ABHD13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.87463182
2Golgi transport vesicle coating (GO:0048200)5.87463182
3positive regulation of gamma-delta T cell activation (GO:0046645)5.34438678
4cellular response to ethanol (GO:0071361)4.69667695
5regulation of B cell receptor signaling pathway (GO:0050855)4.67467852
6protein localization to endosome (GO:0036010)4.66392676
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44946614
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42654768
9cytoplasmic mRNA processing body assembly (GO:0033962)4.36533453
10neutrophil activation involved in immune response (GO:0002283)4.16626670
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.09248474
12histone H2A monoubiquitination (GO:0035518)4.09135064
13COPII vesicle coating (GO:0048208)4.07989706
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.06051651
15negative regulation of thymocyte apoptotic process (GO:0070244)4.02179885
16cellular response to interleukin-15 (GO:0071350)3.98868335
17positive regulation of nuclease activity (GO:0032075)3.92584582
18negative regulation of T cell mediated immunity (GO:0002710)3.90965185
19glucocorticoid receptor signaling pathway (GO:0042921)3.86870595
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.85166193
21modulation by symbiont of host immune response (GO:0052553)3.85166193
22positive regulation by symbiont of host defense response (GO:0052509)3.85166193
23modulation by symbiont of host defense response (GO:0052031)3.85166193
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85166193
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85166193
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83969419
27neutrophil mediated immunity (GO:0002446)3.80080831
28response to interleukin-15 (GO:0070672)3.79714632
29negative regulation of interleukin-12 production (GO:0032695)3.77542895
30regulation of gamma-delta T cell activation (GO:0046643)3.72954266
31cellular extravasation (GO:0045123)3.72571283
32response to peptidoglycan (GO:0032494)3.67320671
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64988304
34detection of molecule of bacterial origin (GO:0032490)3.61321309
35UDP-N-acetylglucosamine metabolic process (GO:0006047)3.61242518
36folic acid-containing compound biosynthetic process (GO:0009396)3.57024284
37regulation of nuclease activity (GO:0032069)3.54517444
38interferon-gamma production (GO:0032609)3.52745403
39neutrophil activation (GO:0042119)3.50697583
40vesicle coating (GO:0006901)3.50283125
41granulocyte activation (GO:0036230)3.46384059
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.44176339
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.42812861
44positive regulation of histone deacetylation (GO:0031065)3.41392105
45endoplasmic reticulum unfolded protein response (GO:0030968)3.38869014
46B cell proliferation (GO:0042100)3.38141398
47detection of other organism (GO:0098543)3.37821074
48regulation of gamma-delta T cell differentiation (GO:0045586)3.34997145
49negative T cell selection (GO:0043383)3.34903751
50ER-nucleus signaling pathway (GO:0006984)3.34542108
51antigen processing and presentation of endogenous antigen (GO:0019883)3.33321202
52regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.32889516
53protein retention in ER lumen (GO:0006621)3.32103069
54macrophage activation involved in immune response (GO:0002281)3.31237641
55growth hormone receptor signaling pathway (GO:0060396)3.30916696
56corticosteroid receptor signaling pathway (GO:0031958)3.30438033
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29665548
58response to hydroperoxide (GO:0033194)3.29084260
59regulation of interferon-beta biosynthetic process (GO:0045357)3.28493311
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28046240
61intestinal epithelial cell development (GO:0060576)3.25800028
62myeloid leukocyte mediated immunity (GO:0002444)3.25101110
63establishment of protein localization to Golgi (GO:0072600)3.23817810
64V(D)J recombination (GO:0033151)3.23817743
65negative thymic T cell selection (GO:0045060)3.22805628
66B cell receptor signaling pathway (GO:0050853)3.21322423
67cellular response to unfolded protein (GO:0034620)3.20145095
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19145025
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18515572
70monoubiquitinated protein deubiquitination (GO:0035520)3.17402342
71cell adhesion mediated by integrin (GO:0033627)3.16794364
72regulation of alpha-beta T cell proliferation (GO:0046640)3.15679354
73insulin-like growth factor receptor signaling pathway (GO:0048009)3.15530650
74T cell migration (GO:0072678)3.15256474
75regulation of regulatory T cell differentiation (GO:0045589)3.15197607
76response to host immune response (GO:0052572)3.14723885
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14723885
78positive regulation of granulocyte differentiation (GO:0030854)3.14306801
79regulation of interleukin-8 biosynthetic process (GO:0045414)3.14050034
80regulation of T-helper 1 cell differentiation (GO:0045625)3.13221342
81myeloid cell activation involved in immune response (GO:0002275)3.11435127
82histone H2A ubiquitination (GO:0033522)3.10118224
83nuclear pore complex assembly (GO:0051292)3.08496031
84negative regulation of B cell proliferation (GO:0030889)3.07868268
85regulation of Golgi to plasma membrane protein transport (GO:0042996)3.06942641
86detection of external biotic stimulus (GO:0098581)3.06751891
87intestinal absorption (GO:0050892)3.04837126
88negative regulation of T cell apoptotic process (GO:0070233)3.03119949
89T cell homeostasis (GO:0043029)3.02793592
90mitotic sister chromatid cohesion (GO:0007064)3.02787708
91positive regulation of nitric-oxide synthase activity (GO:0051000)3.00007502
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98773673
93regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97151002
94interleukin-6-mediated signaling pathway (GO:0070102)2.96868382
95positive T cell selection (GO:0043368)2.96538283
96tolerance induction (GO:0002507)2.95995844
97leukocyte degranulation (GO:0043299)2.95542360
98immunoglobulin mediated immune response (GO:0016064)2.94639799
99response to muramyl dipeptide (GO:0032495)2.94599937
100cellular response to topologically incorrect protein (GO:0035967)2.94494985
101positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.93511401
102L-alpha-amino acid transmembrane transport (GO:1902475)2.92713065
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92306407
104negative regulation of T-helper cell differentiation (GO:0045623)2.92306407
105microglial cell activation (GO:0001774)2.92215670
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90650876
107positive regulation of protein localization to plasma membrane (GO:1903078)2.90488003
108leukocyte aggregation (GO:0070486)2.90053364
109detection of bacterium (GO:0016045)2.89699298
110production of molecular mediator involved in inflammatory response (GO:0002532)2.89555139
111regulation of B cell differentiation (GO:0045577)2.89388239
112respiratory burst (GO:0045730)2.88701953
113peptidyl-lysine dimethylation (GO:0018027)2.86986332
114regulation of RNA export from nucleus (GO:0046831)2.86280262
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85617336
116sulfur amino acid catabolic process (GO:0000098)2.84295089
117endoplasmic reticulum organization (GO:0007029)2.83913006
118regulation of clathrin-mediated endocytosis (GO:2000369)2.82656302
119regulation of T cell tolerance induction (GO:0002664)2.82393911
120negative regulation of interleukin-17 production (GO:0032700)2.82262645
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.81693242
122regulation of interferon-alpha production (GO:0032647)2.80009424
123positive regulation of interferon-alpha production (GO:0032727)2.78161060
124macrophage activation (GO:0042116)2.77320369
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76806013
1264-hydroxyproline metabolic process (GO:0019471)2.75944225
127positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.75090290
128embryonic foregut morphogenesis (GO:0048617)2.74549226
129regulation of interleukin-12 biosynthetic process (GO:0045075)2.74494657
130dendritic cell migration (GO:0036336)2.73914898
131cysteine metabolic process (GO:0006534)2.73896442
132regulation of tolerance induction (GO:0002643)2.73428605
133negative regulation of leukocyte mediated immunity (GO:0002704)2.73259887
134hepatocyte apoptotic process (GO:0097284)2.72693985
135regulation of fibroblast apoptotic process (GO:2000269)2.72483196
136negative regulation of type 2 immune response (GO:0002829)2.71087013
137response to endoplasmic reticulum stress (GO:0034976)2.70515386
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69985140
139lymphocyte proliferation (GO:0046651)2.69938215
140negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.69724613
141positive regulation of interferon-beta production (GO:0032728)2.69540969
142regulation of interleukin-17 production (GO:0032660)2.68207141
143B cell mediated immunity (GO:0019724)2.67260061
144negative regulation of NF-kappaB import into nucleus (GO:0042347)2.66866125
145cellular response to growth hormone stimulus (GO:0071378)2.66621793
146dorsal/ventral axis specification (GO:0009950)2.66123089
147gene silencing by RNA (GO:0031047)2.65542370
148regulation of transforming growth factor beta2 production (GO:0032909)2.64889975
149L-serine transport (GO:0015825)2.64134042
150type B pancreatic cell development (GO:0003323)2.63504036
151protein targeting to Golgi (GO:0000042)2.61554660
152hippo signaling (GO:0035329)2.59703689
153negative regulation of hormone biosynthetic process (GO:0032353)2.59100191
154negative regulation of hormone metabolic process (GO:0032351)2.59100191
155histone H3-K9 demethylation (GO:0033169)2.59092916
156lysine metabolic process (GO:0006553)2.58529393
157lysine catabolic process (GO:0006554)2.58529393
158one-carbon metabolic process (GO:0006730)2.57460399
159regulation of nucleobase-containing compound transport (GO:0032239)2.56937916
160regulation of cholesterol homeostasis (GO:2000188)2.54359310
161positive regulation of glycoprotein metabolic process (GO:1903020)2.53623577
162nuclear pore organization (GO:0006999)2.51650818
163ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.51647048
164protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.51516719
165positive regulation of glycolytic process (GO:0045821)2.51342156
166serine transport (GO:0032329)2.51102076
167regulation of sister chromatid cohesion (GO:0007063)2.50678143
168urea metabolic process (GO:0019627)2.50002612
169urea cycle (GO:0000050)2.50002612
170regulation of transforming growth factor beta1 production (GO:0032908)2.49638626
171regulation of ARF protein signal transduction (GO:0032012)2.47684279
172response to unfolded protein (GO:0006986)2.45602937
173negative regulation of histone methylation (GO:0031061)2.43920262
174Golgi organization (GO:0007030)2.43655091
175negative regulation of cell killing (GO:0031342)2.41564432
176negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41564432
177fatty acid homeostasis (GO:0055089)2.41308510
178peptidyl-asparagine modification (GO:0018196)2.40343794
179retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39826496
180hemidesmosome assembly (GO:0031581)2.38990728
181protein N-linked glycosylation via asparagine (GO:0018279)2.38346229
182regulation of translational termination (GO:0006449)2.38193764
183ER overload response (GO:0006983)2.37780601
184valine metabolic process (GO:0006573)2.37710299
185negative regulation of lipid transport (GO:0032369)2.34923941
186regulation of Rac protein signal transduction (GO:0035020)2.34006293
187pre-miRNA processing (GO:0031054)2.32870413
188regulation of hormone biosynthetic process (GO:0046885)2.32241099
189SMAD protein complex assembly (GO:0007183)2.32128863
190response to topologically incorrect protein (GO:0035966)2.32101451
191intestinal cholesterol absorption (GO:0030299)2.31182750
192early endosome to late endosome transport (GO:0045022)2.29865586
193zinc ion transport (GO:0006829)2.29745391
194zinc ion transmembrane transport (GO:0071577)2.29115348
195regulation of protein localization to plasma membrane (GO:1903076)2.29114238
196positive regulation of p38MAPK cascade (GO:1900745)2.28487161
197regulation of alkaline phosphatase activity (GO:0010692)2.28015002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.93932631
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.90687549
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.47810135
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.17660781
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05855969
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.65444472
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.30625212
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.17755939
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.12280873
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.02007735
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78269359
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.77757939
13CLOCK_20551151_ChIP-Seq_293T_Human2.77024998
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71033918
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69497742
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.62199238
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55458334
18RUNX_20019798_ChIP-Seq_JUKART_Human2.54692279
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51161967
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.47996294
21GATA1_22025678_ChIP-Seq_K562_Human2.45827794
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43272119
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42126306
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.36385161
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.36212880
26AR_21909140_ChIP-Seq_LNCAP_Human2.35042372
27MYB_26560356_Chip-Seq_TH2_Human2.30002736
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.19294666
29LXR_22158963_ChIP-Seq_LIVER_Mouse2.19215126
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.13945335
31MYC_22102868_ChIP-Seq_BL_Human2.12135243
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09947840
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.06003549
34PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05597341
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04093983
36SPI1_23547873_ChIP-Seq_NB4_Human2.01697616
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01184221
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.98429066
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92529801
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.87231915
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86561205
42CHD1_26751641_Chip-Seq_LNCaP_Human1.84366113
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77299056
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76684672
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76390565
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75637347
47MYB_26560356_Chip-Seq_TH1_Human1.75104621
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75101290
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71041831
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68603132
51ATF3_27146783_Chip-Seq_COLON_Human1.67757024
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66209716
53GATA6_25053715_ChIP-Seq_YYC3_Human1.65087200
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.63155336
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62342495
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.60626977
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53876375
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51511844
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50754212
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49126677
61GATA3_26560356_Chip-Seq_TH2_Human1.49099937
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48623895
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46794788
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.46017653
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45764042
66ZNF263_19887448_ChIP-Seq_K562_Human1.45730164
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45592152
68* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.45057270
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44791221
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44525088
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43456838
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.42953519
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41755295
74VDR_24787735_ChIP-Seq_THP-1_Human1.41614377
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.40023619
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39753728
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38525002
78VDR_23849224_ChIP-Seq_CD4+_Human1.37653507
79TFEB_21752829_ChIP-Seq_HELA_Human1.37530942
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37376168
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36916997
82PU_27001747_Chip-Seq_BMDM_Mouse1.36303824
83TCF7_22412390_ChIP-Seq_EML_Mouse1.34157143
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33920622
85IGF1R_20145208_ChIP-Seq_DFB_Human1.32570355
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.32482347
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31356426
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.31034539
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30768081
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29875798
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29572614
92* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28632645
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28381016
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28020762
95BRD4_25478319_ChIP-Seq_HGPS_Human1.27837139
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27763887
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.27153696
98TP53_16413492_ChIP-PET_HCT116_Human1.26637278
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.25178148
100TAF15_26573619_Chip-Seq_HEK293_Human1.24761791
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24069569
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24069569
103ELK1_19687146_ChIP-ChIP_HELA_Human1.22117494
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.22109400
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21898631
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21830514
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.19970853
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19345207
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.18096829
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17193791
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16577272
112TP63_23658742_ChIP-Seq_EP156T_Human1.15779873
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15615218
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14575770
115KDM2B_26808549_Chip-Seq_DND41_Human1.13884633
116* GATA4_25053715_ChIP-Seq_YYC3_Human1.13807228
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13616795
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12898292
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08983520
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08887049
121GATA3_24758297_ChIP-Seq_MCF-7_Human1.08741299
122FOXA1_25552417_ChIP-Seq_VCAP_Human1.08060465
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07854809
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06798152
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.05567055
126CREB1_26743006_Chip-Seq_LNCaP_Human1.05319622
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04862160
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04617134
129SOX2_20726797_ChIP-Seq_SW620_Human1.04526009
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03397390
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02706741
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02678516
133SPI1_23127762_ChIP-Seq_K562_Human1.02505549
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02487475
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02224009
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.01365135
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01236801
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00995778
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.00756927
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00282593
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.99353050
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99166031
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98912166
144RACK7_27058665_Chip-Seq_MCF-7_Human0.98344484
145* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98315820
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97859867
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.97646076
148SCL_19346495_ChIP-Seq_HPC-7_Human0.97557798
149RXR_22108803_ChIP-Seq_LS180_Human0.96901485
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96428002
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.96157700
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95870694
153ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95753329
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94877601
155TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94877472
156E2F7_22180533_ChIP-Seq_HELA_Human0.94520344
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.94455595
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94437409
159SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94265954
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93948586
161MAF_26560356_Chip-Seq_TH1_Human0.92389568
162NMYC_18555785_Chip-Seq_ESCs_Mouse0.92315802
163KDM2B_26808549_Chip-Seq_K562_Human0.91842333
164CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91791596
165EWS_26573619_Chip-Seq_HEK293_Human0.91695673
166E2F1_18555785_Chip-Seq_ESCs_Mouse0.91560087
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.91535944
168MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91383539
169E2F1_21310950_ChIP-Seq_MCF-7_Human0.91376228
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.90175072
171CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89964857
172BCAT_22108803_ChIP-Seq_LS180_Human0.89708072
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88661691
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88661691
175PRDM14_20953172_ChIP-Seq_ESCs_Human0.88178540
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87879330
177GATA3_27048872_Chip-Seq_THYMUS_Human0.87873389
178ER_23166858_ChIP-Seq_MCF-7_Human0.87065350
179CDX2_22108803_ChIP-Seq_LS180_Human0.86959650
180CJUN_26792858_Chip-Seq_BT549_Human0.86635103
181NANOG_21062744_ChIP-ChIP_HESCs_Human0.85974012
182IRF1_19129219_ChIP-ChIP_H3396_Human0.85865761
183OCT4_18555785_Chip-Seq_ESCs_Mouse0.85626895
184* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85080274
185P300_18555785_Chip-Seq_ESCs_Mouse0.84296042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.06561524
2MP0002877_abnormal_melanocyte_morpholog3.96149795
3MP0001835_abnormal_antigen_presentation3.95953407
4MP0003705_abnormal_hypodermis_morpholog3.72670259
5MP0003300_gastrointestinal_ulcer3.47147594
6MP0005671_abnormal_response_to3.34100166
7MP0003724_increased_susceptibility_to3.32401504
8MP0009785_altered_susceptibility_to3.19706787
9MP0010352_gastrointestinal_tract_polyps2.79122721
10MP0002139_abnormal_hepatobiliary_system2.78255693
11MP0000685_abnormal_immune_system2.76287590
12MP0001800_abnormal_humoral_immune2.72376545
13MP0003436_decreased_susceptibility_to2.71614096
14MP0005000_abnormal_immune_tolerance2.64350746
15MP0004185_abnormal_adipocyte_glucose2.62648389
16MP0010678_abnormal_skin_adnexa2.54326049
17MP0005387_immune_system_phenotype2.53842831
18MP0001790_abnormal_immune_system2.53842831
19MP0002148_abnormal_hypersensitivity_rea2.48992723
20MP0002723_abnormal_immune_serum2.31315729
21MP0002132_abnormal_respiratory_system2.30186170
22MP0003763_abnormal_thymus_physiology2.29621713
23MP0002419_abnormal_innate_immunity2.27727473
24MP0004264_abnormal_extraembryonic_tissu2.25464028
25MP0006082_CNS_inflammation2.23972594
26MP0002452_abnormal_antigen_presenting2.22488996
27MP0005360_urolithiasis2.21530342
28MP0009780_abnormal_chondrocyte_physiolo2.21133575
29MP0001666_abnormal_nutrient_absorption2.14462897
30MP0002420_abnormal_adaptive_immunity2.13202526
31MP0005451_abnormal_body_composition2.12889067
32MP0005187_abnormal_penis_morphology2.12389028
33MP0005025_abnormal_response_to2.12048485
34MP0001819_abnormal_immune_cell2.11191071
35MP0005076_abnormal_cell_differentiation2.10819108
36MP0003868_abnormal_feces_composition2.04807398
37MP0003252_abnormal_bile_duct2.01480871
38MP0000537_abnormal_urethra_morphology2.00953418
39MP0005365_abnormal_bile_salt1.97047669
40MP0006054_spinal_hemorrhage1.97045897
41MP0010155_abnormal_intestine_physiology1.94637168
42MP0009384_cardiac_valve_regurgitation1.92715103
43MP0005085_abnormal_gallbladder_physiolo1.86990847
44MP0003172_abnormal_lysosome_physiology1.85118924
45MP0000465_gastrointestinal_hemorrhage1.82534458
46MP0002398_abnormal_bone_marrow1.81535411
47MP0000569_abnormal_digit_pigmentation1.76933615
48MP0003656_abnormal_erythrocyte_physiolo1.76291595
49MP0005275_abnormal_skin_tensile1.73067677
50MP0005220_abnormal_exocrine_pancreas1.71019626
51MP0003828_pulmonary_edema1.70927074
52MP0002796_impaired_skin_barrier1.67804459
53MP0000716_abnormal_immune_system1.67630895
54MP0000689_abnormal_spleen_morphology1.67338511
55MP0001545_abnormal_hematopoietic_system1.66272021
56MP0005397_hematopoietic_system_phenotyp1.66272021
57MP0002405_respiratory_system_inflammati1.65501929
58MP0008260_abnormal_autophagy1.63321470
59MP0003453_abnormal_keratinocyte_physiol1.59732097
60MP0005464_abnormal_platelet_physiology1.57936714
61MP0002722_abnormal_immune_system1.57375465
62MP0001845_abnormal_inflammatory_respons1.56854977
63MP0000579_abnormal_nail_morphology1.50224423
64MP0001849_ear_inflammation1.49292542
65MP0009278_abnormal_bone_marrow1.45564212
66MP0000703_abnormal_thymus_morphology1.44917557
67MP0002909_abnormal_adrenal_gland1.43571679
68MP0009764_decreased_sensitivity_to1.43527304
69MP0004510_myositis1.41138014
70MP0000427_abnormal_hair_cycle1.39712605
71MP0008057_abnormal_DNA_replication1.36933979
72MP0003890_abnormal_embryonic-extraembry1.36099446
73MP0001944_abnormal_pancreas_morphology1.35777668
74MP0004947_skin_inflammation1.34081476
75MP0002138_abnormal_hepatobiliary_system1.33176908
76MP0000383_abnormal_hair_follicle1.33034070
77MP0002396_abnormal_hematopoietic_system1.32085624
78MP0003221_abnormal_cardiomyocyte_apopto1.29434804
79MP0002429_abnormal_blood_cell1.27216364
80MP0003787_abnormal_imprinting1.24863793
81MP0000377_abnormal_hair_follicle1.24835316
82MP0001533_abnormal_skeleton_physiology1.24751570
83MP0008438_abnormal_cutaneous_collagen1.24551173
84MP0002896_abnormal_bone_mineralization1.24033978
85MP0008877_abnormal_DNA_methylation1.23547999
86MP0002060_abnormal_skin_morphology1.23152832
87MP0003566_abnormal_cell_adhesion1.20973784
88MP0000013_abnormal_adipose_tissue1.19441539
89MP0005666_abnormal_adipose_tissue1.18775144
90MP0002254_reproductive_system_inflammat1.16848427
91MP0000462_abnormal_digestive_system1.15357522
92MP0010307_abnormal_tumor_latency1.15270583
93MP0008469_abnormal_protein_level1.14252387
94MP0001915_intracranial_hemorrhage1.12377181
95MP0002998_abnormal_bone_remodeling1.10892668
96MP0002693_abnormal_pancreas_physiology1.10659841
97MP0005075_abnormal_melanosome_morpholog1.10534087
98MP0002166_altered_tumor_susceptibility1.10020595
99MP0009053_abnormal_anal_canal1.09371257
100MP0010329_abnormal_lipoprotein_level1.08894723
101MP0005248_abnormal_Harderian_gland1.08138912
102MP0000609_abnormal_liver_physiology1.06566225
103MP0002277_abnormal_respiratory_mucosa1.06533659
104MP0005310_abnormal_salivary_gland1.06281648
105MP0003866_abnormal_defecation1.05886100
106MP0004272_abnormal_basement_membrane1.05524453
107MP0000604_amyloidosis1.04929080
108MP0002332_abnormal_exercise_endurance1.04187145
109MP0005023_abnormal_wound_healing1.03278645
110MP0001853_heart_inflammation1.02711193
111MP0001851_eye_inflammation1.02371086
112MP0002086_abnormal_extraembryonic_tissu1.02138169
113MP0004130_abnormal_muscle_cell1.01757448
114MP0003448_altered_tumor_morphology1.01554784
115MP0001299_abnormal_eye_distance/1.00531249
116MP0002098_abnormal_vibrissa_morphology1.00116830
117MP0003091_abnormal_cell_migration1.00015629
118MP0004197_abnormal_fetal_growth/weight/0.99527650
119MP0001730_embryonic_growth_arrest0.98579183
120MP0002876_abnormal_thyroid_physiology0.97391897
121MP0003329_amyloid_beta_deposits0.97013228
122MP0001216_abnormal_epidermal_layer0.97001412
123MP0004808_abnormal_hematopoietic_stem0.96980034
124MP0003283_abnormal_digestive_organ0.96926356
125MP0004883_abnormal_blood_vessel0.96298491
126MP0009333_abnormal_splenocyte_physiolog0.95753045
127MP0003123_paternal_imprinting0.95570069
128MP0003303_peritoneal_inflammation0.95530159
129MP0005501_abnormal_skin_physiology0.91313787
130MP0002933_joint_inflammation0.88668411
131MP0004957_abnormal_blastocyst_morpholog0.88387549
132MP0005375_adipose_tissue_phenotype0.86406265
133MP0003119_abnormal_digestive_system0.86076892
134MP0002084_abnormal_developmental_patter0.84154515
135MP0004381_abnormal_hair_follicle0.83419400
136MP0005164_abnormal_response_to0.82944932
137MP0000003_abnormal_adipose_tissue0.82671705
138MP0008004_abnormal_stomach_pH0.81589075
139MP0001191_abnormal_skin_condition0.81170521
140MP0003191_abnormal_cellular_cholesterol0.79687098
141MP0000350_abnormal_cell_proliferation0.78869459
142MP0004043_abnormal_pH_regulation0.76581103
143MP0001881_abnormal_mammary_gland0.76493451
144MP0001873_stomach_inflammation0.76275335
145MP0010771_integument_phenotype0.75362663
146MP0008875_abnormal_xenobiotic_pharmacok0.74685518
147MP0005166_decreased_susceptibility_to0.74192329
148MP0005083_abnormal_biliary_tract0.73535439
149MP0000733_abnormal_muscle_development0.73458784
150MP0000428_abnormal_craniofacial_morphol0.72330977
151MP0004859_abnormal_synaptic_plasticity0.71416398
152MP0002089_abnormal_postnatal_growth/wei0.71314600
153MP0001177_atelectasis0.69975059
154MP0004233_abnormal_muscle_weight0.69812353
155MP0009763_increased_sensitivity_to0.69719724
156MP0000477_abnormal_intestine_morphology0.69593187
157MP0000647_abnormal_sebaceous_gland0.69545383
158MP0004484_altered_response_of0.69350239
159MP0002078_abnormal_glucose_homeostasis0.69231982
160MP0003183_abnormal_peptide_metabolism0.69138081
161MP0002088_abnormal_embryonic_growth/wei0.68889418
162MP0010368_abnormal_lymphatic_system0.68782538
163MP0002009_preneoplasia0.68556099
164MP0009672_abnormal_birth_weight0.67875281
165MP0002006_tumorigenesis0.67839224
166MP0000015_abnormal_ear_pigmentation0.67719426
167MP0000490_abnormal_crypts_of0.67589743
168MP0009703_decreased_birth_body0.66926786
169MP0003045_fibrosis0.66765562
170MP0001697_abnormal_embryo_size0.66683473
171MP0005408_hypopigmentation0.66321418
172MP0005167_abnormal_blood-brain_barrier0.66280854
173MP0002019_abnormal_tumor_incidence0.65424783
174MP0005380_embryogenesis_phenotype0.64978840
175MP0001672_abnormal_embryogenesis/_devel0.64978840
176MP0009765_abnormal_xenobiotic_induced0.63169091
177MP0001188_hyperpigmentation0.60928836
178MP0000858_altered_metastatic_potential0.60197478
179MP0005084_abnormal_gallbladder_morpholo0.59989300
180MP0000249_abnormal_blood_vessel0.57197469
181MP0001879_abnormal_lymphatic_vessel0.57154178
182MP0008873_increased_physiological_sensi0.55467791
183MP0002928_abnormal_bile_duct0.54944614

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.26339550
2B lymphocytopenia (HP:0010976)7.14931136
3Abnormality of B cell number (HP:0010975)6.50082957
4Abnormality of T cell number (HP:0011839)6.40151683
5Severe combined immunodeficiency (HP:0004430)6.34468707
6Thyroiditis (HP:0100646)6.26188575
7Hypoplasia of the thymus (HP:0000778)5.96529487
8Panhypogammaglobulinemia (HP:0003139)5.53251633
9Combined immunodeficiency (HP:0005387)5.32584544
10Hypoproteinemia (HP:0003075)5.11808720
11Eosinophilia (HP:0001880)4.68450430
12Stomatitis (HP:0010280)4.44799416
13Recurrent fungal infections (HP:0002841)4.18744525
14Abnormality of eosinophils (HP:0001879)4.17010859
15Subacute progressive viral hepatitis (HP:0006572)4.09074628
16Recurrent viral infections (HP:0004429)4.07011313
17Optic neuritis (HP:0100653)3.93165349
18Retrobulbar optic neuritis (HP:0100654)3.93165349
19Granulocytopenia (HP:0001913)3.89920855
20Leukocytosis (HP:0001974)3.83122668
21Abnormality of T cells (HP:0002843)3.77891900
22IgG deficiency (HP:0004315)3.73586766
23Recurrent bacterial skin infections (HP:0005406)3.73314829
24Myositis (HP:0100614)3.63416060
25Orchitis (HP:0100796)3.62335278
26Recurrent abscess formation (HP:0002722)3.47915785
27Hematochezia (HP:0002573)3.47858938
28Biliary tract neoplasm (HP:0100574)3.37620736
29Meningitis (HP:0001287)3.35214259
30Eczematoid dermatitis (HP:0000976)3.30488649
31Keratoconjunctivitis sicca (HP:0001097)3.23992431
32Deep venous thrombosis (HP:0002625)3.20135671
33Epiphyseal dysplasia (HP:0002656)3.05711064
34Keratoconjunctivitis (HP:0001096)3.02901479
35Ankyloglossia (HP:0010296)2.89222177
36Abnormality of macrophages (HP:0004311)2.85312749
37Autoimmune hemolytic anemia (HP:0001890)2.83229774
38Erythroderma (HP:0001019)2.80807315
39Micronodular cirrhosis (HP:0001413)2.78273113
40Cortical dysplasia (HP:0002539)2.70256070
41Exostoses (HP:0100777)2.67032869
42Recurrent skin infections (HP:0001581)2.64456853
43Neoplasm of the tracheobronchial system (HP:0100552)2.63710516
44Encephalitis (HP:0002383)2.63653741
45Elevated erythrocyte sedimentation rate (HP:0003565)2.63204444
46Chronic mucocutaneous candidiasis (HP:0002728)2.61867520
47Recurrent cutaneous fungal infections (HP:0011370)2.61867520
48Abnormality of oral frenula (HP:0000190)2.60903369
49Gastrointestinal infarctions (HP:0005244)2.56769088
50Mitral valve prolapse (HP:0001634)2.55381622
51Sepsis (HP:0100806)2.54328577
52Recurrent bronchitis (HP:0002837)2.53175900
53Disinhibition (HP:0000734)2.50873969
54Spastic diplegia (HP:0001264)2.48405111
55Episodic fever (HP:0001954)2.47381071
56Pulmonary infiltrates (HP:0002113)2.46239559
57Alveolar cell carcinoma (HP:0006519)2.42504243
58Mediastinal lymphadenopathy (HP:0100721)2.42123566
59Hyperglycemia (HP:0003074)2.37504052
60Abnormal foot bone ossification (HP:0010675)2.36626824
61Papillary thyroid carcinoma (HP:0002895)2.36346548
62Hypoglycemic coma (HP:0001325)2.35622400
63Cervical subluxation (HP:0003308)2.35567790
64Recurrent gram-negative bacterial infections (HP:0005420)2.35564600
65Abnormal biliary tract morphology (HP:0012440)2.32861273
66Hypoglycemic seizures (HP:0002173)2.31374994
67Chronic diarrhea (HP:0002028)2.30942812
68Vasculitis (HP:0002633)2.30796294
69Rectal prolapse (HP:0002035)2.30544441
70Agammaglobulinemia (HP:0004432)2.28846177
71Genu recurvatum (HP:0002816)2.26598500
72Arterial tortuosity (HP:0005116)2.25584740
73Macroorchidism (HP:0000053)2.24930145
74Abnormality of the common coagulation pathway (HP:0010990)2.23699445
75Hemoptysis (HP:0002105)2.23103968
76Spontaneous hematomas (HP:0007420)2.20708981
77Abnormality of endocrine pancreas physiology (HP:0012093)2.18736630
78Abnormality of the pancreatic islet cells (HP:0006476)2.18736630
79Acute hepatic failure (HP:0006554)2.16539212
80Aplasia/Hypoplasia of the thymus (HP:0010515)2.15483646
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.15325766
82Hepatocellular carcinoma (HP:0001402)2.13623347
83Viral hepatitis (HP:0006562)2.13585790
84Amyotrophic lateral sclerosis (HP:0007354)2.12173797
85Abnormal tarsal ossification (HP:0008369)2.12091457
86Pustule (HP:0200039)2.10910225
87Arterial thrombosis (HP:0004420)2.10667515
88Aneurysm (HP:0002617)2.10547749
89Cerebral aneurysm (HP:0004944)2.10065968
90Neoplasm of the small intestine (HP:0100833)2.09831692
91Gingivitis (HP:0000230)2.09726079
92Abnormality of the intrinsic pathway (HP:0010989)2.08717692
93Intrahepatic cholestasis (HP:0001406)2.08340009
94Neoplasm of the rectum (HP:0100743)2.06498865
95Hyperinsulinemic hypoglycemia (HP:0000825)2.06249916
96Abnormality of the Achilles tendon (HP:0005109)2.04753190
97Aortic aneurysm (HP:0004942)2.02668433
98Ketoacidosis (HP:0001993)2.01802076
99Achilles tendon contracture (HP:0001771)2.00775273
100Abnormal cartilage morphology (HP:0002763)1.98060091
101Ulnar bowing (HP:0003031)1.93515019
102Abnormality of glycolipid metabolism (HP:0010969)1.92940789
103Abnormality of liposaccharide metabolism (HP:0010968)1.92940789
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.92940789
105Megalencephaly (HP:0001355)1.92711178
106Enlarged epiphyses (HP:0010580)1.92130923
107Spondylolisthesis (HP:0003302)1.91819172
108Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91718426
109Hemangiomatosis (HP:0007461)1.91472538
110Hypobetalipoproteinemia (HP:0003563)1.91364683
111Gingival bleeding (HP:0000225)1.91268159
112Anorexia (HP:0002039)1.91074908
113Vascular tortuosity (HP:0004948)1.90415243
114Visceral angiomatosis (HP:0100761)1.90256663
115Lymphoma (HP:0002665)1.90186159
116Xanthomatosis (HP:0000991)1.89835365
117Fatigue (HP:0012378)1.89078423
118Gangrene (HP:0100758)1.88961894
119Osteomyelitis (HP:0002754)1.88184533
120Chest pain (HP:0100749)1.87741454
121Abnormality of the thymus (HP:0000777)1.87022873
122Thyroid carcinoma (HP:0002890)1.86437020
123Increased IgM level (HP:0003496)1.86413005
124Urticaria (HP:0001025)1.86236703
125Protrusio acetabuli (HP:0003179)1.85915319
126Insulin-resistant diabetes mellitus (HP:0000831)1.84711956
127Villous atrophy (HP:0011473)1.84630525
128Abnormality of small intestinal villus morphology (HP:0011472)1.84630525
129Uterine neoplasm (HP:0010784)1.84228790
130IgM deficiency (HP:0002850)1.83617615
131Cellulitis (HP:0100658)1.82312712
132Pulmonary embolism (HP:0002204)1.81979453
133Hamartoma of the eye (HP:0010568)1.81789444
134Fibrous tissue neoplasm (HP:0012316)1.81498391
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81151895
136Short 1st metacarpal (HP:0010034)1.81151895
137Termporal pattern (HP:0011008)1.80926737
138Insidious onset (HP:0003587)1.80926737
139Papilledema (HP:0001085)1.80839099
140Conjunctival hamartoma (HP:0100780)1.80253584
141Gastrointestinal carcinoma (HP:0002672)1.80036796
142Malignant gastrointestinal tract tumors (HP:0006749)1.80036796
143Flat acetabular roof (HP:0003180)1.79749277
144Sandal gap (HP:0001852)1.79670195
145Bladder neoplasm (HP:0009725)1.79503779
146Bladder carcinoma (HP:0002862)1.79503779
147Cubitus valgus (HP:0002967)1.78588872
148Fibroma (HP:0010614)1.77893165
149Hypoplastic ischia (HP:0003175)1.76806896
150Curly hair (HP:0002212)1.76659727
151Polygenic inheritance (HP:0010982)1.76336315
152Angiofibromas (HP:0010615)1.75649565
153Adenoma sebaceum (HP:0009720)1.75649565
154Protuberant abdomen (HP:0001538)1.75368400
155Overgrowth (HP:0001548)1.75267308
156Increased density of long bones (HP:0006392)1.75252845
157Keratitis (HP:0000491)1.74957986
158Lymphangioma (HP:0100764)1.74748635
159Osteolytic defects of the hand bones (HP:0009699)1.74465806
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.74465806
161Right ventricular cardiomyopathy (HP:0011663)1.74446904
162Long toe (HP:0010511)1.74415782
163Vertebral clefting (HP:0008428)1.72928850
164Intestinal polyposis (HP:0200008)1.71579505
165Polyneuropathy (HP:0001271)1.70639072
166Recurrent pneumonia (HP:0006532)1.70513403
167Thin bony cortex (HP:0002753)1.70173292
168Stomach cancer (HP:0012126)1.70045622
169Striae distensae (HP:0001065)1.69750850
170Milia (HP:0001056)1.69152874
171Verrucae (HP:0200043)1.69085122
172Papilloma (HP:0012740)1.69085122
173Abnormal pancreas size (HP:0012094)1.69018457
174Hypoplastic labia majora (HP:0000059)1.68716606
175Severe short stature (HP:0003510)1.68699497
176Inflammation of the large intestine (HP:0002037)1.67742525
177Male infertility (HP:0003251)1.67442959
178Transitional cell carcinoma of the bladder (HP:0006740)1.67080816
179Radial bowing (HP:0002986)1.66494906
180Hypopigmentation of the fundus (HP:0007894)1.66402737
181Abdominal distention (HP:0003270)1.65889732
182Shallow orbits (HP:0000586)1.65025877
183Gout (HP:0001997)1.64776872
184Abnormality of T cell physiology (HP:0011840)1.62906919
185Joint swelling (HP:0001386)1.62725362
186Autoimmune thrombocytopenia (HP:0001973)1.62075599
187Facial diplegia (HP:0001349)1.58244976
188Cutaneous melanoma (HP:0012056)1.56119724
189Slow saccadic eye movements (HP:0000514)1.56070028
190Glomerulopathy (HP:0100820)1.56037588
191Increased CSF protein (HP:0002922)1.55677369
192Pruritus (HP:0000989)1.54365350
193Abnormality of the pleura (HP:0002103)1.54034110
194Atrophy/Degeneration involving motor neurons (HP:0007373)1.51785103
195Chronic obstructive pulmonary disease (HP:0006510)1.50604170
196Obstructive lung disease (HP:0006536)1.50604170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.04459515
2PKN23.40382090
3MAP3K143.32181132
4TRIB33.22648620
5FRK3.19126601
6TXK2.90798118
7FLT32.71692969
8RIPK42.70999391
9MAP3K22.69966799
10SCYL22.42094599
11BRD42.40794818
12MAP3K122.29311408
13BLK2.29097404
14PTK62.20744359
15TAOK32.19033244
16SIK32.10684967
17EEF2K2.09210476
18IKBKE2.02391987
19STK31.99734146
20KSR21.97623333
21JAK11.94268231
22TYK21.93089294
23IRAK41.91956064
24PRKD31.91348671
25EPHA31.91141573
26CSK1.89017156
27FES1.85489289
28RET1.77794713
29MST41.76068071
30STK101.72242799
31MOS1.69682549
32NLK1.68579079
33MAP4K11.66648535
34LRRK21.62300568
35MELK1.59185412
36YES11.57742467
37CAMKK21.55720131
38STK38L1.52789925
39MAP3K31.51272661
40MAP3K91.50839096
41ERBB31.49299578
42MAP3K101.46109606
43TEC1.44265777
44MAP3K41.40910680
45ERBB41.40182255
46IKBKB1.37546943
47CAMKK11.36674306
48IRAK11.33254691
49TAOK11.32776767
50FGFR21.30068450
51SIK11.30002270
52TBK11.29130763
53PRPF4B1.25439810
54LCK1.25382593
55ZAP701.24955742
56BTK1.24487162
57GRK71.24378126
58TGFBR11.23919682
59PDGFRA1.22406523
60CDK61.21554717
61LATS21.21313679
62PIK3CG1.20463436
63SYK1.20276418
64LYN1.19538136
65MET1.18322462
66MATK1.13981163
67KSR11.13456117
68STK241.11622650
69MAP3K81.09843626
70MARK31.07895090
71ALK1.07081718
72BMPR21.05557466
73CAMK1D1.05348191
74HCK1.04759160
75MAP3K61.04055659
76HIPK21.03314280
77PTK21.02441791
78ERN11.00032751
79AKT30.99332956
80FGR0.98450538
81ADRBK20.95480875
82PASK0.90509363
83TRIM280.90210879
84KIT0.89325942
85MAP4K20.88734779
86NUAK10.86444542
87EPHB10.84841878
88PDGFRB0.84592718
89CLK10.84106298
90TGFBR20.83317978
91TTN0.82207844
92CSF1R0.80477474
93IRAK20.80372013
94RIPK10.80072467
95CDK90.80045263
96FGFR10.79873910
97MST1R0.79688678
98FGFR30.79528036
99SRPK10.79242322
100MKNK20.79210906
101EPHA40.78870854
102PRKCH0.78257448
103PIM10.77795625
104DDR20.77532423
105PLK20.77036027
106JAK20.76315299
107MAP2K40.76110595
108PIK3CA0.75124352
109BCR0.72113103
110CDK120.71248788
111MAP3K50.71200960
112PRKCQ0.70400840
113MAP2K30.70288285
114FER0.69444249
115JAK30.69125148
116TYRO30.69045451
117RPS6KB20.68954433
118CHUK0.68498620
119BMPR1B0.64715212
120RPS6KA40.62224271
121GRK60.60488931
122WNK10.60313983
123WNK30.59776174
124ACVR1B0.58139537
125SGK20.55389729
126MAPK70.55204072
127EIF2AK30.54982197
128SGK30.53864561
129MAP3K70.53422069
130RAF10.52233006
131NTRK10.51439884
132CSNK1G20.51088564
133PAK60.50261954
134EPHA20.50085407
135MAP3K130.49922051
136PDK10.48094429
137MKNK10.47987835
138CDK40.46952682
139MAP3K10.46108287
140ABL10.45249379
141NEK90.43911088
142FYN0.43901711
143RPS6KB10.43634596
144MAP2K10.43223805
145MTOR0.42907482
146CSNK1G10.41772688
147STK380.39583626
148CDC70.38300049
149EGFR0.38111399
150CDK80.37518971
151ITK0.37334528
152INSRR0.36984678
153PAK30.36893624
154TTK0.36299244
155TRPM70.36131975
156BRSK20.36080444
157EIF2AK20.34100163
158PDPK10.34025329
159IGF1R0.33822630
160PAK20.33075658
161DYRK30.32973824
162DAPK20.32827024
163MAPK110.32800196

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.65376327
2Nitrogen metabolism_Homo sapiens_hsa009103.13792566
3Leishmaniasis_Homo sapiens_hsa051402.53332100
4Sulfur metabolism_Homo sapiens_hsa009202.52142085
5Non-homologous end-joining_Homo sapiens_hsa034502.48184136
6Osteoclast differentiation_Homo sapiens_hsa043802.46617826
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.44785002
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.44641061
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.15458153
10T cell receptor signaling pathway_Homo sapiens_hsa046602.14069737
11mTOR signaling pathway_Homo sapiens_hsa041502.13011129
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11586169
13Graft-versus-host disease_Homo sapiens_hsa053322.11059009
14Allograft rejection_Homo sapiens_hsa053302.10230039
15Legionellosis_Homo sapiens_hsa051342.09723120
16Hematopoietic cell lineage_Homo sapiens_hsa046402.03613514
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03444629
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03060484
19Measles_Homo sapiens_hsa051622.01421985
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96621307
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95645237
22Tuberculosis_Homo sapiens_hsa051521.93996543
23Autoimmune thyroid disease_Homo sapiens_hsa053201.92198712
24Type I diabetes mellitus_Homo sapiens_hsa049401.84250710
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.66141103
26TNF signaling pathway_Homo sapiens_hsa046681.56606686
27Rheumatoid arthritis_Homo sapiens_hsa053231.54819283
28Staphylococcus aureus infection_Homo sapiens_hsa051501.52895606
29Selenocompound metabolism_Homo sapiens_hsa004501.52192549
30Malaria_Homo sapiens_hsa051441.49779206
31Antigen processing and presentation_Homo sapiens_hsa046121.43874061
32Endometrial cancer_Homo sapiens_hsa052131.43021109
33Herpes simplex infection_Homo sapiens_hsa051681.41603964
34Hepatitis B_Homo sapiens_hsa051611.40357823
35Dorso-ventral axis formation_Homo sapiens_hsa043201.39223266
36Pancreatic cancer_Homo sapiens_hsa052121.39000277
37Protein export_Homo sapiens_hsa030601.38687195
38Shigellosis_Homo sapiens_hsa051311.38120560
39Arginine biosynthesis_Homo sapiens_hsa002201.36831192
40Adherens junction_Homo sapiens_hsa045201.35445670
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35244481
42Long-term potentiation_Homo sapiens_hsa047201.33067293
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31952168
44Insulin resistance_Homo sapiens_hsa049311.31429389
45Non-small cell lung cancer_Homo sapiens_hsa052231.30319856
46Influenza A_Homo sapiens_hsa051641.30219787
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29552991
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.25727298
49Glioma_Homo sapiens_hsa052141.25607904
50Chronic myeloid leukemia_Homo sapiens_hsa052201.24967771
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24638392
52Chemokine signaling pathway_Homo sapiens_hsa040621.23084503
53Asthma_Homo sapiens_hsa053101.22638454
54N-Glycan biosynthesis_Homo sapiens_hsa005101.21187676
55Fatty acid biosynthesis_Homo sapiens_hsa000611.20974842
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20917601
57Viral myocarditis_Homo sapiens_hsa054161.20579318
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19518330
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17075526
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17036442
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16322042
62Proteoglycans in cancer_Homo sapiens_hsa052051.16094895
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14066511
64Type II diabetes mellitus_Homo sapiens_hsa049301.13267739
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12957413
66Thyroid cancer_Homo sapiens_hsa052161.12005166
67Pancreatic secretion_Homo sapiens_hsa049721.11722100
68Central carbon metabolism in cancer_Homo sapiens_hsa052301.11398024
69VEGF signaling pathway_Homo sapiens_hsa043701.11304025
70Regulation of autophagy_Homo sapiens_hsa041401.11170710
71Estrogen signaling pathway_Homo sapiens_hsa049151.10835262
72Bladder cancer_Homo sapiens_hsa052191.09972102
73Hepatitis C_Homo sapiens_hsa051601.09559661
74Focal adhesion_Homo sapiens_hsa045101.08935990
75GnRH signaling pathway_Homo sapiens_hsa049121.07171733
76Renal cell carcinoma_Homo sapiens_hsa052111.06852648
77Phagosome_Homo sapiens_hsa041451.06673346
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05925159
79Bile secretion_Homo sapiens_hsa049761.04980782
80Pertussis_Homo sapiens_hsa051331.03864391
81Small cell lung cancer_Homo sapiens_hsa052221.03034367
82Colorectal cancer_Homo sapiens_hsa052101.02511466
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00206699
84Lysosome_Homo sapiens_hsa041420.98025971
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.97767852
86Thyroid hormone synthesis_Homo sapiens_hsa049180.96167908
87Prolactin signaling pathway_Homo sapiens_hsa049170.95702561
88TGF-beta signaling pathway_Homo sapiens_hsa043500.94989937
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94052813
90ErbB signaling pathway_Homo sapiens_hsa040120.92975250
91Protein digestion and absorption_Homo sapiens_hsa049740.91825302
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91796269
93Salmonella infection_Homo sapiens_hsa051320.91455561
94Circadian rhythm_Homo sapiens_hsa047100.90820556
95Fat digestion and absorption_Homo sapiens_hsa049750.90487548
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89447637
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89324448
98ECM-receptor interaction_Homo sapiens_hsa045120.88340257
99MicroRNAs in cancer_Homo sapiens_hsa052060.87748847
100Hippo signaling pathway_Homo sapiens_hsa043900.87703934
101Collecting duct acid secretion_Homo sapiens_hsa049660.86148028
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.85793954
103AMPK signaling pathway_Homo sapiens_hsa041520.85273151
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84206819
105Insulin signaling pathway_Homo sapiens_hsa049100.84043132
106Prostate cancer_Homo sapiens_hsa052150.83096752
107FoxO signaling pathway_Homo sapiens_hsa040680.82107307
108Apoptosis_Homo sapiens_hsa042100.81171374
109Inositol phosphate metabolism_Homo sapiens_hsa005620.80265192
110Choline metabolism in cancer_Homo sapiens_hsa052310.78734335
111Glucagon signaling pathway_Homo sapiens_hsa049220.78666332
112Epstein-Barr virus infection_Homo sapiens_hsa051690.78196153
113African trypanosomiasis_Homo sapiens_hsa051430.75168778
114Viral carcinogenesis_Homo sapiens_hsa052030.74550090
115Other glycan degradation_Homo sapiens_hsa005110.73414980
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73031738
117Insulin secretion_Homo sapiens_hsa049110.72033289
118Gastric acid secretion_Homo sapiens_hsa049710.71359935
119Tight junction_Homo sapiens_hsa045300.70845656
120Caffeine metabolism_Homo sapiens_hsa002320.69376981
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.67131385
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66339229
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.65381336
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64941920
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64523023
126Oocyte meiosis_Homo sapiens_hsa041140.64024129
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63604943
128Toxoplasmosis_Homo sapiens_hsa051450.63393018
129One carbon pool by folate_Homo sapiens_hsa006700.62906280
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.62451864
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62335414
132Acute myeloid leukemia_Homo sapiens_hsa052210.62159643
133Amoebiasis_Homo sapiens_hsa051460.61706500
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61081909
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61058630
136Platelet activation_Homo sapiens_hsa046110.60926998
137Salivary secretion_Homo sapiens_hsa049700.59823830
138p53 signaling pathway_Homo sapiens_hsa041150.58095132
139Ovarian steroidogenesis_Homo sapiens_hsa049130.55788904
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.55321699
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54751103
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54268887
143B cell receptor signaling pathway_Homo sapiens_hsa046620.54144656
144Complement and coagulation cascades_Homo sapiens_hsa046100.53051279
145Long-term depression_Homo sapiens_hsa047300.52928358
146Fatty acid degradation_Homo sapiens_hsa000710.52174691
147HTLV-I infection_Homo sapiens_hsa051660.51557391
148Oxytocin signaling pathway_Homo sapiens_hsa049210.51259403
149Systemic lupus erythematosus_Homo sapiens_hsa053220.51088587
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51020996
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49529980
152Dopaminergic synapse_Homo sapiens_hsa047280.47161432
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47041051
154Lysine degradation_Homo sapiens_hsa003100.46553184
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46461345
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46367776
157cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46298393
158Endocytosis_Homo sapiens_hsa041440.46090131
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.46066308
160Rap1 signaling pathway_Homo sapiens_hsa040150.45528450
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44316486
162Melanogenesis_Homo sapiens_hsa049160.44003781
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34541041
164Renin-angiotensin system_Homo sapiens_hsa046140.31044928
165Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30299060
166HIF-1 signaling pathway_Homo sapiens_hsa040660.27468376
167Sphingolipid metabolism_Homo sapiens_hsa006000.26938130

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