ABCC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.23368682
2cardiac myofibril assembly (GO:0055003)7.22162198
3myofibril assembly (GO:0030239)6.65873676
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.43972256
5actin-myosin filament sliding (GO:0033275)6.23713182
6muscle filament sliding (GO:0030049)6.23713182
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.94548268
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.88220259
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.79567571
10negative regulation of potassium ion transmembrane transport (GO:1901380)5.73663244
11regulation of skeletal muscle contraction (GO:0014819)5.58968529
12carnitine shuttle (GO:0006853)5.47771007
13tricarboxylic acid cycle (GO:0006099)5.38895712
14cardiac muscle contraction (GO:0060048)5.37161628
15actin-mediated cell contraction (GO:0070252)5.23457427
16plasma membrane repair (GO:0001778)5.16452659
17regulation of actin filament-based movement (GO:1903115)5.16155833
18regulation of relaxation of muscle (GO:1901077)5.09083737
19fatty acid transmembrane transport (GO:1902001)5.07996021
20cardiac muscle cell development (GO:0055013)5.05365304
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.03618686
22heart trabecula formation (GO:0060347)4.79543432
23sarcoplasmic reticulum calcium ion transport (GO:0070296)4.77912974
24actomyosin structure organization (GO:0031032)4.77787548
25cardiac cell development (GO:0055006)4.75968654
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73706662
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.73313903
28cardiac muscle tissue morphogenesis (GO:0055008)4.67125227
29ventricular cardiac muscle cell action potential (GO:0086005)4.65523854
30regulation of sarcomere organization (GO:0060297)4.62954157
31cardiac muscle hypertrophy (GO:0003300)4.61020689
32regulation of cell communication by electrical coupling (GO:0010649)4.59317341
33lymph vessel development (GO:0001945)4.58373346
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.58143034
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.48723651
36striated muscle contraction (GO:0006941)4.47763846
37behavioral response to nicotine (GO:0035095)4.47470227
38striated muscle hypertrophy (GO:0014897)4.42972956
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.38886324
40vascular endothelial growth factor signaling pathway (GO:0038084)4.36345889
41adult heart development (GO:0007512)4.27688131
42muscle tissue morphogenesis (GO:0060415)4.27385173
43regulation of acyl-CoA biosynthetic process (GO:0050812)4.26610105
44indole-containing compound catabolic process (GO:0042436)4.22390794
45indolalkylamine catabolic process (GO:0046218)4.22390794
46tryptophan catabolic process (GO:0006569)4.22390794
47regulation of striated muscle contraction (GO:0006942)4.19613235
48carnitine transmembrane transport (GO:1902603)4.08187830
49gamma-aminobutyric acid transport (GO:0015812)4.04486872
50kynurenine metabolic process (GO:0070189)3.98786393
51regulation of sequestering of triglyceride (GO:0010889)3.97993900
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.97879482
53actin filament-based movement (GO:0030048)3.96780538
54muscle hypertrophy (GO:0014896)3.94540795
55cell communication involved in cardiac conduction (GO:0086065)3.91349592
56regulation of membrane repolarization (GO:0060306)3.87578809
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84779990
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.83104869
59heart contraction (GO:0060047)3.82598967
60heart process (GO:0003015)3.82598967
612-oxoglutarate metabolic process (GO:0006103)3.82532525
62regulation of cofactor metabolic process (GO:0051193)3.79794674
63regulation of coenzyme metabolic process (GO:0051196)3.79794674
64amino-acid betaine transport (GO:0015838)3.74196051
65carnitine transport (GO:0015879)3.74196051
66regulation of the force of heart contraction (GO:0002026)3.72180512
67indolalkylamine metabolic process (GO:0006586)3.69013172
68interkinetic nuclear migration (GO:0022027)3.67392795
69positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.63669618
70regulation of cardiac muscle cell contraction (GO:0086004)3.61630130
71creatine metabolic process (GO:0006600)3.60606367
72sulfation (GO:0051923)3.60486882
73cAMP catabolic process (GO:0006198)3.60314631
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54426946
75cellular ketone body metabolic process (GO:0046950)3.53250442
76regulation of cardiac muscle contraction (GO:0055117)3.50209076
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49320085
78cardiac muscle cell action potential (GO:0086001)3.49033801
79cardiac muscle cell action potential involved in contraction (GO:0086002)3.46625059
80fatty acid beta-oxidation (GO:0006635)3.45731203
81tryptophan metabolic process (GO:0006568)3.43294977
82relaxation of cardiac muscle (GO:0055119)3.42237060
83skeletal muscle contraction (GO:0003009)3.41660129
84fucose catabolic process (GO:0019317)3.40309842
85L-fucose metabolic process (GO:0042354)3.40309842
86L-fucose catabolic process (GO:0042355)3.40309842
87cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.36644425
88lysine catabolic process (GO:0006554)3.35582252
89lysine metabolic process (GO:0006553)3.35582252
90regulation of fatty acid oxidation (GO:0046320)3.35130803
91cyclic nucleotide catabolic process (GO:0009214)3.33311257
92lymphangiogenesis (GO:0001946)3.33283592
93cardiac muscle adaptation (GO:0014887)3.32404983
94cardiac muscle hypertrophy in response to stress (GO:0014898)3.32404983
95muscle hypertrophy in response to stress (GO:0003299)3.32404983
96NADH metabolic process (GO:0006734)3.31249911
97regulation of heart rate (GO:0002027)3.27880672
98cell communication by electrical coupling (GO:0010644)3.27385768
99muscle contraction (GO:0006936)3.26977557
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.26814950
101regulation of sulfur metabolic process (GO:0042762)3.24954913
102regulation of hippo signaling (GO:0035330)3.23627123
103negative regulation of potassium ion transport (GO:0043267)3.23350111
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.21972980
105trabecula formation (GO:0060343)3.20290340
106neuronal action potential (GO:0019228)3.20010884
107aspartate family amino acid catabolic process (GO:0009068)3.19989476
108reflex (GO:0060004)3.19942697
109serotonin metabolic process (GO:0042428)3.16614933
110negative regulation of protein localization to cell surface (GO:2000009)3.15141101
111indole-containing compound metabolic process (GO:0042430)3.12251861
112ketone body metabolic process (GO:1902224)3.10987807
113muscle system process (GO:0003012)3.10125860
114striated muscle adaptation (GO:0014888)3.07653103
115skeletal muscle adaptation (GO:0043501)3.05661757
116primary amino compound metabolic process (GO:1901160)3.04283559
117striated muscle cell development (GO:0055002)3.02198986
118regulation of gene silencing by RNA (GO:0060966)3.01721783
119regulation of posttranscriptional gene silencing (GO:0060147)3.01721783
120regulation of gene silencing by miRNA (GO:0060964)3.01721783
121cardiac conduction (GO:0061337)3.00530861
122glycogen catabolic process (GO:0005980)3.00471602
123behavioral response to ethanol (GO:0048149)2.96455780
124regulation of heart contraction (GO:0008016)2.95209063
125regulation of action potential (GO:0098900)2.94593725
126regulation of cardioblast differentiation (GO:0051890)2.93482118
127positive regulation of fatty acid oxidation (GO:0046321)2.93158810
128fatty acid oxidation (GO:0019395)2.90712163
129positive regulation of heart rate (GO:0010460)2.90704776
130membrane depolarization during action potential (GO:0086010)2.89601909
131response to inactivity (GO:0014854)2.89294664
132succinate metabolic process (GO:0006105)2.87527887
133regulation of muscle contraction (GO:0006937)2.87520087
134amine catabolic process (GO:0009310)2.86995918
135cellular biogenic amine catabolic process (GO:0042402)2.86995918
136negative regulation of sodium ion transport (GO:0010766)2.80347250
137signal peptide processing (GO:0006465)2.78885598
138atrial cardiac muscle cell action potential (GO:0086014)2.77520196
139positive regulation of action potential (GO:0045760)2.75389187
140NAD biosynthetic process (GO:0009435)2.74156925
141oxidative demethylation (GO:0070989)2.70848110
142regulation of mesoderm development (GO:2000380)2.66363412
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66250148
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.62628012
145regulation of translation, ncRNA-mediated (GO:0045974)2.62628012
146negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62628012
147detection of light stimulus involved in sensory perception (GO:0050962)2.58421713
148detection of light stimulus involved in visual perception (GO:0050908)2.58421713
149cellular response to sterol (GO:0036315)2.56649125
150flavonoid metabolic process (GO:0009812)2.54617968
151nephron tubule morphogenesis (GO:0072078)2.52663586
152nephron epithelium morphogenesis (GO:0072088)2.52663586
153action potential (GO:0001508)2.51959572
154drug catabolic process (GO:0042737)2.50758087
155benzene-containing compound metabolic process (GO:0042537)2.50224442
156renal tubule morphogenesis (GO:0061333)2.49728301
157alanine transport (GO:0032328)2.49154447
158peristalsis (GO:0030432)2.48315212
159aromatic amino acid family catabolic process (GO:0009074)2.48062561
160cilium or flagellum-dependent cell motility (GO:0001539)2.44815958
161exogenous drug catabolic process (GO:0042738)2.43118623
162regulation of establishment of cell polarity (GO:2000114)2.42805583
163regulation of establishment or maintenance of cell polarity (GO:0032878)2.42567728
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39732546
165transmission of nerve impulse (GO:0019226)2.39221670
166cochlea development (GO:0090102)2.37694798
167urinary tract smooth muscle contraction (GO:0014848)2.37098536
168response to caffeine (GO:0031000)2.36906697
169kidney morphogenesis (GO:0060993)2.35856177
170inner ear receptor stereocilium organization (GO:0060122)2.35136298
171cell morphogenesis involved in neuron differentiation (GO:0048667)2.34474114
172spinal cord motor neuron differentiation (GO:0021522)2.33568629
173auditory receptor cell stereocilium organization (GO:0060088)2.32814086
174nucleus localization (GO:0051647)2.32805821
175regulation of pigment cell differentiation (GO:0050932)2.32083207
176somite development (GO:0061053)2.30931128
177negative regulation of mast cell activation (GO:0033004)2.30474497
178positive regulation of fatty acid beta-oxidation (GO:0032000)2.29263016
179cardiovascular system development (GO:0072358)2.28898431
180negative regulation of axon guidance (GO:1902668)2.28807027
181proline transport (GO:0015824)2.27200660
182negative regulation of axon extension involved in axon guidance (GO:0048843)2.27045652
183positive regulation of sodium ion transmembrane transport (GO:1902307)2.26138253
184synaptic transmission, cholinergic (GO:0007271)2.24423977
185striated muscle atrophy (GO:0014891)2.24162683
186detection of mechanical stimulus involved in sensory perception (GO:0050974)2.23804663
187presynaptic membrane assembly (GO:0097105)2.23568235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.19605353
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.27596861
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.94947878
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74612756
5GBX2_23144817_ChIP-Seq_PC3_Human3.49315626
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.04662304
7VDR_22108803_ChIP-Seq_LS180_Human3.02655488
8* TBX20_22328084_ChIP-Seq_HEART_Mouse3.02047679
9* TBX20_22080862_ChIP-Seq_HEART_Mouse3.02047679
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.00177456
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95488884
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70729672
13ZNF274_21170338_ChIP-Seq_K562_Hela2.67287559
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55022068
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.49989751
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.44405962
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43985121
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.43547428
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30887191
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28818762
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26452492
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25899677
23CLOCK_20551151_ChIP-Seq_293T_Human2.24992891
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24626578
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18706463
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16194776
27TAF15_26573619_Chip-Seq_HEK293_Human2.07541441
28MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.06258738
29ZNF263_19887448_ChIP-Seq_K562_Human2.00933594
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97854030
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95273151
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92483439
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91166161
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90878306
35P300_19829295_ChIP-Seq_ESCs_Human1.88609663
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.86528304
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85813896
38IGF1R_20145208_ChIP-Seq_DFB_Human1.84937827
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.80777710
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74619252
41ER_23166858_ChIP-Seq_MCF-7_Human1.73348163
42SMAD4_21799915_ChIP-Seq_A2780_Human1.72486861
43* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.71396866
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70018688
45FUS_26573619_Chip-Seq_HEK293_Human1.69842461
46* STAT3_23295773_ChIP-Seq_U87_Human1.69571067
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.68533761
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65293515
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62870252
50EWS_26573619_Chip-Seq_HEK293_Human1.62314755
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62183723
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.61575359
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61208908
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60417436
55AR_25329375_ChIP-Seq_VCAP_Human1.54958909
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.54323874
57TCF4_23295773_ChIP-Seq_U87_Human1.53706300
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53636459
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.53102725
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50696062
61GATA1_22025678_ChIP-Seq_K562_Human1.48543898
62GATA4_21415370_ChIP-Seq_HL-1_Mouse1.48522275
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47088127
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45472501
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43755554
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43755554
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42768053
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42750893
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41847893
70TP53_16413492_ChIP-PET_HCT116_Human1.40858018
71EZH2_22144423_ChIP-Seq_EOC_Human1.40714100
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40594849
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38399639
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37930254
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37579401
76DROSHA_22980978_ChIP-Seq_HELA_Human1.34750899
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33606885
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30476024
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30191774
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29806653
81CJUN_26792858_Chip-Seq_BT549_Human1.26849498
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26759782
83CBP_20019798_ChIP-Seq_JUKART_Human1.26759782
84RUNX2_22187159_ChIP-Seq_PCA_Human1.25786979
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25654993
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24630452
87REST_21632747_ChIP-Seq_MESCs_Mouse1.23131310
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.23051703
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22866251
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.22135260
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.21848191
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21087237
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.20832996
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.17528594
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16132493
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15659221
97TCF4_22108803_ChIP-Seq_LS180_Human1.15490896
98RNF2_27304074_Chip-Seq_NSC_Mouse1.15431616
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.15160177
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14702833
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.14509954
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14502856
103GATA1_19941826_ChIP-Seq_K562_Human1.14169621
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13594850
105NANOG_19829295_ChIP-Seq_ESCs_Human1.13458962
106SOX2_19829295_ChIP-Seq_ESCs_Human1.13458962
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.13385226
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.13307379
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.13282004
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13271627
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12289458
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11527725
113NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11527725
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10881353
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10627985
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10350424
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.08881048
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08617044
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08162338
120KDM2B_26808549_Chip-Seq_REH_Human1.07408456
121RXR_22108803_ChIP-Seq_LS180_Human1.07212403
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07069845
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06129448
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05281971
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.04807382
126KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03065096
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.00080427
128MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00067234
129EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98238503
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98238503
131AR_21572438_ChIP-Seq_LNCaP_Human0.97649558
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94261898
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92656281
134BCAT_22108803_ChIP-Seq_LS180_Human0.92014390
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91730446
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90314095
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89633507
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89535819
139SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89136587
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.88811407
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.88514167
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87810090
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87752825
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.87601006
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87204656
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87060136
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85605460
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85401586
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84776453
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84491635
151* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84319207
152CTCF_27219007_Chip-Seq_Bcells_Human0.81467182
153GATA2_19941826_ChIP-Seq_K562_Human0.80993540
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80841599
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.80836748
156SMAD3_21741376_ChIP-Seq_HESCs_Human0.80207147
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79709367
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79642818
159AHR_22903824_ChIP-Seq_MCF-7_Human0.79325342
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.78685948
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.78547776
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78176384
163SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77777503
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.77252389
165ELK3_25401928_ChIP-Seq_HUVEC_Human0.75093502
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.74395940
167TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74346931
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74021175
169TP63_22573176_ChIP-Seq_HFKS_Human0.72535087
170SMC3_22415368_ChIP-Seq_MEFs_Mouse0.72158434
171SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71945395
172CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71736954
173PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.70901735
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.70428758
175EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69921317
176PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.69138863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.76894639
2MP0004084_abnormal_cardiac_muscle5.09827915
3MP0004215_abnormal_myocardial_fiber4.78195610
4MP0003646_muscle_fatigue4.77734129
5MP0000751_myopathy4.61159413
6MP0004036_abnormal_muscle_relaxation4.06334742
7MP0000749_muscle_degeneration3.62917986
8MP0005330_cardiomyopathy3.52535335
9MP0000569_abnormal_digit_pigmentation3.24196465
10MP0010368_abnormal_lymphatic_system3.23948062
11MP0002972_abnormal_cardiac_muscle2.83699422
12MP0004087_abnormal_muscle_fiber2.83130097
13MP0003136_yellow_coat_color2.75929867
14MP0004145_abnormal_muscle_electrophysio2.72536580
15MP0008775_abnormal_heart_ventricle2.71986182
16* MP0005620_abnormal_muscle_contractility2.66177330
17* MP0004130_abnormal_muscle_cell2.50145132
18MP0000750_abnormal_muscle_regeneration2.49057278
19MP0002106_abnormal_muscle_physiology2.42112057
20MP0010630_abnormal_cardiac_muscle2.40323534
21MP0001544_abnormal_cardiovascular_syste2.37682354
22MP0005385_cardiovascular_system_phenoty2.37682354
23MP0001879_abnormal_lymphatic_vessel2.35656766
24MP0009046_muscle_twitch2.34925162
25MP0004484_altered_response_of2.31575155
26MP0006138_congestive_heart_failure2.25624962
27MP0003828_pulmonary_edema2.25183023
28* MP0003137_abnormal_impulse_conducting2.18315865
29MP0001501_abnormal_sleep_pattern2.14208145
30MP0002269_muscular_atrophy2.09557003
31MP0004085_abnormal_heartbeat2.00844811
32MP0009745_abnormal_behavioral_response1.99502154
33MP0005369_muscle_phenotype1.99206366
34MP0005551_abnormal_eye_electrophysiolog1.98432811
35MP0001485_abnormal_pinna_reflex1.91521757
36MP0000747_muscle_weakness1.85966677
37MP0000759_abnormal_skeletal_muscle1.84811813
38MP0005670_abnormal_white_adipose1.83959684
39MP0000013_abnormal_adipose_tissue1.83229159
40MP0001968_abnormal_touch/_nociception1.83030270
41MP0004142_abnormal_muscle_tone1.76545329
42MP0002127_abnormal_cardiovascular_syste1.74834700
43MP0003283_abnormal_digestive_organ1.68563841
44MP0002638_abnormal_pupillary_reflex1.68460714
45MP0004272_abnormal_basement_membrane1.67101629
46MP0006054_spinal_hemorrhage1.58466084
47MP0005666_abnormal_adipose_tissue1.57688561
48MP0002272_abnormal_nervous_system1.57665937
49MP0002332_abnormal_exercise_endurance1.57542951
50MP0001486_abnormal_startle_reflex1.56263155
51MP0004510_myositis1.55103018
52MP0002735_abnormal_chemical_nociception1.53472257
53MP0000427_abnormal_hair_cycle1.50207671
54MP0002064_seizures1.48939104
55MP0005646_abnormal_pituitary_gland1.47728517
56MP0006036_abnormal_mitochondrial_physio1.44687290
57MP0002736_abnormal_nociception_after1.44362925
58MP0003279_aneurysm1.41964375
59MP0002876_abnormal_thyroid_physiology1.40799747
60MP0004885_abnormal_endolymph1.40255860
61MP0003221_abnormal_cardiomyocyte_apopto1.39667692
62MP0002572_abnormal_emotion/affect_behav1.38221018
63MP0005253_abnormal_eye_physiology1.37121525
64MP0006276_abnormal_autonomic_nervous1.36010954
65MP0004233_abnormal_muscle_weight1.35090261
66MP0008438_abnormal_cutaneous_collagen1.34446604
67MP0008872_abnormal_physiological_respon1.33037785
68MP0002733_abnormal_thermal_nociception1.31667798
69MP0002734_abnormal_mechanical_nocicepti1.30361840
70MP0003890_abnormal_embryonic-extraembry1.28733263
71MP0000383_abnormal_hair_follicle1.28491905
72MP0003950_abnormal_plasma_membrane1.27468382
73MP0005165_increased_susceptibility_to1.27343850
74MP0001970_abnormal_pain_threshold1.24733514
75MP0005375_adipose_tissue_phenotype1.24246626
76MP0008877_abnormal_DNA_methylation1.23815142
77MP0001986_abnormal_taste_sensitivity1.23787869
78MP0000343_altered_response_to1.23780933
79MP0005645_abnormal_hypothalamus_physiol1.22479819
80MP0002938_white_spotting1.22150726
81MP0006072_abnormal_retinal_apoptosis1.22095278
82MP0002067_abnormal_sensory_capabilities1.18802044
83MP0000631_abnormal_neuroendocrine_gland1.16765424
84MP0003119_abnormal_digestive_system1.16481106
85MP0003724_increased_susceptibility_to1.16194740
86MP0004185_abnormal_adipocyte_glucose1.15701744
87MP0003635_abnormal_synaptic_transmissio1.15518250
88MP0004133_heterotaxia1.15443675
89MP0004924_abnormal_behavior1.15036118
90MP0005386_behavior/neurological_phenoty1.15036118
91MP0005174_abnormal_tail_pigmentation1.14534778
92MP0000266_abnormal_heart_morphology1.14217334
93MP0003567_abnormal_fetal_cardiomyocyte1.12742129
94MP0010386_abnormal_urinary_bladder1.12700957
95MP0000003_abnormal_adipose_tissue1.10466791
96MP0002108_abnormal_muscle_morphology1.08974541
97MP0002928_abnormal_bile_duct1.08973329
98MP0005171_absent_coat_pigmentation1.08491752
99MP0003011_delayed_dark_adaptation1.07291884
100MP0005085_abnormal_gallbladder_physiolo1.05149963
101MP0005623_abnormal_meninges_morphology1.01784298
102MP0002063_abnormal_learning/memory/cond1.01563158
103MP0002128_abnormal_blood_circulation1.01159709
104MP0008004_abnormal_stomach_pH1.00178803
105MP0008875_abnormal_xenobiotic_pharmacok0.99728115
106MP0000538_abnormal_urinary_bladder0.96202193
107MP0001984_abnormal_olfaction0.95588097
108MP0002557_abnormal_social/conspecific_i0.95547881
109MP0002102_abnormal_ear_morphology0.94957571
110MP0000026_abnormal_inner_ear0.92563857
111MP0005167_abnormal_blood-brain_barrier0.92367203
112MP0005448_abnormal_energy_balance0.92109413
113MP0000767_abnormal_smooth_muscle0.91917581
114MP0008961_abnormal_basal_metabolism0.90709268
115MP0005275_abnormal_skin_tensile0.90182073
116MP0002909_abnormal_adrenal_gland0.89556707
117MP0004147_increased_porphyrin_level0.89162839
118MP0005423_abnormal_somatic_nervous0.87950490
119MP0001664_abnormal_digestion0.86959128
120MP0001440_abnormal_grooming_behavior0.86400683
121* MP0000230_abnormal_systemic_arterial0.84191843
122MP0003705_abnormal_hypodermis_morpholog0.81562036
123MP0002653_abnormal_ependyma_morphology0.80207192
124MP0004742_abnormal_vestibular_system0.79312687
125MP0002009_preneoplasia0.78894390
126MP0004270_analgesia0.78636953
127MP0003937_abnormal_limbs/digits/tail_de0.77694641
128MP0005195_abnormal_posterior_eye0.77586798
129MP0002971_abnormal_brown_adipose0.76140876
130MP0003566_abnormal_cell_adhesion0.74441290
131MP0003806_abnormal_nucleotide_metabolis0.72194166
132MP0005319_abnormal_enzyme/_coenzyme0.70314914
133MP0005266_abnormal_metabolism0.68618184
134MP0005365_abnormal_bile_salt0.67514866
135MP0006035_abnormal_mitochondrial_morpho0.66275434
136MP0000733_abnormal_muscle_development0.64164362
137MP0002925_abnormal_cardiovascular_devel0.61395067
138MP0009384_cardiac_valve_regurgitation0.60326824
139MP0005360_urolithiasis0.58496419
140MP0010329_abnormal_lipoprotein_level0.58248781
141MP0003252_abnormal_bile_duct0.56501499
142MP0002234_abnormal_pharynx_morphology0.55348981
143* MP0001614_abnormal_blood_vessel0.55013220
144MP0002118_abnormal_lipid_homeostasis0.54500424
145* MP0002078_abnormal_glucose_homeostasis0.50332743
146MP0005332_abnormal_amino_acid0.48384867
147MP0000249_abnormal_blood_vessel0.47794781
148MP0005451_abnormal_body_composition0.46241304
149MP0005187_abnormal_penis_morphology0.45879192
150MP0002139_abnormal_hepatobiliary_system0.45089592
151MP0001784_abnormal_fluid_regulation0.43578492
152* MP0005595_abnormal_vascular_smooth0.42874388
153MP0005503_abnormal_tendon_morphology0.42432416
154MP0002295_abnormal_pulmonary_circulatio0.42277546
155MP0003045_fibrosis0.41637795
156MP0001958_emphysema0.41483504
157MP0003300_gastrointestinal_ulcer0.40672826
158MP0005334_abnormal_fat_pad0.38919555
159MP0001661_extended_life_span0.38860475
160MP0004043_abnormal_pH_regulation0.38735779
161MP0003195_calcinosis0.37768524
162MP0005083_abnormal_biliary_tract0.34951487
163MP0005584_abnormal_enzyme/coenzyme_acti0.34821878
164MP0000609_abnormal_liver_physiology0.34623079
165MP0003191_abnormal_cellular_cholesterol0.33776015

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.50724120
2Exercise-induced myalgia (HP:0003738)6.16141643
3Calf muscle hypertrophy (HP:0008981)6.08791069
4Exercise-induced muscle cramps (HP:0003710)5.95050873
5* Ventricular tachycardia (HP:0004756)5.87659842
6Muscle fiber splitting (HP:0003555)5.81851957
7Muscle hypertrophy of the lower extremities (HP:0008968)5.77566460
8* Atrial fibrillation (HP:0005110)5.09440419
9Myoglobinuria (HP:0002913)5.02165418
10Hyporeflexia of lower limbs (HP:0002600)5.00288827
11Abnormality of the calf musculature (HP:0001430)4.92118527
12* Lipoatrophy (HP:0100578)4.76224148
13Right ventricular cardiomyopathy (HP:0011663)4.74800156
14* Primary atrial arrhythmia (HP:0001692)4.70825054
15Pancreatic cysts (HP:0001737)4.69943523
16Hyperventilation (HP:0002883)4.65442454
17Abnormality of the left ventricular outflow tract (HP:0011103)4.51946865
18Subaortic stenosis (HP:0001682)4.51946865
19* Supraventricular tachycardia (HP:0004755)4.51818211
20Increased connective tissue (HP:0009025)4.50617879
21* Supraventricular arrhythmia (HP:0005115)4.50198434
22Syncope (HP:0001279)4.47534542
23True hermaphroditism (HP:0010459)4.33781669
24Pancreatic fibrosis (HP:0100732)4.25782623
25Genetic anticipation (HP:0003743)4.25443871
26EMG: myopathic abnormalities (HP:0003458)4.14304894
27Abnormality of midbrain morphology (HP:0002418)4.00608589
28Molar tooth sign on MRI (HP:0002419)4.00608589
29* Dilated cardiomyopathy (HP:0001644)3.94703566
30Difficulty running (HP:0009046)3.92699727
31Bundle branch block (HP:0011710)3.90917087
32Rhabdomyolysis (HP:0003201)3.90156118
33Palpitations (HP:0001962)3.89670695
34Prolonged QT interval (HP:0001657)3.83817118
35Progressive cerebellar ataxia (HP:0002073)3.75788664
36Type 1 muscle fiber predominance (HP:0003803)3.75388140
37Asymmetric septal hypertrophy (HP:0001670)3.69007308
38Ventricular arrhythmia (HP:0004308)3.65018247
39Nephronophthisis (HP:0000090)3.46818663
40Heart block (HP:0012722)3.39983165
41Myotonia (HP:0002486)3.39492330
42Muscle fiber inclusion bodies (HP:0100299)3.38456902
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.32774357
44Atrioventricular block (HP:0001678)3.29817693
45Gaze-evoked nystagmus (HP:0000640)3.28548686
46Protruding tongue (HP:0010808)3.21093592
47Abnormal atrioventricular conduction (HP:0005150)3.20235516
48Cystic liver disease (HP:0006706)3.17531589
49Abnormality of the renal cortex (HP:0011035)3.16016232
50Abnormality of the renal medulla (HP:0100957)3.14707884
51Increased variability in muscle fiber diameter (HP:0003557)3.13174673
52Hypoglycemic coma (HP:0001325)3.12949606
53Clumsiness (HP:0002312)3.12679319
54Ventricular fibrillation (HP:0001663)3.07764694
55Fair hair (HP:0002286)3.05976966
56Inability to walk (HP:0002540)3.05689298
57Congenital stationary night blindness (HP:0007642)3.03031446
58Muscle stiffness (HP:0003552)3.00625213
59Ketoacidosis (HP:0001993)2.97500292
60Abnormality of skeletal muscle fiber size (HP:0012084)2.92305567
61Attenuation of retinal blood vessels (HP:0007843)2.90079201
62Keratoconus (HP:0000563)2.85880691
63Increased corneal curvature (HP:0100692)2.85880691
64Type II lissencephaly (HP:0007260)2.84802016
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.82622755
66Medial flaring of the eyebrow (HP:0010747)2.78379241
67Difficulty climbing stairs (HP:0003551)2.75559392
68Abnormal EKG (HP:0003115)2.68598854
69Nemaline bodies (HP:0003798)2.68395539
70Abnormality of fatty-acid metabolism (HP:0004359)2.66071103
71Hemiparesis (HP:0001269)2.64253736
72Chronic hepatic failure (HP:0100626)2.62317232
73Broad-based gait (HP:0002136)2.60739591
74Tubular atrophy (HP:0000092)2.58760101
75Birth length less than 3rd percentile (HP:0003561)2.57536801
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51391745
77Dicarboxylic aciduria (HP:0003215)2.51391745
78Abolished electroretinogram (ERG) (HP:0000550)2.50518676
79Hepatic necrosis (HP:0002605)2.49075394
80Febrile seizures (HP:0002373)2.48536638
81* Furrowed tongue (HP:0000221)2.46696758
82Lymphangioma (HP:0100764)2.45599794
83Congenital hepatic fibrosis (HP:0002612)2.44146742
84Areflexia of lower limbs (HP:0002522)2.42902391
85Hypoalphalipoproteinemia (HP:0003233)2.42755766
86Ketosis (HP:0001946)2.42090452
87Congenital sensorineural hearing impairment (HP:0008527)2.41349851
88Distal lower limb muscle weakness (HP:0009053)2.41179229
89Neck muscle weakness (HP:0000467)2.40473618
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.39898456
91Decreased circulating renin level (HP:0003351)2.38101444
92Progressive inability to walk (HP:0002505)2.37878095
93Gait imbalance (HP:0002141)2.32883237
94Sclerocornea (HP:0000647)2.32672464
95Generalized hypopigmentation of hair (HP:0011358)2.31450723
96Facial diplegia (HP:0001349)2.28977450
97Chorioretinal atrophy (HP:0000533)2.25864302
98* Left ventricular hypertrophy (HP:0001712)2.22439593
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.21644637
100Absent/shortened dynein arms (HP:0200106)2.21644637
101Anencephaly (HP:0002323)2.21053848
102Congenital primary aphakia (HP:0007707)2.18897089
103Pheochromocytoma (HP:0002666)2.18320070
104* Palmoplantar keratoderma (HP:0000982)2.17719567
105Nonimmune hydrops fetalis (HP:0001790)2.17299228
106Genital tract atresia (HP:0001827)2.16921778
107Abnormal mitochondria in muscle tissue (HP:0008316)2.14180703
108Diplopia (HP:0000651)2.13769089
109Abnormality of binocular vision (HP:0011514)2.13769089
110Male pseudohermaphroditism (HP:0000037)2.13745660
111Renal cortical cysts (HP:0000803)2.13401917
112Mesangial abnormality (HP:0001966)2.13145799
113Mildly elevated creatine phosphokinase (HP:0008180)2.13139120
114Testicular atrophy (HP:0000029)2.13109580
115Vaginal atresia (HP:0000148)2.12340705
116Rimmed vacuoles (HP:0003805)2.11789966
117Absent speech (HP:0001344)2.11432700
118Patellar aplasia (HP:0006443)2.09335802
119Polydipsia (HP:0001959)2.09290333
120Abnormal drinking behavior (HP:0030082)2.09290333
121Cerebral edema (HP:0002181)2.08268958
122Round ear (HP:0100830)2.08092163
123Hyperinsulinemic hypoglycemia (HP:0000825)2.07477756
124Increased muscle lipid content (HP:0009058)2.06470523
125Generalized muscle weakness (HP:0003324)2.05671144
126Hyperammonemia (HP:0001987)2.05354191
127Sudden cardiac death (HP:0001645)2.04291335
128Acute necrotizing encephalopathy (HP:0006965)2.03896254
129Distal arthrogryposis (HP:0005684)2.02910863
130Hemiplegia (HP:0002301)2.02560961
131Hyperglycemia (HP:0003074)2.02526607
132Conjunctival hamartoma (HP:0100780)2.02506406
133Focal motor seizures (HP:0011153)2.01584692
134Toxemia of pregnancy (HP:0100603)2.00549689
135Muscular dystrophy (HP:0003560)1.99932281
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99719514
137Blue irides (HP:0000635)1.98987605
138Cerebellar dysplasia (HP:0007033)1.98890882
139Widely spaced teeth (HP:0000687)1.98739010
140Stomach cancer (HP:0012126)1.97348138
141Limb-girdle muscle atrophy (HP:0003797)1.97199395
142* Congestive heart failure (HP:0001635)1.94392418
143Ragged-red muscle fibers (HP:0003200)1.93790404
144EMG: neuropathic changes (HP:0003445)1.93661999
145Acute encephalopathy (HP:0006846)1.93524338
146Hepatocellular necrosis (HP:0001404)1.93401345
147Severe muscular hypotonia (HP:0006829)1.93329685
148Long nose (HP:0003189)1.91949393
149Aplasia/Hypoplasia of the patella (HP:0006498)1.90967382
150Dialeptic seizures (HP:0011146)1.90530272
151Focal seizures (HP:0007359)1.90066116
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88857691
153* Prominent supraorbital ridges (HP:0000336)1.88737848
154Insulin-resistant diabetes mellitus (HP:0000831)1.88260524
155Nephrogenic diabetes insipidus (HP:0009806)1.88210732
156Concave nail (HP:0001598)1.85091068
157Hyperglycinuria (HP:0003108)1.85074655
158Bulbous nose (HP:0000414)1.83665818
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83605776
160Abnormality of alanine metabolism (HP:0010916)1.83605776
161Hyperalaninemia (HP:0003348)1.83605776
162Bony spicule pigmentary retinopathy (HP:0007737)1.83600589
163Hyperkalemia (HP:0002153)1.82772911
164Abnormal ciliary motility (HP:0012262)1.82084594
165Spinal rigidity (HP:0003306)1.81608981
166Scapular winging (HP:0003691)1.79994603
167Poor coordination (HP:0002370)1.79849856
168Generalized aminoaciduria (HP:0002909)1.79844471
169Neuroendocrine neoplasm (HP:0100634)1.79803224
170Decreased central vision (HP:0007663)1.78478139
171Absence seizures (HP:0002121)1.78348958
172Polycythemia (HP:0001901)1.76315125
173Hypoplastic labia majora (HP:0000059)1.76218310
174Progressive macrocephaly (HP:0004481)1.76075538
175Abnormality of proline metabolism (HP:0010907)1.76005857
176Hydroxyprolinuria (HP:0003080)1.76005857
177Pulmonary artery stenosis (HP:0004415)1.75450257
178Distal lower limb amyotrophy (HP:0008944)1.74247678
179Bile duct proliferation (HP:0001408)1.73860382
180Abnormal biliary tract physiology (HP:0012439)1.73860382
181Lissencephaly (HP:0001339)1.73070154
182Bone cyst (HP:0012062)1.72920152
183Nausea (HP:0002018)1.72849559
184Gowers sign (HP:0003391)1.72617098
185Hamartoma of the eye (HP:0010568)1.68250819
186Central scotoma (HP:0000603)1.66923936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.11762265
2KDR5.18982207
3TTN5.05679615
4TIE14.86654776
5OBSCN4.63972710
6BMPR1B3.70117142
7ACVR1B3.60710664
8PHKG13.52495655
9PHKG23.52495655
10MYLK3.47760945
11ADRBK22.87769325
12LMTK22.86231720
13DMPK2.80965001
14PDK32.78128144
15PDK42.78128144
16PNCK2.49716737
17PKN22.30768691
18BCKDK2.24038271
19PDK22.02052388
20TRIB31.92677845
21PIK3CA1.89353755
22NTRK31.83374566
23MAPK131.70566664
24TGFBR21.69335055
25CASK1.65741555
26MAPK151.64799507
27STK241.64710576
28PINK11.62213228
29WNK31.59023077
30OXSR11.58707261
31ADRBK11.51759892
32INSRR1.46820088
33NEK11.46500254
34MUSK1.46374397
35PDGFRA1.30370086
36MARK11.30266300
37DAPK21.26770473
38MAPK121.15376150
39TNIK1.14362928
40MKNK21.14009652
41GRK71.13492995
42MAP3K41.11090233
43ZAK1.09903683
44MAP3K71.09886236
45PAK31.08074467
46PRKD11.06983805
47MAP4K21.06380867
48PRKAA21.05697626
49NUAK11.05118250
50CAMK41.03516829
51MAP2K31.03507251
52CAMKK21.03314909
53RIPK11.02120041
54TAOK30.97900411
55SIK10.93927865
56CAMK2D0.92515706
57FLT30.89229547
58ILK0.85425650
59PRKAA10.82502046
60ROCK10.82088838
61AKT30.80818345
62PTK2B0.80595584
63CDC42BPA0.76463960
64NTRK20.73425487
65IRAK10.73420804
66PRKCG0.72590546
67PIK3CG0.71807692
68JAK10.71801985
69EPHB10.71092098
70TRPM70.69318619
71NLK0.68017283
72NEK90.66984966
73TLK10.66411677
74ERN10.65838199
75WEE10.64062402
76CAMK1D0.63224669
77EPHB20.61994092
78PKN10.60587840
79STK110.59480142
80FGFR40.59229234
81PTK60.58559118
82STK38L0.57596168
83MAPKAPK50.57330074
84TGFBR10.56949846
85WNK40.56944989
86LATS10.55837714
87SGK20.55212710
88CAMK1G0.52226636
89MAP3K30.50190380
90STK30.49533817
91CAMK2A0.49469100
92FER0.48720137
93CAMK10.47088142
94STK40.45777350
95MAPK70.44478975
96PRKCH0.43804118
97TEC0.43187409
98MELK0.43001569
99PRKACB0.41974870
100CHUK0.41317258
101MAP3K50.41061793
102PRKCE0.40122221
103MAP2K60.39874994
104JAK20.39181934
105DAPK30.38171119
106PRKACG0.38117485
107MAPKAPK30.37896419
108RET0.37634498
109WNK10.36577187
110CAMK2G0.36282385
111PRKG20.36229042
112MAP2K40.33719899
113STK390.33648265
114MAP2K70.33181021
115PDPK10.32641638
116FGFR30.32458312
117PDGFRB0.32302501
118ERBB20.31599094
119RPS6KL10.29904225
120RPS6KC10.29904225
121* PRKACA0.29775066
122KIT0.29733453
123ROCK20.29555814
124STK380.29485438
125NEK20.29395643
126SIK20.28859229
127PRKCZ0.28233765
128FGFR20.28079666
129CAMK2B0.28060524
130CDK30.27835275
131PRKCA0.27411981
132BRSK20.27132444
133EPHA30.27121946
134PRKCQ0.26268832
135SGK2230.26130955
136SGK4940.26130955
137MAPK110.25414049
138AKT20.25249402
139RPS6KA30.24926355
140RPS6KA60.24712885
141PRKG10.24092867
142PAK20.22062028
143PDK10.21462340
144MAP2K10.19949027
145GRK10.19943457
146NME10.19118365
147SGK30.18863877
148MET0.16488959
149MTOR0.14712850

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.06567258
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.82190443
3Propanoate metabolism_Homo sapiens_hsa006403.48816160
4Dilated cardiomyopathy_Homo sapiens_hsa054143.33316963
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31596349
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.26384631
7Fatty acid degradation_Homo sapiens_hsa000713.25404203
8Cardiac muscle contraction_Homo sapiens_hsa042603.17893097
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70653786
10Fatty acid metabolism_Homo sapiens_hsa012122.52245766
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41736439
12Linoleic acid metabolism_Homo sapiens_hsa005912.38541213
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31452583
14Nicotine addiction_Homo sapiens_hsa050332.18517054
15Carbon metabolism_Homo sapiens_hsa012002.16997485
16Phototransduction_Homo sapiens_hsa047442.16510130
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08045423
18Selenocompound metabolism_Homo sapiens_hsa004502.02942183
19Parkinsons disease_Homo sapiens_hsa050121.94455528
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91605875
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86165872
22Oxidative phosphorylation_Homo sapiens_hsa001901.81161641
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79387173
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.79346026
25PPAR signaling pathway_Homo sapiens_hsa033201.77111027
26Pyruvate metabolism_Homo sapiens_hsa006201.76892133
27Morphine addiction_Homo sapiens_hsa050321.73892750
28Histidine metabolism_Homo sapiens_hsa003401.72804433
29Butanoate metabolism_Homo sapiens_hsa006501.68898407
30Taste transduction_Homo sapiens_hsa047421.62316334
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61553729
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56936316
33Arginine biosynthesis_Homo sapiens_hsa002201.52187102
34Fatty acid elongation_Homo sapiens_hsa000621.51800131
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.48903380
36Alzheimers disease_Homo sapiens_hsa050101.48760727
37Tryptophan metabolism_Homo sapiens_hsa003801.44352850
38Ether lipid metabolism_Homo sapiens_hsa005651.42068910
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40934433
40Olfactory transduction_Homo sapiens_hsa047401.38533721
41Chemical carcinogenesis_Homo sapiens_hsa052041.37770181
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36145182
43Serotonergic synapse_Homo sapiens_hsa047261.35525863
44Glutamatergic synapse_Homo sapiens_hsa047241.32769737
45GABAergic synapse_Homo sapiens_hsa047271.31377414
46Viral myocarditis_Homo sapiens_hsa054161.30875170
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27720917
48Insulin resistance_Homo sapiens_hsa049311.26822432
49Retinol metabolism_Homo sapiens_hsa008301.26312854
50Salivary secretion_Homo sapiens_hsa049701.26067041
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20473915
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20347413
53beta-Alanine metabolism_Homo sapiens_hsa004101.15607618
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.15077411
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11188762
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09240640
57Focal adhesion_Homo sapiens_hsa045101.06952532
58Huntingtons disease_Homo sapiens_hsa050161.06309796
59Glucagon signaling pathway_Homo sapiens_hsa049221.03186886
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02070781
61ECM-receptor interaction_Homo sapiens_hsa045120.97359036
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96726515
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96518356
64Lysine degradation_Homo sapiens_hsa003100.96392391
65Cocaine addiction_Homo sapiens_hsa050300.95891049
66Complement and coagulation cascades_Homo sapiens_hsa046100.95321023
67Peroxisome_Homo sapiens_hsa041460.93826398
68Biosynthesis of amino acids_Homo sapiens_hsa012300.93136374
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91231104
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90340180
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.89928026
72Long-term depression_Homo sapiens_hsa047300.87140809
73Cholinergic synapse_Homo sapiens_hsa047250.86718383
74Insulin signaling pathway_Homo sapiens_hsa049100.86425917
75Arachidonic acid metabolism_Homo sapiens_hsa005900.83188384
76Fatty acid biosynthesis_Homo sapiens_hsa000610.83179980
77Phenylalanine metabolism_Homo sapiens_hsa003600.79854054
78Nitrogen metabolism_Homo sapiens_hsa009100.79686206
79Arginine and proline metabolism_Homo sapiens_hsa003300.79347968
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.79322749
81AMPK signaling pathway_Homo sapiens_hsa041520.78224774
82Calcium signaling pathway_Homo sapiens_hsa040200.73991275
83Amphetamine addiction_Homo sapiens_hsa050310.73728014
84Dopaminergic synapse_Homo sapiens_hsa047280.72558384
85Bile secretion_Homo sapiens_hsa049760.71116063
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70991455
87Mineral absorption_Homo sapiens_hsa049780.69749672
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68773142
89Pancreatic secretion_Homo sapiens_hsa049720.67740576
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66297424
91Oxytocin signaling pathway_Homo sapiens_hsa049210.65292344
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60144176
93Vitamin digestion and absorption_Homo sapiens_hsa049770.60112208
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57397339
95Renin secretion_Homo sapiens_hsa049240.57297631
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56338092
97Adherens junction_Homo sapiens_hsa045200.51542779
98Homologous recombination_Homo sapiens_hsa034400.51254313
99HIF-1 signaling pathway_Homo sapiens_hsa040660.50953437
100Fat digestion and absorption_Homo sapiens_hsa049750.50058159
101Type II diabetes mellitus_Homo sapiens_hsa049300.48954069
102Tight junction_Homo sapiens_hsa045300.48345150
103Amoebiasis_Homo sapiens_hsa051460.45759783
104Tyrosine metabolism_Homo sapiens_hsa003500.44845709
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43437789
106Circadian rhythm_Homo sapiens_hsa047100.42912836
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42883231
108Galactose metabolism_Homo sapiens_hsa000520.42302222
109cAMP signaling pathway_Homo sapiens_hsa040240.42111123
110Thyroid hormone synthesis_Homo sapiens_hsa049180.40128510
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38451076
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38323434
113Ovarian steroidogenesis_Homo sapiens_hsa049130.37778796
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.36594133
115Sulfur relay system_Homo sapiens_hsa041220.35230283
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.34546737
117Gastric acid secretion_Homo sapiens_hsa049710.34447534
118Regulation of autophagy_Homo sapiens_hsa041400.34026922
119Glycerolipid metabolism_Homo sapiens_hsa005610.34003941
120Malaria_Homo sapiens_hsa051440.33973150
121Hedgehog signaling pathway_Homo sapiens_hsa043400.33879433
122TGF-beta signaling pathway_Homo sapiens_hsa043500.33753596
123Caffeine metabolism_Homo sapiens_hsa002320.32185065
124Basal cell carcinoma_Homo sapiens_hsa052170.31781978
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31665922
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30979775
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.30406482
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29824618
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29715876
130Platelet activation_Homo sapiens_hsa046110.29370191
131Insulin secretion_Homo sapiens_hsa049110.28600773
132Dorso-ventral axis formation_Homo sapiens_hsa043200.28349870
133Protein digestion and absorption_Homo sapiens_hsa049740.28200110
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28025319
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27255318
136Fructose and mannose metabolism_Homo sapiens_hsa000510.23506213
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23500962
138Proteoglycans in cancer_Homo sapiens_hsa052050.23362449
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19722939
140* ABC transporters_Homo sapiens_hsa020100.19547396
141Metabolic pathways_Homo sapiens_hsa011000.18811602
142Rap1 signaling pathway_Homo sapiens_hsa040150.17843751
143Circadian entrainment_Homo sapiens_hsa047130.17354837
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16337181
145Notch signaling pathway_Homo sapiens_hsa043300.15620011
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15188052
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.14349976
148Staphylococcus aureus infection_Homo sapiens_hsa051500.13873395

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »