ABCC6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52579874
2L-phenylalanine catabolic process (GO:0006559)7.52579874
3L-phenylalanine metabolic process (GO:0006558)7.31673757
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31673757
5regulation of cholesterol esterification (GO:0010872)5.19035822
6regulation of fibrinolysis (GO:0051917)5.13066349
7negative regulation of fibrinolysis (GO:0051918)4.98191548
8regulation of protein activation cascade (GO:2000257)4.86519695
9peptidyl-glutamic acid carboxylation (GO:0017187)4.68923218
10protein carboxylation (GO:0018214)4.68923218
11very-low-density lipoprotein particle assembly (GO:0034379)4.64838222
12glyoxylate metabolic process (GO:0046487)4.55394227
13regulation of complement activation (GO:0030449)4.53568847
14aromatic amino acid family catabolic process (GO:0009074)4.39384021
15plasma lipoprotein particle assembly (GO:0034377)4.35573546
16high-density lipoprotein particle remodeling (GO:0034375)4.34575755
17negative regulation of protein activation cascade (GO:2000258)4.15175647
18growth hormone secretion (GO:0030252)4.08001513
19reverse cholesterol transport (GO:0043691)4.06791068
20plasma lipoprotein particle remodeling (GO:0034369)4.05842845
21protein-lipid complex remodeling (GO:0034368)4.05842845
22macromolecular complex remodeling (GO:0034367)4.05842845
23phospholipid efflux (GO:0033700)4.03705386
24cholesterol efflux (GO:0033344)3.99128304
25adult feeding behavior (GO:0008343)3.88332178
26negative regulation of sterol transport (GO:0032372)3.85910403
27negative regulation of cholesterol transport (GO:0032375)3.85910403
28phenylpropanoid metabolic process (GO:0009698)3.85803760
29blood coagulation, intrinsic pathway (GO:0007597)3.85422510
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.82838478
31amino-acid betaine metabolic process (GO:0006577)3.79159672
32sphingosine metabolic process (GO:0006670)3.67189271
33fibrinolysis (GO:0042730)3.67093606
34serine family amino acid catabolic process (GO:0009071)3.63404792
35acylglycerol homeostasis (GO:0055090)3.61255446
36triglyceride homeostasis (GO:0070328)3.61255446
37protein-lipid complex assembly (GO:0065005)3.60995616
38negative regulation of complement activation (GO:0045916)3.59619259
39plasma lipoprotein particle clearance (GO:0034381)3.50953709
40epoxygenase P450 pathway (GO:0019373)3.49226747
41positive regulation of growth hormone secretion (GO:0060124)3.45065780
42aldehyde catabolic process (GO:0046185)3.44670852
43low-density lipoprotein particle remodeling (GO:0034374)3.43804828
44intestinal cholesterol absorption (GO:0030299)3.42032641
45xenobiotic catabolic process (GO:0042178)3.40518328
46diol metabolic process (GO:0034311)3.34910857
47plasma lipoprotein particle organization (GO:0071827)3.34887425
48cellular glucuronidation (GO:0052695)3.34756091
49endocrine hormone secretion (GO:0060986)3.33026569
50sphingoid metabolic process (GO:0046519)3.32625788
51drug catabolic process (GO:0042737)3.31485915
52cellular ketone body metabolic process (GO:0046950)3.27979877
53regulation of plasminogen activation (GO:0010755)3.27740518
54regulation of glucocorticoid secretion (GO:2000849)3.26316834
55glucuronate metabolic process (GO:0019585)3.25632938
56uronic acid metabolic process (GO:0006063)3.25632938
57positive regulation of lipoprotein lipase activity (GO:0051006)3.23841403
58positive regulation of triglyceride lipase activity (GO:0061365)3.23841403
59embryonic retina morphogenesis in camera-type eye (GO:0060059)3.22437447
60heme transport (GO:0015886)3.19992073
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17546596
62drug metabolic process (GO:0017144)3.17365127
63polyketide metabolic process (GO:0030638)3.13806238
64doxorubicin metabolic process (GO:0044598)3.13806238
65daunorubicin metabolic process (GO:0044597)3.13806238
66bile acid metabolic process (GO:0008206)3.13492740
67aminoglycoside antibiotic metabolic process (GO:0030647)3.09186013
68cholesterol homeostasis (GO:0042632)3.08644184
69positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.08065030
70negative regulation of interleukin-1 beta production (GO:0032691)3.07617197
71regulation of triglyceride catabolic process (GO:0010896)3.07539751
72response to mercury ion (GO:0046689)3.04654573
73complement activation, alternative pathway (GO:0006957)3.03005962
74negative regulation of lipase activity (GO:0060192)3.02154985
75regulation of bile acid biosynthetic process (GO:0070857)3.02136618
76negative regulation of blood coagulation (GO:0030195)3.02127921
77negative regulation of hemostasis (GO:1900047)3.02127921
78sterol homeostasis (GO:0055092)3.01557208
79glycine metabolic process (GO:0006544)3.01205987
80alpha-amino acid catabolic process (GO:1901606)3.01034095
81protein-lipid complex subunit organization (GO:0071825)3.00310743
82bile acid biosynthetic process (GO:0006699)3.00032292
83proline metabolic process (GO:0006560)2.98060370
84flavonoid metabolic process (GO:0009812)2.94252622
85aromatic amino acid family metabolic process (GO:0009072)2.91866041
86tyrosine metabolic process (GO:0006570)2.90626929
87negative regulation of coagulation (GO:0050819)2.87918712
88vitamin transmembrane transport (GO:0035461)2.85247431
89ketone body metabolic process (GO:1902224)2.82456899
90regulation of protein glycosylation (GO:0060049)2.82052114
91negative regulation of humoral immune response (GO:0002921)2.81368675
92regulation of apoptotic cell clearance (GO:2000425)2.79177862
93response to nitrosative stress (GO:0051409)2.77288996
94cellular amino acid catabolic process (GO:0009063)2.73817060
95primary alcohol catabolic process (GO:0034310)2.73304822
96L-ascorbic acid metabolic process (GO:0019852)2.73113783
97negative regulation of wound healing (GO:0061045)2.71875346
98serine family amino acid metabolic process (GO:0009069)2.71311519
99nodal signaling pathway (GO:0038092)2.71308544
100phospholipid homeostasis (GO:0055091)2.70255959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.66729412
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.37923189
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.23463985
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.84019793
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.17191689
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.16854842
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.07046646
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93579561
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24017445
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18745443
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18215255
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.15124193
13IGF1R_20145208_ChIP-Seq_DFB_Human2.09983856
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.04706677
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98153290
16GATA4_25053715_ChIP-Seq_YYC3_Human1.93001493
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91363843
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83216468
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78027258
20FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.69894218
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57990224
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57314097
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.54339911
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.53583002
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.46347088
26ER_23166858_ChIP-Seq_MCF-7_Human1.43552549
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41073926
28VDR_22108803_ChIP-Seq_LS180_Human1.37597790
29HTT_18923047_ChIP-ChIP_STHdh_Human1.37335947
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33771481
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28489791
32AR_21909140_ChIP-Seq_LNCAP_Human1.27551047
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23568921
34NANOG_19829295_ChIP-Seq_ESCs_Human1.23099573
35SOX2_19829295_ChIP-Seq_ESCs_Human1.23099573
36ZNF274_21170338_ChIP-Seq_K562_Hela1.22750897
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21556195
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.20917054
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18042609
40TCF4_22108803_ChIP-Seq_LS180_Human1.17939380
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15429216
42SOX2_20726797_ChIP-Seq_SW620_Human1.13939005
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.13918666
44P300_19829295_ChIP-Seq_ESCs_Human1.12623490
45FOXA1_25552417_ChIP-Seq_VCAP_Human1.12439104
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10163162
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.10163162
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08611917
49AR_20517297_ChIP-Seq_VCAP_Human1.08440082
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08206464
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07858089
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07483265
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07293601
54HOXB7_26014856_ChIP-Seq_BT474_Human1.07118200
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06224848
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.05827094
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05767254
58GATA6_25053715_ChIP-Seq_YYC3_Human1.05620281
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04978319
60AR_21572438_ChIP-Seq_LNCaP_Human1.04325225
61CDX2_22108803_ChIP-Seq_LS180_Human1.04289978
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04063822
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02885799
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02866538
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02193405
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00478877
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99558074
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99511894
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98631364
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97818927
71TAF15_26573619_Chip-Seq_HEK293_Human0.96569428
72FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96432364
73* OCT4_20526341_ChIP-Seq_ESCs_Human0.94094946
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.92805029
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.92151413
76BCAT_22108803_ChIP-Seq_LS180_Human0.91754976
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91460929
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91294784
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90500899
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90376298
81EOMES_21245162_ChIP-Seq_HESCs_Human0.90172851
82FUS_26573619_Chip-Seq_HEK293_Human0.89938454
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.89783032
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.89170837
85NCOR_22424771_ChIP-Seq_293T_Human0.88902246
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.88899956
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88643959
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87146383
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.87124337
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87007468
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86267571
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86205207
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86103199
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85921612
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85811097
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.84394984
97CJUN_26792858_Chip-Seq_BT549_Human0.84235837
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.83531629
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83280647
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.82973733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.93551025
2MP0002139_abnormal_hepatobiliary_system5.43038600
3MP0005365_abnormal_bile_salt4.76481058
4MP0005085_abnormal_gallbladder_physiolo4.20891456
5MP0002837_dystrophic_cardiac_calcinosis3.53186903
6MP0005360_urolithiasis3.18346137
7MP0010329_abnormal_lipoprotein_level3.07262970
8MP0002138_abnormal_hepatobiliary_system3.06833482
9MP0008875_abnormal_xenobiotic_pharmacok3.06001969
10MP0002876_abnormal_thyroid_physiology2.97642664
11MP0003252_abnormal_bile_duct2.92643945
12MP0003136_yellow_coat_color2.85489859
13MP0001666_abnormal_nutrient_absorption2.44808685
14MP0003122_maternal_imprinting2.39445783
15MP0003890_abnormal_embryonic-extraembry2.29187318
16MP0002938_white_spotting2.10923135
17MP0005332_abnormal_amino_acid2.06596472
18MP0009840_abnormal_foam_cell2.03329120
19MP0002653_abnormal_ependyma_morphology1.95823463
20MP0009697_abnormal_copulation1.91928901
21MP0000566_synostosis1.90018729
22MP0004019_abnormal_vitamin_homeostasis1.87699315
23MP0004043_abnormal_pH_regulation1.87687747
24MP0003868_abnormal_feces_composition1.85362215
25MP0005670_abnormal_white_adipose1.84558693
26MP0005408_hypopigmentation1.80914028
27MP0003011_delayed_dark_adaptation1.80323610
28MP0002168_other_aberrant_phenotype1.55892697
29MP0002118_abnormal_lipid_homeostasis1.47004660
30MP0005220_abnormal_exocrine_pancreas1.40409832
31MP0003879_abnormal_hair_cell1.39922592
32MP0001764_abnormal_homeostasis1.39381190
33MP0002909_abnormal_adrenal_gland1.32895430
34MP0005636_abnormal_mineral_homeostasis1.31877429
35MP0001756_abnormal_urination1.29254213
36MP0003186_abnormal_redox_activity1.29195896
37MP0005395_other_phenotype1.27925502
38MP0003123_paternal_imprinting1.22252131
39MP0010368_abnormal_lymphatic_system1.22141928
40MP0006072_abnormal_retinal_apoptosis1.18888911
41MP0001984_abnormal_olfaction1.18871345
42MP0004133_heterotaxia1.15988788
43MP0000609_abnormal_liver_physiology1.13774356
44MP0006054_spinal_hemorrhage1.13016737
45MP0009643_abnormal_urine_homeostasis1.11639774
46MP0003045_fibrosis1.09406601
47MP0002160_abnormal_reproductive_system1.07537306
48MP0005551_abnormal_eye_electrophysiolog1.05585143
49MP0001944_abnormal_pancreas_morphology1.04895503
50MP0005266_abnormal_metabolism1.04440121
51MP0006036_abnormal_mitochondrial_physio1.01883042
52MP0005379_endocrine/exocrine_gland_phen0.97189507
53MP0002078_abnormal_glucose_homeostasis0.96912194
54MP0005319_abnormal_enzyme/_coenzyme0.95596534
55MP0002132_abnormal_respiratory_system0.95052197
56MP0005171_absent_coat_pigmentation0.93090443
57MP0010386_abnormal_urinary_bladder0.90889282
58MP0001661_extended_life_span0.90807867
59MP0004272_abnormal_basement_membrane0.90649853
60MP0005187_abnormal_penis_morphology0.90043880
61MP0002254_reproductive_system_inflammat0.88842886
62MP0003953_abnormal_hormone_level0.87577694
63MP0005376_homeostasis/metabolism_phenot0.86556800
64MP0003183_abnormal_peptide_metabolism0.80619701
65MP0009780_abnormal_chondrocyte_physiolo0.80272463
66MP0005248_abnormal_Harderian_gland0.77442553
67MP0003121_genomic_imprinting0.77381251
68MP0001324_abnormal_eye_pigmentation0.74788237
69MP0009642_abnormal_blood_homeostasis0.74160186
70MP0005448_abnormal_energy_balance0.73832226
71MP0002971_abnormal_brown_adipose0.73518395
72MP0001346_abnormal_lacrimal_gland0.72888475
73MP0003718_maternal_effect0.71587443
74MP0003646_muscle_fatigue0.70313165
75MP0000639_abnormal_adrenal_gland0.67581733
76MP0005058_abnormal_lysosome_morphology0.65650136
77MP0005646_abnormal_pituitary_gland0.64943696
78MP0005377_hearing/vestibular/ear_phenot0.63819148
79MP0003878_abnormal_ear_physiology0.63819148
80MP0000598_abnormal_liver_morphology0.63680083
81MP0003943_abnormal_hepatobiliary_system0.62923189
82MP0005084_abnormal_gallbladder_morpholo0.61835808
83MP0003941_abnormal_skin_development0.61581222
84MP0002693_abnormal_pancreas_physiology0.60858556
85MP0000647_abnormal_sebaceous_gland0.60446794
86MP0001915_intracranial_hemorrhage0.59906007
87MP0005389_reproductive_system_phenotype0.58651716
88MP0002928_abnormal_bile_duct0.58217878
89MP0003806_abnormal_nucleotide_metabolis0.56396123
90MP0005410_abnormal_fertilization0.56239778
91MP0010352_gastrointestinal_tract_polyps0.55921277
92MP0005584_abnormal_enzyme/coenzyme_acti0.55148141
93MP0005253_abnormal_eye_physiology0.53208251
94MP0005330_cardiomyopathy0.52764341
95MP0003950_abnormal_plasma_membrane0.51064595
96MP0003638_abnormal_response/metabolism_0.48531785
97MP0005452_abnormal_adipose_tissue0.48504705
98MP0000653_abnormal_sex_gland0.47381297
99MP0006035_abnormal_mitochondrial_morpho0.46382679
100MP0009115_abnormal_fat_cell0.44638429

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44489552
2Deep venous thrombosis (HP:0002625)6.55667472
3Hypobetalipoproteinemia (HP:0003563)5.89182772
4Prolonged partial thromboplastin time (HP:0003645)5.77793489
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.79461653
6Hypolipoproteinemia (HP:0010981)4.19036512
7Xanthomatosis (HP:0000991)4.01889542
8Acanthocytosis (HP:0001927)4.01656606
9Fat malabsorption (HP:0002630)3.69350815
10Joint hemorrhage (HP:0005261)3.68761907
11Intrahepatic cholestasis (HP:0001406)3.47915050
12Abnormality of the common coagulation pathway (HP:0010990)3.41422912
13Steatorrhea (HP:0002570)3.41232332
14Complement deficiency (HP:0004431)3.37029203
15Hyperglycinemia (HP:0002154)3.33058554
16Glomerulonephritis (HP:0000099)3.22079201
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09227832
18Spontaneous abortion (HP:0005268)3.08737557
19Vascular calcification (HP:0004934)3.06799590
20Hypoalphalipoproteinemia (HP:0003233)3.04828000
21Amelogenesis imperfecta (HP:0000705)2.94889498
22Epidermoid cyst (HP:0200040)2.93611724
23Pancreatic islet-cell hyperplasia (HP:0004510)2.91990846
24Abnormality of urine glucose concentration (HP:0011016)2.78910104
25Glycosuria (HP:0003076)2.78910104
26Double outlet right ventricle (HP:0001719)2.71284166
27Congenital malformation of the right heart (HP:0011723)2.71284166
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.67494727
29Pigmentary retinal degeneration (HP:0001146)2.63429743
30Enlarged kidneys (HP:0000105)2.55458090
31Cardiovascular calcification (HP:0011915)2.54810863
32Hypomagnesemia (HP:0002917)2.53512810
33Potter facies (HP:0002009)2.52476431
34Facial shape deformation (HP:0011334)2.52476431
35Reduced antithrombin III activity (HP:0001976)2.51571698
36Abnormality of glycine metabolism (HP:0010895)2.50427547
37Abnormality of serine family amino acid metabolism (HP:0010894)2.50427547
38Increased circulating renin level (HP:0000848)2.43528798
39Generalized aminoaciduria (HP:0002909)2.41267524
40Hypoglycemic coma (HP:0001325)2.40385648
41Type I transferrin isoform profile (HP:0003642)2.40140772
42Pancreatic cysts (HP:0001737)2.37859214
43Gout (HP:0001997)2.36914830
44Increased serum pyruvate (HP:0003542)2.36711740
45Retinal atrophy (HP:0001105)2.35867729
46Abnormal respiratory motile cilium physiology (HP:0012261)2.33136141
47Rhinitis (HP:0012384)2.30655185
48Hyperphosphaturia (HP:0003109)2.27483004
49Abnormality of complement system (HP:0005339)2.25625868
50Abnormality of glycolysis (HP:0004366)2.25393831
51Hyperactive renin-angiotensin system (HP:0000841)2.25031354
52Abnormal respiratory motile cilium morphology (HP:0005938)2.24158536
53Abnormal respiratory epithelium morphology (HP:0012253)2.24158536
54Abnormality of pyrimidine metabolism (HP:0004353)2.22427610
55Systemic lupus erythematosus (HP:0002725)2.21651046
56Proximal tubulopathy (HP:0000114)2.21041429
57Parakeratosis (HP:0001036)2.20115858
58Arthropathy (HP:0003040)2.20092389
59Hypercholesterolemia (HP:0003124)2.19800314
60Abnormal ciliary motility (HP:0012262)2.19129788
61Abnormality of magnesium homeostasis (HP:0004921)2.18931984
62Hyperglycinuria (HP:0003108)2.15542202
63Hyperlipoproteinemia (HP:0010980)2.14459112
64Broad alveolar ridges (HP:0000187)2.13822129
65Hyperammonemia (HP:0001987)2.13158492
66Chronic hepatic failure (HP:0100626)2.10300340
67Abnormality of vitamin metabolism (HP:0100508)2.09907107
68Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08243098
69Delayed CNS myelination (HP:0002188)2.08167794
70Conjugated hyperbilirubinemia (HP:0002908)2.00924256
71Abnormality of the intrinsic pathway (HP:0010989)2.00296398
72Abnormality of serum amino acid levels (HP:0003112)1.99565200
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99502919
74Abnormal protein N-linked glycosylation (HP:0012347)1.99502919
75Abnormal protein glycosylation (HP:0012346)1.99502919
76Abnormal glycosylation (HP:0012345)1.99502919
77Hypothermia (HP:0002045)1.98402890
78Abnormal tarsal ossification (HP:0008369)1.97998516
79Acute encephalopathy (HP:0006846)1.93773445
80True hermaphroditism (HP:0010459)1.90237227
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89572904
82Opisthotonus (HP:0002179)1.87740820
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.86504182
84Absent/shortened dynein arms (HP:0200106)1.86504182
85Abnormality of methionine metabolism (HP:0010901)1.85718402
86Beaking of vertebral bodies (HP:0004568)1.85492711
87Metabolic acidosis (HP:0001942)1.84910977
88Abnormality of nucleobase metabolism (HP:0010932)1.84843369
89Abnormality of fatty-acid metabolism (HP:0004359)1.84628119
90Menorrhagia (HP:0000132)1.81098691
91Abnormal urine output (HP:0012590)1.80622272
92Vacuolated lymphocytes (HP:0001922)1.80368866
93Hypophosphatemic rickets (HP:0004912)1.80190519
94Renal salt wasting (HP:0000127)1.78381727
95Hepatocellular carcinoma (HP:0001402)1.78378449
96Rickets (HP:0002748)1.77167246
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76584081
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75904805
99Hypotension (HP:0002615)1.75591696
100Pancreatic fibrosis (HP:0100732)1.75198484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.02055620
2STK38L5.34465409
3LATS23.74581632
4WNK33.02547080
5NLK2.64307588
6BUB12.63843240
7NEK12.53004009
8EPHA32.37698972
9FGFR42.25741564
10FRK2.01277974
11FER1.90194686
12STK31.88834107
13OXSR11.78971496
14EPHA21.78415695
15MAP3K41.75263266
16PBK1.74576173
17MST41.66793647
18ACVR1B1.64395474
19STK381.63904300
20ZAK1.62008216
21STK241.61054180
22WNK41.57603227
23PRKD31.51838094
24MAP3K121.49653612
25VRK21.47852202
26BRSK21.42906799
27MAP3K91.38831662
28MAP3K21.33457197
29TTK1.29389236
30CDK191.22517144
31GRK11.19324178
32EIF2AK31.19179591
33BMPR1B1.15051176
34STK391.07142808
35MUSK1.05280844
36WEE11.04615610
37NEK21.02353347
38NME11.00977737
39EIF2AK11.00939371
40CSNK1A1L1.00298590
41PRKAA20.99572212
42FGFR30.99017081
43FLT30.93676340
44CASK0.90139733
45FGFR10.88071535
46MYLK0.87007121
47BCKDK0.86696501
48PDK20.86428969
49IRAK10.85925763
50PKN20.82240135
51PLK20.77613028
52PAK40.76839308
53MAPKAPK30.76756810
54MELK0.75941131
55PRKCE0.69586642
56PLK30.69379151
57ADRBK20.68783434
58PLK10.68601803
59CSNK1G10.67943047
60PRKCG0.64911436
61STK40.64726107
62PHKG10.62381616
63PHKG20.62381616
64INSRR0.61830405
65MKNK20.60189476
66CAMK2D0.58527635
67CCNB10.55176469
68PIK3CG0.53556526
69IRAK30.52211470
70LIMK10.50059018
71TGFBR20.49787787
72BRSK10.46967692
73MST1R0.45938986
74DAPK10.45792730
75CSNK1G30.44802129
76PIK3CA0.43571555
77PDPK10.42424406
78MAPK150.41941219
79ABL20.40605278
80PTK20.40325141
81CSNK1G20.39377195
82AKT20.38445975
83MKNK10.37827016
84FGFR20.37658132
85PRKACB0.35913111
86MAP2K20.34974364
87MET0.33628173
88NEK90.32575718
89ERBB30.32496275
90CSNK1A10.32172620
91SRPK10.31732252
92AURKB0.31250914
93ERBB20.28287509
94MAPK110.27691624
95PAK30.27262806
96CSNK2A10.26946299
97DYRK20.25735326
98MAP2K70.25561635
99GRK70.24686387
100PRKACA0.22421128

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55261584
2Complement and coagulation cascades_Homo sapiens_hsa046102.86962235
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82006616
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68056483
5Phenylalanine metabolism_Homo sapiens_hsa003602.55208264
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.49346953
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.43924758
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28880714
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22724576
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18636461
11Butanoate metabolism_Homo sapiens_hsa006502.14827081
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13533349
13Fatty acid degradation_Homo sapiens_hsa000712.04642163
14Histidine metabolism_Homo sapiens_hsa003402.02157039
15Chemical carcinogenesis_Homo sapiens_hsa052042.01081217
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00023771
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89953853
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.86866800
19Retinol metabolism_Homo sapiens_hsa008301.84708961
20Propanoate metabolism_Homo sapiens_hsa006401.82884858
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79430397
22Arginine biosynthesis_Homo sapiens_hsa002201.78936429
23Peroxisome_Homo sapiens_hsa041461.73851069
24Fatty acid elongation_Homo sapiens_hsa000621.72581369
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.70824742
26beta-Alanine metabolism_Homo sapiens_hsa004101.70009782
27Tryptophan metabolism_Homo sapiens_hsa003801.64632149
28Fat digestion and absorption_Homo sapiens_hsa049751.62475734
29Pyruvate metabolism_Homo sapiens_hsa006201.61237918
30Tyrosine metabolism_Homo sapiens_hsa003501.59257829
31Fatty acid metabolism_Homo sapiens_hsa012121.46105828
32Vitamin digestion and absorption_Homo sapiens_hsa049771.39976216
33Arginine and proline metabolism_Homo sapiens_hsa003301.38539108
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38435290
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37510691
36Glutathione metabolism_Homo sapiens_hsa004801.36148095
37PPAR signaling pathway_Homo sapiens_hsa033201.35896545
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.35765760
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33866776
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.30266219
41Sulfur metabolism_Homo sapiens_hsa009201.28352982
42Sphingolipid metabolism_Homo sapiens_hsa006001.26468984
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25251969
44Starch and sucrose metabolism_Homo sapiens_hsa005001.22565250
45Folate biosynthesis_Homo sapiens_hsa007901.22132164
46Vitamin B6 metabolism_Homo sapiens_hsa007501.21641963
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16428695
48N-Glycan biosynthesis_Homo sapiens_hsa005101.10033378
49Steroid biosynthesis_Homo sapiens_hsa001001.06794669
50Biosynthesis of amino acids_Homo sapiens_hsa012301.06606229
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04071910
52Bile secretion_Homo sapiens_hsa049761.02602205
53Carbon metabolism_Homo sapiens_hsa012001.00190680
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99126563
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98039637
56Oxidative phosphorylation_Homo sapiens_hsa001900.97254396
57Caffeine metabolism_Homo sapiens_hsa002320.93795655
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.93723886
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89937936
60Protein export_Homo sapiens_hsa030600.89578615
61Other glycan degradation_Homo sapiens_hsa005110.85794287
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.81117594
63Proteasome_Homo sapiens_hsa030500.80117975
64Metabolic pathways_Homo sapiens_hsa011000.79538652
65Galactose metabolism_Homo sapiens_hsa000520.77976730
66Linoleic acid metabolism_Homo sapiens_hsa005910.75277730
67Sulfur relay system_Homo sapiens_hsa041220.73242814
68Nitrogen metabolism_Homo sapiens_hsa009100.69319554
69Glycerolipid metabolism_Homo sapiens_hsa005610.67538202
70One carbon pool by folate_Homo sapiens_hsa006700.65983193
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65600935
72Arachidonic acid metabolism_Homo sapiens_hsa005900.65349974
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65301133
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63638130
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60813684
76Parkinsons disease_Homo sapiens_hsa050120.58425360
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57947239
78Huntingtons disease_Homo sapiens_hsa050160.53810892
79Lysine degradation_Homo sapiens_hsa003100.52233144
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47243948
81Fatty acid biosynthesis_Homo sapiens_hsa000610.47164824
82Phototransduction_Homo sapiens_hsa047440.43928286
83ABC transporters_Homo sapiens_hsa020100.43641147
84Selenocompound metabolism_Homo sapiens_hsa004500.42464575
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40591969
86Renin-angiotensin system_Homo sapiens_hsa046140.39403349
87Mismatch repair_Homo sapiens_hsa034300.34277897
88RNA polymerase_Homo sapiens_hsa030200.33948383
89Alzheimers disease_Homo sapiens_hsa050100.33767968
90Mineral absorption_Homo sapiens_hsa049780.33602309
91Fructose and mannose metabolism_Homo sapiens_hsa000510.33232948
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28230155
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21534911
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19082604
95Adherens junction_Homo sapiens_hsa045200.14933520
96Thyroid hormone synthesis_Homo sapiens_hsa049180.14726671
97Pentose phosphate pathway_Homo sapiens_hsa000300.13358028
98Collecting duct acid secretion_Homo sapiens_hsa049660.12657934
99Fanconi anemia pathway_Homo sapiens_hsa034600.12333875
100Taste transduction_Homo sapiens_hsa047420.12056373

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »