ABCC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.05926403
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.47474329
3peptide hormone processing (GO:0016486)6.43060675
4protein maturation by protein folding (GO:0022417)6.33919377
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.32992062
6COPII vesicle coating (GO:0048208)6.18080013
7glandular epithelial cell differentiation (GO:0002067)5.79294704
8regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.69561486
9type B pancreatic cell development (GO:0003323)5.67655079
10protein retention in ER lumen (GO:0006621)5.62852446
11regulation of type B pancreatic cell apoptotic process (GO:2000674)5.54709827
12positive regulation of insulin secretion (GO:0032024)5.39248519
13glandular epithelial cell development (GO:0002068)5.38607508
14negative regulation of hormone biosynthetic process (GO:0032353)5.33292554
15insulin secretion (GO:0030073)5.33292374
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.27874389
17positive regulation of nuclease activity (GO:0032075)5.01231300
18exocrine pancreas development (GO:0031017)4.99369560
19negative regulation of gluconeogenesis (GO:0045721)4.80798504
20L-alpha-amino acid transmembrane transport (GO:1902475)4.77293977
21vesicle coating (GO:0006901)4.76062353
22negative regulation of protein oligomerization (GO:0032460)4.69936534
23negative regulation of hormone metabolic process (GO:0032351)4.65641864
24sequestering of metal ion (GO:0051238)4.65169465
25regulation of nuclease activity (GO:0032069)4.56979353
26fatty acid homeostasis (GO:0055089)4.51469722
27* regulation of insulin secretion (GO:0050796)4.50805976
28detection of calcium ion (GO:0005513)4.46842210
29positive regulation of respiratory burst (GO:0060267)4.46632327
30positive regulation of peptide hormone secretion (GO:0090277)4.35483510
31endoplasmic reticulum unfolded protein response (GO:0030968)4.31969654
32signal peptide processing (GO:0006465)4.28702657
33ER overload response (GO:0006983)4.26954148
34cellular response to unfolded protein (GO:0034620)4.24542285
35synaptic vesicle docking involved in exocytosis (GO:0016081)4.24255984
36positive regulation of peptide secretion (GO:0002793)4.22274089
37columnar/cuboidal epithelial cell development (GO:0002066)4.17740909
38negative regulation of acute inflammatory response (GO:0002674)4.15352074
39cellular response to topologically incorrect protein (GO:0035967)4.13180636
40lactate metabolic process (GO:0006089)4.12829125
41peptide hormone secretion (GO:0030072)4.12754443
42* regulation of peptide hormone secretion (GO:0090276)4.10044831
43cellular response to vitamin D (GO:0071305)4.09506086
44ER-nucleus signaling pathway (GO:0006984)4.05980973
45nitric oxide mediated signal transduction (GO:0007263)4.03398437
46peptide secretion (GO:0002790)4.03398070
47intra-Golgi vesicle-mediated transport (GO:0006891)4.03383664
48* regulation of peptide secretion (GO:0002791)4.03095035
49cellular ketone body metabolic process (GO:0046950)3.94326148
50negative regulation of glycogen metabolic process (GO:0070874)3.90625828
51toxin metabolic process (GO:0009404)3.84524941
52growth hormone secretion (GO:0030252)3.81555690
53epithelial cell fate commitment (GO:0072148)3.79450654
54ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.77272911
55regulation of glucocorticoid secretion (GO:2000849)3.75980293
56glycerophospholipid catabolic process (GO:0046475)3.73696855
57negative regulation of insulin secretion (GO:0046676)3.68928974
58astrocyte differentiation (GO:0048708)3.67517690
59inositol phosphate catabolic process (GO:0071545)3.67495810
60nucleoside diphosphate catabolic process (GO:0009134)3.63314659
61positive regulation of glycogen biosynthetic process (GO:0045725)3.60564889
62negative regulation of glycoprotein biosynthetic process (GO:0010561)3.59646663
63* regulation of hormone secretion (GO:0046883)3.54067654
64macroautophagy (GO:0016236)3.53115171
65positive regulation of protein autophosphorylation (GO:0031954)3.52739653
66positive regulation of neurotransmitter transport (GO:0051590)3.50071789
67dendritic spine morphogenesis (GO:0060997)3.48565630
68protein localization to Golgi apparatus (GO:0034067)3.46773440
69ketone body metabolic process (GO:1902224)3.46191043
70response to endoplasmic reticulum stress (GO:0034976)3.45307438
71cellular response to hepatocyte growth factor stimulus (GO:0035729)3.44171525
72response to hepatocyte growth factor (GO:0035728)3.44171525
73negative regulation of catecholamine secretion (GO:0033604)3.43255837
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41479806
75inositol phosphate dephosphorylation (GO:0046855)3.40889892
76phosphorylated carbohydrate dephosphorylation (GO:0046838)3.40889892
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40187597
78positive regulation of hormone secretion (GO:0046887)3.39898023
79ER to Golgi vesicle-mediated transport (GO:0006888)3.37222432
80negative regulation of norepinephrine secretion (GO:0010700)3.36656926
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.35967797
82negative regulation of neurological system process (GO:0031645)3.35962311
83protein N-linked glycosylation via asparagine (GO:0018279)3.34200777
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33790000
85peptidyl-asparagine modification (GO:0018196)3.32898645
86positive regulation of nitric-oxide synthase activity (GO:0051000)3.30881922
87chemosensory behavior (GO:0007635)3.30027196
88cellular response to glucagon stimulus (GO:0071377)3.29998477
89* regulation of peptide transport (GO:0090087)3.29577797
90response to unfolded protein (GO:0006986)3.28840399
91righting reflex (GO:0060013)3.27431403
92hormone secretion (GO:0046879)3.26288586
93synaptic vesicle maturation (GO:0016188)3.24810382
94positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.24523947
95positive regulation of macroautophagy (GO:0016239)3.23748435
96inner ear receptor cell development (GO:0060119)3.23523417
97peptide transport (GO:0015833)3.22512037
98protein targeting to Golgi (GO:0000042)3.21794769
99cerebellar Purkinje cell layer development (GO:0021680)3.21560803
100neuromuscular process controlling posture (GO:0050884)3.20909813
101negative regulation of peptide hormone secretion (GO:0090278)3.20645649
102response to topologically incorrect protein (GO:0035966)3.20004598
103regulation of energy homeostasis (GO:2000505)3.19092640
104zinc ion homeostasis (GO:0055069)3.18711970
105regulation of glucocorticoid metabolic process (GO:0031943)3.18365199
106Golgi organization (GO:0007030)3.17907136
107response to hexose (GO:0009746)3.14720103
108response to glucose (GO:0009749)3.11986768
109response to ischemia (GO:0002931)3.11318316
110positive regulation of glycogen metabolic process (GO:0070875)3.09618440
111negative regulation of peptide secretion (GO:0002792)3.09543420
112hormone transport (GO:0009914)3.06693225
113positive regulation of insulin receptor signaling pathway (GO:0046628)3.04362740
114protein N-linked glycosylation (GO:0006487)3.04174242
115positive regulation of neurotransmitter secretion (GO:0001956)3.03795983
116regulation of glycolytic process (GO:0006110)3.02008273
117regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.01082984
118glucose homeostasis (GO:0042593)2.99876413
119carbohydrate homeostasis (GO:0033500)2.99876413
120regulation of corticosteroid hormone secretion (GO:2000846)2.99508574
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.99196269
122regulation of Golgi to plasma membrane protein transport (GO:0042996)2.99164256
123positive regulation of glycolytic process (GO:0045821)2.98955363
124membrane repolarization during action potential (GO:0086011)2.98076463
125response to monosaccharide (GO:0034284)2.98021777
126calcium ion import (GO:0070509)2.97657971
127cellular zinc ion homeostasis (GO:0006882)2.95888769
128regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94955331
129response to dietary excess (GO:0002021)2.94314998
130protein autoprocessing (GO:0016540)2.94100623
131response to lipoprotein particle (GO:0055094)2.89064757
132positive regulation of response to nutrient levels (GO:0032109)2.88076757
133positive regulation of response to extracellular stimulus (GO:0032106)2.88076757
134negative regulation of bone resorption (GO:0045779)2.87366456
135cellular response to hexose stimulus (GO:0071331)2.86400819
136Golgi vesicle transport (GO:0048193)2.84160444
137establishment of protein localization to Golgi (GO:0072600)2.83640128
138regulation of steroid hormone biosynthetic process (GO:0090030)2.83520603
139proline transport (GO:0015824)2.83143539
140regulation of glucokinase activity (GO:0033131)2.81355032
141regulation of hexokinase activity (GO:1903299)2.81355032
142polyol catabolic process (GO:0046174)2.78332923
143respiratory chain complex IV assembly (GO:0008535)2.74055995
144startle response (GO:0001964)2.73704812
145retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73255806
146water-soluble vitamin biosynthetic process (GO:0042364)2.73035914
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72641567
148neurotransmitter secretion (GO:0007269)2.72054743
149calcium ion-dependent exocytosis (GO:0017156)2.71894759
150positive regulation of vasodilation (GO:0045909)2.71230074
151cAMP-mediated signaling (GO:0019933)2.70961748
152alanine transport (GO:0032328)2.70673212
153regulation of autophagic vacuole assembly (GO:2000785)2.69266131
154signal release (GO:0023061)2.66399417
155regulation of acrosome reaction (GO:0060046)2.64889983
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63372693
157regulation of transmission of nerve impulse (GO:0051969)2.61668773
158COPI coating of Golgi vesicle (GO:0048205)10.3106949
159Golgi transport vesicle coating (GO:0048200)10.3106949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.38189918
2GATA1_22025678_ChIP-Seq_K562_Human4.50843249
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.40913425
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.97431359
5IGF1R_20145208_ChIP-Seq_DFB_Human2.25345679
6REST_21632747_ChIP-Seq_MESCs_Mouse2.14629259
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01990923
8NR3C1_23031785_ChIP-Seq_PC12_Mouse1.93400642
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87769502
10REST_18959480_ChIP-ChIP_MESCs_Mouse1.81929479
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77712759
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75251455
13ZNF274_21170338_ChIP-Seq_K562_Hela1.74245441
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73550426
15RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68437240
16OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.67373196
17CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66079732
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65173380
19HTT_18923047_ChIP-ChIP_STHdh_Human1.63474945
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63303831
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61381593
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60123839
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59553514
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57367741
25AR_25329375_ChIP-Seq_VCAP_Human1.56127233
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50118037
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48397157
28P300_19829295_ChIP-Seq_ESCs_Human1.48376514
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47491656
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47267314
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45635371
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.44000464
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43552963
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.42669515
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42364691
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42233614
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.42225187
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41287606
39TAF15_26573619_Chip-Seq_HEK293_Human1.39997106
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.38880129
41EZH2_22144423_ChIP-Seq_EOC_Human1.37426707
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37117820
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36559232
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.36233150
45DROSHA_22980978_ChIP-Seq_HELA_Human1.35993214
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35525170
47STAT3_23295773_ChIP-Seq_U87_Human1.34583387
48REST_19997604_ChIP-ChIP_NEURONS_Mouse1.33853986
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31732480
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31575076
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.31184345
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29956205
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28404372
54GATA1_19941826_ChIP-Seq_K562_Human1.28328838
55ER_23166858_ChIP-Seq_MCF-7_Human1.27321584
56FUS_26573619_Chip-Seq_HEK293_Human1.26035677
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24458485
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24353873
59FOXA1_25552417_ChIP-Seq_VCAP_Human1.23076931
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23030032
61P53_22387025_ChIP-Seq_ESCs_Mouse1.20288522
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19871532
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19304932
64CBP_20019798_ChIP-Seq_JUKART_Human1.19304932
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19095454
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.18271017
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18156942
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.17157311
69VDR_22108803_ChIP-Seq_LS180_Human1.14172347
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12782040
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12693236
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12333801
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.11795137
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11437506
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11241211
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.09918165
77* CDX2_22108803_ChIP-Seq_LS180_Human1.09903510
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09696386
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09358775
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.09176527
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08713972
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.08706264
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08483871
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08033033
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07597099
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07561511
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.07217981
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07005210
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.06833775
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06323956
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.05721754
92GBX2_23144817_ChIP-Seq_PC3_Human1.05580153
93SOX2_19829295_ChIP-Seq_ESCs_Human1.05522935
94NANOG_19829295_ChIP-Seq_ESCs_Human1.05522935
95TCF4_22108803_ChIP-Seq_LS180_Human1.05255902
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05226765
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.04714993
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04586703
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04460715
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.04225077
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03972629
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03834545
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03740107
104TFEB_21752829_ChIP-Seq_HELA_Human1.03187866
105TBL1_22424771_ChIP-Seq_293T_Human1.03152111
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.02761242
107RNF2_27304074_Chip-Seq_NSC_Mouse1.02494952
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02396745
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01920828
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01675131
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01640978
112* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01597296
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01191532
114SMAD4_21799915_ChIP-Seq_A2780_Human0.99413424
115AR_19668381_ChIP-Seq_PC3_Human0.98852259
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.98228415
117RNF2_27304074_Chip-Seq_ESCs_Mouse0.97847630
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.97396471
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97396471
120P300_18555785_Chip-Seq_ESCs_Mouse0.96609872
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95958165
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.95783409
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95681135
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94422330
125* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93526468
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91995975
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90890924
128* TP53_22573176_ChIP-Seq_HFKS_Human0.90422321
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90035530
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89801601
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.88645652
132BCAT_22108803_ChIP-Seq_LS180_Human0.88062463
133TCF4_23295773_ChIP-Seq_U87_Human0.87565954
134ERG_20517297_ChIP-Seq_VCAP_Human0.86511624
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86444673
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86318501
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86264889
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86031857
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.85552240
140POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84692769
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.84608091
142JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84495299
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84342939
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.84024221
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83840053
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83663906
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.83563639
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.83563639
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81999871
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81169468
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79953014
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79782509
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.79647843
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.79155008
155CREB1_26743006_Chip-Seq_LNCaP_Human0.78482095
156MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78357082
157GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78270973
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77986815
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77779407
160KDM2B_26808549_Chip-Seq_K562_Human0.76844780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.00393149
2MP0003283_abnormal_digestive_organ4.87257282
3MP0000013_abnormal_adipose_tissue4.55535073
4MP0002909_abnormal_adrenal_gland4.35880935
5MP0003195_calcinosis4.10194195
6* MP0002693_abnormal_pancreas_physiology4.06475621
7MP0004043_abnormal_pH_regulation3.96929525
8MP0009780_abnormal_chondrocyte_physiolo3.87149267
9MP0001944_abnormal_pancreas_morphology3.84968983
10MP0003183_abnormal_peptide_metabolism3.44586403
11MP0005379_endocrine/exocrine_gland_phen3.44333675
12MP0000678_abnormal_parathyroid_gland3.20001755
13MP0010386_abnormal_urinary_bladder3.06354599
14MP0002837_dystrophic_cardiac_calcinosis2.97897286
15MP0008877_abnormal_DNA_methylation2.65649594
16MP0005220_abnormal_exocrine_pancreas2.62623214
17MP0000003_abnormal_adipose_tissue2.47295905
18MP0009046_muscle_twitch2.44979704
19MP0005645_abnormal_hypothalamus_physiol2.42868361
20MP0002822_catalepsy2.35665190
21* MP0002078_abnormal_glucose_homeostasis2.31383627
22MP0010234_abnormal_vibrissa_follicle2.19079797
23MP0001986_abnormal_taste_sensitivity2.18845058
24MP0003122_maternal_imprinting2.10892410
25MP0006072_abnormal_retinal_apoptosis2.04784309
26MP0004264_abnormal_extraembryonic_tissu2.00194001
27MP0002234_abnormal_pharynx_morphology1.85615622
28MP0002638_abnormal_pupillary_reflex1.84425748
29MP0004270_analgesia1.82320163
30MP0008961_abnormal_basal_metabolism1.72467438
31MP0005646_abnormal_pituitary_gland1.68538264
32MP0002064_seizures1.63183547
33MP0001765_abnormal_ion_homeostasis1.60325792
34MP0002928_abnormal_bile_duct1.57580979
35MP0004859_abnormal_synaptic_plasticity1.57487303
36MP0009745_abnormal_behavioral_response1.57478362
37MP0002896_abnormal_bone_mineralization1.52366280
38MP0002102_abnormal_ear_morphology1.51939057
39MP0003172_abnormal_lysosome_physiology1.48968412
40MP0004510_myositis1.48177929
41MP0003300_gastrointestinal_ulcer1.46851571
42MP0003953_abnormal_hormone_level1.45167940
43MP0001984_abnormal_olfaction1.38684604
44MP0000462_abnormal_digestive_system1.36588557
45MP0000613_abnormal_salivary_gland1.27375234
46MP0003880_abnormal_central_pattern1.24985133
47MP0003959_abnormal_lean_body1.23958399
48MP0002090_abnormal_vision1.23765091
49MP0004145_abnormal_muscle_electrophysio1.22386380
50MP0005257_abnormal_intraocular_pressure1.21458585
51MP0002572_abnormal_emotion/affect_behav1.19503685
52MP0001501_abnormal_sleep_pattern1.18801593
53MP0003868_abnormal_feces_composition1.16982867
54MP0002138_abnormal_hepatobiliary_system1.14705793
55MP0003787_abnormal_imprinting1.14012232
56MP0005375_adipose_tissue_phenotype1.13486368
57MP0010329_abnormal_lipoprotein_level1.13242509
58MP0005551_abnormal_eye_electrophysiolog1.12909840
59MP0001756_abnormal_urination1.12302716
60MP0003252_abnormal_bile_duct1.10197276
61MP0005058_abnormal_lysosome_morphology1.08734917
62MP0002063_abnormal_learning/memory/cond1.08363032
63MP0009643_abnormal_urine_homeostasis1.07771424
64MP0005535_abnormal_body_temperature1.07718449
65MP0004885_abnormal_endolymph1.07517890
66MP0000631_abnormal_neuroendocrine_gland1.05321912
67MP0005332_abnormal_amino_acid1.04981137
68MP0005386_behavior/neurological_phenoty1.04627663
69MP0004924_abnormal_behavior1.04627663
70MP0002163_abnormal_gland_morphology1.03090752
71MP0005365_abnormal_bile_salt1.02107739
72MP0003011_delayed_dark_adaptation1.01140910
73MP0003119_abnormal_digestive_system1.00699540
74MP0001270_distended_abdomen1.00374097
75MP0005075_abnormal_melanosome_morpholog1.00347317
76MP0003045_fibrosis0.99759147
77MP0006054_spinal_hemorrhage0.97343078
78MP0001486_abnormal_startle_reflex0.94896993
79MP0002229_neurodegeneration0.93191211
80MP0001905_abnormal_dopamine_level0.91286506
81MP0005310_abnormal_salivary_gland0.90242841
82MP0006276_abnormal_autonomic_nervous0.89786682
83MP0002876_abnormal_thyroid_physiology0.88692120
84MP0000230_abnormal_systemic_arterial0.88394815
85MP0001502_abnormal_circadian_rhythm0.88171478
86MP0002734_abnormal_mechanical_nocicepti0.85654328
87MP0005448_abnormal_energy_balance0.85408163
88MP0003879_abnormal_hair_cell0.85115625
89MP0001299_abnormal_eye_distance/0.83388982
90MP0005636_abnormal_mineral_homeostasis0.81883705
91MP0004036_abnormal_muscle_relaxation0.81873489
92MP0005187_abnormal_penis_morphology0.80859355
93MP0010678_abnormal_skin_adnexa0.79154401
94MP0001440_abnormal_grooming_behavior0.78565609
95MP0002733_abnormal_thermal_nociception0.78179624
96MP0004142_abnormal_muscle_tone0.77746978
97MP0005367_renal/urinary_system_phenotyp0.76770661
98MP0000516_abnormal_urinary_system0.76770661
99MP0006292_abnormal_olfactory_placode0.74794275
100MP0000639_abnormal_adrenal_gland0.74668435
101MP0002184_abnormal_innervation0.72804192
102MP0005253_abnormal_eye_physiology0.72123893
103MP0009672_abnormal_birth_weight0.71968592
104MP0000427_abnormal_hair_cycle0.71606655
105MP0003690_abnormal_glial_cell0.71556272
106MP0002067_abnormal_sensory_capabilities0.69651416
107MP0005670_abnormal_white_adipose0.68963427
108MP0004134_abnormal_chest_morphology0.68419602
109MP0002295_abnormal_pulmonary_circulatio0.68358105
110MP0003866_abnormal_defecation0.68317004
111MP0002971_abnormal_brown_adipose0.66886893
112MP0003890_abnormal_embryonic-extraembry0.66400262
113MP0006036_abnormal_mitochondrial_physio0.66206930
114MP0002069_abnormal_eating/drinking_beha0.65126013
115MP0003631_nervous_system_phenotype0.64624303
116MP0004085_abnormal_heartbeat0.64223815
117MP0000538_abnormal_urinary_bladder0.63432697
118MP0001968_abnormal_touch/_nociception0.62625279
119MP0002938_white_spotting0.62034591
120MP0003121_genomic_imprinting0.61415490
121MP0005334_abnormal_fat_pad0.60906515
122MP0002269_muscular_atrophy0.60374677
123MP0000955_abnormal_spinal_cord0.60295287
124MP0005452_abnormal_adipose_tissue0.59711954
125MP0004019_abnormal_vitamin_homeostasis0.59684236
126MP0009703_decreased_birth_body0.58860355
127MP0002168_other_aberrant_phenotype0.57595371
128MP0001666_abnormal_nutrient_absorption0.56254547
129MP0005084_abnormal_gallbladder_morpholo0.54907154
130MP0001970_abnormal_pain_threshold0.54174593
131MP0003123_paternal_imprinting0.52538208
132MP0003635_abnormal_synaptic_transmissio0.51410444
133MP0000681_abnormal_thyroid_gland0.49930193
134MP0001661_extended_life_span0.49788226
135MP0004084_abnormal_cardiac_muscle0.48977574
136MP0002118_abnormal_lipid_homeostasis0.48750580
137MP0002557_abnormal_social/conspecific_i0.48590574
138MP0002751_abnormal_autonomic_nervous0.47097551
139MP0003633_abnormal_nervous_system0.46903061
140MP0004233_abnormal_muscle_weight0.45362405
141MP0000428_abnormal_craniofacial_morphol0.45345028
142* MP0009642_abnormal_blood_homeostasis0.45335012
143MP0002272_abnormal_nervous_system0.45211234
144MP0004215_abnormal_myocardial_fiber0.44918848

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)8.19504284
2* Hyperinsulinemic hypoglycemia (HP:0000825)6.63347130
3Abnormality of calcium-phosphate metabolism (HP:0100530)5.52492601
4* Symptomatic seizures (HP:0011145)4.77932708
5* Hypoglycemic seizures (HP:0002173)4.64589597
6* Hyperglycemia (HP:0003074)4.54011504
7Decreased circulating renin level (HP:0003351)4.52615621
8Abnormal pancreas size (HP:0012094)4.40752625
9Hypomagnesemia (HP:0002917)4.39710613
10* Hypoglycemic coma (HP:0001325)3.97051026
11* Insulin-resistant diabetes mellitus (HP:0000831)3.90297953
12Agitation (HP:0000713)3.84960849
13Enlarged penis (HP:0000040)3.82623908
14Retinal atrophy (HP:0001105)3.81029409
15Hypokalemia (HP:0002900)3.76681336
16Mucopolysacchariduria (HP:0008155)3.71370362
17Urinary glycosaminoglycan excretion (HP:0003541)3.71370362
18Dysostosis multiplex (HP:0000943)3.67577575
19* Abnormality of the pancreatic islet cells (HP:0006476)3.58667032
20* Abnormality of endocrine pancreas physiology (HP:0012093)3.58667032
21Hyperparathyroidism (HP:0000843)3.55454550
22Abnormality of magnesium homeostasis (HP:0004921)3.45824715
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.44519068
24Abnormality of polysaccharide metabolism (HP:0011012)3.44519068
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.44519068
26* Ketoacidosis (HP:0001993)3.36474321
27Unilateral renal agenesis (HP:0000122)3.25881453
28Hyperthyroidism (HP:0000836)3.24468650
29Hypokinesia (HP:0002375)3.23024595
30* Prominent metopic ridge (HP:0005487)3.22229116
31Generalized aminoaciduria (HP:0002909)3.21743997
32Abnormality of renin-angiotensin system (HP:0000847)3.20612539
33Osteomalacia (HP:0002749)3.19463657
34Abnormality of potassium homeostasis (HP:0011042)3.13566870
35Type I diabetes mellitus (HP:0100651)3.02481521
36Hyperkalemia (HP:0002153)2.95957697
37Conjugated hyperbilirubinemia (HP:0002908)2.95852392
38* Abnormality of the metopic suture (HP:0005556)2.86098626
39Hemiparesis (HP:0001269)2.83697342
40Dysautonomia (HP:0002459)2.83126050
41Papilledema (HP:0001085)2.81454906
42Abnormality of the intrinsic pathway (HP:0010989)2.81350394
43Increased circulating renin level (HP:0000848)2.76184967
44Hyperphosphatemia (HP:0002905)2.72833603
45Congenital malformation of the right heart (HP:0011723)2.72067940
46Double outlet right ventricle (HP:0001719)2.72067940
47Menstrual irregularities (HP:0000858)2.68177789
48Hypercortisolism (HP:0001578)2.65747365
49Pheochromocytoma (HP:0002666)2.62931815
50Exocrine pancreatic insufficiency (HP:0001738)2.53735623
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.52400153
52Hypoplasia of the fovea (HP:0007750)2.52400153
53Diminished movement (HP:0002374)2.50708021
54* Insulin resistance (HP:0000855)2.47340156
55Testicular neoplasm (HP:0010788)2.46149491
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43937705
57Visual hallucinations (HP:0002367)2.43166235
58Hyperactive renin-angiotensin system (HP:0000841)2.42355716
59Congenital glaucoma (HP:0001087)2.40905988
60Abnormality of the fovea (HP:0000493)2.39964865
61Macroorchidism (HP:0000053)2.38464941
62Limb hypertonia (HP:0002509)2.37487375
63Neoplasm of the adrenal cortex (HP:0100641)2.37313192
64* Large for gestational age (HP:0001520)2.37276268
65Hypotension (HP:0002615)2.35608431
66Hepatic necrosis (HP:0002605)2.34911982
67Tetany (HP:0001281)2.34777803
68* Muscular hypotonia of the trunk (HP:0008936)2.32558114
69Methylmalonic acidemia (HP:0002912)2.32236914
70Abdominal distention (HP:0003270)2.31846638
71Tongue fasciculations (HP:0001308)2.31439001
72Restlessness (HP:0000711)2.30597413
73Gout (HP:0001997)2.29485970
74Thoracolumbar scoliosis (HP:0002944)2.28371848
75Hypothermia (HP:0002045)2.25086089
76Neuroendocrine neoplasm (HP:0100634)2.24919710
77Hypophosphatemia (HP:0002148)2.22511477
78Febrile seizures (HP:0002373)2.19732326
79Abnormality of vitamin B metabolism (HP:0004340)2.18959618
80* Pancreatic islet-cell hyperplasia (HP:0004510)2.17098020
81Anxiety (HP:0000739)2.16749498
82Hamartoma of the eye (HP:0010568)2.16655199
83Progressive neurologic deterioration (HP:0002344)2.14425488
84* Late onset (HP:0003584)2.14171803
85Adrenal overactivity (HP:0002717)2.12326500
86Cortical visual impairment (HP:0100704)2.09854096
87Epileptic encephalopathy (HP:0200134)2.09010404
88Skin nodule (HP:0200036)2.08873518
89Growth hormone excess (HP:0000845)2.06594418
90Abnormality of chloride homeostasis (HP:0011422)2.05635063
91* EEG with generalized epileptiform discharges (HP:0011198)2.04359342
92Chronic bronchitis (HP:0004469)2.03273231
93Basal ganglia calcification (HP:0002135)2.02304712
94Hyperphosphaturia (HP:0003109)2.02099965
95Postural tremor (HP:0002174)1.98890857
96Ventricular fibrillation (HP:0001663)1.97789737
97Sex reversal (HP:0012245)1.97337646
98Abnormal sex determination (HP:0012244)1.97337646
99Intestinal atresia (HP:0011100)1.96846581
100* Epileptiform EEG discharges (HP:0011182)1.96352370
101* Hypsarrhythmia (HP:0002521)1.95632760
102Generalized hyperpigmentation (HP:0007440)1.95121959
103Intention tremor (HP:0002080)1.94909025
104Protuberant abdomen (HP:0001538)1.91771341
105Missing ribs (HP:0000921)1.91309576
106Hematochezia (HP:0002573)1.90614641
107Muscle fibrillation (HP:0010546)1.90418209
108Conjunctival hamartoma (HP:0100780)1.89334648
109Gaze-evoked nystagmus (HP:0000640)1.88675484
110Abnormality of the basal ganglia (HP:0002134)1.88136214
111* Ketosis (HP:0001946)1.86399442
112Medial flaring of the eyebrow (HP:0010747)1.85856313
113Abnormal biliary tract morphology (HP:0012440)1.84903678
114Progressive macrocephaly (HP:0004481)1.84599078
115Failure to thrive in infancy (HP:0001531)1.83323282
116Prolonged QT interval (HP:0001657)1.83263420
117Abnormality of liposaccharide metabolism (HP:0010968)1.82956188
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.82956188
119Abnormality of glycolipid metabolism (HP:0010969)1.82956188
120Abnormality of small intestinal villus morphology (HP:0011472)1.82937185
121Villous atrophy (HP:0011473)1.82937185
122Type II lissencephaly (HP:0007260)1.82742594
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82699487
124Abnormal protein N-linked glycosylation (HP:0012347)1.82699487
125Abnormal protein glycosylation (HP:0012346)1.82699487
126Abnormal glycosylation (HP:0012345)1.82699487
127Generalized tonic-clonic seizures (HP:0002069)1.82549536
128Global brain atrophy (HP:0002283)1.82501199
129Poor suck (HP:0002033)1.80342154
130Bundle branch block (HP:0011710)1.80291193
131Severe short stature (HP:0003510)1.79855613
132Polyuria (HP:0000103)1.79325411
133Neoplasm of the heart (HP:0100544)1.76048112
134Orthostatic hypotension (HP:0001278)1.75932498
135Glucose intolerance (HP:0000833)1.75586874
136Tachypnea (HP:0002789)1.75184534
137Metaphyseal dysplasia (HP:0100255)1.75182960
138Abnormal drinking behavior (HP:0030082)1.75118292
139Polydipsia (HP:0001959)1.75118292
140Hepatoblastoma (HP:0002884)1.75049913
141Irregular vertebral endplates (HP:0003301)1.74373676
142Dialeptic seizures (HP:0011146)1.72686713
143Aqueductal stenosis (HP:0002410)1.72029086
144* Downturned corners of mouth (HP:0002714)1.71857986
145Nuclear cataract (HP:0100018)1.69093376
146Akinesia (HP:0002304)1.67958133
147Abnormality of vitamin metabolism (HP:0100508)1.67945023
148Methylmalonic aciduria (HP:0012120)1.67288815
149Hyperventilation (HP:0002883)1.67004288
150Focal seizures (HP:0007359)1.66532668
151Steatorrhea (HP:0002570)1.63225716
152Absence seizures (HP:0002121)1.60705993
153Abnormality of the renal cortex (HP:0011035)1.60466471
154J-shaped sella turcica (HP:0002680)1.59733427
155Nephronophthisis (HP:0000090)1.59471115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.50894963
2MAPK155.17143884
3PASK5.15856682
4TAOK34.21310943
5WNK33.61997772
6DAPK23.45085582
7FGFR23.42300924
8HIPK23.08220525
9PRKD32.90412137
10MAP3K22.66137860
11FRK2.62471092
12PHKG12.59409136
13PHKG22.59409136
14WNK42.48271823
15UHMK11.99668074
16FLT31.93907907
17ERN11.92933382
18PIK3CG1.90393100
19MAP3K11.84697825
20NTRK11.74553194
21TRPM71.73266051
22NTRK31.71138343
23MAP2K61.69495115
24SCYL21.67173992
25CAMKK21.61474149
26PINK11.59017078
27CASK1.58184182
28MST41.56231975
29PDGFRA1.47849023
30MAP3K41.47462169
31CDC42BPA1.44372728
32GRK11.38726410
33IRAK31.32404219
34ADRBK21.30835721
35EPHA31.29633632
36PNCK1.26290297
37STK38L1.26218820
38PRKCH1.24602693
39CSNK1G11.23228597
40TNIK1.23222716
41PTK21.21831649
42DYRK1B1.18488809
43PTK61.14145136
44PLK21.12243023
45TRIB31.12199283
46WNK11.11629358
47PAK31.07477338
48IRAK11.05354541
49PRKAA21.04296789
50MAP3K91.03556179
51BRSK20.99579362
52PRKD20.99539318
53STK110.97749720
54MAP4K20.92890146
55ERBB30.91637068
56AKT30.89163557
57CSNK1G30.82975297
58CSNK1G20.82926017
59STK30.82273209
60YES10.81843014
61MET0.79889036
62EIF2AK30.78703851
63DAPK10.77293235
64PTK2B0.74899846
65OXSR10.74538255
66MAP2K70.73124358
67LIMK10.71747828
68STK390.71415853
69CAMK2D0.71208946
70FER0.70581387
71RET0.69710405
72LMTK20.66620407
73BRD40.65593172
74CAMK10.65169592
75MAP2K20.64836576
76KSR20.64462484
77ACVR1B0.63839475
78BMPR1B0.62477777
79CDK30.61864954
80PRKAA10.61157608
81SIK10.58885433
82PRKCE0.58523257
83NTRK20.57867365
84MAP3K120.57483206
85JAK20.56506486
86MARK20.52603261
87CAMKK10.52555294
88STK380.51621172
89RIPK10.51541354
90CAMK1D0.50701835
91IRAK20.48806305
92STK240.48547873
93MARK10.47064028
94PRKD10.47058444
95PRKCI0.46250319
96ITK0.45534296
97MAP3K70.45317255
98BRAF0.42721507
99MTOR0.41300264
100EPHA20.41066267
101CAMK2A0.40928858
102BRSK10.40849446
103TNK20.40789094
104RPS6KA20.39968892
105TAOK10.39650441
106PRKG10.39446111
107PRKCZ0.38057439
108FGFR40.37767611
109MAPK130.37481120
110ADRBK10.37314142
111PRKACG0.36199754
112CDK50.35962899
113JAK10.34784756
114BCKDK0.34303764
115CAMK2B0.33958859
116SGK2230.33740272
117SGK4940.33740272
118PRKDC0.33627073
119ALK0.32444415
120NLK0.31638848
121DAPK30.31530495
122SGK20.30932745
123MAP3K30.30832197
124GSK3A0.30614521
125PDGFRB0.30343833
126CSNK1A10.29838691
127MAP2K40.29593872
128CSNK1E0.29509139
129CSNK1A1L0.29355864
130DYRK1A0.28435915
131RPS6KB10.26172415
132CAMK1G0.25820549
133LATS10.25544043
134IGF1R0.25120139
135* PRKACA0.24117007
136RPS6KA30.23888673
137MAPK140.23216924
138PRKCG0.22492036
139SGK30.22461026
140NEK60.21797076
141EPHB10.21681961
142MAP2K10.21380450
143SGK10.20992911
144PRKCA0.20353125
145MAPK100.20184127
146BMPR20.20132832
147GRK50.19907034
148FGFR30.19644987
149TESK10.17849700
150PRKCB0.15207695
151ZAP700.15180246
152PDPK10.14624425
153PAK60.14416350
154CHUK0.14376915
155GSK3B0.13984371

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.37423388
2Protein export_Homo sapiens_hsa030604.60000205
3* Insulin secretion_Homo sapiens_hsa049113.37489521
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.06488578
5Sulfur metabolism_Homo sapiens_hsa009202.74205520
6Type I diabetes mellitus_Homo sapiens_hsa049402.55050586
7* Type II diabetes mellitus_Homo sapiens_hsa049302.29473579
8Vitamin B6 metabolism_Homo sapiens_hsa007502.00512185
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00330964
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99662707
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.94924305
12Vibrio cholerae infection_Homo sapiens_hsa051101.87584682
13Cocaine addiction_Homo sapiens_hsa050301.71925225
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62311779
15N-Glycan biosynthesis_Homo sapiens_hsa005101.50618974
16Fatty acid elongation_Homo sapiens_hsa000621.46574915
17Amphetamine addiction_Homo sapiens_hsa050311.45178051
18Pancreatic secretion_Homo sapiens_hsa049721.43753366
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43367111
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.41342260
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40069095
22Taste transduction_Homo sapiens_hsa047421.34938609
23Lysosome_Homo sapiens_hsa041421.34695272
24Selenocompound metabolism_Homo sapiens_hsa004501.33859234
25Circadian rhythm_Homo sapiens_hsa047101.28054542
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27668258
27Glucagon signaling pathway_Homo sapiens_hsa049221.21953432
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15892921
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10559523
30Oxidative phosphorylation_Homo sapiens_hsa001901.06984364
31Thyroid hormone synthesis_Homo sapiens_hsa049181.06197571
32Insulin resistance_Homo sapiens_hsa049311.05524757
33Circadian entrainment_Homo sapiens_hsa047131.04530910
34Other glycan degradation_Homo sapiens_hsa005111.03919825
35Dopaminergic synapse_Homo sapiens_hsa047281.03263627
36Long-term potentiation_Homo sapiens_hsa047201.02790684
37Synaptic vesicle cycle_Homo sapiens_hsa047211.01448357
38Phototransduction_Homo sapiens_hsa047440.97608870
39Mineral absorption_Homo sapiens_hsa049780.97484220
40Nicotine addiction_Homo sapiens_hsa050330.97032755
41GABAergic synapse_Homo sapiens_hsa047270.96769397
42Fatty acid metabolism_Homo sapiens_hsa012120.95842616
43Regulation of autophagy_Homo sapiens_hsa041400.94761099
44Cholinergic synapse_Homo sapiens_hsa047250.91753720
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89872791
46Estrogen signaling pathway_Homo sapiens_hsa049150.85634374
47beta-Alanine metabolism_Homo sapiens_hsa004100.84880624
48Prolactin signaling pathway_Homo sapiens_hsa049170.83626031
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82922242
50Prion diseases_Homo sapiens_hsa050200.82781854
51Serotonergic synapse_Homo sapiens_hsa047260.82121828
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81527387
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78413348
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74618989
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.74610580
56Renin secretion_Homo sapiens_hsa049240.73000703
57Peroxisome_Homo sapiens_hsa041460.71842135
58Ether lipid metabolism_Homo sapiens_hsa005650.69454792
59Morphine addiction_Homo sapiens_hsa050320.68528813
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65462320
61Cardiac muscle contraction_Homo sapiens_hsa042600.64937886
62Folate biosynthesis_Homo sapiens_hsa007900.64932686
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64638116
64Fatty acid degradation_Homo sapiens_hsa000710.64432994
65Collecting duct acid secretion_Homo sapiens_hsa049660.64317311
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64132514
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62473600
68Galactose metabolism_Homo sapiens_hsa000520.62354033
69Insulin signaling pathway_Homo sapiens_hsa049100.62285248
70Propanoate metabolism_Homo sapiens_hsa006400.60518136
71cAMP signaling pathway_Homo sapiens_hsa040240.58421552
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57942483
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57652121
74Bile secretion_Homo sapiens_hsa049760.56188180
75Tryptophan metabolism_Homo sapiens_hsa003800.55275890
76mTOR signaling pathway_Homo sapiens_hsa041500.55117648
77Linoleic acid metabolism_Homo sapiens_hsa005910.54770538
78Sphingolipid metabolism_Homo sapiens_hsa006000.53270387
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52891400
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52435110
81Dorso-ventral axis formation_Homo sapiens_hsa043200.51360552
82Glutamatergic synapse_Homo sapiens_hsa047240.50740587
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50133065
84Inositol phosphate metabolism_Homo sapiens_hsa005620.47822070
85Alcoholism_Homo sapiens_hsa050340.47632391
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47538607
87Starch and sucrose metabolism_Homo sapiens_hsa005000.46995194
88Gastric acid secretion_Homo sapiens_hsa049710.46944254
89Protein digestion and absorption_Homo sapiens_hsa049740.46245779
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46059211
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45416286
92Fat digestion and absorption_Homo sapiens_hsa049750.44749343
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43971127
94Long-term depression_Homo sapiens_hsa047300.39877665
95Butanoate metabolism_Homo sapiens_hsa006500.39700528
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38535584
97Alzheimers disease_Homo sapiens_hsa050100.37960514
98AMPK signaling pathway_Homo sapiens_hsa041520.37598027
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.37560375
100Lysine degradation_Homo sapiens_hsa003100.35693074
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34053554
102Gap junction_Homo sapiens_hsa045400.33739395
103Dilated cardiomyopathy_Homo sapiens_hsa054140.33403496
104Melanogenesis_Homo sapiens_hsa049160.32986680
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32885417
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32448007
107GnRH signaling pathway_Homo sapiens_hsa049120.30620853
108Ovarian steroidogenesis_Homo sapiens_hsa049130.29430006
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29049569
110Thyroid cancer_Homo sapiens_hsa052160.28427436
111Salivary secretion_Homo sapiens_hsa049700.28023122
112Oocyte meiosis_Homo sapiens_hsa041140.27502515
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.26706931
114Oxytocin signaling pathway_Homo sapiens_hsa049210.25404239
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24376261
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24101268
117Bladder cancer_Homo sapiens_hsa052190.23719466
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22996993
119* ABC transporters_Homo sapiens_hsa020100.22513241
120Calcium signaling pathway_Homo sapiens_hsa040200.21317461
121Phenylalanine metabolism_Homo sapiens_hsa003600.20941807
122Prostate cancer_Homo sapiens_hsa052150.20135646
123Antigen processing and presentation_Homo sapiens_hsa046120.19857043
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19407716
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18752026
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.17960825
127Endometrial cancer_Homo sapiens_hsa052130.16638655
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16428438

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