ABCB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tetrapyrrole biosynthetic process (GO:0033014)9.07181171
2heme biosynthetic process (GO:0006783)8.86517069
3porphyrin-containing compound metabolic process (GO:0006778)8.21008366
4response to methylmercury (GO:0051597)7.57781549
5heme metabolic process (GO:0042168)7.20746323
6oxygen transport (GO:0015671)6.68518325
7gas transport (GO:0015669)6.30252899
8nuclear pore complex assembly (GO:0051292)6.11700780
9erythrocyte maturation (GO:0043249)5.56813474
10tetrapyrrole metabolic process (GO:0033013)5.54553893
11nuclear pore organization (GO:0006999)5.45674996
12DNA unwinding involved in DNA replication (GO:0006268)5.37849718
13mitotic chromosome condensation (GO:0007076)5.26650047
14negative regulation of erythrocyte differentiation (GO:0045647)5.23841655
15response to lead ion (GO:0010288)5.12201498
16receptor recycling (GO:0001881)5.03305568
17regulation of response to osmotic stress (GO:0047484)4.99144927
18DNA topological change (GO:0006265)4.91126464
19hemoglobin metabolic process (GO:0020027)4.89708253
20very-low-density lipoprotein particle assembly (GO:0034379)4.89664623
21response to insecticide (GO:0017085)4.72805969
22heme transport (GO:0015886)4.65570570
23definitive hemopoiesis (GO:0060216)4.65141577
24erythrocyte development (GO:0048821)4.54324497
25pore complex assembly (GO:0046931)4.43974312
26regulation of RNA export from nucleus (GO:0046831)4.43820460
27lysine metabolic process (GO:0006553)4.43550924
28lysine catabolic process (GO:0006554)4.43550924
29sister chromatid segregation (GO:0000819)4.43162344
30plasma lipoprotein particle assembly (GO:0034377)4.39791321
31mitotic sister chromatid segregation (GO:0000070)4.36875361
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34737466
33L-phenylalanine catabolic process (GO:0006559)4.34737466
34mitotic sister chromatid cohesion (GO:0007064)4.32296259
35cysteine metabolic process (GO:0006534)4.28731509
36DNA synthesis involved in DNA repair (GO:0000731)4.27306639
37import into cell (GO:0098657)4.15716517
38protein-lipid complex assembly (GO:0065005)4.15011229
39DNA replication initiation (GO:0006270)4.12590512
40L-phenylalanine metabolic process (GO:0006558)4.12318306
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.12318306
42pigment biosynthetic process (GO:0046148)4.09112892
43L-alpha-amino acid transmembrane transport (GO:1902475)4.05903710
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.91805008
45regulation of histone H3-K9 methylation (GO:0051570)3.86395859
46water-soluble vitamin biosynthetic process (GO:0042364)3.80469610
47cofactor biosynthetic process (GO:0051188)3.77019617
48response to arsenic-containing substance (GO:0046685)3.75302273
49meiotic chromosome segregation (GO:0045132)3.67149706
50erythrocyte differentiation (GO:0030218)3.63743126
51alpha-linolenic acid metabolic process (GO:0036109)3.61563796
52regulation of nucleobase-containing compound transport (GO:0032239)3.60195984
53DNA strand elongation involved in DNA replication (GO:0006271)3.57277798
54megakaryocyte development (GO:0035855)3.55483749
55pigment metabolic process (GO:0042440)3.54023519
56protein localization to chromosome, centromeric region (GO:0071459)3.52992438
57DNA strand elongation (GO:0022616)3.52546939
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41183041
59innate immune response in mucosa (GO:0002227)3.40058695
60glyoxylate metabolic process (GO:0046487)3.39945101
61aspartate family amino acid catabolic process (GO:0009068)3.38341129
62aromatic amino acid family catabolic process (GO:0009074)3.34185811
63mitotic nuclear envelope disassembly (GO:0007077)3.33715459
64DNA replication checkpoint (GO:0000076)3.32573487
65myeloid cell development (GO:0061515)3.32278044
66iron ion import (GO:0097286)3.31546160
67proline biosynthetic process (GO:0006561)3.28773720
68negative regulation of fibrinolysis (GO:0051918)3.25237699
69ethanol oxidation (GO:0006069)3.23324802
70embryonic process involved in female pregnancy (GO:0060136)3.21952675
71regulation of erythrocyte differentiation (GO:0045646)3.20976399
72protein autoprocessing (GO:0016540)3.19211967
73nuclear envelope disassembly (GO:0051081)3.18554465
74membrane disassembly (GO:0030397)3.18554465
75antibacterial humoral response (GO:0019731)3.16929479
76acetyl-CoA metabolic process (GO:0006084)3.16409458
77telomere maintenance via semi-conservative replication (GO:0032201)3.15623111
78cofactor catabolic process (GO:0051187)3.13188339
79chromosome condensation (GO:0030261)3.11565226
80DNA duplex unwinding (GO:0032508)3.11343138
81platelet formation (GO:0030220)3.10369328
82regulation of lipoprotein metabolic process (GO:0050746)3.08033471
83iron coordination entity transport (GO:1901678)3.06103241
84granulocyte differentiation (GO:0030851)3.05072250
85DNA conformation change (GO:0071103)3.03479349
86mitotic recombination (GO:0006312)3.03146008
87DNA geometric change (GO:0032392)3.02605069
88plasma lipoprotein particle organization (GO:0071827)3.01774578
89positive regulation of granulocyte differentiation (GO:0030854)3.00006723
90telomere maintenance via recombination (GO:0000722)2.97879869
91short-chain fatty acid metabolic process (GO:0046459)2.97375349
92regulation of translational fidelity (GO:0006450)2.96568817
93protein-lipid complex subunit organization (GO:0071825)2.96290443
94regulation of fibrinolysis (GO:0051917)2.94031743
95bile acid biosynthetic process (GO:0006699)2.92102605
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91747401
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91747401
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.91747401
99regulation of cholesterol metabolic process (GO:0090181)2.89255824
100monoubiquitinated protein deubiquitination (GO:0035520)2.88094553
101high-density lipoprotein particle remodeling (GO:0034375)2.87855877
102fatty acid beta-oxidation (GO:0006635)2.86821327
103fatty acid oxidation (GO:0019395)2.86734408
104hematopoietic stem cell differentiation (GO:0060218)2.86610094
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.84697705
106serine family amino acid metabolic process (GO:0009069)2.84512493
107antimicrobial humoral response (GO:0019730)2.83892393
108sulfur amino acid catabolic process (GO:0000098)2.83708586
109regulation of sister chromatid cohesion (GO:0007063)2.83067901
1103-UTR-mediated mRNA stabilization (GO:0070935)2.82698480
111chromosome segregation (GO:0007059)2.79966859
1122-oxoglutarate metabolic process (GO:0006103)2.79906786
113glycine metabolic process (GO:0006544)2.79197826
114formation of translation preinitiation complex (GO:0001731)2.78946056
115N-terminal protein amino acid acetylation (GO:0006474)2.78909896
116response to dexamethasone (GO:0071548)2.78657379
117cholesterol efflux (GO:0033344)2.78649435
118lipid oxidation (GO:0034440)2.78375831
119DNA packaging (GO:0006323)2.78001691
120intestinal cholesterol absorption (GO:0030299)2.77677619
121regulation of triglyceride catabolic process (GO:0010896)2.77325218
122amino-acid betaine metabolic process (GO:0006577)2.77234490
123response to mercury ion (GO:0046689)2.76888955
124cofactor metabolic process (GO:0051186)2.76738732
125acyl-CoA biosynthetic process (GO:0071616)2.76628263
126thioester biosynthetic process (GO:0035384)2.76628263
127phospholipid efflux (GO:0033700)2.76614460
128plasma lipoprotein particle clearance (GO:0034381)2.75465139
129positive regulation of chromosome segregation (GO:0051984)2.74858644
130tricarboxylic acid metabolic process (GO:0072350)2.74581712
131kynurenine metabolic process (GO:0070189)2.74552462
132regulation of cholesterol biosynthetic process (GO:0045540)2.72994675
133protein export from nucleus (GO:0006611)2.72608780
134cellular response to dexamethasone stimulus (GO:0071549)2.70398162
135fatty acid catabolic process (GO:0009062)2.69981073
136regulation of cholesterol homeostasis (GO:2000188)2.69311020
137deoxyribonucleotide biosynthetic process (GO:0009263)2.68312641
138kinetochore organization (GO:0051383)2.68035677
139regulation of histone H3-K27 methylation (GO:0061085)2.67804287
140glutamate metabolic process (GO:0006536)2.67608649
141vitamin biosynthetic process (GO:0009110)2.65042476
142folic acid-containing compound biosynthetic process (GO:0009396)2.64902420
143positive regulation of B cell differentiation (GO:0045579)2.64442573
144negative regulation of fatty acid biosynthetic process (GO:0045717)2.64375482
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61768754
146protein localization to kinetochore (GO:0034501)2.61605086
147mucosal immune response (GO:0002385)2.61211475
148purine-containing compound salvage (GO:0043101)2.61185531
149regulation of centriole replication (GO:0046599)2.58923882
150poly(A)+ mRNA export from nucleus (GO:0016973)2.58298517
151positive regulation of erythrocyte differentiation (GO:0045648)2.58142964
152reverse cholesterol transport (GO:0043691)2.57851919
153regulation of DNA endoreduplication (GO:0032875)2.57428382
154homocysteine metabolic process (GO:0050667)2.56980386
155valine metabolic process (GO:0006573)2.56628320
156V(D)J recombination (GO:0033151)2.56245849
157pyridine-containing compound biosynthetic process (GO:0072525)2.55469597
158cholesterol biosynthetic process (GO:0006695)2.55387322
159DNA ligation (GO:0006266)2.55287037
160carnitine metabolic process (GO:0009437)2.55242852
161serine family amino acid biosynthetic process (GO:0009070)2.53597875
162positive regulation of histone methylation (GO:0031062)2.53284467
163protein carboxylation (GO:0018214)2.52713279
164peptidyl-glutamic acid carboxylation (GO:0017187)2.52713279
165alpha-amino acid catabolic process (GO:1901606)2.52645585
166imidazole-containing compound metabolic process (GO:0052803)2.52057743
167serine family amino acid catabolic process (GO:0009071)2.51575175
168regulation of histone H3-K4 methylation (GO:0051569)2.50690690
169urea cycle (GO:0000050)2.49969037
170urea metabolic process (GO:0019627)2.49969037
171monocarboxylic acid catabolic process (GO:0072329)2.49900971
172positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48592207
173RNA stabilization (GO:0043489)2.47390534
174mRNA stabilization (GO:0048255)2.47390534
175organ or tissue specific immune response (GO:0002251)2.45479708
176protoporphyrinogen IX metabolic process (GO:0046501)13.9267705
177protoporphyrinogen IX biosynthetic process (GO:0006782)12.4031890
178porphyrin-containing compound biosynthetic process (GO:0006779)10.0758661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.78837490
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.77590982
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.56154798
4* GATA1_19941826_ChIP-Seq_K562_Human4.25774755
5* GATA1_22025678_ChIP-Seq_K562_Human4.08864960
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.89768301
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60869487
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.56813590
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45630682
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.44059238
11* GATA1_19941827_ChIP-Seq_MEL_Mouse3.41748310
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.03910783
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.93043841
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74291352
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.70733039
16KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.60647699
17* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.60284125
18E2F7_22180533_ChIP-Seq_HELA_Human2.48963117
19ZNF263_19887448_ChIP-Seq_K562_Human2.40705353
20SCL_19346495_ChIP-Seq_HPC-7_Human2.32178490
21* GATA2_19941826_ChIP-Seq_K562_Human2.30545289
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17710592
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02246082
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97608359
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94106959
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93970212
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82884302
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76700399
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73702197
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72446284
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69959279
32CLOCK_20551151_ChIP-Seq_293T_Human1.55774637
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53726443
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52350330
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50802897
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46244348
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46065648
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45938915
39DCP1A_22483619_ChIP-Seq_HELA_Human1.45910994
40TFEB_21752829_ChIP-Seq_HELA_Human1.45870827
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44261125
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42371219
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40607278
44* NCOR1_26117541_ChIP-Seq_K562_Human1.38734646
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30618879
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30258441
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22293245
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21318118
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21295246
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21029125
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19884079
52AR_21909140_ChIP-Seq_LNCAP_Human1.19516669
53* MAF_26560356_Chip-Seq_TH1_Human1.17606880
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.17106281
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16952380
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16280128
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15733420
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15634867
59VDR_24763502_ChIP-Seq_THP-1_Human1.15349270
60SPI1_23547873_ChIP-Seq_NB4_Human1.14898575
61MYB_26560356_Chip-Seq_TH1_Human1.14879936
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14219764
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14096849
64MYC_22102868_ChIP-Seq_BL_Human1.14028770
65* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11643278
66TCF7_22412390_ChIP-Seq_EML_Mouse1.11501371
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10907656
68VDR_21846776_ChIP-Seq_THP-1_Human1.09307613
69* FOXP3_21729870_ChIP-Seq_TREG_Human1.09089613
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08348089
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08285958
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07981351
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07345201
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06070817
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05825518
76CIITA_25753668_ChIP-Seq_RAJI_Human1.05387111
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04634289
78VDR_23849224_ChIP-Seq_CD4+_Human1.04476657
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.04323813
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.04183840
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03812989
82* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03615664
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03161012
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02704431
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02565901
86KDM5A_27292631_Chip-Seq_BREAST_Human1.02445355
87TTF2_22483619_ChIP-Seq_HELA_Human1.01589999
88ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01091907
89MYB_26560356_Chip-Seq_TH2_Human1.00536627
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.99760571
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99393281
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98536728
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98397457
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98330089
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98150149
96GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97306401
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97209298
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96693797
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96176481
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95640746
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95339050
102* ATF3_27146783_Chip-Seq_COLON_Human0.94931513
103CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94288858
104* GATA6_25053715_ChIP-Seq_YYC3_Human0.94262285
105E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94096739
106P68_20966046_ChIP-Seq_HELA_Human0.93820476
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92965529
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92822125
109ELK1_19687146_ChIP-ChIP_HELA_Human0.92750591
110BCOR_27268052_Chip-Seq_Bcells_Human0.92617402
111EST1_17652178_ChIP-ChIP_JURKAT_Human0.92106715
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90997339
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89928679
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88088005
115* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86724563
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86615874
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86574115
118* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86002281
119* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85294442
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85079690
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84472389
122CREB1_26743006_Chip-Seq_LNCaP_Human0.84179377
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84021786
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84021271
125* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84011437
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.83997666
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83254351
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83249738
129MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82716305
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82594894
131* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81432282
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81249748
133GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80391332
134* CHD1_26751641_Chip-Seq_LNCaP_Human0.80369861
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79786277
136XRN2_22483619_ChIP-Seq_HELA_Human0.79624970
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79275020
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78665486
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.78333515
140* E2F1_21310950_ChIP-Seq_MCF-7_Human0.77683648
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77361328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.08596324
2MP0004147_increased_porphyrin_level7.60143208
3MP0002139_abnormal_hepatobiliary_system4.67048225
4MP0005083_abnormal_biliary_tract4.23317097
5MP0005360_urolithiasis3.96320246
6MP0008057_abnormal_DNA_replication3.68672702
7MP0003806_abnormal_nucleotide_metabolis3.64213120
8MP0005085_abnormal_gallbladder_physiolo3.47937892
9MP0005365_abnormal_bile_salt3.03799262
10MP0010094_abnormal_chromosome_stability3.01863361
11MP0002009_preneoplasia2.79549537
12MP0002396_abnormal_hematopoietic_system2.61327022
13MP0009840_abnormal_foam_cell2.26982424
14MP0004957_abnormal_blastocyst_morpholog2.26038233
15MP0009697_abnormal_copulation2.20759627
16MP0005636_abnormal_mineral_homeostasis2.20753321
17MP0003077_abnormal_cell_cycle2.19330771
18MP0008875_abnormal_xenobiotic_pharmacok2.19133600
19MP0010329_abnormal_lipoprotein_level2.07803577
20MP0006036_abnormal_mitochondrial_physio2.06307584
21MP0002877_abnormal_melanocyte_morpholog2.05607354
22MP0003693_abnormal_embryo_hatching1.95433606
23MP0004808_abnormal_hematopoietic_stem1.89745935
24MP0010352_gastrointestinal_tract_polyps1.84106214
25MP0001666_abnormal_nutrient_absorption1.82975261
26MP0002837_dystrophic_cardiac_calcinosis1.81457228
27MP0003252_abnormal_bile_duct1.79696913
28MP0003195_calcinosis1.76857536
29MP0008058_abnormal_DNA_repair1.73027726
30MP0000609_abnormal_liver_physiology1.67656419
31MP0003186_abnormal_redox_activity1.66187539
32MP0003303_peritoneal_inflammation1.64382455
33MP0005076_abnormal_cell_differentiation1.58487138
34MP0002166_altered_tumor_susceptibility1.58364870
35MP0002118_abnormal_lipid_homeostasis1.57892824
36MP0009278_abnormal_bone_marrow1.54679984
37MP0005332_abnormal_amino_acid1.49025161
38MP0003111_abnormal_nucleus_morphology1.48014222
39MP0004043_abnormal_pH_regulation1.44267713
40MP0001661_extended_life_span1.42982835
41MP0008775_abnormal_heart_ventricle1.42708605
42MP0002398_abnormal_bone_marrow1.38259372
43MP0008007_abnormal_cellular_replicative1.36535263
44MP0000350_abnormal_cell_proliferation1.36025271
45MP0003329_amyloid_beta_deposits1.33254895
46MP0006054_spinal_hemorrhage1.29438763
47MP0005319_abnormal_enzyme/_coenzyme1.28995454
48MP0009643_abnormal_urine_homeostasis1.26942920
49MP0001545_abnormal_hematopoietic_system1.25702592
50MP0005397_hematopoietic_system_phenotyp1.25702592
51MP0001697_abnormal_embryo_size1.24556385
52MP0002722_abnormal_immune_system1.23497137
53MP0004215_abnormal_myocardial_fiber1.20695827
54MP0002086_abnormal_extraembryonic_tissu1.20660845
55MP0001672_abnormal_embryogenesis/_devel1.20195132
56MP0005380_embryogenesis_phenotype1.20195132
57MP0003984_embryonic_growth_retardation1.20095425
58MP0003705_abnormal_hypodermis_morpholog1.19695865
59MP0000747_muscle_weakness1.19224889
60MP0003763_abnormal_thymus_physiology1.18139735
61MP0000749_muscle_degeneration1.17668027
62MP0002078_abnormal_glucose_homeostasis1.17266252
63MP0000003_abnormal_adipose_tissue1.16105302
64MP0002088_abnormal_embryonic_growth/wei1.15043311
65MP0000689_abnormal_spleen_morphology1.14319218
66MP0000703_abnormal_thymus_morphology1.13276656
67MP0003191_abnormal_cellular_cholesterol1.12118090
68MP0000598_abnormal_liver_morphology1.10847440
69MP0000490_abnormal_crypts_of1.10025211
70MP0001764_abnormal_homeostasis1.08996264
71MP0008932_abnormal_embryonic_tissue1.08546153
72MP0004130_abnormal_muscle_cell1.07584094
73MP0003300_gastrointestinal_ulcer1.07406396
74MP0003786_premature_aging1.07066246
75MP0005584_abnormal_enzyme/coenzyme_acti1.04930573
76MP0009333_abnormal_splenocyte_physiolog1.04922356
77MP0002006_tumorigenesis1.02719863
78MP0002971_abnormal_brown_adipose1.00538769
79MP0005501_abnormal_skin_physiology0.99567643
80MP0008995_early_reproductive_senescence0.99480903
81MP0009765_abnormal_xenobiotic_induced0.99447926
82MP0002019_abnormal_tumor_incidence0.97443767
83MP0002429_abnormal_blood_cell0.96054023
84MP0002269_muscular_atrophy0.95948616
85MP0005058_abnormal_lysosome_morphology0.95197836
86MP0002970_abnormal_white_adipose0.94264337
87MP0003868_abnormal_feces_composition0.92557663
88MP0002132_abnormal_respiratory_system0.91419187
89MP0010234_abnormal_vibrissa_follicle0.90700954
90MP0005621_abnormal_cell_physiology0.89777224
91MP0005330_cardiomyopathy0.88922847
92MP0003172_abnormal_lysosome_physiology0.88483050
93MP0005464_abnormal_platelet_physiology0.87215793
94MP0004185_abnormal_adipocyte_glucose0.87013525
95MP0005266_abnormal_metabolism0.84120146
96MP0005334_abnormal_fat_pad0.83541418
97MP0004264_abnormal_extraembryonic_tissu0.82564915
98MP0006035_abnormal_mitochondrial_morpho0.82384604
99MP0003221_abnormal_cardiomyocyte_apopto0.81637347
100MP0003566_abnormal_cell_adhesion0.80716479
101MP0008770_decreased_survivor_rate0.80648374
102MP0005375_adipose_tissue_phenotype0.80634467
103MP0004084_abnormal_cardiac_muscle0.80538965
104MP0008872_abnormal_physiological_respon0.79611839
105MP0000015_abnormal_ear_pigmentation0.78718285
106MP0009672_abnormal_birth_weight0.75451684
107MP0009931_abnormal_skin_appearance0.75071334
108MP0000858_altered_metastatic_potential0.74779860
109MP0005384_cellular_phenotype0.74744539
110MP0010307_abnormal_tumor_latency0.74273104
111MP0004036_abnormal_muscle_relaxation0.73890239
112MP0009763_increased_sensitivity_to0.73617945
113MP0000604_amyloidosis0.72816079
114MP0005220_abnormal_exocrine_pancreas0.72704012
115MP0001915_intracranial_hemorrhage0.71987235
116MP0005535_abnormal_body_temperature0.71796224
117MP0001191_abnormal_skin_condition0.69815743
118MP0005448_abnormal_energy_balance0.69113139
119MP0002405_respiratory_system_inflammati0.67449268
120MP0004947_skin_inflammation0.67077962
121MP0005666_abnormal_adipose_tissue0.65810588
122MP0009642_abnormal_blood_homeostasis0.65679493
123MP0005376_homeostasis/metabolism_phenot0.65549093
124MP0001529_abnormal_vocalization0.63893423
125MP0001730_embryonic_growth_arrest0.62867391
126MP0002972_abnormal_cardiac_muscle0.62635136
127MP0000716_abnormal_immune_system0.62379579
128MP0002084_abnormal_developmental_patter0.61983533
129MP0001835_abnormal_antigen_presentation0.61541552
130MP0005451_abnormal_body_composition0.60703522
131MP0003959_abnormal_lean_body0.60206431
132MP0000685_abnormal_immune_system0.60061518
133MP0001944_abnormal_pancreas_morphology0.59924816
134MP0000920_abnormal_myelination0.59772346
135MP0000358_abnormal_cell_content/0.59457518
136MP0005452_abnormal_adipose_tissue0.59060329
137MP0002095_abnormal_skin_pigmentation0.58137513
138MP0002085_abnormal_embryonic_tissue0.58078125
139MP0001756_abnormal_urination0.57988295
140MP0002060_abnormal_skin_morphology0.57678136
141MP0002138_abnormal_hepatobiliary_system0.57359540
142MP0008260_abnormal_autophagy0.57252353
143MP0003890_abnormal_embryonic-extraembry0.57246481
144MP0003453_abnormal_keratinocyte_physiol0.56575110
145MP0002080_prenatal_lethality0.56400522
146MP0003828_pulmonary_edema0.55740710
147MP0005408_hypopigmentation0.54413557
148MP0003943_abnormal_hepatobiliary_system0.54388633
149MP0004087_abnormal_muscle_fiber0.54048287
150MP0005620_abnormal_muscle_contractility0.52215437
151MP0002229_neurodegeneration0.51855063
152MP0004197_abnormal_fetal_growth/weight/0.50783231
153MP0003632_abnormal_nervous_system0.50211758
154MP0004019_abnormal_vitamin_homeostasis0.50117992
155MP0000313_abnormal_cell_death0.49346669
156MP0010630_abnormal_cardiac_muscle0.49092844
157MP0000013_abnormal_adipose_tissue0.49074276
158MP0000465_gastrointestinal_hemorrhage0.48897199
159MP0001765_abnormal_ion_homeostasis0.48191260
160MP0001544_abnormal_cardiovascular_syste0.47745224

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)8.48028715
2Reticulocytosis (HP:0001923)7.06840709
3Cholelithiasis (HP:0001081)5.62245435
4Hypochromic microcytic anemia (HP:0004840)5.61863678
5Hyperbilirubinemia (HP:0002904)5.56386079
6Abnormal gallbladder morphology (HP:0012437)5.45425644
7Diaphragmatic weakness (HP:0009113)4.84590574
8Abnormal hemoglobin (HP:0011902)4.64895436
9Abnormality of reticulocytes (HP:0004312)4.42794441
10Polycythemia (HP:0001901)4.28041322
11Paralysis (HP:0003470)4.07914504
12Abnormality of the gallbladder (HP:0005264)3.80187092
13Hypoglycemic coma (HP:0001325)3.78883267
14Cholecystitis (HP:0001082)3.60229713
15Abnormal gallbladder physiology (HP:0012438)3.60229713
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57965545
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51780418
18Intrahepatic cholestasis (HP:0001406)3.44466316
19Chromsome breakage (HP:0040012)3.39565755
20Xanthomatosis (HP:0000991)3.39185373
21Osteomalacia (HP:0002749)3.32248033
22Insomnia (HP:0100785)3.28901843
23Petechiae (HP:0000967)3.17601759
24Ileus (HP:0002595)3.11097540
25Deep venous thrombosis (HP:0002625)3.06802135
26Acute myeloid leukemia (HP:0004808)2.88353702
27Hepatocellular carcinoma (HP:0001402)2.85858585
28Abnormality of the fingertips (HP:0001211)2.85052765
29Microcytic anemia (HP:0001935)2.82113910
30Hyperinsulinemic hypoglycemia (HP:0000825)2.79394269
31Tetraparesis (HP:0002273)2.78593338
32Ketosis (HP:0001946)2.75975210
33Increased serum ferritin (HP:0003281)2.67530078
34Abnormal platelet volume (HP:0011876)2.66904875
35Global brain atrophy (HP:0002283)2.66704813
36Pallor (HP:0000980)2.61984014
37Hypoglycemic seizures (HP:0002173)2.60651198
38Abnormality of transition element cation homeostasis (HP:0011030)2.59770061
39Abnormality of iron homeostasis (HP:0011031)2.57700836
40Hypochromic anemia (HP:0001931)2.57276922
41Long clavicles (HP:0000890)2.52850051
42Hypobetalipoproteinemia (HP:0003563)2.51160670
43Brushfield spots (HP:0001088)2.51053866
44Pancreatic islet-cell hyperplasia (HP:0004510)2.50375366
45Toxemia of pregnancy (HP:0100603)2.50001345
46Cutaneous photosensitivity (HP:0000992)2.49955936
47Orthostatic hypotension (HP:0001278)2.49054600
48Ketoacidosis (HP:0001993)2.48655851
49Hyperlipoproteinemia (HP:0010980)2.48237104
5011 pairs of ribs (HP:0000878)2.48107568
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46225434
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45833758
53Confusion (HP:0001289)2.37463748
54Hyperammonemia (HP:0001987)2.33911410
55Status epilepticus (HP:0002133)2.32324720
56Hypertensive crisis (HP:0100735)2.27562614
57Abnormality of glycine metabolism (HP:0010895)2.26414022
58Abnormality of serine family amino acid metabolism (HP:0010894)2.26414022
59Metabolic acidosis (HP:0001942)2.26122008
60Myelodysplasia (HP:0002863)2.21022971
61Myoglobinuria (HP:0002913)2.19971518
62Bilateral sensorineural hearing impairment (HP:0008619)2.19967250
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.19287752
64Birth length less than 3rd percentile (HP:0003561)2.19089496
65Ankyloglossia (HP:0010296)2.16983542
66Prolonged partial thromboplastin time (HP:0003645)2.15408791
67Abnormality of fatty-acid metabolism (HP:0004359)2.14357592
68Hypolipoproteinemia (HP:0010981)2.14057903
69Short middle phalanx of the 5th finger (HP:0004220)2.11234421
70Abnormality of the pancreatic islet cells (HP:0006476)2.09251267
71Abnormality of endocrine pancreas physiology (HP:0012093)2.09251267
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07706536
73Dicarboxylic aciduria (HP:0003215)2.07706536
74Generalized hyperpigmentation (HP:0007440)2.07613272
75Abnormality of the intrinsic pathway (HP:0010989)2.07046001
76Nausea (HP:0002018)2.05690223
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05575246
78Hyponatremia (HP:0002902)2.05264173
79Hyperglycinemia (HP:0002154)2.05141532
80Cafe-au-lait spot (HP:0000957)2.04471097
81Metaphyseal cupping (HP:0003021)2.03871643
82Generalized aminoaciduria (HP:0002909)2.03575783
83Abnormality of chromosome stability (HP:0003220)2.03356014
84Severe muscular hypotonia (HP:0006829)2.03345872
85Hyperglycinuria (HP:0003108)2.03274546
86Abnormal number of erythroid precursors (HP:0012131)2.03028980
87Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02781469
88Heterotopia (HP:0002282)2.02333481
89Hypoalphalipoproteinemia (HP:0003233)2.01542437
90Abnormal foot bone ossification (HP:0010675)2.00202474
91Poikilocytosis (HP:0004447)10.3446978
92Abnormality of the heme biosynthetic pathway (HP:0010472)10.1239609
93Recurrent viral infections (HP:0004429)1.97575382
94Back pain (HP:0003418)1.95200371
95Abnormality of cells of the erythroid lineage (HP:0012130)1.95094309
96Abnormality of the common coagulation pathway (HP:0010990)1.94905342
97Hyperglycemia (HP:0003074)1.93223985
98Abnormality of chromosome segregation (HP:0002916)1.92068677
99Papillary thyroid carcinoma (HP:0002895)1.91273317
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89602299
101Autoimmune hemolytic anemia (HP:0001890)1.89582849
102Symptomatic seizures (HP:0011145)1.89413758
103Deep philtrum (HP:0002002)1.89168148
104Impaired platelet aggregation (HP:0003540)1.87251529
105Abnormal platelet function (HP:0011869)1.87251529
106Prolonged bleeding time (HP:0003010)1.87162195
107Cortical visual impairment (HP:0100704)1.85797305
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83269527
109Colitis (HP:0002583)1.81417117
110Sandal gap (HP:0001852)1.80798991
111Complement deficiency (HP:0004431)1.80731766
112Epidermoid cyst (HP:0200040)1.80522846
113Fatigue (HP:0012378)1.79427844
114Abnormality of methionine metabolism (HP:0010901)1.78898578
115Progressive external ophthalmoplegia (HP:0000590)1.78273401
116Spastic paraparesis (HP:0002313)1.76371772
117Missing ribs (HP:0000921)1.74595761
118Abnormality of sodium homeostasis (HP:0010931)1.73560387
119Hypoparathyroidism (HP:0000829)1.73531854
120Gastrointestinal infarctions (HP:0005244)1.72836896
121Hemiparesis (HP:0001269)1.72777462
122Cerebral palsy (HP:0100021)1.72722111
123Cortical dysplasia (HP:0002539)1.70955377
124Ragged-red muscle fibers (HP:0003200)1.70118251
125Abnormality of the preputium (HP:0100587)1.69284826
126Osteomyelitis (HP:0002754)1.69099836
127Increased mean platelet volume (HP:0011877)1.66250843
128Vomiting (HP:0002013)1.65257381
129Thyroid carcinoma (HP:0002890)1.65030723
130Multiple enchondromatosis (HP:0005701)1.64504027
131Limb hypertonia (HP:0002509)1.64021482
132Epistaxis (HP:0000421)1.63689546
133Lower limb hyperreflexia (HP:0002395)1.63235991
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63049769
135Abnormality of oral frenula (HP:0000190)1.61499143
136Nonimmune hydrops fetalis (HP:0001790)1.61252065
137Insidious onset (HP:0003587)1.60844675
138Termporal pattern (HP:0011008)1.60844675
139Acute lymphatic leukemia (HP:0006721)1.60654700
140Hypercholesterolemia (HP:0003124)1.60225181
141Thrombocytosis (HP:0001894)1.60218882
142Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60178070
143Late onset (HP:0003584)1.59979033
144Dysmetric saccades (HP:0000641)1.59707494
145Abnormal large intestine physiology (HP:0012700)1.59512304
146Severe Myopia (HP:0011003)1.59358017
147Progressive muscle weakness (HP:0003323)1.59219682
148Duodenal stenosis (HP:0100867)1.58490680
149Small intestinal stenosis (HP:0012848)1.58490680
150Bowel incontinence (HP:0002607)1.58135195
151Abnormality of the calcaneus (HP:0008364)1.57934166
152Abnormality of nail color (HP:0100643)1.57563851
153Relative macrocephaly (HP:0004482)1.56854518
154Septate vagina (HP:0001153)1.53770873
155Neoplasm of the small intestine (HP:0100833)1.53312041
156Spontaneous hematomas (HP:0007420)1.52711920
157Viral hepatitis (HP:0006562)1.51162079
158Biliary tract neoplasm (HP:0100574)1.50943986
159Macroorchidism (HP:0000053)1.50175887
160Abnormality of the thoracic spine (HP:0100711)1.49839767
161Bladder carcinoma (HP:0002862)1.46448026
162Bladder neoplasm (HP:0009725)1.46448026
163Leiomyosarcoma (HP:0100243)1.46173994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.57174872
2PRPF4B4.07706278
3TAOK33.57851897
4BCKDK3.14120876
5STK43.06942681
6TRIB32.75025373
7MAP2K32.54440239
8PKN22.46048142
9SCYL22.43083364
10CLK12.30798033
11RIPK41.88392877
12EEF2K1.88196230
13PLK41.85179745
14WEE11.78148032
15WNK41.77586143
16INSRR1.76418794
17BRSK11.74011600
18MAP3K101.73553203
19DYRK1B1.70929032
20TLK11.66366618
21MAPK111.60548910
22FLT31.54772050
23SMG11.52346312
24ERN11.48478778
25MAPKAPK51.47027714
26MAP3K141.36131339
27RAF11.35931398
28CDC71.29337649
29IRAK31.28648322
30BRD41.27100668
31MET1.26192922
32KSR11.25512538
33JAK21.21176700
34MAP3K61.20278039
35DYRK31.18983486
36AURKA1.15455410
37MAP3K81.15111979
38CCNB11.14028914
39TTN1.11630905
40BRSK21.10387090
41BRAF1.10223256
42TAOK21.09682265
43SRPK11.07230590
44NEK11.06463458
45SIK11.06414935
46PRKAA11.05742414
47EIF2AK31.04961994
48STK101.02414607
49CDK61.02368441
50PTK21.02142321
51ZAK1.01773031
52PRKAA21.01034494
53BUB10.98912691
54NEK90.97474965
55UHMK10.96803127
56BMX0.96542547
57MAP2K20.95280671
58PIM10.94791198
59RPS6KA40.91137733
60RPS6KA50.89999276
61ERBB20.89945841
62LRRK20.85913411
63NME20.85039681
64GRK60.83491678
65ATR0.83371508
66MST40.83030890
67TAOK10.82072015
68YES10.81858193
69MAP3K130.81781064
70MTOR0.81073517
71MAP2K10.79323606
72PTK60.78401006
73PLK10.78312833
74PASK0.78091614
75PRKACG0.77438273
76NEK20.77227340
77MAPKAPK30.77100931
78PAK20.75764815
79WNK10.74333008
80MAP2K40.74170326
81MAP3K10.73610003
82PDPK10.73446355
83STK30.73329800
84CDK70.72974515
85SGK4940.72944830
86SGK2230.72944830
87MAP3K20.72717072
88SGK30.72650834
89HIPK20.72422544
90STK390.72332179
91MAPK150.71822575
92TTK0.70930599
93NTRK10.69773700
94FGFR30.69644309
95MARK30.68727540
96BMPR20.68281668
97EPHB10.67961085
98CDC42BPA0.67444617
99VRK10.66973818
100PLK30.65646564
101CHEK20.65461960
102MKNK10.65078379
103TEC0.62498291
104RPS6KB20.61238494
105PAK30.61223112
106CAMK1D0.60301767
107AURKB0.59892172
108CDK40.59615251
109MAP3K110.59494499
110TRPM70.58864808
111PKN10.58651156
112BTK0.58027292
113CHEK10.57673958
114PDGFRA0.56575778
115PRKDC0.56245925
116ABL20.55640902
117RET0.55158534
118RPS6KL10.54117375
119RPS6KC10.54117375
120CAMK1G0.53246993
121PRKD10.52201069
122AKT20.52039890
123RPS6KB10.51761265
124RPS6KA20.50317625
125RPS6KA60.46846791
126OBSCN0.46372784
127ATM0.45711852
128PNCK0.44026319
129RPS6KA30.43799137
130KSR20.43170481
131CSNK1D0.42306312
132PBK0.42146569
133SYK0.41624367
134TYK20.41394042
135MELK0.40394292
136MAP3K30.40234899
137CDK120.40100854
138MAP3K50.39884050
139IRAK40.39699743
140MAPKAPK20.39519105
141ICK0.39427862
142TAF10.38911607
143PRKACB0.36910533
144SGK10.36236091
145CDK20.35954258
146CDK10.35605608

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.94090996
2Vitamin B6 metabolism_Homo sapiens_hsa007504.08267371
3Mismatch repair_Homo sapiens_hsa034302.73214555
4Nitrogen metabolism_Homo sapiens_hsa009102.71448563
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.69084594
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.60463928
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55245249
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37895611
9Fatty acid degradation_Homo sapiens_hsa000712.34743613
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25043584
11Chronic myeloid leukemia_Homo sapiens_hsa052202.16047687
12Tryptophan metabolism_Homo sapiens_hsa003802.09302893
13Selenocompound metabolism_Homo sapiens_hsa004502.00452089
14Non-homologous end-joining_Homo sapiens_hsa034502.00115079
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99080354
16Propanoate metabolism_Homo sapiens_hsa006401.98558190
17Nucleotide excision repair_Homo sapiens_hsa034201.96992378
18Pancreatic cancer_Homo sapiens_hsa052121.94491285
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90894237
20Butanoate metabolism_Homo sapiens_hsa006501.89593895
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88925881
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85958082
23Fatty acid metabolism_Homo sapiens_hsa012121.82565776
24Systemic lupus erythematosus_Homo sapiens_hsa053221.82342017
25Homologous recombination_Homo sapiens_hsa034401.79883452
26Acute myeloid leukemia_Homo sapiens_hsa052211.79183129
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73054970
28Sulfur metabolism_Homo sapiens_hsa009201.72869839
29Fatty acid elongation_Homo sapiens_hsa000621.69605060
30Base excision repair_Homo sapiens_hsa034101.66444829
31Arginine biosynthesis_Homo sapiens_hsa002201.66384783
32Malaria_Homo sapiens_hsa051441.62074914
33Pyruvate metabolism_Homo sapiens_hsa006201.61193505
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56563699
35RNA transport_Homo sapiens_hsa030131.53490514
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53076749
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50936950
38Fanconi anemia pathway_Homo sapiens_hsa034601.48726776
39Steroid biosynthesis_Homo sapiens_hsa001001.47410679
40Carbon metabolism_Homo sapiens_hsa012001.46733145
41Peroxisome_Homo sapiens_hsa041461.45949037
42* ABC transporters_Homo sapiens_hsa020101.42251538
43B cell receptor signaling pathway_Homo sapiens_hsa046621.40240980
44Spliceosome_Homo sapiens_hsa030401.39916121
45mRNA surveillance pathway_Homo sapiens_hsa030151.38819280
46Bile secretion_Homo sapiens_hsa049761.35485285
47PPAR signaling pathway_Homo sapiens_hsa033201.34956030
48Histidine metabolism_Homo sapiens_hsa003401.34023560
49Fat digestion and absorption_Homo sapiens_hsa049751.32716827
50Sulfur relay system_Homo sapiens_hsa041221.32441084
51Folate biosynthesis_Homo sapiens_hsa007901.32126887
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32040684
53Renal cell carcinoma_Homo sapiens_hsa052111.30637965
54Biosynthesis of amino acids_Homo sapiens_hsa012301.28106774
55Complement and coagulation cascades_Homo sapiens_hsa046101.24808890
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.20922941
57beta-Alanine metabolism_Homo sapiens_hsa004101.20821338
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20665165
59Thyroid cancer_Homo sapiens_hsa052161.19644631
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19542873
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.13969152
62Hepatitis B_Homo sapiens_hsa051611.13769139
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13675413
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.08450009
65Caffeine metabolism_Homo sapiens_hsa002321.06903372
66Other glycan degradation_Homo sapiens_hsa005111.06575717
67Small cell lung cancer_Homo sapiens_hsa052221.05829684
68Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05501739
69Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04761905
70mTOR signaling pathway_Homo sapiens_hsa041501.02419140
71Lysine degradation_Homo sapiens_hsa003101.02371304
72Prostate cancer_Homo sapiens_hsa052151.00635392
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99494367
74Starch and sucrose metabolism_Homo sapiens_hsa005000.99204486
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98281127
76Phenylalanine metabolism_Homo sapiens_hsa003600.96107935
77Glioma_Homo sapiens_hsa052140.95628462
78One carbon pool by folate_Homo sapiens_hsa006700.95363336
79Alcoholism_Homo sapiens_hsa050340.89861118
80Arginine and proline metabolism_Homo sapiens_hsa003300.88734777
81MicroRNAs in cancer_Homo sapiens_hsa052060.87920312
82Pentose phosphate pathway_Homo sapiens_hsa000300.87603872
83Glutathione metabolism_Homo sapiens_hsa004800.86963958
84Chemical carcinogenesis_Homo sapiens_hsa052040.86321659
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86148624
86Inositol phosphate metabolism_Homo sapiens_hsa005620.85775087
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85142655
88HIF-1 signaling pathway_Homo sapiens_hsa040660.85059197
89FoxO signaling pathway_Homo sapiens_hsa040680.85028610
90Endometrial cancer_Homo sapiens_hsa052130.84355308
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81249654
92Tyrosine metabolism_Homo sapiens_hsa003500.81198793
93Herpes simplex infection_Homo sapiens_hsa051680.79665687
94p53 signaling pathway_Homo sapiens_hsa041150.78157222
95Oocyte meiosis_Homo sapiens_hsa041140.77397207
96Apoptosis_Homo sapiens_hsa042100.77283112
97N-Glycan biosynthesis_Homo sapiens_hsa005100.75712678
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75517120
99Measles_Homo sapiens_hsa051620.74485561
100Pyrimidine metabolism_Homo sapiens_hsa002400.73781653
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70497298
102VEGF signaling pathway_Homo sapiens_hsa043700.69283917
103HTLV-I infection_Homo sapiens_hsa051660.68853846
104Prolactin signaling pathway_Homo sapiens_hsa049170.67685669
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67068988
106Hematopoietic cell lineage_Homo sapiens_hsa046400.66460786
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66209791
108Metabolic pathways_Homo sapiens_hsa011000.65661873
109Influenza A_Homo sapiens_hsa051640.64266619
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.64154889
111Fructose and mannose metabolism_Homo sapiens_hsa000510.63584314
112Epstein-Barr virus infection_Homo sapiens_hsa051690.63324487
113Colorectal cancer_Homo sapiens_hsa052100.62850705
114Glycerolipid metabolism_Homo sapiens_hsa005610.62823302
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62806002
116AMPK signaling pathway_Homo sapiens_hsa041520.61990470
117Vitamin digestion and absorption_Homo sapiens_hsa049770.61389871
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60621093
119Parkinsons disease_Homo sapiens_hsa050120.60344487
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.59807623
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59095798
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57506491
123Bladder cancer_Homo sapiens_hsa052190.57459802
124ErbB signaling pathway_Homo sapiens_hsa040120.57376753
125Choline metabolism in cancer_Homo sapiens_hsa052310.57029105
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56125587
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55606430
128Melanoma_Homo sapiens_hsa052180.55273047
129Platelet activation_Homo sapiens_hsa046110.55154333
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.53811894
131Hepatitis C_Homo sapiens_hsa051600.52963339
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.52879517
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.52400373
134Insulin resistance_Homo sapiens_hsa049310.51864164
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.51060004
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50258135
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50248502
138African trypanosomiasis_Homo sapiens_hsa051430.48786578
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48532420
140Retinol metabolism_Homo sapiens_hsa008300.47972755
141T cell receptor signaling pathway_Homo sapiens_hsa046600.47936791
142Leishmaniasis_Homo sapiens_hsa051400.47259655
143Galactose metabolism_Homo sapiens_hsa000520.46828243
144DNA replication_Homo sapiens_hsa030300.46771097
145Basal transcription factors_Homo sapiens_hsa030220.46306148
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42307756
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42188734
148Protein export_Homo sapiens_hsa030600.41770571
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41618487
150Osteoclast differentiation_Homo sapiens_hsa043800.38467843
151Linoleic acid metabolism_Homo sapiens_hsa005910.38098649
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32105048
153Prion diseases_Homo sapiens_hsa050200.31684587
154Regulation of autophagy_Homo sapiens_hsa041400.30863645
155Insulin signaling pathway_Homo sapiens_hsa049100.30004314
156Glucagon signaling pathway_Homo sapiens_hsa049220.27838948
157Oxidative phosphorylation_Homo sapiens_hsa001900.24334449
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23987564
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20225108
160Fatty acid biosynthesis_Homo sapiens_hsa000610.20205927
161Type II diabetes mellitus_Homo sapiens_hsa049300.18436956
162Non-small cell lung cancer_Homo sapiens_hsa052230.17145399
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16003697
164Cell cycle_Homo sapiens_hsa041100.13758960
165Viral carcinogenesis_Homo sapiens_hsa052030.13114023
166Alzheimers disease_Homo sapiens_hsa050100.10595004

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