ABCC6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)7.93191990
2regulation of fibrinolysis (GO:0051917)7.57128963
3very-low-density lipoprotein particle assembly (GO:0034379)6.66031293
4protein carboxylation (GO:0018214)6.54297607
5peptidyl-glutamic acid carboxylation (GO:0017187)6.54297607
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.44574322
7L-phenylalanine catabolic process (GO:0006559)6.44574322
8regulation of protein activation cascade (GO:2000257)6.40750700
9plasma lipoprotein particle assembly (GO:0034377)6.27213331
10cholesterol efflux (GO:0033344)6.13120286
11regulation of complement activation (GO:0030449)6.09308951
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.06656844
13L-phenylalanine metabolic process (GO:0006558)6.06656844
14intestinal cholesterol absorption (GO:0030299)5.77924419
15negative regulation of sterol transport (GO:0032372)5.76509462
16negative regulation of cholesterol transport (GO:0032375)5.76509462
17regulation of cholesterol esterification (GO:0010872)5.67932853
18high-density lipoprotein particle remodeling (GO:0034375)5.56309233
19plasma lipoprotein particle remodeling (GO:0034369)5.54598625
20protein-lipid complex remodeling (GO:0034368)5.54598625
21macromolecular complex remodeling (GO:0034367)5.54598625
22blood coagulation, intrinsic pathway (GO:0007597)5.49834365
23protein-lipid complex assembly (GO:0065005)5.47088008
24complement activation, alternative pathway (GO:0006957)5.31284789
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30669245
26exogenous drug catabolic process (GO:0042738)5.25820737
27phospholipid efflux (GO:0033700)5.11527440
28epoxygenase P450 pathway (GO:0019373)5.04401662
29fibrinolysis (GO:0042730)5.01557416
30reverse cholesterol transport (GO:0043691)5.00720482
31regulation of plasminogen activation (GO:0010755)4.91451862
32drug catabolic process (GO:0042737)4.89339566
33plasma lipoprotein particle organization (GO:0071827)4.87781951
34low-density lipoprotein particle remodeling (GO:0034374)4.77243192
35negative regulation of lipase activity (GO:0060192)4.71238605
36plasma lipoprotein particle clearance (GO:0034381)4.53859964
37protein-lipid complex subunit organization (GO:0071825)4.52527616
38glyoxylate metabolic process (GO:0046487)4.52266790
39cellular glucuronidation (GO:0052695)4.37587261
40ethanol oxidation (GO:0006069)4.34102509
41acylglycerol homeostasis (GO:0055090)4.29046443
42triglyceride homeostasis (GO:0070328)4.29046443
43aromatic amino acid family catabolic process (GO:0009074)4.23601184
44negative regulation of blood coagulation (GO:0030195)4.21885592
45negative regulation of hemostasis (GO:1900047)4.21885592
46positive regulation of lipoprotein lipase activity (GO:0051006)4.20599753
47positive regulation of triglyceride lipase activity (GO:0061365)4.20599753
48intestinal absorption (GO:0050892)4.19270562
49regulation of triglyceride catabolic process (GO:0010896)4.16769940
50regulation of bile acid biosynthetic process (GO:0070857)4.16142435
51omega-hydroxylase P450 pathway (GO:0097267)4.13105229
52regulation of apoptotic cell clearance (GO:2000425)4.12585379
53glucuronate metabolic process (GO:0019585)4.11588891
54uronic acid metabolic process (GO:0006063)4.11588891
55urea metabolic process (GO:0019627)4.10859486
56bile acid metabolic process (GO:0008206)4.08756740
57negative regulation of digestive system process (GO:0060457)4.07863217
58regulation of humoral immune response (GO:0002920)4.06845801
59regulation of DNA methylation (GO:0044030)3.99833794
60regulation of female gonad development (GO:2000194)3.97416945
61cholesterol homeostasis (GO:0042632)3.92360707
62sterol homeostasis (GO:0055092)3.87027788
63cholesterol transport (GO:0030301)3.81759972
64sterol transport (GO:0015918)3.81759972
65negative regulation of coagulation (GO:0050819)3.81566143
66protein activation cascade (GO:0072376)3.78879008
67negative regulation of protein activation cascade (GO:2000258)3.77728182
68regulation of acrosome reaction (GO:0060046)3.77664579
69positive regulation of hemostasis (GO:1900048)3.74804007
70positive regulation of blood coagulation (GO:0030194)3.74804007
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.74570300
72oxidative demethylation (GO:0070989)3.73941911
73nitrogen cycle metabolic process (GO:0071941)3.65724813
74imidazole-containing compound metabolic process (GO:0052803)3.65639463
75serine family amino acid catabolic process (GO:0009071)3.65464187
76negative regulation of wound healing (GO:0061045)3.63458852
77urea cycle (GO:0000050)3.62392772
78positive regulation of fatty acid biosynthetic process (GO:0045723)3.57802428
79drug metabolic process (GO:0017144)3.55600385
80glutamate metabolic process (GO:0006536)3.54241090
81lipoprotein metabolic process (GO:0042157)3.51023672
82positive regulation of coagulation (GO:0050820)3.48587098
83drinking behavior (GO:0042756)3.48471187
84positive regulation of steroid metabolic process (GO:0045940)3.48350483
85acute-phase response (GO:0006953)3.47564226
86ethanol metabolic process (GO:0006067)3.45558395
87bile acid biosynthetic process (GO:0006699)3.44452144
88positive regulation of cellular amine metabolic process (GO:0033240)3.42716599
89drug transmembrane transport (GO:0006855)3.36850570
90regulation of lipoprotein particle clearance (GO:0010984)3.36138145
91regulation of cholesterol homeostasis (GO:2000188)3.35154130
92complement activation, classical pathway (GO:0006958)3.34726903
93glycine metabolic process (GO:0006544)3.34464456
94fat-soluble vitamin biosynthetic process (GO:0042362)3.30775170
95tyrosine metabolic process (GO:0006570)3.30303740
96bile acid and bile salt transport (GO:0015721)3.25495647
97regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.23974125
98piRNA metabolic process (GO:0034587)3.16825232
99lipid homeostasis (GO:0055088)3.14032381
100regulation of meiosis I (GO:0060631)3.10548545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.57712258
2EZH2_22144423_ChIP-Seq_EOC_Human6.47589236
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.26273082
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.66228870
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.60395828
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12511680
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.09639846
8PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01564421
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.64224743
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.49023392
11FOXA2_19822575_ChIP-Seq_HepG2_Human3.35397692
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.31727141
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22407802
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.94143012
15HNF4A_19822575_ChIP-Seq_HepG2_Human2.92281619
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.85304210
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84853472
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84499491
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.67973298
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33879045
21AR_21909140_ChIP-Seq_LNCAP_Human2.26295870
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87950967
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86870320
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78336634
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78336634
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78336634
27GATA4_25053715_ChIP-Seq_YYC3_Human1.69209484
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62686873
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56345326
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.53193820
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48030547
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37814582
33HTT_18923047_ChIP-ChIP_STHdh_Human1.36649913
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36140556
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30728336
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25811948
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.17850006
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.17042193
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13643728
40GATA6_25053715_ChIP-Seq_YYC3_Human1.08208989
41NANOG_20526341_ChIP-Seq_ESCs_Human1.05609821
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02958350
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02922258
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.00255406
45FOXH1_21741376_ChIP-Seq_EPCs_Human0.98883524
46CBP_21632823_ChIP-Seq_H3396_Human0.97566776
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97117394
48FOXA1_25552417_ChIP-Seq_VCAP_Human0.93491504
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92903152
50SOX2_21211035_ChIP-Seq_LN229_Human0.92216897
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92121914
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90484657
53IRF1_19129219_ChIP-ChIP_H3396_Human0.90412951
54TP53_16413492_ChIP-PET_HCT116_Human0.88338911
55CDX2_20551321_ChIP-Seq_CACO-2_Human0.87616005
56AR_20517297_ChIP-Seq_VCAP_Human0.86728846
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85195260
58FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84951301
59ESR2_21235772_ChIP-Seq_MCF-7_Human0.82369772
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81510511
61SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81493209
62GBX2_23144817_ChIP-Seq_PC3_Human0.80230386
63CEBPB_22108803_ChIP-Seq_LS180_Human0.79722354
64CDX2_22108803_ChIP-Seq_LS180_Human0.78941859
65RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78460663
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77248003
67PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75710655
68STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.74870731
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73379113
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72301860
71TCF4_23295773_ChIP-Seq_U87_Human0.71876680
72GF1_26923725_Chip-Seq_HPCs_Mouse0.71754843
73SMAD4_21741376_ChIP-Seq_EPCs_Human0.70280494
74RAC3_21632823_ChIP-Seq_H3396_Human0.70133240
75CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69762897
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.68068802
77GATA3_24758297_ChIP-Seq_MCF-7_Human0.67879770
78STAT3_23295773_ChIP-Seq_U87_Human0.67344674
79SOX2_19829295_ChIP-Seq_ESCs_Human0.66736239
80NANOG_19829295_ChIP-Seq_ESCs_Human0.66736239
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64979451
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.64181288
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60430441
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.60191913
85OCT4_20526341_ChIP-Seq_ESCs_Human0.60058802
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59413497
87ZNF217_24962896_ChIP-Seq_MCF-7_Human0.59289138
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.59165425
89MYC_19829295_ChIP-Seq_ESCs_Human0.58856291
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56823934
91CBP_20019798_ChIP-Seq_JUKART_Human0.56683129
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.56683129
93AR_25329375_ChIP-Seq_VCAP_Human0.56366511
94RUNX2_22187159_ChIP-Seq_PCA_Human0.56357318
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.54049367
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.54049367
97TAF2_19829295_ChIP-Seq_ESCs_Human0.52134897
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.52054259
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.51522025
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50974326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.45241083
2MP0005360_urolithiasis6.59784033
3MP0005085_abnormal_gallbladder_physiolo4.87094790
4MP0005365_abnormal_bile_salt4.77024085
5MP0003195_calcinosis4.66965567
6MP0003718_maternal_effect4.08411168
7MP0001666_abnormal_nutrient_absorption3.89575295
8MP0008875_abnormal_xenobiotic_pharmacok3.61547110
9MP0009840_abnormal_foam_cell3.39826639
10MP0003252_abnormal_bile_duct3.36763375
11MP0010329_abnormal_lipoprotein_level3.13048068
12MP0002138_abnormal_hepatobiliary_system2.86607937
13MP0003868_abnormal_feces_composition2.66814539
14MP0006292_abnormal_olfactory_placode2.45086325
15MP0000566_synostosis2.38070206
16MP0003122_maternal_imprinting2.26092162
17MP0005395_other_phenotype1.97812044
18MP0003879_abnormal_hair_cell1.80943464
19MP0003890_abnormal_embryonic-extraembry1.80700828
20MP0005332_abnormal_amino_acid1.76342048
21MP0010368_abnormal_lymphatic_system1.73670643
22MP0002118_abnormal_lipid_homeostasis1.54689208
23MP0005408_hypopigmentation1.49434348
24MP0003183_abnormal_peptide_metabolism1.49139713
25MP0008789_abnormal_olfactory_epithelium1.47525131
26MP0004019_abnormal_vitamin_homeostasis1.42888575
27MP0005394_taste/olfaction_phenotype1.40961281
28MP0005499_abnormal_olfactory_system1.40961281
29MP0000609_abnormal_liver_physiology1.32310950
30MP0003699_abnormal_female_reproductive1.27487823
31MP0003950_abnormal_plasma_membrane1.24846006
32MP0009697_abnormal_copulation1.20970922
33MP0002876_abnormal_thyroid_physiology1.16398026
34MP0002132_abnormal_respiratory_system1.15060171
35MP0005410_abnormal_fertilization1.14935413
36MP0002089_abnormal_postnatal_growth/wei1.10296725
37MP0001764_abnormal_homeostasis1.07684431
38MP0003121_genomic_imprinting1.06470120
39MP0003191_abnormal_cellular_cholesterol1.04092036
40MP0005319_abnormal_enzyme/_coenzyme1.02084797
41MP0005646_abnormal_pituitary_gland0.99848335
42MP0010030_abnormal_orbit_morphology0.97183412
43MP0001929_abnormal_gametogenesis0.94246652
44MP0002160_abnormal_reproductive_system0.92899583
45MP0008877_abnormal_DNA_methylation0.91482298
46MP0010234_abnormal_vibrissa_follicle0.90742376
47MP0002234_abnormal_pharynx_morphology0.88306748
48MP0001293_anophthalmia0.86581265
49MP0005451_abnormal_body_composition0.84511460
50MP0001915_intracranial_hemorrhage0.84301396
51MP0002161_abnormal_fertility/fecundity0.82912024
52MP0005647_abnormal_sex_gland0.78865161
53MP0005058_abnormal_lysosome_morphology0.78750144
54MP0005409_darkened_coat_color0.74990904
55MP0005636_abnormal_mineral_homeostasis0.73240296
56MP0000653_abnormal_sex_gland0.73075337
57MP0000598_abnormal_liver_morphology0.71265146
58MP0003123_paternal_imprinting0.71114288
59MP0009780_abnormal_chondrocyte_physiolo0.70096248
60MP0009642_abnormal_blood_homeostasis0.70039250
61MP0003136_yellow_coat_color0.69627604
62MP0001324_abnormal_eye_pigmentation0.69431642
63MP0002210_abnormal_sex_determination0.69054352
64MP0003656_abnormal_erythrocyte_physiolo0.68264092
65MP0003806_abnormal_nucleotide_metabolis0.67436366
66MP0002233_abnormal_nose_morphology0.67164113
67MP0009643_abnormal_urine_homeostasis0.63668989
68MP0005551_abnormal_eye_electrophysiolog0.62458025
69MP0003693_abnormal_embryo_hatching0.61977126
70MP0004043_abnormal_pH_regulation0.58769244
71MP0004142_abnormal_muscle_tone0.54480662
72MP0000639_abnormal_adrenal_gland0.54157416
73MP0001730_embryonic_growth_arrest0.52868211
74MP0001756_abnormal_urination0.51492192
75MP0001119_abnormal_female_reproductive0.50954708
76MP0003698_abnormal_male_reproductive0.50942095
77MP0002078_abnormal_glucose_homeostasis0.49992481
78MP0001986_abnormal_taste_sensitivity0.49744025
79MP0003953_abnormal_hormone_level0.49519828
80MP0001145_abnormal_male_reproductive0.49367778
81MP0003941_abnormal_skin_development0.49314989
82MP0000762_abnormal_tongue_morphology0.48669720
83MP0005376_homeostasis/metabolism_phenot0.47191156
84MP0003119_abnormal_digestive_system0.45614201
85MP0005584_abnormal_enzyme/coenzyme_acti0.45421937
86MP0005389_reproductive_system_phenotype0.43503302
87MP0005084_abnormal_gallbladder_morpholo0.43397300
88MP0000678_abnormal_parathyroid_gland0.43094220
89MP0001984_abnormal_olfaction0.42750645
90MP0002971_abnormal_brown_adipose0.42280489
91MP0001661_extended_life_span0.41240366
92MP0005464_abnormal_platelet_physiology0.40588327
93MP0003567_abnormal_fetal_cardiomyocyte0.39116681
94MP0009115_abnormal_fat_cell0.38661038
95MP0002168_other_aberrant_phenotype0.38284271
96MP0002282_abnormal_trachea_morphology0.37636467
97MP0005334_abnormal_fat_pad0.37227826
98MP0005220_abnormal_exocrine_pancreas0.36745581
99MP0008469_abnormal_protein_level0.36675956
100MP0001944_abnormal_pancreas_morphology0.35879342

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.81483894
2Prolonged partial thromboplastin time (HP:0003645)7.99724551
3Hypobetalipoproteinemia (HP:0003563)7.05181076
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.86718962
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83372902
6Complement deficiency (HP:0004431)6.23320688
7Joint hemorrhage (HP:0005261)5.88147908
8Abnormality of the common coagulation pathway (HP:0010990)4.85518765
9Abnormality of complement system (HP:0005339)4.65344893
10Hypolipoproteinemia (HP:0010981)4.49013739
11Intrahepatic cholestasis (HP:0001406)4.48452121
12Xanthomatosis (HP:0000991)4.42957072
13Spontaneous abortion (HP:0005268)4.34927946
14Hypophosphatemic rickets (HP:0004912)4.32144677
15Osteomalacia (HP:0002749)4.21124132
16Conjugated hyperbilirubinemia (HP:0002908)4.15098311
17Systemic lupus erythematosus (HP:0002725)4.06055844
18Glomerulonephritis (HP:0000099)4.05191474
19Hypercholesterolemia (HP:0003124)3.80482261
20Fat malabsorption (HP:0002630)3.67373526
21Hyperlipoproteinemia (HP:0010980)3.62795706
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55757294
23Generalized aminoaciduria (HP:0002909)3.36670298
24Hyperglycinemia (HP:0002154)3.34974963
25Hemorrhage of the eye (HP:0011885)3.33989645
26Vascular calcification (HP:0004934)3.31143310
27Rickets (HP:0002748)3.25093471
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.19391093
29Abnormal gallbladder physiology (HP:0012438)3.12213408
30Cholecystitis (HP:0001082)3.12213408
31Supernumerary spleens (HP:0009799)3.05440254
32Hypoalphalipoproteinemia (HP:0003233)3.01785728
33Epidermoid cyst (HP:0200040)3.01329858
34Menorrhagia (HP:0000132)2.98283918
35Abnormal tarsal ossification (HP:0008369)2.90922884
36Acanthocytosis (HP:0001927)2.87783961
37Cardiovascular calcification (HP:0011915)2.83100654
38Hypoglycemic coma (HP:0001325)2.76176138
39Steatorrhea (HP:0002570)2.75261333
40Proximal tubulopathy (HP:0000114)2.73474445
41Abnormality of carpal bone ossification (HP:0006257)2.66332372
42Mitral stenosis (HP:0001718)2.60666598
43Abnormality of serine family amino acid metabolism (HP:0010894)2.57764268
44Abnormality of glycine metabolism (HP:0010895)2.57764268
45Abnormality of pyrimidine metabolism (HP:0004353)2.57423321
46Abnormality of the intrinsic pathway (HP:0010989)2.57206499
47Gingival bleeding (HP:0000225)2.55400324
48Broad alveolar ridges (HP:0000187)2.42128565
49Impulsivity (HP:0100710)2.41974701
50Nephritis (HP:0000123)2.38257464
51Fair hair (HP:0002286)2.36224775
52Pigmentary retinal degeneration (HP:0001146)2.31717754
53Flat acetabular roof (HP:0003180)2.31596194
54Azoospermia (HP:0000027)2.29493633
55Malnutrition (HP:0004395)2.27982570
56Purpura (HP:0000979)2.27070215
57Facial hemangioma (HP:0000329)2.25452586
58Bifid scrotum (HP:0000048)2.24628132
59Glycosuria (HP:0003076)2.21549403
60Abnormality of urine glucose concentration (HP:0011016)2.21549403
61Papillary thyroid carcinoma (HP:0002895)2.21303984
62Hyperglycinuria (HP:0003108)2.20314365
63Metaphyseal irregularity (HP:0003025)2.17435327
64Thrombophlebitis (HP:0004418)2.15324552
65Abnormal urine phosphate concentration (HP:0012599)2.14792086
66Hyperammonemia (HP:0001987)2.13276107
67Recurrent gram-negative bacterial infections (HP:0005420)2.12427297
68Prenatal maternal abnormality (HP:0002686)2.11113795
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10047731
70Premature ovarian failure (HP:0008209)2.06931506
71Delayed CNS myelination (HP:0002188)2.06645961
72Abnormality of methionine metabolism (HP:0010901)2.04387881
73Hepatocellular carcinoma (HP:0001402)2.03970588
74Myocardial infarction (HP:0001658)2.01580147
75Abnormal hand bone ossification (HP:0010660)2.00666584
76Enlarged kidneys (HP:0000105)1.96465450
77Megaloblastic anemia (HP:0001889)1.93688975
78Abnormality of sulfur amino acid metabolism (HP:0004339)1.93123216
79Hyperphosphaturia (HP:0003109)1.92451852
80Abnormality of vitamin metabolism (HP:0100508)1.90081139
81Poikilocytosis (HP:0004447)1.88743457
82Hydroxyprolinuria (HP:0003080)1.83574102
83Abnormality of proline metabolism (HP:0010907)1.83574102
84Lower limb hyperreflexia (HP:0002395)1.83097756
85Abnormal ossification of hand bones (HP:0005921)1.81593066
86Nausea (HP:0002018)1.77733901
87Abnormality of nucleobase metabolism (HP:0010932)1.76606282
88Elevated alkaline phosphatase (HP:0003155)1.75138304
89Potter facies (HP:0002009)1.75054125
90Facial shape deformation (HP:0011334)1.75054125
91Increased serum pyruvate (HP:0003542)1.73199809
92Striae distensae (HP:0001065)1.72740056
93Abnormal foot bone ossification (HP:0010675)1.72039000
94Retinal atrophy (HP:0001105)1.70413408
95Capillary hemangiomas (HP:0005306)1.70161438
96Male infertility (HP:0003251)1.68100823
97Abnormality of alkaline phosphatase activity (HP:0004379)1.67130194
98Abnormal enzyme/coenzyme activity (HP:0012379)1.65935631
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62868614
100Hypophosphatemia (HP:0002148)1.60193512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.44010472
2ARAF4.44142363
3MAP3K134.36887593
4FGFR44.08135211
5CDK123.26918105
6FGFR32.67960007
7STK242.44684061
8WNK42.29072615
9TAOK32.26103158
10NEK62.17850914
11KSR22.17607779
12LATS12.00646068
13ICK1.98061349
14TTK1.92188380
15MET1.86472408
16BRAF1.76216270
17CDK91.67752601
18CDK71.66108981
19NEK91.53511263
20PIK3CA1.52453434
21ERN11.52309572
22TYRO31.51565525
23MOS1.50586238
24EIF2AK31.45332954
25LATS21.38140551
26RAF11.35322221
27WNK11.35311857
28AURKA1.32178602
29MELK1.31432285
30MAPKAPK31.27330477
31PRKAA21.25287193
32NEK21.17076196
33NTRK31.14436183
34MAPK111.11965969
35BRSK21.07037271
36FGFR21.04260861
37RET1.03802224
38PDPK11.02799568
39FGFR11.00287173
40RIPK11.00048151
41NTRK20.99641623
42BRSK10.93275702
43ZAK0.91140111
44PLK10.86363807
45STK390.85505467
46STK30.85368763
47PRKCI0.82264753
48EPHA40.81292077
49PDK10.79771473
50NLK0.78975374
51CSNK1E0.78001135
52EEF2K0.76674676
53EIF2AK10.75660230
54CDK80.72440853
55PRKG10.71071040
56ACVR1B0.69781022
57DYRK1B0.66636644
58CSNK1D0.66450301
59STK38L0.64294298
60MAP3K50.63117477
61CDC70.63098115
62AKT30.61480224
63MAP3K10.59839276
64PRKCZ0.59526290
65PTK20.59464396
66PIK3CG0.59223616
67PRKACG0.59118527
68PKN20.56390459
69TNIK0.53514607
70PLK30.52555263
71TESK20.52370894
72MAP3K80.49504851
73PRKAA10.46599224
74MTOR0.46568952
75CDK20.46563698
76PDGFRA0.45964650
77ERBB20.44587720
78MAP3K20.44239030
79BCKDK0.43612695
80PRKACB0.40434660
81AURKB0.38837941
82RPS6KB10.38799865
83PRKACA0.37701807
84NME10.37580815
85TRIB30.37119652
86CHEK10.36971911
87CDK10.36411729
88CSNK2A20.35659177
89IGF1R0.35650664
90PIM10.35252225
91TGFBR20.35116335
92ATM0.33537988
93NUAK10.32669498
94MAP3K30.31758281
95AKT20.30850820
96PBK0.30488371
97CSNK2A10.30260354
98STK160.30253028
99CSNK1G10.28740628
100SGK10.27532117

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.31843825
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.90808802
3Caffeine metabolism_Homo sapiens_hsa002323.79774359
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22672736
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.00679131
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.76306191
7Retinol metabolism_Homo sapiens_hsa008302.67174965
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57130573
9Arginine biosynthesis_Homo sapiens_hsa002202.53466298
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46581817
11Chemical carcinogenesis_Homo sapiens_hsa052042.43901800
12Fatty acid degradation_Homo sapiens_hsa000712.30762066
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.30288539
14Phenylalanine metabolism_Homo sapiens_hsa003602.19385752
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.17643622
16Histidine metabolism_Homo sapiens_hsa003402.12668943
17Fat digestion and absorption_Homo sapiens_hsa049752.12444150
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.08915088
19Butanoate metabolism_Homo sapiens_hsa006502.01265122
20Bile secretion_Homo sapiens_hsa049762.00599892
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93443106
22Tyrosine metabolism_Homo sapiens_hsa003501.86163091
23PPAR signaling pathway_Homo sapiens_hsa033201.80311359
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78250951
25Vitamin digestion and absorption_Homo sapiens_hsa049771.64514671
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58847638
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.57857534
28Starch and sucrose metabolism_Homo sapiens_hsa005001.51223766
29Tryptophan metabolism_Homo sapiens_hsa003801.46908006
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.44501584
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38662130
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.38454628
33Fatty acid metabolism_Homo sapiens_hsa012121.34027143
34Steroid biosynthesis_Homo sapiens_hsa001001.33637784
35Arginine and proline metabolism_Homo sapiens_hsa003301.32266276
36Peroxisome_Homo sapiens_hsa041461.29491904
37ABC transporters_Homo sapiens_hsa020101.29412311
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27387871
39Propanoate metabolism_Homo sapiens_hsa006401.24169693
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20170929
41Linoleic acid metabolism_Homo sapiens_hsa005911.19782678
42Vitamin B6 metabolism_Homo sapiens_hsa007501.12927191
43Pyruvate metabolism_Homo sapiens_hsa006201.10041308
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06042150
45Staphylococcus aureus infection_Homo sapiens_hsa051501.05521312
46Fatty acid elongation_Homo sapiens_hsa000621.05142454
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00552087
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97759723
49beta-Alanine metabolism_Homo sapiens_hsa004100.88953839
50Biosynthesis of amino acids_Homo sapiens_hsa012300.87108896
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87061214
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.83157968
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83057335
54Fatty acid biosynthesis_Homo sapiens_hsa000610.78478683
55Basal transcription factors_Homo sapiens_hsa030220.76627991
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73771085
57Arachidonic acid metabolism_Homo sapiens_hsa005900.70005668
58Carbon metabolism_Homo sapiens_hsa012000.68282687
59Folate biosynthesis_Homo sapiens_hsa007900.64817574
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63387392
61Prion diseases_Homo sapiens_hsa050200.61721140
62One carbon pool by folate_Homo sapiens_hsa006700.57227089
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56743567
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55129367
65Ovarian steroidogenesis_Homo sapiens_hsa049130.54629257
66Glycerolipid metabolism_Homo sapiens_hsa005610.52044054
67Renin-angiotensin system_Homo sapiens_hsa046140.51888267
68Lysine degradation_Homo sapiens_hsa003100.50872226
69Metabolic pathways_Homo sapiens_hsa011000.50358637
70Sulfur metabolism_Homo sapiens_hsa009200.46651405
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44241176
72Fructose and mannose metabolism_Homo sapiens_hsa000510.37202162
73Glutathione metabolism_Homo sapiens_hsa004800.37039611
74Other glycan degradation_Homo sapiens_hsa005110.36158257
75Cell cycle_Homo sapiens_hsa041100.35212917
76Mineral absorption_Homo sapiens_hsa049780.33718957
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31929155
78Oocyte meiosis_Homo sapiens_hsa041140.26495937
79Circadian rhythm_Homo sapiens_hsa047100.26263483
80Sulfur relay system_Homo sapiens_hsa041220.23747600
81Insulin resistance_Homo sapiens_hsa049310.23644323
82Galactose metabolism_Homo sapiens_hsa000520.22885321
83Sphingolipid metabolism_Homo sapiens_hsa006000.20208682
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.18074690
85N-Glycan biosynthesis_Homo sapiens_hsa005100.17595868
86Base excision repair_Homo sapiens_hsa034100.17107538
87Mismatch repair_Homo sapiens_hsa034300.15268757
88Pentose phosphate pathway_Homo sapiens_hsa000300.08621876
89Pertussis_Homo sapiens_hsa051330.08142140
90RNA degradation_Homo sapiens_hsa030180.07951994
91Glucagon signaling pathway_Homo sapiens_hsa049220.07758867
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05934301
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04254932
94Thyroid hormone synthesis_Homo sapiens_hsa049180.03892957
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.01613234
96Protein digestion and absorption_Homo sapiens_hsa049740.00730622
97Ether lipid metabolism_Homo sapiens_hsa005650.00706319
98Nucleotide excision repair_Homo sapiens_hsa034200.00227547
99Selenocompound metabolism_Homo sapiens_hsa00450-0.0062368
100Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0029152

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »