853607
45Petechiae (HP:0000967)2.80797887
46Abnormality of T cells (HP:0002843)2.78441983
47Recurrent bronchitis (HP:0002837)2.74488567
48Pallor (HP:0000980)2.74077771
49Vasculitis (HP:0002633)2.73260568
50T lymphocytopenia (HP:0005403)2.72166906
51Stomatitis (HP:0010280)2.66659214
52Meningitis (HP:0001287)2.65914505
53Vacuolated lymphocytes (HP:0001922)2.65736433
54Respiratory difficulties (HP:0002880)2.65719298
55Abnormality of the labia minora (HP:0012880)2.64672278
56Increased serum lactate (HP:0002151)2.63708922
57IgG deficiency (HP:0004315)2.62001845
58Abnormality of T cell physiology (HP:0011840)2.61662138
59Methylmalonic acidemia (HP:0002912)2.61032850
60Gingivitis (HP:0000230)2.60580255
61Autoimmune hemolytic anemia (HP:0001890)2.58889537
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58732982
63Cellulitis (HP:0100658)2.58705860
64Pancytopenia (HP:0001876)2.57100665
65Lactic acidosis (HP:0003128)2.56120195
66Hypergammaglobulinemia (HP:0010702)2.53366712
67Basal ganglia calcification (HP:0002135)2.51396581
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48071821
69Periodontitis (HP:0000704)2.45423189
70Increased muscle lipid content (HP:0009058)2.43642041
71Poor head control (HP:0002421)2.43509042
72Abnormality of methionine metabolism (HP:0010901)2.43470417
73Recurrent pneumonia (HP:0006532)2.42613961
74Respiratory failure (HP:0002878)2.42149697
75Congenital, generalized hypertrichosis (HP:0004540)2.40713097
76Abnormality of the prostate (HP:0008775)2.37196897
77Pulmonary infiltrates (HP:0002113)2.33963925
78Aplastic anemia (HP:0001915)2.33656305
79Pustule (HP:0200039)2.32488324
80Leukodystrophy (HP:0002415)2.31822585
81Optic disc pallor (HP:0000543)2.31095838
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.27676023
83B lymphocytopenia (HP:0010976)2.27250654
84Abnormality of B cell number (HP:0010975)2.27250654
85Eosinophilia (HP:0001880)2.26895748
86Cellular immunodeficiency (HP:0005374)2.25723939
87Leukocytosis (HP:0001974)2.25554614
88Abnormality of renal resorption (HP:0011038)2.24593789
89Chronic mucocutaneous candidiasis (HP:0002728)2.24241157
90Recurrent cutaneous fungal infections (HP:0011370)2.24241157
91Abnormality of serum amino acid levels (HP:0003112)2.23404730
92Methylmalonic aciduria (HP:0012120)2.22992243
93Vertebral compression fractures (HP:0002953)2.22841641
94Combined immunodeficiency (HP:0005387)2.22176341
95Lethargy (HP:0001254)2.22108764
96Granulocytopenia (HP:0001913)2.20997729
97Lymphopenia (HP:0001888)2.20559337
98Severe combined immunodeficiency (HP:0004430)2.19871957
99Exertional dyspnea (HP:0002875)2.19465284
100Recurrent lower respiratory tract infections (HP:0002783)2.17103962
101Abolished electroretinogram (ERG) (HP:0000550)2.16920165
102Macrocytic anemia (HP:0001972)2.16341900
103Hyperglycinemia (HP:0002154)2.15669319
104IgA deficiency (HP:0002720)2.14895451
105Urticaria (HP:0001025)2.13142769
106Hypoglycemic seizures (HP:0002173)2.11432154
107Exercise intolerance (HP:0003546)2.11363408
108Stenosis of the external auditory canal (HP:0000402)2.10591489
109Reduced antithrombin III activity (HP:0001976)2.09836946
110Interstitial pulmonary disease (HP:0006530)2.09673994
111Keratoconjunctivitis sicca (HP:0001097)2.08704349
112Osteomyelitis (HP:0002754)2.08528081
113Agnosia (HP:0010524)2.08408209
11411 pairs of ribs (HP:0000878)2.07131304
115Skin ulcer (HP:0200042)2.07046637
116Meckel diverticulum (HP:0002245)2.05897687
117Type I transferrin isoform profile (HP:0003642)2.03581629
118Prostate neoplasm (HP:0100787)2.03201411
119Lymphoma (HP:0002665)1.99541732
120Arterial thrombosis (HP:0004420)1.98398967
121Hemoptysis (HP:0002105)1.98198270
122Sparse eyelashes (HP:0000653)1.96789275
123Abnormality of the ileum (HP:0001549)1.96472486
124Absent thumb (HP:0009777)1.95703878
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93948663
126Microvesicular hepatic steatosis (HP:0001414)1.93140325
127Abnormality of eosinophils (HP:0001879)1.92800584
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92509656
129Hyperphosphaturia (HP:0003109)1.92059562
130Abnormality of the preputium (HP:0100587)1.92017196
131Septo-optic dysplasia (HP:0100842)1.90948200
132Hyperglycinuria (HP:0003108)1.89212324
133Abnormal lung lobation (HP:0002101)1.88689793
134Syringomyelia (HP:0003396)1.88505788
135Spinal cord lesions (HP:0100561)1.88505788
136Abnormality of chromosome stability (HP:0003220)1.88443367
137Panhypogammaglobulinemia (HP:0003139)1.87941980
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.87701053
139Abnormal protein glycosylation (HP:0012346)1.87078728
140Abnormal glycosylation (HP:0012345)1.87078728
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87078728
142Abnormal protein N-linked glycosylation (HP:0012347)1.87078728
143Thyroiditis (HP:0100646)1.86836174
144Keratoconjunctivitis (HP:0001096)1.86822876
145Agammaglobulinemia (HP:0004432)1.86035262
146Nasal polyposis (HP:0100582)1.84783928
147Symptomatic seizures (HP:0011145)1.83949076
148Encephalitis (HP:0002383)1.83690612
149Megaloblastic anemia (HP:0001889)1.82886514
150Degeneration of anterior horn cells (HP:0002398)1.82624154
151Abnormality of the anterior horn cell (HP:0006802)1.82624154
152Glycosuria (HP:0003076)1.82092508
153Abnormality of urine glucose concentration (HP:0011016)1.82092508
154Amaurosis fugax (HP:0100576)1.80805865
155Pulmonary fibrosis (HP:0002206)1.78868077
156Cleft eyelid (HP:0000625)1.78081872
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.77146448
158Sepsis (HP:0100806)1.73881697
159Gastrointestinal infarctions (HP:0005244)1.73274199
160Abnormality of glycine metabolism (HP:0010895)1.72932285
161Abnormality of serine family amino acid metabolism (HP:0010894)1.72932285
162Multiple enchondromatosis (HP:0005701)1.72539413
163Generalized aminoaciduria (HP:0002909)1.72510647
164Broad face (HP:0000283)1.70791800
165Pendular nystagmus (HP:0012043)1.70562261
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.70429319
167Osteolytic defects of the hand bones (HP:0009699)1.70429319
168Hypothermia (HP:0002045)1.68141120
169Birth length less than 3rd percentile (HP:0003561)1.67230555
170Pancreatic islet-cell hyperplasia (HP:0004510)1.66397918
171Neoplasm of the adrenal gland (HP:0100631)1.62877274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.49781049
2NME23.50896308
3MAP3K143.26739555
4TXK2.87813289
5MAP4K12.66841593
6IRAK42.65160063
7PIM22.59773174
8TBK12.37229096
9BLK2.34898665
10EIF2AK12.18647364
11TESK12.17878922
12JAK32.15627993
13MKNK22.02323876
14PBK2.00488371
15TRIM281.98272519
16TYK21.95572940
17TNIK1.93036644
18PLK31.90559081
19TAF11.88341016
20IKBKE1.88049955
21ZAP701.82684375
22RIPK41.80789734
23TEC1.77832159
24EIF2AK31.76173110
25RPS6KA41.73915195
26IKBKB1.69973090
27TESK21.61143944
28MST41.59888975
29KIT1.57951596
30IRAK31.57088157
31TTK1.55518798
32WNK31.54801764
33TSSK61.54019483
34BTK1.52167114
35ACVR1B1.45159043
36KDR1.32947102
37CDK191.32905214
38SYK1.32623845
39NEK11.32246165
40MAP3K121.30630865
41DYRK21.28489920
42BUB11.27852493
43NME11.24285281
44EIF2AK21.22657209
45ERN11.19552378
46PIM11.19547434
47MAP4K21.17142455
48BCKDK1.15496494
49ERBB31.14443234
50STK101.13680982
51VRK11.12778007
52MYLK1.10584076
53LRRK21.10411820
54ITK1.08545032
55CHUK1.08521756
56GRK11.07666644
57TGFBR11.07626307
58NEK91.06009902
59LYN1.04481273
60PLK11.03416610
61OXSR11.03398208
62ZAK1.01598367
63LCK0.99344295
64TIE10.99037439
65LIMK10.97780927
66CDC70.97473610
67STK40.94878662
68TRPM70.93764136
69WEE10.92633983
70STK160.92299889
71BRSK20.91101886
72PIK3CG0.90448575
73ADRBK20.90380983
74FLT30.88666004
75JAK10.88554194
76PASK0.85764506
77ALK0.85417338
78SRPK10.83309187
79ILK0.83255640
80BMPR1B0.83157869
81DAPK10.81667230
82EPHA30.80047802
83BMPR20.79920802
84CSK0.79868286
85CSF1R0.78200811
86PLK40.78078279
87YES10.76501260
88TLK10.74678511
89HCK0.74471926
90SIK30.73500305
91AURKB0.72929200
92ABL20.72771169
93CLK10.72583039
94MKNK10.72582729
95STK38L0.72141022
96NUAK10.71372810
97MAP3K110.68718872
98MAP3K100.68169631
99MAP3K30.67743758
100BCR0.67558366
101CSNK1G10.67558270
102MAP2K30.65537562
103NLK0.64459141
104CSNK1G30.62222154
105FES0.62103562
106CSNK2A10.61290215
107ATR0.60981000
108STK240.60382514
109CSNK2A20.59542099
110FRK0.58577485
111MATK0.58308020
112PAK40.57742258
113CCNB10.56985023
114GRK60.55342261
115RPS6KB20.54662002
116PRKCQ0.54214223
117MST1R0.53175503
118CHEK20.51458524
119MAPKAPK20.51143852
120PRKCD0.50598894
121TGFBR20.49869475
122RPS6KA60.49564622
123CSNK1G20.48908938
124INSRR0.46275976
125MARK30.45565656
126SCYL20.44373911
127GRK70.43820274
128TAOK30.43500994
129DYRK30.43442713
130MAP3K50.42948116
131NEK20.42646658
132RPS6KC10.41407959
133RPS6KL10.41407959
134CDK40.41092412
135FGFR30.40758637
136RPS6KA50.40264356
137TAOK20.40213779
138ATM0.39133241
139PDK20.37501017
140STK30.37207575
141AURKA0.31023197
142CSNK1A1L0.30390869
143DAPK30.30109851
144IGF1R0.30109129
145CHEK10.28362203

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.26473750
2Graft-versus-host disease_Homo sapiens_hsa053322.90082320
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.64737661
4Proteasome_Homo sapiens_hsa030502.62595334
5DNA replication_Homo sapiens_hsa030302.54940138
6Leishmaniasis_Homo sapiens_hsa051402.42731560
7Allograft rejection_Homo sapiens_hsa053302.33907962
8Legionellosis_Homo sapiens_hsa051342.13702830
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.09791833
10Protein export_Homo sapiens_hsa030601.94315250
11Primary immunodeficiency_Homo sapiens_hsa053401.91357544
12Measles_Homo sapiens_hsa051621.89967968
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.84789003
14Antigen processing and presentation_Homo sapiens_hsa046121.82659587
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79893505
16Mismatch repair_Homo sapiens_hsa034301.77400719
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71206997
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70395447
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64629055
20Herpes simplex infection_Homo sapiens_hsa051681.64480534
21Type I diabetes mellitus_Homo sapiens_hsa049401.59174339
22Homologous recombination_Homo sapiens_hsa034401.58006264
23Pertussis_Homo sapiens_hsa051331.54381840
24Base excision repair_Homo sapiens_hsa034101.54375374
25Asthma_Homo sapiens_hsa053101.54309455
26Hematopoietic cell lineage_Homo sapiens_hsa046401.50661440
27Malaria_Homo sapiens_hsa051441.47251523
28Spliceosome_Homo sapiens_hsa030401.46976266
29Osteoclast differentiation_Homo sapiens_hsa043801.45913459
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43311253
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43017654
32Shigellosis_Homo sapiens_hsa051311.33956904
33Influenza A_Homo sapiens_hsa051641.32897315
34Pyrimidine metabolism_Homo sapiens_hsa002401.32059922
35RNA polymerase_Homo sapiens_hsa030201.30718899
36Tuberculosis_Homo sapiens_hsa051521.26168112
37Autoimmune thyroid disease_Homo sapiens_hsa053201.26084104
38TNF signaling pathway_Homo sapiens_hsa046681.25050915
39Rheumatoid arthritis_Homo sapiens_hsa053231.24658602
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.24606019
41Nucleotide excision repair_Homo sapiens_hsa034201.24590004
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23365401
43Viral myocarditis_Homo sapiens_hsa054161.23297269
44Salmonella infection_Homo sapiens_hsa051321.23199714
45p53 signaling pathway_Homo sapiens_hsa041151.20665667
46Apoptosis_Homo sapiens_hsa042101.18799105
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16983945
48Toxoplasmosis_Homo sapiens_hsa051451.12150816
49Propanoate metabolism_Homo sapiens_hsa006401.11676596
50Cardiac muscle contraction_Homo sapiens_hsa042601.11431654
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09250941
52Epstein-Barr virus infection_Homo sapiens_hsa051691.05515770
53Fatty acid elongation_Homo sapiens_hsa000621.03598994
54Hepatitis B_Homo sapiens_hsa051611.03532347
55Caffeine metabolism_Homo sapiens_hsa002321.02556084
56Glutathione metabolism_Homo sapiens_hsa004801.02149979
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02015982
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.99881009
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98835947
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97159588
61Phagosome_Homo sapiens_hsa041450.97044791
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96610741
63T cell receptor signaling pathway_Homo sapiens_hsa046600.96394915
64Cell cycle_Homo sapiens_hsa041100.94994767
65B cell receptor signaling pathway_Homo sapiens_hsa046620.92380385
66Staphylococcus aureus infection_Homo sapiens_hsa051500.88523074
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86670721
68RNA degradation_Homo sapiens_hsa030180.85882565
69Non-homologous end-joining_Homo sapiens_hsa034500.85699989
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.85691181
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84171337
72African trypanosomiasis_Homo sapiens_hsa051430.78784211
73RNA transport_Homo sapiens_hsa030130.78749149
74Pyruvate metabolism_Homo sapiens_hsa006200.78713572
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76141746
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76099725
77Selenocompound metabolism_Homo sapiens_hsa004500.75140109
78Parkinsons disease_Homo sapiens_hsa050120.73340620
79Chemokine signaling pathway_Homo sapiens_hsa040620.73298113
80Oxidative phosphorylation_Homo sapiens_hsa001900.73269617
81Peroxisome_Homo sapiens_hsa041460.73102325
82Viral carcinogenesis_Homo sapiens_hsa052030.71911328
83HTLV-I infection_Homo sapiens_hsa051660.71841419
84Fanconi anemia pathway_Homo sapiens_hsa034600.71711697
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71607613
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70048521
87Systemic lupus erythematosus_Homo sapiens_hsa053220.69087224
88Other glycan degradation_Homo sapiens_hsa005110.67664650
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66854654
90Small cell lung cancer_Homo sapiens_hsa052220.66526505
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66003223
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65345597
93Phototransduction_Homo sapiens_hsa047440.65298286
94One carbon pool by folate_Homo sapiens_hsa006700.65073716
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64871484
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63403294
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.62800810
98Metabolic pathways_Homo sapiens_hsa011000.62736472
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61129585
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60365129
101Tryptophan metabolism_Homo sapiens_hsa003800.59361785
102Chemical carcinogenesis_Homo sapiens_hsa052040.58528777
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58488199
104Hepatitis C_Homo sapiens_hsa051600.57093006
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56462599
106Sulfur metabolism_Homo sapiens_hsa009200.56243369
107mRNA surveillance pathway_Homo sapiens_hsa030150.54900152
108Vitamin digestion and absorption_Homo sapiens_hsa049770.53678418
109Retinol metabolism_Homo sapiens_hsa008300.53580068
110Butanoate metabolism_Homo sapiens_hsa006500.53399829
111Collecting duct acid secretion_Homo sapiens_hsa049660.53250216
112Linoleic acid metabolism_Homo sapiens_hsa005910.52702266
113Steroid biosynthesis_Homo sapiens_hsa001000.52672486
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51569607
115Lysosome_Homo sapiens_hsa041420.51423567
116Basal transcription factors_Homo sapiens_hsa030220.51045310
117Acute myeloid leukemia_Homo sapiens_hsa052210.50935414
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50717174
119Huntingtons disease_Homo sapiens_hsa050160.49761292
120N-Glycan biosynthesis_Homo sapiens_hsa005100.47419035
121Platelet activation_Homo sapiens_hsa046110.47124549
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.45685793
123Chronic myeloid leukemia_Homo sapiens_hsa052200.45326892
124Alzheimers disease_Homo sapiens_hsa050100.44841133
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43680933
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.42919538
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41798973
128Amoebiasis_Homo sapiens_hsa051460.41408840
129Purine metabolism_Homo sapiens_hsa002300.41206536
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40917114
131Folate biosynthesis_Homo sapiens_hsa007900.39547831
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38305838
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37816967
134Pancreatic cancer_Homo sapiens_hsa052120.37611633
135Regulation of autophagy_Homo sapiens_hsa041400.36603094
136Arachidonic acid metabolism_Homo sapiens_hsa005900.36124946
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34469650
138Carbon metabolism_Homo sapiens_hsa012000.33329446
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32076828
140HIF-1 signaling pathway_Homo sapiens_hsa040660.31944828
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31623966
142Fatty acid degradation_Homo sapiens_hsa000710.30886742
143Thyroid cancer_Homo sapiens_hsa052160.30255523
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.27756747
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26713000
146Fat digestion and absorption_Homo sapiens_hsa049750.25128066
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25043458
148Vitamin B6 metabolism_Homo sapiens_hsa007500.22450663
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21427367

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