ABCC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.83493833
2binding of sperm to zona pellucida (GO:0007339)9.76382989
3plasma membrane fusion (GO:0045026)9.62430811
4male meiosis (GO:0007140)9.60256669
5cell-cell recognition (GO:0009988)9.54914041
6motile cilium assembly (GO:0044458)9.49787493
7spermatid development (GO:0007286)9.01267961
8cell wall macromolecule metabolic process (GO:0044036)8.91822759
9cell wall macromolecule catabolic process (GO:0016998)8.91822759
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.86694284
11cilium movement (GO:0003341)8.85745269
12synaptonemal complex organization (GO:0070193)8.76820835
13reproduction (GO:0000003)8.62485397
14synaptonemal complex assembly (GO:0007130)8.26303901
15regulation of cilium movement (GO:0003352)7.90251340
16single fertilization (GO:0007338)7.15004246
17DNA methylation involved in gamete generation (GO:0043046)7.11571198
18sperm capacitation (GO:0048240)6.66911671
19negative regulation of inclusion body assembly (GO:0090084)6.58789102
20male meiosis I (GO:0007141)6.56246693
21fertilization (GO:0009566)6.30947469
22spermatogenesis (GO:0007283)5.81008420
23male gamete generation (GO:0048232)5.78905368
24chromosome organization involved in meiosis (GO:0070192)5.76106249
25ventricular system development (GO:0021591)5.70148962
26meiotic nuclear division (GO:0007126)5.55466976
27gamete generation (GO:0007276)5.32033268
28meiosis I (GO:0007127)5.30178939
29regulation of inclusion body assembly (GO:0090083)5.26812983
30germ cell development (GO:0007281)5.25586861
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.21129180
32synaptic vesicle docking involved in exocytosis (GO:0016081)5.18786185
33single strand break repair (GO:0000012)5.11321280
34organic cation transport (GO:0015695)5.10083192
35establishment of protein localization to Golgi (GO:0072600)5.05476357
36protein targeting to Golgi (GO:0000042)4.91582519
37seminiferous tubule development (GO:0072520)4.91526780
38meiotic cell cycle (GO:0051321)4.91213743
39regulation of female receptivity (GO:0045924)4.86002760
40calcium ion-dependent exocytosis (GO:0017156)4.75613286
41protein localization to cilium (GO:0061512)4.72164536
42regulation of microtubule-based movement (GO:0060632)4.70140442
43cell recognition (GO:0008037)4.62411000
44microtubule depolymerization (GO:0007019)4.57566329
45left/right pattern formation (GO:0060972)4.54137705
46microtubule polymerization or depolymerization (GO:0031109)4.49456669
47microtubule severing (GO:0051013)4.47140852
48retrograde transport, vesicle recycling within Golgi (GO:0000301)4.45389583
49gonadal mesoderm development (GO:0007506)4.40298849
50response to pheromone (GO:0019236)4.24182677
51gene silencing by RNA (GO:0031047)4.23835993
52phosphatidylethanolamine biosynthetic process (GO:0006646)4.20918475
53genitalia morphogenesis (GO:0035112)4.18077560
54multicellular organismal reproductive process (GO:0048609)4.17929605
55female mating behavior (GO:0060180)4.09528894
56axoneme assembly (GO:0035082)4.08491708
57intraciliary transport (GO:0042073)4.07346711
58C4-dicarboxylate transport (GO:0015740)4.03319739
59protein polyglutamylation (GO:0018095)3.92103710
60phosphatidylethanolamine metabolic process (GO:0046337)3.85464467
61cellular ketone body metabolic process (GO:0046950)3.83609297
62regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73706767
63monoubiquitinated protein deubiquitination (GO:0035520)3.70333194
64negative regulation of organelle assembly (GO:1902116)3.65181367
65positive regulation of meiosis (GO:0045836)3.63616267
66microtubule-based movement (GO:0007018)3.57207253
67synaptic vesicle maturation (GO:0016188)3.56225176
68protein localization to Golgi apparatus (GO:0034067)3.55650595
69chaperone-mediated protein complex assembly (GO:0051131)3.53986432
70regulation of meiosis I (GO:0060631)3.53627139
71carnitine transmembrane transport (GO:1902603)3.53218510
72regulation of Rab GTPase activity (GO:0032313)3.52631348
73positive regulation of Rab GTPase activity (GO:0032851)3.52631348
74amino-acid betaine transport (GO:0015838)3.50658545
75carnitine transport (GO:0015879)3.50658545
76membrane depolarization during action potential (GO:0086010)3.47296226
77spermatid nucleus differentiation (GO:0007289)3.46017589
78meiotic cell cycle process (GO:1903046)3.44365439
79positive regulation of meiotic cell cycle (GO:0051446)3.41725374
80synapsis (GO:0007129)3.40548866
81multicellular organismal development (GO:0007275)3.40068724
82microtubule nucleation (GO:0007020)3.37976665
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36942842
84ketone body metabolic process (GO:1902224)3.30861354
85cilium organization (GO:0044782)3.28885078
86lactate metabolic process (GO:0006089)3.28620214
87regulation of centriole replication (GO:0046599)3.25970805
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.21054829
89synaptic vesicle exocytosis (GO:0016079)3.14279263
90rRNA methylation (GO:0031167)3.11405111
91cilium assembly (GO:0042384)3.10054868
92glycerol ether metabolic process (GO:0006662)3.08588458
93cilium morphogenesis (GO:0060271)3.03653320
94protein localization to synapse (GO:0035418)3.02496328
95response to acidic pH (GO:0010447)3.02463542
96regulation of transcription involved in cell fate commitment (GO:0060850)3.01749613
97postsynaptic membrane organization (GO:0001941)3.01342447
98alditol metabolic process (GO:0019400)3.01166080
99primary amino compound metabolic process (GO:1901160)3.00215436
100protein refolding (GO:0042026)2.98312693
101cellular component assembly involved in morphogenesis (GO:0010927)2.97958338
102chemosensory behavior (GO:0007635)2.97310530
103regulation of protein polyubiquitination (GO:1902914)2.96500225
104multicellular organismal movement (GO:0050879)2.95785087
105musculoskeletal movement (GO:0050881)2.95785087
106regulation of spindle checkpoint (GO:0090231)2.94968068
107neuronal ion channel clustering (GO:0045161)2.93497171
108sexual reproduction (GO:0019953)2.93326476
109chromosome condensation (GO:0030261)2.92699651
110nuclear pore complex assembly (GO:0051292)2.90820495
111glutamate secretion (GO:0014047)2.89716773
112brain morphogenesis (GO:0048854)2.89649397
113cellular response to pH (GO:0071467)2.89127047
114DNA packaging (GO:0006323)2.88967644
115gene silencing (GO:0016458)2.85660172
116peptidyl-glutamic acid modification (GO:0018200)2.84955451
117sodium ion export (GO:0071436)2.84587243
118cellular modified amino acid catabolic process (GO:0042219)2.84071128
119ether metabolic process (GO:0018904)2.83594399
120nucleoside diphosphate phosphorylation (GO:0006165)2.81402992
121positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80563306
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.79234573
123regulation of establishment or maintenance of cell polarity (GO:0032878)2.78567651
124regulation of synaptic vesicle exocytosis (GO:2000300)2.77494696
125centriole replication (GO:0007099)2.77250072
126neuronal action potential propagation (GO:0019227)2.76265552
127acidic amino acid transport (GO:0015800)2.75994030
128polyol catabolic process (GO:0046174)2.73569567
129cerebral cortex neuron differentiation (GO:0021895)2.71530182
130L-glutamate transport (GO:0015813)2.71463955
131negative regulation of sodium ion transport (GO:0010766)2.69745042
132glycerol metabolic process (GO:0006071)2.68556508
133mitotic sister chromatid cohesion (GO:0007064)2.68260628
134glycolytic process (GO:0006096)2.66153645
135centriole assembly (GO:0098534)2.62249081
136negative regulation of DNA repair (GO:0045738)2.61784223
137detection of mechanical stimulus (GO:0050982)2.61599196
138DNA methylation (GO:0006306)2.61039962
139DNA alkylation (GO:0006305)2.61039962
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60548691
141Golgi to endosome transport (GO:0006895)2.60534297
142sex differentiation (GO:0007548)2.56118300
143nucleus organization (GO:0006997)2.53498539
144quaternary ammonium group transport (GO:0015697)2.50546742
145regulation of chromatin binding (GO:0035561)2.43993335
146protein K11-linked deubiquitination (GO:0035871)2.41178924
147cilium or flagellum-dependent cell motility (GO:0001539)16.1628352
148fusion of sperm to egg plasma membrane (GO:0007342)12.6785210
149sperm motility (GO:0030317)11.8484971
150piRNA metabolic process (GO:0034587)11.3771530
151axonemal dynein complex assembly (GO:0070286)11.1755478
152sperm-egg recognition (GO:0035036)10.6952307
153acrosome assembly (GO:0001675)10.5802562
154multicellular organism reproduction (GO:0032504)10.5342002
155acrosome reaction (GO:0007340)10.2361973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81578956
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.75379165
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.30403818
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.27487037
5* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08739954
6DROSHA_22980978_ChIP-Seq_HELA_Human2.47872838
7GBX2_23144817_ChIP-Seq_PC3_Human2.44415817
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.36070196
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30979978
10ZNF274_21170338_ChIP-Seq_K562_Hela2.26324350
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23329478
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.11036206
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.09783922
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09400321
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.07716987
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05249027
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00161615
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2257318
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.96898642
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89708301
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88520014
22VDR_22108803_ChIP-Seq_LS180_Human1.70448414
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.65721809
24ER_23166858_ChIP-Seq_MCF-7_Human1.64518137
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62824077
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60210313
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.55533897
28AR_21572438_ChIP-Seq_LNCaP_Human1.55280221
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54605175
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54442902
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.53905197
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51088801
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48932112
34STAT1_17558387_ChIP-Seq_HELA_Human1.48654302
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48514784
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47756694
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.44931204
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43334495
39* STAT3_23295773_ChIP-Seq_U87_Human1.42650730
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.41831112
41TAF15_26573619_Chip-Seq_HEK293_Human1.40347204
42AR_25329375_ChIP-Seq_VCAP_Human1.40288558
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39749447
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39454294
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39302801
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.38908095
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38687988
48CBP_20019798_ChIP-Seq_JUKART_Human1.38342113
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38342113
50CTCF_27219007_Chip-Seq_Bcells_Human1.37700940
51FUS_26573619_Chip-Seq_HEK293_Human1.36762426
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.36139535
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35137640
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.34889981
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33872398
56MYC_19829295_ChIP-Seq_ESCs_Human1.33449167
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33418940
58ERA_21632823_ChIP-Seq_H3396_Human1.32738836
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32699049
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32696728
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31791408
62P300_19829295_ChIP-Seq_ESCs_Human1.31791295
63SMAD4_21799915_ChIP-Seq_A2780_Human1.31399205
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29214851
65KDM2B_26808549_Chip-Seq_REH_Human1.29033036
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.28867716
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28837124
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28319246
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28024165
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27138931
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.27010166
72OCT4_20526341_ChIP-Seq_ESCs_Human1.26274819
73* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25992095
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24097279
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23606510
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23606510
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22997704
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.21868580
79TAF2_19829295_ChIP-Seq_ESCs_Human1.21514698
80HOXB7_26014856_ChIP-Seq_BT474_Human1.21141961
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20432587
82* RARB_27405468_Chip-Seq_BRAIN_Mouse1.20331463
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.17363915
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16784458
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16784458
86SMC4_20622854_ChIP-Seq_HELA_Human1.16227188
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16221069
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15246898
89* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13789202
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.13100313
91CTCF_20526341_ChIP-Seq_ESCs_Human1.12601049
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11656871
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10945457
94RUNX2_22187159_ChIP-Seq_PCA_Human1.10922158
95RAC3_21632823_ChIP-Seq_H3396_Human1.10729770
96E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10586938
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10522208
98FOXH1_21741376_ChIP-Seq_EPCs_Human1.10370694
99* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10248673
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09726277
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09543608
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.09173079
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08847633
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08602362
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08191058
106P53_21459846_ChIP-Seq_SAOS-2_Human1.07852722
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07837257
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07374263
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.07369575
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06791758
111* SMAD3_21741376_ChIP-Seq_ESCs_Human1.06572048
112GATA3_21867929_ChIP-Seq_TH1_Mouse1.06442893
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.06211807
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05160775
115RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04777854
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.04586736
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03092862
118* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02501860
119OCT1_27270436_Chip-Seq_PROSTATE_Human1.02424480
120* GF1_26923725_Chip-Seq_HPCs_Mouse1.02403625
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01575539
122EZH2_27304074_Chip-Seq_ESCs_Mouse1.01507109
123P53_22387025_ChIP-Seq_ESCs_Mouse1.00266842
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00060398
125* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99833122
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98958971
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98586278
128P300_18555785_Chip-Seq_ESCs_Mouse0.98467457
129KLF4_18555785_Chip-Seq_ESCs_Mouse0.97826017
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.97115178
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96979198
132BCAT_22108803_ChIP-Seq_LS180_Human0.96473898
133ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96337633
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96221631
135NANOG_20526341_ChIP-Seq_ESCs_Human0.96220820
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95061109
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95018917
138AR_19668381_ChIP-Seq_PC3_Human0.94897074
139RNF2_27304074_Chip-Seq_NSC_Mouse0.94857210
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94828417
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.94683060
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94309897
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94200092
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.93903138
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93738762
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93341156
147P68_20966046_ChIP-Seq_HELA_Human0.93202920
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92820069
149MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92684297
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.92306966
151ERG_20517297_ChIP-Seq_VCAP_Human0.92248856
152TP63_22573176_ChIP-Seq_HFKS_Human0.91517274
153OCT4_19829295_ChIP-Seq_ESCs_Human0.91460228
154NCOR_22424771_ChIP-Seq_293T_Human0.91424102
155RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91406797
156* TCF4_23295773_ChIP-Seq_U87_Human0.90634893
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.90566745
158IGF1R_20145208_ChIP-Seq_DFB_Human0.90522473
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.90256499
160SPI1_26923725_Chip-Seq_HPCs_Mouse0.90253602
161P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89875961
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89648032
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88533723
164RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88476196
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88068516
166PU1_27457419_Chip-Seq_LIVER_Mouse0.87844401
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87691052
168SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85357745
169SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84990008
170* SMAD4_21741376_ChIP-Seq_EPCs_Human0.84958825
171NFYB_21822215_ChIP-Seq_K562_Human0.84169520
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.83859992
173RARA_24833708_ChIP-Seq_LIVER_Mouse0.83848172
174RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83467954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.96127386
2MP0001929_abnormal_gametogenesis5.46250908
3MP0008877_abnormal_DNA_methylation5.36689627
4MP0003880_abnormal_central_pattern4.46403427
5MP0002210_abnormal_sex_determination3.85352379
6MP0002653_abnormal_ependyma_morphology3.80028894
7MP0004859_abnormal_synaptic_plasticity3.79570478
8MP0001145_abnormal_male_reproductive3.23781639
9MP0002161_abnormal_fertility/fecundity3.23452141
10MP0001968_abnormal_touch/_nociception3.20568049
11MP0000653_abnormal_sex_gland2.80946931
12MP0009745_abnormal_behavioral_response2.56885690
13MP0002736_abnormal_nociception_after2.47441268
14MP0005623_abnormal_meninges_morphology2.46459964
15MP0002272_abnormal_nervous_system2.30676961
16MP0002734_abnormal_mechanical_nocicepti2.24605563
17MP0008872_abnormal_physiological_respon2.12007324
18MP0002735_abnormal_chemical_nociception2.05241775
19MP0002064_seizures2.03050715
20MP0002160_abnormal_reproductive_system2.02362388
21MP0005410_abnormal_fertilization14.8465121
22MP0005670_abnormal_white_adipose1.76466435
23MP0009053_abnormal_anal_canal1.75701936
24MP0002063_abnormal_learning/memory/cond1.74115390
25MP0002067_abnormal_sensory_capabilities1.71318258
26MP0009046_muscle_twitch1.70642220
27MP0001501_abnormal_sleep_pattern1.70095707
28MP0010368_abnormal_lymphatic_system1.65772587
29MP0006276_abnormal_autonomic_nervous1.62035136
30MP0001970_abnormal_pain_threshold1.43981797
31MP0008057_abnormal_DNA_replication1.42941993
32MP0002282_abnormal_trachea_morphology1.37824901
33MP0003011_delayed_dark_adaptation1.31660915
34MP0001984_abnormal_olfaction1.30548471
35MP0005379_endocrine/exocrine_gland_phen1.28814863
36MP0001485_abnormal_pinna_reflex1.26512410
37MP0001348_abnormal_lacrimal_gland1.24672027
38MP0000538_abnormal_urinary_bladder1.22097575
39MP0002733_abnormal_thermal_nociception1.18642298
40MP0003646_muscle_fatigue1.17462484
41MP0004084_abnormal_cardiac_muscle1.17301982
42MP0003119_abnormal_digestive_system1.16648845
43MP0004742_abnormal_vestibular_system1.16288560
44MP0005647_abnormal_sex_gland1.15780643
45MP0001666_abnormal_nutrient_absorption1.13486607
46MP0004924_abnormal_behavior1.12374186
47MP0005386_behavior/neurological_phenoty1.12374186
48MP0004145_abnormal_muscle_electrophysio1.10821527
49MP0001963_abnormal_hearing_physiology1.09320214
50MP0005083_abnormal_biliary_tract1.09219785
51MP0004233_abnormal_muscle_weight1.08232853
52MP0000579_abnormal_nail_morphology1.07386539
53MP0002822_catalepsy1.06684957
54MP0003136_yellow_coat_color1.06237867
55MP0001765_abnormal_ion_homeostasis1.05028581
56MP0008058_abnormal_DNA_repair1.03186258
57MP0001177_atelectasis1.00823233
58MP0004147_increased_porphyrin_level0.99254033
59MP0000751_myopathy0.99157839
60MP0003718_maternal_effect0.95570469
61MP0008995_early_reproductive_senescence0.95566878
62MP0001664_abnormal_digestion0.95052003
63MP0005389_reproductive_system_phenotype0.95025673
64MP0005310_abnormal_salivary_gland0.94034519
65MP0009780_abnormal_chondrocyte_physiolo0.92482563
66MP0010329_abnormal_lipoprotein_level0.91708298
67MP0004085_abnormal_heartbeat0.90367158
68MP0002882_abnormal_neuron_morphology0.88385443
69MP0010094_abnormal_chromosome_stability0.85134820
70MP0002066_abnormal_motor_capabilities/c0.84787619
71MP0003878_abnormal_ear_physiology0.82110572
72MP0005377_hearing/vestibular/ear_phenot0.82110572
73MP0000026_abnormal_inner_ear0.82087770
74MP0002184_abnormal_innervation0.77097237
75MP0000569_abnormal_digit_pigmentation0.76705625
76MP0002638_abnormal_pupillary_reflex0.75306745
77MP0003329_amyloid_beta_deposits0.75170407
78MP0008007_abnormal_cellular_replicative0.73015086
79MP0003137_abnormal_impulse_conducting0.72966730
80MP0003868_abnormal_feces_composition0.71736029
81MP0009278_abnormal_bone_marrow0.71322862
82MP0001905_abnormal_dopamine_level0.71181364
83MP0001346_abnormal_lacrimal_gland0.70982628
84MP0008874_decreased_physiological_sensi0.69498033
85MP0003786_premature_aging0.68739086
86MP0005248_abnormal_Harderian_gland0.65462399
87MP0008004_abnormal_stomach_pH0.64598829
88MP0000358_abnormal_cell_content/0.63680756
89MP0008775_abnormal_heart_ventricle0.63079115
90MP0002132_abnormal_respiratory_system0.62338545
91MP0003638_abnormal_response/metabolism_0.61524141
92MP0003115_abnormal_respiratory_system0.60645380
93MP0002234_abnormal_pharynx_morphology0.59547536
94MP0003950_abnormal_plasma_membrane0.59280610
95MP0002928_abnormal_bile_duct0.57092123
96MP0004019_abnormal_vitamin_homeostasis0.55873849
97MP0003699_abnormal_female_reproductive0.53651529
98MP0008961_abnormal_basal_metabolism0.53140653
99MP0004134_abnormal_chest_morphology0.50949796
100MP0005551_abnormal_eye_electrophysiolog0.50942317
101MP0005253_abnormal_eye_physiology0.50785057
102MP0005636_abnormal_mineral_homeostasis0.50309439
103MP0001545_abnormal_hematopoietic_system0.47870647
104MP0005397_hematopoietic_system_phenotyp0.47870647
105MP0003183_abnormal_peptide_metabolism0.47265311
106MP0004808_abnormal_hematopoietic_stem0.47033591
107MP0003879_abnormal_hair_cell0.46857851
108MP0000427_abnormal_hair_cycle0.46422394
109MP0003045_fibrosis0.44907342
110MP0001293_anophthalmia0.44433077
111MP0003633_abnormal_nervous_system0.44076363
112MP0002971_abnormal_brown_adipose0.43461710
113MP0005391_vision/eye_phenotype0.42016711
114MP0002269_muscular_atrophy0.40777967
115MP0001661_extended_life_span0.40117401
116MP0002139_abnormal_hepatobiliary_system0.38602328
117MP0001119_abnormal_female_reproductive0.37842896
118MP0005365_abnormal_bile_salt0.36556606
119MP0002152_abnormal_brain_morphology0.36530901
120MP0010307_abnormal_tumor_latency0.36139959
121MP0003631_nervous_system_phenotype0.35867984
122MP0005666_abnormal_adipose_tissue0.35852202
123MP0003861_abnormal_nervous_system0.35689151
124MP0001324_abnormal_eye_pigmentation0.34235310
125MP0004811_abnormal_neuron_physiology0.34004117
126MP0004270_analgesia0.31199942
127MP0000604_amyloidosis0.31148580
128MP0000647_abnormal_sebaceous_gland0.30251148
129MP0001440_abnormal_grooming_behavior0.29888451
130MP0002102_abnormal_ear_morphology0.28726963
131MP0001764_abnormal_homeostasis0.28395458
132MP0003252_abnormal_bile_duct0.28026557
133MP0002092_abnormal_eye_morphology0.27651842
134MP0003111_abnormal_nucleus_morphology0.27171904
135MP0002572_abnormal_emotion/affect_behav0.27101546
136MP0004133_heterotaxia0.26486630
137MP0008569_lethality_at_weaning0.25779348
138MP0004036_abnormal_muscle_relaxation0.25684217
139MP0009115_abnormal_fat_cell0.25097674
140MP0000955_abnormal_spinal_cord0.24406509
141MP0005423_abnormal_somatic_nervous0.24022164
142MP0000534_abnormal_ureter_morphology0.23408548
143MP0003634_abnormal_glial_cell0.23396962
144MP0003942_abnormal_urinary_system0.23042729
145MP0001730_embryonic_growth_arrest0.22827778
146MP0002557_abnormal_social/conspecific_i0.22628190
147MP0001486_abnormal_startle_reflex0.22487339
148MP0002229_neurodegeneration0.21960663
149MP0003632_abnormal_nervous_system0.21784722
150MP0001851_eye_inflammation0.21563746
151MP0003635_abnormal_synaptic_transmissio0.21228373
152MP0002909_abnormal_adrenal_gland0.21185867
153MP0003959_abnormal_lean_body0.20229324
154MP0001986_abnormal_taste_sensitivity0.19598279
155MP0002084_abnormal_developmental_patter0.19280490
156MP0005646_abnormal_pituitary_gland0.17752311
157MP0003936_abnormal_reproductive_system0.17674370
158MP0001727_abnormal_embryo_implantation0.17507802

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39917204
2Abnormal respiratory motile cilium morphology (HP:0005938)8.67964402
3Abnormal respiratory epithelium morphology (HP:0012253)8.67964402
4Rhinitis (HP:0012384)8.11150126
5Abnormal ciliary motility (HP:0012262)7.55959989
6Chronic bronchitis (HP:0004469)7.11174310
7Nasal polyposis (HP:0100582)6.34383744
8Infertility (HP:0000789)6.10903507
9Abnormality of the nasal mucosa (HP:0000433)5.20805878
10Chronic hepatic failure (HP:0100626)4.85205102
11Myokymia (HP:0002411)4.81022551
12Bronchiectasis (HP:0002110)4.68770962
13Nephronophthisis (HP:0000090)4.65199648
14Atonic seizures (HP:0010819)4.55335927
15Severe visual impairment (HP:0001141)4.42497043
16Abnormality of macular pigmentation (HP:0008002)4.41198288
17Bronchitis (HP:0012387)4.40937476
18Abnormality of the lower motor neuron (HP:0002366)4.06683640
19Hyperkalemia (HP:0002153)4.01492215
20Ependymoma (HP:0002888)3.87995014
21Asymmetric septal hypertrophy (HP:0001670)3.81227676
22Progressive cerebellar ataxia (HP:0002073)3.75387154
23Abnormality of the renal medulla (HP:0100957)3.55438930
24Attenuation of retinal blood vessels (HP:0007843)3.39193671
25Bony spicule pigmentary retinopathy (HP:0007737)3.38919363
26Hyperglycinuria (HP:0003108)3.35362917
27Focal motor seizures (HP:0011153)3.34465908
28Recurrent otitis media (HP:0000403)3.28757937
29Male infertility (HP:0003251)3.25565963
30Focal seizures (HP:0007359)3.23969914
31Febrile seizures (HP:0002373)3.14173198
32Recurrent sinusitis (HP:0011108)3.14034957
33Postural instability (HP:0002172)3.10851287
34Amyotrophic lateral sclerosis (HP:0007354)3.09805586
35Gonadotropin excess (HP:0000837)3.05543224
36Tubulointerstitial nephritis (HP:0001970)2.99041948
37Potter facies (HP:0002009)2.97045328
38Facial shape deformation (HP:0011334)2.97045328
39Inability to walk (HP:0002540)2.87144369
40Hypoalphalipoproteinemia (HP:0003233)2.86622248
41Horizontal nystagmus (HP:0000666)2.85453269
42Absence seizures (HP:0002121)2.84164887
43Abnormality of the astrocytes (HP:0100707)2.81683449
44Astrocytoma (HP:0009592)2.81683449
45Cone-rod dystrophy (HP:0000548)2.81256631
46Fibular hypoplasia (HP:0003038)2.79093271
47Abnormal spermatogenesis (HP:0008669)2.75496213
48Molar tooth sign on MRI (HP:0002419)2.64202174
49Abnormality of midbrain morphology (HP:0002418)2.64202174
50Tubular atrophy (HP:0000092)2.63390993
51Amelogenesis imperfecta (HP:0000705)2.62691928
52Status epilepticus (HP:0002133)2.61820133
53Recurrent bronchitis (HP:0002837)2.60779587
54Medial flaring of the eyebrow (HP:0010747)2.55557666
55Action tremor (HP:0002345)2.52844860
56Dialeptic seizures (HP:0011146)2.52508155
57Tubulointerstitial abnormality (HP:0001969)2.50354833
58Abnormality of binocular vision (HP:0011514)2.43920835
59Diplopia (HP:0000651)2.43920835
60Epileptic encephalopathy (HP:0200134)2.42636405
61Impaired proprioception (HP:0010831)2.40669646
62Neoplasm of the heart (HP:0100544)2.39426379
63Resting tremor (HP:0002322)2.38000810
64Hypoplastic ischia (HP:0003175)2.37286931
65Enlarged epiphyses (HP:0010580)2.33578424
66Abnormality of dental color (HP:0011073)2.32776024
67Postaxial foot polydactyly (HP:0001830)2.28449845
68Spontaneous abortion (HP:0005268)2.27912664
69Abnormality of serine family amino acid metabolism (HP:0010894)2.26702021
70Abnormality of glycine metabolism (HP:0010895)2.26702021
71Upper motor neuron abnormality (HP:0002127)2.25245621
72Impulsivity (HP:0100710)2.23488010
73Azoospermia (HP:0000027)2.22625970
74Glioma (HP:0009733)2.22214605
75Retinal dysplasia (HP:0007973)2.15204708
76Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13253860
77Abnormality of the ischium (HP:0003174)2.12853683
78Abnormality of the costochondral junction (HP:0000919)2.10896880
79Stage 5 chronic kidney disease (HP:0003774)2.10331767
80Osteomalacia (HP:0002749)2.08192738
81Type II lissencephaly (HP:0007260)2.07047998
82Congenital hepatic fibrosis (HP:0002612)2.06247199
83Abnormality of potassium homeostasis (HP:0011042)2.02735440
84Insulin-resistant diabetes mellitus (HP:0000831)2.01884336
85Hyperventilation (HP:0002883)2.00498600
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5765479
87Dynein arm defect of respiratory motile cilia (HP:0012255)12.1794157
88Absent/shortened dynein arms (HP:0200106)12.1794157
89Degeneration of anterior horn cells (HP:0002398)1.99545511
90Abnormality of the anterior horn cell (HP:0006802)1.99545511
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97509562
92Tubulointerstitial fibrosis (HP:0005576)1.96539318
93Intellectual disability, moderate (HP:0002342)1.96532019
94Genital tract atresia (HP:0001827)1.92449419
95Truncal obesity (HP:0001956)1.91240997
96Short ribs (HP:0000773)1.90484566
97Spastic tetraparesis (HP:0001285)1.90058136
98Abnormality of the renal cortex (HP:0011035)1.89992174
99Muscle hypertrophy of the lower extremities (HP:0008968)1.88675569
100Abnormal drinking behavior (HP:0030082)1.88148791
101Polydipsia (HP:0001959)1.88148791
102Scotoma (HP:0000575)1.87675055
103Renal dysplasia (HP:0000110)1.86692271
104Supernumerary spleens (HP:0009799)1.86256962
105Microglossia (HP:0000171)1.85997191
106Oculomotor apraxia (HP:0000657)1.84673948
107Chronic sinusitis (HP:0011109)1.82632896
108Abnormality of proline metabolism (HP:0010907)1.82433973
109Hydroxyprolinuria (HP:0003080)1.82433973
110Vaginal atresia (HP:0000148)1.80957146
111Absent frontal sinuses (HP:0002688)1.80018768
112Decreased circulating renin level (HP:0003351)1.79536825
113Abnormality of dentin (HP:0010299)1.79381096
114Abnormality of the dental root (HP:0006486)1.79131884
115Taurodontia (HP:0000679)1.79131884
116Abnormality of permanent molar morphology (HP:0011071)1.79131884
117Decreased central vision (HP:0007663)1.78878770
118Polyuria (HP:0000103)1.78771741
119Hemiplegia (HP:0002301)1.78337682
120J-shaped sella turcica (HP:0002680)1.77747742
121Concave nail (HP:0001598)1.77496947
122Impaired vibration sensation in the lower limbs (HP:0002166)1.76290819
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.75721572
124Generalized tonic-clonic seizures (HP:0002069)1.75341576
125Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75299448
126Hyponatremia (HP:0002902)1.74057335
127Calf muscle hypertrophy (HP:0008981)1.72659432
128Abnormal rod and cone electroretinograms (HP:0008323)1.72550769
129Postaxial hand polydactyly (HP:0001162)1.71028472
130Facial cleft (HP:0002006)1.71026515
131Bundle branch block (HP:0011710)1.70676792
132Pancreatic cysts (HP:0001737)1.70648481
13311 pairs of ribs (HP:0000878)1.70395565
134Dysdiadochokinesis (HP:0002075)1.70254378
135Abnormality of the dental pulp (HP:0006479)1.68334424
136Heterotopia (HP:0002282)1.68124616
137Abnormality of molar (HP:0011077)1.67888655
138Abnormality of molar morphology (HP:0011070)1.67888655
139Median cleft lip (HP:0000161)1.67739188
140Abnormality of ocular smooth pursuit (HP:0000617)1.64837061
141Bell-shaped thorax (HP:0001591)1.64578001
142Absent epiphyses (HP:0010577)1.59213659
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59213659
144Short thorax (HP:0010306)1.57366174
145Cystic liver disease (HP:0006706)1.56761310
146Cholecystitis (HP:0001082)1.56560772
147Abnormal gallbladder physiology (HP:0012438)1.56560772
148Bile duct proliferation (HP:0001408)1.53935878
149Abnormal biliary tract physiology (HP:0012439)1.53935878
150Abnormality of renal excretion (HP:0011036)1.53471958
151Gaze-evoked nystagmus (HP:0000640)1.50836824
152Congenital primary aphakia (HP:0007707)1.47989149
153Gait imbalance (HP:0002141)1.47460914
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.45432661
155Nephropathy (HP:0000112)1.45355949
156Deformed sella turcica (HP:0002681)1.44731445
157Hemiparesis (HP:0001269)1.44467479
158Pancreatic fibrosis (HP:0100732)1.41676773
159Conjunctival telangiectasia (HP:0000524)1.40984618
160Decreased motor nerve conduction velocity (HP:0003431)1.36807247
161Neurofibrillary tangles (HP:0002185)1.33231237
162Broad distal phalanx of finger (HP:0009836)1.32150330
163Pachygyria (HP:0001302)1.31458036
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.28970628
165Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.27157983
166Abnormal urine output (HP:0012590)1.26185879
167Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.24862406
168Breast carcinoma (HP:0003002)1.24479257
169Aplasia/Hypoplasia of the lens (HP:0008063)1.24306523
170Selective tooth agenesis (HP:0001592)1.24224643
171Nephrogenic diabetes insipidus (HP:0009806)1.23617309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.85167734
2PDK48.85167734
3PDK25.75403728
4INSRR4.72224282
5TESK14.62100888
6PRKD34.16130837
7ICK3.28597911
8EPHA43.12167946
9NTRK33.07695627
10FRK2.74544307
11PLK22.63548550
12PNCK2.54646098
13WNK42.52409345
14PTK2B2.47543610
15STK392.32869849
16CDK192.29525841
17DAPK22.29000906
18ACVR1B2.00710899
19MAPK151.84555719
20MAP3K131.79583425
21NEK21.77663663
22MST1R1.72826069
23MATK1.72073827
24TNK21.62963005
25ERBB41.62322886
26MAP3K91.54985381
27STK381.51121678
28CASK1.49943105
29MARK11.34946681
30WNK11.32568816
31BRD41.31290616
32PHKG11.14258887
33PHKG21.14258887
34DYRK1B1.09338165
35CAMK11.05789975
36OBSCN1.02848745
37PRKG21.02149908
38TYRO31.01805975
39PRKCI1.00214642
40STK30.94776682
41MAP4K20.87516358
42PKN10.87041632
43KSR20.86569373
44PDK10.86565316
45LATS20.85741652
46FER0.85198372
47ERBB20.84012120
48CCNB10.78698108
49MET0.76876752
50CDK70.76788609
51CDC70.73093373
52PASK0.72317248
53CDK50.71919450
54FGFR40.71447614
55LMTK20.71159761
56PINK10.70776790
57SGK10.68594708
58OXSR10.68229614
59MAP3K70.67280422
60SIK20.65977800
61NME10.65478499
62IRAK10.61856071
63PIK3CA0.58779550
64ARAF0.58312515
65DYRK30.57658593
66TTK0.57209346
67CAMK1G0.57165058
68WEE10.50767175
69WNK30.49308099
70MINK10.48166251
71CHEK10.45472335
72ATR0.44945782
73DAPK10.43997169
74PRKCE0.43851682
75PBK0.42762976
76UHMK10.42284731
77CHEK20.41683169
78ALK0.40682607
79GRK50.40562284
80CAMKK10.40380856
81NTRK20.39995318
82CAMK2G0.39834958
83TESK20.39294938
84PRKACA0.38665517
85MTOR0.36717483
86EEF2K0.35820327
87RIPK10.35525408
88RPS6KA20.35318746
89PRKCH0.34807687
90MAPK110.34443217
91PAK30.33996596
92PDPK10.32926995
93MAP3K110.30942215
94PRKCG0.30797993
95ATM0.30501747
96JAK20.29796359
97PRKAA20.29685191
98PRKAA10.27045125
99PIK3CG0.26773597
100PAK20.26480059
101BMPR1B0.26185525
102CDK120.25292887
103PLK40.24048356
104NEK60.23767757
105MUSK0.22938391
106STK38L0.22855876
107PAK10.21441059
108PAK60.21236826
109IRAK20.18969240
110MAP2K60.18814493
111MAPKAPK50.18195965
112MARK20.17423448
113PLK10.16318577
114RPS6KB10.15768736
115RIPK40.15288048
116BRSK20.11755191
117MAP3K40.10612144
118PRKCZ0.08588864
119PDGFRB0.06945290
120CDK30.06784271
121STK110.06680216
122TRIB30.06167624
123GSK3B0.05835804
124PRKDC0.05572040
125PRKACB0.05542239
126YES10.05294062
127CDK10.05178502
128EPHB10.05075619
129MAPK80.04926011
130PRKACG0.04403969
131PTK60.04031120
132RPS6KA30.03850033
133CDK150.03489068
134CSNK1D0.03341126
135PRKG10.03278577
136CDK20.02352400
137MAPK100.01784431
138CSK0.01672178
139RPS6KA10.01593603
140PRKCB0.01180792
141MARK30.00932651
142CDK180.00923408
143PRKCQ0.00874577
144CDK11A0.00375185
145EGFR0.00232107
146TAOK10.00072460
147DDR20.00033417
148CAMK2A-0.0279174
149MAPK1-0.0266404
150SRC-0.0258480
151CDK14-0.0233450
152PRKCA-0.0173330
153PAK4-0.0161666
154CSNK2A1-0.0158289
155LATS1-0.0107079
156BRSK1-0.0057312

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.78935203
2Pyruvate metabolism_Homo sapiens_hsa006203.95747039
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.84975008
4Fatty acid biosynthesis_Homo sapiens_hsa000613.33922956
5Dorso-ventral axis formation_Homo sapiens_hsa043203.21943294
6Propanoate metabolism_Homo sapiens_hsa006403.10729311
7Nicotine addiction_Homo sapiens_hsa050332.88618114
8Glucagon signaling pathway_Homo sapiens_hsa049222.84704482
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73091358
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57872793
11Selenocompound metabolism_Homo sapiens_hsa004502.54274527
12Pentose phosphate pathway_Homo sapiens_hsa000302.52048893
13Linoleic acid metabolism_Homo sapiens_hsa005912.39234409
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.29788306
15Basal transcription factors_Homo sapiens_hsa030222.25401077
16Fanconi anemia pathway_Homo sapiens_hsa034602.20126141
17Glycerolipid metabolism_Homo sapiens_hsa005612.05450471
18Butanoate metabolism_Homo sapiens_hsa006502.05202824
19* ABC transporters_Homo sapiens_hsa020101.96969149
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95754658
21Oocyte meiosis_Homo sapiens_hsa041141.85569945
22Amphetamine addiction_Homo sapiens_hsa050311.76628232
23PPAR signaling pathway_Homo sapiens_hsa033201.76097751
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75586548
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69869181
26Morphine addiction_Homo sapiens_hsa050321.66944499
27Arginine and proline metabolism_Homo sapiens_hsa003301.61782607
28Huntingtons disease_Homo sapiens_hsa050161.61004108
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60101752
30beta-Alanine metabolism_Homo sapiens_hsa004101.50872402
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.50789778
32GABAergic synapse_Homo sapiens_hsa047271.50402183
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.47695820
34Fructose and mannose metabolism_Homo sapiens_hsa000511.46852414
35Renin secretion_Homo sapiens_hsa049241.36716707
36Carbon metabolism_Homo sapiens_hsa012001.34878725
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31858010
38Phototransduction_Homo sapiens_hsa047441.31650451
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29700761
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28593782
41Histidine metabolism_Homo sapiens_hsa003401.28051798
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21242865
43Fatty acid metabolism_Homo sapiens_hsa012121.20928076
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.19021027
45Cholinergic synapse_Homo sapiens_hsa047251.15444434
46mRNA surveillance pathway_Homo sapiens_hsa030151.13853106
47Fat digestion and absorption_Homo sapiens_hsa049751.13654019
48Nitrogen metabolism_Homo sapiens_hsa009101.12081919
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10821893
50Long-term potentiation_Homo sapiens_hsa047201.10043576
51Fatty acid degradation_Homo sapiens_hsa000711.09653706
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07815646
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04874397
54Ether lipid metabolism_Homo sapiens_hsa005651.02740636
55Phenylalanine metabolism_Homo sapiens_hsa003601.00518389
56Cardiac muscle contraction_Homo sapiens_hsa042601.00218725
57Oxytocin signaling pathway_Homo sapiens_hsa049210.98836041
58Antigen processing and presentation_Homo sapiens_hsa046120.95826366
59Serotonergic synapse_Homo sapiens_hsa047260.95816168
60Biosynthesis of amino acids_Homo sapiens_hsa012300.93354929
61Estrogen signaling pathway_Homo sapiens_hsa049150.90939616
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85692433
63Mineral absorption_Homo sapiens_hsa049780.85088107
64Fatty acid elongation_Homo sapiens_hsa000620.84149376
65Collecting duct acid secretion_Homo sapiens_hsa049660.83840224
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81683823
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80265719
68Insulin secretion_Homo sapiens_hsa049110.79052146
69RNA transport_Homo sapiens_hsa030130.78126257
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76790891
71Long-term depression_Homo sapiens_hsa047300.75855382
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72636602
73Calcium signaling pathway_Homo sapiens_hsa040200.69263668
74Arginine biosynthesis_Homo sapiens_hsa002200.68323153
75N-Glycan biosynthesis_Homo sapiens_hsa005100.68284576
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68025330
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66790059
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65671252
79Choline metabolism in cancer_Homo sapiens_hsa052310.65575431
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.64975059
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64955862
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64913551
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64378881
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.63589865
85Bile secretion_Homo sapiens_hsa049760.63354217
86Taste transduction_Homo sapiens_hsa047420.62114932
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61240570
88Purine metabolism_Homo sapiens_hsa002300.61093741
89Hedgehog signaling pathway_Homo sapiens_hsa043400.60828516
90Chemical carcinogenesis_Homo sapiens_hsa052040.59185989
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56976358
92Circadian entrainment_Homo sapiens_hsa047130.56154818
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.55391038
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.53521549
95Tyrosine metabolism_Homo sapiens_hsa003500.52616613
96AMPK signaling pathway_Homo sapiens_hsa041520.52476741
97Thyroid hormone synthesis_Homo sapiens_hsa049180.52397318
98Circadian rhythm_Homo sapiens_hsa047100.52065332
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48711718
100ErbB signaling pathway_Homo sapiens_hsa040120.48243901
101Inositol phosphate metabolism_Homo sapiens_hsa005620.48119762
102Tryptophan metabolism_Homo sapiens_hsa003800.48017521
103Glutamatergic synapse_Homo sapiens_hsa047240.47480104
104Gastric acid secretion_Homo sapiens_hsa049710.47111715
105VEGF signaling pathway_Homo sapiens_hsa043700.46162617
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45765938
107Glutathione metabolism_Homo sapiens_hsa004800.45205362
108Pancreatic secretion_Homo sapiens_hsa049720.43274869
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42560645
110Glioma_Homo sapiens_hsa052140.42326957
111Retinol metabolism_Homo sapiens_hsa008300.41759511
112Arachidonic acid metabolism_Homo sapiens_hsa005900.41610893
113Legionellosis_Homo sapiens_hsa051340.41206922
114Endocytosis_Homo sapiens_hsa041440.40581920
115Salivary secretion_Homo sapiens_hsa049700.40082737
116Tight junction_Homo sapiens_hsa045300.40013482
117Dilated cardiomyopathy_Homo sapiens_hsa054140.39100243
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.37463598
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.36847614
120Peroxisome_Homo sapiens_hsa041460.36037425
121Protein digestion and absorption_Homo sapiens_hsa049740.35128352
122Synaptic vesicle cycle_Homo sapiens_hsa047210.34780069
123MAPK signaling pathway_Homo sapiens_hsa040100.34374009
124Systemic lupus erythematosus_Homo sapiens_hsa053220.33939740
125cAMP signaling pathway_Homo sapiens_hsa040240.33640414
126mTOR signaling pathway_Homo sapiens_hsa041500.33360089
127Olfactory transduction_Homo sapiens_hsa047400.31630274
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31520391
129Sulfur relay system_Homo sapiens_hsa041220.30608947
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30477440
131Melanogenesis_Homo sapiens_hsa049160.30389834
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29655998
133Renin-angiotensin system_Homo sapiens_hsa046140.29333612
134Cocaine addiction_Homo sapiens_hsa050300.28819613
135Metabolic pathways_Homo sapiens_hsa011000.26763597
136Wnt signaling pathway_Homo sapiens_hsa043100.26654334
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21533721
138Sphingolipid metabolism_Homo sapiens_hsa006000.21189007
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21162312
140Alcoholism_Homo sapiens_hsa050340.20644340
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20511780
142Basal cell carcinoma_Homo sapiens_hsa052170.19613768
143Dopaminergic synapse_Homo sapiens_hsa047280.19295391
144Type II diabetes mellitus_Homo sapiens_hsa049300.18941944

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