ABCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.95327091
2alpha-linolenic acid metabolic process (GO:0036109)4.88595574
3complement activation, alternative pathway (GO:0006957)4.87551450
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.51855856
5L-phenylalanine catabolic process (GO:0006559)4.51855856
6regulation of protein activation cascade (GO:2000257)4.48516587
7regulation of complement activation (GO:0030449)4.32213321
8plasma lipoprotein particle clearance (GO:0034381)4.30860207
9positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.26511428
10low-density lipoprotein particle clearance (GO:0034383)4.25695666
11protein carboxylation (GO:0018214)4.21920220
12peptidyl-glutamic acid carboxylation (GO:0017187)4.21920220
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.18110766
14L-phenylalanine metabolic process (GO:0006558)4.18110766
15urea cycle (GO:0000050)4.08347488
16urea metabolic process (GO:0019627)4.08347488
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01892194
18aromatic amino acid family catabolic process (GO:0009074)3.96736209
19detection of molecule of bacterial origin (GO:0032490)3.92057859
20high-density lipoprotein particle remodeling (GO:0034375)3.87957494
21glucocorticoid biosynthetic process (GO:0006704)3.84802486
22positive regulation of fatty acid beta-oxidation (GO:0032000)3.84615734
23bile acid biosynthetic process (GO:0006699)3.81281051
24negative regulation of fibrinolysis (GO:0051918)3.80927089
25regulation of triglyceride catabolic process (GO:0010896)3.79309360
26sulfur amino acid catabolic process (GO:0000098)3.75231472
27* reverse cholesterol transport (GO:0043691)3.68156099
28nitrogen cycle metabolic process (GO:0071941)3.67291602
29plasma lipoprotein particle remodeling (GO:0034369)3.65687539
30protein-lipid complex remodeling (GO:0034368)3.65687539
31macromolecular complex remodeling (GO:0034367)3.65687539
32regulation of fibrinolysis (GO:0051917)3.63705353
33regulation of cytokine secretion involved in immune response (GO:0002739)3.57291544
34positive regulation of lipid catabolic process (GO:0050996)3.51572798
35triglyceride homeostasis (GO:0070328)3.49932799
36acylglycerol homeostasis (GO:0055090)3.49932799
37regulation of cholesterol esterification (GO:0010872)3.49269391
38indole-containing compound catabolic process (GO:0042436)3.48399241
39indolalkylamine catabolic process (GO:0046218)3.48399241
40tryptophan catabolic process (GO:0006569)3.48399241
41tryptophan metabolic process (GO:0006568)3.48072342
42oligosaccharide catabolic process (GO:0009313)3.47246909
43kynurenine metabolic process (GO:0070189)3.41435705
44retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39903912
45bile acid metabolic process (GO:0008206)3.39826518
46glyoxylate metabolic process (GO:0046487)3.38422789
47low-density lipoprotein particle remodeling (GO:0034374)3.37939555
48cysteine metabolic process (GO:0006534)3.35983783
49cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.35821074
50* phospholipid homeostasis (GO:0055091)3.32741900
51complement activation (GO:0006956)3.32023486
52* phospholipid efflux (GO:0033700)3.28015458
53homocysteine metabolic process (GO:0050667)3.27829855
54* regulation of cholesterol storage (GO:0010885)3.24994453
55regulation of heterotypic cell-cell adhesion (GO:0034114)3.23081844
56complement activation, classical pathway (GO:0006958)3.20887521
57* cholesterol efflux (GO:0033344)3.20173981
58positive regulation of fatty acid oxidation (GO:0046321)3.20091278
59tyrosine metabolic process (GO:0006570)3.18825154
60regulation of mononuclear cell migration (GO:0071675)3.18559481
61positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17609887
62amino-acid betaine metabolic process (GO:0006577)3.17560844
63regulation of fatty acid beta-oxidation (GO:0031998)3.13147100
64keratan sulfate catabolic process (GO:0042340)3.12480587
65regulation of membrane protein ectodomain proteolysis (GO:0051043)3.10787301
66fibrinolysis (GO:0042730)3.10186564
67protein activation cascade (GO:0072376)3.08532809
68* plasma lipoprotein particle assembly (GO:0034377)3.07094920
69regulation of sequestering of triglyceride (GO:0010889)3.07053600
70* lipoprotein metabolic process (GO:0042157)3.06423966
71negative regulation of protein activation cascade (GO:2000258)3.04367681
72apoptotic cell clearance (GO:0043277)2.99488657
73fatty acid transmembrane transport (GO:1902001)2.98217755
74regulation of macrophage chemotaxis (GO:0010758)2.97892793
75lysine catabolic process (GO:0006554)2.97340206
76lysine metabolic process (GO:0006553)2.97340206
77positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97226813
78dicarboxylic acid biosynthetic process (GO:0043650)2.96231382
79bile acid and bile salt transport (GO:0015721)2.95758962
80* plasma lipoprotein particle organization (GO:0071827)2.95489412
81cell adhesion mediated by integrin (GO:0033627)2.95320106
82regulation of fever generation (GO:0031620)2.94578327
83negative regulation of sterol transport (GO:0032372)2.94111225
84negative regulation of cholesterol transport (GO:0032375)2.94111225
85glucocorticoid metabolic process (GO:0008211)2.94044382
86regulation of cholesterol homeostasis (GO:2000188)2.93759158
87valine metabolic process (GO:0006573)2.90842074
88serine family amino acid catabolic process (GO:0009071)2.90364881
89positive regulation of cellular amide metabolic process (GO:0034250)2.89381546
90branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89021130
91positive regulation vascular endothelial growth factor production (GO:0010575)2.88001141
92cellular modified amino acid catabolic process (GO:0042219)2.87178232
93* protein-lipid complex assembly (GO:0065005)2.87046703
94negative regulation of lipase activity (GO:0060192)2.85703469
95regulation of cholesterol biosynthetic process (GO:0045540)2.85187920
96* protein-lipid complex subunit organization (GO:0071825)2.84902456
97response to follicle-stimulating hormone (GO:0032354)2.84271531
98fatty acid beta-oxidation (GO:0006635)2.83666338
99positive regulation by symbiont of host defense response (GO:0052509)2.83393710
100modulation by symbiont of host defense response (GO:0052031)2.83393710
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83393710
102modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83393710
103positive regulation by organism of defense response of other organism involved in symbiotic interact2.83393710
104modulation by symbiont of host immune response (GO:0052553)2.83393710
105cellular response to thyroid hormone stimulus (GO:0097067)2.83348953
106* negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.83242218
107positive regulation of blood coagulation (GO:0030194)2.82451573
108positive regulation of hemostasis (GO:1900048)2.82451573
109regulation of vascular endothelial growth factor production (GO:0010574)2.82142760
110lipid oxidation (GO:0034440)2.80980623
111* positive regulation of cholesterol efflux (GO:0010875)2.80839513
112fatty acid oxidation (GO:0019395)2.80689792
113positive regulation of steroid metabolic process (GO:0045940)2.80011925
114alpha-amino acid catabolic process (GO:1901606)2.79096798
115* cholesterol homeostasis (GO:0042632)2.78186706
116cellular response to ethanol (GO:0071361)2.77386258
117* positive regulation of cholesterol transport (GO:0032376)2.76476617
118* positive regulation of sterol transport (GO:0032373)2.76476617
119regulation of apoptotic cell clearance (GO:2000425)2.76425016
120regulation of heat generation (GO:0031650)2.76174340
121* sterol homeostasis (GO:0055092)2.76134148
122very-low-density lipoprotein particle assembly (GO:0034379)2.75572246
123aromatic amino acid family metabolic process (GO:0009072)2.74930028
124regulation of lipid catabolic process (GO:0050994)2.74892403
125acute-phase response (GO:0006953)2.74545846
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74259422
127fatty acid homeostasis (GO:0055089)2.74017280
128linoleic acid metabolic process (GO:0043651)2.73514958
129positive regulation of triglyceride metabolic process (GO:0090208)2.72984133
130negative regulation of complement activation (GO:0045916)2.61675281
131positive regulation of heat generation (GO:0031652)2.60635953
132regulation of chemokine-mediated signaling pathway (GO:0070099)2.57360891
133* sterol transport (GO:0015918)2.56092488
134* cholesterol transport (GO:0030301)2.56092488
135serine transport (GO:0032329)2.54260717
136C21-steroid hormone biosynthetic process (GO:0006700)2.53641768
137glycosphingolipid catabolic process (GO:0046479)2.53546507
138L-serine transport (GO:0015825)2.50107333
139amino sugar catabolic process (GO:0046348)2.40467506
140positive regulation of coagulation (GO:0050820)2.40351041
141interleukin-6-mediated signaling pathway (GO:0070102)2.38977953
142negative regulation of platelet activation (GO:0010544)2.37548311
143negative regulation of cytokine production involved in immune response (GO:0002719)2.32805375
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32797691
145regulation of interleukin-8 biosynthetic process (GO:0045414)2.27174400
146response to methylmercury (GO:0051597)2.25041048
147progesterone metabolic process (GO:0042448)2.24617855
148negative regulation of hemostasis (GO:1900047)2.23735442
149negative regulation of blood coagulation (GO:0030195)2.23735442
150negative regulation of production of molecular mediator of immune response (GO:0002701)2.21750025
151negative regulation of coagulation (GO:0050819)2.21599110
152* response to lipoprotein particle (GO:0055094)2.21323954
153glycolipid catabolic process (GO:0019377)2.21298902
154C21-steroid hormone metabolic process (GO:0008207)2.19831883
155positive regulation of chemokine secretion (GO:0090197)2.19171946
156positive regulation of extracellular matrix organization (GO:1903055)2.17951723
157positive regulation of lipid storage (GO:0010884)2.16915599
158transcytosis (GO:0045056)2.16903363
159* negative regulation of lipid storage (GO:0010888)2.15093294
160ovulation from ovarian follicle (GO:0001542)2.14740572
161ceramide catabolic process (GO:0046514)2.13028440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.89227517
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.09435123
3* LXR_22158963_ChIP-Seq_LIVER_Mouse4.49757064
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.31820627
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25387908
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.62106829
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46629135
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.99324718
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44985511
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.28309177
11* CLOCK_20551151_ChIP-Seq_293T_Human2.25608173
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20922613
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20184826
14GBX2_23144817_ChIP-Seq_PC3_Human2.16963808
15GATA1_22025678_ChIP-Seq_K562_Human2.10384847
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96068716
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94364193
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83248353
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77877842
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77504359
21* IRF8_27001747_Chip-Seq_BMDM_Mouse1.70829714
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70207246
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.68903280
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62188313
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61699345
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59900565
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59034025
28* P300_19829295_ChIP-Seq_ESCs_Human1.56630942
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55623839
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.53717954
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.51010878
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50669171
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48191639
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.47664684
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.45900183
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45805650
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45665809
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44208228
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.43915258
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43186120
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40420991
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.39261153
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38383468
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36370853
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35282666
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.34974925
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34867867
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33316078
49* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32956109
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32469535
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31290538
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.31205214
53TP53_18474530_ChIP-ChIP_U2OS_Human1.30387897
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29717528
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29466508
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.29385554
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28069133
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.27950130
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26543445
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26543445
61SMAD4_21799915_ChIP-Seq_A2780_Human1.25594520
62* ESR1_21235772_ChIP-Seq_MCF-7_Human1.24355319
63* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24040682
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.23814789
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23465747
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22063593
67* BRD4_25478319_ChIP-Seq_HGPS_Human1.21978765
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20877417
69* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19963560
70* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19847564
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19198729
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.18285508
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17898262
74SMAD4_21741376_ChIP-Seq_HESCs_Human1.14745648
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14451403
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14190427
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.13794605
78CDX2_22108803_ChIP-Seq_LS180_Human1.13598263
79AR_25329375_ChIP-Seq_VCAP_Human1.11668662
80IGF1R_20145208_ChIP-Seq_DFB_Human1.11359755
81TAF15_26573619_Chip-Seq_HEK293_Human1.10417429
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.10168014
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08505228
84* VDR_24787735_ChIP-Seq_THP-1_Human1.07961904
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07391704
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06614689
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06289005
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.06253462
89CJUN_26792858_Chip-Seq_BT549_Human1.05727188
90GATA1_19941826_ChIP-Seq_K562_Human1.04682862
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04284627
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03723701
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03715220
94P53_22387025_ChIP-Seq_ESCs_Mouse1.03272666
95* STAT3_23295773_ChIP-Seq_U87_Human1.01253071
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99857588
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.99493460
98* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99233994
99* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98966397
100* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97859179
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97753157
102* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97413662
103* P300_18555785_Chip-Seq_ESCs_Mouse0.97211100
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.96755169
105* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95187390
106* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95174020
107RUNX_20019798_ChIP-Seq_JUKART_Human0.93204357
108BCAT_22108803_ChIP-Seq_LS180_Human0.93158827
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92483995
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.91563432
111* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91287838
112GATA2_19941826_ChIP-Seq_K562_Human0.90533485
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90527197
114* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89985463
115* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89009099
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88048318
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87794565
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86410153
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85529335
120SOX2_20726797_ChIP-Seq_SW620_Human0.84288200
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84211131
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84182738
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84080554
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83480786
125AHR_22903824_ChIP-Seq_MCF-7_Human0.81975234
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.81255550
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81205012
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.80966671
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.80966671
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80314098
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79919043
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78511712
133RXR_22108803_ChIP-Seq_LS180_Human0.77595947
134TP63_23658742_ChIP-Seq_EP156T_Human0.75738638
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.75642646
136TP53_16413492_ChIP-PET_HCT116_Human0.74613305
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74467600
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.73073932
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72892679
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.71906185
141GATA4_25053715_ChIP-Seq_YYC3_Human0.70720083
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.70437767
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.70033518
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.69955003
145SCL_19346495_ChIP-Seq_HPC-7_Human0.69084540
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67312665
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.62903515
148SPI1_23127762_ChIP-Seq_K562_Human0.62295774
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61587313
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.60910638
151KDM2B_26808549_Chip-Seq_SUP-B15_Human0.59823341
152PU_27001747_Chip-Seq_BMDM_Mouse0.59754400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.44391476
2MP0002139_abnormal_hepatobiliary_system5.36909498
3MP0005360_urolithiasis5.02510642
4MP0005365_abnormal_bile_salt4.49012501
5MP0005085_abnormal_gallbladder_physiolo4.07108302
6MP0003252_abnormal_bile_duct3.36564808
7MP0008004_abnormal_stomach_pH3.29849675
8* MP0010329_abnormal_lipoprotein_level3.18397636
9MP0009840_abnormal_foam_cell3.13565329
10MP0008875_abnormal_xenobiotic_pharmacok2.88783523
11MP0005670_abnormal_white_adipose2.85934109
12MP0008438_abnormal_cutaneous_collagen2.42387317
13* MP0003191_abnormal_cellular_cholesterol2.34496472
14MP0003705_abnormal_hypodermis_morpholog2.24101598
15MP0003690_abnormal_glial_cell2.20654841
16MP0003195_calcinosis2.17874660
17MP0005058_abnormal_lysosome_morphology2.11184451
18MP0004130_abnormal_muscle_cell2.08569494
19* MP0000609_abnormal_liver_physiology2.07945875
20MP0005083_abnormal_biliary_tract1.98009754
21* MP0002118_abnormal_lipid_homeostasis1.97913196
22MP0003300_gastrointestinal_ulcer1.85633771
23MP0005332_abnormal_amino_acid1.84706092
24MP0005666_abnormal_adipose_tissue1.73881209
25MP0003724_increased_susceptibility_to1.70813976
26MP0003941_abnormal_skin_development1.68591861
27MP0005167_abnormal_blood-brain_barrier1.56607300
28MP0005257_abnormal_intraocular_pressure1.53904051
29MP0003950_abnormal_plasma_membrane1.51383263
30MP0003329_amyloid_beta_deposits1.51274388
31MP0010368_abnormal_lymphatic_system1.50424329
32* MP0001666_abnormal_nutrient_absorption1.49686350
33MP0001984_abnormal_olfaction1.47162767
34MP0003436_decreased_susceptibility_to1.45418273
35MP0005319_abnormal_enzyme/_coenzyme1.45198114
36MP0003303_peritoneal_inflammation1.43409824
37* MP0001915_intracranial_hemorrhage1.36697675
38MP0002138_abnormal_hepatobiliary_system1.36452412
39MP0002148_abnormal_hypersensitivity_rea1.35342531
40MP0005451_abnormal_body_composition1.33894335
41MP0003890_abnormal_embryonic-extraembry1.33453148
42MP0003075_altered_response_to1.33293344
43MP0009764_decreased_sensitivity_to1.31586435
44MP0002971_abnormal_brown_adipose1.31515681
45MP0004510_myositis1.30418881
46MP0003806_abnormal_nucleotide_metabolis1.29312424
47MP0003172_abnormal_lysosome_physiology1.29293543
48MP0003045_fibrosis1.28953968
49MP0004185_abnormal_adipocyte_glucose1.28426292
50MP0003868_abnormal_feces_composition1.24995592
51MP0009785_altered_susceptibility_to1.24242913
52MP0005584_abnormal_enzyme/coenzyme_acti1.24001102
53MP0005334_abnormal_fat_pad1.23814169
54MP0005275_abnormal_skin_tensile1.23548122
55* MP0000604_amyloidosis1.23021483
56* MP0004019_abnormal_vitamin_homeostasis1.22070876
57MP0005375_adipose_tissue_phenotype1.19439006
58MP0000920_abnormal_myelination1.17788527
59MP0002168_other_aberrant_phenotype1.17531862
60MP0000569_abnormal_digit_pigmentation1.17518105
61MP0009643_abnormal_urine_homeostasis1.15711966
62MP0009115_abnormal_fat_cell1.13969248
63MP0002332_abnormal_exercise_endurance1.13963888
64MP0001533_abnormal_skeleton_physiology1.11326039
65MP0009763_increased_sensitivity_to1.11208115
66MP0001661_extended_life_span1.10560375
67MP0003633_abnormal_nervous_system1.10272464
68MP0006082_CNS_inflammation1.10086345
69MP0001958_emphysema1.09022975
70MP0003279_aneurysm1.07359229
71* MP0008469_abnormal_protein_level1.06912609
72MP0005647_abnormal_sex_gland1.06025330
73* MP0002419_abnormal_innate_immunity1.04743090
74MP0003632_abnormal_nervous_system1.04274638
75MP0000598_abnormal_liver_morphology1.03446282
76MP0003448_altered_tumor_morphology1.03092992
77MP0003828_pulmonary_edema1.00857084
78MP0005164_abnormal_response_to1.00568257
79MP0003011_delayed_dark_adaptation0.96530155
80MP0004883_abnormal_blood_vessel0.96484800
81MP0004272_abnormal_basement_membrane0.96163523
82* MP0005464_abnormal_platelet_physiology0.96135150
83MP0002078_abnormal_glucose_homeostasis0.95343409
84MP0004484_altered_response_of0.93041756
85MP0005535_abnormal_body_temperature0.92214933
86MP0000249_abnormal_blood_vessel0.91762001
87MP0009384_cardiac_valve_regurgitation0.91084273
88MP0009780_abnormal_chondrocyte_physiolo0.90742259
89MP0002166_altered_tumor_susceptibility0.89094754
90MP0000343_altered_response_to0.88862880
91MP0000013_abnormal_adipose_tissue0.88478738
92* MP0000639_abnormal_adrenal_gland0.88043105
93MP0005166_decreased_susceptibility_to0.87755173
94MP0001756_abnormal_urination0.87606445
95MP0003453_abnormal_keratinocyte_physiol0.85253884
96MP0002928_abnormal_bile_duct0.84836356
97MP0003566_abnormal_cell_adhesion0.84735332
98MP0000767_abnormal_smooth_muscle0.84612564
99MP0001835_abnormal_antigen_presentation0.83635282
100MP0010352_gastrointestinal_tract_polyps0.82683618
101MP0010678_abnormal_skin_adnexa0.82674140
102* MP0002295_abnormal_pulmonary_circulatio0.82258127
103MP0005165_increased_susceptibility_to0.82217028
104MP0002896_abnormal_bone_mineralization0.81447177
105MP0005448_abnormal_energy_balance0.81066944
106MP0003656_abnormal_erythrocyte_physiolo0.81057218
107MP0001879_abnormal_lymphatic_vessel0.80407454
108MP0001790_abnormal_immune_system0.80032294
109MP0005387_immune_system_phenotype0.80032294
110MP0003221_abnormal_cardiomyocyte_apopto0.78632468
111MP0009697_abnormal_copulation0.77858905
112MP0000371_diluted_coat_color0.77234206
113MP0003631_nervous_system_phenotype0.77213725
114* MP0009642_abnormal_blood_homeostasis0.77146196
115MP0002998_abnormal_bone_remodeling0.76785684
116MP0001324_abnormal_eye_pigmentation0.76272959
117MP0001853_heart_inflammation0.74862028
118MP0002090_abnormal_vision0.74723727
119MP0004858_abnormal_nervous_system0.74020486
120MP0000647_abnormal_sebaceous_gland0.73943021
121MP0003186_abnormal_redox_activity0.73050656
122MP0003634_abnormal_glial_cell0.72636385
123MP0000003_abnormal_adipose_tissue0.72466810
124MP0002060_abnormal_skin_morphology0.72427644
125MP0001764_abnormal_homeostasis0.70300351
126MP0008260_abnormal_autophagy0.70269038
127MP0000516_abnormal_urinary_system0.69858001
128MP0005367_renal/urinary_system_phenotyp0.69858001
129MP0002909_abnormal_adrenal_gland0.69365712
130MP0002133_abnormal_respiratory_system0.68537177
131MP0005388_respiratory_system_phenotype0.68537177
132MP0010386_abnormal_urinary_bladder0.66663665
133MP0000383_abnormal_hair_follicle0.66341610
134MP0005248_abnormal_Harderian_gland0.65696669
135* MP0001845_abnormal_inflammatory_respons0.63503401
136MP0010234_abnormal_vibrissa_follicle0.63137395
137MP0005023_abnormal_wound_healing0.62869811
138* MP0002136_abnormal_kidney_physiology0.62848037
139MP0003183_abnormal_peptide_metabolism0.62321545
140MP0003091_abnormal_cell_migration0.60882275
141MP0005595_abnormal_vascular_smooth0.59906322
142MP0004947_skin_inflammation0.59707223
143MP0001881_abnormal_mammary_gland0.59480086

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.35818228
2Abnormality of glycolipid metabolism (HP:0010969)5.59905656
3Abnormality of liposaccharide metabolism (HP:0010968)5.59905656
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.59905656
5Deep venous thrombosis (HP:0002625)5.47784958
6Xanthomatosis (HP:0000991)5.21524725
7Systemic lupus erythematosus (HP:0002725)5.04433214
8Intrahepatic cholestasis (HP:0001406)4.87742004
9Abnormality of complement system (HP:0005339)4.75646809
10Prolonged partial thromboplastin time (HP:0003645)4.40953487
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.27011715
12Joint hemorrhage (HP:0005261)4.19421545
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.17944544
14Hyperlipoproteinemia (HP:0010980)4.11608877
15Abnormality of the common coagulation pathway (HP:0010990)4.02280115
16Epidermoid cyst (HP:0200040)3.97671423
17Glomerulonephritis (HP:0000099)3.92430902
18Hypoglycemic coma (HP:0001325)3.80994904
19Disinhibition (HP:0000734)3.64632953
20Hypobetalipoproteinemia (HP:0003563)3.48147437
21* Myocardial infarction (HP:0001658)3.39002063
22Recurrent gram-negative bacterial infections (HP:0005420)3.33031986
23* Hypoalphalipoproteinemia (HP:0003233)3.28586574
24Hypercholesterolemia (HP:0003124)3.25687053
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21755004
26Ketosis (HP:0001946)3.21119047
27Nuclear cataract (HP:0100018)3.18794996
28Loss of speech (HP:0002371)3.15107530
29* Hypolipoproteinemia (HP:0010981)3.13889954
30Skin nodule (HP:0200036)3.10528988
31Abnormality of macrophages (HP:0004311)3.10223434
32* Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06974140
33Hyperammonemia (HP:0001987)3.05587023
34Abnormality of the intrinsic pathway (HP:0010989)2.99417484
35Hyperglycinuria (HP:0003108)2.93415445
36Nephritis (HP:0000123)2.91213139
37Hypoglycemic seizures (HP:0002173)2.89663794
38Amyloidosis (HP:0011034)2.82148925
39Ketoacidosis (HP:0001993)2.76678609
40Retrobulbar optic neuritis (HP:0100654)2.73375621
41Optic neuritis (HP:0100653)2.73375621
42Mitral stenosis (HP:0001718)2.73192045
43Fat malabsorption (HP:0002630)2.69920805
44Cerebral aneurysm (HP:0004944)2.66697500
45Abnormality of the axillary hair (HP:0100134)2.66402602
46Abnormality of secondary sexual hair (HP:0009888)2.66402602
47Abnormality of glycine metabolism (HP:0010895)2.64683616
48Abnormality of serine family amino acid metabolism (HP:0010894)2.64683616
49Orchitis (HP:0100796)2.64045083
50Esophageal varix (HP:0002040)2.64037873
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.60537392
52Mutism (HP:0002300)2.59325073
53Conjugated hyperbilirubinemia (HP:0002908)2.55107434
54Dysostosis multiplex (HP:0000943)2.53219948
55Hyperglycinemia (HP:0002154)2.51071881
56Hemorrhage of the eye (HP:0011885)2.45025093
57Mucopolysacchariduria (HP:0008155)2.44868306
58Urinary glycosaminoglycan excretion (HP:0003541)2.44868306
59Hydroxyprolinuria (HP:0003080)2.42369832
60Abnormality of proline metabolism (HP:0010907)2.42369832
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38420758
62Hyperinsulinemic hypoglycemia (HP:0000825)2.38186554
63Abnormality of the periventricular white matter (HP:0002518)2.37828699
64Cerebral inclusion bodies (HP:0100314)2.37675077
65Hepatocellular carcinoma (HP:0001402)2.37565168
66Hematochezia (HP:0002573)2.36286664
67Retinal atrophy (HP:0001105)2.35204932
68Increased cerebral lipofuscin (HP:0011813)2.32755141
69Axonal loss (HP:0003447)2.31629997
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29985346
71Abnormality of polysaccharide metabolism (HP:0011012)2.29985346
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29985346
73Inappropriate behavior (HP:0000719)2.28696664
74Gingival bleeding (HP:0000225)2.28262651
75Papillary thyroid carcinoma (HP:0002895)2.22895474
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21034625
77Abnormality of methionine metabolism (HP:0010901)2.19719719
78Abnormality of fatty-acid metabolism (HP:0004359)2.17136091
79Hypertriglyceridemia (HP:0002155)2.16975266
80Upper motor neuron abnormality (HP:0002127)2.16354688
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15459210
82Metaphyseal irregularity (HP:0003025)2.15076967
83Pulmonary artery stenosis (HP:0004415)2.12596578
84Hyperglycemia (HP:0003074)2.12016780
85Aortic aneurysm (HP:0004942)2.10427452
86Spontaneous abortion (HP:0005268)2.10361764
87Flared iliac wings (HP:0002869)2.09853228
88Sensorimotor neuropathy (HP:0007141)2.09405488
89Increased CSF protein (HP:0002922)2.08362596
90Vacuolated lymphocytes (HP:0001922)2.07569457
91Aortic dissection (HP:0002647)2.05991181
92Tetraparesis (HP:0002273)2.01481381
93Abnormality of purine metabolism (HP:0004352)1.99594671
94Turricephaly (HP:0000262)1.96100766
95Spondylolisthesis (HP:0003302)1.95774074
96Peritonitis (HP:0002586)1.93338269
97Cardiovascular calcification (HP:0011915)1.92512532
98Spastic diplegia (HP:0001264)1.91907932
99Vascular calcification (HP:0004934)1.91619310
100Autoimmune thrombocytopenia (HP:0001973)1.91117516
101Ovoid vertebral bodies (HP:0003300)1.90884098
102Spontaneous hematomas (HP:0007420)1.88630524
103Abnormality of nucleobase metabolism (HP:0010932)1.88482729
104Keratoconjunctivitis sicca (HP:0001097)1.87473730
105Menorrhagia (HP:0000132)1.87357914
106Striae distensae (HP:0001065)1.87287076
107Arterial tortuosity (HP:0005116)1.86621573
108Increased neuronal autofluorescent lipopigment (HP:0002074)1.85134842
109Symptomatic seizures (HP:0011145)1.84645153
110Mitral valve prolapse (HP:0001634)1.84274313
111Cervical subluxation (HP:0003308)1.84169712
112Pigmentary retinal degeneration (HP:0001146)1.83551132
113Mesangial abnormality (HP:0001966)1.83228654
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.82840425
115Osteolytic defects of the hand bones (HP:0009699)1.82840425
116Aneurysm (HP:0002617)1.80519697
117Pancreatitis (HP:0001733)1.80382926
118Thick nail (HP:0001805)1.79812612
119Portal hypertension (HP:0001409)1.79317619
120Vascular tortuosity (HP:0004948)1.79032716
121Neurofibrillary tangles (HP:0002185)1.78357780
122Recurrent bacterial skin infections (HP:0005406)1.77742036
123Intestinal atresia (HP:0011100)1.77625737
124Eczematoid dermatitis (HP:0000976)1.76615705
125Stroke (HP:0001297)1.76444498
126Steatorrhea (HP:0002570)1.76313543
127Hyperbilirubinemia (HP:0002904)1.76043925
128Beaking of vertebral bodies (HP:0004568)1.74639828
129Thrombophlebitis (HP:0004418)1.73887003
130Colitis (HP:0002583)1.73603679
131Late onset (HP:0003584)1.72332006
132Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71380394
133Conjunctival telangiectasia (HP:0000524)1.69902269
134Keratoconjunctivitis (HP:0001096)1.68960802
135Pathologic fracture (HP:0002756)1.64107816
136Myositis (HP:0100614)1.63363077
137Absent frontal sinuses (HP:0002688)1.62473338
138Agnosia (HP:0010524)1.61545041
139Recurrent abscess formation (HP:0002722)1.60947135
140Asymmetric septal hypertrophy (HP:0001670)1.59111666
141Pulmonic stenosis (HP:0001642)1.59051464
142Polyneuropathy (HP:0001271)1.58620492
143Tubulointerstitial fibrosis (HP:0005576)1.52237207
144Prolonged neonatal jaundice (HP:0006579)1.51467703
145Gonadal dysgenesis (HP:0000133)1.51117454
146Adactyly (HP:0009776)1.51071710
147Albinism (HP:0001022)1.49550229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.59202829
2TGFBR23.51816685
3SIK13.50498666
4ERN13.35639912
5INSRR3.29459012
6CAMK1D3.28314503
7AKT33.14787688
8DDR22.93021410
9TRIB32.78699221
10CAMK1G2.56532366
11FGFR42.45948911
12TRIM282.27718150
13RIPK12.14459876
14BCKDK2.06499377
15TAOK32.05466229
16TYK21.96187443
17PTK61.83005242
18ADRBK21.81234455
19TNIK1.79555309
20JAK11.78086252
21MAP4K21.77043698
22FRK1.68877420
23PBK1.68503633
24LATS11.68110966
25FGFR31.66232610
26GRK11.62056336
27MAP3K101.51298209
28NEK91.48596967
29ERBB31.47964447
30IRAK31.47382939
31EPHB11.46457252
32PKN21.46295870
33MAPK151.45409662
34FGR1.41790113
35NLK1.41142814
36CASK1.39750030
37EPHA31.37583522
38WNK31.37056264
39BMPR1B1.35492368
40PDGFRA1.34971706
41BCR1.33440103
42JAK21.32664829
43SIK31.28950937
44TBK11.23768077
45MAP3K141.23425457
46FGFR21.20860102
47TIE11.19876594
48MST1R1.19862532
49PRKAA21.19044774
50CSF1R1.08120334
51MAP3K41.06901516
52ERBB41.04041231
53PIK3CG1.01036816
54CSK1.00690083
55CDK60.98338023
56TTN0.95154332
57KDR0.94048483
58SGK30.93382317
59BLK0.93259351
60STK38L0.93072562
61EIF2AK30.90669991
62CDC42BPA0.89441447
63LMTK20.88855118
64PLK20.85556435
65IRAK20.85365999
66MAPK120.84564416
67GSK3A0.84506572
68MAP3K20.82091227
69IRAK40.82071254
70RET0.80819675
71FLT30.79820253
72KSR10.77598201
73MAPK110.77297144
74PRKCH0.77143584
75IKBKE0.76949933
76ERBB20.76551017
77IGF1R0.76550437
78JAK30.75537819
79ABL20.74238736
80MAP3K50.73875803
81PDGFRB0.72481566
82MET0.72375082
83SCYL20.71502618
84SGK20.70335236
85TGFBR10.69462333
86OBSCN0.68928167
87BMPR20.67461907
88PTK20.67139273
89DAPK20.66967448
90MAP3K30.65459925
91GRK70.64966264
92MAPK70.63699868
93MTOR0.63613330
94PRKCE0.62453835
95CDK90.62341167
96EGFR0.62323864
97PINK10.62276576
98FER0.62083640
99LATS20.61281707
100CHUK0.61273640
101MAP3K70.60401540
102FGFR10.60255277
103MELK0.59885178
104PDPK10.59739728
105PRKAA10.58560684
106PKN10.58413319
107KIT0.58189531
108TYRO30.55721110
109BMX0.55661161
110DYRK30.54647732
111CSNK1A1L0.54620814
112MAP3K130.54072997
113MAP3K60.53788205
114IRAK10.53763334
115CAMKK20.53726607
116PRKD10.53527064
117HCK0.52928219
118ITK0.52557488
119PDK20.51806824
120MAP2K30.51384466
121CSNK1G10.50909395
122MAP2K40.50853279
123STK30.50826981
124NUAK10.50329480
125YES10.49908870
126PDK10.48873977
127MOS0.48477466
128PAK20.47986241
129INSR0.47823694
130NTRK10.46754965
131MAP3K10.46279838
132STK240.46124151
133ABL10.44914555
134MAPK130.43886786
135IKBKB0.43882113
136* PRKACG0.43827765
137ROCK10.43276984
138CSNK1G20.42800073
139PAK30.42499358
140RIPK40.41881539
141MAP2K10.41013941
142DYRK1B0.40706961
143CDK120.39332982
144STK100.38934369
145MATK0.37522739
146SGK2230.36605329
147SGK4940.36605329
148PHKG10.36299255
149PHKG20.36299255

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.45813451
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.63322427
3Complement and coagulation cascades_Homo sapiens_hsa046103.24139612
4Staphylococcus aureus infection_Homo sapiens_hsa051503.17145234
5Arginine biosynthesis_Homo sapiens_hsa002202.61483397
6Fatty acid degradation_Homo sapiens_hsa000712.47575861
7PPAR signaling pathway_Homo sapiens_hsa033202.44240790
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35976965
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12466677
10Tryptophan metabolism_Homo sapiens_hsa003802.12379996
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11615448
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08874338
13Fatty acid metabolism_Homo sapiens_hsa012122.06110526
14Caffeine metabolism_Homo sapiens_hsa002321.87041647
15Propanoate metabolism_Homo sapiens_hsa006401.76576448
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69981824
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66397691
18Rheumatoid arthritis_Homo sapiens_hsa053231.63312517
19Peroxisome_Homo sapiens_hsa041461.62652100
20Fatty acid biosynthesis_Homo sapiens_hsa000611.58983534
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58304919
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53326112
23Butanoate metabolism_Homo sapiens_hsa006501.50433339
24Bile secretion_Homo sapiens_hsa049761.44758243
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44295354
26beta-Alanine metabolism_Homo sapiens_hsa004101.41231894
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39996585
28Histidine metabolism_Homo sapiens_hsa003401.36817033
29* ABC transporters_Homo sapiens_hsa020101.32118406
30Sphingolipid metabolism_Homo sapiens_hsa006001.26930461
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24485766
32Chemical carcinogenesis_Homo sapiens_hsa052041.23017288
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.22267346
34Starch and sucrose metabolism_Homo sapiens_hsa005001.18542832
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.16976512
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15748084
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10881519
38TNF signaling pathway_Homo sapiens_hsa046681.07621307
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07079681
40Mineral absorption_Homo sapiens_hsa049781.05785997
41Retinol metabolism_Homo sapiens_hsa008301.05620928
42Selenocompound metabolism_Homo sapiens_hsa004501.04310020
43Phenylalanine metabolism_Homo sapiens_hsa003601.03973108
44Glycerolipid metabolism_Homo sapiens_hsa005611.03878534
45Lysine degradation_Homo sapiens_hsa003101.02971832
46* Fat digestion and absorption_Homo sapiens_hsa049751.02353954
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.01281075
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99530792
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98962673
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.97647472
51Lysosome_Homo sapiens_hsa041420.94923551
52Tyrosine metabolism_Homo sapiens_hsa003500.92476759
53Insulin resistance_Homo sapiens_hsa049310.91649816
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91197827
55Prion diseases_Homo sapiens_hsa050200.89429441
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88756283
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87213148
58Salmonella infection_Homo sapiens_hsa051320.87205411
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85593144
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.83382863
61Sulfur metabolism_Homo sapiens_hsa009200.80529958
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78754072
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.78065325
64Pyruvate metabolism_Homo sapiens_hsa006200.76599008
65Vitamin digestion and absorption_Homo sapiens_hsa049770.74215921
66Fatty acid elongation_Homo sapiens_hsa000620.70547548
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.68720983
68TGF-beta signaling pathway_Homo sapiens_hsa043500.67864570
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64446787
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62910628
71HIF-1 signaling pathway_Homo sapiens_hsa040660.62503038
72Malaria_Homo sapiens_hsa051440.59705293
73Other glycan degradation_Homo sapiens_hsa005110.57446887
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57342978
75Carbon metabolism_Homo sapiens_hsa012000.56103549
76Osteoclast differentiation_Homo sapiens_hsa043800.54061914
77Steroid biosynthesis_Homo sapiens_hsa001000.51920193
78Type II diabetes mellitus_Homo sapiens_hsa049300.51893610
79Pertussis_Homo sapiens_hsa051330.51820668
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49863071
81Amoebiasis_Homo sapiens_hsa051460.48909678
82AMPK signaling pathway_Homo sapiens_hsa041520.48871773
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45049651
84Collecting duct acid secretion_Homo sapiens_hsa049660.44706919
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43638587
86Circadian rhythm_Homo sapiens_hsa047100.43168265
87Ether lipid metabolism_Homo sapiens_hsa005650.42021294
88Leishmaniasis_Homo sapiens_hsa051400.42020851
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40309881
90Dorso-ventral axis formation_Homo sapiens_hsa043200.38420751
91Arginine and proline metabolism_Homo sapiens_hsa003300.38317921
92Biosynthesis of amino acids_Homo sapiens_hsa012300.37591789
93Renin-angiotensin system_Homo sapiens_hsa046140.37404029
94Hematopoietic cell lineage_Homo sapiens_hsa046400.37221096
95Galactose metabolism_Homo sapiens_hsa000520.36531138
96Vitamin B6 metabolism_Homo sapiens_hsa007500.36452395
97Vibrio cholerae infection_Homo sapiens_hsa051100.36369776
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35870727
99Protein digestion and absorption_Homo sapiens_hsa049740.35677536
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.35361875
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35067266
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34971865
103Glucagon signaling pathway_Homo sapiens_hsa049220.34585202
104Influenza A_Homo sapiens_hsa051640.33997062
105ECM-receptor interaction_Homo sapiens_hsa045120.32346954
106Insulin signaling pathway_Homo sapiens_hsa049100.32229056
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31782435
108Tuberculosis_Homo sapiens_hsa051520.31214751
109Prolactin signaling pathway_Homo sapiens_hsa049170.30803024
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30227670
111Toxoplasmosis_Homo sapiens_hsa051450.28627598
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28593318
113Chemokine signaling pathway_Homo sapiens_hsa040620.28423092
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.27230157
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26249021
116Folate biosynthesis_Homo sapiens_hsa007900.26209253
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.25810710
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25166727
119FoxO signaling pathway_Homo sapiens_hsa040680.25022443
120Focal adhesion_Homo sapiens_hsa045100.22555550
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22106062
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.22007174
123African trypanosomiasis_Homo sapiens_hsa051430.20923151
124Legionellosis_Homo sapiens_hsa051340.19537031
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18675779
126Phagosome_Homo sapiens_hsa041450.18663977
127B cell receptor signaling pathway_Homo sapiens_hsa046620.18623616
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18283083
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17646146
130Hepatitis C_Homo sapiens_hsa051600.17471435
131Ovarian steroidogenesis_Homo sapiens_hsa049130.17277899
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16571407
133Sulfur relay system_Homo sapiens_hsa041220.16526608
134Proteoglycans in cancer_Homo sapiens_hsa052050.16388598
135Adherens junction_Homo sapiens_hsa045200.15585371

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