ABHD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.61911098
2ribosomal small subunit assembly (GO:0000028)5.48979436
3axonemal dynein complex assembly (GO:0070286)5.38877082
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.01662526
5viral transcription (GO:0019083)4.80903624
6calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.75633543
7oxidative phosphorylation (GO:0006119)4.69522523
8translational termination (GO:0006415)4.64615195
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47629612
10ATP synthesis coupled proton transport (GO:0015986)4.47629612
11epithelial cilium movement (GO:0003351)4.35982886
12maturation of SSU-rRNA (GO:0030490)4.35360024
13translational elongation (GO:0006414)4.34157968
14ribosomal small subunit biogenesis (GO:0042274)4.33273353
15cilium movement (GO:0003341)4.28225086
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.24030563
17cotranslational protein targeting to membrane (GO:0006613)4.14094520
18protein targeting to ER (GO:0045047)4.10826852
19protein localization to endoplasmic reticulum (GO:0070972)3.98442805
20nucleobase biosynthetic process (GO:0046112)3.89809480
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.87473928
22behavioral response to nicotine (GO:0035095)3.84166167
23purine nucleobase biosynthetic process (GO:0009113)3.82754580
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.79957559
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.79957559
26proteasome assembly (GO:0043248)3.78576329
27translational initiation (GO:0006413)3.73829207
28axoneme assembly (GO:0035082)3.71062438
29respiratory electron transport chain (GO:0022904)3.69202590
30viral life cycle (GO:0019058)3.64712297
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64005096
32motile cilium assembly (GO:0044458)3.63387188
33electron transport chain (GO:0022900)3.61489424
34ribosomal large subunit biogenesis (GO:0042273)3.61100905
35cilium or flagellum-dependent cell motility (GO:0001539)3.60743356
36negative regulation of T cell differentiation in thymus (GO:0033085)3.57185189
37cellular protein complex disassembly (GO:0043624)3.56563479
38translation (GO:0006412)3.51208916
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48485568
40formation of translation preinitiation complex (GO:0001731)3.48008946
41telomere maintenance via semi-conservative replication (GO:0032201)3.45151350
42GDP-mannose metabolic process (GO:0019673)3.43760507
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43161645
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.42521712
45NADH dehydrogenase complex assembly (GO:0010257)3.42521712
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42521712
47ribonucleoprotein complex biogenesis (GO:0022613)3.37588355
48pseudouridine synthesis (GO:0001522)3.37496970
49regulation of cell proliferation involved in kidney development (GO:1901722)3.36211742
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35093630
51GTP biosynthetic process (GO:0006183)3.34320694
52respiratory chain complex IV assembly (GO:0008535)3.33597244
53primary alcohol catabolic process (GO:0034310)3.32692623
54folic acid metabolic process (GO:0046655)3.32343676
55intestinal epithelial cell development (GO:0060576)3.30962061
56DNA strand elongation involved in DNA replication (GO:0006271)3.30918954
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30822175
58preassembly of GPI anchor in ER membrane (GO:0016254)3.29566991
59keratinocyte development (GO:0003334)3.26984080
60nucleoside transmembrane transport (GO:1901642)3.25451293
61iron-sulfur cluster assembly (GO:0016226)3.25298972
62metallo-sulfur cluster assembly (GO:0031163)3.25298972
63protein-cofactor linkage (GO:0018065)3.25015068
64regulation of mitochondrial translation (GO:0070129)3.22566995
65cornea development in camera-type eye (GO:0061303)3.21892128
66protein complex biogenesis (GO:0070271)3.19880243
67amino acid salvage (GO:0043102)3.18693634
68L-methionine salvage (GO:0071267)3.18693634
69L-methionine biosynthetic process (GO:0071265)3.18693634
70cellular component biogenesis (GO:0044085)3.18169570
71ubiquinone biosynthetic process (GO:0006744)3.17757417
72quinone biosynthetic process (GO:1901663)3.17757417
73DNA strand elongation (GO:0022616)3.16194657
74mitochondrial respiratory chain complex assembly (GO:0033108)3.15820679
75sulfur amino acid catabolic process (GO:0000098)3.15490646
76aerobic respiration (GO:0009060)3.14752834
77NADH metabolic process (GO:0006734)3.13700089
78base-excision repair, AP site formation (GO:0006285)3.13631183
79water-soluble vitamin biosynthetic process (GO:0042364)3.09627881
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.07143755
81termination of RNA polymerase III transcription (GO:0006386)3.07143755
82cellular ketone body metabolic process (GO:0046950)3.06698728
83galactose catabolic process (GO:0019388)3.05361975
84regulation of cellular amino acid metabolic process (GO:0006521)3.05346994
85tricarboxylic acid cycle (GO:0006099)3.03672038
86desmosome organization (GO:0002934)3.02714960
87protein complex disassembly (GO:0043241)3.01782814
88inner mitochondrial membrane organization (GO:0007007)3.01681414
89nitric oxide biosynthetic process (GO:0006809)2.99988381
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99760270
91ribosome biogenesis (GO:0042254)2.99181199
92nucleoside diphosphate phosphorylation (GO:0006165)2.99010159
93rRNA modification (GO:0000154)2.98731117
94trivalent inorganic anion homeostasis (GO:0072506)2.97969326
95phosphate ion homeostasis (GO:0055062)2.97969326
96peptidyl-histidine modification (GO:0018202)2.97717551
97establishment of protein localization to mitochondrial membrane (GO:0090151)2.95672910
98branched-chain amino acid catabolic process (GO:0009083)2.95173712
99chaperone-mediated protein transport (GO:0072321)2.94669772
100glycine metabolic process (GO:0006544)2.91651067
101nucleoside salvage (GO:0043174)2.91126522
102negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90821891
103rRNA processing (GO:0006364)2.90374693
104macromolecular complex disassembly (GO:0032984)2.90229294
105UTP biosynthetic process (GO:0006228)2.89362593
106protein localization to cilium (GO:0061512)2.87934015
107telomere maintenance via recombination (GO:0000722)2.87550790
108mesonephros development (GO:0001823)2.86559592
109tRNA modification (GO:0006400)2.86086234
110nucleobase-containing small molecule interconversion (GO:0015949)2.85704893
111ear development (GO:0043583)2.85452773
112pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84485081
113C-terminal protein lipidation (GO:0006501)2.84333931
114protein targeting to mitochondrion (GO:0006626)2.82407550
115pteridine-containing compound biosynthetic process (GO:0042559)2.82358262
116valine metabolic process (GO:0006573)2.80886651
117regulation of autophagic vacuole assembly (GO:2000785)2.80003782
118ATP biosynthetic process (GO:0006754)2.79731533
119GPI anchor biosynthetic process (GO:0006506)2.79165414
120rRNA metabolic process (GO:0016072)2.79072648
121regulation of cellular respiration (GO:0043457)2.78570117
122vitamin transmembrane transport (GO:0035461)2.78131562
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77480682
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76186235
125establishment of protein localization to mitochondrion (GO:0072655)2.75889597
126L-phenylalanine metabolic process (GO:0006558)2.75848646
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75848646
128mannosylation (GO:0097502)2.75491818
129purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.75355780
130purine nucleoside monophosphate biosynthetic process (GO:0009127)2.75355780
131hydrogen ion transmembrane transport (GO:1902600)2.75003298
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74932468
133negative regulation of ligase activity (GO:0051352)2.74932468
134cytochrome complex assembly (GO:0017004)2.74377314
135serine family amino acid biosynthetic process (GO:0009070)2.74163540
136purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73411705
137ubiquinone metabolic process (GO:0006743)2.72712795
138ketone body metabolic process (GO:1902224)2.72393973
139ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72078908
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71099161
141tRNA processing (GO:0008033)2.70664774
142fucose catabolic process (GO:0019317)2.70262576
143L-fucose metabolic process (GO:0042354)2.70262576
144L-fucose catabolic process (GO:0042355)2.70262576
145nucleoside monophosphate biosynthetic process (GO:0009124)2.70027999
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69889835
147signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69889835
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69800327
149proton transport (GO:0015992)2.69779472
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69507123
151regulation of cilium movement (GO:0003352)2.69438268
152cysteine metabolic process (GO:0006534)2.68108173
153left/right pattern formation (GO:0060972)2.68103607
154glutathione derivative biosynthetic process (GO:1901687)2.67349329
155glutathione derivative metabolic process (GO:1901685)2.67349329
156aldehyde catabolic process (GO:0046185)2.66157730
157UTP metabolic process (GO:0046051)2.64677000
158negative regulation of kidney development (GO:0090185)2.63945462
159GPI anchor metabolic process (GO:0006505)2.62258677
160pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62027336
161hydrogen transport (GO:0006818)2.61184581
162response to food (GO:0032094)2.60404170
163glutathione biosynthetic process (GO:0006750)2.59673212
164galactose metabolic process (GO:0006012)2.59431559
165nucleoside transport (GO:0015858)2.58155357
166intraciliary transport (GO:0042073)2.56305825
167terpenoid biosynthetic process (GO:0016114)2.55285120
168C-terminal protein amino acid modification (GO:0018410)2.54630202
169pyrimidine-containing compound transmembrane transport (GO:0072531)2.53823936
170multicellular organism reproduction (GO:0032504)2.52193305
171rRNA methylation (GO:0031167)2.50611263
172diterpenoid biosynthetic process (GO:0016102)2.49008486
173platelet dense granule organization (GO:0060155)2.47636788
174guanosine-containing compound biosynthetic process (GO:1901070)2.46977975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.71627411
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.15139215
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09254337
4E2F7_22180533_ChIP-Seq_HELA_Human3.90247380
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50979401
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45871785
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.22217894
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10833856
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.06049352
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05192082
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03124453
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.98658873
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97796436
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.76993536
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76758797
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75842402
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62290153
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58552549
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53165297
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.51978848
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50180012
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.39692658
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.39232637
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.26895147
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26264594
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.24699784
27* XRN2_22483619_ChIP-Seq_HELA_Human2.24283046
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22110855
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18541431
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16267737
31VDR_23849224_ChIP-Seq_CD4+_Human2.15901383
32DCP1A_22483619_ChIP-Seq_HELA_Human2.10171693
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08115690
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99229776
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.97516551
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.97388873
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95838308
38FOXP3_21729870_ChIP-Seq_TREG_Human1.93168227
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92621181
40* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91397686
41ZNF274_21170338_ChIP-Seq_K562_Hela1.89635882
42GABP_19822575_ChIP-Seq_HepG2_Human1.86802356
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84511712
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82249138
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77269619
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.74899737
47VDR_22108803_ChIP-Seq_LS180_Human1.73757316
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72580756
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71985432
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69193799
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66891636
52* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63939719
53TTF2_22483619_ChIP-Seq_HELA_Human1.62778792
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61360000
55ERA_21632823_ChIP-Seq_H3396_Human1.60198799
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.58015111
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57369973
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55112340
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54466648
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53513224
61P68_20966046_ChIP-Seq_HELA_Human1.52791323
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52186227
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50736026
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50631620
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50481821
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48541719
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.48161647
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45152012
69* CDX2_20551321_ChIP-Seq_CACO-2_Human1.44347626
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44075480
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43206871
72ELF5_23300383_ChIP-Seq_T47D_Human1.40638757
73* HOXB7_26014856_ChIP-Seq_BT474_Human1.40359124
74* FOXP1_21924763_ChIP-Seq_HESCs_Human1.38131552
75PHF8_20622854_ChIP-Seq_HELA_Human1.37615395
76* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37419379
77CTCF_20526341_ChIP-Seq_ESCs_Human1.33859748
78E2F1_20622854_ChIP-Seq_HELA_Human1.33543525
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32362371
80CIITA_25753668_ChIP-Seq_RAJI_Human1.31743543
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31131393
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31068747
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29786335
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29533215
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27945255
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27478298
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25321962
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24192912
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23694725
90* GATA3_24758297_ChIP-Seq_MCF-7_Human1.23548373
91* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22233928
92AR_21909140_ChIP-Seq_LNCAP_Human1.20925416
93STAT1_20625510_ChIP-Seq_HELA_Human1.20701963
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19315364
95* BCOR_27268052_Chip-Seq_Bcells_Human1.18994607
96GATA6_25053715_ChIP-Seq_YYC3_Human1.18158846
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18137304
98CTCF_27219007_Chip-Seq_Bcells_Human1.16066038
99* BCL6_27268052_Chip-Seq_Bcells_Human1.16043036
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15110235
101GATA4_25053715_ChIP-Seq_YYC3_Human1.14460790
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13842479
103NANOG_20526341_ChIP-Seq_ESCs_Human1.13752150
104P53_21459846_ChIP-Seq_SAOS-2_Human1.13571970
105* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12979703
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12835632
107* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10508292
108ELK1_19687146_ChIP-ChIP_HELA_Human1.10243675
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09896518
110RARB_24833708_ChIP-Seq_LIVER_Mouse1.09791256
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09218458
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09068787
113* P300_27268052_Chip-Seq_Bcells_Human1.08805565
114KDM5A_27292631_Chip-Seq_BREAST_Human1.07374029
115ZNF263_19887448_ChIP-Seq_K562_Human1.07015704
116SMC4_20622854_ChIP-Seq_HELA_Human1.06747019
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06431309
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06181042
119OCT4_20526341_ChIP-Seq_ESCs_Human1.05002450
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.04898830
121LXR_22292898_ChIP-Seq_THP-1_Human1.04865740
122TAF2_19829295_ChIP-Seq_ESCs_Human1.04525739
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.04256363
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04256363
125VDR_21846776_ChIP-Seq_THP-1_Human1.03214099
126CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02995024
127RAC3_21632823_ChIP-Seq_H3396_Human1.02620545
128ELK1_22589737_ChIP-Seq_MCF10A_Human1.02610855
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02529840
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.01409377
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01022588
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.00850589
133TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00691178
134SPI1_23547873_ChIP-Seq_NB4_Human1.00589128
135IRF1_19129219_ChIP-ChIP_H3396_Human1.00480987
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00131703
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.99840706
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99836412
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97281772
140AHR_22903824_ChIP-Seq_MCF-7_Human0.96439349
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96167198
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96061872
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95646887
144TP53_22573176_ChIP-Seq_HFKS_Human0.95419367
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95370806
146AR_20517297_ChIP-Seq_VCAP_Human0.94530378
147* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94327029
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93659154
149MYC_22102868_ChIP-Seq_BL_Human0.93254410
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92737168
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92382622
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.89960150
153GATA1_22025678_ChIP-Seq_K562_Human0.88727934
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88469490
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88396249
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87986404
157OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86661095
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85965509
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85739461
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.83502774
161* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83154510
162FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83123922
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83044175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.88282249
2MP0003693_abnormal_embryo_hatching3.94914255
3MP0002139_abnormal_hepatobiliary_system3.41436834
4MP0005360_urolithiasis3.33405844
5MP0006036_abnormal_mitochondrial_physio3.26824272
6MP0005085_abnormal_gallbladder_physiolo3.06959081
7MP0005365_abnormal_bile_salt3.06100065
8MP0008875_abnormal_xenobiotic_pharmacok3.00513326
9MP0009780_abnormal_chondrocyte_physiolo2.68883778
10MP0003186_abnormal_redox_activity2.68616308
11MP0004957_abnormal_blastocyst_morpholog2.55396388
12MP0009379_abnormal_foot_pigmentation2.53077890
13MP0002160_abnormal_reproductive_system2.52819514
14MP0003646_muscle_fatigue2.48553156
15MP0004043_abnormal_pH_regulation2.23153731
16MP0009840_abnormal_foam_cell2.22021484
17MP0002396_abnormal_hematopoietic_system2.20544244
18MP0001764_abnormal_homeostasis2.18175234
19MP0005332_abnormal_amino_acid2.16056082
20MP0002876_abnormal_thyroid_physiology2.15939035
21MP0002277_abnormal_respiratory_mucosa2.09635307
22MP0006035_abnormal_mitochondrial_morpho2.06791157
23MP0002098_abnormal_vibrissa_morphology2.06567735
24MP0002653_abnormal_ependyma_morphology1.98821461
25MP0010030_abnormal_orbit_morphology1.97776778
26MP0005646_abnormal_pituitary_gland1.96148353
27MP0005377_hearing/vestibular/ear_phenot1.93081693
28MP0003878_abnormal_ear_physiology1.93081693
29MP0002736_abnormal_nociception_after1.90754922
30MP0001873_stomach_inflammation1.89773556
31MP0005083_abnormal_biliary_tract1.85933538
32MP0010094_abnormal_chromosome_stability1.85685032
33MP0001666_abnormal_nutrient_absorption1.82217763
34MP0000383_abnormal_hair_follicle1.81518677
35MP0000490_abnormal_crypts_of1.78497949
36MP0000427_abnormal_hair_cycle1.78430924
37MP0003718_maternal_effect1.74605661
38MP0001853_heart_inflammation1.72226707
39MP0010234_abnormal_vibrissa_follicle1.70651128
40MP0008058_abnormal_DNA_repair1.70001188
41MP0002909_abnormal_adrenal_gland1.69705540
42MP0003191_abnormal_cellular_cholesterol1.67875809
43MP0004133_heterotaxia1.66522327
44MP0010329_abnormal_lipoprotein_level1.64373164
45MP0008057_abnormal_DNA_replication1.64154629
46MP0008995_early_reproductive_senescence1.63796453
47MP0003656_abnormal_erythrocyte_physiolo1.63591829
48MP0005389_reproductive_system_phenotype1.63186368
49MP0003077_abnormal_cell_cycle1.62773772
50MP0003123_paternal_imprinting1.59313748
51MP0005319_abnormal_enzyme/_coenzyme1.58110975
52MP0003136_yellow_coat_color1.52201113
53MP0001485_abnormal_pinna_reflex1.52188762
54MP0003111_abnormal_nucleus_morphology1.51955126
55MP0009643_abnormal_urine_homeostasis1.50809394
56MP0002938_white_spotting1.46574442
57MP0005266_abnormal_metabolism1.45941808
58MP0001765_abnormal_ion_homeostasis1.44753433
59MP0002249_abnormal_larynx_morphology1.44480272
60MP0002132_abnormal_respiratory_system1.44158675
61MP0010678_abnormal_skin_adnexa1.39291594
62MP0000372_irregular_coat_pigmentation1.38902800
63MP0005584_abnormal_enzyme/coenzyme_acti1.38630223
64MP0005075_abnormal_melanosome_morpholog1.37799685
65MP0005636_abnormal_mineral_homeostasis1.36690237
66MP0005408_hypopigmentation1.35056931
67MP0004019_abnormal_vitamin_homeostasis1.34171239
68MP0004147_increased_porphyrin_level1.31703716
69MP0001968_abnormal_touch/_nociception1.31412598
70MP0002837_dystrophic_cardiac_calcinosis1.31354095
71MP0003183_abnormal_peptide_metabolism1.31314321
72MP0003787_abnormal_imprinting1.29379740
73MP0001919_abnormal_reproductive_system1.28726139
74MP0001664_abnormal_digestion1.27529259
75MP0003763_abnormal_thymus_physiology1.24474952
76MP0009333_abnormal_splenocyte_physiolog1.24328757
77MP0000538_abnormal_urinary_bladder1.23396284
78MP0003724_increased_susceptibility_to1.22417444
79MP0003786_premature_aging1.20185485
80MP0003567_abnormal_fetal_cardiomyocyte1.19964739
81MP0003938_abnormal_ear_development1.19632128
82MP0000647_abnormal_sebaceous_gland1.19243133
83MP0005330_cardiomyopathy1.18986472
84MP0000609_abnormal_liver_physiology1.18697167
85MP0009785_altered_susceptibility_to1.18325568
86MP0002796_impaired_skin_barrier1.17657280
87MP0005551_abnormal_eye_electrophysiolog1.16802571
88MP0001545_abnormal_hematopoietic_system1.16696198
89MP0005397_hematopoietic_system_phenotyp1.16696198
90MP0003879_abnormal_hair_cell1.15703164
91MP0001502_abnormal_circadian_rhythm1.15543951
92MP0005645_abnormal_hypothalamus_physiol1.15275484
93MP0006292_abnormal_olfactory_placode1.13959606
94MP0005376_homeostasis/metabolism_phenot1.13609883
95MP0003195_calcinosis1.13273131
96MP0000358_abnormal_cell_content/1.13223681
97MP0003936_abnormal_reproductive_system1.13219635
98MP0003011_delayed_dark_adaptation1.11651732
99MP0000678_abnormal_parathyroid_gland1.10866125
100MP0002118_abnormal_lipid_homeostasis1.08617218
101MP0003221_abnormal_cardiomyocyte_apopto1.07983043
102MP0001905_abnormal_dopamine_level1.07394830
103MP0005451_abnormal_body_composition1.06620611
104MP0001529_abnormal_vocalization1.06118953
105MP0008932_abnormal_embryonic_tissue1.05516091
106MP0010386_abnormal_urinary_bladder1.03383014
107MP0000566_synostosis1.02263276
108MP0008469_abnormal_protein_level1.01358907
109MP0005410_abnormal_fertilization0.99182818
110MP0009697_abnormal_copulation0.99017860
111MP0000026_abnormal_inner_ear0.97485785
112MP0001881_abnormal_mammary_gland0.97426381
113MP0002254_reproductive_system_inflammat0.97335983
114MP0008007_abnormal_cellular_replicative0.96875272
115MP0003866_abnormal_defecation0.96467216
116MP0000598_abnormal_liver_morphology0.93958261
117MP0001944_abnormal_pancreas_morphology0.93732606
118MP0001756_abnormal_urination0.90339055
119MP0002269_muscular_atrophy0.90179031
120MP0002019_abnormal_tumor_incidence0.86957255
121MP0006054_spinal_hemorrhage0.86941736
122MP0002163_abnormal_gland_morphology0.86428867
123MP0004782_abnormal_surfactant_physiolog0.85519628
124MP0005670_abnormal_white_adipose0.84938133
125MP0010155_abnormal_intestine_physiology0.84812305
126MP0005464_abnormal_platelet_physiology0.84686939
127MP0005501_abnormal_skin_physiology0.84418167
128MP0000470_abnormal_stomach_morphology0.83033125
129MP0003953_abnormal_hormone_level0.82997057
130MP0000689_abnormal_spleen_morphology0.82881631
131MP0005025_abnormal_response_to0.81812435
132MP0004215_abnormal_myocardial_fiber0.81546425
133MP0000613_abnormal_salivary_gland0.81522812
134MP0002102_abnormal_ear_morphology0.81390089
135MP0000749_muscle_degeneration0.80999385
136MP0005084_abnormal_gallbladder_morpholo0.80933975
137MP0004084_abnormal_cardiac_muscle0.80105927
138MP0008961_abnormal_basal_metabolism0.79854717
139MP0000631_abnormal_neuroendocrine_gland0.79812700
140MP0000467_abnormal_esophagus_morphology0.79620141
141MP0000627_abnormal_mammary_gland0.79536236
142MP0001730_embryonic_growth_arrest0.78546585
143MP0002722_abnormal_immune_system0.78422697
144MP0008872_abnormal_physiological_respon0.77651006
145MP0002693_abnormal_pancreas_physiology0.75518867
146MP0000049_abnormal_middle_ear0.75268311
147MP0002210_abnormal_sex_determination0.74976509
148MP0009642_abnormal_blood_homeostasis0.74538391
149MP0000685_abnormal_immune_system0.73497993
150MP0003942_abnormal_urinary_system0.71870966
151MP0000313_abnormal_cell_death0.71070278
152MP0002429_abnormal_blood_cell0.70970609
153MP0009763_increased_sensitivity_to0.70312474
154MP0000750_abnormal_muscle_regeneration0.69982819
155MP0004036_abnormal_muscle_relaxation0.69777932
156MP0002398_abnormal_bone_marrow0.69435399
157MP0008873_increased_physiological_sensi0.67305837
158MP0000747_muscle_weakness0.66117435
159MP0001845_abnormal_inflammatory_respons0.65237162
160MP0001835_abnormal_antigen_presentation0.65153166
161MP0003436_decreased_susceptibility_to0.63721822
162MP0000858_altered_metastatic_potential0.63576559
163MP0001544_abnormal_cardiovascular_syste0.63218066
164MP0005385_cardiovascular_system_phenoty0.63218066
165MP0004808_abnormal_hematopoietic_stem0.62551016
166MP0004264_abnormal_extraembryonic_tissu0.61755716
167MP0002136_abnormal_kidney_physiology0.60913318
168MP0001663_abnormal_digestive_system0.60401623

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.24638472
2Hepatic necrosis (HP:0002605)5.14231912
3Hepatocellular necrosis (HP:0001404)4.97471337
4Abnormality of cells of the erythroid lineage (HP:0012130)4.74540874
5Abnormal number of erythroid precursors (HP:0012131)4.53236854
6Mitochondrial inheritance (HP:0001427)4.45683609
7Acute necrotizing encephalopathy (HP:0006965)4.44120982
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.40183171
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.40183171
10Abnormal mitochondria in muscle tissue (HP:0008316)4.31485781
11Abnormal respiratory motile cilium physiology (HP:0012261)4.30727123
12Abnormal respiratory motile cilium morphology (HP:0005938)4.28587874
13Abnormal respiratory epithelium morphology (HP:0012253)4.28587874
14Acute encephalopathy (HP:0006846)4.27502304
15Increased CSF lactate (HP:0002490)4.19029150
16Absent/shortened dynein arms (HP:0200106)4.01668891
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.01668891
18Chronic bronchitis (HP:0004469)3.86073183
19Abnormal ciliary motility (HP:0012262)3.79067291
20Rhinitis (HP:0012384)3.73761560
21Cerebral edema (HP:0002181)3.72788154
22Lactic acidosis (HP:0003128)3.69149599
23Increased serum lactate (HP:0002151)3.65095899
24Lipid accumulation in hepatocytes (HP:0006561)3.60585210
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58259915
26Increased muscle lipid content (HP:0009058)3.57518926
27Reticulocytopenia (HP:0001896)3.56351420
28Increased intramyocellular lipid droplets (HP:0012240)3.52299745
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.52076396
30Dicarboxylic aciduria (HP:0003215)3.52076396
31Increased hepatocellular lipid droplets (HP:0006565)3.45785431
32Progressive macrocephaly (HP:0004481)3.45265329
33Concave nail (HP:0001598)3.35579290
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.28705128
35Abnormality of fatty-acid metabolism (HP:0004359)3.24482542
36Lethargy (HP:0001254)3.14552861
37Generalized aminoaciduria (HP:0002909)3.14072312
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11510620
39Pancreatic cysts (HP:0001737)3.09659724
40Chronic hepatic failure (HP:0100626)3.09136415
41Hyperammonemia (HP:0001987)3.04741275
42Macrocytic anemia (HP:0001972)3.04632190
43True hermaphroditism (HP:0010459)3.03319381
443-Methylglutaconic aciduria (HP:0003535)3.02797771
45Aplastic anemia (HP:0001915)3.01995447
46Hyperglycinuria (HP:0003108)3.01812587
47Respiratory failure (HP:0002878)2.93530059
48Renal Fanconi syndrome (HP:0001994)2.93373611
49Exercise intolerance (HP:0003546)2.91928374
50Oral leukoplakia (HP:0002745)2.88839606
51Abnormality of glycolysis (HP:0004366)2.86932709
52Increased serum pyruvate (HP:0003542)2.86932709
53Tubular atrophy (HP:0000092)2.86259678
54Pancreatic fibrosis (HP:0100732)2.86216306
55Birth length less than 3rd percentile (HP:0003561)2.83562534
56Hyperglycinemia (HP:0002154)2.83071416
57Abnormality of glycine metabolism (HP:0010895)2.78397632
58Abnormality of serine family amino acid metabolism (HP:0010894)2.78397632
59CNS demyelination (HP:0007305)2.76669037
60Vascular calcification (HP:0004934)2.75777545
61Abnormality of midbrain morphology (HP:0002418)2.74251105
62Molar tooth sign on MRI (HP:0002419)2.74251105
63Respiratory difficulties (HP:0002880)2.67795689
64Large for gestational age (HP:0001520)2.66847095
65Type I transferrin isoform profile (HP:0003642)2.63229950
66Multiple enchondromatosis (HP:0005701)2.60273805
67Ragged-red muscle fibers (HP:0003200)2.59850241
68Nephronophthisis (HP:0000090)2.59736932
69Rhabdomyolysis (HP:0003201)2.59232598
70Hypobetalipoproteinemia (HP:0003563)2.58942401
71Exertional dyspnea (HP:0002875)2.58503212
72Cystic liver disease (HP:0006706)2.55646594
73Hypoglycemic coma (HP:0001325)2.54688495
74Reduced antithrombin III activity (HP:0001976)2.53707364
75Bronchiectasis (HP:0002110)2.51427197
76Nausea (HP:0002018)2.50310243
77Ketosis (HP:0001946)2.49240298
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47574806
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47210849
80Abnormality of pyrimidine metabolism (HP:0004353)2.47120483
81Pallor (HP:0000980)2.46685581
82Abnormality of urine glucose concentration (HP:0011016)2.46477466
83Glycosuria (HP:0003076)2.46477466
84Methylmalonic aciduria (HP:0012120)2.45349335
85Occipital encephalocele (HP:0002085)2.43911108
86Metabolic acidosis (HP:0001942)2.40492173
87Thrombocytosis (HP:0001894)2.39863560
88Abnormality of serum amino acid levels (HP:0003112)2.36834944
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.32871669
90Emotional lability (HP:0000712)2.32200925
91Vomiting (HP:0002013)2.31151154
92Pancytopenia (HP:0001876)2.31020839
93Palpitations (HP:0001962)2.30408010
94Tubulointerstitial nephritis (HP:0001970)2.27988218
95Microvesicular hepatic steatosis (HP:0001414)2.26676658
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26116455
97Abnormality of alanine metabolism (HP:0010916)2.25485768
98Hyperalaninemia (HP:0003348)2.25485768
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25485768
100Proximal tubulopathy (HP:0000114)2.24427978
101Pendular nystagmus (HP:0012043)2.22179509
102Hyperlipoproteinemia (HP:0010980)2.13794521
103Progressive muscle weakness (HP:0003323)2.11678370
104Abnormality of the renal medulla (HP:0100957)2.11070056
105Cardiovascular calcification (HP:0011915)2.09095584
106Male pseudohermaphroditism (HP:0000037)2.09017273
107Hyperphosphatemia (HP:0002905)2.07735522
108Hyperthyroidism (HP:0000836)2.07521699
109Decreased circulating renin level (HP:0003351)2.07518463
110Hyperactive renin-angiotensin system (HP:0000841)2.07173255
111Sclerocornea (HP:0000647)2.06314331
112Intrahepatic cholestasis (HP:0001406)2.05802454
113Myoglobinuria (HP:0002913)2.03863838
114Microretrognathia (HP:0000308)2.03827019
115Petechiae (HP:0000967)2.03582954
116Aplasia/hypoplasia of the uterus (HP:0008684)2.03492754
117Abnormal rod and cone electroretinograms (HP:0008323)2.00723239
118Testicular atrophy (HP:0000029)2.00600921
119Abnormal urine phosphate concentration (HP:0012599)1.98606802
120Gliosis (HP:0002171)1.97587857
121Ketoacidosis (HP:0001993)1.97321595
122Abnormality of renal resorption (HP:0011038)1.97235814
123Leukodystrophy (HP:0002415)1.96918745
124Optic disc pallor (HP:0000543)1.94650832
125Type II lissencephaly (HP:0007260)1.93960596
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93192230
127Abnormal protein N-linked glycosylation (HP:0012347)1.93192230
128Abnormal protein glycosylation (HP:0012346)1.93192230
129Abnormal glycosylation (HP:0012345)1.93192230
130Methylmalonic acidemia (HP:0002912)1.92632895
131Cerebral hypomyelination (HP:0006808)1.92329417
132Amelogenesis imperfecta (HP:0000705)1.91968099
133Gout (HP:0001997)1.91717180
134Polydipsia (HP:0001959)1.91190265
135Abnormal drinking behavior (HP:0030082)1.91190265
136Pili torti (HP:0003777)1.90470924
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90202157
138Rough bone trabeculation (HP:0100670)1.89585455
139Furrowed tongue (HP:0000221)1.88956014
140Hyperbilirubinemia (HP:0002904)1.88946307
141Megaloblastic anemia (HP:0001889)1.88644615
142Abnormality of renal excretion (HP:0011036)1.88528707
143Sparse eyelashes (HP:0000653)1.88205431
144Abnormality of magnesium homeostasis (HP:0004921)1.86859582
145IgM deficiency (HP:0002850)1.86673521
146Delayed CNS myelination (HP:0002188)1.86228102
147Spastic paraparesis (HP:0002313)1.83634495
148Abnormality of methionine metabolism (HP:0010901)1.82497975
149Hypoplasia of the uterus (HP:0000013)1.81504837
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.80030373
151Congenital stationary night blindness (HP:0007642)1.75214168
152Abnormality of the renal cortex (HP:0011035)1.73684330
153Septate vagina (HP:0001153)1.73659549
154Hypomagnesemia (HP:0002917)1.71226843
155Hypokinesia (HP:0002375)1.71140804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.39053982
2NME24.11594850
3STK163.60381927
4WEE13.55524659
5EIF2AK13.22171262
6BUB13.02192845
7MAPK152.76939345
8PIM22.72836158
9VRK22.71968260
10EIF2AK32.36517040
11NME12.33425663
12MST1R2.14432083
13VRK12.08735304
14MYLK2.02388459
15TRIB32.00914848
16GRK11.98674935
17FLT31.93500670
18FRK1.73375164
19PDK41.72088801
20PDK31.72088801
21KDR1.69089867
22WNK41.63511026
23MAP3K121.61677654
24NUAK11.61022280
25RPS6KB21.50238998
26MAP3K111.49829027
27MUSK1.47678175
28SRPK11.45024885
29MAP4K11.41781182
30TEC1.41231026
31ACVR1B1.40964863
32TSSK61.39975098
33PDK21.39805407
34TRIM281.37380629
35MAP2K31.37167260
36SIK11.37054593
37BRSK21.36669814
38TESK21.36664272
39MAPKAPK31.34483650
40ERN11.33944811
41PKN21.32355722
42STK391.32100768
43MAP2K71.31705745
44EPHA21.26772149
45MAP4K21.26350647
46ZAK1.22795973
47NEK11.21510123
48TESK11.17284610
49DYRK31.16443501
50MAP2K61.14699279
51LRRK21.13717195
52TGFBR11.12743575
53ZAP701.10256288
54MST41.10132379
55BTK1.06397649
56CDK71.02215177
57CDC71.00253567
58KIT0.99517625
59ARAF0.99264848
60BMPR1B0.97960815
61PLK40.96689816
62PTK60.95313149
63TLK10.95044816
64PHKG20.94738578
65PHKG10.94738578
66PIK3CA0.91685425
67ILK0.89818706
68PRKD30.85297388
69OBSCN0.84314164
70CDK80.81761261
71ABL20.80653286
72NEK60.80140994
73NEK20.78719220
74AURKB0.78453955
75EIF2AK20.77707504
76CDK40.76502014
77SMG10.75588320
78MAP2K20.75525915
79AURKA0.75454726
80CAMK2D0.74101528
81IRAK30.72005224
82PLK10.71993176
83OXSR10.69927801
84INSRR0.69668450
85MAPK40.69263014
86CSNK2A20.69249636
87MAP3K30.69175501
88TAOK20.68513250
89PIM10.67976983
90CSNK2A10.67482481
91PAK40.67135819
92BRAF0.66299151
93ADRBK10.66156927
94PINK10.64919910
95ATR0.62522521
96CCNB10.61860312
97SIK30.61844691
98CAMK2G0.61688739
99GRK60.61008846
100WNK30.60532668
101CHUK0.60047413
102TNK20.59410681
103FER0.58893359
104MAP3K80.58638444
105TTK0.57525460
106TAOK10.56206756
107TIE10.55247195
108AKT20.54076857
109RPS6KA40.53768885
110TBK10.53675095
111RAF10.53384103
112PRKD20.53093152
113MAP2K10.51930779
114DAPK10.51632394
115BRSK10.51458424
116CDK190.51128291
117TYK20.50558678
118SYK0.50509270
119LMTK20.50248295
120CSNK1A10.50159252
121MATK0.48532627
122PRKCI0.48014848
123STK38L0.47736271
124RPS6KA50.47480756
125MAPKAPK20.47188882
126MET0.46216048
127DYRK20.45316264
128IRAK40.44268394
129SCYL20.43598611
130PRKG20.43235091
131PAK30.43151981
132TAOK30.42687824
133IKBKB0.42685436
134NLK0.42669030
135LIMK10.42551764
136STK240.40492152
137RPS6KA60.39525397
138DAPK30.38983964
139MAP3K60.37396857
140MAPK130.37378305
141PAK10.36916814
142CSNK1G30.36535693
143MKNK10.36227463
144LYN0.34223765
145ADRBK20.33818695
146PRKCE0.33527780
147RPS6KA20.33403924
148TXK0.32996582
149PBK0.32377146
150PRKCZ0.31877079
151MAPKAPK50.26777998
152PRKCD0.26549332

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.81914052
2Proteasome_Homo sapiens_hsa030502.95449176
3DNA replication_Homo sapiens_hsa030302.87856262
4Oxidative phosphorylation_Homo sapiens_hsa001902.63364568
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50818117
6Parkinsons disease_Homo sapiens_hsa050122.49183471
7RNA polymerase_Homo sapiens_hsa030202.34866058
8Mismatch repair_Homo sapiens_hsa034302.18272787
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16084662
10Pyrimidine metabolism_Homo sapiens_hsa002402.13447274
11Caffeine metabolism_Homo sapiens_hsa002322.08684739
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06705380
13Propanoate metabolism_Homo sapiens_hsa006402.00287405
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97925087
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85722495
16Folate biosynthesis_Homo sapiens_hsa007901.84937461
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.77796588
18Huntingtons disease_Homo sapiens_hsa050161.76519944
19Fatty acid degradation_Homo sapiens_hsa000711.74413228
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72785754
21Carbon metabolism_Homo sapiens_hsa012001.72173230
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.71716693
23Base excision repair_Homo sapiens_hsa034101.71574541
24Sulfur relay system_Homo sapiens_hsa041221.68036928
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66883737
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64456616
27Pyruvate metabolism_Homo sapiens_hsa006201.56982623
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54697496
29Alzheimers disease_Homo sapiens_hsa050101.52624944
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51041328
31Nitrogen metabolism_Homo sapiens_hsa009101.49259533
32Pentose phosphate pathway_Homo sapiens_hsa000301.47677610
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47276717
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.44502164
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42014364
36Nucleotide excision repair_Homo sapiens_hsa034201.41922341
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40561065
38Biosynthesis of amino acids_Homo sapiens_hsa012301.39792247
39One carbon pool by folate_Homo sapiens_hsa006701.38837997
40Homologous recombination_Homo sapiens_hsa034401.38512100
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.37860243
42Peroxisome_Homo sapiens_hsa041461.37720116
43Spliceosome_Homo sapiens_hsa030401.35198662
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34830721
45Glutathione metabolism_Homo sapiens_hsa004801.33518145
46Protein export_Homo sapiens_hsa030601.33124231
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31192469
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30761578
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29809746
50Collecting duct acid secretion_Homo sapiens_hsa049661.23007202
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22511982
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21654053
53Fatty acid elongation_Homo sapiens_hsa000621.21335734
54Selenocompound metabolism_Homo sapiens_hsa004501.19575020
55beta-Alanine metabolism_Homo sapiens_hsa004101.18867753
56RNA transport_Homo sapiens_hsa030131.13178884
57Fatty acid metabolism_Homo sapiens_hsa012121.10874246
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10482791
59Fructose and mannose metabolism_Homo sapiens_hsa000511.08629170
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07650421
61Tryptophan metabolism_Homo sapiens_hsa003801.06846359
62Purine metabolism_Homo sapiens_hsa002301.06218782
63Galactose metabolism_Homo sapiens_hsa000521.05215164
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02690074
65Butanoate metabolism_Homo sapiens_hsa006501.02378162
66Chemical carcinogenesis_Homo sapiens_hsa052041.00282796
67Sulfur metabolism_Homo sapiens_hsa009200.98677992
68Mineral absorption_Homo sapiens_hsa049780.97444247
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95558040
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95229139
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94996753
72Phototransduction_Homo sapiens_hsa047440.94711091
73Metabolic pathways_Homo sapiens_hsa011000.93936014
74Steroid biosynthesis_Homo sapiens_hsa001000.90571134
75Histidine metabolism_Homo sapiens_hsa003400.88132247
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84992238
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83913425
78Vitamin B6 metabolism_Homo sapiens_hsa007500.82113884
79Arginine and proline metabolism_Homo sapiens_hsa003300.79623331
80Phenylalanine metabolism_Homo sapiens_hsa003600.75919521
81RNA degradation_Homo sapiens_hsa030180.75320369
82Cardiac muscle contraction_Homo sapiens_hsa042600.74617248
83Tight junction_Homo sapiens_hsa045300.74286541
84PPAR signaling pathway_Homo sapiens_hsa033200.71620509
85Sphingolipid metabolism_Homo sapiens_hsa006000.71265242
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70263812
87Basal transcription factors_Homo sapiens_hsa030220.67169165
88Fat digestion and absorption_Homo sapiens_hsa049750.66823654
89Starch and sucrose metabolism_Homo sapiens_hsa005000.65229750
90Arginine biosynthesis_Homo sapiens_hsa002200.64770501
91Tyrosine metabolism_Homo sapiens_hsa003500.63918757
92Vibrio cholerae infection_Homo sapiens_hsa051100.62836287
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60582543
94Ether lipid metabolism_Homo sapiens_hsa005650.57155345
95N-Glycan biosynthesis_Homo sapiens_hsa005100.56135811
96Non-homologous end-joining_Homo sapiens_hsa034500.53693359
97Retinol metabolism_Homo sapiens_hsa008300.51105258
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50198437
99Vitamin digestion and absorption_Homo sapiens_hsa049770.44363820
100Arachidonic acid metabolism_Homo sapiens_hsa005900.42807243
101Cell cycle_Homo sapiens_hsa041100.42767837
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.42112197
103Fanconi anemia pathway_Homo sapiens_hsa034600.40519958
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40205614
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39703157
106Taste transduction_Homo sapiens_hsa047420.37588112
107Olfactory transduction_Homo sapiens_hsa047400.34637220
108Ovarian steroidogenesis_Homo sapiens_hsa049130.33533702
109Glycerolipid metabolism_Homo sapiens_hsa005610.32273434
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31888107
111Complement and coagulation cascades_Homo sapiens_hsa046100.30770480
112Other glycan degradation_Homo sapiens_hsa005110.27433122
113Linoleic acid metabolism_Homo sapiens_hsa005910.26834571
114Regulation of autophagy_Homo sapiens_hsa041400.26780486
115Epstein-Barr virus infection_Homo sapiens_hsa051690.24878424
116Thyroid cancer_Homo sapiens_hsa052160.23490173
117Renin-angiotensin system_Homo sapiens_hsa046140.22329544
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19955013
119ABC transporters_Homo sapiens_hsa020100.17827824

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