ABCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62890309
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62890309
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.62890309
4modulation by symbiont of host immune response (GO:0052553)5.62890309
5positive regulation by symbiont of host defense response (GO:0052509)5.62890309
6modulation by symbiont of host defense response (GO:0052031)5.62890309
7response to peptidoglycan (GO:0032494)4.26611194
8regulation of dendritic cell antigen processing and presentation (GO:0002604)3.98318145
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94711898
10response to host immune response (GO:0052572)3.94711898
11negative regulation of erythrocyte differentiation (GO:0045647)3.91504076
12response to muramyl dipeptide (GO:0032495)3.87410712
13neutrophil activation involved in immune response (GO:0002283)3.82912801
14NIK/NF-kappaB signaling (GO:0038061)3.79550742
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79006413
16macrophage activation involved in immune response (GO:0002281)3.69035052
17positive regulation of gamma-delta T cell activation (GO:0046645)3.67216673
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.63369804
19response to host (GO:0075136)3.63369804
20response to host defenses (GO:0052200)3.63369804
21positive regulation of chemokine biosynthetic process (GO:0045080)3.58143225
22protein localization to endosome (GO:0036010)3.54460612
23regulation of interferon-beta biosynthetic process (GO:0045357)3.53435134
24regulation of interleukin-12 biosynthetic process (GO:0045075)3.48618145
25positive regulation of antigen processing and presentation (GO:0002579)3.47753658
26natural killer cell mediated immunity (GO:0002228)3.40789537
27natural killer cell mediated cytotoxicity (GO:0042267)3.40789537
28positive regulation of interferon-alpha production (GO:0032727)3.40716436
29regulation of antigen processing and presentation (GO:0002577)3.31574363
30positive regulation of heat generation (GO:0031652)3.30294536
31regulation of interferon-alpha production (GO:0032647)3.27848588
32hemidesmosome assembly (GO:0031581)3.26671365
33cell-substrate junction assembly (GO:0007044)3.23620001
34mannose metabolic process (GO:0006013)3.22143313
35immunoglobulin mediated immune response (GO:0016064)3.21045987
36COPI coating of Golgi vesicle (GO:0048205)3.19015509
37Golgi transport vesicle coating (GO:0048200)3.19015509
38skin morphogenesis (GO:0043589)3.15425667
39antigen processing and presentation of endogenous antigen (GO:0019883)3.15383653
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12310681
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12310681
42negative regulation of interleukin-12 production (GO:0032695)3.11497065
43I-kappaB phosphorylation (GO:0007252)3.11406039
44microglial cell activation (GO:0001774)3.07655469
45cell adhesion mediated by integrin (GO:0033627)3.05211228
46neutrophil activation (GO:0042119)3.00807784
47response to laminar fluid shear stress (GO:0034616)2.99808137
48stress fiber assembly (GO:0043149)2.99774632
49granulocyte activation (GO:0036230)2.98421476
50regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.96835356
51regulation of integrin activation (GO:0033623)2.94119660
52hypotonic response (GO:0006971)2.92905976
53myeloid cell activation involved in immune response (GO:0002275)2.89329654
54positive regulation of natural killer cell differentiation (GO:0032825)2.88348328
55lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87564393
56cell-substrate adherens junction assembly (GO:0007045)2.87028285
57focal adhesion assembly (GO:0048041)2.87028285
58positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87009172
59regulation of vitamin D biosynthetic process (GO:0060556)2.86600735
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86208262
61germinal center formation (GO:0002467)2.85611655
62adherens junction assembly (GO:0034333)2.84799497
63pinocytosis (GO:0006907)2.83858758
64positive regulation of endothelial cell apoptotic process (GO:2000353)2.82729042
65leukocyte aggregation (GO:0070486)2.82711866
66respiratory burst (GO:0045730)2.81779157
67regulation of chemokine biosynthetic process (GO:0045073)2.78231227
68regulation of early endosome to late endosome transport (GO:2000641)2.77644532
69positive regulation of extracellular matrix organization (GO:1903055)2.75669258
70T-helper 1 type immune response (GO:0042088)2.75571751
71positive regulation of cellular amide metabolic process (GO:0034250)2.74737520
72neutrophil mediated immunity (GO:0002446)2.72470851
73embryonic process involved in female pregnancy (GO:0060136)2.72348332
74regulation of fever generation (GO:0031620)2.72000312
75regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69959611
76regulation of B cell receptor signaling pathway (GO:0050855)2.69542360
77pentose-phosphate shunt (GO:0006098)2.68085376
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67965361
79epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66587579
80detection of other organism (GO:0098543)2.66531580
81cytokine secretion (GO:0050663)2.66054027
82wound healing, spreading of epidermal cells (GO:0035313)2.65059313
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64910667
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.63710604
85endodermal cell differentiation (GO:0035987)2.63130702
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62979633
87hyaluronan catabolic process (GO:0030214)2.62727606
88defense response to protozoan (GO:0042832)2.62065346
89negative regulation of mast cell activation (GO:0033004)2.61425254
90detection of molecule of bacterial origin (GO:0032490)2.61382036
91macrophage activation (GO:0042116)2.60813789
92response to interferon-alpha (GO:0035455)2.60267333
93modulation by symbiont of host cellular process (GO:0044068)2.58574641
94interferon-gamma-mediated signaling pathway (GO:0060333)2.57178577
95positive regulation of interleukin-12 production (GO:0032735)2.56666352
96barbed-end actin filament capping (GO:0051016)2.56652163
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56159508
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55543055
99regulation of vitamin metabolic process (GO:0030656)2.54734015
100response to type I interferon (GO:0034340)2.53640596
101superoxide anion generation (GO:0042554)2.53221625
102regulation of interleukin-12 production (GO:0032655)2.53028285
103response to protozoan (GO:0001562)2.53005006
104regulation of mast cell activation (GO:0033003)2.52040707
105cellular response to type I interferon (GO:0071357)2.51622548
106type I interferon signaling pathway (GO:0060337)2.51622548
107regulation of histone H3-K27 methylation (GO:0061085)2.50066753
108regulation of mast cell degranulation (GO:0043304)2.48438400
109positive regulation of interferon-beta production (GO:0032728)2.47962763
110dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45346622
111regulation of T-helper 1 cell differentiation (GO:0045625)2.45211859
112maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45149399
113positive regulation of chemokine production (GO:0032722)2.44917902
114negative regulation of fatty acid transport (GO:2000192)2.44705847
1153-UTR-mediated mRNA stabilization (GO:0070935)2.44247894
116nuclear pore complex assembly (GO:0051292)2.42953538
117B cell mediated immunity (GO:0019724)2.42626819
118leukocyte mediated cytotoxicity (GO:0001909)2.41604166
119leukocyte cell-cell adhesion (GO:0007159)2.41545624
120positive regulation of keratinocyte differentiation (GO:0045618)2.41330718
121positive regulation of leukocyte apoptotic process (GO:2000108)2.41187328
122cellular extravasation (GO:0045123)2.40529460
123regulation of NFAT protein import into nucleus (GO:0051532)2.40249266
124regulation of mast cell activation involved in immune response (GO:0033006)2.40150612
125B cell homeostasis (GO:0001782)2.39881882
126planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39864118
127regulation of podosome assembly (GO:0071801)2.39596629
128detection of biotic stimulus (GO:0009595)2.39479123
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39309036
130apoptotic cell clearance (GO:0043277)2.38850839
131apoptotic process involved in morphogenesis (GO:0060561)2.38428957
132positive regulation of tumor necrosis factor production (GO:0032760)2.38243033
133regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38133068
134regulation of necroptotic process (GO:0060544)2.37330082
135adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.37127943
136regulation of gamma-delta T cell activation (GO:0046643)2.36194680
137cellular response to virus (GO:0098586)2.36002357
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35971625
139positive regulation of mast cell activation (GO:0033005)2.35499052
140negative regulation of granulocyte differentiation (GO:0030853)2.35383488
141cellular response to interferon-alpha (GO:0035457)2.35175973
142cortical actin cytoskeleton organization (GO:0030866)2.34660884
143positive regulation of interleukin-6 production (GO:0032755)2.34541087
144histone H3-K36 demethylation (GO:0070544)2.32087176
145protein retention in ER lumen (GO:0006621)2.31670417
146positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31262709
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31256823
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.30921468
149membrane protein ectodomain proteolysis (GO:0006509)2.30476818
150epithelial cell-cell adhesion (GO:0090136)2.28327304
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27139938
152basement membrane organization (GO:0071711)2.26943677
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.24682071
154NADPH regeneration (GO:0006740)2.24123510
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23375796
156regulation of extracellular matrix disassembly (GO:0010715)2.21288669
157substrate-dependent cell migration (GO:0006929)2.19692482
158regulation of RNA export from nucleus (GO:0046831)2.18356331
159membrane raft organization (GO:0031579)2.18328003
160positive regulation of nuclease activity (GO:0032075)2.18316410
161low-density lipoprotein particle clearance (GO:0034383)2.17209036
162branching involved in mammary gland duct morphogenesis (GO:0060444)2.17152096
163myeloid dendritic cell differentiation (GO:0043011)2.17018602
164JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.16758903
165endoplasmic reticulum unfolded protein response (GO:0030968)2.16743582
166regulation of nucleobase-containing compound transport (GO:0032239)2.16108219
167negative regulation of viral release from host cell (GO:1902187)2.15001357
168adhesion of symbiont to host (GO:0044406)2.14411401
169activation of MAPKKK activity (GO:0000185)2.14365983
170semaphorin-plexin signaling pathway (GO:0071526)2.14036291
171regulation of extracellular matrix organization (GO:1903053)2.12866376
172glucose catabolic process (GO:0006007)2.12542227
173glycosphingolipid catabolic process (GO:0046479)2.11624919
174regulation of apoptotic process involved in morphogenesis (GO:1902337)2.11610549
175regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.11536339
176positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.11493436
177ER-nucleus signaling pathway (GO:0006984)2.11316992
178glucose 6-phosphate metabolic process (GO:0051156)2.11202615
179endocytic recycling (GO:0032456)2.08981415
180mesodermal cell differentiation (GO:0048333)2.08714828
181cellular response to thyroid hormone stimulus (GO:0097067)2.08444017
182decidualization (GO:0046697)2.08114059
183mRNA transcription (GO:0009299)2.08030741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.76942714
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.73732208
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.51049285
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.12993968
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.00680364
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.69511967
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50190387
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47954164
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.35043082
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34884694
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10412145
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01190221
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96283223
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92086587
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89963347
16E2F7_22180533_ChIP-Seq_HELA_Human2.79693877
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76756485
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69411299
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59670897
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22015842
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12949155
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08124052
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03957374
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97710709
25ZNF263_19887448_ChIP-Seq_K562_Human1.96313907
26LXR_22292898_ChIP-Seq_THP-1_Human1.93995705
27CLOCK_20551151_ChIP-Seq_293T_Human1.89739888
28SCL_19346495_ChIP-Seq_HPC-7_Human1.87894942
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85870497
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85620835
31SPI1_23547873_ChIP-Seq_NB4_Human1.84897282
32VDR_24763502_ChIP-Seq_THP-1_Human1.79228673
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76226363
34MYB_26560356_Chip-Seq_TH2_Human1.76059685
35VDR_21846776_ChIP-Seq_THP-1_Human1.75828785
36* SPI1_23127762_ChIP-Seq_K562_Human1.75678699
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74571847
38RACK7_27058665_Chip-Seq_MCF-7_Human1.71202862
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69534492
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69534492
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68356081
42PU_27001747_Chip-Seq_BMDM_Mouse1.67937837
43* MAF_26560356_Chip-Seq_TH1_Human1.67915835
44RUNX_20019798_ChIP-Seq_JUKART_Human1.65747838
45TCF7_22412390_ChIP-Seq_EML_Mouse1.64609450
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62108391
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.60887014
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.60276870
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57613378
50MYB_26560356_Chip-Seq_TH1_Human1.53153348
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52759065
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.49124367
53* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47788338
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47085203
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46721728
56VDR_24787735_ChIP-Seq_THP-1_Human1.46331330
57* GATA2_21666600_ChIP-Seq_HMVEC_Human1.43384948
58KDM2B_26808549_Chip-Seq_K562_Human1.38075330
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37004192
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.36941779
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.36586356
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34501643
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34304975
64* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34056126
65MYC_22102868_ChIP-Seq_BL_Human1.33501764
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.33417815
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33284791
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31349170
69* NCOR1_26117541_ChIP-Seq_K562_Human1.29595604
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.29550962
71UTX_26944678_Chip-Seq_JUKART_Human1.29407504
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27641618
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25745767
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23028525
75* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22029988
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21353544
77* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21288409
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20646828
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.20475119
80BRD4_25478319_ChIP-Seq_HGPS_Human1.20468207
81TP53_22127205_ChIP-Seq_IMR90_Human1.19789206
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18474333
83TFEB_21752829_ChIP-Seq_HELA_Human1.18193059
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17734114
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15885822
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15721638
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15647615
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.15265644
89* MAF_26560356_Chip-Seq_TH2_Human1.14919993
90* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14063633
91CJUN_26792858_Chip-Seq_BT549_Human1.13599951
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11427415
93* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11262927
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10455318
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10213079
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09911140
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09595510
98GATA1_19941826_ChIP-Seq_K562_Human1.07894274
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.07274785
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06669893
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06307714
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05185273
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05120575
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04999752
105* GATA3_27048872_Chip-Seq_THYMUS_Human1.04397426
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03972480
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03708231
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03692368
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03133231
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02759078
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02500457
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02002024
113* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00236635
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00166812
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99613774
116KDM2B_26808549_Chip-Seq_DND41_Human0.98559994
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98413551
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98029493
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97998299
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97689471
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97656567
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96233934
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.94994849
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93746869
125GATA3_26560356_Chip-Seq_TH2_Human0.93171777
126* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92119695
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90468481
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89689505
129* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89208284
130ATF3_27146783_Chip-Seq_COLON_Human0.87721151
131GATA1_22025678_ChIP-Seq_K562_Human0.87586037
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.85859967
133* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81821640
134* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81392278
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81315821
136* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81272900
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81070903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.28294295
2MP0000569_abnormal_digit_pigmentation3.21654975
3MP0003436_decreased_susceptibility_to2.86368797
4MP0003303_peritoneal_inflammation2.84344462
5MP0005451_abnormal_body_composition2.55233784
6MP0009785_altered_susceptibility_to2.42332576
7MP0008438_abnormal_cutaneous_collagen2.40353716
8MP0009278_abnormal_bone_marrow2.39110011
9MP0002419_abnormal_innate_immunity2.35267636
10MP0000685_abnormal_immune_system2.33893752
11MP0004510_myositis2.33409534
12MP0010352_gastrointestinal_tract_polyps2.22033785
13MP0005000_abnormal_immune_tolerance2.21978619
14MP0002148_abnormal_hypersensitivity_rea2.21868968
15MP0003566_abnormal_cell_adhesion2.17263340
16MP0005387_immune_system_phenotype2.15962582
17MP0001790_abnormal_immune_system2.15962582
18MP0005058_abnormal_lysosome_morphology2.13546241
19MP0003300_gastrointestinal_ulcer2.08565242
20MP0004947_skin_inflammation2.03680205
21MP0002452_abnormal_antigen_presenting2.02865172
22MP0002877_abnormal_melanocyte_morpholog2.02685871
23MP0005025_abnormal_response_to2.01896149
24MP0009840_abnormal_foam_cell1.90900482
25MP0001849_ear_inflammation1.90528980
26MP0005076_abnormal_cell_differentiation1.90110951
27MP0001800_abnormal_humoral_immune1.88429236
28MP0003705_abnormal_hypodermis_morpholog1.87478911
29MP0006082_CNS_inflammation1.84571196
30MP0002723_abnormal_immune_serum1.79263310
31MP0005671_abnormal_response_to1.71361785
32* MP0001819_abnormal_immune_cell1.68983638
33MP0002254_reproductive_system_inflammat1.67982922
34MP0002405_respiratory_system_inflammati1.67800203
35* MP0002420_abnormal_adaptive_immunity1.67559142
36MP0004272_abnormal_basement_membrane1.67515952
37MP0005275_abnormal_skin_tensile1.67099684
38MP0002006_tumorigenesis1.64797895
39MP0003448_altered_tumor_morphology1.64636359
40MP0005464_abnormal_platelet_physiology1.64601955
41MP0003172_abnormal_lysosome_physiology1.60665910
42MP0001533_abnormal_skeleton_physiology1.59666504
43MP0010307_abnormal_tumor_latency1.57943864
44MP0005397_hematopoietic_system_phenotyp1.56931728
45MP0001545_abnormal_hematopoietic_system1.56931728
46MP0001958_emphysema1.55664447
47MP0002166_altered_tumor_susceptibility1.54961881
48MP0003091_abnormal_cell_migration1.53852204
49MP0003191_abnormal_cellular_cholesterol1.51891149
50MP0004808_abnormal_hematopoietic_stem1.51680792
51MP0004185_abnormal_adipocyte_glucose1.46099892
52MP0006054_spinal_hemorrhage1.45293098
53MP0004233_abnormal_muscle_weight1.45277497
54MP0008260_abnormal_autophagy1.43537733
55MP0000858_altered_metastatic_potential1.40810812
56MP0004858_abnormal_nervous_system1.40642258
57MP0001853_heart_inflammation1.40376206
58MP0003724_increased_susceptibility_to1.38994131
59MP0003045_fibrosis1.35710009
60MP0010155_abnormal_intestine_physiology1.33512390
61MP0005023_abnormal_wound_healing1.32261725
62MP0000343_altered_response_to1.31680191
63MP0003453_abnormal_keratinocyte_physiol1.30699012
64MP0000383_abnormal_hair_follicle1.29132001
65MP0002998_abnormal_bone_remodeling1.27983463
66MP0002398_abnormal_bone_marrow1.27097031
67* MP0001845_abnormal_inflammatory_respons1.24224972
68MP0001873_stomach_inflammation1.21946195
69MP0005174_abnormal_tail_pigmentation1.21773582
70MP0002060_abnormal_skin_morphology1.21379296
71MP0003828_pulmonary_edema1.21226445
72MP0005257_abnormal_intraocular_pressure1.21028263
73MP0000716_abnormal_immune_system1.20446390
74MP0000371_diluted_coat_color1.20113469
75MP0005310_abnormal_salivary_gland1.19414709
76MP0000733_abnormal_muscle_development1.19092980
77MP0002396_abnormal_hematopoietic_system1.18179579
78MP0001915_intracranial_hemorrhage1.17454279
79MP0005409_darkened_coat_color1.15429455
80MP0003183_abnormal_peptide_metabolism1.10537105
81MP0009333_abnormal_splenocyte_physiolog1.09881888
82MP0002796_impaired_skin_barrier1.06383428
83MP0003279_aneurysm1.05116257
84MP0005390_skeleton_phenotype1.02811704
85MP0005623_abnormal_meninges_morphology1.00402226
86MP0000689_abnormal_spleen_morphology1.00280209
87MP0002722_abnormal_immune_system0.99791311
88MP0002429_abnormal_blood_cell0.98221044
89MP0002933_joint_inflammation0.96751352
90MP0000465_gastrointestinal_hemorrhage0.95468258
91MP0010678_abnormal_skin_adnexa0.94905237
92MP0003763_abnormal_thymus_physiology0.94727856
93MP0000767_abnormal_smooth_muscle0.91871220
94MP0001216_abnormal_epidermal_layer0.89193105
95MP0001851_eye_inflammation0.87829223
96MP0000015_abnormal_ear_pigmentation0.87430659
97MP0005164_abnormal_response_to0.85127807
98MP0002089_abnormal_postnatal_growth/wei0.84697395
99MP0003656_abnormal_erythrocyte_physiolo0.84560670
100MP0002896_abnormal_bone_mineralization0.84162149
101MP0001243_abnormal_dermal_layer0.81890782
102MP0001348_abnormal_lacrimal_gland0.81411536
103MP0005666_abnormal_adipose_tissue0.81342038
104MP0003795_abnormal_bone_structure0.81341883
105MP0008469_abnormal_protein_level0.80718234
106MP0001730_embryonic_growth_arrest0.79095140
107MP0005501_abnormal_skin_physiology0.78621744
108MP0003950_abnormal_plasma_membrane0.78486823
109MP0000604_amyloidosis0.78057287
110MP0009931_abnormal_skin_appearance0.77527112
111MP0000490_abnormal_crypts_of0.77080180
112MP0001191_abnormal_skin_condition0.76748573
113MP0009764_decreased_sensitivity_to0.76135956
114MP0002277_abnormal_respiratory_mucosa0.76005314
115MP0002332_abnormal_exercise_endurance0.74146436
116MP0005621_abnormal_cell_physiology0.73149920
117MP0000703_abnormal_thymus_morphology0.71953729
118MP0003075_altered_response_to0.71708247
119MP0008057_abnormal_DNA_replication0.64697944
120MP0002928_abnormal_bile_duct0.64673175
121MP0003941_abnormal_skin_development0.64632418
122MP0000627_abnormal_mammary_gland0.63839642
123MP0008007_abnormal_cellular_replicative0.61267235
124MP0010234_abnormal_vibrissa_follicle0.60529332

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.11382057
2Eczematoid dermatitis (HP:0000976)4.90873467
3Recurrent bacterial skin infections (HP:0005406)4.50655095
4Myositis (HP:0100614)3.56173424
5Mediastinal lymphadenopathy (HP:0100721)3.51304531
6Osteolytic defects of the hand bones (HP:0009699)3.37821667
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.37821667
8Increased cerebral lipofuscin (HP:0011813)3.36305123
9Orchitis (HP:0100796)3.28470988
10Thick nail (HP:0001805)3.22918510
11Elevated erythrocyte sedimentation rate (HP:0003565)3.22669678
12Retrobulbar optic neuritis (HP:0100654)3.14826749
13Optic neuritis (HP:0100653)3.14826749
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.10615864
15Prostate neoplasm (HP:0100787)3.09931186
16Abnormality of macrophages (HP:0004311)3.02369477
17Recurrent fungal infections (HP:0002841)3.01291561
18Gingivitis (HP:0000230)2.96552919
19Absent frontal sinuses (HP:0002688)2.89013160
20Spondylolisthesis (HP:0003302)2.86125442
21Recurrent gram-negative bacterial infections (HP:0005420)2.85336008
22Periodontitis (HP:0000704)2.82122971
23Broad face (HP:0000283)2.80808628
24Premature rupture of membranes (HP:0001788)2.73847350
25Hyperacusis (HP:0010780)2.70101672
26Recurrent skin infections (HP:0001581)2.69704944
27Vertebral compression fractures (HP:0002953)2.67618653
28Spinal cord lesions (HP:0100561)2.64771561
29Syringomyelia (HP:0003396)2.64771561
30Hematochezia (HP:0002573)2.63958432
31Stomatitis (HP:0010280)2.59652122
32Vacuolated lymphocytes (HP:0001922)2.53901134
33Dysostosis multiplex (HP:0000943)2.50838579
34Arterial tortuosity (HP:0005116)2.49197287
35Distal lower limb amyotrophy (HP:0008944)2.48377705
36Vascular tortuosity (HP:0004948)2.48265463
37Increased IgE level (HP:0003212)2.47980227
38Peritonitis (HP:0002586)2.42377132
39Increased density of long bones (HP:0006392)2.42224059
40Obstructive lung disease (HP:0006536)2.41106005
41Chronic obstructive pulmonary disease (HP:0006510)2.41106005
42Arterial thrombosis (HP:0004420)2.38575184
43Cellulitis (HP:0100658)2.36508789
44Flat acetabular roof (HP:0003180)2.34543806
45Recurrent viral infections (HP:0004429)2.32524427
46Chronic mucocutaneous candidiasis (HP:0002728)2.30546462
47Recurrent cutaneous fungal infections (HP:0011370)2.30546462
48Disproportionate tall stature (HP:0001519)2.28945169
49Increased connective tissue (HP:0009025)2.27710391
50Pustule (HP:0200039)2.24630496
51Wormian bones (HP:0002645)2.24625580
52Vasculitis (HP:0002633)2.24421072
53Premature loss of primary teeth (HP:0006323)2.23958024
54Pulmonary infiltrates (HP:0002113)2.22580341
55Cerebral aneurysm (HP:0004944)2.21318118
56Abnormality of oral frenula (HP:0000190)2.20946367
57Atrophic scars (HP:0001075)2.20923365
58Cervical subluxation (HP:0003308)2.20140868
59Blue sclerae (HP:0000592)2.19115379
60Autoimmune thrombocytopenia (HP:0001973)2.18350988
61Mucopolysacchariduria (HP:0008155)2.17965930
62Urinary glycosaminoglycan excretion (HP:0003541)2.17965930
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17601486
64Short nail (HP:0001799)2.17363617
65Aneurysm (HP:0002617)2.16577294
66Thin bony cortex (HP:0002753)2.14974665
67Interstitial pulmonary disease (HP:0006530)2.14865063
68Ankyloglossia (HP:0010296)2.14359112
69Spinal rigidity (HP:0003306)2.12974703
70Bladder diverticulum (HP:0000015)2.09649162
71Mitral valve prolapse (HP:0001634)2.09497285
72Frequent falls (HP:0002359)2.09334973
73Abnormality of the frontal sinuses (HP:0002687)2.08722579
74Achilles tendon contracture (HP:0001771)2.08117474
75Abnormality of the thoracic spine (HP:0100711)2.07435216
76Shallow orbits (HP:0000586)2.07137613
77Osteomyelitis (HP:0002754)2.06268122
78Abnormality of polysaccharide metabolism (HP:0011012)2.04269806
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04269806
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04269806
81Ankle contracture (HP:0006466)2.01696538
82Natal tooth (HP:0000695)2.00710036
83Protrusio acetabuli (HP:0003179)1.99716620
84Genu recurvatum (HP:0002816)1.97632594
85Persistence of primary teeth (HP:0006335)1.97210723
86Mitral regurgitation (HP:0001653)1.97199857
87Myocardial infarction (HP:0001658)1.97053629
88Chronic otitis media (HP:0000389)1.95425560
89Abnormality of liposaccharide metabolism (HP:0010968)1.95308223
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.95308223
91Abnormality of glycolipid metabolism (HP:0010969)1.95308223
92Dilatation of the ascending aorta (HP:0005111)1.92597876
93Thoracic kyphosis (HP:0002942)1.92465427
94Keratoconjunctivitis (HP:0001096)1.91367967
95Disinhibition (HP:0000734)1.91242306
96Biconcave vertebral bodies (HP:0004586)1.91078612
97Emphysema (HP:0002097)1.89488623
98Joint laxity (HP:0001388)1.88372022
99Long palpebral fissure (HP:0000637)1.88273024
100Thrombocytosis (HP:0001894)1.87346831
101Abnormality of the Achilles tendon (HP:0005109)1.85821229
102Abnormality of the acetabulum (HP:0003170)1.85229840
103Distal lower limb muscle weakness (HP:0009053)1.83661306
104Urticaria (HP:0001025)1.83530843
105Keratoconjunctivitis sicca (HP:0001097)1.82253369
106Selective tooth agenesis (HP:0001592)1.82094991
107Loss of speech (HP:0002371)1.81921999
108Leukocytosis (HP:0001974)1.81589330
109Nasal polyposis (HP:0100582)1.81505773
110Elbow flexion contracture (HP:0002987)1.80647011
111Tetraparesis (HP:0002273)1.80149402
112Premature skin wrinkling (HP:0100678)1.77959287
113Upper limb amyotrophy (HP:0009129)1.77501719
114Distal upper limb amyotrophy (HP:0007149)1.77501719
115Basal ganglia calcification (HP:0002135)1.77460805
116Lip pit (HP:0100267)1.76365230
117Increased variability in muscle fiber diameter (HP:0003557)1.76318170
118Abnormal ossification of hand bones (HP:0005921)1.76003156
119Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75932661
120Colitis (HP:0002583)1.75498951
121Hypergammaglobulinemia (HP:0010702)1.75031322
122Dislocated radial head (HP:0003083)1.74451171
123Abnormality of the distal phalanges of the toes (HP:0010182)1.74292925
124Pulmonary artery stenosis (HP:0004415)1.73554263
125Milia (HP:0001056)1.72776345
126Lower limb amyotrophy (HP:0007210)1.72544970
127Inflammation of the large intestine (HP:0002037)1.71495902
128Urethral obstruction (HP:0000796)1.70196857
129Bone pain (HP:0002653)1.70177087
130Aortic dissection (HP:0002647)1.70155322
131Advanced eruption of teeth (HP:0006288)1.69680048
132Abnormality of the nasal septum (HP:0000419)1.68762417
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.68062323
134Abnormality of the fingertips (HP:0001211)1.67885793
135Bruising susceptibility (HP:0000978)1.67707197
136Ulnar bowing (HP:0003031)1.67588399
137Abnormality of skeletal muscle fiber size (HP:0012084)1.67381367
138Skin ulcer (HP:0200042)1.67232571
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66955873
140Axonal loss (HP:0003447)1.66253361
141Nuclear cataract (HP:0100018)1.65968457
142Aortic aneurysm (HP:0004942)1.65419336
143Fragile skin (HP:0001030)1.65197829
144Hand muscle atrophy (HP:0009130)1.64870302
145Abnormality of dentin (HP:0010299)1.64767391
146Subacute progressive viral hepatitis (HP:0006572)1.64502858
147Long eyelashes (HP:0000527)1.64423285
148Aortic regurgitation (HP:0001659)1.63897046
149Asymmetry of the thorax (HP:0001555)1.63851779
150Radial bowing (HP:0002986)1.62531267
151Cupped ribs (HP:0000887)1.61814921
152Obstructive sleep apnea (HP:0002870)1.59886054
153Abnormality of carpal bone ossification (HP:0006257)1.59592865
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.59359263
155Polygenic inheritance (HP:0010982)1.58063299
156Coarse hair (HP:0002208)1.54619486
157Asymmetric septal hypertrophy (HP:0001670)1.54368617
158Abnormality of the lumbar spine (HP:0100712)1.54050685
159Joint stiffness (HP:0001387)1.53875729
160Vertebral arch anomaly (HP:0008438)1.52848481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.24901511
2TTN3.28763137
3PRPF4B3.07627560
4SMG12.79634432
5TBK12.79210068
6IRAK42.72859866
7BLK2.68061918
8TYK22.61541265
9ICK2.48292821
10JAK32.44943083
11KIT2.43492043
12RIPK42.42115235
13IRAK32.40097332
14SIK12.36733850
15CDK122.30506192
16IKBKB2.21760104
17IKBKE2.20509502
18JAK11.93906824
19MAP4K11.91882253
20CHUK1.87262864
21NME21.79661782
22RPS6KA41.72134397
23TRPM71.63991343
24RIPK11.63402887
25TRIB31.60627407
26CDC42BPA1.55367627
27TXK1.52054826
28CAMK1D1.46511138
29NEK91.45927897
30ZAP701.44859990
31PIM21.43959254
32CSK1.42820006
33MAP3K131.39750847
34TAOK21.39725164
35EPHB11.35291773
36EEF2K1.34413319
37PTK61.31646178
38PKN21.31348293
39MATK1.30827863
40HCK1.26245880
41MAP2K31.23992803
42STK101.17192579
43CSF1R1.17053609
44PIM11.13209452
45BMX1.11197322
46LATS21.09985548
47FGFR31.07819053
48BTK1.07370608
49ERN11.06950390
50MAP3K31.02824773
51LRRK21.00134089
52CDK60.99392816
53LCK0.97328754
54STK30.94260423
55EPHA20.92290290
56TEC0.89966898
57EPHA30.88161912
58STK40.87707243
59TGFBR20.87241352
60PDGFRA0.85863473
61PRKD20.84461606
62FGR0.83098379
63SYK0.82300449
64DDR20.81835301
65MELK0.81729508
66PDGFRB0.81163786
67MAPK110.80358405
68BRD40.78876949
69CAMK1G0.78865210
70MAP3K10.77706905
71PAK40.77412142
72MARK20.76515138
73FLT30.76418687
74LYN0.75356081
75JAK20.72743443
76HIPK20.71567841
77MOS0.68351561
78TYRO30.67748090
79TAOK30.67308498
80MAP3K80.66042984
81TAOK10.65194439
82LATS10.64665896
83MARK30.64148863
84KSR20.63641416
85MAP3K70.63250061
86EGFR0.62225554
87ITK0.60594611
88YES10.59402746
89ABL10.59255463
90EIF2AK20.58855976
91NTRK10.58806290
92MAP3K100.58609266
93PIK3CG0.58480046
94MST1R0.58240379
95GRK70.57980908
96MAP3K60.57084951
97SCYL20.56066545
98MET0.55667536
99NEK20.55467492
100MTOR0.55165600
101CDK40.54454945
102FGFR40.54396614
103ZAK0.54352760
104PDPK10.53646969
105MAPKAPK20.53391305
106DMPK0.53384482
107IRAK20.52814676
108CDK90.52475098
109ARAF0.52264592
110NUAK10.51988401
111CDK70.50859655
112SIK20.50231348
113MAP3K50.49740224
114PAK20.48015917
115RPS6KA60.46696846
116CLK10.46420040
117SIK30.46050461
118MAP3K110.45134018
119PBK0.43935303
120RPS6KB20.43190669
121CDK80.42741524
122MAPKAPK30.40722669
123ALK0.40654375
124PTK20.40515877
125MAPK70.39916664
126FES0.39618034
127ATR0.39326619
128IRAK10.38706098
129INSR0.38109134
130RPS6KL10.36727029
131RPS6KC10.36727029
132TGFBR10.35437082
133ERBB30.35431735
134RPS6KA20.34783052

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.92648574
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.45459012
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22805996
4Osteoclast differentiation_Homo sapiens_hsa043802.18462016
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15263676
6Legionellosis_Homo sapiens_hsa051342.04331916
7Malaria_Homo sapiens_hsa051442.03387696
8TNF signaling pathway_Homo sapiens_hsa046681.94760333
9Graft-versus-host disease_Homo sapiens_hsa053321.92831312
10Measles_Homo sapiens_hsa051621.89926992
11Allograft rejection_Homo sapiens_hsa053301.84227349
12Toxoplasmosis_Homo sapiens_hsa051451.83091221
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80292272
14Pertussis_Homo sapiens_hsa051331.75651592
15Bladder cancer_Homo sapiens_hsa052191.75282017
16Tuberculosis_Homo sapiens_hsa051521.72120905
17Asthma_Homo sapiens_hsa053101.70397619
18Influenza A_Homo sapiens_hsa051641.61715766
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55775199
20Hematopoietic cell lineage_Homo sapiens_hsa046401.51932442
21B cell receptor signaling pathway_Homo sapiens_hsa046621.50852093
22Apoptosis_Homo sapiens_hsa042101.49041592
23Salmonella infection_Homo sapiens_hsa051321.48143268
24Shigellosis_Homo sapiens_hsa051311.47577986
25Herpes simplex infection_Homo sapiens_hsa051681.47484631
26Small cell lung cancer_Homo sapiens_hsa052221.46502160
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44751064
28Antigen processing and presentation_Homo sapiens_hsa046121.36492182
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35359670
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.35026482
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.33830447
32Rheumatoid arthritis_Homo sapiens_hsa053231.33586336
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32558057
34Chronic myeloid leukemia_Homo sapiens_hsa052201.31679247
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30871240
36Amoebiasis_Homo sapiens_hsa051461.30385988
37Viral myocarditis_Homo sapiens_hsa054161.28252892
38Staphylococcus aureus infection_Homo sapiens_hsa051501.25986419
39Lysosome_Homo sapiens_hsa041421.23245894
40Phagosome_Homo sapiens_hsa041451.22214641
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21032487
42Thyroid cancer_Homo sapiens_hsa052161.19373346
43Hepatitis B_Homo sapiens_hsa051611.18565552
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.18330015
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17177482
46Chemokine signaling pathway_Homo sapiens_hsa040621.15953340
47Renal cell carcinoma_Homo sapiens_hsa052111.15151696
48Prion diseases_Homo sapiens_hsa050201.08080050
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.06578978
50ECM-receptor interaction_Homo sapiens_hsa045121.06520593
51Pentose phosphate pathway_Homo sapiens_hsa000301.06355525
52Acute myeloid leukemia_Homo sapiens_hsa052211.05948661
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05933030
54Endometrial cancer_Homo sapiens_hsa052131.04957624
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00366756
56Type I diabetes mellitus_Homo sapiens_hsa049401.00330336
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00265918
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98635254
59Focal adhesion_Homo sapiens_hsa045100.97855050
60Proteoglycans in cancer_Homo sapiens_hsa052050.97192676
61Pancreatic cancer_Homo sapiens_hsa052120.96666715
62Hepatitis C_Homo sapiens_hsa051600.96334502
63* MicroRNAs in cancer_Homo sapiens_hsa052060.95035086
64Platelet activation_Homo sapiens_hsa046110.94637148
65African trypanosomiasis_Homo sapiens_hsa051430.93249136
66T cell receptor signaling pathway_Homo sapiens_hsa046600.92021427
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89315528
68Viral carcinogenesis_Homo sapiens_hsa052030.88364576
69Primary immunodeficiency_Homo sapiens_hsa053400.88199461
70Galactose metabolism_Homo sapiens_hsa000520.87290568
71Glioma_Homo sapiens_hsa052140.86906132
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.86643915
73Fructose and mannose metabolism_Homo sapiens_hsa000510.86360582
74HTLV-I infection_Homo sapiens_hsa051660.82771475
75p53 signaling pathway_Homo sapiens_hsa041150.82321795
76Other glycan degradation_Homo sapiens_hsa005110.81767846
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81385628
78ErbB signaling pathway_Homo sapiens_hsa040120.81374729
79Autoimmune thyroid disease_Homo sapiens_hsa053200.79946226
80Colorectal cancer_Homo sapiens_hsa052100.79530311
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78956116
82Adherens junction_Homo sapiens_hsa045200.78784047
83Epstein-Barr virus infection_Homo sapiens_hsa051690.77754795
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77045550
85Notch signaling pathway_Homo sapiens_hsa043300.76181292
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.73754675
87HIF-1 signaling pathway_Homo sapiens_hsa040660.73731652
88Insulin signaling pathway_Homo sapiens_hsa049100.69921584
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69526112
90Prolactin signaling pathway_Homo sapiens_hsa049170.69518670
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.68742699
92Choline metabolism in cancer_Homo sapiens_hsa052310.65345777
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65141148
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60924733
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60430543
96GnRH signaling pathway_Homo sapiens_hsa049120.60033007
97N-Glycan biosynthesis_Homo sapiens_hsa005100.58332074
98Lysine degradation_Homo sapiens_hsa003100.56656227
99VEGF signaling pathway_Homo sapiens_hsa043700.56347191
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55884140
101Prostate cancer_Homo sapiens_hsa052150.55205591
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54711786
103mTOR signaling pathway_Homo sapiens_hsa041500.54331431
104Type II diabetes mellitus_Homo sapiens_hsa049300.53115729
105Dilated cardiomyopathy_Homo sapiens_hsa054140.52845025
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52617691
107Inositol phosphate metabolism_Homo sapiens_hsa005620.51218316
108Insulin resistance_Homo sapiens_hsa049310.50757267
109Pathways in cancer_Homo sapiens_hsa052000.50714264
110Dorso-ventral axis formation_Homo sapiens_hsa043200.49084955
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48804193
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47794332
113FoxO signaling pathway_Homo sapiens_hsa040680.46699786
114Sphingolipid metabolism_Homo sapiens_hsa006000.45903359
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45878525
116Melanoma_Homo sapiens_hsa052180.45132862
117* Sphingolipid signaling pathway_Homo sapiens_hsa040710.45059286
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44343060
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.44139680
120MAPK signaling pathway_Homo sapiens_hsa040100.43531702
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43486551
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40677838
123Non-small cell lung cancer_Homo sapiens_hsa052230.40467470
124Endocytosis_Homo sapiens_hsa041440.39527179

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