ABCB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.39388711
2epoxygenase P450 pathway (GO:0019373)7.78843197
3omega-hydroxylase P450 pathway (GO:0097267)7.47878707
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.39779331
5L-phenylalanine catabolic process (GO:0006559)7.39779331
6L-phenylalanine metabolic process (GO:0006558)7.06909497
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.06909497
8aromatic amino acid family catabolic process (GO:0009074)6.76922292
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26487573
10tryptophan catabolic process (GO:0006569)6.23111062
11indole-containing compound catabolic process (GO:0042436)6.23111062
12indolalkylamine catabolic process (GO:0046218)6.23111062
13kynurenine metabolic process (GO:0070189)6.09199329
14oxidative demethylation (GO:0070989)6.03680370
15bile acid biosynthetic process (GO:0006699)5.95988170
16tryptophan metabolic process (GO:0006568)5.87473015
17drug metabolic process (GO:0017144)5.63623944
18urea metabolic process (GO:0019627)5.60995621
19urea cycle (GO:0000050)5.60995621
20glyoxylate metabolic process (GO:0046487)5.59362249
21alpha-linolenic acid metabolic process (GO:0036109)5.58724083
22high-density lipoprotein particle remodeling (GO:0034375)5.46763548
23protein carboxylation (GO:0018214)5.43417744
24peptidyl-glutamic acid carboxylation (GO:0017187)5.43417744
25negative regulation of fibrinolysis (GO:0051918)5.41220968
26regulation of protein activation cascade (GO:2000257)5.31757073
27cysteine metabolic process (GO:0006534)5.31625382
28complement activation, alternative pathway (GO:0006957)5.31324118
29regulation of fibrinolysis (GO:0051917)5.28326387
30regulation of plasminogen activation (GO:0010755)5.27965645
31nitrogen cycle metabolic process (GO:0071941)5.16618669
32serine family amino acid catabolic process (GO:0009071)5.15876193
33sulfur amino acid catabolic process (GO:0000098)5.13532138
34bile acid metabolic process (GO:0008206)5.07417809
35regulation of humoral immune response (GO:0002920)5.05663861
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04945816
37phenylpropanoid metabolic process (GO:0009698)5.00941176
38regulation of complement activation (GO:0030449)4.96038628
39aromatic amino acid family metabolic process (GO:0009072)4.90812385
40negative regulation of hemostasis (GO:1900047)4.90787415
41negative regulation of blood coagulation (GO:0030195)4.90787415
42homocysteine metabolic process (GO:0050667)4.87521270
43regulation of triglyceride catabolic process (GO:0010896)4.85794769
44reverse cholesterol transport (GO:0043691)4.79009030
45negative regulation of protein activation cascade (GO:2000258)4.76181118
46lysine catabolic process (GO:0006554)4.73936522
47lysine metabolic process (GO:0006553)4.73936522
48regulation of cholesterol esterification (GO:0010872)4.72990249
49protein-lipid complex remodeling (GO:0034368)4.72600928
50macromolecular complex remodeling (GO:0034367)4.72600928
51plasma lipoprotein particle remodeling (GO:0034369)4.72600928
52amino-acid betaine metabolic process (GO:0006577)4.71203272
53tyrosine metabolic process (GO:0006570)4.69568017
54alpha-amino acid catabolic process (GO:1901606)4.62846431
55acute-phase response (GO:0006953)4.59254254
56triglyceride homeostasis (GO:0070328)4.56458171
57acylglycerol homeostasis (GO:0055090)4.56458171
58phospholipid efflux (GO:0033700)4.54057310
59bile acid and bile salt transport (GO:0015721)4.48539321
60imidazole-containing compound metabolic process (GO:0052803)4.43932698
61negative regulation of coagulation (GO:0050819)4.43720984
62indolalkylamine metabolic process (GO:0006586)4.43234862
63glycine metabolic process (GO:0006544)4.43091021
64cellular ketone body metabolic process (GO:0046950)4.41177170
65negative regulation of sterol transport (GO:0032372)4.41164116
66negative regulation of cholesterol transport (GO:0032375)4.41164116
67negative regulation of wound healing (GO:0061045)4.38643659
68cellular biogenic amine catabolic process (GO:0042402)4.37615078
69amine catabolic process (GO:0009310)4.37615078
70coenzyme catabolic process (GO:0009109)4.34290370
71positive regulation of blood coagulation (GO:0030194)4.31266205
72positive regulation of hemostasis (GO:1900048)4.31266205
73plasma lipoprotein particle clearance (GO:0034381)4.30994123
74cellular amino acid catabolic process (GO:0009063)4.22148350
75cellular glucuronidation (GO:0052695)4.22049406
76cholesterol efflux (GO:0033344)4.21495846
77hormone catabolic process (GO:0042447)4.15289898
78alkaloid metabolic process (GO:0009820)4.13719711
79serine family amino acid metabolic process (GO:0009069)4.13224882
80glutamate metabolic process (GO:0006536)4.11832778
81blood coagulation, intrinsic pathway (GO:0007597)4.10119326
82ethanol oxidation (GO:0006069)4.06766386
83ethanol metabolic process (GO:0006067)4.06700954
84plasma lipoprotein particle assembly (GO:0034377)4.06649100
85benzene-containing compound metabolic process (GO:0042537)4.05291796
86low-density lipoprotein particle remodeling (GO:0034374)4.01727547
87positive regulation of coagulation (GO:0050820)4.00739719
88negative regulation of complement activation (GO:0045916)3.99919872
89dicarboxylic acid biosynthetic process (GO:0043650)3.95571178
90cellular modified amino acid catabolic process (GO:0042219)3.92616455
91arginine metabolic process (GO:0006525)3.92590010
92very-low-density lipoprotein particle assembly (GO:0034379)3.92406193
93fibrinolysis (GO:0042730)3.91511166
94aldehyde catabolic process (GO:0046185)3.88347386
95cofactor catabolic process (GO:0051187)3.84336533
96S-adenosylmethionine metabolic process (GO:0046500)3.83647058
97ketone body metabolic process (GO:1902224)3.80157930
98positive regulation of lipoprotein lipase activity (GO:0051006)3.79243265
99positive regulation of triglyceride lipase activity (GO:0061365)3.79243265
100protein activation cascade (GO:0072376)3.79209669
101positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.78911487
102phospholipid homeostasis (GO:0055091)3.78812313
103negative regulation of lipase activity (GO:0060192)3.78350647
104opsonization (GO:0008228)3.77696376
105serine family amino acid biosynthetic process (GO:0009070)3.77634783
106complement activation, classical pathway (GO:0006958)3.76403810
107heme transport (GO:0015886)3.76102484
108intestinal cholesterol absorption (GO:0030299)3.75370405
109drug catabolic process (GO:0042737)3.75313141
110carboxylic acid catabolic process (GO:0046395)3.74786039
111organic acid catabolic process (GO:0016054)3.74786039
112NAD biosynthetic process (GO:0009435)3.72608996
113complement activation (GO:0006956)3.72540340
114disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.72288501
115killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.72288501
116uronic acid metabolic process (GO:0006063)3.71618070
117glucuronate metabolic process (GO:0019585)3.71618070
118short-chain fatty acid metabolic process (GO:0046459)3.70748626
119cholesterol homeostasis (GO:0042632)3.70474010
120positive regulation of lipid catabolic process (GO:0050996)3.68707419
121regulation of lipoprotein particle clearance (GO:0010984)3.67165438
122nicotinamide nucleotide biosynthetic process (GO:0019359)3.66061305
123pyridine nucleotide biosynthetic process (GO:0019363)3.66061305
124cytolysis (GO:0019835)3.65830694
125plasma lipoprotein particle organization (GO:0071827)3.65395176
126sterol homeostasis (GO:0055092)3.63695918
127flavonoid metabolic process (GO:0009812)3.63141731
128acetyl-CoA metabolic process (GO:0006084)3.62946741
129protein-lipid complex assembly (GO:0065005)3.62943663
130regulation of bile acid biosynthetic process (GO:0070857)3.62593846
131regulation of apoptotic cell clearance (GO:2000425)3.57461539
132fat-soluble vitamin biosynthetic process (GO:0042362)3.52784644
133acute inflammatory response (GO:0002526)3.51593278
134response to mercury ion (GO:0046689)3.46854987
135steroid catabolic process (GO:0006706)3.44866412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30928527
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.30367518
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11283088
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.41379650
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.25377370
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13144601
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.60198455
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.13634303
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01337249
10EZH2_22144423_ChIP-Seq_EOC_Human2.44009878
11GATA1_22025678_ChIP-Seq_K562_Human2.21348407
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12152730
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8721753
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96404993
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92897407
16HTT_18923047_ChIP-ChIP_STHdh_Human1.69019804
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.56470641
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.51457218
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.40767714
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32621507
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23328407
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21594225
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20426295
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.19188832
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17327336
26CLOCK_20551151_ChIP-Seq_293T_Human1.15604135
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14737407
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06543641
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02711421
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91395631
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90676552
32GATA1_19941827_ChIP-Seq_MEL_Mouse0.87531624
33ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87020650
34SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81429676
35KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81425267
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78840740
37AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78274093
38* ER_23166858_ChIP-Seq_MCF-7_Human0.77867912
39GATA4_25053715_ChIP-Seq_YYC3_Human0.77518264
40SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77131136
41TCF4_18268006_ChIP-ChIP_LS174T_Human0.76288046
42HNFA_21074721_ChIP-Seq_CACO-2_Human0.75575690
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75479579
44SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75366630
45CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74428591
46SOX2_21211035_ChIP-Seq_LN229_Human0.73914880
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73426849
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72415113
49PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72225774
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71812346
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71171923
52CBP_20019798_ChIP-Seq_JUKART_Human0.71171923
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70739226
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70675777
55* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69616656
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69608091
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69578595
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.69368118
59* RARA_24833708_ChIP-Seq_LIVER_Mouse0.68515507
60NFYA_21822215_ChIP-Seq_K562_Human0.67106588
61GF1_26923725_Chip-Seq_HPCs_Mouse0.66091576
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66080459
63* BCAT_22108803_ChIP-Seq_LS180_Human0.66036594
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65406827
65GATA1_19941826_ChIP-Seq_K562_Human0.64439146
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63625516
67TP53_18474530_ChIP-ChIP_U2OS_Human0.63557656
68GBX2_23144817_ChIP-Seq_PC3_Human0.63152198
69TP53_16413492_ChIP-PET_HCT116_Human0.62732097
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.62642162
71PHF8_20622853_ChIP-Seq_HELA_Human0.62595032
72CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62534708
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62523503
74AR_20517297_ChIP-Seq_VCAP_Human0.62372343
75GATA2_19941826_ChIP-Seq_K562_Human0.60869508
76IRF8_21731497_ChIP-ChIP_J774_Mouse0.60669973
77RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60358412
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59443688
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.58648553
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.58543941
81CEBPB_22108803_ChIP-Seq_LS180_Human0.58100004
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58057029
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58037441
84GATA3_26560356_Chip-Seq_TH1_Human0.57502404
85OCT4_18555785_Chip-Seq_ESCs_Mouse0.57071793
86CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56902003
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56711479
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56711479
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56704431
90GATA6_25053715_ChIP-Seq_YYC3_Human0.56433672
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.56341026
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.56300783
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.55940008
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55510792
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55314895
96RARB_24833708_ChIP-Seq_LIVER_Mouse0.54591469
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54050300
98IRF1_19129219_ChIP-ChIP_H3396_Human0.53541199
99* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53456305
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53255170
101STAT1_17558387_ChIP-Seq_HELA_Human0.53171478
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.51152854
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.50723831
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49472579
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.49084270
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.49078709
107* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48848160
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48727126
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.48003941
110CBP_21632823_ChIP-Seq_H3396_Human0.47899934
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47715207
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47480449
113* ESET_19884257_ChIP-Seq_ESCs_Mouse0.47045383
114P53_21459846_ChIP-Seq_SAOS-2_Human0.46794659
115SCL_19346495_ChIP-Seq_HPC-7_Human0.45770039
116MYC_19915707_ChIP-ChIP_AK7_Human0.45726893
117EGR1_19032775_ChIP-ChIP_M12_Human0.44636808
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.44525292
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.44368375
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44308096
121* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.44208230
122TAF2_19829295_ChIP-Seq_ESCs_Human0.43710936
123ZNF263_19887448_ChIP-Seq_K562_Human0.43393278
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.42713440
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.42694114
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.42238329
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.42230568
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.41592249
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.41152746
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.40917227
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.40657960
132ERG_20517297_ChIP-Seq_VCAP_Human0.40596207
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.40505190
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.39160372
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.38881335
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.38814387
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.38226798
138* CDX2_22108803_ChIP-Seq_LS180_Human0.36507299
139IRF8_27001747_Chip-Seq_BMDM_Mouse0.36226983
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.35709772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002139_abnormal_hepatobiliary_system7.87854047
2MP0005360_urolithiasis7.40112803
3* MP0005085_abnormal_gallbladder_physiolo6.48521385
4MP0005365_abnormal_bile_salt6.37578566
5MP0008875_abnormal_xenobiotic_pharmacok5.12441317
6MP0003806_abnormal_nucleotide_metabolis4.33990176
7* MP0003252_abnormal_bile_duct3.74530852
8MP0010329_abnormal_lipoprotein_level3.62772583
9MP0009840_abnormal_foam_cell3.29832959
10MP0005083_abnormal_biliary_tract3.21590691
11MP0003195_calcinosis2.89023199
12MP0005332_abnormal_amino_acid2.68834142
13* MP0001666_abnormal_nutrient_absorption2.40852199
14MP0003191_abnormal_cellular_cholesterol2.37078816
15* MP0000609_abnormal_liver_physiology2.23867355
16* MP0002118_abnormal_lipid_homeostasis2.12576880
17MP0004019_abnormal_vitamin_homeostasis2.08535259
18MP0003656_abnormal_erythrocyte_physiolo2.07261507
19* MP0005319_abnormal_enzyme/_coenzyme1.85803107
20MP0001764_abnormal_homeostasis1.79387529
21MP0009697_abnormal_copulation1.77203657
22* MP0003868_abnormal_feces_composition1.68062736
23MP0005584_abnormal_enzyme/coenzyme_acti1.63007968
24MP0005451_abnormal_body_composition1.62684193
25MP0003186_abnormal_redox_activity1.43173536
26MP0003011_delayed_dark_adaptation1.38084173
27MP0009764_decreased_sensitivity_to1.23717434
28MP0009643_abnormal_urine_homeostasis1.21830540
29* MP0000598_abnormal_liver_morphology1.20612794
30MP0005647_abnormal_sex_gland1.17630480
31MP0009763_increased_sensitivity_to1.10406156
32MP0006036_abnormal_mitochondrial_physio1.07045910
33MP0001915_intracranial_hemorrhage1.06623742
34MP0005636_abnormal_mineral_homeostasis1.04589821
35* MP0008469_abnormal_protein_level0.98593169
36MP0003879_abnormal_hair_cell0.97514322
37MP0005670_abnormal_white_adipose0.95735895
38MP0004130_abnormal_muscle_cell0.94531493
39MP0000604_amyloidosis0.91490882
40* MP0009642_abnormal_blood_homeostasis0.90689796
41MP0002254_reproductive_system_inflammat0.89931264
42MP0004147_increased_porphyrin_level0.88953644
43MP0009765_abnormal_xenobiotic_induced0.84772344
44MP0002078_abnormal_glucose_homeostasis0.84197433
45MP0010368_abnormal_lymphatic_system0.83108733
46MP0005187_abnormal_penis_morphology0.83090848
47MP0005408_hypopigmentation0.82929813
48MP0005376_homeostasis/metabolism_phenot0.82661293
49* MP0002138_abnormal_hepatobiliary_system0.80694445
50MP0005334_abnormal_fat_pad0.80220033
51MP0002971_abnormal_brown_adipose0.77437777
52MP0002876_abnormal_thyroid_physiology0.77068592
53MP0006035_abnormal_mitochondrial_morpho0.75906958
54MP0003705_abnormal_hypodermis_morpholog0.74021850
55MP0005084_abnormal_gallbladder_morpholo0.73210374
56MP0005464_abnormal_platelet_physiology0.72667178
57MP0005220_abnormal_exocrine_pancreas0.72377842
58MP0005266_abnormal_metabolism0.71286219
59MP0005535_abnormal_body_temperature0.70066014
60MP0003183_abnormal_peptide_metabolism0.68374845
61MP0003690_abnormal_glial_cell0.63594303
62MP0001661_extended_life_span0.62067398
63MP0002837_dystrophic_cardiac_calcinosis0.59822138
64MP0003724_increased_susceptibility_to0.56155042
65MP0004381_abnormal_hair_follicle0.55253629
66MP0005448_abnormal_energy_balance0.53827413
67MP0001756_abnormal_urination0.51395565
68MP0002822_catalepsy0.51350397
69MP0000639_abnormal_adrenal_gland0.50663315
70MP0005666_abnormal_adipose_tissue0.49999062
71MP0002132_abnormal_respiratory_system0.49358896
72MP0003436_decreased_susceptibility_to0.49065599
73MP0009053_abnormal_anal_canal0.48870554
74MP0002089_abnormal_postnatal_growth/wei0.48652858
75MP0001853_heart_inflammation0.48509457
76MP0005164_abnormal_response_to0.46974938
77MP0005023_abnormal_wound_healing0.45704552
78* MP0003699_abnormal_female_reproductive0.45550997
79MP0008874_decreased_physiological_sensi0.45076160
80MP0008873_increased_physiological_sensi0.44555183
81MP0005167_abnormal_blood-brain_barrier0.44423750
82MP0005395_other_phenotype0.44414513
83MP0003718_maternal_effect0.44048301
84MP0005075_abnormal_melanosome_morpholog0.43173357
85MP0006082_CNS_inflammation0.42983956
86MP0002136_abnormal_kidney_physiology0.42601106
87MP0003953_abnormal_hormone_level0.41926481
88MP0003172_abnormal_lysosome_physiology0.41417895
89MP0004782_abnormal_surfactant_physiolog0.40368672
90MP0003638_abnormal_response/metabolism_0.40256171
91MP0001324_abnormal_eye_pigmentation0.39825741
92MP0004883_abnormal_blood_vessel0.39705667
93MP0008872_abnormal_physiological_respon0.39380862
94MP0000685_abnormal_immune_system0.39140737
95MP0005166_decreased_susceptibility_to0.38768575
96MP0003959_abnormal_lean_body0.38256195
97MP0003303_peritoneal_inflammation0.37777823
98MP0006292_abnormal_olfactory_placode0.37734172
99MP0002282_abnormal_trachea_morphology0.37201035
100MP0002090_abnormal_vision0.36712598
101MP0009115_abnormal_fat_cell0.36126820
102MP0000230_abnormal_systemic_arterial0.35895430
103MP0002269_muscular_atrophy0.35788971
104MP0003075_altered_response_to0.35674179
105MP0005410_abnormal_fertilization0.34920968
106* MP0001845_abnormal_inflammatory_respons0.33623793
107MP0009672_abnormal_birth_weight0.33002626
108MP0003950_abnormal_plasma_membrane0.32473779
109MP0003329_amyloid_beta_deposits0.32165602
110MP0002970_abnormal_white_adipose0.32013374
111MP0000249_abnormal_blood_vessel0.30920360
112MP0000371_diluted_coat_color0.30183500
113MP0000579_abnormal_nail_morphology0.29505731
114MP0002332_abnormal_exercise_endurance0.29238314
115MP0005058_abnormal_lysosome_morphology0.29213080
116MP0001243_abnormal_dermal_layer0.27659317
117MP0005397_hematopoietic_system_phenotyp0.26677747
118MP0001545_abnormal_hematopoietic_system0.26677747
119MP0003890_abnormal_embryonic-extraembry0.25978023
120MP0002168_other_aberrant_phenotype0.25835817
121MP0003646_muscle_fatigue0.25191681
122MP0001800_abnormal_humoral_immune0.24928761
123MP0002419_abnormal_innate_immunity0.24758925
124MP0000920_abnormal_myelination0.23959395
125MP0005197_abnormal_uvea_morphology0.23604458
126MP0009785_altered_susceptibility_to0.23451392
127MP0003633_abnormal_nervous_system0.22861597
128MP0005025_abnormal_response_to0.21891517
129MP0001881_abnormal_mammary_gland0.20697817

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.11652464
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.08220125
3* Intrahepatic cholestasis (HP:0001406)7.03466264
4Prolonged partial thromboplastin time (HP:0003645)6.61303911
5Hypobetalipoproteinemia (HP:0003563)6.34791292
6Xanthomatosis (HP:0000991)6.21450192
7* Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20435087
8Hyperlipoproteinemia (HP:0010980)5.50372233
9Complement deficiency (HP:0004431)5.33570429
10Joint hemorrhage (HP:0005261)4.89440780
11Hypolipoproteinemia (HP:0010981)4.85415256
12Hyperammonemia (HP:0001987)4.61566253
13Epidermoid cyst (HP:0200040)4.53140122
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.47864695
15Abnormality of methionine metabolism (HP:0010901)4.39638423
16Hyperglycinemia (HP:0002154)4.38006629
17Abnormality of the common coagulation pathway (HP:0010990)4.36443638
18Hypoalphalipoproteinemia (HP:0003233)4.32922052
19Ketosis (HP:0001946)4.31851855
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.22100352
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15677974
22Fat malabsorption (HP:0002630)4.08657544
23Hypoglycemic coma (HP:0001325)3.92918881
24Abnormality of pyrimidine metabolism (HP:0004353)3.91672960
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87936975
26Abnormality of complement system (HP:0005339)3.86936386
27Nephritis (HP:0000123)3.81863805
28Conjugated hyperbilirubinemia (HP:0002908)3.80186711
29Abnormality of serine family amino acid metabolism (HP:0010894)3.75627815
30Abnormality of glycine metabolism (HP:0010895)3.75627815
31Hyperglycinuria (HP:0003108)3.75274732
32Abnormality of the intrinsic pathway (HP:0010989)3.74464114
33Hypercholesterolemia (HP:0003124)3.71504789
34Osteomalacia (HP:0002749)3.69730545
35Hyperbilirubinemia (HP:0002904)3.68550486
36Hypochromic microcytic anemia (HP:0004840)3.41454745
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40513831
38Abnormality of fatty-acid metabolism (HP:0004359)3.38732063
39Acanthocytosis (HP:0001927)3.19770737
40Hepatocellular carcinoma (HP:0001402)3.16775451
41Abnormality of serum amino acid levels (HP:0003112)3.15370608
42Ketoacidosis (HP:0001993)3.09292793
43Abnormality of nucleobase metabolism (HP:0010932)3.08173001
44Steatorrhea (HP:0002570)3.04196867
45Spontaneous abortion (HP:0005268)2.92260698
46Metabolic acidosis (HP:0001942)2.92139943
47Reduced antithrombin III activity (HP:0001976)2.90024933
48Delayed CNS myelination (HP:0002188)2.89167748
49Myocardial infarction (HP:0001658)2.86438200
50Systemic lupus erythematosus (HP:0002725)2.80748182
51Poikilocytosis (HP:0004447)2.80484223
52Fair hair (HP:0002286)2.76907530
53Purpura (HP:0000979)2.70418263
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69871415
55Dicarboxylic aciduria (HP:0003215)2.69871415
56Skin nodule (HP:0200036)2.68744205
57Abnormality of purine metabolism (HP:0004352)2.66423022
58Lethargy (HP:0001254)2.65191069
59Pulmonary embolism (HP:0002204)2.64012195
60Cerebral edema (HP:0002181)2.55148894
61Vascular calcification (HP:0004934)2.54946193
62Hypoglycemic seizures (HP:0002173)2.52464567
63Recurrent gram-negative bacterial infections (HP:0005420)2.44052532
64* Abnormal gallbladder morphology (HP:0012437)2.43910213
65Glomerulonephritis (HP:0000099)2.43327835
66* Cholelithiasis (HP:0001081)2.39134333
67Gingival bleeding (HP:0000225)2.37978980
68Mitral stenosis (HP:0001718)2.31324583
69Gout (HP:0001997)2.31151226
70Neonatal onset (HP:0003623)2.24266463
71Renal cortical cysts (HP:0000803)2.24024904
72Cardiovascular calcification (HP:0011915)2.21884200
73Enlarged kidneys (HP:0000105)2.21142956
74Spastic diplegia (HP:0001264)2.20554201
75Amyloidosis (HP:0011034)2.19697834
76Brushfield spots (HP:0001088)2.18460185
77Menorrhagia (HP:0000132)2.16494150
78Abnormality of iron homeostasis (HP:0011031)2.16396060
79Irritability (HP:0000737)2.13812970
80Reticulocytosis (HP:0001923)2.13359842
81Vomiting (HP:0002013)2.11847123
82Sensorimotor neuropathy (HP:0007141)2.10997934
83Generalized aminoaciduria (HP:0002909)2.10529242
84Malnutrition (HP:0004395)2.10334239
85Hyperinsulinemic hypoglycemia (HP:0000825)2.09703248
86Abnormality of transition element cation homeostasis (HP:0011030)2.09165454
87Thrombophlebitis (HP:0004418)2.08801947
88Late onset (HP:0003584)2.08090436
89Esophageal varix (HP:0002040)2.06256151
90Arthropathy (HP:0003040)2.03935409
91Opisthotonus (HP:0002179)2.02385083
92Abnormality of the heme biosynthetic pathway (HP:0010472)1.95521259
93* Abnormality of the gallbladder (HP:0005264)1.94041162
94* Pancreatitis (HP:0001733)1.92821558
95Gangrene (HP:0100758)1.89350981
96Hemorrhage of the eye (HP:0011885)1.88992102
97Abnormality of the Achilles tendon (HP:0005109)1.88263353
98Hyperphosphaturia (HP:0003109)1.87659915
99* Elevated hepatic transaminases (HP:0002910)1.87529005
100Generalized hypopigmentation of hair (HP:0011358)1.86167308
101Rickets (HP:0002748)1.85344139
102Epistaxis (HP:0000421)1.84423255
103Neonatal hypoglycemia (HP:0001998)1.83992302
104Increased serum ferritin (HP:0003281)1.82034737
105Hyperglycemia (HP:0003074)1.80597999
106Proximal tubulopathy (HP:0000114)1.78427197
107Hypertriglyceridemia (HP:0002155)1.77043783
108Hypophosphatemia (HP:0002148)1.76673544
109Abnormality of vitamin metabolism (HP:0100508)1.76364150
110Abnormal tarsal ossification (HP:0008369)1.75905893
111* Elevated alkaline phosphatase (HP:0003155)1.75099660
112Abnormal urine phosphate concentration (HP:0012599)1.74072766
113Nausea (HP:0002018)1.72345497
114Hyperuricemia (HP:0002149)1.70987801
115Increased purine levels (HP:0004368)1.70987801
116Glycosuria (HP:0003076)1.69563294
117Abnormality of urine glucose concentration (HP:0011016)1.69563294
118Hypophosphatemic rickets (HP:0004912)1.69345502
119Joint swelling (HP:0001386)1.67662614
120Lower limb hyperreflexia (HP:0002395)1.57420003
121* Abnormal enzyme/coenzyme activity (HP:0012379)1.57181678
122Increased serum pyruvate (HP:0003542)1.57134088
123Retinal atrophy (HP:0001105)1.56968033
124Bifid scrotum (HP:0000048)1.55738778
125* Abnormality of alkaline phosphatase activity (HP:0004379)1.53836285
126Abnormality of proline metabolism (HP:0010907)1.52023108
127Hydroxyprolinuria (HP:0003080)1.52023108
128Atrioventricular block (HP:0001678)1.46339000
129Blue irides (HP:0000635)1.43460705
130Polycythemia (HP:0001901)1.40740436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.41385895
2SIK13.82290739
3FGFR43.73612386
4TAOK33.58623039
5INSRR3.57841699
6MAP3K133.47069136
7ERN13.39559111
8MAP3K92.58183121
9ARAF2.56585748
10ERBB42.55513187
11PIK3CG2.46893939
12BLK2.37086564
13MAP2K42.32087362
14PKN22.27388351
15CDK122.25181957
16FLT32.22611343
17MAPK112.01838873
18MST1R2.00262851
19TYK21.99615990
20CDK91.70642765
21PINK11.69436426
22MAP2K31.66924150
23NEK91.62925096
24STK31.60580054
25OBSCN1.56023383
26ICK1.49021888
27MAP3K71.46963573
28TBK11.44936950
29PTK61.43321921
30IRAK31.39774585
31MAP3K141.38079010
32PRPF4B1.37267146
33JAK21.35670468
34PRKAA21.29014214
35ABL21.25374583
36TNK21.25363248
37DAPK21.24241030
38PDK11.18242198
39LATS11.17371578
40JAK11.16085895
41MOS1.14468314
42MARK31.13616493
43TRIB31.11625296
44KDR1.09339952
45PRKG11.06246687
46MAPK41.05993342
47STK161.05607832
48KSR21.05588979
49TIE11.03920181
50MAPK121.03509428
51NEK61.01982014
52NME21.01046466
53EIF2AK30.98068978
54MAP3K100.95431145
55MELK0.95010091
56FRK0.92358950
57MAP3K30.91064645
58TGFBR20.90941941
59STK240.89970546
60PIK3CA0.89731191
61TAOK20.88879917
62KIT0.88502827
63NTRK30.88438649
64ERBB20.86955972
65PRKAA10.86075036
66NLK0.84812950
67MAP2K60.83065750
68MAPK150.80543082
69CDK60.80125962
70MAP4K10.77891280
71BRAF0.77319466
72GRK60.76853047
73SYK0.74811264
74PRKACG0.74714885
75STK38L0.72997837
76CDK40.72825127
77CSNK1D0.71625446
78MAP3K110.71501196
79IKBKE0.69888767
80PRKACA0.69613745
81EPHA30.69161500
82GRK10.68505005
83SGK30.67719032
84MAP3K60.67266098
85CDC42BPA0.66233795
86PRKCZ0.64294129
87CAMK1D0.63694196
88ACVR1B0.62565759
89SGK10.62492355
90MAPK70.61654523
91CSF1R0.61399186
92CAMK2G0.59532321
93MAP3K50.59334505
94CSK0.58167549
95SGK20.56321324
96FGR0.54964343
97PRKACB0.53759569
98TRPM70.53324783
99CHUK0.53157298
100FGFR20.52951719
101MAPKAPK30.52767452
102PRKCQ0.52224264
103ZAP700.51431775
104RAF10.50551642
105GSK3A0.49243252
106RPS6KB10.46361975
107SGK2230.46018212
108SGK4940.46018212
109MTOR0.45783559
110JAK30.45680203
111RPS6KA30.43782501
112ZAK0.42912756
113CDK70.41511329
114MUSK0.41477186
115PKN10.41240314
116PIM10.41169644
117RIPK10.37390420
118EPHB10.36041484
119DYRK1B0.35431014
120NUAK10.35231557
121IGF1R0.34982996
122MET0.34332067
123STK40.32845185
124LYN0.32472027
125PHKG20.31777519
126PHKG10.31777519
127IRAK10.31234875
128PRKCB0.31198466
129CSNK1G10.29545140
130PBK0.28041333
131EIF2AK20.27927126
132FGFR30.27891380
133PDPK10.27690296
134MATK0.27420334
135MAP2K10.27150723
136IKBKB0.26566960
137CAMK40.26448404
138PRKCG0.24604948
139MAPK30.24529960
140MAP3K10.23655944
141RET0.23651109
142BTK0.23257392
143EGFR0.23212708
144PRKCA0.22171333

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56163804
2Nitrogen metabolism_Homo sapiens_hsa009103.45849599
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36852419
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28529420
5Arginine biosynthesis_Homo sapiens_hsa002202.98669591
6Complement and coagulation cascades_Homo sapiens_hsa046102.78767067
7Tryptophan metabolism_Homo sapiens_hsa003802.71312913
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68529750
9Fatty acid degradation_Homo sapiens_hsa000712.60542211
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55730144
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47644961
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40376787
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25323358
14Peroxisome_Homo sapiens_hsa041462.14710063
15Butanoate metabolism_Homo sapiens_hsa006502.08212094
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07545928
17Propanoate metabolism_Homo sapiens_hsa006402.01844231
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.92949021
19Chemical carcinogenesis_Homo sapiens_hsa052041.89549875
20PPAR signaling pathway_Homo sapiens_hsa033201.88981117
21Histidine metabolism_Homo sapiens_hsa003401.87323733
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86015812
23Fatty acid metabolism_Homo sapiens_hsa012121.85172047
24Staphylococcus aureus infection_Homo sapiens_hsa051501.81039881
25beta-Alanine metabolism_Homo sapiens_hsa004101.80010408
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78243793
27Caffeine metabolism_Homo sapiens_hsa002321.76439111
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.73833789
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73532575
30Retinol metabolism_Homo sapiens_hsa008301.70404057
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67563421
32Selenocompound metabolism_Homo sapiens_hsa004501.64144128
33Phenylalanine metabolism_Homo sapiens_hsa003601.53700170
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49186225
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47758397
36Tyrosine metabolism_Homo sapiens_hsa003501.41378388
37Starch and sucrose metabolism_Homo sapiens_hsa005001.38825114
38Fatty acid elongation_Homo sapiens_hsa000621.37133905
39Pyruvate metabolism_Homo sapiens_hsa006201.36439046
40* Bile secretion_Homo sapiens_hsa049761.36434304
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32854280
42Sulfur metabolism_Homo sapiens_hsa009201.26069575
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25708733
44* ABC transporters_Homo sapiens_hsa020101.22914408
45Folate biosynthesis_Homo sapiens_hsa007901.19574667
46Biosynthesis of amino acids_Homo sapiens_hsa012301.13452953
47Carbon metabolism_Homo sapiens_hsa012001.12234807
48Fat digestion and absorption_Homo sapiens_hsa049751.10387399
49Steroid biosynthesis_Homo sapiens_hsa001001.06875799
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04734330
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.01733160
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98479768
53Sulfur relay system_Homo sapiens_hsa041220.97172802
54Arginine and proline metabolism_Homo sapiens_hsa003300.96322719
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95950922
56One carbon pool by folate_Homo sapiens_hsa006700.90577306
57Vitamin digestion and absorption_Homo sapiens_hsa049770.89881132
58Lysine degradation_Homo sapiens_hsa003100.88584816
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.76684144
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70683523
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69766806
62Glycerolipid metabolism_Homo sapiens_hsa005610.63496345
63Glutathione metabolism_Homo sapiens_hsa004800.60703418
64Pentose phosphate pathway_Homo sapiens_hsa000300.58489849
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54471767
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51710169
67Metabolic pathways_Homo sapiens_hsa011000.49132296
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40221614
69Other glycan degradation_Homo sapiens_hsa005110.31147173
70Galactose metabolism_Homo sapiens_hsa000520.29864850
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29590071
72Prion diseases_Homo sapiens_hsa050200.28951954
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.28262765
74Insulin resistance_Homo sapiens_hsa049310.27523966
75Linoleic acid metabolism_Homo sapiens_hsa005910.24222437
76Fructose and mannose metabolism_Homo sapiens_hsa000510.20150666
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.18362304
78Glucagon signaling pathway_Homo sapiens_hsa049220.13886472
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06504337
80Renin-angiotensin system_Homo sapiens_hsa046140.05209319
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04244800
82AMPK signaling pathway_Homo sapiens_hsa041520.03569304
83Systemic lupus erythematosus_Homo sapiens_hsa053220.02612211
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2440994
85Allograft rejection_Homo sapiens_hsa05330-0.2419094
86Pyrimidine metabolism_Homo sapiens_hsa00240-0.2345460
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2290398
88Pertussis_Homo sapiens_hsa05133-0.2245142
89FoxO signaling pathway_Homo sapiens_hsa04068-0.2239020
90Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2173911
91B cell receptor signaling pathway_Homo sapiens_hsa04662-0.2163754
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2160287
93Asthma_Homo sapiens_hsa05310-0.2149808
94Circadian rhythm_Homo sapiens_hsa04710-0.2118437
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.2098750
96Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2038542
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1850354
98Sphingolipid metabolism_Homo sapiens_hsa00600-0.1650975
99Lysosome_Homo sapiens_hsa04142-0.1587105
100African trypanosomiasis_Homo sapiens_hsa05143-0.1523012
101Mineral absorption_Homo sapiens_hsa04978-0.1425068
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1421638
103Hepatitis C_Homo sapiens_hsa05160-0.1386614
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1251635
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1185707
106Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1145225
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1066061
108Regulation of autophagy_Homo sapiens_hsa04140-0.0822999
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0663314
110Insulin signaling pathway_Homo sapiens_hsa04910-0.0496022
111Serotonergic synapse_Homo sapiens_hsa04726-0.0397705
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0253177
113Amoebiasis_Homo sapiens_hsa05146-0.0041782

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