ABCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14531250
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.14531250
3antigen processing and presentation of endogenous antigen (GO:0019883)4.89613207
4positive regulation of gamma-delta T cell activation (GO:0046645)4.77324955
5positive regulation of B cell differentiation (GO:0045579)4.29747989
6positive regulation by symbiont of host defense response (GO:0052509)4.21716423
7modulation by symbiont of host defense response (GO:0052031)4.21716423
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21716423
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21716423
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.21716423
11modulation by symbiont of host immune response (GO:0052553)4.21716423
12glycosphingolipid catabolic process (GO:0046479)4.21460561
13regulation of interferon-beta biosynthetic process (GO:0045357)4.16218925
14regulation of B cell receptor signaling pathway (GO:0050855)3.99725791
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80834287
16glycolipid catabolic process (GO:0019377)3.79472453
17regulation of gamma-delta T cell differentiation (GO:0045586)3.77421363
18immunoglobulin mediated immune response (GO:0016064)3.70678238
19regulation of B cell differentiation (GO:0045577)3.58171838
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57049293
21regulation of gamma-delta T cell activation (GO:0046643)3.55476480
22B cell receptor signaling pathway (GO:0050853)3.51366821
23negative regulation of phagocytosis (GO:0050765)3.48475243
24oligosaccharide catabolic process (GO:0009313)3.43880329
25positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.40760605
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.38963486
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33989656
28cellular response to thyroid hormone stimulus (GO:0097067)3.32527318
29regulation of vitamin D biosynthetic process (GO:0060556)3.30505292
30macrophage activation involved in immune response (GO:0002281)3.29274877
31NIK/NF-kappaB signaling (GO:0038061)3.25619170
32positive regulation of interferon-alpha production (GO:0032727)3.20601399
33ceramide catabolic process (GO:0046514)3.20270917
34neutrophil activation involved in immune response (GO:0002283)3.17612786
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10785549
36low-density lipoprotein particle clearance (GO:0034383)3.10452610
37positive regulation of Cdc42 GTPase activity (GO:0043089)3.09437411
38response to thyroid hormone (GO:0097066)3.09014782
39respiratory burst (GO:0045730)3.08131382
40protein localization to endosome (GO:0036010)3.07429965
41regulation of interferon-alpha production (GO:0032647)3.01565617
42amino sugar catabolic process (GO:0046348)2.99428084
43barbed-end actin filament capping (GO:0051016)2.98122108
44Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97028871
45mannose metabolic process (GO:0006013)2.96664016
46detection of molecule of bacterial origin (GO:0032490)2.96596573
47myeloid dendritic cell differentiation (GO:0043011)2.92727367
48cellular extravasation (GO:0045123)2.92034487
49pinocytosis (GO:0006907)2.89829449
50regulation of vitamin metabolic process (GO:0030656)2.89236238
51regulation of interleukin-12 biosynthetic process (GO:0045075)2.89221936
52negative regulation of granulocyte differentiation (GO:0030853)2.88690266
53adhesion of symbiont to host (GO:0044406)2.87804192
54negative regulation of cytokine production involved in immune response (GO:0002719)2.87434920
55regulation of membrane protein ectodomain proteolysis (GO:0051043)2.86169091
56B cell mediated immunity (GO:0019724)2.83097290
57* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82844201
58regulation of T-helper 2 cell differentiation (GO:0045628)2.81912671
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78509139
60response to host immune response (GO:0052572)2.78509139
61membrane lipid catabolic process (GO:0046466)2.78150829
62regulation of cholesterol storage (GO:0010885)2.77739853
63antigen processing and presentation via MHC class Ib (GO:0002475)2.76901192
64positive regulation of chemokine biosynthetic process (GO:0045080)2.76688287
65sphingolipid catabolic process (GO:0030149)2.75961350
66phospholipid efflux (GO:0033700)2.75116203
67response to peptidoglycan (GO:0032494)2.75044536
68regulation of leukocyte degranulation (GO:0043300)2.74647872
69regulation of cytokine secretion involved in immune response (GO:0002739)2.74590594
70cellular response to zinc ion (GO:0071294)2.74466258
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74426256
72germinal center formation (GO:0002467)2.74325667
73regulation of mast cell degranulation (GO:0043304)2.73384490
74detection of other organism (GO:0098543)2.73178494
75adhesion of symbiont to host cell (GO:0044650)2.72440612
76virion attachment to host cell (GO:0019062)2.72440612
77response to type I interferon (GO:0034340)2.70420984
78negative regulation of interleukin-12 production (GO:0032695)2.70127659
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68528063
80negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68157687
81response to laminar fluid shear stress (GO:0034616)2.67094960
82N-acetylneuraminate metabolic process (GO:0006054)2.66712407
83defense response to protozoan (GO:0042832)2.66342550
84cellular response to type I interferon (GO:0071357)2.65697345
85type I interferon signaling pathway (GO:0060337)2.65697345
86regulation of early endosome to late endosome transport (GO:2000641)2.65253162
87detection of external biotic stimulus (GO:0098581)2.65075286
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64526158
89regulation of podosome assembly (GO:0071801)2.63986807
90positive regulation of antigen processing and presentation (GO:0002579)2.63333997
91regulation of triglyceride catabolic process (GO:0010896)2.62888016
92response to fungus (GO:0009620)2.62037928
93positive regulation of lipoprotein lipase activity (GO:0051006)2.61831269
94positive regulation of triglyceride lipase activity (GO:0061365)2.61831269
95response to host (GO:0075136)2.60396261
96response to host defenses (GO:0052200)2.60396261
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60396261
98myeloid cell activation involved in immune response (GO:0002275)2.60283613
99regulation of superoxide anion generation (GO:0032928)2.60124841
100response to muramyl dipeptide (GO:0032495)2.59514924
101negative regulation of erythrocyte differentiation (GO:0045647)2.59063164
102amyloid precursor protein catabolic process (GO:0042987)2.58484308
103modulation by symbiont of host cellular process (GO:0044068)2.58175285
104detection of bacterium (GO:0016045)2.57447402
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56949304
106T-helper 1 type immune response (GO:0042088)2.56609298
107regulation of chemokine biosynthetic process (GO:0045073)2.55394110
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53930227
109regulation of mononuclear cell migration (GO:0071675)2.53006727
110regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52616836
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52467989
112leukocyte aggregation (GO:0070486)2.49763507
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49101799
114glucose 6-phosphate metabolic process (GO:0051156)2.48745939
115disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.48486608
116killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.48486608
117defense response to fungus (GO:0050832)2.48296247
118neutrophil activation (GO:0042119)2.48163023
119positive regulation of interferon-beta production (GO:0032728)2.46913682
120production of molecular mediator involved in inflammatory response (GO:0002532)2.45955444
121regulation of cholesterol esterification (GO:0010872)2.45627607
122response to protozoan (GO:0001562)2.45457141
123mature B cell differentiation involved in immune response (GO:0002313)2.45304731
124positive regulation of leukocyte degranulation (GO:0043302)2.45109329
125negative regulation of cell killing (GO:0031342)2.45021377
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45021377
127mature B cell differentiation (GO:0002335)2.44311028
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43990470
129peptide catabolic process (GO:0043171)2.43844242
130myeloid dendritic cell activation (GO:0001773)2.43739907
131positive regulation of histone deacetylation (GO:0031065)2.43630764
132plasma lipoprotein particle assembly (GO:0034377)2.43417835
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.42697483
134granulocyte activation (GO:0036230)2.42339112
135neutrophil mediated immunity (GO:0002446)2.42271493
136positive regulation of cellular amide metabolic process (GO:0034250)2.42117293
137angiotensin maturation (GO:0002003)2.41616821
138positive thymic T cell selection (GO:0045059)2.41325063
139positive regulation of type 2 immune response (GO:0002830)2.40743125
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.39678685
141regulation of mast cell activation involved in immune response (GO:0033006)2.39149116
142interferon-gamma-mediated signaling pathway (GO:0060333)2.39030427
143tolerance induction (GO:0002507)2.38974969
144protein-lipid complex assembly (GO:0065005)2.38646638
145regulation of T-helper 1 cell differentiation (GO:0045625)2.38552087
146regulation of B cell apoptotic process (GO:0002902)2.37213794
147intestinal cholesterol absorption (GO:0030299)2.37010625
148regulation of type 2 immune response (GO:0002828)2.36201952
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35317367
150plasma lipoprotein particle clearance (GO:0034381)2.35031386
151protein carboxylation (GO:0018214)2.34871004
152peptidyl-glutamic acid carboxylation (GO:0017187)2.34871004
153phospholipid homeostasis (GO:0055091)2.34119218
154stress fiber assembly (GO:0043149)2.33779439
155megakaryocyte development (GO:0035855)2.33462073
156T cell homeostasis (GO:0043029)2.33167874
157detection of biotic stimulus (GO:0009595)2.32952944
158regulation of phagocytosis (GO:0050764)2.32710627
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.32566185
160COPI coating of Golgi vesicle (GO:0048205)2.32274532
161Golgi transport vesicle coating (GO:0048200)2.32274532
162positive regulation of triglyceride metabolic process (GO:0090208)2.31820989
163regulation of extracellular matrix disassembly (GO:0010715)2.31568308
164positive regulation of cholesterol efflux (GO:0010875)2.30961594
165macrophage activation (GO:0042116)2.30610361
166complement activation, alternative pathway (GO:0006957)2.30029630
167urea metabolic process (GO:0019627)2.29274133
168urea cycle (GO:0000050)2.29274133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.57461744
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.53115785
3* IRF8_21731497_ChIP-ChIP_J774_Mouse3.48183460
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.35429296
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17448575
6SCL_19346495_ChIP-Seq_HPC-7_Human2.94999760
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88941390
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86533558
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.83676579
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82605903
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73716499
12VDR_21846776_ChIP-Seq_THP-1_Human2.67639749
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66943545
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.62815851
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58495186
16MYC_22102868_ChIP-Seq_BL_Human2.56046115
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.51362385
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50737977
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46879476
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46833156
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46708301
22* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42125706
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40755304
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.29212583
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23821200
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19736765
27LXR_22158963_ChIP-Seq_LIVER_Mouse2.09627284
28RACK7_27058665_Chip-Seq_MCF-7_Human2.07970067
29MAF_26560356_Chip-Seq_TH1_Human2.07187119
30VDR_24763502_ChIP-Seq_THP-1_Human2.05192908
31E2F7_22180533_ChIP-Seq_HELA_Human2.05105085
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02189221
33ZNF263_19887448_ChIP-Seq_K562_Human2.02132845
34* SPI1_23547873_ChIP-Seq_NB4_Human2.00226801
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96109045
36GATA1_22025678_ChIP-Seq_K562_Human1.92767537
37MYB_26560356_Chip-Seq_TH2_Human1.90963847
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88977272
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.88561845
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87523603
41TCF7_22412390_ChIP-Seq_EML_Mouse1.84954590
42SPI1_23127762_ChIP-Seq_K562_Human1.82088413
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.81895356
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81135847
45RUNX_20019798_ChIP-Seq_JUKART_Human1.80881008
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80374752
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75367764
48MYB_26560356_Chip-Seq_TH1_Human1.75315244
49UTX_26944678_Chip-Seq_JUKART_Human1.74411707
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72643691
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71563331
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70770438
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70181439
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69698446
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69428488
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66911634
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64136253
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62978619
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59896300
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.56232805
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51156576
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50169788
63KDM2B_26808549_Chip-Seq_K562_Human1.48921436
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46698490
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46694750
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42215590
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41831781
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.40275542
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37994651
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37849187
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35319830
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35277828
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35141675
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34964713
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33512438
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33284443
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32813741
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31144787
79PU_27001747_Chip-Seq_BMDM_Mouse1.31107254
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30397549
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29304439
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29004640
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27491315
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27279597
85CLOCK_20551151_ChIP-Seq_293T_Human1.26352179
86P68_20966046_ChIP-Seq_HELA_Human1.26232819
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26084406
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23751775
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22223205
90KDM2B_26808549_Chip-Seq_DND41_Human1.21961571
91BCOR_27268052_Chip-Seq_Bcells_Human1.21421296
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.21249615
93* LXR_22292898_ChIP-Seq_THP-1_Human1.21119216
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20508814
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.19718363
96GATA3_27048872_Chip-Seq_THYMUS_Human1.19268535
97MAF_26560356_Chip-Seq_TH2_Human1.19265311
98* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19084002
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17783065
100GATA1_19941826_ChIP-Seq_K562_Human1.16931228
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16138339
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.15179011
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14263389
104SMC4_20622854_ChIP-Seq_HELA_Human1.13670162
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.13094021
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12265126
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10659508
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09338490
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09199992
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08483906
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08344918
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.08030407
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07877521
114ATF3_27146783_Chip-Seq_COLON_Human1.07714623
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.07396417
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.07172704
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07050695
118EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06594779
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06198086
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05817907
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05031102
122GATA2_19941826_ChIP-Seq_K562_Human1.04586393
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04205030
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03443726
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02913905
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02770538
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01094953
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97450816
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97085487
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95569219
131CIITA_25753668_ChIP-Seq_RAJI_Human0.94165666
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93726338
133GATA3_26560356_Chip-Seq_TH2_Human0.93467178
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93076741
135VDR_24787735_ChIP-Seq_THP-1_Human0.92833408
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90670484
137BCL6_27268052_Chip-Seq_Bcells_Human0.89535442
138* NCOR1_26117541_ChIP-Seq_K562_Human0.88976618
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86566096
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85410582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.40677144
2MP0009840_abnormal_foam_cell3.03134491
3MP0002139_abnormal_hepatobiliary_system2.90388442
4MP0005360_urolithiasis2.82949255
5MP0003436_decreased_susceptibility_to2.75857570
6MP0003191_abnormal_cellular_cholesterol2.75242215
7MP0003303_peritoneal_inflammation2.58395447
8MP0000685_abnormal_immune_system2.49644038
9MP0003705_abnormal_hypodermis_morpholog2.46675815
10MP0001800_abnormal_humoral_immune2.37479249
11MP0001790_abnormal_immune_system2.36125719
12MP0005387_immune_system_phenotype2.36125719
13MP0005058_abnormal_lysosome_morphology2.34064257
14MP0005464_abnormal_platelet_physiology2.32907952
15MP0002419_abnormal_innate_immunity2.30416197
16MP0009785_altered_susceptibility_to2.22913653
17MP0005025_abnormal_response_to2.19884038
18MP0005365_abnormal_bile_salt2.19104004
19MP0002452_abnormal_antigen_presenting2.18611601
20MP0005000_abnormal_immune_tolerance2.17414004
21MP0002396_abnormal_hematopoietic_system2.13187489
22MP0005671_abnormal_response_to2.13053731
23MP0002723_abnormal_immune_serum2.04078171
24MP0003300_gastrointestinal_ulcer2.03586219
25MP0002420_abnormal_adaptive_immunity1.93868665
26MP0001819_abnormal_immune_cell1.93069491
27MP0008260_abnormal_autophagy1.91276996
28MP0002148_abnormal_hypersensitivity_rea1.81929279
29MP0005085_abnormal_gallbladder_physiolo1.80271565
30MP0003453_abnormal_keratinocyte_physiol1.77584618
31MP0003724_increased_susceptibility_to1.75334007
32MP0002877_abnormal_melanocyte_morpholog1.74165305
33MP0001853_heart_inflammation1.73959887
34MP0006082_CNS_inflammation1.72619192
35MP0002398_abnormal_bone_marrow1.72071146
36MP0008875_abnormal_xenobiotic_pharmacok1.66905329
37MP0002166_altered_tumor_susceptibility1.66636649
38MP0000689_abnormal_spleen_morphology1.64997534
39* MP0000716_abnormal_immune_system1.64734929
40MP0010329_abnormal_lipoprotein_level1.63940492
41MP0008469_abnormal_protein_level1.59126905
42MP0002405_respiratory_system_inflammati1.57440716
43* MP0001845_abnormal_inflammatory_respons1.57125924
44MP0005076_abnormal_cell_differentiation1.56715392
45MP0003172_abnormal_lysosome_physiology1.53089659
46MP0001849_ear_inflammation1.50386080
47MP0004947_skin_inflammation1.49934951
48MP0010155_abnormal_intestine_physiology1.48321835
49MP0004510_myositis1.47748995
50MP0009333_abnormal_splenocyte_physiolog1.46365533
51MP0009278_abnormal_bone_marrow1.45784149
52MP0003252_abnormal_bile_duct1.45398379
53MP0004858_abnormal_nervous_system1.45111776
54MP0005257_abnormal_intraocular_pressure1.44942656
55MP0003656_abnormal_erythrocyte_physiolo1.44667070
56MP0002722_abnormal_immune_system1.43020808
57* MP0002429_abnormal_blood_cell1.42739385
58MP0008438_abnormal_cutaneous_collagen1.41689185
59MP0000609_abnormal_liver_physiology1.41529070
60MP0005397_hematopoietic_system_phenotyp1.40526034
61MP0001545_abnormal_hematopoietic_system1.40526034
62MP0004808_abnormal_hematopoietic_stem1.38754119
63MP0001666_abnormal_nutrient_absorption1.38000593
64MP0003183_abnormal_peptide_metabolism1.37955923
65MP0001533_abnormal_skeleton_physiology1.36568022
66MP0000465_gastrointestinal_hemorrhage1.35639649
67MP0000343_altered_response_to1.34136696
68MP0001873_stomach_inflammation1.33949217
69MP0003763_abnormal_thymus_physiology1.33709604
70MP0003091_abnormal_cell_migration1.22902502
71MP0009764_decreased_sensitivity_to1.19078051
72MP0005319_abnormal_enzyme/_coenzyme1.18944799
73MP0008004_abnormal_stomach_pH1.13158812
74MP0003866_abnormal_defecation1.12919015
75MP0004185_abnormal_adipocyte_glucose1.12771965
76MP0002254_reproductive_system_inflammat1.10405417
77MP0002933_joint_inflammation1.10057758
78MP0002006_tumorigenesis1.08449765
79MP0009763_increased_sensitivity_to1.07482932
80MP0003075_altered_response_to1.05696575
81MP0005666_abnormal_adipose_tissue1.03031062
82MP0000598_abnormal_liver_morphology1.00631587
83* MP0002118_abnormal_lipid_homeostasis0.98414705
84MP0004130_abnormal_muscle_cell0.97844272
85MP0003329_amyloid_beta_deposits0.97158403
86MP0005083_abnormal_biliary_tract0.97041215
87MP0005174_abnormal_tail_pigmentation0.96983097
88MP0005451_abnormal_body_composition0.96548551
89MP0010234_abnormal_vibrissa_follicle0.95475050
90MP0005584_abnormal_enzyme/coenzyme_acti0.95352912
91MP0000703_abnormal_thymus_morphology0.93729607
92MP0005390_skeleton_phenotype0.93622855
93MP0002138_abnormal_hepatobiliary_system0.93548055
94MP0000604_amyloidosis0.92831434
95MP0004233_abnormal_muscle_weight0.91093452
96MP0000249_abnormal_blood_vessel0.90984625
97MP0003806_abnormal_nucleotide_metabolis0.90681590
98MP0005164_abnormal_response_to0.89270043
99MP0004381_abnormal_hair_follicle0.89108377
100MP0009643_abnormal_urine_homeostasis0.88313842
101MP0005409_darkened_coat_color0.88119245
102MP0006054_spinal_hemorrhage0.87672034
103MP0002332_abnormal_exercise_endurance0.87416739
104MP0003828_pulmonary_edema0.86759842
105MP0005167_abnormal_blood-brain_barrier0.86558314
106MP0000490_abnormal_crypts_of0.86455430
107MP0003566_abnormal_cell_adhesion0.86426813
108MP0005310_abnormal_salivary_gland0.84432767
109MP0003448_altered_tumor_morphology0.82174657
110MP0005166_decreased_susceptibility_to0.81965219
111MP0005375_adipose_tissue_phenotype0.81956666
112MP0005332_abnormal_amino_acid0.79916439
113MP0000747_muscle_weakness0.78074061
114MP0003795_abnormal_bone_structure0.77927267
115MP0000858_altered_metastatic_potential0.76770063
116MP0005670_abnormal_white_adipose0.73432423
117MP0002998_abnormal_bone_remodeling0.73131722
118MP0002971_abnormal_brown_adipose0.71944131
119MP0005165_increased_susceptibility_to0.70762910
120MP0000371_diluted_coat_color0.70462647
121MP0009642_abnormal_blood_homeostasis0.69700204
122MP0002136_abnormal_kidney_physiology0.69416801
123MP0004883_abnormal_blood_vessel0.69187418
124MP0004264_abnormal_extraembryonic_tissu0.68994597
125MP0005023_abnormal_wound_healing0.68684512
126MP0001851_eye_inflammation0.68666263
127MP0001663_abnormal_digestive_system0.68664949
128MP0003690_abnormal_glial_cell0.68121302
129MP0003186_abnormal_redox_activity0.66443709
130MP0003279_aneurysm0.64697337

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.65077068
2Recurrent bacterial skin infections (HP:0005406)4.36067227
3Eczematoid dermatitis (HP:0000976)4.11399702
4Systemic lupus erythematosus (HP:0002725)3.86032369
5Recurrent gram-negative bacterial infections (HP:0005420)3.77203422
6Recurrent viral infections (HP:0004429)3.57114326
7Cellulitis (HP:0100658)3.38577484
8Elevated erythrocyte sedimentation rate (HP:0003565)3.38086166
9Myositis (HP:0100614)3.32667776
10Vacuolated lymphocytes (HP:0001922)3.30452116
11Chronic otitis media (HP:0000389)3.27595486
12Recurrent fungal infections (HP:0002841)3.24414764
13Increased cerebral lipofuscin (HP:0011813)3.20324722
14Colitis (HP:0002583)3.13388677
15Autoimmune thrombocytopenia (HP:0001973)3.11291024
16Nuclear cataract (HP:0100018)3.11256567
17Recurrent skin infections (HP:0001581)3.08121365
18Spontaneous hematomas (HP:0007420)3.05310969
19Joint hemorrhage (HP:0005261)3.05217561
20Agammaglobulinemia (HP:0004432)3.02661794
21* Loss of speech (HP:0002371)3.02661402
22Abnormality of macrophages (HP:0004311)2.98675209
23IgM deficiency (HP:0002850)2.98202964
24Meningitis (HP:0001287)2.93870354
25Inflammation of the large intestine (HP:0002037)2.92537565
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.91615948
27Vertebral compression fractures (HP:0002953)2.90275542
28Gastrointestinal inflammation (HP:0004386)2.87762070
29Dysostosis multiplex (HP:0000943)2.85652063
30Abnormal platelet function (HP:0011869)2.83563655
31Impaired platelet aggregation (HP:0003540)2.83563655
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.83516468
33Thrombocytosis (HP:0001894)2.77937131
34Mucopolysacchariduria (HP:0008155)2.77076181
35Urinary glycosaminoglycan excretion (HP:0003541)2.77076181
36Glomerulonephritis (HP:0000099)2.74750691
37Interstitial pulmonary disease (HP:0006530)2.72095357
38Deep venous thrombosis (HP:0002625)2.69044195
39Complement deficiency (HP:0004431)2.66801896
40Xanthomatosis (HP:0000991)2.60199375
41Purpura (HP:0000979)2.59374489
42Epistaxis (HP:0000421)2.58299567
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57454371
44Abnormality of polysaccharide metabolism (HP:0011012)2.57454371
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57454371
46Thin bony cortex (HP:0002753)2.57274985
47Panhypogammaglobulinemia (HP:0003139)2.57023043
48Amyloidosis (HP:0011034)2.53647045
49Mediastinal lymphadenopathy (HP:0100721)2.52930795
50Neurofibrillary tangles (HP:0002185)2.52676203
51Periodontitis (HP:0000704)2.52604884
52Pustule (HP:0200039)2.52572809
53Disinhibition (HP:0000734)2.50438203
54Gingival bleeding (HP:0000225)2.50227335
55Orchitis (HP:0100796)2.50192238
56Vasculitis (HP:0002633)2.49080015
57Cerebral aneurysm (HP:0004944)2.49012816
58Prolonged bleeding time (HP:0003010)2.48794365
59Gingivitis (HP:0000230)2.48061249
60J-shaped sella turcica (HP:0002680)2.42630987
61Abnormality of T cell physiology (HP:0011840)2.42476573
62Recurrent bronchitis (HP:0002837)2.41039194
63Myocardial infarction (HP:0001658)2.40612198
64Abnormality of the common coagulation pathway (HP:0010990)2.39700096
65Abnormality of the nasal mucosa (HP:0000433)2.39060235
66Petechiae (HP:0000967)2.38335477
67Hemorrhage of the eye (HP:0011885)2.33748649
68Asymmetric septal hypertrophy (HP:0001670)2.33521924
69Chronic obstructive pulmonary disease (HP:0006510)2.33028565
70Obstructive lung disease (HP:0006536)2.33028565
71Abnormality of complement system (HP:0005339)2.31914460
72Retrobulbar optic neuritis (HP:0100654)2.30639789
73Optic neuritis (HP:0100653)2.30639789
74Nasal polyposis (HP:0100582)2.30407261
75Pathologic fracture (HP:0002756)2.30281903
76Thoracic kyphosis (HP:0002942)2.27321960
77Osteomyelitis (HP:0002754)2.26040883
78Upper motor neuron abnormality (HP:0002127)2.24706897
79Distal lower limb muscle weakness (HP:0009053)2.23911168
80Arterial thrombosis (HP:0004420)2.23764081
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22420175
82Achilles tendon contracture (HP:0001771)2.22251488
83Chest pain (HP:0100749)2.20718180
84Neuronal loss in central nervous system (HP:0002529)2.18800592
85Abnormality of T cells (HP:0002843)2.18602472
86Cerebral inclusion bodies (HP:0100314)2.18419651
87Bone pain (HP:0002653)2.17309571
88Recurrent cutaneous fungal infections (HP:0011370)2.17216582
89Chronic mucocutaneous candidiasis (HP:0002728)2.17216582
90Malnutrition (HP:0004395)2.16136094
91Hypercholesterolemia (HP:0003124)2.15026365
92Gastrointestinal infarctions (HP:0005244)2.15026160
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14574407
94Increased connective tissue (HP:0009025)2.14168331
95Hypobetalipoproteinemia (HP:0003563)2.12578633
96Progressive neurologic deterioration (HP:0002344)2.11270060
97Prolonged partial thromboplastin time (HP:0003645)2.09681271
98Granulocytopenia (HP:0001913)2.09421792
99Hyperlipoproteinemia (HP:0010980)2.08661401
100Verrucae (HP:0200043)2.08547821
101Papilloma (HP:0012740)2.08547821
102Prolonged neonatal jaundice (HP:0006579)2.08472224
103Encephalitis (HP:0002383)2.08373157
104Hepatosplenomegaly (HP:0001433)2.08246135
105Mitral stenosis (HP:0001718)2.06621383
106Leukocytosis (HP:0001974)2.05762352
107Abnormality of the Achilles tendon (HP:0005109)2.05499612
108Abnormality of glycolipid metabolism (HP:0010969)2.05250026
109Abnormality of liposaccharide metabolism (HP:0010968)2.05250026
110Abnormality of glycosphingolipid metabolism (HP:0004343)2.05250026
111Cervical subluxation (HP:0003308)2.05024700
112Hematochezia (HP:0002573)2.04667704
113Axonal loss (HP:0003447)2.04635230
114Urticaria (HP:0001025)2.04622747
115Abnormal platelet volume (HP:0011876)2.03744361
116Distal lower limb amyotrophy (HP:0008944)2.03258449
117Hypoglycemic coma (HP:0001325)2.03218980
118Gastrointestinal stroma tumor (HP:0100723)2.02803927
119Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02324181
120Menorrhagia (HP:0000132)2.01418639
121Eosinophilia (HP:0001880)2.01341904
122Thyroiditis (HP:0100646)2.01083212
123Premature rupture of membranes (HP:0001788)1.99853291
124Abnormality of the intrinsic pathway (HP:0010989)1.99517391
125Abnormality of iron homeostasis (HP:0011031)1.98826937
126Pulmonary embolism (HP:0002204)1.97046174
127Chronic diarrhea (HP:0002028)1.95624372
128Increased IgE level (HP:0003212)1.95252874
129Apathy (HP:0000741)1.94913511
130Lymphopenia (HP:0001888)1.94557048
131Increased serum ferritin (HP:0003281)1.93152161
132Diminished motivation (HP:0000745)1.91363886
133Broad face (HP:0000283)1.89675028
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88846376
135Abnormality of the thoracic spine (HP:0100711)1.88202454
136Protrusio acetabuli (HP:0003179)1.85878075
137Mutism (HP:0002300)1.85332146
138Stomatitis (HP:0010280)1.83631504
139Hypertriglyceridemia (HP:0002155)1.83543925
140Distal upper limb amyotrophy (HP:0007149)1.80715481
141Upper limb amyotrophy (HP:0009129)1.80715481
142Esophageal varix (HP:0002040)1.78020755
143Joint stiffness (HP:0001387)1.76325671
144Cardiomegaly (HP:0001640)1.74074922
145Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73359473
146Spondylolisthesis (HP:0003302)1.73291350
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.72470705
148Hyperacusis (HP:0010780)1.72009669
149Hypophosphatemia (HP:0002148)1.71187534
150Elevated alkaline phosphatase (HP:0003155)1.66875929
151Pulmonary infiltrates (HP:0002113)1.66319829
152Peripheral demyelination (HP:0011096)1.66253335
153Flat acetabular roof (HP:0003180)1.64727295
154Hyperparathyroidism (HP:0000843)1.63898007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.13430485
2EEF2K3.68528653
3ERN13.66409580
4NME22.86945059
5PRPF4B2.60921275
6KIT2.37406760
7MAP3K102.35711666
8TYK22.30667943
9TAOK22.21668524
10CSF1R2.21126576
11TRIB32.20678644
12PKN22.17323340
13ICK2.16337952
14BLK2.16229637
15TGFBR22.14872015
16IRAK42.14007960
17MAP2K32.13283282
18TBK12.10024103
19BTK2.00873016
20ZAP701.91317621
21IRAK31.89014349
22TAOK31.87352381
23MAP3K141.73977902
24DDR21.73408535
25EPHB11.69042721
26TAOK11.68855636
27SMG11.68800010
28FLT31.66698765
29MAPKAPK31.64824687
30STK101.63192897
31JAK31.58748608
32SYK1.56200787
33GRK61.54912126
34TEC1.53377684
35FGFR41.45453701
36TESK21.44794129
37TRPM71.44759502
38JAK11.42765096
39SIK11.42631054
40IKBKE1.38902858
41CSK1.37520598
42MAP3K131.36931209
43EPHA21.35364171
44MST1R1.34070980
45CDC42BPA1.33826769
46IKBKB1.32140251
47TTN1.31647258
48FGR1.26721068
49TESK11.25483467
50MAP3K11.24481773
51ITK1.22315075
52IRAK21.19106303
53PTK61.19058348
54TXK1.16841556
55HCK1.15149632
56BCKDK1.12398696
57FES1.12385041
58LRRK21.12093197
59GRK71.09141041
60RPS6KA40.98483389
61PIK3CG0.97351424
62LCK0.96455657
63RIPK40.95971868
64MATK0.95970132
65RIPK10.95143011
66PRKD20.94852063
67MOS0.94310228
68LYN0.93207491
69TNK20.92004539
70PDGFRA0.91300121
71PDPK10.90979080
72CLK10.89977256
73JAK20.86253122
74MAPK110.85125720
75CAMK1D0.82004348
76CHUK0.80301875
77KDR0.80046543
78PIM10.79444693
79RPS6KB20.79142118
80ABL20.75336833
81TGFBR10.74791877
82MARK20.73267014
83LMTK20.72711482
84MAP3K70.70517059
85STK40.69964173
86PRKG20.67271929
87PAK40.66165068
88MAPK120.66080060
89CDK40.64337512
90BMX0.63275648
91NEK90.61830461
92TIE10.61679618
93MAP3K30.61056806
94PRKAA20.60663384
95MAPK40.59701721
96HIPK20.59306066
97PRKD30.59000849
98MTOR0.58009291
99ARAF0.57525126
100FGFR30.57389784
101MAP3K110.57000770
102IRAK10.56004530
103SIK20.55522661
104RPS6KA60.54955792
105CAMK1G0.51840941
106NLK0.51819478
107KSR20.51472031
108MAP2K20.50386851
109MAP2K60.47260623
110PTK20.46986215
111RPS6KL10.46654291
112RPS6KC10.46654291
113MAPK70.46438002
114SCYL20.46393779
115MAPKAPK20.45691165
116DMPK0.44509653
117TYRO30.43405656
118CDK60.42120935
119MARK30.42023464
120PRKCQ0.39973088
121MAPKAPK50.39415272
122MAP3K60.38479328
123PDK20.38077483
124STK240.37958791
125RPS6KA20.37618005
126PRKCH0.36387077
127PIM20.36009558
128CDK120.34984431
129ABL10.31456670
130EPHA30.31373203
131PDK10.30806702
132PRKCD0.29835231
133MAP3K80.29604054
134EGFR0.29498636
135MYLK0.28888189
136SIK30.28532469
137DYRK1B0.28173066

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.02450711
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60688227
3Leishmaniasis_Homo sapiens_hsa051402.37622608
4B cell receptor signaling pathway_Homo sapiens_hsa046622.29032845
5Caffeine metabolism_Homo sapiens_hsa002322.28652412
6Primary immunodeficiency_Homo sapiens_hsa053402.20166695
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.17938994
8Other glycan degradation_Homo sapiens_hsa005111.97537417
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.96378871
10Complement and coagulation cascades_Homo sapiens_hsa046101.92446580
11Fatty acid degradation_Homo sapiens_hsa000711.88214653
12Osteoclast differentiation_Homo sapiens_hsa043801.83459217
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.79602216
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70545932
15Rheumatoid arthritis_Homo sapiens_hsa053231.60328406
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59152456
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54174782
18Lysosome_Homo sapiens_hsa041421.51605644
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.49939152
20Tryptophan metabolism_Homo sapiens_hsa003801.42525159
21Starch and sucrose metabolism_Homo sapiens_hsa005001.42428450
22PPAR signaling pathway_Homo sapiens_hsa033201.41167065
23Legionellosis_Homo sapiens_hsa051341.40891183
24Measles_Homo sapiens_hsa051621.40259259
25Pertussis_Homo sapiens_hsa051331.39496617
26Allograft rejection_Homo sapiens_hsa053301.38922385
27Prion diseases_Homo sapiens_hsa050201.38083448
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34403637
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32753970
30Antigen processing and presentation_Homo sapiens_hsa046121.32495604
31Hematopoietic cell lineage_Homo sapiens_hsa046401.29398995
32Bladder cancer_Homo sapiens_hsa052191.27029350
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25831829
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22888459
35Tuberculosis_Homo sapiens_hsa051521.20734312
36Phagosome_Homo sapiens_hsa041451.19968422
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19066677
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17830984
39Graft-versus-host disease_Homo sapiens_hsa053321.17519777
40Fatty acid metabolism_Homo sapiens_hsa012121.15868374
41Fat digestion and absorption_Homo sapiens_hsa049751.15745476
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.15466051
43Arginine biosynthesis_Homo sapiens_hsa002201.14321990
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14235777
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12420450
46Nitrogen metabolism_Homo sapiens_hsa009101.11929096
47Asthma_Homo sapiens_hsa053101.10431213
48Toxoplasmosis_Homo sapiens_hsa051451.09213685
49Acute myeloid leukemia_Homo sapiens_hsa052211.09031351
50Galactose metabolism_Homo sapiens_hsa000521.08909079
51Amoebiasis_Homo sapiens_hsa051461.08459687
52Autoimmune thyroid disease_Homo sapiens_hsa053201.08290412
53* ABC transporters_Homo sapiens_hsa020101.04444806
54Selenocompound metabolism_Homo sapiens_hsa004501.04127299
55VEGF signaling pathway_Homo sapiens_hsa043701.02129827
56Influenza A_Homo sapiens_hsa051641.01911808
57Insulin resistance_Homo sapiens_hsa049311.01820353
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.01145815
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00779657
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98884244
61Herpes simplex infection_Homo sapiens_hsa051680.98711592
62Notch signaling pathway_Homo sapiens_hsa043300.98703815
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.97210344
64* Peroxisome_Homo sapiens_hsa041460.97195598
65Histidine metabolism_Homo sapiens_hsa003400.96941360
66Malaria_Homo sapiens_hsa051440.96568361
67Lysine degradation_Homo sapiens_hsa003100.95797462
68Folate biosynthesis_Homo sapiens_hsa007900.95422100
69Renin-angiotensin system_Homo sapiens_hsa046140.94191663
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93953485
71Pentose phosphate pathway_Homo sapiens_hsa000300.93802503
72African trypanosomiasis_Homo sapiens_hsa051430.92801931
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92371663
74Vibrio cholerae infection_Homo sapiens_hsa051100.91794283
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90021735
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89164745
77Shigellosis_Homo sapiens_hsa051310.88560951
78Apoptosis_Homo sapiens_hsa042100.87247987
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83825119
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.81140490
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80976642
82Sphingolipid metabolism_Homo sapiens_hsa006000.79227032
83Vitamin digestion and absorption_Homo sapiens_hsa049770.79090148
84Chemokine signaling pathway_Homo sapiens_hsa040620.78621685
85Platelet activation_Homo sapiens_hsa046110.78515748
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.78211392
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78070641
88Prolactin signaling pathway_Homo sapiens_hsa049170.75740554
89beta-Alanine metabolism_Homo sapiens_hsa004100.74212763
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74124088
91Non-small cell lung cancer_Homo sapiens_hsa052230.73568555
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73380923
93Viral myocarditis_Homo sapiens_hsa054160.72889655
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.71372931
95Chronic myeloid leukemia_Homo sapiens_hsa052200.70982712
96Hepatitis B_Homo sapiens_hsa051610.68484519
97Hepatitis C_Homo sapiens_hsa051600.68095116
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.67018380
99Propanoate metabolism_Homo sapiens_hsa006400.66866152
100T cell receptor signaling pathway_Homo sapiens_hsa046600.66482062
101Insulin signaling pathway_Homo sapiens_hsa049100.65839184
102Type I diabetes mellitus_Homo sapiens_hsa049400.64809784
103TNF signaling pathway_Homo sapiens_hsa046680.64403295
104Carbon metabolism_Homo sapiens_hsa012000.63803905
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.63620218
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.63422402
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61990755
108Fructose and mannose metabolism_Homo sapiens_hsa000510.60397911
109Collecting duct acid secretion_Homo sapiens_hsa049660.60160009
110Chemical carcinogenesis_Homo sapiens_hsa052040.59662119
111Endocytosis_Homo sapiens_hsa041440.59434281
112Renal cell carcinoma_Homo sapiens_hsa052110.57000574
113Salmonella infection_Homo sapiens_hsa051320.55724229
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55032355
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53508794
116mTOR signaling pathway_Homo sapiens_hsa041500.52773947
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52712900
118Pancreatic cancer_Homo sapiens_hsa052120.51805029
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51721817
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49724780
121HIF-1 signaling pathway_Homo sapiens_hsa040660.49039952
122Small cell lung cancer_Homo sapiens_hsa052220.48584028
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.47511500
124Endometrial cancer_Homo sapiens_hsa052130.47402980
125Bile secretion_Homo sapiens_hsa049760.47402882
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47345179
127HTLV-I infection_Homo sapiens_hsa051660.47215736
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47158786
129GnRH signaling pathway_Homo sapiens_hsa049120.47054375
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46891274
131Epstein-Barr virus infection_Homo sapiens_hsa051690.46528667
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45987075
133Glycerolipid metabolism_Homo sapiens_hsa005610.45954683
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45441894
135Fatty acid elongation_Homo sapiens_hsa000620.45207813
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44388484
137Proteoglycans in cancer_Homo sapiens_hsa052050.43013487
138Mineral absorption_Homo sapiens_hsa049780.42740272
139Viral carcinogenesis_Homo sapiens_hsa052030.40530480
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40025645
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39498378

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