ABI3BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.21751275
2collagen fibril organization (GO:0030199)6.82087618
3bone trabecula formation (GO:0060346)5.99036110
4sequestering of extracellular ligand from receptor (GO:0035581)5.75748919
5extracellular fibril organization (GO:0043206)5.50875659
6extracellular matrix assembly (GO:0085029)5.20052080
7fibril organization (GO:0097435)5.01988689
8lymphangiogenesis (GO:0001946)4.98023424
9atrioventricular valve morphogenesis (GO:0003181)4.83755094
10keratan sulfate catabolic process (GO:0042340)4.80192368
11cell migration involved in heart development (GO:0060973)4.65578663
12endocardial cushion development (GO:0003197)4.63557332
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.54547544
14skin morphogenesis (GO:0043589)4.53032193
15collagen metabolic process (GO:0032963)4.35314780
16collagen catabolic process (GO:0030574)4.27004168
17peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.21542408
18dermatan sulfate biosynthetic process (GO:0030208)4.12836698
19multicellular organismal macromolecule metabolic process (GO:0044259)4.12622194
20basement membrane organization (GO:0071711)3.98866042
21endodermal cell differentiation (GO:0035987)3.98377816
22negative regulation of cardiac muscle tissue growth (GO:0055022)3.96209187
23negative regulation of heart growth (GO:0061117)3.96209187
24multicellular organismal catabolic process (GO:0044243)3.95453422
25multicellular organismal metabolic process (GO:0044236)3.93924561
26chondrocyte proliferation (GO:0035988)3.89769890
27virion attachment to host cell (GO:0019062)3.84401551
28adhesion of symbiont to host cell (GO:0044650)3.84401551
29dermatan sulfate metabolic process (GO:0030205)3.75526944
30peptidyl-proline hydroxylation (GO:0019511)3.72519889
31regulation of cardioblast differentiation (GO:0051890)3.71133178
32extracellular matrix disassembly (GO:0022617)3.68648290
33vascular endothelial growth factor signaling pathway (GO:0038084)3.68479678
34atrial septum morphogenesis (GO:0060413)3.65856385
35regulation of integrin-mediated signaling pathway (GO:2001044)3.62827026
36cellular response to vitamin (GO:0071295)3.57541185
37endothelium development (GO:0003158)3.56433308
38endothelial cell morphogenesis (GO:0001886)3.55345476
39negative regulation of chondrocyte differentiation (GO:0032331)3.51253505
40substrate-dependent cell migration (GO:0006929)3.46073921
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.43825119
42axon extension involved in axon guidance (GO:0048846)3.43825119
43blood vessel maturation (GO:0001955)3.41111881
44venous blood vessel morphogenesis (GO:0048845)3.38366049
45extracellular negative regulation of signal transduction (GO:1900116)3.32026931
46extracellular regulation of signal transduction (GO:1900115)3.32026931
47negative regulation of nitric-oxide synthase activity (GO:0051001)3.31795169
48positive regulation of blood vessel endothelial cell migration (GO:0043536)3.31526779
49* extracellular matrix organization (GO:0030198)3.23996121
50apoptotic cell clearance (GO:0043277)3.23336757
51* extracellular structure organization (GO:0043062)3.22718127
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22266339
53cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19374264
54prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.18471033
55epithelial cell-cell adhesion (GO:0090136)3.17846504
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17838760
57adhesion of symbiont to host (GO:0044406)3.16980487
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15408785
59protein hydroxylation (GO:0018126)3.14050785
60cell adhesion mediated by integrin (GO:0033627)3.14044730
61opsonization (GO:0008228)3.13766734
62substrate adhesion-dependent cell spreading (GO:0034446)3.12434152
63positive regulation of endothelial cell apoptotic process (GO:2000353)3.10679218
64cellular response to interferon-alpha (GO:0035457)3.08215674
65cell proliferation involved in metanephros development (GO:0072203)3.06770906
66metanephric mesenchyme development (GO:0072075)3.05033907
67chondrocyte development (GO:0002063)3.01125498
68regulation of plasminogen activation (GO:0010755)3.01072138
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.00427646
70regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.99632969
71regulation of tight junction assembly (GO:2000810)2.99240419
72glomerular basement membrane development (GO:0032836)2.97560439
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96479204
74type B pancreatic cell proliferation (GO:0044342)2.94850519
75cell migration involved in sprouting angiogenesis (GO:0002042)2.94679749
76regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.94011376
77sprouting angiogenesis (GO:0002040)2.93523603
78craniofacial suture morphogenesis (GO:0097094)2.92015497
79negative regulation of complement activation (GO:0045916)2.91845962
80myoblast migration (GO:0051451)2.91003836
81negative regulation of epithelial to mesenchymal transition (GO:0010719)2.89892024
82pericardium development (GO:0060039)2.89212354
83glomerular filtration (GO:0003094)2.87659930
84regulation of secondary heart field cardioblast proliferation (GO:0003266)2.87590671
85regulation of cardioblast proliferation (GO:0003264)2.87590671
86blood vessel remodeling (GO:0001974)2.86469749
87positive regulation of fibroblast migration (GO:0010763)2.85744620
88regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.84745037
89negative regulation of cartilage development (GO:0061037)2.84282457
90negative regulation of BMP signaling pathway (GO:0030514)2.83688543
91peptide cross-linking (GO:0018149)2.79542962
92negative regulation of smooth muscle cell migration (GO:0014912)2.78449088
93negative regulation of catenin import into nucleus (GO:0035414)2.78151544
94trabecula formation (GO:0060343)2.77608078
95epoxygenase P450 pathway (GO:0019373)2.77204220
96mesenchymal-epithelial cell signaling (GO:0060638)2.77093750
97regulation of extracellular matrix disassembly (GO:0010715)2.74837904
98renal filtration (GO:0097205)2.74692862
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74517774
100heart valve morphogenesis (GO:0003179)2.73848413
101wound healing, spreading of epidermal cells (GO:0035313)2.73746377
102negative regulation of fatty acid transport (GO:2000192)2.72175131
103endocrine hormone secretion (GO:0060986)2.72008515
104face morphogenesis (GO:0060325)2.70594353
105negative regulation of embryonic development (GO:0045992)2.69856603
106kidney mesenchyme development (GO:0072074)2.69695313
107peripheral nervous system axon ensheathment (GO:0032292)2.69029910
108myelination in peripheral nervous system (GO:0022011)2.69029910
109regulation of epithelial to mesenchymal transition (GO:0010717)2.68875898
110fibroblast migration (GO:0010761)2.68159659
111protein targeting to plasma membrane (GO:0072661)2.67783595
112regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.66390276
113positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65964008
114cellular response to vitamin D (GO:0071305)2.65548419
115protein carboxylation (GO:0018214)2.65457843
116peptidyl-glutamic acid carboxylation (GO:0017187)2.65457843
117negative regulation of fibroblast apoptotic process (GO:2000270)2.64558815
118muscle cell migration (GO:0014812)2.64151304
119positive regulation of natural killer cell differentiation (GO:0032825)2.63695660
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63485109
121positive regulation of endothelial cell migration (GO:0010595)2.63206005
122smooth muscle tissue development (GO:0048745)2.62570877
123branching involved in prostate gland morphogenesis (GO:0060442)2.61164355
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61067092
125negative regulation of protein localization to cell surface (GO:2000009)2.60629849
126endothelial cell proliferation (GO:0001935)2.58309465
127ventricular septum development (GO:0003281)2.57543924
128positive regulation of receptor recycling (GO:0001921)2.56785227
129positive regulation of stem cell differentiation (GO:2000738)2.56775034
130embryonic cranial skeleton morphogenesis (GO:0048701)2.56059823
131regulation of metalloenzyme activity (GO:0048552)2.55427745
132platelet-derived growth factor receptor signaling pathway (GO:0048008)2.53882004
133cell-substrate junction assembly (GO:0007044)2.53791476
134positive regulation of osteoblast proliferation (GO:0033690)2.50646432
135negative regulation of endothelial cell proliferation (GO:0001937)2.50268203
136wound healing (GO:0042060)2.47538276
137cell proliferation involved in kidney development (GO:0072111)2.44985581
138negative regulation of platelet activation (GO:0010544)2.42917167
139cardiac myofibril assembly (GO:0055003)2.42772453
140lymph vessel development (GO:0001945)2.42416745
141positive regulation of epithelial cell migration (GO:0010634)2.41206716
142regulation of fibroblast migration (GO:0010762)2.40892908
143regulation of chondrocyte differentiation (GO:0032330)2.40698148
144cell-substrate adhesion (GO:0031589)2.40346075
145tissue remodeling (GO:0048771)2.39697391
146barbed-end actin filament capping (GO:0051016)2.39539426
147regulation of chemokine-mediated signaling pathway (GO:0070099)2.39210600
148regulation of transforming growth factor beta2 production (GO:0032909)2.38381556
149wound healing, spreading of cells (GO:0044319)2.37692327
150hyaluronan catabolic process (GO:0030214)2.37542482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.39255787
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.69801540
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.68275911
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.59438321
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.82320217
6CLOCK_20551151_ChIP-Seq_293T_Human2.61242138
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47021773
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.45328318
9* CJUN_26792858_Chip-Seq_BT549_Human2.41193158
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.40752987
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.15328532
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14455923
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.14396290
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09589254
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.09169577
16NRF2_20460467_ChIP-Seq_MEFs_Mouse2.03484823
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.03484823
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.02025039
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97386061
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.95802222
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95784106
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88084159
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84358261
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84239502
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81792892
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81792892
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76602553
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70615875
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.69558093
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68995891
31TP53_16413492_ChIP-PET_HCT116_Human1.67317249
32TP53_18474530_ChIP-ChIP_U2OS_Human1.65618084
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62078623
34* BRD4_25478319_ChIP-Seq_HGPS_Human1.58291763
35AR_21572438_ChIP-Seq_LNCaP_Human1.57463303
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56047242
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48973402
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46529830
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41642842
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41091866
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40864663
42GBX2_23144817_ChIP-Seq_PC3_Human1.40754000
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40486305
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39185383
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38549197
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37431257
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33182163
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31864755
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31462538
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.30964413
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27951600
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.26953844
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.26589871
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25736522
55DROSHA_22980978_ChIP-Seq_HELA_Human1.20285789
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20226940
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.17831042
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.17619542
59SOX2_20726797_ChIP-Seq_SW620_Human1.17379217
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.17071750
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16968500
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16166964
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.15966197
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.15966197
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.15540491
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14864206
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14075692
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11542966
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.11337969
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11216726
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11174882
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10629360
73BCAT_22108803_ChIP-Seq_LS180_Human1.07824385
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06930884
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06014613
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05520803
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04121812
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03718212
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.03395582
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02933880
81* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02830666
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01741794
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01640708
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01640708
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01334242
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01203775
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.00971558
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98753257
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.98205939
90FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98067096
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97364087
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96194699
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96111406
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95825758
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94435421
96AHR_22903824_ChIP-Seq_MCF-7_Human0.94216611
97* TP63_23658742_ChIP-Seq_EP156T_Human0.92871511
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.92465105
99* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92330146
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.91231574
101RXR_22108803_ChIP-Seq_LS180_Human0.90570080
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89914697
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89476188
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89314302
105SA1_22415368_ChIP-Seq_MEFs_Mouse0.88548680
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88044875
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.88003938
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87821226
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87780194
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.87604740
111* STAT3_23295773_ChIP-Seq_U87_Human0.87385768
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.87321956
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86567322
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86476805
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.86473648
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86418504
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86184042
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85623883
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84728166
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84354230
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84226216
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.83887989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.06186322
2MP0005503_abnormal_tendon_morphology7.85840804
3MP0005275_abnormal_skin_tensile6.67267212
4MP0003705_abnormal_hypodermis_morpholog4.41594418
5MP0003279_aneurysm4.03617541
6MP0001958_emphysema3.97096779
7MP0009384_cardiac_valve_regurgitation3.36690693
8MP0006054_spinal_hemorrhage2.59464160
9MP0005257_abnormal_intraocular_pressure2.54152873
10MP0002108_abnormal_muscle_morphology2.52879907
11MP0005508_abnormal_skeleton_morphology2.45875650
12MP0004272_abnormal_basement_membrane2.27890338
13MP0002060_abnormal_skin_morphology2.11558468
14MP0002295_abnormal_pulmonary_circulatio2.01575836
15MP0001542_abnormal_bone_strength1.70124460
16MP0000751_myopathy1.65979462
17MP0010368_abnormal_lymphatic_system1.65065682
18MP0009250_abnormal_appendicular_skeleto1.59286405
19MP0005023_abnormal_wound_healing1.55657507
20MP0003566_abnormal_cell_adhesion1.46384080
21MP0004084_abnormal_cardiac_muscle1.45564090
22MP0005390_skeleton_phenotype1.43523686
23MP0002933_joint_inflammation1.41719043
24MP0003385_abnormal_body_wall1.37192650
25MP0005623_abnormal_meninges_morphology1.36693412
26MP0000767_abnormal_smooth_muscle1.33182539
27MP0001243_abnormal_dermal_layer1.31466504
28MP0000013_abnormal_adipose_tissue1.22893498
29MP0002896_abnormal_bone_mineralization1.16614267
30MP0004134_abnormal_chest_morphology1.11839399
31MP0003724_increased_susceptibility_to1.10322208
32MP0005171_absent_coat_pigmentation1.09483112
33MP0002115_abnormal_skeleton_extremities1.02301885
34MP0000163_abnormal_cartilage_morphology1.01972618
35MP0002133_abnormal_respiratory_system1.01340882
36MP0005388_respiratory_system_phenotype1.01340882
37MP0003115_abnormal_respiratory_system1.01044204
38MP0002282_abnormal_trachea_morphology0.97368555
39MP0003091_abnormal_cell_migration0.97101983
40MP0003011_delayed_dark_adaptation0.93343233
41MP0004036_abnormal_muscle_relaxation0.92498193
42MP0005595_abnormal_vascular_smooth0.92234607
43MP0002168_other_aberrant_phenotype0.91709610
44MP0001533_abnormal_skeleton_physiology0.90608644
45MP0003045_fibrosis0.90152692
46MP0001177_atelectasis0.90114825
47MP0002837_dystrophic_cardiac_calcinosis0.89489473
48MP0001299_abnormal_eye_distance/0.87998635
49MP0005369_muscle_phenotype0.86347387
50MP0002998_abnormal_bone_remodeling0.83357578
51MP0003828_pulmonary_edema0.80818466
52MP0002249_abnormal_larynx_morphology0.80688855
53MP0002932_abnormal_joint_morphology0.79907645
54MP0000003_abnormal_adipose_tissue0.79781759
55MP0004883_abnormal_blood_vessel0.78244482
56MP0001879_abnormal_lymphatic_vessel0.76913210
57MP0010030_abnormal_orbit_morphology0.74498429
58MP0000569_abnormal_digit_pigmentation0.74415429
59MP0002113_abnormal_skeleton_development0.74143160
60MP0010352_gastrointestinal_tract_polyps0.73398088
61MP0000733_abnormal_muscle_development0.72445897
62MP0003252_abnormal_bile_duct0.72303663
63MP0000428_abnormal_craniofacial_morphol0.72060507
64MP0003191_abnormal_cellular_cholesterol0.72031051
65MP0002128_abnormal_blood_circulation0.71913797
66MP0005164_abnormal_response_to0.71748118
67MP0005670_abnormal_white_adipose0.70944408
68MP0001661_extended_life_span0.70719065
69MP0005367_renal/urinary_system_phenotyp0.69889912
70MP0000516_abnormal_urinary_system0.69889912
71MP0003300_gastrointestinal_ulcer0.69772089
72MP0008775_abnormal_heart_ventricle0.69720128
73MP0000749_muscle_degeneration0.68146973
74MP0000249_abnormal_blood_vessel0.67956376
75MP0010386_abnormal_urinary_bladder0.67498020
76MP0000534_abnormal_ureter_morphology0.65945576
77MP0002796_impaired_skin_barrier0.65534565
78MP0004233_abnormal_muscle_weight0.65336442
79MP0000759_abnormal_skeletal_muscle0.64737457
80MP0002925_abnormal_cardiovascular_devel0.64089627
81MP0009780_abnormal_chondrocyte_physiolo0.64019417
82MP0002109_abnormal_limb_morphology0.63738564
83MP0000750_abnormal_muscle_regeneration0.63270070
84MP0001175_abnormal_lung_morphology0.62995472
85MP0004484_altered_response_of0.62991137
86MP0003950_abnormal_plasma_membrane0.62879997
87MP0003941_abnormal_skin_development0.62741823
88MP0000343_altered_response_to0.62616333
89MP0004782_abnormal_surfactant_physiolog0.60959215
90MP0002089_abnormal_postnatal_growth/wei0.60255308
91MP0000230_abnormal_systemic_arterial0.60244426
92MP0003795_abnormal_bone_structure0.60023825
93MP0004215_abnormal_myocardial_fiber0.59871986
94MP0002972_abnormal_cardiac_muscle0.59684586
95MP0002332_abnormal_exercise_endurance0.59325852
96MP0004858_abnormal_nervous_system0.58857905
97MP0003942_abnormal_urinary_system0.58073225
98MP0002106_abnormal_muscle_physiology0.56873541
99MP0010771_integument_phenotype0.56539229
100MP0004087_abnormal_muscle_fiber0.56394955
101MP0001614_abnormal_blood_vessel0.56283204
102MP0009053_abnormal_anal_canal0.55258225
103MP0005620_abnormal_muscle_contractility0.53897467
104MP0001915_intracranial_hemorrhage0.53874796
105MP0003283_abnormal_digestive_organ0.53390326
106MP0005197_abnormal_uvea_morphology0.53188159
107MP0000432_abnormal_head_morphology0.51905931
108MP0003755_abnormal_palate_morphology0.51506433
109MP0000747_muscle_weakness0.51367567
110MP0005385_cardiovascular_system_phenoty0.51297879
111MP0001544_abnormal_cardiovascular_syste0.51297879
112MP0000049_abnormal_middle_ear0.50854113
113MP0008004_abnormal_stomach_pH0.50464836
114MP0003448_altered_tumor_morphology0.50447000
115MP0005375_adipose_tissue_phenotype0.50105650
116MP0005165_increased_susceptibility_to0.49719380
117MP0005330_cardiomyopathy0.49554040
118MP0002254_reproductive_system_inflammat0.49545921
119MP0004145_abnormal_muscle_electrophysio0.49205343
120MP0006138_congestive_heart_failure0.49086925
121MP0000762_abnormal_tongue_morphology0.49072629

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.91365466
2Premature rupture of membranes (HP:0001788)8.01324937
3Aortic dissection (HP:0002647)5.79176979
4Aortic aneurysm (HP:0004942)5.65847318
5Broad metatarsal (HP:0001783)5.58937978
6Ankle contracture (HP:0006466)5.49534373
7Soft skin (HP:0000977)5.47723300
8Bladder diverticulum (HP:0000015)4.89832450
9Peritonitis (HP:0002586)4.79584641
10Shallow orbits (HP:0000586)4.56984674
11Atrophic scars (HP:0001075)4.54695321
12Dilatation of the ascending aorta (HP:0005111)4.44788505
13Follicular hyperkeratosis (HP:0007502)4.28213565
14Vascular tortuosity (HP:0004948)4.24656648
15Vertebral compression fractures (HP:0002953)4.12138489
16Type 1 muscle fiber predominance (HP:0003803)4.05900640
17Wrist flexion contracture (HP:0001239)4.03794712
18Fragile skin (HP:0001030)4.01965068
19Arterial tortuosity (HP:0005116)3.85762775
20Cerebral aneurysm (HP:0004944)3.80027552
21Wormian bones (HP:0002645)3.74195938
22Genu recurvatum (HP:0002816)3.66954026
23Overgrowth (HP:0001548)3.62488874
24Mitral valve prolapse (HP:0001634)3.59647472
25Biconcave vertebral bodies (HP:0004586)3.58464431
26Abnormality of dentin (HP:0010299)3.51845484
27Blue sclerae (HP:0000592)3.48169641
28Cervical subluxation (HP:0003308)3.42810843
29Spinal rigidity (HP:0003306)3.28252413
30Slender build (HP:0001533)3.27706029
31Bowel diverticulosis (HP:0005222)3.26770038
32Spondylolisthesis (HP:0003302)3.25762978
33Hyperextensible skin (HP:0000974)3.24580572
34Neonatal short-limb short stature (HP:0008921)3.20654395
35Increased connective tissue (HP:0009025)3.20574992
36Abnormal delivery (HP:0001787)3.00844978
37Round ear (HP:0100830)2.93053484
38Aneurysm (HP:0002617)2.90829813
39Ectopia lentis (HP:0001083)2.76502207
40Increased variability in muscle fiber diameter (HP:0003557)2.67814778
41Infantile muscular hypotonia (HP:0008947)2.59035227
42Striae distensae (HP:0001065)2.58602899
43Abnormality of the acetabulum (HP:0003170)2.57026767
44Ulnar deviation of the wrist (HP:0003049)2.55041582
45Mitral stenosis (HP:0001718)2.53380878
46Distal arthrogryposis (HP:0005684)2.53285033
47Bell-shaped thorax (HP:0001591)2.52875804
48Joint laxity (HP:0001388)2.52371012
49Mildly elevated creatine phosphokinase (HP:0008180)2.50760911
50Osteolytic defects of the hand bones (HP:0009699)2.48783514
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.48783514
52Broad ribs (HP:0000885)2.48596400
53Thin bony cortex (HP:0002753)2.45002115
54Breech presentation (HP:0001623)2.44840784
55Elbow flexion contracture (HP:0002987)2.39047105
56Wide anterior fontanel (HP:0000260)2.38828762
57Osteoarthritis (HP:0002758)2.34323235
58Abnormality of skeletal muscle fiber size (HP:0012084)2.33833943
59Right ventricular cardiomyopathy (HP:0011663)2.32865286
60Joint stiffness (HP:0001387)2.29907206
61Camptodactyly of toe (HP:0001836)2.29272518
62Cardiovascular calcification (HP:0011915)2.26644354
63Pulmonary artery stenosis (HP:0004415)2.24775069
64Coronal craniosynostosis (HP:0004440)2.20049178
65Coxa vara (HP:0002812)2.19794078
66Mitral regurgitation (HP:0001653)2.17568172
67Venous insufficiency (HP:0005293)2.16791987
68Aortic regurgitation (HP:0001659)2.13054111
69Flat cornea (HP:0007720)2.11837565
70Venous abnormality (HP:0002624)2.10644598
71Increased corneal curvature (HP:0100692)2.09357540
72Keratoconus (HP:0000563)2.09357540
73Hematochezia (HP:0002573)2.01775581
74Flared iliac wings (HP:0002869)2.00110400
75Muscle fiber splitting (HP:0003555)1.97619581
76Inguinal hernia (HP:0000023)1.97333040
77Beaking of vertebral bodies (HP:0004568)1.96247356
78Abnormality of the peritoneum (HP:0002585)1.94550564
79Deviation of the hallux (HP:0010051)1.94209141
80Mesomelia (HP:0003027)1.93442850
81Nonimmune hydrops fetalis (HP:0001790)1.92665510
82Disproportionate tall stature (HP:0001519)1.90191844
83Delayed closure of the anterior fontanelle (HP:0001476)1.88516065
84Hallux valgus (HP:0001822)1.84110394
85Deformed tarsal bones (HP:0008119)1.82896199
86Decreased skull ossification (HP:0004331)1.82777887
87Aortic valve stenosis (HP:0001650)1.81826597
88Spontaneous hematomas (HP:0007420)1.80273447
89Thin skin (HP:0000963)1.79425061
90Osteopenia (HP:0000938)1.78999769
91Tarsal synostosis (HP:0008368)1.78008079
92Alopecia of scalp (HP:0002293)1.77494327
93Generalized amyotrophy (HP:0003700)1.77294952
94Limited hip movement (HP:0008800)1.77126912
95Mild short stature (HP:0003502)1.76830135
96Abnormality of the anterior chamber (HP:0000593)1.76725713
97Hypoplasia of the iris (HP:0007676)1.76658208
98Abnormality of skull ossification (HP:0002703)1.75469943
99Popliteal pterygium (HP:0009756)1.74558849
100Nemaline bodies (HP:0003798)1.72436045
101Delayed cranial suture closure (HP:0000270)1.72108663
102Hip contracture (HP:0003273)1.71838694
103Emphysema (HP:0002097)1.70362644
104Ovoid vertebral bodies (HP:0003300)1.69578174
105Protruding ear (HP:0000411)1.69164718
106Metaphyseal dysplasia (HP:0100255)1.68740757
107Joint contractures involving the joints of the feet (HP:0100492)1.68438863
108Flexion contracture of toe (HP:0005830)1.68438863
109Morphological abnormality of the middle ear (HP:0008609)1.68281834
110Reduced subcutaneous adipose tissue (HP:0003758)1.68206294
111Narrow nasal bridge (HP:0000446)1.67920199
112Hypoplasia of the odontoid process (HP:0003311)1.67247820
113Tibial bowing (HP:0002982)1.67083475
114Calcaneovalgus deformity (HP:0001848)1.65470148
115Redundant skin (HP:0001582)1.64745066
116Hypoventilation (HP:0002791)1.62965562
117Femoral bowing (HP:0002980)1.61640264
118Knee flexion contracture (HP:0006380)1.61303503
119Hyporeflexia of lower limbs (HP:0002600)1.60576977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.28180583
2LATS23.90246340
3LATS13.62177525
4ERN13.51340300
5EPHA33.27532127
6PDGFRA3.26666591
7TTN3.04545409
8SIK12.59305045
9TRIB32.45863816
10DMPK2.36278980
11EPHB22.31529299
12TGFBR22.24767878
13MYLK2.06700386
14PIK3CA2.06151863
15FER2.05832224
16RIPK11.99303534
17TGFBR11.95002959
18OBSCN1.66829173
19NUAK11.49146340
20PTK2B1.45179654
21MUSK1.43888131
22PAK21.42145769
23PAK31.41035180
24MET1.34818896
25NEK91.30463035
26PIM21.27353328
27PIK3CG1.26806965
28FRK1.26480351
29AKT31.26077978
30STK31.25717759
31EPHB11.25220541
32TESK11.24399994
33JAK11.21267501
34PTK21.19204691
35PKN21.18577437
36MST1R1.17474686
37PDGFRB1.14533256
38WNK11.09443079
39MAP3K31.08065914
40FGFR41.07687102
41NTRK11.07455956
42FGFR11.04298899
43MAP3K60.99892146
44ROCK10.95759510
45BMX0.94924814
46PAK40.93497517
47MELK0.92300110
48FGFR20.90011511
49ADRBK10.89175365
50FGFR30.86905133
51MAP2K10.85825497
52LMTK20.85051240
53CAMK1D0.84595717
54NLK0.84189546
55PLK20.83337594
56TRPM70.81332405
57PDK20.80536390
58STK38L0.80486657
59PRKCH0.77527321
60PRKD10.77449092
61FLT30.75470026
62GRK10.75215125
63MAP3K20.74834799
64RET0.71744566
65MAP4K20.71608689
66WNK40.68281318
67PRKD20.67675727
68TAOK10.67381664
69MOS0.67271926
70RPS6KA40.67240809
71MAP3K70.67051427
72CAMK1G0.65977263
73ILK0.65861933
74RPS6KA20.65610321
75STK240.64865317
76EEF2K0.64738775
77MTOR0.63289794
78PRKG20.62706024
79MAPKAPK50.62125417
80PTK60.61010847
81GRK50.60056171
82ZAK0.58398208
83LRRK20.57516315
84ROCK20.57074019
85TEC0.57071385
86CDK60.56235186
87PDK40.54667933
88PDK30.54667933
89JAK30.52478967
90KIT0.52314492
91MAP3K130.52140899
92CAMKK20.52086522
93MAP3K50.49269796
94ABL20.48688494
95KDR0.47071078
96CDC42BPA0.44305740
97ABL10.44158049
98DAPK30.44130410
99MAPKAPK30.44057270
100GSK3A0.43374115
101INSR0.43331451
102ERBB40.42411739
103RAF10.41431732
104LIMK10.41168985
105PAK60.40754182
106MAPK70.39109340
107MAPK40.38667107
108PRKCE0.38096511
109TIE10.37723642
110MAPK110.37612077
111PRKG10.37571307
112SRC0.37379515
113PRKAA20.37359224
114KSR20.36041097
115ERBB30.35591083
116CAMKK10.34684960
117MARK20.34553706
118STK380.34174181
119SGK30.33846759
120MAPK10.33227843
121SGK20.32703358
122PRKD30.31621885
123PHKG20.30772589
124PHKG10.30772589
125MAP2K30.29681526
126MAPK120.29355706
127PDPK10.27461941
128CLK10.25029321
129ARAF0.23095649
130MARK10.23039101

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.44949711
2Protein digestion and absorption_Homo sapiens_hsa049742.86597715
3Focal adhesion_Homo sapiens_hsa045102.81711537
4Malaria_Homo sapiens_hsa051442.70623420
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.53822451
6Dilated cardiomyopathy_Homo sapiens_hsa054142.45478366
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.44306886
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14226543
9Amoebiasis_Homo sapiens_hsa051462.10644683
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.10309622
11TGF-beta signaling pathway_Homo sapiens_hsa043501.93977240
12Proteoglycans in cancer_Homo sapiens_hsa052051.88598361
13Adherens junction_Homo sapiens_hsa045201.69726425
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53817558
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.45903077
16Complement and coagulation cascades_Homo sapiens_hsa046101.35595350
17Caffeine metabolism_Homo sapiens_hsa002321.31064550
18Mineral absorption_Homo sapiens_hsa049781.29828942
19Bladder cancer_Homo sapiens_hsa052191.29053784
20Hippo signaling pathway_Homo sapiens_hsa043901.17977501
21Dorso-ventral axis formation_Homo sapiens_hsa043201.15800980
22Melanoma_Homo sapiens_hsa052181.15726041
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12068140
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.09591519
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07232304
26MicroRNAs in cancer_Homo sapiens_hsa052061.04981583
27Viral myocarditis_Homo sapiens_hsa054161.02834830
28Pertussis_Homo sapiens_hsa051331.02240746
29Platelet activation_Homo sapiens_hsa046111.00430635
30Insulin resistance_Homo sapiens_hsa049311.00414135
31Basal cell carcinoma_Homo sapiens_hsa052170.99085030
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96247494
33Small cell lung cancer_Homo sapiens_hsa052220.95933043
34Wnt signaling pathway_Homo sapiens_hsa043100.95519428
35Leukocyte transendothelial migration_Homo sapiens_hsa046700.93014154
36TNF signaling pathway_Homo sapiens_hsa046680.91422885
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.87888398
38Glioma_Homo sapiens_hsa052140.85526312
39Pathways in cancer_Homo sapiens_hsa052000.84110050
40Chronic myeloid leukemia_Homo sapiens_hsa052200.82930772
41Toxoplasmosis_Homo sapiens_hsa051450.81785617
42Rap1 signaling pathway_Homo sapiens_hsa040150.81316685
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78833168
44Starch and sucrose metabolism_Homo sapiens_hsa005000.78659919
45GnRH signaling pathway_Homo sapiens_hsa049120.78444477
46Axon guidance_Homo sapiens_hsa043600.78340389
47PPAR signaling pathway_Homo sapiens_hsa033200.77365719
48Prostate cancer_Homo sapiens_hsa052150.77352139
49Pancreatic cancer_Homo sapiens_hsa052120.76558750
50Melanogenesis_Homo sapiens_hsa049160.75708524
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74388288
52Chemical carcinogenesis_Homo sapiens_hsa052040.73840324
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71454412
54Calcium signaling pathway_Homo sapiens_hsa040200.70403144
55Salivary secretion_Homo sapiens_hsa049700.69545054
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69066763
57Thyroid hormone synthesis_Homo sapiens_hsa049180.68682341
58Ovarian steroidogenesis_Homo sapiens_hsa049130.68153252
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.67720229
60Phagosome_Homo sapiens_hsa041450.67390237
61Estrogen signaling pathway_Homo sapiens_hsa049150.67333956
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67093390
63Hedgehog signaling pathway_Homo sapiens_hsa043400.66369930
64Oxytocin signaling pathway_Homo sapiens_hsa049210.65268958
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63660814
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63623955
67Arachidonic acid metabolism_Homo sapiens_hsa005900.63549738
68HIF-1 signaling pathway_Homo sapiens_hsa040660.62680021
69Prion diseases_Homo sapiens_hsa050200.62404674
70Gastric acid secretion_Homo sapiens_hsa049710.61908932
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61643669
72Sphingolipid metabolism_Homo sapiens_hsa006000.61537261
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.61488542
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60961175
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60334202
76Tight junction_Homo sapiens_hsa045300.59425003
77Gap junction_Homo sapiens_hsa045400.58731139
78Renal cell carcinoma_Homo sapiens_hsa052110.57845126
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57478803
80Ras signaling pathway_Homo sapiens_hsa040140.56336270
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55735090
82Rheumatoid arthritis_Homo sapiens_hsa053230.55537006
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54671797
84Endocytosis_Homo sapiens_hsa041440.53466225
85Nitrogen metabolism_Homo sapiens_hsa009100.53265523
86FoxO signaling pathway_Homo sapiens_hsa040680.52127655
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51960392
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51136167
89Insulin signaling pathway_Homo sapiens_hsa049100.50864623
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49828350
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49808375
92Glucagon signaling pathway_Homo sapiens_hsa049220.49380013
93cAMP signaling pathway_Homo sapiens_hsa040240.49230128
94Pancreatic secretion_Homo sapiens_hsa049720.49006411
95Renin secretion_Homo sapiens_hsa049240.48640126
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47952844
97AMPK signaling pathway_Homo sapiens_hsa041520.47479434
98Choline metabolism in cancer_Homo sapiens_hsa052310.47313236
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.46006211
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45769509
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.44879016
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.44084381
103Phototransduction_Homo sapiens_hsa047440.43988875
104MAPK signaling pathway_Homo sapiens_hsa040100.43879376
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43408334
106Lysosome_Homo sapiens_hsa041420.43247554
107Shigellosis_Homo sapiens_hsa051310.43102159
108ABC transporters_Homo sapiens_hsa020100.42971589
109Fatty acid degradation_Homo sapiens_hsa000710.42582220
110Serotonergic synapse_Homo sapiens_hsa047260.42543797
111Lysine degradation_Homo sapiens_hsa003100.42498606
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42112934
113Renin-angiotensin system_Homo sapiens_hsa046140.41359849
114Osteoclast differentiation_Homo sapiens_hsa043800.40668143
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40432076
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40360626
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.40248597
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39586773
119Circadian rhythm_Homo sapiens_hsa047100.39396941
120mTOR signaling pathway_Homo sapiens_hsa041500.38700151
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38511955
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.38331568
123Histidine metabolism_Homo sapiens_hsa003400.37617227

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