ABCC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06964649
2neuronal action potential propagation (GO:0019227)5.04084126
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77239688
4ionotropic glutamate receptor signaling pathway (GO:0035235)4.72275136
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62465025
6cilium or flagellum-dependent cell motility (GO:0001539)4.49469849
7vocalization behavior (GO:0071625)4.48162840
8axonemal dynein complex assembly (GO:0070286)4.47077174
9neuron cell-cell adhesion (GO:0007158)4.32891980
10synaptic vesicle maturation (GO:0016188)4.21239951
11locomotory exploration behavior (GO:0035641)4.14804057
12postsynaptic membrane organization (GO:0001941)4.13943156
13positive regulation of action potential (GO:0045760)4.13386643
14protein localization to synapse (GO:0035418)4.12980485
15cytoskeletal anchoring at plasma membrane (GO:0007016)4.06786638
16presynaptic membrane assembly (GO:0097105)4.06505345
17motile cilium assembly (GO:0044458)4.03062113
18regulation of glutamate receptor signaling pathway (GO:1900449)4.01292754
19glutamate receptor signaling pathway (GO:0007215)3.98724919
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93239065
21synaptic vesicle exocytosis (GO:0016079)3.86002203
22synaptic transmission, glutamatergic (GO:0035249)3.83463644
23presynaptic membrane organization (GO:0097090)3.78619263
24regulation of synaptic vesicle exocytosis (GO:2000300)3.70733625
25urinary tract smooth muscle contraction (GO:0014848)3.68104795
26cell migration in hindbrain (GO:0021535)3.64717667
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63557520
28dendritic spine morphogenesis (GO:0060997)3.58094308
29neuron-neuron synaptic transmission (GO:0007270)3.54953085
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52143169
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48174438
32positive regulation of membrane potential (GO:0045838)3.45526282
33transmission of nerve impulse (GO:0019226)3.45017331
34L-amino acid import (GO:0043092)3.44373098
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43155817
36long-term memory (GO:0007616)3.42901567
37regulation of synapse structural plasticity (GO:0051823)3.41858830
38positive regulation of dendritic spine development (GO:0060999)3.39572587
39cilium movement (GO:0003341)3.39356097
40gamma-aminobutyric acid transport (GO:0015812)3.38332056
41auditory behavior (GO:0031223)3.37228138
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.37067497
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31528453
44regulation of postsynaptic membrane potential (GO:0060078)3.30684487
45glutamate secretion (GO:0014047)3.30132281
46regulation of neuronal synaptic plasticity (GO:0048168)3.29767088
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27213427
48regulation of synaptic vesicle transport (GO:1902803)3.25658004
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24278794
50cerebellar Purkinje cell differentiation (GO:0021702)3.24246896
51cell communication by electrical coupling (GO:0010644)3.22777203
52exploration behavior (GO:0035640)3.22510925
53histone H3-K9 demethylation (GO:0033169)3.18867588
54regulation of ARF protein signal transduction (GO:0032012)3.15610189
55neurotransmitter-gated ion channel clustering (GO:0072578)3.15513840
56neurotransmitter secretion (GO:0007269)3.14772869
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.12818435
58response to auditory stimulus (GO:0010996)3.10851228
59adult walking behavior (GO:0007628)3.10267880
60membrane depolarization during action potential (GO:0086010)3.08534483
61layer formation in cerebral cortex (GO:0021819)3.08366859
62cell communication involved in cardiac conduction (GO:0086065)3.08279909
63membrane depolarization (GO:0051899)3.08268877
64neuronal ion channel clustering (GO:0045161)3.07306372
65apical protein localization (GO:0045176)3.07064783
66positive regulation of synapse maturation (GO:0090129)3.04573166
67neuron recognition (GO:0008038)3.03535811
68cellular potassium ion homeostasis (GO:0030007)3.03119703
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01516260
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99225929
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98883947
72neuromuscular process controlling balance (GO:0050885)2.95834651
73activation of protein kinase A activity (GO:0034199)2.95522650
74mechanosensory behavior (GO:0007638)2.94747531
75negative regulation of inclusion body assembly (GO:0090084)2.93590809
76intracellular estrogen receptor signaling pathway (GO:0030520)2.93028000
77regulation of respiratory system process (GO:0044065)2.92744031
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92735721
79positive regulation of dendritic spine morphogenesis (GO:0061003)2.92313104
80negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90813226
81semaphorin-plexin signaling pathway (GO:0071526)2.89339099
82positive regulation of neurotransmitter secretion (GO:0001956)2.89011418
83ear development (GO:0043583)2.88494514
84positive regulation of synapse assembly (GO:0051965)2.88233430
85neuromuscular process controlling posture (GO:0050884)2.87176670
86regulation of dendritic spine morphogenesis (GO:0061001)2.86945697
87amino acid import (GO:0043090)2.85878304
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84842620
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.84093166
90regulation of dendritic spine development (GO:0060998)2.83806599
91sarcoplasmic reticulum calcium ion transport (GO:0070296)2.83504250
92synaptic vesicle endocytosis (GO:0048488)2.83346628
93iron ion import (GO:0097286)2.82408135
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82115961
95regulation of neurotransmitter secretion (GO:0046928)2.81607404
96proline transport (GO:0015824)2.81057291
97synapse assembly (GO:0007416)2.80818317
98central nervous system myelination (GO:0022010)2.80270099
99axon ensheathment in central nervous system (GO:0032291)2.80270099
100neurotransmitter transport (GO:0006836)2.79457747
101glycine transport (GO:0015816)2.78861054
102axonal fasciculation (GO:0007413)2.77028169
103positive regulation of neurotransmitter transport (GO:0051590)2.76204666
104membrane hyperpolarization (GO:0060081)2.75762423
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75022169
106dendrite morphogenesis (GO:0048813)2.74916217
107regulation of vesicle fusion (GO:0031338)2.73398126
108cardiac muscle contraction (GO:0060048)2.73192811
109learning (GO:0007612)2.72650523
110regulation of respiratory gaseous exchange (GO:0043576)2.71278015
111righting reflex (GO:0060013)2.71018365
112central nervous system projection neuron axonogenesis (GO:0021952)2.69954848
113regulation of synaptic plasticity (GO:0048167)2.68564506
114regulation of clathrin-mediated endocytosis (GO:2000369)2.68515582
115peptidyl-tyrosine autophosphorylation (GO:0038083)2.66216873
116regulation of synaptic transmission, GABAergic (GO:0032228)2.62972890
117sodium ion export (GO:0071436)2.62703351
118diterpenoid biosynthetic process (GO:0016102)2.62065169
119startle response (GO:0001964)2.61242579
120regulation of neurotransmitter transport (GO:0051588)2.60649835
121regulation of voltage-gated calcium channel activity (GO:1901385)2.58824029
122cerebellar granule cell differentiation (GO:0021707)2.58727140
123mating behavior (GO:0007617)2.57748671
124prepulse inhibition (GO:0060134)2.57616270
125visual learning (GO:0008542)2.56296910
126regulation of synapse assembly (GO:0051963)2.55319230
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54733061
128long-term synaptic potentiation (GO:0060291)2.54085731
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52789556
130regulation of NFAT protein import into nucleus (GO:0051532)2.52552833
131ventricular cardiac muscle cell action potential (GO:0086005)2.51474502
132asymmetric protein localization (GO:0008105)2.51077233
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50757089
134negative regulation of microtubule polymerization (GO:0031115)2.50443104
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50106629
136striated muscle contraction (GO:0006941)2.47513221
137vitamin transmembrane transport (GO:0035461)2.46397886
138carnitine transmembrane transport (GO:1902603)2.42726289
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.42256634
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.42129299
141regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.40336425
142nerve growth factor signaling pathway (GO:0038180)2.38969551
143positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.38913457
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.38236024
145regulation of synapse maturation (GO:0090128)2.38032407
146negative regulation of dendrite morphogenesis (GO:0050774)2.37509236
147relaxation of cardiac muscle (GO:0055119)2.37026784
148clathrin coat assembly (GO:0048268)2.36036282
149histone lysine demethylation (GO:0070076)2.36033253
150epithelial cilium movement (GO:0003351)2.34120377
151regulation of cell communication by electrical coupling (GO:0010649)2.33867786
152desmosome organization (GO:0002934)2.32856500
153negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32062675
154sarcomere organization (GO:0045214)2.30626893
155histone demethylation (GO:0016577)2.29389055
156potassium ion homeostasis (GO:0055075)2.27958413
157regulation of actin filament-based movement (GO:1903115)2.26988198
158cellular response to monoamine stimulus (GO:0071868)2.26752585
159cellular response to catecholamine stimulus (GO:0071870)2.26752585
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26004838
161left/right pattern formation (GO:0060972)2.24662996
162cell junction maintenance (GO:0034331)2.23366597
163cardiac muscle hypertrophy (GO:0003300)2.22494644
164adherens junction assembly (GO:0034333)2.21245493
165regulation of histone H3-K27 methylation (GO:0061085)2.20227926
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19394141
167skeletal muscle contraction (GO:0003009)2.18863529
168planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18280723
169neuromuscular junction development (GO:0007528)2.16509418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33324048
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.32546680
3GBX2_23144817_ChIP-Seq_PC3_Human3.61699585
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06472553
5* ESR2_21235772_ChIP-Seq_MCF-7_Human3.02203921
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96094823
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79423610
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63696539
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63696539
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54693126
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.50676337
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44126731
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42780305
14DROSHA_22980978_ChIP-Seq_HELA_Human2.40911468
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39378534
16* ESR1_21235772_ChIP-Seq_MCF-7_Human2.34095833
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33048883
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31237359
19REST_21632747_ChIP-Seq_MESCs_Mouse2.27029770
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25854002
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.22873515
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16837029
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12592778
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.12117187
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.03791409
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93734194
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93093089
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91839050
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.85081295
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.72943532
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71295690
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67825206
33AR_21572438_ChIP-Seq_LNCaP_Human1.59949324
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59481168
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58220619
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58168132
37* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58039775
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57908925
39RACK7_27058665_Chip-Seq_MCF-7_Human1.54505070
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52287637
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.50336900
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49558500
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49048637
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48988418
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48179597
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47662481
47SMAD4_21799915_ChIP-Seq_A2780_Human1.47092123
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45315200
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44621808
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44584607
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43600783
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43214974
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41588944
54IGF1R_20145208_ChIP-Seq_DFB_Human1.40459728
55SMC4_20622854_ChIP-Seq_HELA_Human1.40440142
56TAF15_26573619_Chip-Seq_HEK293_Human1.40404472
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.40380168
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39493134
59* GATA1_19941826_ChIP-Seq_K562_Human1.37923739
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.34473754
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33925615
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.32676242
63ZNF263_19887448_ChIP-Seq_K562_Human1.31583522
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.30532802
65CREB1_26743006_Chip-Seq_LNCaP_Human1.29403092
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28258911
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.28021917
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.28021917
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.26717306
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25514011
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24944948
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23255365
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23136156
74P300_19829295_ChIP-Seq_ESCs_Human1.19618668
75TP53_16413492_ChIP-PET_HCT116_Human1.19573502
76LXR_22292898_ChIP-Seq_THP-1_Human1.16876322
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.16515574
78KDM2B_26808549_Chip-Seq_DND41_Human1.16515205
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.16226381
80TCF7_22412390_ChIP-Seq_EML_Mouse1.14058151
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13149481
82* CLOCK_20551151_ChIP-Seq_293T_Human1.13053686
83RNF2_27304074_Chip-Seq_NSC_Mouse1.12334649
84ZNF274_21170338_ChIP-Seq_K562_Hela1.12170703
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12169009
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10017877
87* STAT3_23295773_ChIP-Seq_U87_Human1.09890118
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09800954
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08985126
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08045507
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07246406
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06336291
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.06300007
94AR_25329375_ChIP-Seq_VCAP_Human1.04353815
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04264271
96TCF4_23295773_ChIP-Seq_U87_Human1.03292149
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02409116
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01935812
99RUNX2_22187159_ChIP-Seq_PCA_Human1.01733799
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.01293629
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.00832099
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00435787
103* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00235679
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99839840
105TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99797385
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98675169
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.98598083
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98291059
109* GATA2_19941826_ChIP-Seq_K562_Human0.97723360
110AHR_22903824_ChIP-Seq_MCF-7_Human0.97503831
111PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97204425
112KDM2B_26808549_Chip-Seq_K562_Human0.96873567
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96436014
114AR_19668381_ChIP-Seq_PC3_Human0.96340499
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95215008
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.95090491
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.94521113
118* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94451116
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93999461
120* ARNT_22903824_ChIP-Seq_MCF-7_Human0.93885174
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93859952
122CTCF_27219007_Chip-Seq_Bcells_Human0.93072227
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92988555
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92964540
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.92693513
126* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92530281
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92413129
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92236183
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92068909
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91539535
131* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91202692
132* KLF5_25053715_ChIP-Seq_YYC3_Human0.91074190
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90293185
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89801411
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.89470516
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.88646176
137FUS_26573619_Chip-Seq_HEK293_Human0.88363061
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87615111
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87508074
140ER_23166858_ChIP-Seq_MCF-7_Human0.87485890
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86891591
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.86866358
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85896710
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.85183680
145TP53_18474530_ChIP-ChIP_U2OS_Human0.84757470
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84167295
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84063423
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.83708019
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83114531
150* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82797423
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80762728
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80432523
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79670472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.24968704
2MP0003880_abnormal_central_pattern4.72741705
3MP0003635_abnormal_synaptic_transmissio3.52586065
4MP0004270_analgesia3.33260825
5MP0009046_muscle_twitch3.16195382
6MP0009745_abnormal_behavioral_response2.96597790
7MP0002064_seizures2.87205828
8MP0005423_abnormal_somatic_nervous2.71502383
9MP0001968_abnormal_touch/_nociception2.69191767
10MP0002063_abnormal_learning/memory/cond2.56501366
11MP0002272_abnormal_nervous_system2.52806372
12MP0001486_abnormal_startle_reflex2.48369605
13MP0002734_abnormal_mechanical_nocicepti2.39937775
14MP0002572_abnormal_emotion/affect_behav2.36595572
15MP0005409_darkened_coat_color2.31417810
16MP0001188_hyperpigmentation2.16718956
17MP0005083_abnormal_biliary_tract2.11609704
18MP0008569_lethality_at_weaning2.09337063
19MP0001501_abnormal_sleep_pattern2.04511441
20MP0002067_abnormal_sensory_capabilities2.03057926
21MP0002735_abnormal_chemical_nociception2.01479066
22MP0002822_catalepsy1.96711352
23MP0001970_abnormal_pain_threshold1.95604489
24MP0002736_abnormal_nociception_after1.93396436
25MP0000569_abnormal_digit_pigmentation1.90114556
26MP0002733_abnormal_thermal_nociception1.89708727
27MP0004036_abnormal_muscle_relaxation1.83254799
28MP0001440_abnormal_grooming_behavior1.80559331
29MP0004264_abnormal_extraembryonic_tissu1.74783877
30MP0002184_abnormal_innervation1.74183957
31MP0000778_abnormal_nervous_system1.72590402
32MP0003136_yellow_coat_color1.71296467
33MP0005174_abnormal_tail_pigmentation1.71189422
34MP0004858_abnormal_nervous_system1.70654271
35MP0004233_abnormal_muscle_weight1.69132142
36MP0003656_abnormal_erythrocyte_physiolo1.68576812
37MP0004084_abnormal_cardiac_muscle1.61560147
38MP0002557_abnormal_social/conspecific_i1.54455238
39MP0010234_abnormal_vibrissa_follicle1.53300404
40MP0004145_abnormal_muscle_electrophysio1.53138857
41MP0000383_abnormal_hair_follicle1.53007204
42MP0003879_abnormal_hair_cell1.52528828
43MP0000955_abnormal_spinal_cord1.51747993
44MP0004142_abnormal_muscle_tone1.50194115
45MP0006276_abnormal_autonomic_nervous1.47947406
46MP0001346_abnormal_lacrimal_gland1.47469964
47MP0000920_abnormal_myelination1.46110625
48MP0000015_abnormal_ear_pigmentation1.45888497
49MP0000747_muscle_weakness1.45797809
50MP0004924_abnormal_behavior1.41070497
51MP0005386_behavior/neurological_phenoty1.41070497
52MP0002882_abnormal_neuron_morphology1.40474750
53MP0010678_abnormal_skin_adnexa1.39900310
54MP0004811_abnormal_neuron_physiology1.38730069
55MP0004885_abnormal_endolymph1.36965817
56MP0004087_abnormal_muscle_fiber1.34686580
57MP0001984_abnormal_olfaction1.33905090
58MP0003705_abnormal_hypodermis_morpholog1.30842040
59MP0005248_abnormal_Harderian_gland1.30442842
60MP0002653_abnormal_ependyma_morphology1.30412828
61MP0000749_muscle_degeneration1.26985003
62MP0000751_myopathy1.26559059
63MP0004130_abnormal_muscle_cell1.26366606
64MP0000579_abnormal_nail_morphology1.25903439
65MP0003172_abnormal_lysosome_physiology1.25474213
66MP0003633_abnormal_nervous_system1.25161810
67MP0002066_abnormal_motor_capabilities/c1.23525059
68MP0010630_abnormal_cardiac_muscle1.23002146
69MP0004742_abnormal_vestibular_system1.22388682
70MP0004147_increased_porphyrin_level1.21842748
71MP0001502_abnormal_circadian_rhythm1.18305821
72MP0003634_abnormal_glial_cell1.18203651
73MP0005646_abnormal_pituitary_gland1.18149393
74MP0005171_absent_coat_pigmentation1.16417696
75MP0002229_neurodegeneration1.16305878
76MP0005645_abnormal_hypothalamus_physiol1.15849510
77MP0006292_abnormal_olfactory_placode1.15801892
78MP0006138_congestive_heart_failure1.10787353
79MP0003329_amyloid_beta_deposits1.08892349
80MP0003283_abnormal_digestive_organ1.07359940
81MP0001905_abnormal_dopamine_level1.07270469
82MP0002269_muscular_atrophy1.07264660
83MP0002638_abnormal_pupillary_reflex1.06413908
84MP0005076_abnormal_cell_differentiation1.03693278
85MP0001849_ear_inflammation1.02985056
86MP0009672_abnormal_birth_weight1.02967448
87MP0000537_abnormal_urethra_morphology1.02586188
88MP0002909_abnormal_adrenal_gland1.02290335
89MP0003690_abnormal_glial_cell1.02151417
90MP0003631_nervous_system_phenotype1.01588563
91MP0005551_abnormal_eye_electrophysiolog1.00225387
92MP0009780_abnormal_chondrocyte_physiolo0.99568062
93MP0002152_abnormal_brain_morphology0.99385044
94MP0004215_abnormal_myocardial_fiber0.98967717
95MP0000631_abnormal_neuroendocrine_gland0.98629446
96MP0002249_abnormal_larynx_morphology0.95580835
97MP0002098_abnormal_vibrissa_morphology0.94795549
98MP0002752_abnormal_somatic_nervous0.94606536
99MP0000759_abnormal_skeletal_muscle0.93751996
100MP0001963_abnormal_hearing_physiology0.92603501
101MP0004484_altered_response_of0.91948301
102MP0001529_abnormal_vocalization0.91408478
103MP0009384_cardiac_valve_regurgitation0.90853811
104MP0002972_abnormal_cardiac_muscle0.89584508
105MP0010386_abnormal_urinary_bladder0.87021670
106MP0001986_abnormal_taste_sensitivity0.85808529
107MP0003787_abnormal_imprinting0.85444668
108MP0002108_abnormal_muscle_morphology0.85310708
109MP0002796_impaired_skin_barrier0.85128331
110MP0005620_abnormal_muscle_contractility0.84558168
111MP0002106_abnormal_muscle_physiology0.84261955
112MP0009703_decreased_birth_body0.84156054
113MP0004185_abnormal_adipocyte_glucose0.82590630
114MP0003122_maternal_imprinting0.82468857
115MP0005187_abnormal_penis_morphology0.82377623
116MP0005369_muscle_phenotype0.79944707
117MP0005167_abnormal_blood-brain_barrier0.79589665
118MP0001485_abnormal_pinna_reflex0.79400299
119MP0002896_abnormal_bone_mineralization0.78990267
120MP0003632_abnormal_nervous_system0.78210977
121MP0008260_abnormal_autophagy0.78028771
122MP0008995_early_reproductive_senescence0.77698282
123MP0008775_abnormal_heart_ventricle0.77062876
124MP0003861_abnormal_nervous_system0.76942964
125MP0003938_abnormal_ear_development0.75012834
126MP0009379_abnormal_foot_pigmentation0.74875665
127MP0005330_cardiomyopathy0.74841491
128MP0003075_altered_response_to0.74770728
129MP0008874_decreased_physiological_sensi0.74112256
130MP0005377_hearing/vestibular/ear_phenot0.74050984
131MP0001177_atelectasis0.69341875
132MP0003646_muscle_fatigue0.68561941
133MP0002751_abnormal_autonomic_nervous0.67087358
134MP0000026_abnormal_inner_ear0.63675148
135MP0005499_abnormal_olfactory_system0.63342372
136MP0005394_taste/olfaction_phenotype0.63342372
137MP0003137_abnormal_impulse_conducting0.60761637
138MP0002177_abnormal_outer_ear0.59906585
139MP0002095_abnormal_skin_pigmentation0.59735545
140MP0004510_myositis0.58617929
141MP0002102_abnormal_ear_morphology0.58585839
142MP0001299_abnormal_eye_distance/0.57679310
143MP0002069_abnormal_eating/drinking_beha0.57521147
144MP0005058_abnormal_lysosome_morphology0.57455081
145MP0003045_fibrosis0.57052118
146MP0006072_abnormal_retinal_apoptosis0.55039119
147MP0004085_abnormal_heartbeat0.53161485

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.66407736
2Myokymia (HP:0002411)5.24809143
3Focal seizures (HP:0007359)4.98542750
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.67745751
5Abnormal respiratory epithelium morphology (HP:0012253)4.63687521
6Abnormal respiratory motile cilium morphology (HP:0005938)4.63687521
7Abnormal ciliary motility (HP:0012262)4.40875279
8Febrile seizures (HP:0002373)4.39030414
9Abnormal respiratory motile cilium physiology (HP:0012261)4.22430808
10Epileptic encephalopathy (HP:0200134)3.94807975
11Atonic seizures (HP:0010819)3.86957636
12Progressive cerebellar ataxia (HP:0002073)3.86816144
13Supranuclear gaze palsy (HP:0000605)3.75280635
14Action tremor (HP:0002345)3.69204364
15Visual hallucinations (HP:0002367)3.67668107
16Gaze-evoked nystagmus (HP:0000640)3.63793254
17Rhinitis (HP:0012384)3.53939096
18Broad-based gait (HP:0002136)3.47545032
19Bundle branch block (HP:0011710)3.26902185
20Hemiparesis (HP:0001269)3.19465212
21Dialeptic seizures (HP:0011146)3.05876724
22Absence seizures (HP:0002121)3.03023794
23Distal lower limb muscle weakness (HP:0009053)2.98738094
24Ankle clonus (HP:0011448)2.97258594
25Progressive inability to walk (HP:0002505)2.94069434
26EMG: neuropathic changes (HP:0003445)2.90250000
27Generalized tonic-clonic seizures (HP:0002069)2.86261206
28Chronic bronchitis (HP:0004469)2.85483960
29Peripheral hypomyelination (HP:0007182)2.84586534
30Dysmetria (HP:0001310)2.83649683
31Nonprogressive disorder (HP:0003680)2.83411644
32Muscle fiber splitting (HP:0003555)2.82524812
33Sudden death (HP:0001699)2.81178352
34Hyporeflexia of lower limbs (HP:0002600)2.78946420
35Exercise-induced myalgia (HP:0003738)2.75134709
36Scanning speech (HP:0002168)2.72828546
37Dysdiadochokinesis (HP:0002075)2.64396334
38Hypothermia (HP:0002045)2.62557537
39Truncal ataxia (HP:0002078)2.59428392
40Depression (HP:0000716)2.59000460
41Urinary bladder sphincter dysfunction (HP:0002839)2.57152962
42Mutism (HP:0002300)2.54981108
43Absent speech (HP:0001344)2.52265781
44Diplopia (HP:0000651)2.51533943
45Abnormality of binocular vision (HP:0011514)2.51533943
46Right ventricular cardiomyopathy (HP:0011663)2.49474336
47Ventricular fibrillation (HP:0001663)2.48928883
48Male infertility (HP:0003251)2.44790132
49Germ cell neoplasia (HP:0100728)2.43651812
50Termporal pattern (HP:0011008)2.40219396
51Insidious onset (HP:0003587)2.40219396
52Syncope (HP:0001279)2.39816035
53Hemiplegia (HP:0002301)2.39290984
54Genetic anticipation (HP:0003743)2.33341729
55Poor eye contact (HP:0000817)2.30138069
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.29380240
57Dysmetric saccades (HP:0000641)2.29263193
58Bronchiectasis (HP:0002110)2.29069243
59Excessive salivation (HP:0003781)2.27448779
60Drooling (HP:0002307)2.27448779
61Nasal polyposis (HP:0100582)2.26812940
62Abnormal eating behavior (HP:0100738)2.26663589
63Neuronal loss in central nervous system (HP:0002529)2.26239940
64Postural instability (HP:0002172)2.26011141
65Anxiety (HP:0000739)2.26010798
66Spastic gait (HP:0002064)2.24036106
67Obstructive sleep apnea (HP:0002870)2.23801389
68Impaired smooth pursuit (HP:0007772)2.22345697
69Testicular neoplasm (HP:0010788)2.22145990
70Abnormality of the calf musculature (HP:0001430)2.20714565
71Lip pit (HP:0100267)2.20604592
72Infertility (HP:0000789)2.19591778
73Neurofibrillary tangles (HP:0002185)2.16093566
74Ulnar claw (HP:0001178)2.14836944
75Bradycardia (HP:0001662)2.14499253
76Stereotypic behavior (HP:0000733)2.11874558
77Cortical visual impairment (HP:0100704)2.10937048
78Bell-shaped thorax (HP:0001591)2.09353720
79Absent frontal sinuses (HP:0002688)2.08395128
80Reticulocytosis (HP:0001923)2.06602738
81Lower limb amyotrophy (HP:0007210)2.06499473
82Protruding tongue (HP:0010808)2.05779443
83Difficulty running (HP:0009046)2.04212057
84Impaired vibration sensation in the lower limbs (HP:0002166)2.04100694
85Abnormality of the foot musculature (HP:0001436)2.02042666
86Hyperkalemia (HP:0002153)2.01278619
87Onion bulb formation (HP:0003383)2.00713886
88Foot dorsiflexor weakness (HP:0009027)2.00666968
89Thyroid-stimulating hormone excess (HP:0002925)1.98255572
90Abnormal social behavior (HP:0012433)1.98076139
91Impaired social interactions (HP:0000735)1.98076139
92Amblyopia (HP:0000646)1.97301789
93Distal lower limb amyotrophy (HP:0008944)1.97133177
94Abnormality of the corticospinal tract (HP:0002492)1.94644689
95Heart block (HP:0012722)1.94543871
96Abnormality of ocular smooth pursuit (HP:0000617)1.94139326
97Papillary thyroid carcinoma (HP:0002895)1.93935736
98Bowel incontinence (HP:0002607)1.93816796
99Asymmetric septal hypertrophy (HP:0001670)1.93563324
100Spinal muscular atrophy (HP:0007269)1.93432062
101Lower limb muscle weakness (HP:0007340)1.92571424
102Horizontal nystagmus (HP:0000666)1.92532173
103Slow saccadic eye movements (HP:0000514)1.92369265
104Inability to walk (HP:0002540)1.92128840
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91328437
106Abnormality of the left ventricular outflow tract (HP:0011103)1.90456195
107Subaortic stenosis (HP:0001682)1.90456195
108Intention tremor (HP:0002080)1.90051432
109Myopathic facies (HP:0002058)1.89668252
110Annular pancreas (HP:0001734)1.88871861
111Iris hypopigmentation (HP:0007730)1.87184199
112Metaphyseal cupping (HP:0003021)1.87106539
113Muscle hypertrophy of the lower extremities (HP:0008968)1.86928412
114Flat acetabular roof (HP:0003180)1.86742608
115Esotropia (HP:0000565)1.86406301
116Atelectasis (HP:0100750)1.86295180
117Diaphragmatic weakness (HP:0009113)1.86190299
118Fetal akinesia sequence (HP:0001989)1.86122764
119Retinal dysplasia (HP:0007973)1.85844262
120Ventricular tachycardia (HP:0004756)1.85634589
121Clumsiness (HP:0002312)1.85519011
122Abnormality of the salivary glands (HP:0010286)1.84343932
123EMG: myopathic abnormalities (HP:0003458)1.83694631
124Hyperacusis (HP:0010780)1.82900708
125Calf muscle hypertrophy (HP:0008981)1.82256704
126Abnormal atrioventricular conduction (HP:0005150)1.81448567
127Asymmetry of the thorax (HP:0001555)1.81093551
128Ocular albinism (HP:0001107)1.79767778
129Abnormality of the nasal mucosa (HP:0000433)1.79413787
130Macroglossia (HP:0000158)1.79408898
131Ventricular arrhythmia (HP:0004308)1.78879525
132Blue irides (HP:0000635)1.78814153
133Widely spaced teeth (HP:0000687)1.78435869
134Limb dystonia (HP:0002451)1.77274023
135Abnormal large intestine physiology (HP:0012700)1.77117907
136Decreased motor nerve conduction velocity (HP:0003431)1.76678345
137Macroorchidism (HP:0000053)1.76510742
138Bradykinesia (HP:0002067)1.76368544
139Hand muscle atrophy (HP:0009130)1.76315805
140Akinesia (HP:0002304)1.75992754
141Aplasia involving bones of the upper limbs (HP:0009823)1.74705321
142Aplasia of the phalanges of the hand (HP:0009802)1.74705321
143Aplasia involving bones of the extremities (HP:0009825)1.74705321
144Absent/shortened dynein arms (HP:0200106)1.74615490
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.74615490
146Septate vagina (HP:0001153)1.74375229
147Rapidly progressive (HP:0003678)1.73942618
148Tubulointerstitial nephritis (HP:0001970)1.73838226
149Urinary urgency (HP:0000012)1.73752227
150Insomnia (HP:0100785)1.73738467
151Inappropriate behavior (HP:0000719)1.72716432
152Abnormality of the dental root (HP:0006486)1.72711387
153Taurodontia (HP:0000679)1.72711387
154Abnormality of permanent molar morphology (HP:0011071)1.72711387
155Muscle fiber inclusion bodies (HP:0100299)1.72046470
156Steppage gait (HP:0003376)1.71667315
157Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71127398
158Degeneration of the lateral corticospinal tracts (HP:0002314)1.71127398
159Split foot (HP:0001839)1.71001025
160Hyperventilation (HP:0002883)1.70125241
161Abnormality of saccadic eye movements (HP:0000570)1.69919729
162Psychosis (HP:0000709)1.69852502
163Hammertoe (HP:0001765)1.69203628
164Agitation (HP:0000713)1.68455024
165Abnormality of salivation (HP:0100755)1.68436578
166Severe visual impairment (HP:0001141)1.65960596
167Deeply set eye (HP:0000490)1.65912004
168Specific learning disability (HP:0001328)1.64809222
169Cerebral inclusion bodies (HP:0100314)1.63701361
170Pointed chin (HP:0000307)1.60962800
171Spinal canal stenosis (HP:0003416)1.58924699
172Torticollis (HP:0000473)1.57566111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.03726681
2TRIB34.08619995
3NTRK33.61980502
4CASK3.26000337
5EPHA43.16282405
6PKN22.96732069
7RIPK42.89682655
8CDK122.86915321
9MUSK2.63177658
10MAP3K92.43807983
11FES2.19430938
12CAMKK22.16203211
13MAP2K72.05166577
14MARK12.03959393
15EEF2K2.00204053
16DAPK21.97432786
17PRPF4B1.94833326
18CDK191.85919607
19OBSCN1.83084350
20NTRK21.81140221
21MAPKAPK31.78118227
22MAP3K41.77053634
23SIK21.71065249
24MAPK151.70000399
25PAK61.66975551
26MINK11.61757717
27NTRK11.57903320
28SCYL21.54810800
29CAMK11.50197731
30MAPK131.47254082
31CAMKK11.46574014
32EPHA21.45324482
33UHMK11.41009509
34RET1.38597333
35ICK1.35723937
36FGR1.34311254
37CDK51.31731815
38BRD41.31166986
39LATS21.28054539
40TTN1.26223873
41DMPK1.25428608
42PHKG21.20577618
43PHKG11.20577618
44MAP3K121.19298369
45SIK11.18279759
46MAP3K61.17557247
47RPS6KA21.17254604
48MAP3K131.14444061
49STK381.13561206
50SGK21.12552415
51PNCK1.12099795
52GRK51.11349414
53MARK21.09507429
54KSR21.09326596
55WNK11.07930998
56OXSR11.07231425
57EPHB11.03728160
58DAPK11.03402116
59SGK31.01793830
60MTOR1.01041233
61MAPK120.98580258
62CAMK2B0.98225828
63RPS6KB20.98127799
64YES10.94976390
65MKNK20.92412208
66CAMK1G0.88579168
67CAMK2A0.88205175
68MAP2K40.85835224
69CAMK2G0.84441093
70MAP2K10.83271173
71MAPKAPK50.79751090
72RPS6KB10.79704685
73TNK20.79010352
74TAOK10.77240759
75PRKD20.76621102
76CSNK1G20.74587642
77TRPM70.74170768
78RAF10.74024086
79SMG10.73610244
80ERBB20.72710347
81EPHA30.72481628
82PRKD10.72385740
83PRKAA10.72352536
84TYRO30.72082865
85CAMK40.71835669
86PRKCG0.68902885
87SGK10.68061596
88STK110.67915695
89NEK60.67809619
90PAK30.67799690
91ADRBK20.67531761
92GRK70.67192383
93PINK10.66376474
94PRKCZ0.64696124
95RIPK10.64461725
96PRKAA20.64008000
97FGFR40.63956769
98CAMK2D0.63572717
99MATK0.62568668
100PDGFRA0.60036051
101SGK2230.59989482
102SGK4940.59989482
103FGFR20.59914192
104FYN0.59897195
105CSNK1A1L0.58387812
106PRKCH0.57742929
107IRAK20.57712480
108MAP3K10.57057503
109PTK60.56410547
110CDC42BPA0.54416258
111MAP3K20.54184377
112BCR0.53098432
113DDR20.52256324
114NME10.51374904
115PIK3CA0.50946813
116PKN10.50787286
117PTK2B0.50761475
118RPS6KC10.50441055
119RPS6KL10.50441055
120STK160.50313497
121CDK150.50297265
122PRKCE0.50271200
123DYRK1A0.50164737
124PRKD30.50081025
125MAP3K70.50009421
126PDK10.49643229
127PDGFRB0.48385688
128KIT0.47635038
129CDK11A0.47354116
130CDK180.47210155
131STK390.46799946
132MAPK100.46784024
133CLK10.46325749
134MAPK80.44907319
135PLK20.44811152
136PRKG10.44677649
137CSNK1G30.44273721
138CDK140.44228418
139TESK10.44104597
140PTK20.44079058
141HIPK20.42878873
142FER0.42576907
143PDPK10.39882470
144KSR10.39458964
145RPS6KA30.39109310
146ROCK20.38206082
147DAPK30.38200899
148ARAF0.38200379
149BMPR20.38091643
150HCK0.37931389
151CAMK1D0.35945589
152WNK30.35674105

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38484242
2Synaptic vesicle cycle_Homo sapiens_hsa047212.49648384
3Glutamatergic synapse_Homo sapiens_hsa047242.43391257
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35519742
5Olfactory transduction_Homo sapiens_hsa047402.34640694
6Morphine addiction_Homo sapiens_hsa050322.29408411
7Circadian entrainment_Homo sapiens_hsa047132.28231568
8GABAergic synapse_Homo sapiens_hsa047272.26860454
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03300531
10Long-term potentiation_Homo sapiens_hsa047202.01248997
11Salivary secretion_Homo sapiens_hsa049701.91995554
12Taste transduction_Homo sapiens_hsa047421.83384874
13Amphetamine addiction_Homo sapiens_hsa050311.80146428
14Long-term depression_Homo sapiens_hsa047301.72529528
15Dopaminergic synapse_Homo sapiens_hsa047281.68200832
16Cholinergic synapse_Homo sapiens_hsa047251.67026294
17Serotonergic synapse_Homo sapiens_hsa047261.66085181
18Calcium signaling pathway_Homo sapiens_hsa040201.59021293
19Insulin secretion_Homo sapiens_hsa049111.58565202
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57784882
21Gastric acid secretion_Homo sapiens_hsa049711.56578239
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56237622
23Endometrial cancer_Homo sapiens_hsa052131.52766604
24Cocaine addiction_Homo sapiens_hsa050301.43271802
25Renin secretion_Homo sapiens_hsa049241.40658267
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40649632
27Oxytocin signaling pathway_Homo sapiens_hsa049211.39265262
28GnRH signaling pathway_Homo sapiens_hsa049121.35859345
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31547816
30mTOR signaling pathway_Homo sapiens_hsa041501.30500359
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30445668
32Collecting duct acid secretion_Homo sapiens_hsa049661.29474533
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28548444
34Insulin signaling pathway_Homo sapiens_hsa049101.28168781
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26301260
36Phototransduction_Homo sapiens_hsa047441.25935722
37cAMP signaling pathway_Homo sapiens_hsa040241.25843110
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23676913
39Gap junction_Homo sapiens_hsa045401.17086604
40Axon guidance_Homo sapiens_hsa043601.16595554
41AMPK signaling pathway_Homo sapiens_hsa041521.15899098
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13769081
43Type II diabetes mellitus_Homo sapiens_hsa049301.13224752
44Notch signaling pathway_Homo sapiens_hsa043301.08515149
45Tight junction_Homo sapiens_hsa045301.06272735
46Prolactin signaling pathway_Homo sapiens_hsa049171.05276608
47Non-small cell lung cancer_Homo sapiens_hsa052231.04954644
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04290723
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.04143411
50Adherens junction_Homo sapiens_hsa045201.02530208
51Melanogenesis_Homo sapiens_hsa049161.01383430
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01290729
53Phenylalanine metabolism_Homo sapiens_hsa003601.00658839
54ErbB signaling pathway_Homo sapiens_hsa040121.00529777
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96057865
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95992980
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94051071
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93438165
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89429372
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.89395875
61Chronic myeloid leukemia_Homo sapiens_hsa052200.88348896
62Dorso-ventral axis formation_Homo sapiens_hsa043200.86583997
63Histidine metabolism_Homo sapiens_hsa003400.84764953
64Pancreatic secretion_Homo sapiens_hsa049720.84097330
65Estrogen signaling pathway_Homo sapiens_hsa049150.83380944
66Insulin resistance_Homo sapiens_hsa049310.82690780
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82193189
68Cardiac muscle contraction_Homo sapiens_hsa042600.80944674
69Glioma_Homo sapiens_hsa052140.80780712
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80412027
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.79672549
72Acute myeloid leukemia_Homo sapiens_hsa052210.79527212
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79304374
74Choline metabolism in cancer_Homo sapiens_hsa052310.78851622
75Glucagon signaling pathway_Homo sapiens_hsa049220.78142879
76MAPK signaling pathway_Homo sapiens_hsa040100.77890050
77Pancreatic cancer_Homo sapiens_hsa052120.76781733
78Dilated cardiomyopathy_Homo sapiens_hsa054140.76738976
79Vibrio cholerae infection_Homo sapiens_hsa051100.75459547
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.74432524
81Ras signaling pathway_Homo sapiens_hsa040140.72013265
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.71437766
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71104936
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70070602
85Prostate cancer_Homo sapiens_hsa052150.69972735
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69850333
87Other glycan degradation_Homo sapiens_hsa005110.68833934
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.68777113
89Inositol phosphate metabolism_Homo sapiens_hsa005620.68591802
90Rheumatoid arthritis_Homo sapiens_hsa053230.68416510
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68101040
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67919134
93Sphingolipid metabolism_Homo sapiens_hsa006000.67382591
94* ABC transporters_Homo sapiens_hsa020100.66911511
95Chemokine signaling pathway_Homo sapiens_hsa040620.66715340
96Thyroid cancer_Homo sapiens_hsa052160.66371450
97African trypanosomiasis_Homo sapiens_hsa051430.65563042
98Rap1 signaling pathway_Homo sapiens_hsa040150.65434241
99Wnt signaling pathway_Homo sapiens_hsa043100.64374095
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63594617
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63535882
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62493727
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61598697
104FoxO signaling pathway_Homo sapiens_hsa040680.58970339
105Thyroid hormone synthesis_Homo sapiens_hsa049180.58222973
106Oocyte meiosis_Homo sapiens_hsa041140.56067433
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.54648704
108Focal adhesion_Homo sapiens_hsa045100.53208364
109Ether lipid metabolism_Homo sapiens_hsa005650.53013044
110beta-Alanine metabolism_Homo sapiens_hsa004100.52973391
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52888494
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52717010
113Type I diabetes mellitus_Homo sapiens_hsa049400.52436295
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.52379716
115Salmonella infection_Homo sapiens_hsa051320.51828985
116Alcoholism_Homo sapiens_hsa050340.51293644
117Colorectal cancer_Homo sapiens_hsa052100.51083927
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51083746
119Circadian rhythm_Homo sapiens_hsa047100.50163374
120VEGF signaling pathway_Homo sapiens_hsa043700.49858566
121Platelet activation_Homo sapiens_hsa046110.49765054
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49678256
123Endocytosis_Homo sapiens_hsa041440.48925453
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47373421
125Lysosome_Homo sapiens_hsa041420.47026012
126Tuberculosis_Homo sapiens_hsa051520.46677803
127Ovarian steroidogenesis_Homo sapiens_hsa049130.46035008
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45218934
129Phagosome_Homo sapiens_hsa041450.44949511
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44327423
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43366972
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42594867
133Osteoclast differentiation_Homo sapiens_hsa043800.42534173
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40969438
135Renal cell carcinoma_Homo sapiens_hsa052110.38413124
136B cell receptor signaling pathway_Homo sapiens_hsa046620.35791434

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